Anti-Apoptotic

Name	AC	CK
Ginsenosides	77	139
Curcumin	52	82
Tanshinone IIA	38	82
Astragaloside	35	70
Astaxanthin	42	64
Melatonin	36	61
Puerarin	36	60
Flavonoids	33	58
Vitamin C	24	54
Berberine	29	53
Resveratrol	33	53
Thymoquinone	28	49
Paeoniflorin	29	40
Quercetin	19	39
Apigenin	17	36
Citrus naringin	20	33
EGCG (Epigallocatechin gallate)	21	33
Grape Seed Extract	19	33
Gastrodin	17	31
Alpha-Lipoic Acid	14	27
Chrysin	16	27
Lycopene	16	26
Safflower	18	26
Selenium	13	26
Crocin	16	25
Ginkgo biloba	13	25
Kaempferol	11	24
Polyphenols	12	24
Ligustrazine	13	23
Hesperidin	11	22
Anthocyanins	14	21
Paeonol	13	21
Nobiletin	12	20
Asiatic Acid	12	19
Pomegranate	9	19
Genistein	10	18
Mangiferin	10	18
Royal Jelly	5	18
Catechin	7	17
Emodin	11	17
Fucoidan	12	17
Huperzine	10	17
Coenzyme Q10	10	16
Honokiol	10	16
Hydrogen Water	9	16
Moringa oleifera	9	16
Cannabidiol	10	15
NAC (N-acetyl-L-cysteine)	7	15
Myricetin	10	14
Nigella sativa (aka Black Seed)	8	14
Reishi Mushroom	8	14
Rutin	9	14
Sulforaphane	6	14
Vitamin E	8	14
Betulinic acid	7	13
Carnosic Acid	7	13
Chlorogenic Acid	8	13
Garlic	8	13
Pterostilbene	8	13
Punicalagin	6	13
Rose	9	13
Bergamot orange	2	12
Cordyceps sinensis	7	12
Ferulic acid	8	12
Fisetin	7	12
Ginger	6	12
Goji	9	12
Naringenin	8	12
Oleuropein	8	12
Probiotics	6	12
Sea buckthorn	2	12
Vitexins	9	12
Allicin	7	11
Baicalein	7	11
Ellagic Acid	7	11
Honeysuckle	8	11
Lotus	10	11
Persimmon	7	11
Turmeric	5	11
Vitamin D	5	11
Angelica	5	10
Blueberry	6	10
Caffeic acid phenethyl ester	6	10
Camel Milk	1	10
Eriodictyol	6	10
Fucoxanthin	5	10
Oleanolic acid	5	10
Saffron	6	10
Carvacrol	5	9
Dates	5	9
Dogwood	6	9
Gingerol	4	9
Hydroxytyrosol	5	9
Luteolin	7	9
Medicinal Mushrooms	5	9
Panax Notoginseng	6	9
Peony	7	9
Urolithin A	6	9
Bee Venom	5	8
Bilberry	5	8
Formononetin	5	8
Green Tea	5	8
P-Coumaric Acid	5	8
Piperine	5	8
Shikonin	4	8
Spirulina	4	8
Strawberry	4	8
Walnut	5	8
Apple	4	7
Astragalus	2	7
Beet	4	7
Biochanin A	4	7
Burdock	4	7
Carnosine	4	7
Curcuminoids	2	7
Delphinidin	3	7
Delta-tetrahydrocannabinol (THC)	3	7
Garlic: Aged	4	7
Geraniol	4	7
Gotu Kola	5	7
Isoliquiritigenin	5	7
Olive leaf extract	4	7
Rooibos	4	7
Rosemaric Acid	4	7
Ursolic Acid	4	7
Verbascoside	3	7
Water: Deep Sea	4	7
Ashwagandha	4	6
Celastrol	4	6
Chaga Mushroom (Inonotus obliquus)	3	6
Cordyceps Militaris	3	6
Cyanidin 3-glucoside	4	6
Diosgenin	3	6
Diosmin	3	6
Fermented Foods and Beverages	3	6
Licorice	4	6
Lion's Mane (Hericium Erinaceus)	5	6
Lychee	3	6
Magnolol	4	6
Neem	3	6
Nettle	3	6
Palmitoylethanolamide	3	6
Prickly Pear Cactus	3	6
Proanthocyanidins	4	6
Safranal	4	6
Sesamin	3	6
Sesamol	3	6
Zinc	4	6
Bee Propolis	3	5
Cocoa	3	5
Diosmetin	3	5
Eugenol	3	5
Fenugreek	3	5
Folic Acid	5	5
Ginseng (Korean)	4	5
Indole-3-Carbinol	4	5
Mangosteen	3	5
Okra	3	5
Onion	3	5
Theanine	3	5
Vanillin	3	5
Vitamin E: alpha tocopherol	4	5
White Mulberry	3	5
Agaricus Blazei	2	4
Aloe Vera	2	4
Apple Polyphenols	2	4
Arctigenin	2	4
Artesunate	2	4
Babchi	2	4
Bee Pollen	2	4
Bitter Melon	2	4
Black Pepper	2	4
Crocetin	2	4
Dandelion	3	4
Diallyl sulfide	2	4
Gynostemma	3	4
Lactobacillus paracasei	2	4
Olive	2	4
Oregano	2	4
Parthenolide	4	4
Phellinus Linteus	4	4
Piceatannol	4	4
Procyanidin B2	3	4
Propolis: Bee	2	4
Pycnogenol (Pine Bark)	2	4
Red Sage	2	4
Tannic Acid	2	4
Taurine	3	4
Tetrahydrocurcumin	3	4
Xanthohumol	2	4
Zerumbone	3	4
Amla Fruit	2	3
Bacopa	3	3
Bamboo	2	3
Barberry	2	3
Betaine	2	3
Bitter Orange	2	3
Butterbur	2	3
Capsaicin	2	3
Cardamonin	2	3
Chrysanthemum Indicum	2	3
Cryptoxanthin	2	3
Cyanidin	2	3
Frankincense	3	3
Ginseng	2	3
Guduchi	2	3
Hydrangea	2	3
Isoflavones	2	3
Kombucha Tea	2	3
Lactobacillus plantarum	2	3
Lactoferrin	3	3
Lemon Balm	2	3
Lentinan	2	3
Mugwort	2	3
Mulberry	2	3
Noni	2	3
Nordihydroguaiaretic acid (NDGA)	2	3
Oridonin	2	3
Poria cocos	2	3
Rosmarinic acid	2	3
Seaweed	2	3
Tangeretin	2	3
Theaflavins	2	3
Toona sinensis	2	3
Wogonin	2	3
acetyl-11-keto-beta-boswellic acid	2	3
6-Shogaol	2	2
Acacia catechu	1	2
Achiote	1	2
Agaricus brasiliensis	1	2
Antrodia camphorata	2	2
Apocynin	1	2
Apple Cider Vinegar	1	2
Apples	1	2
Apricot	1	2
Banaba	1	2
Banana	1	2
Barley	1	2
Basil	1	2
Berbamine	1	2
Bergamot	1	2
Beta Sitosterol	1	2
Beta-Caryophyllene	2	2
Bifidobacterium Longum	1	2
Black Currant	1	2
Black Raspberry	1	2
Bloodroot	1	2
Buckwheat	1	2
Carnosol	1	2
Carotenoids	2	2
Celery	1	2
Chamomile	1	2
Chlorella (Algae)	1	2
Chocolate	1	2
Cinnamon	1	2
Citrus Peel	1	2
Coconut Oil	1	2
Coriandrum sativum	1	2
Corn Silk	2	2
Coumestrol	1	2
Curry Tree	1	2
Cysteine (see N-Acetylcysteine)	1	2
DHA (Docosahexaenoic Acid)	1	2
Dong Quai	1	2
Eucalyptus	1	2
Evening Primrose Oil	1	2
False Black Pepper	1	2
Fig	1	2
Gardenia	1	2
Ginseng (American)	1	2
Glycyrrhiza uralensis	2	2
Graviola	1	2
Guava	1	2
Hibiscus sabdariffa	1	2
Honey	1	2
Hops	1	2
Hu Zhang (Polygonum cuspidatum)	1	2
Huaier (Trametes robiniophila murr)	1	2
Isoquercitrin	2	2
Japanese cypress	1	2
Kimchi	1	2
L-arginine	1	2
Lactobacillus helveticus	1	2
Lactobacillus reuteri	1	2
Lactobacillus rhamnosus GG	1	2
Lemon Verbena	1	2
Lingonberry	2	2
Long Pepper	1	2
Loquat	1	2
Milk Thistle	1	2
Nutmeg	1	2
Oligonol	1	2
Oligosaccharides	1	2
Omega-3 Fatty Acids	1	2
Orange	1	2
Panax Ginseng	1	2
Parsley	1	2
Perilla	1	2
Phloretin	2	2
Piperlongumine	1	2
Psychedelics:All	1	2
Psyllium	1	2
Raspberry ketone	1	2
Red Cabbage	1	2
Rhubarb	1	2
Rosemary	1	2
Salvia divinorum	1	2
Saw Palmetto	1	2
Shilajit	1	2
Silymarin	1	2
Spinach	1	2
St. Johns Wort	1	2
Star Fruit	1	2
Stilbenes	2	2
Sweet Potato	1	2
Sweet Potato: Purple	1	2
Syrian rue	1	2
Tauroursodeoxycholic acid	2	2
Terminalia	1	2
Thistle	2	2
Turkey Tail Mushroom	1	2
Ubiquinol	1	2
Vinegar	1	2
Vitamin B-3 (Niacin)	1	2
Water: Deuterium Depleted	1	2
Yellow Sweet Clover (Melilotus officinalis)	1	2
Yoghurt	1	2
neohesperidin	1	2
Adlay	1	1
Anandamide	1	1
Avenanthramides	1	1
Avocado	1	1
Ayurvedic formulation: Liv52	1	1
Bay Laurel	1	1
Beta-Elemene	1	1
Betanin	1	1
Betel	1	1
Bisdemethoxycurcumin	1	1
Black Tea Theaflavins	1	1
Caffeic Acid	1	1
Cannabinoids	1	1
Cannabis	1	1
Celery seed	1	1
Chokeberry	1	1
Cucurbitacin E	1	1
Daidzein	1	1
Dihydrocurcumin	1	1
Echinacea	1	1
Endocannabinoids	1	1
Galactooligosaccharides	1	1
Genipin	1	1
Glycyrrhizin	1	1
Grape	1	1
Grapefruit peel extract	1	1
Hawthorn	1	1
Hibiscus	1	1
Jujube	1	1
Kefir	1	1
Kiwifruit	1	1
Lignans	1	1
Lime	1	1
Liquiritigenin	1	1
Lupeol	1	1
Lutein	1	1
Magnolia	1	1
Maple	1	1
Oat Bran	1	1
Oats	1	1
Oleocanthal	1	1
Organosulfur Compounds	1	1
Orthosiphon	1	1
Patchouli	1	1
Phyllanthus emblica	1	1
Policosanol	1	1
Prunella vulgaris	1	1
Purslane	1	1
Raspberry	1	1
Red Clover	1	1
Salvia miltiorrhiza	1	1
Schisandra	1	1
Seaweed: Brown	1	1
Silibinin	1	1
Sweet Orange	1	1
Terminalia chebula	1	1
Tomatidine	1	1
Vitamin K2	1	1
Yerba Mate	1	1
Zataria multiflora	1	1
beta-Carotene	1	1

[+]

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Pubmed Data : Med Acupunct. 2019 Oct 1 ;31(5):289-297. Epub 2019 Oct 17. PMID: 31624528

Article Published Date : Sep 30, 2019

Study Type : Human Study

Additional Links

Diseases : Infertility: Female

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Anti-Apoptotic, Fertility Agents: Female

[+]

Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults.Jan 21, 2020

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Pubmed Data : J Pharm Pharmacol. 2017 Mar ;69(3):334-340. Epub 2017 Feb 3. PMID: 28155996

Article Published Date : Feb 28, 2017

Study Type : Human In Vitro

Additional Links

Substances : Curcuminoids, Turmeric

Diseases : Macular Degeneration, Photooxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Photoprotective

[+]

Ginger efficiently reduced the lung damage and protected the lungs from severe damage due to hyperoxia and inflammation. Aug 15, 2018

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Pubmed Data : Turk J Med Sci. 2018 Aug 16 ;48(4):892-900. Epub 2018 Aug 16. PMID: 30121057

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Pubmed Data : Synapse. 2020 Jul 8:e22181. Epub 2020 Jul 8. PMID: 32639628

Article Published Date : Jul 07, 2020

Study Type : Animal Study

Additional Links

Substances : Genistein

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

[+]

Neuroprotective effect of chrysin on isoniazid-induced neurotoxicity via suppression of oxidative stress, inflammation and apoptosis in rats Nov 30, 2020

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Pubmed Data : Neurotoxicology. 2020 Dec ;81:197-208. Epub 2020 Oct 26. PMID: 33121995

[+]

A mixture of curcumin, hesperidin and rutin ameliorates hepatic oxidative stress caused by STZ-induced hyperglycemia.Aug 11, 2015

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Pubmed Data : Curr Neurovasc Res. 2015 Aug 12. Epub 2015 Aug 12. PMID: 26265154

Article Published Date : Aug 11, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin, Hesperidin, Rutin

Diseases : Diabetes Mellitus: Type 2, Hyperglycemia, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective, Hypoglycemic Agents, Hypolipidemic, Superoxide Dismutase Up-regulation

[+]

A standardized extract of neem has neuroprotective effects in partial sciatic nerve injury.Dec 31, 2016

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Administration of Nigella sativa can be used to prevent formaldehyde induced apoptosis and epithelial damage.Apr 30, 2017

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Pubmed Data : Niger J Clin Pract. 2017 May ;20(5):523-529. PMID: 28513508

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Pubmed Data : Biol Trace Elem Res. 2017 Nov ;180(1):153-163. Epub 2017 Mar 10. PMID: 28283953

Article Published Date : Oct 31, 2017

Study Type : Animal Study

Additional Links

Substances : Agaricus Blazei

Diseases : Cadmium Poisoning

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants

Problem Substances : Cadmium

[+]

AGE has an ameliorative effect against CP-induced oxidative stress and renal damage through its antioxidant, anti-inflammatory and antiapoptotic properties. Dec 31, 2013

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Pubmed Data : Cancer Cell Int. 2014 ;14(1):92. Epub 2014 Sep 28. PMID: 25298749

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Garlic: Aged

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Renoprotective

Additional Keywords : Plant Extracts

[+]

Aged garlic extract attenuates neuronal injury in a rat model of spinal cord ischemia/reperfusion injury.May 31, 2016

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Pubmed Data : J Med Food. 2016 Jun ;19(6):601-6. Epub 2016 May 16. PMID: 27183321

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Pubmed Data : Andrologia. 2020 Jan 8:e13504. Epub 2020 Jan 8. PMID: 31912924

Article Published Date : Jan 07, 2020

Study Type : Animal Study

Additional Links

Substances : Curry Tree

Diseases : Bisphenol Toxicity, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Problem Substances : Bisphenol A

[+]

Alleviation of lead acetate-induced nephrotoxicity by Moringa oleifera extract.Jun 11, 2020

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Pubmed Data : Environ Sci Pollut Res Int. 2020 Jun 12. Epub 2020 Jun 12. PMID: 32529628

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Pubmed Data : Andrologia. 2021 Apr ;53(3):e13990. Epub 2021 Feb 2. PMID: 33529370

Article Published Date : Mar 31, 2021

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents

[+]

Alpha lipoic acid possess protective effects against chlorpyrifos induced liver injury.Feb 22, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 Jul 11. Epub 2018 Jul 11. PMID: 30017190

Article Published Date : Jul 10, 2018

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Apoptotic

[+]

Alpha-lipoic acid treatment prior to radiation decreases the severity and duration of radiation-induced enteritis.Mar 02, 2016

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Pubmed Data : Int J Reprod Biomed (Yazd). 2019 Dec ;17(11):807-818. Epub 2019 Dec 26. PMID: 31911963

Article Published Date : Nov 30, 2019

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Pesticide Toxicity , Testicular Injury: Chemical/Metal Induced

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Malondialdehyde Down-regulation

Problem Substances : Paraquat

[+]

AMPK contributes to cardioprotective effects of pterostilbene against myocardial ischemia-reperfusion injury.Dec 31, 2017

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Pubmed Data : Toxicol Mech Methods. 2017 Jan 22:1-27. Epub 2017 Jan 22. PMID: 28110594

Article Published Date : Jan 21, 2017

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Pubmed Data : Placenta. 2018 Jun ;66:1-7. Epub 2018 Apr 16. PMID: 29884297

Article Published Date : May 31, 2018

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Hypoxia, Pregnancy Complications

Pharmacological Actions : Anti-Apoptotic, Antioxidants

[+]

Anthocyanin rich extract of red cabbage alleviates experimentally induced myocardial infarction.Dec 31, 2016

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Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:7973098. Epub 2019 Mar 20. PMID: 31015891

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

[+]

Apple extracts can extend cellular lifespan by lowering the level of intracellular ROS and by the activation of cellular signalling pathways.Apr 04, 2017

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Pubmed Data : BMC Complement Altern Med. 2017 Apr 5 ;17(1):200. Epub 2017 Apr 5. PMID: 28381226

Article Published Date : Apr 04, 2017

Study Type : Animal Study

Additional Links

Substances : Apple, Apple Polyphenols

Diseases : Aging, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants

Additional Keywords : Plant Extracts

[+]

Apple intake, specifically boiled apple, might reduce the risk of coronary heart disease by inhibiting postocclusion steps, such as myocardial injury after artery occlusion.Oct 31, 2014

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Pubmed Data : Nutr Res. 2014 Nov ;34(11):951-60. Epub 2014 Aug 27. PMID: 25304826

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Pubmed Data : Front Immunol. 2018 ;9:1881. Epub 2018 Aug 16. PMID: 30177931

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Arctigenin

Diseases : Hepatitis: Lectin-Induced (concanavalin)

Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors, Hepatoprotective

Problem Substances : Concanavalin A

[+]

Arctium lappa could be considered a potentially valuable medicinal food for dry age-related macular degeneration.Apr 08, 2020

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Pubmed Data : PLoS One. 2016;11(6):e0157982. Epub 2016 Jun 23. PMID: 27336157

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Dry Eye Syndromes

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

[+]

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Pubmed Data : Food Funct. 2016 Apr ;7(4):1999-2005. PMID: 26999333

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Asiatic Acid

Diseases : Parkinson's Disease

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Asiatic acid may be a potential therapeutic agent for glaucoma.Dec 31, 2017

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Pubmed Data : Mediators Inflamm. 2014 ;2014:954502. Epub 2014 Apr 17. PMID: 24860243

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic

[+]

Astaxanthin improves cognitive deficits from oxidative stress in diabetes rats.Dec 31, 2014

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Pubmed Data : Int Immunopharmacol. 2017 Jan 30 ;45:26-33. Epub 2017 Jan 30. PMID: 28152447

Article Published Date : Jan 29, 2017

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Astaxanthin significantly ameliorates total body irradiation induced bone marrow suppression by inhibiting apoptosis of hematopoietic cells.Jan 22, 2017

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Pubmed Data : Diabetes Metab Syndr Obes. 2021 ;14:1871-1883. Epub 2021 Apr 28. PMID: 33953586

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

[+]

Astragaloside IV protects ethanol-induced gastric mucosal injury.Dec 31, 2018

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Pubmed Data : Life Sci. 2021 Jun 15 ;275:119414. Epub 2021 Mar 24. PMID: 33774032

Article Published Date : Jun 14, 2021

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors, Cardioprotective

[+]

Astragaloside suppresses apoptosis of the podocytes in rats with diabetic nephropathy.Jul 31, 2018

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Pubmed Data : Life Sci. 2018 Aug 1 ;206:77-83. Epub 2018 May 22. PMID: 29792879

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Pubmed Data : BMC Complement Altern Med. 2016 ;16(1):120. Epub 2016 Apr 23. PMID: 27107819

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Pubmed Data : Acta Pharmacol Sin. 2016 Jan 25. Epub 2016 Jan 25. PMID: 26806299

Article Published Date : Jan 24, 2016

Study Type : Animal Study

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Substances : Berberine

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Cardioprotective

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Berberine attenuates cerebral ischemia-reperfusion injury induced neuronal apoptosis.Dec 31, 2020

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Pubmed Data : Molecules. 2017 Apr 21 ;22(4). Epub 2017 Apr 21. PMID: 28430162

Pubmed Data : Mol Med Rep. 2016 Aug 4. Epub 2016 Aug 4. PMID: 27498600

Article Published Date : Aug 03, 2016

Study Type : Animal Study

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Substances : Caffeic acid phenethyl ester

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents

Problem Substances : Anaesthetic Gases

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Caffeic acid phenethyl ester mitigates cadmium-induced hepatotoxicity.Dec 31, 2020

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Pubmed Data : Ecotoxicol Environ Saf. 2021 Jan 1 ;207:111578. Epub 2020 Nov 3. PMID: 33254423

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Caffeic acid phenethyl ester

Diseases : Chemically-Induced Liver Damage, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective, MicroRNA modulator

Problem Substances : Cadmium

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Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders.Sep 30, 2020

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Pubmed Data : Food Chem Toxicol. 2020 Oct ;144:111636. Epub 2020 Jul 30. PMID: 32739455

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Chlorella vulgaris or Spirulina platensis mitigate lead acetate-induced testicular oxidative stress and apoptosis.Mar 21, 2021

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Pubmed Data : Environ Sci Pollut Res Int. 2021 Mar 22. Epub 2021 Mar 22. PMID: 33754266

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Pubmed Data : Mol Biol Rep. 2020 Feb ;47(2):1161-1171. Epub 2019 Dec 9. PMID: 31820315

Article Published Date : Jan 31, 2020

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Apoptotic, Hepatoprotective

Problem Substances : Arsenic

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Chlorogenic acid supplementation may be favourable to avoid aluminium induced hematotoxicity and hepatotoxicity for humans.Jul 31, 2017

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Pubmed Data : Chem Biol Interact. 2017 Aug 1 ;273:125-132. Epub 2017 Jun 13. PMID: 28623112

Pubmed Data : J Biochem Mol Toxicol. 2017 Nov ;31(11). Epub 2017 Jul 6. PMID: 28682524

Pubmed Data : CNS Neurol Disord Drug Targets. 2015 ;14(6):791-803. PMID: 25714970

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Anthocyanins, Vitamin C

Diseases : Alcohol Toxicity , DNA damage

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Genoprotective, Neuroprotective Agents

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Pubmed Data : Immunopharmacol Immunotoxicol. 2020 Apr ;42(2):119-127. Epub 2020 Feb 27. PMID: 32105161

Article Published Date : Mar 31, 2020

Study Type : Animal Study

Additional Links

Substances : Cordyceps Militaris

Diseases : Inflammation

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-2 Downregulation

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View the Evidence: 1730 Abstracts with Anti-Apoptotic Research

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Astragaloside IV exerts renal protective effects in animals with diabetes mellitus through multiple signalling pathways.Sep 14, 2020

Available findings demonstrated the preclinical evidence that Ginsenoside-Rb1 has a potential neuroprotective effects.Dec 31, 2019

Tanshinone IIA can effectively improve liver fibrosis and liver function.Dec 31, 2018

28‐days of polyphenol supplementation modulates the acute JNK, BAD, and Bcl‐2 response to heavy resistance exercise.Dec 31, 2017

Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.Aug 31, 2019

Camel milk had a regulatory effect on multiple parameters of inflammatory mediators, immunomodulators, antiapoptosis, and antioxidants.Oct 31, 2015

Cocoa procyanidins attenuate lipid peroxidation associated neuronal cell death in a manner relevant to Alzheimer's disease.May 15, 2009

Effect of vitamin C administration on neutrophil apoptosis in septic patients after abdominal surgery.May 14, 2009

Efficacy of tanshinone IIA and mesenchymal stem cell treatment of learning and memory impairment in a rat model of vascular dementia.Dec 31, 2020

Electroacupuncture can enhance oocyte maturation and fertilization rate, and reduce the granulosa-cell apoptosis index in an IVF program.Sep 30, 2019

Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults.Jan 21, 2020

Moderate-intensity exercise training ameliorates the diabetes-suppressed spermatogenesis and improves sperm parameters.Nov 30, 2019

Royal jelly consumption protects against radiation-induced apoptosis in human peripheral blood leukocytes.Dec 31, 2015

Sea buckthorn leaf extracts protect neuronal PC-12 cells from oxidative stress.Jul 27, 2017

Sudarshan Kriya practice may exert effects on immunity, aging, cell death, and stress regulation through transcriptional regulation.Jan 31, 2008

The in vivo transformation of bergamot juice phenolics in humans, may mitigate stearate-induced inflammation in myeloid angiogenic cells.Dec 05, 2017

Vitamin C inhibits endothelial cell apoptosis in congestive heart failure.Oct 29, 2001

6-Gingerol attenuates ischemia-reperfusion-induced cell apoptosis in human AC16 cardiomyocytes.Dec 31, 2018

Angelica and Astragalus could protect against oxidative stress-induced apoptosis in kidney epithelium.Feb 16, 2016

Apigenin could be a potent dietary anti-oxidant regimen against edifenphos-induced toxicity on human health.Apr 30, 2019

Apigenin reduces proteasome inhibition-induced neuronal apoptosis.Oct 31, 2016

EGCG protected against the effects of Dihydrotestosterone (DHT) by altering the miRNA expression profile in human dermal papilla cells.May 31, 2016

Fucoxanthin reduced the inflammation response and maintained the integrity of the blood-retinal barrier.Nov 24, 2020

Hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis.Jan 14, 2016

Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.Jan 31, 2017

NAC with its protective effects may be a potential compound for prevention of malathion-induced brain injury.Mar 31, 2019

Pomegranate juice attenuated the damaging effects of cigarette smoke on cultured human alveolar cells.Dec 31, 2015

Protective effects of acteoside against X‑ray‑induced damage in human skin fibroblasts.Jul 31, 2015

Protective effects of delphinidin against H2O2-induced oxidative injuries in human retinal pigment epithelial cells.Aug 29, 2019

Punicalagin protects human retinal pigment epithelium cells from ultraviolet radiation-induced oxidative damage.Jun 01, 2020

Resveratrol protects against oxidized low‑density lipoprotein‑induced human umbilical vein endothelial cell apoptosis.Mar 08, 2017

Selenium prevents oxidative stress and apoptosis associated with mobile phone exposure.Aug 01, 2014

Self-assembled betulinic acid can be used to ameliorate the cytotoxic effects of Doxorubicin.Apr 30, 2015

Sulforaphane protects against ethanol-induced apoptosis in neural crest cells, a characteristic of Fetal Alcohol Syndrome, through restoration of Snail1 expression and epithelial-mesenchymal transition.Jul 08, 2019

THC exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.Sep 30, 2012

The present study suggests that Vitamin D3 is a potentially useful agent for limiting influenza A virus-induced cellular injury via its pro-autophagic action.Mar 27, 2020

This demonstrates the broad neuroprotective action of apigenin against AD pathogenesis in a human disease model.Dec 31, 2015

Turmeric extract and its curcuminoids provided significant protection against photooxidative damage and apoptosis retinal cells.Feb 28, 2017

Ginger efficiently reduced the lung damage and protected the lungs from severe damage due to hyperoxia and inflammation. Aug 15, 2018

Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney.Aug 14, 2020

Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.Oct 09, 2019

Genistein attenuates cognitive deficits and neuroapoptosis in hippocampus induced by ketamine exposure.Jul 07, 2020

Neuroprotective effect of chrysin on isoniazid-induced neurotoxicity via suppression of oxidative stress, inflammation and apoptosis in rats Nov 30, 2020

Pycnogenol achieves neuroprotective effects in rats with spinal cord injury by stabilizing the mitochondrial membrane potential.Jun 30, 2020

These findings indicate a novel role for naringin in protecting against fructose-induced cardiac hypertrophy.Jun 20, 2018

"Apoptosis inhibition of capsaicin on myocardial ischemia-reperfusion injury in rats"Feb 28, 2011

2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside protects murine hearts against ischemia/reperfusion injury.Feb 28, 2017

20(R)-Ginsenoside Rg3 protects SH-SY5Y cells against apoptosis induced by oxygen and glucose deprivation/reperfusion.Jan 14, 2017

20(S)-ginsenoside Rg(3) showed the significant protective effects on cyclophosphamide-induced cell DNA damage and apoptosis.Jan 31, 2008

6-gingerol inhibits apoptosis to attenuate myocardial ischemia/reperfusion injury.Dec 31, 2017

6-Gingerol relieves myocardial ischaemia/reperfusion injury.Mar 22, 2021

A combination of chamomile and oregano extracts could form a new class of drugs to treat diabetic complications.Sep 01, 2016

A lipid peroxidation product of DHA regulates mitochondrial homeostasis and reduces apoptosis to reduce reperfusion damage in a rat model of ischemic reperfusion.Jan 01, 2017

A methanolic extract of Piper nigrum ameliorates beta-amyloid (1–42)-induced anxiety and depression by attenuation of the oxidative stress in the rat amygdala.Dec 31, 2014

A mixture of curcumin, hesperidin and rutin ameliorates hepatic oxidative stress caused by STZ-induced hyperglycemia.Aug 11, 2015

A standardized extract of neem has neuroprotective effects in partial sciatic nerve injury.Dec 31, 2016

Acupuncture may improve neurological function, reduce cerebral infarction volume and prolong the time window of thrombolysis.Mar 24, 2020

Administration of bergamot juice potentially may be beneficial for the treatment of inflammatory bowel disease in humans.Nov 26, 2014

Administration of deep sea minerals can be an effective strategy to improve the life expectancy of diabetic subjects.Jun 30, 2016

Administration of medicinal mushrooms under experimental diabetes showed a positive corrective action on the L-arginine/NO system and the ratio between p53 and Bcl-2 proteins.Dec 31, 2014

Administration of N- acetylcysteine and genistein have an additive gastroprotective effect in indomethacin induced gastric injury.Jul 15, 2018

Administration of naringenin to propofol-exposed mice resulted in significant neuroprotective effects.Dec 31, 2019

Administration of Nigella sativa can be used to prevent formaldehyde induced apoptosis and epithelial damage.Apr 30, 2017

Administration of palmitoylethanolamide protects the neurovascular unit and reduces secondary injury after traumatic brain injury.Oct 31, 2012

Administration of parsley oil either as a preventative medicine or as treatment significantly improved cisplatin-induced hepato-cardiotoxicity.Jan 31, 2017

Agaricus blazei Murill polysaccharides inhibited cadmium induced effects on chicken peripheral blood lymphocytes.Oct 31, 2017

AGE has an ameliorative effect against CP-induced oxidative stress and renal damage through its antioxidant, anti-inflammatory and antiapoptotic properties. Dec 31, 2013

Aged garlic extract attenuates neuronal injury in a rat model of spinal cord ischemia/reperfusion injury.May 31, 2016

Ajwa date extract afforded significant protection against carbon tetrachloride-induced hepatocellular injury.Oct 31, 2017

Alleviating chronic kidney disease progression through modulating the critical genus of gut microbiota in a cisplatin-induced Lanyu pig model.Dec 31, 2019

Alleviating impact of hydroethanolic Murraya koenigii leaves extract on bisphenol A instigated testicular lethality and apoptosis.Jan 07, 2020

Alleviation of lead acetate-induced nephrotoxicity by Moringa oleifera extract.Jun 11, 2020

Anti-Apoptotic

View the Evidence:
1730 Abstracts with Anti-Apoptotic Research