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Anti-Apoptotic
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283 Substances Researched for Anti-Apoptotic
Name
AC
CK
Focus
Ginsenosides
55
90
Curcumin
41
63
Puerarin
30
48
Astaxanthin
25
42
Melatonin
24
40
Resveratrol
25
40
Thymoquinone
23
40
Tanshinone IIA
24
35
Berberine
20
32
Flavonoids
15
32
Vitamin C
14
31
Quercetin
11
29
EGCG (Epigallocatechin gallate)
16
27
Citrus naringin
15
25
Astragaloside
17
22
Gastrodin
12
22
Apigenin
9
21
Asiatic Acid
12
19
Ginkgo biloba
10
19
Polyphenols
7
19
Grape Seed Extract
10
18
Anthocyanins
11
17
Hesperidin
8
17
Paeoniflorin
11
17
Royal Jelly
4
16
Cannabidiol
10
15
Huperzine
9
15
Pomegranate
6
15
Catechin
4
14
Ligustrazine
7
14
Alpha-Lipoic Acid
7
13
Genistein
7
13
Kaempferol
3
13
Bergamot orange
2
12
Nigella sativa (aka Black Seed)
7
12
Pterostilbene
7
12
Sea buckthorn
2
12
Crocin
7
11
Baicalein
6
10
Camel Milk
1
10
Fucoidan
6
10
Ginger
5
10
Mangiferin
4
10
Vitexins
8
10
Honokiol
5
9
Persimmon
6
9
Reishi Mushroom
5
9
Rutin
5
9
Selenium
5
9
Betulinic acid
3
8
Bilberry
5
8
Chlorogenic Acid
5
8
Coenzyme Q10
5
8
Fisetin
5
8
Hydrogen Water
5
8
Naringenin
5
8
Nobiletin
5
8
Probiotics
4
8
Shikonin
4
8
Turmeric
3
8
Vitamin E
5
8
Walnut
5
8
Astragalus
2
7
Blueberry
4
7
Delta-tetrahydrocannabinol (THC)
3
7
Ferulic acid
4
7
Geraniol
4
7
Gingerol
2
7
Lycopene
4
7
Oleuropein
5
7
Olive leaf extract
4
7
Rooibos
4
7
Sulforaphane
4
7
Verbascoside
3
7
Water: Deep Sea
4
7
Allicin
4
6
Chrysin
3
6
Goji
4
6
Lychee
3
6
Neem
3
6
Nettle
3
6
Palmitoylethanolamide
3
6
Punicalagin
4
6
Rose
5
6
Saffron
3
6
Strawberry
3
6
Angelica
1
5
Cordyceps sinensis
3
5
Curcuminoids
1
5
Ellagic Acid
3
5
Garlic: Aged
3
5
Green Tea
3
5
Indole-3-Carbinol
4
5
Myricetin
4
5
Panax Notoginseng
3
5
Safranal
3
5
Vanillin
3
5
Vitamin D
3
5
Vitamin E: alpha tocopherol
4
5
Apple
2
4
Apple Polyphenols
2
4
Arctigenin
2
4
Bitter Melon
2
4
Carvacrol
2
4
Diallyl sulfide
2
4
Diosgenin
2
4
Diosmin
2
4
Fermented Foods and Beverages
2
4
Gotu Kola
3
4
Gynostemma
3
4
Isoliquiritigenin
3
4
Lotus
4
4
Luteolin
4
4
Magnolol
2
4
Oleanolic acid
2
4
Olive
2
4
Piperine
3
4
Prickly Pear Cactus
2
4
Rosemaric Acid
2
4
Sesamin
2
4
Sesamol
2
4
Spirulina
2
4
Tannic Acid
2
4
Tetrahydrocurcumin
3
4
White Mulberry
2
4
Zinc
2
4
Ashwagandha
2
3
Bamboo
2
3
Carnosic Acid
2
3
Chrysanthemum Indicum
2
3
Cocoa
2
3
Cryptoxanthin
2
3
Eugenol
2
3
Guduchi
2
3
Hydroxytyrosol
2
3
Kombucha Tea
2
3
Lion's Mane (Hericium Erinaceus)
3
3
NAC (N-acetyl-L-cysteine)
2
3
Onion
2
3
P-Coumaric Acid
2
3
Parthenolide
3
3
Piceatannol
3
3
Tangeretin
2
3
Taurine
2
3
Theaflavins
2
3
Achiote
1
2
Agaricus Blazei
1
2
Agaricus brasiliensis
1
2
Antrodia camphorata
2
2
Apocynin
1
2
Apples
1
2
Apricot
1
2
Bacopa
2
2
Banaba
1
2
Bee Pollen
1
2
Bee Propolis
1
2
Bee Venom
1
2
Berbamine
1
2
Bergamot
1
2
Bifidobacterium Longum
1
2
Black Pepper
1
2
Black Raspberry
1
2
Bloodroot
1
2
Caffeic acid phenethyl ester
1
2
Capsaicin
1
2
Chaga Mushroom (Inonotus obliquus)
1
2
Chamomile
1
2
Chocolate
1
2
Citrus Peel
1
2
Coconut Oil
1
2
Cordyceps Militaris
1
2
Coriandrum sativum
1
2
Coumestrol
1
2
Cysteine (see N-Acetylcysteine)
1
2
Dates
1
2
Folic Acid
2
2
Gardenia
1
2
Garlic
1
2
Ginseng
1
2
Ginseng (American)
1
2
Ginseng (Korean)
2
2
Guava
1
2
Honey
1
2
Hops
1
2
Hu Zhang (Polygonum cuspidatum)
1
2
Isoquercitrin
2
2
Japanese cypress
1
2
Kimchi
1
2
Lactobacillus helveticus
1
2
Lactobacillus paracasei
1
2
Lactobacillus reuteri
1
2
Lactobacillus rhamnosus GG
1
2
Lemon Verbena
1
2
Medicinal Mushrooms
1
2
Milk Thistle
1
2
Noni
1
2
Nordihydroguaiaretic acid (NDGA)
1
2
Nutmeg
1
2
Orange
1
2
Oregano
1
2
Panax Ginseng
1
2
Parsley
1
2
Perilla
1
2
Phloretin
2
2
Propolis: Bee
1
2
Psychedelics:All
1
2
Pycnogenol (Pine Bark)
1
2
Red Cabbage
1
2
Red Sage
1
2
Rhubarb
1
2
Rosemary
1
2
Salvia divinorum
1
2
Seaweed
1
2
Shilajit
1
2
Silymarin
1
2
Spinach
1
2
St. Johns Wort
1
2
Stilbenes
2
2
Sweet Potato: Purple
1
2
Syrian rue
1
2
Tauroursodeoxycholic acid
2
2
Terminalia
1
2
Thistle
2
2
Toona sinensis
1
2
Ursolic Acid
1
2
Vitamin B-3 (Niacin)
1
2
Water: Deuterium Depleted
1
2
Xanthohumol
1
2
Yellow Sweet Clover (Melilotus officinalis)
1
2
Yoghurt
1
2
neohesperidin
1
2
6-Shogaol
1
1
Adlay
1
1
Amla Fruit
1
1
Anandamide
1
1
Avenanthramides
1
1
Ayurvedic formulation: Liv52
1
1
Beet
1
1
Beta-Caryophyllene
1
1
Beta-Elemene
1
1
Betaine
1
1
Bitter Orange
1
1
Black Tea Theaflavins
1
1
Burdock
1
1
Cannabinoids
1
1
Cannabis
1
1
Celery seed
1
1
Chokeberry
1
1
Corn Silk
1
1
Cucurbitacin E
1
1
Delphinidin
1
1
Dihydrocurcumin
1
1
Emodin
1
1
Endocannabinoids
1
1
Fenugreek
1
1
Frankincense
1
1
Fucoxanthin
1
1
Genipin
1
1
Glycyrrhiza uralensis
1
1
Grapefruit peel extract
1
1
Jujube
1
1
Kefir
1
1
Kiwifruit
1
1
Lemon Balm
1
1
Lignans
1
1
Lingonberry
1
1
Lupeol
1
1
Mangosteen
1
1
Maple
1
1
Mulberry
1
1
Oats
1
1
Phellinus Linteus
1
1
Phyllanthus emblica
1
1
Poria cocos
1
1
Proanthocyanidins
1
1
Rosmarinic acid
1
1
Salvia miltiorrhiza
1
1
Schisandra
1
1
Tomatidine
1
1
Urolithin A
1
1
Yerba Mate
1
1
Zerumbone
1
1
acetyl-11-keto-beta-boswellic acid
1
1
Research Articles
932
Cumulative Knowledge Score
1507
Overall Research Rating
EXCELLENT
View the Evidence:
1443 Abstracts with Anti-Apoptotic Research
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[+]
Available findings demonstrated the preclinical evidence that Ginsenoside-Rb1 has a potential neuroprotective effects.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2020 ;11:285. Epub 2020 Mar 31. PMID:
32296332
Article Published Date
: Dec 31, 2019
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Ginsenosides
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Neurogenesis
,
Neuroprotective Agents
[+]
Tanshinone IIA can effectively improve liver fibrosis and liver function.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2019 ;2019:7514046. Epub 2019 Dec 13. PMID:
31915451
Article Published Date
: Dec 31, 2018
Study Type
: Meta Analysis
Additional Links
Substances
:
Tanshinone IIA
Diseases
:
Liver Fibrosis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Fibrotic
,
Anti-Inflammatory Agents
,
Hepatoprotective
[+]
28‐days of polyphenol supplementation modulates the acute JNK, BAD, and Bcl‐2 response to heavy resistance exercise.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Physiol Rep. 2018 Jan ;6(2). PMID:
29380956
Article Published Date
: Dec 31, 2017
Study Type
: Human Study
Additional Links
Substances
:
Polyphenols
Diseases
:
Muscle Damage: Exercise-Induced
Therapeutic Actions
:
Exercise: Resistance Training
Pharmacological Actions
:
Anti-Apoptotic
[+]
Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis.
Aug 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Sep ;18(3):2122-2130. Epub 2019 Jul 12. PMID:
31410167
Article Published Date
: Aug 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Berberine
Diseases
:
Bacterial Vaginosis
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Camel milk had a regulatory effect on multiple parameters of inflammatory mediators, immunomodulators, antiapoptosis, and antioxidants.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 Nov-Dec;67(8):1305-13. Epub 2015 Oct 22. PMID:
26492130
Article Published Date
: Oct 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Camel Milk
Diseases
:
Hepatitis C
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Immunomodulatory
,
Interleukin-10 upregulation
Additional Keywords
:
Vitamin D3
[+]
Cocoa procyanidins attenuate lipid peroxidation associated neuronal cell death in a manner relevant to Alzheimer's disease.
May 15, 2009
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2009 May 15;46(10):1319-27. Epub 2009 Feb 25. PMID:
19248828
Article Published Date
: May 15, 2009
Study Type
: Human Study
Additional Links
Substances
:
Catechin
Diseases
:
Alzheimer's Disease
,
Neurodegenerative Diseases
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Additional Keywords
:
Proanthocyanidins
[+]
Effect of vitamin C administration on neutrophil apoptosis in septic patients after abdominal surgery.
May 14, 2009
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2009 May 15 ;153(2):224-30. Epub 2008 May 21. PMID:
18952228
Article Published Date
: May 14, 2009
Study Type
: Human Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Sepsis
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Electroacupuncture can enhance oocyte maturation and fertilization rate, and reduce the granulosa-cell apoptosis index in an IVF program.
Sep 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Acupunct. 2019 Oct 1 ;31(5):289-297. Epub 2019 Oct 17. PMID:
31624528
Article Published Date
: Sep 30, 2019
Study Type
: Human Study
Additional Links
Diseases
:
Infertility: Female
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Anti-Apoptotic
,
Fertility Agents: Female
[+]
Moderate-intensity exercise training ameliorates the diabetes-suppressed spermatogenesis and improves sperm parameters.
Nov 30, 2019
Click here to read the entire abstract
Pubmed Data
: Andrologia. 2019 Dec ;51(11):e13457. Epub 2019 Oct 23. PMID:
31642094
Article Published Date
: Nov 30, 2019
Study Type
: Human Study
Additional Links
Diseases
:
Diabetic Complications
,
Infertility: Male
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Fertility Agents: Male
[+]
Royal jelly consumption protects against radiation-induced apoptosis in human peripheral blood leukocytes.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Med Phys. 2016 Jan-Mar;41(1):52-7. PMID:
27051171
Article Published Date
: Dec 31, 2015
Study Type
: Human Study
Additional Links
Substances
:
Royal Jelly
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Radioprotective
[+]
Sea buckthorn leaf extracts protect neuronal PC-12 cells from oxidative stress.
Jul 27, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Microbiol Biotechnol. 2017 Jul 28 ;27(7):1257-1265. PMID:
28535611
Article Published Date
: Jul 27, 2017
Study Type
: Human Study
Additional Links
Substances
:
Flavonoids
,
Kaempferol
,
Quercetin
,
Sea buckthorn
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
[+]
Sudarshan Kriya practice may exert effects on immunity, aging, cell death, and stress regulation through transcriptional regulation.
Jan 31, 2008
Click here to read the entire abstract
Pubmed Data
: J Psychosom Res. 2008 Feb ;64(2):213-8. PMID:
18222135
Article Published Date
: Jan 31, 2008
Study Type
: Human Study
Additional Links
Diseases
:
Aging
,
DNA damage
,
Oxidative Stress
Therapeutic Actions
:
Yogic Technique: Sudarshan kriya
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Additional Keywords
:
Gene Expression Regulation
[+]
The in vivo transformation of bergamot juice phenolics in humans, may mitigate stearate-induced inflammation in myeloid angiogenic cells.
Dec 05, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2017 Dec 6 ;9(12). Epub 2017 Dec 6. PMID:
29211032
Article Published Date
: Dec 05, 2017
Study Type
: Human Study
Additional Links
Substances
:
Bergamot orange
Diseases
:
Endothelial Damage
,
Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
[+]
Vitamin C inhibits endothelial cell apoptosis in congestive heart failure.
Oct 29, 2001
Click here to read the entire abstract
Pubmed Data
: Circulation. 2001 Oct 30 ;104(18):2182-7. PMID:
11684628
Article Published Date
: Oct 29, 2001
Study Type
: Human Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Endothelial Dysfunction
,
Heart Failure
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Enzyme Inhibitors
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
6-Gingerol attenuates ischemia-reperfusion-induced cell apoptosis in human AC16 cardiomyocytes.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2019 ;2019:8798653. Epub 2019 Feb 11. PMID:
30886640
Article Published Date
: Dec 31, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Gingerol
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Angelica and Astragalus could protect against oxidative stress-induced apoptosis in kidney epithelium.
Feb 16, 2016
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2016 Feb 17 ;179:412-9. Epub 2015 Dec 21. PMID:
26719285
Article Published Date
: Feb 16, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Angelica
,
Astragalus
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
,
Renoprotective
[+]
Apigenin could be a potent dietary anti-oxidant regimen against edifenphos-induced toxicity on human health.
Apr 30, 2019
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2019 May ;127:218-227. Epub 2019 Mar 22. PMID:
30910686
Article Published Date
: Apr 30, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Apigenin
Diseases
:
DNA damage
,
Lipid Peroxidation
,
Oxidative Stress
,
Pesticide-Induced Toxicity: Organophosphates
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Problem Substances
:
Organophosphate Pesticides
[+]
Apigenin reduces proteasome inhibition-induced neuronal apoptosis.
Oct 31, 2016
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2016 Nov ;41(11):2969-2980. Epub 2016 Aug 29. PMID:
27473386
Article Published Date
: Oct 31, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Apigenin
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
[+]
EGCG protected against the effects of Dihydrotestosterone (DHT) by altering the miRNA expression profile in human dermal papilla cells.
May 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ann Dermatol. 2016 Jun ;28(3):327-34. Epub 2016 May 25. PMID:
27274631
Article Published Date
: May 31, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Alopecia
,
Hair Loss
Pharmacological Actions
:
Anti-Apoptotic
,
MicroRNA modulator
[+]
Hesperidin shielded human keratinocytes from UVB radiation-induced damage and apoptosis.
Jan 14, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomol Ther (Seoul). 2016 Jan 15. Epub 2016 Jan 15. PMID:
26797112
Article Published Date
: Jan 14, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Hesperidin
Diseases
:
Oxidative Stress
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Photoprotective
[+]
Mangiferin could ameliorate methylmercury mediated mitochondrial dysfunction in human hepatic cells in vitro.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2017 Feb ;32(2):630-644. Epub 2016 Mar 28. PMID:
28071871
Article Published Date
: Jan 31, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Mangiferin
Diseases
:
Chemically-Induced Liver Damage
,
Mercury Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Methylmercury
Problem Substances
:
Mercury
[+]
NAC with its protective effects may be a potential compound for prevention of malathion-induced brain injury.
Mar 31, 2019
Click here to read the entire abstract
Pubmed Data
: Toxicology. 2019 Apr 1 ;417:1-14. Epub 2019 Feb 12. PMID:
30769050
Article Published Date
: Mar 31, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
NAC (N-acetyl-L-cysteine)
Diseases
:
Pesticide-Induced Toxicity: Organophosphates
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
Problem Substances
:
Organophosphate Pesticides
[+]
Pomegranate juice attenuated the damaging effects of cigarette smoke on cultured human alveolar cells.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Chron Obstruct Pulmon Dis. 2016 ;11:227-37. Epub 2016 Feb 3. PMID:
26893554
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Pomegranate
Diseases
:
Inflammation
,
Lung Injury: Smoke-Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Protective effects of acteoside against X‑ray‑induced damage in human skin fibroblasts.
Jul 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2015 Aug ;12(2):2301-6. Epub 2015 Apr 16. PMID:
25892089
Article Published Date
: Jul 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Verbascoside
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Bcl-2 protein down-regulation
,
Radioprotective
[+]
Protective effects of delphinidin against H2O2-induced oxidative injuries in human retinal pigment epithelial cells.
Aug 29, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biosci Rep. 2019 Aug 30 ;39(8). Epub 2019 Aug 15. PMID:
31345961
Article Published Date
: Aug 29, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Delphinidin
Diseases
:
Hydrogen Peroxide Induced Toxicity
,
Macular Degeneration
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Nrf2 activation
[+]
Punicalagin protects human retinal pigment epithelium cells from ultraviolet radiation-induced oxidative damage.
Jun 01, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2020 Jun 2 ;9(6). Epub 2020 Jun 2. PMID:
32498245
Article Published Date
: Jun 01, 2020
Study Type
: Human In Vitro
Additional Links
Substances
:
Punicalagin
Diseases
:
Eye Damage
,
Photooxidative Stress
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Heme oxygenase-1 up-regulation
,
Nrf2 activation
[+]
Resveratrol protects against oxidized low‑density lipoprotein‑induced human umbilical vein endothelial cell apoptosis.
Mar 08, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2017 Mar 9. Epub 2017 Mar 9. PMID:
28447714
Article Published Date
: Mar 08, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Resveratrol
Diseases
:
Endothelial Damage
,
Lipid Peroxidation
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Selenium prevents oxidative stress and apoptosis associated with mobile phone exposure.
Aug 01, 2014
Click here to read the entire abstract
Pubmed Data
: Biol Trace Elem Res. 2014 Aug ;160(2):285-93. Epub 2014 Jun 27. PMID:
24965080
Article Published Date
: Aug 01, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Selenium
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidant
,
Cytoprotective
Additional Keywords
:
electromagnetic fields
,
electromagnetic frequencies
,
electromagnetic radiation
,
EMF
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
,
Microwave Radiation
,
Mobile Phone Radiation
Problem Substances
:
Cell Phone Exposure
Adverse Pharmacological Actions
:
Apoptotic
,
Cytotoxic
,
Oxidant
[+]
Self-assembled betulinic acid can be used to ameliorate the cytotoxic effects of Doxorubicin.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2015 May ;72:144-57. Epub 2015 Apr 24. PMID:
26054689
Article Published Date
: Apr 30, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Betulinic acid
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Anti-Apoptotic
,
Chemoprotective Agents
[+]
Sulforaphane protects against ethanol-induced apoptosis in neural crest cells, a characteristic of Fetal Alcohol Syndrome, through restoration of Snail1 expression and epithelial-mesenchymal transition.
Jul 08, 2019
Click here to read the entire abstract
Pubmed Data
: Biochim Biophys Acta Mol Basis Dis. 2019 Jul 8 ;1865(10):2586-2594. Epub 2019 Jul 8. PMID:
31295528
Article Published Date
: Jul 08, 2019
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Fetal Alcoholism
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
Additional Keywords
:
Alcohol
,
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Mesenchymal Stem Cells
,
Pregnancy And Fetal Growth
[+]
THC exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.
Sep 30, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neuropathol Appl Neurobiol. 2012 Oct ;38(6):535-47. PMID:
22236282
Article Published Date
: Sep 30, 2012
Study Type
: Human In Vitro
Additional Links
Substances
:
Delta-tetrahydrocannabinol (THC)
Diseases
:
Oxidative Stress
,
Parkinson's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
The present study suggests that Vitamin D3 is a potentially useful agent for limiting influenza A virus-induced cellular injury via its pro-autophagic action.
Mar 27, 2020
Click here to read the entire abstract
Pubmed Data
: Virus Res. 2020 Mar 28 ;282:197936. Epub 2020 Mar 28. PMID:
32234325
Article Published Date
: Mar 27, 2020
Study Type
: Human In Vitro
Additional Links
Substances
:
Vitamin D
Diseases
:
Influenza A
Pharmacological Actions
:
Anti-Apoptotic
[+]
This demonstrates the broad neuroprotective action of apigenin against AD pathogenesis in a human disease model.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 ;6:31450. Epub 2016 Aug 12. PMID:
27514990
Article Published Date
: Dec 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Apigenin
Diseases
:
Alzheimer's Disease
,
Brain Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Turmeric extract and its curcuminoids provided significant protection against photooxidative damage and apoptosis retinal cells.
Feb 28, 2017
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2017 Mar ;69(3):334-340. Epub 2017 Feb 3. PMID:
28155996
Article Published Date
: Feb 28, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Curcuminoids
,
Turmeric
Diseases
:
Macular Degeneration
,
Photooxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Photoprotective
[+]
Ginger efficiently reduced the lung damage and protected the lungs from severe damage due to hyperoxia and inflammation.
Aug 15, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Turk J Med Sci. 2018 Aug 16 ;48(4):892-900. Epub 2018 Aug 16. PMID:
30121057
Article Published Date
: Aug 15, 2018
Study Type
: Human: Case Report
Additional Links
Substances
:
Ginger
Diseases
:
Bronchopulmonary Dysplasia
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney.
Aug 14, 2020
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2020 Aug 15 ;255:117833. Epub 2020 May 22. PMID:
32450167
Article Published Date
: Aug 14, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Oleuropein
Diseases
:
Inflammation
,
Ischemia
,
Kidney Damage
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
[+]
Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.
Oct 09, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Orthop Surg Res. 2019 Oct 10 ;14(1):319. Epub 2019 Oct 10. PMID:
31601256
Article Published Date
: Oct 09, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Emodin
Diseases
:
Fibrosis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Fibrotic
[+]
These findings indicate a novel role for naringin in protecting against fructose-induced cardiac hypertrophy.
Jun 20, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2018 Jun 21 ;8(1):9464. Epub 2018 Jun 21. PMID:
29930336
Article Published Date
: Jun 20, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Citrus naringin
Diseases
:
Cardiac Hypertrophy
,
High Fructose Diet
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
"Apoptosis inhibition of capsaicin on myocardial ischemia-reperfusion injury in rats"
Feb 28, 2011
Click here to read the entire abstract
Pubmed Data
: Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Mar ;42(2):218-21. PMID:
21500557
Article Published Date
: Feb 28, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Capsaicin
Diseases
:
Myocardial Infarction
,
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside protects murine hearts against ischemia/reperfusion injury.
Feb 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Pharmacol Sin. 2017 Mar ;38(3):317-330. Epub 2017 Jan 23. PMID:
28112174
Article Published Date
: Feb 28, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
20(R)-Ginsenoside Rg3 protects SH-SY5Y cells against apoptosis induced by oxygen and glucose deprivation/reperfusion.
Jan 14, 2017
Click here to read the entire abstract
Pubmed Data
: Bioorg Med Chem Lett. 2017 08 15 ;27(16):3867-3871. Epub 2017 Jun 19. PMID:
28709827
Article Published Date
: Jan 14, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
20(S)-ginsenoside Rg(3) showed the significant protective effects on cyclophosphamide-induced cell DNA damage and apoptosis.
Jan 31, 2008
Click here to read the entire abstract
Pubmed Data
: Arch Toxicol. 2008 Feb ;82(2):117-23. Epub 2007 Jun 28. PMID:
17598087
Article Published Date
: Jan 31, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Malondialdehyde Down-regulation
,
Superoxide Dismutase Up-regulation
[+]
6-gingerol inhibits apoptosis to attenuate myocardial ischemia/reperfusion injury.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2018 ;2018:9024034. Epub 2018 Mar 20. PMID:
29743926
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Gingerol
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
A combination of chamomile and oregano extracts could form a new class of drugs to treat diabetic complications.
Sep 01, 2016
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2016 Sep 2:1-9. Epub 2016 Sep 2. PMID:
27875075
Article Published Date
: Sep 01, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Chamomile
,
Oregano
Diseases
:
Diabetic Complications
Pharmacological Actions
:
Alpha-amylase inhibitor
,
Anti-Apoptotic
,
Hypoglycemic Agents
,
Hypolipidemic
Additional Keywords
:
Natural Substance Synergy
,
Plant Extracts
Problem Substances
:
Alloxan
[+]
A lipid peroxidation product of DHA regulates mitochondrial homeostasis and reduces apoptosis to reduce reperfusion damage in a rat model of ischemic reperfusion.
Jan 01, 2017
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2017 01 ;102:229-239. Epub 2016 Dec 5. PMID:
27932075
Article Published Date
: Jan 01, 2017
Study Type
: Animal Study
Additional Links
Substances
:
DHA (Docosahexaenoic Acid)
,
Omega-3 Fatty Acids
Diseases
:
Myocardial Infarction
,
Tachycardia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
Additional Keywords
:
Cardiovascular Activity
,
Lipid Peroxidation
,
Mitochondria
,
Omega-3 Fatty Acid Metabolism
[+]
A methanolic extract of Piper nigrum ameliorates beta-amyloid (1–42)-induced anxiety and depression by attenuation of the oxidative stress in the rat amygdala.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Behav Brain Funct. 2015 ;11:13. Epub 2015 Mar 29. PMID:
25880991
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Black Pepper
Diseases
:
Alzheimer's Disease
,
Anxiety Disorders
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Anxiolytic
,
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
[+]
A mixture of curcumin, hesperidin and rutin ameliorates hepatic oxidative stress caused by STZ-induced hyperglycemia.
Aug 11, 2015
Click here to read the entire abstract
Pubmed Data
: Curr Neurovasc Res. 2015 Aug 12. Epub 2015 Aug 12. PMID:
26265154
Article Published Date
: Aug 11, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Hesperidin
,
Rutin
Diseases
:
Diabetes Mellitus: Type 2
,
Hyperglycemia
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
,
Hypoglycemic Agents
,
Hypolipidemic
,
Superoxide Dismutase Up-regulation
[+]
A standardized extract of neem has neuroprotective effects in partial sciatic nerve injury.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: EXCLI J. 2017 ;16:546-565. Epub 2017 Apr 18. PMID:
28694757
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Neem
Diseases
:
Nerve Injuries
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Acupuncture may improve neurological function, reduce cerebral infarction volume and prolong the time window of thrombolysis.
Mar 24, 2020
Click here to read the entire abstract
Pubmed Data
: Zhen Ci Yan Jiu. 2020 Mar 25 ;45(3):209-14. PMID:
32202712
Article Published Date
: Mar 24, 2020
Study Type
: Animal Study
Additional Links
Diseases
:
Cerebral Ischemia
,
Stroke
Therapeutic Actions
:
Acupuncture
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Administration of bergamot juice potentially may be beneficial for the treatment of inflammatory bowel disease in humans.
Nov 26, 2014
Click here to read the entire abstract
Pubmed Data
: Clin Nutr. 2014 Nov 27. Epub 2014 Nov 27. PMID:
25491246
Article Published Date
: Nov 26, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Bergamot orange
Diseases
:
Inflammatory Bowel Diseases
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
[+]
Administration of deep sea minerals can be an effective strategy to improve the life expectancy of diabetic subjects.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2016 Jul ;31(7):769-81. Epub 2015 Mar 2. PMID:
25727812
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Water: Deep Sea
Diseases
:
Diabetic Complications
,
Heart Failure
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
Additional Keywords
:
Anti-Apoptotic
,
Cardioprotective
,
Diabetic Complications
,
Heart Failure
,
Water: Deep Sea
[+]
Administration of medicinal mushrooms under experimental diabetes showed a positive corrective action on the L-arginine/NO system and the ratio between p53 and Bcl-2 proteins.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Int J Med Mushrooms. 2015 ;17(4):339-50. PMID:
25954960
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Agaricus brasiliensis
,
Medicinal Mushrooms
,
Reishi Mushroom
Diseases
:
Diabetes Mellitus: Type 1
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Nitric Oxide Inhibitor
[+]
Administration of N- acetylcysteine and genistein have an additive gastroprotective effect in indomethacin induced gastric injury.
Jul 15, 2018
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2018 Jul 16. Epub 2018 Jul 16. PMID:
30011378
Article Published Date
: Jul 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cysteine (see N-Acetylcysteine)
,
Genistein
Diseases
:
Drug-Induced Toxicity: Indomethacin
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Gastroprotective
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Administration of Nigella sativa can be used to prevent formaldehyde induced apoptosis and epithelial damage.
Apr 30, 2017
Click here to read the entire abstract
Pubmed Data
: Niger J Clin Pract. 2017 May ;20(5):523-529. PMID:
28513508
Article Published Date
: Apr 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Formaldehyde Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Cytoprotective
Problem Substances
:
Formaldehyde
[+]
Administration of palmitoylethanolamide protects the neurovascular unit and reduces secondary injury after traumatic brain injury.
Oct 31, 2012
Click here to read the entire abstract
Pubmed Data
: Brain Behav Immun. 2012 Nov ;26(8):1310-21. Epub 2012 Aug 3. PMID:
22884901
Article Published Date
: Oct 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Palmitoylethanolamide
Diseases
:
Brain Injury: Traumatic
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Administration of parsley oil either as a preventative medicine or as treatment significantly improved cisplatin-induced hepato-cardiotoxicity.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Feb ;86:482-491. Epub 2016 Dec 23. PMID:
28012928
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Parsley
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
Additional Keywords
:
Plant Oils
[+]
Agaricus blazei Murill polysaccharides inhibited cadmium induced effects on chicken peripheral blood lymphocytes.
Oct 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biol Trace Elem Res. 2017 Nov ;180(1):153-163. Epub 2017 Mar 10. PMID:
28283953
Article Published Date
: Oct 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Agaricus Blazei
Diseases
:
Cadmium Poisoning
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
Problem Substances
:
Cadmium
[+]
AGE has an ameliorative effect against CP-induced oxidative stress and renal damage through its antioxidant, anti-inflammatory and antiapoptotic properties.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Cell Int. 2014 ;14(1):92. Epub 2014 Sep 28. PMID:
25298749
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Garlic: Aged
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
,
Renoprotective
Additional Keywords
:
Plant Extracts
[+]
Aged garlic extract attenuates neuronal injury in a rat model of spinal cord ischemia/reperfusion injury.
May 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2016 Jun ;19(6):601-6. Epub 2016 May 16. PMID:
27183321
Article Published Date
: May 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Garlic: Aged
Diseases
:
Ischemia
,
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Plant Extracts
[+]
Ajwa date extract afforded significant protection against carbon tetrachloride-induced hepatocellular injury.
Oct 31, 2017
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2017 Nov ;30(6):2183-2191. PMID:
29175788
Article Published Date
: Oct 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Dates
Diseases
:
Liver Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
[+]
Alleviating chronic kidney disease progression through modulating the critical genus of gut microbiota in a cisplatin-induced Lanyu pig model.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Food Drug Anal. 2020 Jan ;28(1):103-114. Epub 2019 Oct 17. PMID:
31883598
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus paracasei
,
Lactobacillus plantarum
,
Probiotics
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Chronic Kidney Disease (CKD)
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Chemoprotective Agents
,
Renoprotective
[+]
Alleviating impact of hydroethanolic Murraya koenigii leaves extract on bisphenol A instigated testicular lethality and apoptosis.
Jan 07, 2020
Click here to read the entire abstract
Pubmed Data
: Andrologia. 2020 Jan 8:e13504. Epub 2020 Jan 8. PMID:
31912924
Article Published Date
: Jan 07, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Curry Tree
Diseases
:
Bisphenol Toxicity
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Problem Substances
:
Bisphenol A
[+]
Alleviation of lead acetate-induced nephrotoxicity by Moringa oleifera extract.
Jun 11, 2020
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2020 Jun 12. Epub 2020 Jun 12. PMID:
32529628
Article Published Date
: Jun 11, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Moringa oleifera
Diseases
:
Kidney Damage: Chemically-Induced
,
Lead Poisoning
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Renoprotective
Problem Substances
:
Lead
[+]
Allicin improves cardiac function by protecting against apoptosis in rat model of myocardial infarction.
Jul 31, 2017
Click here to read the entire abstract
Pubmed Data
: Chin J Integr Med. 2017 Aug ;23(8):589-597. Epub 2016 Jul 13. PMID:
27412589
Article Published Date
: Jul 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Allicin
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
Additional Keywords
:
Allicin
,
Anti-Apoptotic
,
Cardioprotective
,
Myocardial Infarction
[+]
Allicin provided cardioprotection for cardiac hypertrophy.
Nov 30, 2018
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2018 Dec 1 ;51:241-254. Epub 2018 Oct 19. PMID:
30466623
Article Published Date
: Nov 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Allicin
Diseases
:
Cardiac Hypertrophy
,
Endothelial Dysfunction
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Aloe-emodin attenuates myocardial infarction and apoptosis via up-regulating miR-133 expression.
Jul 31, 2019
Click here to read the entire abstract
Pubmed Data
: Pharmacol Res. 2019 Aug ;146:104315. Epub 2019 Jun 14. PMID:
31207343
Article Published Date
: Jul 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Emodin
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Cardioprotective
,
MicroRNA modulator
[+]
Alpha lipoic acid possess protective effects against chlorpyrifos induced liver injury.
Feb 22, 2018
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2018 Feb 23 ;59:17-23. Epub 2018 Feb 23. PMID:
29500983
Article Published Date
: Feb 22, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Chemically-Induced Liver Damage
,
Pesticide Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
Problem Substances
:
Chlorpyrifos
,
Pesticides
[+]
Alpha-lipoic acid could provide a potential treatment for atherosclerosis in postmenopausal patients.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2018 ;47(6):2261-2277. Epub 2018 Jul 5. PMID:
29975924
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
NF-kappaB Inhibitor
Additional Keywords
:
Ovariectomy-Induced Changes
[+]
Alpha-lipoic acid may be suggested to be a prospective candidate to ameliorate Methotrexate induced oral mucositis.
Feb 14, 2017
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2017 Feb 15 ;171:51-59. Epub 2017 Jan 3. PMID:
28062278
Article Published Date
: Feb 14, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Drug Toxicity: Methotrexate
,
Oral Mucositis
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Alpha-lipoic acid protects against ERS-mediated apoptosis in a cochlear cell model.
Jul 29, 2020
Click here to read the entire abstract
Pubmed Data
: Arch Biochem Biophys. 2020 Jul 30 ;688:108402. Epub 2020 May 11. PMID:
32418909
Article Published Date
: Jul 29, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Hearing Loss
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Alpha-lipoic acid reduces retinal cell death in diabetic mice.
Jul 10, 2018
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 Jul 11. Epub 2018 Jul 11. PMID:
30017190
Article Published Date
: Jul 10, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Diabetic Retinopathy
Pharmacological Actions
:
Anti-Apoptotic
[+]
Alpha-lipoic acid treatment prior to radiation decreases the severity and duration of radiation-induced enteritis.
Mar 02, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Mar 3. Epub 2016 Mar 3. PMID:
26943777
Article Published Date
: Mar 02, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Radiation Induced Illness: Enteritis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Radioprotective
[+]
Ameliorating effect of Citrus aurantium extracts and nobiletin on β‑amyloid (1‑42)‑induced memory impairment.
Aug 08, 2019
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2019 Aug 9. Epub 2019 Aug 9. PMID:
31432129
Article Published Date
: Aug 08, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Bitter Orange
,
Nobiletin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Amelioration of radiation enteropathy by dietary supplementation with reduced coenzyme Q10.
Mar 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Adv Radiat Oncol. 2019 Apr-Jun;4(2):237-245. Epub 2019 Jan 31. PMID:
31011668
Article Published Date
: Mar 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
Diseases
:
Enteropathy
,
Radiation Induced Illness
Pharmacological Actions
:
Anti-Apoptotic
,
Radioprotective
[+]
Ameliorative effects of crocin on paraquat-induced oxidative stress in testis.
Nov 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Reprod Biomed (Yazd). 2019 Dec ;17(11):807-818. Epub 2019 Dec 26. PMID:
31911963
Article Published Date
: Nov 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Crocin
Diseases
:
Pesticide Toxicity
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Malondialdehyde Down-regulation
Problem Substances
:
Paraquat
[+]
AMPK contributes to cardioprotective effects of pterostilbene against myocardial ischemia-reperfusion injury.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2018 ;46(4):1381-1397. Epub 2018 Apr 18. PMID:
29689567
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Pterostilbene
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Cardioprotective
[+]
An aqueous extract of Saudi red propolis protects against lung damage induced by methicillin resistant S aureus.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Pak J Pharm Sci. 2016 Jul ;29(4):1197-207. PMID:
27393432
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Bee Propolis
Diseases
:
Methicillin-resistant Staphylococcus aureus
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cytoprotective
[+]
An ethyl acetate extract of persimmon leaves has a potent protective effect on cognitive deficits induced by Aβ in rats.
Jun 14, 2016
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2016 Jun 15 ;23(7):694-704. Epub 2016 Apr 11. PMID:
27235708
Article Published Date
: Jun 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Persimmon
Pharmacological Actions
:
Anti-Apoptotic
,
Malondialdehyde Down-regulation
,
Neuroprotective Agents
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Plant Extracts
[+]
An extract of Fragaria ananassa had a protective effect against cadmium chloride toxicity upon the liver.
Jan 21, 2017
Click here to read the entire abstract
Pubmed Data
: Toxicol Mech Methods. 2017 Jan 22:1-27. Epub 2017 Jan 22. PMID:
28110594
Article Published Date
: Jan 21, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Strawberry
Diseases
:
Cadmium Poisoning
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Bcl-2 protein down-regulation
,
Hepatoprotective
Additional Keywords
:
Plant Extracts
Problem Substances
:
Cadmium
[+]
Angelica sinensis exerts angiogenic and anti-apoptotic effects against cerebral ischemia-reperfusion injury.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2017 ;45(8):1683-1708. Epub 2017 Nov 9. PMID:
29121798
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Angelica
Diseases
:
Brain Ischemia
Pharmacological Actions
:
Anti-Angiogenic
,
Anti-Apoptotic
,
Neuroprotective Agents
,
Vascular Endothelial Growth Factor A Inhibitor
[+]
Angelica sinensis polysaccharide protects against acetaminophen-induced acute liver injury
Apr 30, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2018 May ;111:1133-1139. Epub 2018 Feb 19. PMID:
29415408
Article Published Date
: Apr 30, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Chemically-Induced Liver Damage
,
Lipid Peroxidation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
,
Malondialdehyde Down-regulation
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo.
Apr 30, 2012
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2012 May ;56(5):713-24. PMID:
22648618
Article Published Date
: Apr 30, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Achiote
Diseases
:
Retinal Diseases
Pharmacological Actions
:
Anti-Apoptotic
Additional Keywords
:
Plant Extracts
[+]
Antenatal pomegranate juice rescues hypoxia-induced fetal growth restriction in pregnant mice.
May 31, 2018
Click here to read the entire abstract
Pubmed Data
: Placenta. 2018 Jun ;66:1-7. Epub 2018 Apr 16. PMID:
29884297
Article Published Date
: May 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Pomegranate
Diseases
:
Hypoxia
,
Pregnancy Complications
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Anthocyanin rich extract of red cabbage alleviates experimentally induced myocardial infarction.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(8):e0182137. Epub 2017 Aug 1. PMID:
28763488
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Red Cabbage
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Cardioprotective
Additional Keywords
:
Plant Extracts
[+]
Anthocyanins from bilberry extract have strong antioxidant properties and therefore can be considered as powerful hepatoprotectives in natural products.
Jul 14, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Jul 15 ;157:168-77. Epub 2016 Jun 14. PMID:
27312419
Article Published Date
: Jul 14, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Bilberry
Diseases
:
Chemically-Induced Liver Damage
,
Lipid Peroxidation
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Plant Extracts
[+]
Anthocyanins may exhibit protective effects against high glucose induced renal injury in diabetic nephropathy via antioxidant activity.
Feb 28, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Med. 2018 Mar ;41(3):1608-1618. Epub 2018 Jan 10. PMID:
29328429
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Anthocyanins
,
Grape Seed Extract
Diseases
:
Diabetes: Oxidative Stress
,
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Renoprotective
Additional Keywords
:
Proanthocyanidins
[+]
Anti-inflammatory and anti-apoptosis activity of taraxasterol in ulcerative colitis in vitro and in vivo.
Aug 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Sep ;18(3):1745-1751. Epub 2019 Jul 5. PMID:
31410133
Article Published Date
: Aug 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Dandelion
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Anti-inflammatory, antioxidant and anti-apoptotic activity of diosmin in acetic acid-induced ulcerative colitis.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2018 Jan ;37(1):78-86. Epub 2017 Feb 23. PMID:
29187079
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Diosmin
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy.
May 31, 2018
Click here to read the entire abstract
Pubmed Data
: J Mol Cell Cardiol. 2018 Jun ;119:10-18. Epub 2018 Apr 12. PMID:
29654879
Article Published Date
: May 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Bergamot
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Cardioprotective
,
Chemoprotective Agents
[+]
Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload.
Sep 02, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Transl Psychiatry. 2018 Sep 3 ;8(1):176. Epub 2018 Sep 3. PMID:
30177808
Article Published Date
: Sep 02, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Cognitive Decline/Dysfunction
,
Iron Overload
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Antioxidant and anti-apoptotic effects of royal jelly against nicotine-induced testicular injury in mice.
May 31, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2019 Jun ;34(6):708-718. Epub 2019 Mar 21. PMID:
30896085
Article Published Date
: May 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Royal Jelly
Diseases
:
Testicular Injury: Nicotine-Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Antioxidant, antiapoptotic, and antifibrotic effects of the combination of liposomal resveratrol and carvedilol against doxorubicin-induced cardiomyopathy.
Mar 14, 2020
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2020 Mar 15:e22492. Epub 2020 Mar 15. PMID:
32173980
Article Published Date
: Mar 14, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Fibrotic
,
Antioxidants
,
Cardioprotective
,
Chemoprotective Agents
[+]
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Apr 30, 2017
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2017 May ;46:124-132. Epub 2017 Mar 7. PMID:
28282576
Article Published Date
: Apr 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Paeonol
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Liver Failure: Acute
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
,
NF-kappaB Inhibitor
[+]
Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy model.
Jan 31, 2019
Click here to read the entire abstract
Pubmed Data
: Can J Ophthalmol. 2019 Feb ;54(1):65-74. Epub 2018 Apr 11. PMID:
30851776
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Retinopathy: Hyperoxia-induced
Pharmacological Actions
:
Anti-Apoptotic
[+]
Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis.
Jul 03, 2019
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2019 Jul 4:116623. Epub 2019 Jul 4. PMID:
31279781
Article Published Date
: Jul 03, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Chemoprotective Agents
[+]
Apigenin attenuates edifenphos-induced toxicity.
Aug 31, 2019
Click here to read the entire abstract
Pubmed Data
: Pestic Biochem Physiol. 2019 Sep ;159:163-172. Epub 2019 Jun 24. PMID:
31400778
Article Published Date
: Aug 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Oxidative Stress
,
Pesticide-Induced Toxicity: Organophosphates
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
,
Renoprotective
Problem Substances
:
Organophosphate Pesticides
[+]
Apigenin increased the expression of Bcl-2 and reduced Fas/FasL expression in renal ischemia-reperfusion injury.
Nov 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2017 Dec ;14(6):5345-5354. Epub 2017 Oct 2. PMID:
29285062
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Renoprotective
[+]
Apigenin possesses excellent protective effect against 3-MCPD-induced renal injury.
Dec 24, 2018
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2018 Dec 25 ;296:9-17. Epub 2018 Aug 11. PMID:
30107153
Article Published Date
: Dec 24, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Kidney Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Renoprotective
[+]
Apigenin pre-treatment can protect renal function against ischemia/reperfusion injury and prevent renal tubular cells from apoptosis.
Oct 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ren Fail. 2018 Nov ;40(1):498-505. PMID:
30278824
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Apigenin
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Renoprotective
[+]
Apigenin protected the myocardium against simulated ischemia/reperfusion injury.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2019 ;2019:7973098. Epub 2019 Mar 20. PMID:
31015891
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Apple extracts can extend cellular lifespan by lowering the level of intracellular ROS and by the activation of cellular signalling pathways.
Apr 04, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2017 Apr 5 ;17(1):200. Epub 2017 Apr 5. PMID:
28381226
Article Published Date
: Apr 04, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Apple
,
Apple Polyphenols
Diseases
:
Aging
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Additional Keywords
:
Plant Extracts
[+]
Apple intake, specifically boiled apple, might reduce the risk of coronary heart disease by inhibiting postocclusion steps, such as myocardial injury after artery occlusion.
Oct 31, 2014
Click here to read the entire abstract
Pubmed Data
: Nutr Res. 2014 Nov ;34(11):951-60. Epub 2014 Aug 27. PMID:
25304826
Article Published Date
: Oct 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Apple
Diseases
:
Atherosclerosis
,
Cardiovascular Diseases
,
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-atherogenic
,
Cardioprotective
Additional Keywords
:
Plant Extracts
[+]
Apricot supplementation and irradiation given in combination, offer maximum protection against DMBA-induced hepatic carcinogenesis.
Jul 31, 2014
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2014 Aug ;70:128-33. Epub 2014 May 10. PMID:
24819963
Article Published Date
: Jul 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Apricot
Diseases
:
Chemically-Induced Liver Damage
,
Chemotherapy and Radiation Toxicity
,
Liver Cancer
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anticarcinogenic Agents
,
NF-kappaB Inhibitor
[+]
Arctigenin ameliorates renal impairment and inhibits endoplasmic reticulum stress in diabetic db/db mice.
Apr 14, 2019
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2019 Apr 15 ;223:194-201. Epub 2019 Mar 18. PMID:
30898648
Article Published Date
: Apr 14, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Arctigenin
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Hypoglycemic Agents
[+]
Arctigenin might exert great therapeutic potential in immune-mediated liver injury.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
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Click here to read the complete article.
Pubmed Data
: Front Immunol. 2018 ;9:1881. Epub 2018 Aug 16. PMID:
30177931
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Arctigenin
Diseases
:
Hepatitis: Lectin-Induced (concanavalin)
Pharmacological Actions
:
Anti-Apoptotic
,
Autophagy Inhibitors
,
Hepatoprotective
Problem Substances
:
Concanavalin A
[+]
Arctium lappa could be considered a potentially valuable medicinal food for dry age-related macular degeneration.
Apr 08, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Molecules. 2020 Apr 9 ;25(7). Epub 2020 Apr 9. PMID:
32283798
Article Published Date
: Apr 08, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Burdock
Diseases
:
Macular Degeneration
Pharmacological Actions
:
Anti-Apoptotic
[+]
Artesunate ameliorates sepsis-induced acute lung injury.
Jul 22, 2020
Click here to read the entire abstract
Pubmed Data
: Gene. 2020 Jul 23:144969. Epub 2020 Jul 23. PMID:
32712064
Article Published Date
: Jul 22, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Artesunate
Diseases
:
Lung Injury: Acute
,
Sepsis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
[+]
Artesunate may be of value as a therapeutic agent for osteoarthritis.
Sep 30, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2019 Oct ;44(4):1541-1551. Epub 2019 Jul 26. PMID:
31364719
Article Published Date
: Sep 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Artesunate
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
[+]
Artificial tears containing epigallocatechin gallate and hyaluronic acid had a synergistic effect in the treatment of dry eye syndrome.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016;11(6):e0157982. Epub 2016 Jun 23. PMID:
27336157
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Dry Eye Syndromes
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Natural Substance Synergy
[+]
Ascorbic acid protects male rat brain from oral potassium dichromate-induced oxdative DNA damage and apoptotic changes
Feb 25, 2018
Click here to read the entire abstract
Pubmed Data
: Environ Sci Pollut Res Int. 2018 Feb 26. Epub 2018 Feb 26. PMID:
29484617
Article Published Date
: Feb 25, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
DNA damage
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Ascorbic acid reduced the frequency and severity of renal injury in this murine model of contrast induced nephropathy.
Mar 23, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Nephrol. 2017 Mar 24 ;18(1):101. Epub 2017 Mar 24. PMID:
28340561
Article Published Date
: Mar 23, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
Diseases
:
Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Renoprotective
[+]
Ashwagandha may serve as an effective dietary supplement for management of sleep deprivation induced stress and associated functional impairments.
Dec 20, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2016 Dec 21. Epub 2016 Dec 21. PMID:
28004351
Article Published Date
: Dec 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Ashwagandha
Diseases
:
Brain Inflammation
,
Insomnia
,
Sleep Disorders
Pharmacological Actions
:
Anti-Anxiety Agents
,
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis.
Feb 28, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Mar ;15(3):2397-2403. Epub 2017 Dec 22. PMID:
29467846
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Asiatic Acid
Diseases
:
High Fat Diet
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Apoptotic
[+]
Asiatic acid could be able to modulate various pathological features of Alzheimer's disease and could hold promise in its treatment.
Jan 21, 2019
Click here to read the entire abstract
Pubmed Data
: Neurotox Res. 2019 Jan 22. Epub 2019 Jan 22. PMID:
30671870
Article Published Date
: Jan 21, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Asiatic Acid
Diseases
:
Aluminum Toxicity
,
Alzheimer's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
Problem Substances
:
Aluminum Chloride
[+]
Asiatic acid is a potent nutraceutical agent against the progression of Parkinson's disease.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 Apr ;7(4):1999-2005. PMID:
26999333
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Asiatic Acid
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Asiatic acid may be a potential therapeutic agent for glaucoma.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Neurosci. 2018 ;12:489. Epub 2018 Jul 20. PMID:
30079010
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Asiatic Acid
Diseases
:
Glaucoma
Pharmacological Actions
:
Anti-Apoptotic
[+]
Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation.
Oct 31, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Nov ;107:1354-1362. Epub 2018 Aug 30. PMID:
30257350
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Asiatic Acid
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Chemoprotective Agents
[+]
Aspalathin protects the heart against hyperglycemia-induced oxidative damage.
Jan 13, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2017 Jan 14 ;22(1). Epub 2017 Jan 14. PMID:
28098811
Article Published Date
: Jan 13, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Rooibos
Diseases
:
Hyperglycemia
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Nrf2 activation
[+]
Astaxanthin alleviated acute lung injury by inhibiting oxidative/nitrative stress and the inflammatory response in mice.
Sep 10, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Sep 11 ;95:974-982. Epub 2017 Sep 11. PMID:
28915539
Article Published Date
: Sep 10, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Lung Injury: Acute
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
NF-kappaB Inhibitor
[+]
Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats.
Aug 05, 2010
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2010 Aug 5;186(3):306-15. Epub 2010 May 31. PMID:
20513374
Article Published Date
: Aug 05, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Diabetes: Immune Problems
,
Diabetes: Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Antiproliferative
[+]
Astaxanthin attenuates contrast agent-induced acute kidney injury in vitro and in vivo.
Jan 23, 2018
Click here to read the entire abstract
Pubmed Data
: Int Urol Nephrol. 2018 Jan 24. Epub 2018 Jan 24. PMID:
29368247
Article Published Date
: Jan 23, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Kidney Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Renoprotective
[+]
Astaxanthin attenuates hepatic damages and mitochondrial dysfunction in nonalcoholic fatty liver disease.
May 21, 2020
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2020 May 22. Epub 2020 May 22. PMID:
32446270
Article Published Date
: May 21, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
[+]
Astaxanthin can inhibit the lipid peroxidation, reduce the apoptosis, reduce the spinal cord edema.
Apr 30, 2018
Click here to read the entire abstract
Pubmed Data
: Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 May 1 ;32(5):548-553. PMID:
29806341
Article Published Date
: Apr 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Apoptotic
,
Hypolipidemic
,
Neuroprotective Agents
[+]
Astaxanthin enhances the longevity of Saccharomyces cerevisiae by decreasing oxidative stress and apoptosis.
Dec 31, 2018
Click here to read the entire abstract
Pubmed Data
: FEMS Yeast Res. 2019 Jan 1 ;19(1). PMID:
30312390
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Astaxanthin exerted a reobvious neuroprotective effect in pilocarpine-induced status epilepticus rats.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Cell Neurosci. 2019 ;13:123. Epub 2019 Mar 29. PMID:
30983975
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Epilepsy
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
[+]
Astaxanthin had a significant protective effect on liver fibrosis by suppressing multiple pro-fibrogenic factors.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2014 ;2014:954502. Epub 2014 Apr 17. PMID:
24860243
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Liver Fibrosis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Fibrotic
[+]
Astaxanthin improves cognitive deficits from oxidative stress in diabetes rats.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Pathol. 2015 ;8(6):6083-94. Epub 2015 Jun 1. PMID:
26261486
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Diabetes: Oxidative Stress
,
Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Nitric Oxide Inhibitor
[+]
Astaxanthin is able to suppress learning and memory impairment caused by repeated cerebral ischemia.
May 03, 2017
Click here to read the entire abstract
Pubmed Data
: Brain Res Bull. 2017 May 4 ;131:221-228. Epub 2017 May 4. PMID:
28479214
Article Published Date
: May 03, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Astaxanthin provided protection for the liver against acetaminophen hepatotoxicity.
Jan 29, 2017
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2017 Jan 30 ;45:26-33. Epub 2017 Jan 30. PMID:
28152447
Article Published Date
: Jan 29, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Liver Damage: Drug-Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Astaxanthin significantly ameliorates total body irradiation induced bone marrow suppression by inhibiting apoptosis of hematopoietic cells.
Jan 22, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Stem Cell Res Ther. 2017 Jan 23 ;8(1):7. Epub 2017 Jan 23. PMID:
28115023
Article Published Date
: Jan 22, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Chemotherapy and Radiation Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Nrf2 activation
,
Radioprotective
[+]
Astaxanthin supplementation attenuates soleus muscle atrophy.
Apr 26, 2016
Click here to read the entire abstract
Pubmed Data
: J Physiol Sci. 2016 Apr 27. Epub 2016 Apr 27. PMID:
27117878
Article Published Date
: Apr 26, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Muscle Atrophy
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Astragaloside IV alleviates myocardial damage induced by type 2 diabetes via improving energy metabolism.
Oct 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2019 Nov ;20(5):4612-4622. Epub 2019 Oct 1. PMID:
31702040
Article Published Date
: Oct 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Cardiomyopathy
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Astragaloside IV alleviates the brain damage induced by subarachnoid hemorrhage.
Jun 29, 2020
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2020 Jun 30 ;735:135227. Epub 2020 Jun 30. PMID:
32619654
Article Published Date
: Jun 29, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Subarachnoid hemorrhage
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Astragaloside IV attenuated podocyte apoptosis and protected diabetic rats from diabetic nephropathy.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2018 ;12:2785-2793. Epub 2018 Sep 6. PMID:
30233141
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
[+]
Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca2+ homeostasis.
Apr 18, 2020
Click here to read the entire abstract
Pubmed Data
: Cell Biochem Funct. 2020 Apr 19. Epub 2020 Apr 19. PMID:
32306464
Article Published Date
: Apr 18, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Hypoxia
,
Sleep Apnea: Obstructive
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats.
Jul 19, 2018
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2018 Jul 20. Epub 2018 Jul 20. PMID:
30030530
Article Published Date
: Jul 19, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Astragaloside IV attenuates podocyte apoptosis mediated by endoplasmic reticulum stress in diabetic nephropathy.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2016 ;7:500. Epub 2016 Dec 21. PMID:
28066247
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Renoprotective
[+]
Astragaloside IV could protect against anoxia-reoxygenation injury.
Apr 30, 2016
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2016 May ;94(5):542-53. Epub 2015 Dec 16. PMID:
27070866
Article Published Date
: Apr 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Anoxia
,
Lipid Peroxidation
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Astragaloside IV protects ethanol-induced gastric mucosal injury.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2019 ;10:894. Epub 2019 Aug 15. PMID:
31474858
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Alcohol Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Gastroprotective
[+]
Astragaloside IV protects retinal pigment epithelial cells from apoptosis by upregulating miR-128 expression.
Jun 30, 2020
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2020 Jul ;46(1):340-350. Epub 2020 Apr 23. PMID:
32626913
Article Published Date
: Jun 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Diabetic Retinopathy
Pharmacological Actions
:
Anti-Apoptotic
,
MicroRNA modulator
[+]
Astragaloside IV reduces cardiomyocyte apoptosis in a murine model of coxsackievirus B3-induced viral myocarditis.
Jun 25, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Anim. 2019 Jun 26. Epub 2019 Jun 26. PMID:
31243190
Article Published Date
: Jun 25, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Coxsackievirus Infections
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Astragaloside suppresses apoptosis of the podocytes in rats with diabetic nephropathy.
Jul 31, 2018
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2018 Aug 1 ;206:77-83. Epub 2018 May 22. PMID:
29792879
Article Published Date
: Jul 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
MicroRNA modulator
Additional Keywords
:
Risk Reduction
[+]
Astragaloside-IV might alleviate ischemia reperfusion-induced apoptosis.
Oct 18, 2019
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2019 Oct 19:112319. Epub 2019 Oct 19. PMID:
31639488
Article Published Date
: Oct 18, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
BA may be an effective agent for the prevention and treatment of cadmium-induced diseases in humans.
Dec 14, 2018
Click here to read the entire abstract
Pubmed Data
: Toxicol Lett. 2018 Dec 15 ;299:56-66. Epub 2018 Sep 16. PMID:
30232032
Article Published Date
: Dec 14, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Betulinic acid
Diseases
:
Cadmium Poisoning
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
,
Renoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances
:
Cadmium
[+]
Baicalein alleviated myocardial remodelling and improved cardiac function.
Jan 14, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Jan 15 ;145:213-23. Epub 2015 Dec 17. PMID:
26706290
Article Published Date
: Jan 14, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Baicalein
Diseases
:
Heart Failure
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Baicalein attenuates lung injury induced by myocardial ischemia and reperfusion.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2017 ;45(4):791-811. Epub 2017 May 18. PMID:
28521514
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Baicalein
Diseases
:
Lung Injury: Acute
,
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
[+]
Baicalein possesses anti-inflammatory activities by inhibiting α-synuclein aggregation, inflammasome activation and cathepsin B production.
Oct 10, 2016
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2016 Oct 11. Epub 2016 Aug 11. PMID:
27742410
Article Published Date
: Oct 10, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Baicalein
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Bamboo has anti-apoptic and neuroprotective effects and may be useful for ischemic injury.
Apr 21, 2010
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2010 Apr 21;128(3):594-9. Epub 2010 Feb 1. PMID:
20117201
Article Published Date
: Apr 21, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Bamboo
Diseases
:
Brain Damage
,
Brain Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Banaba has cardioprotective effects and may prevent myocardial stress by suppressing apoptosis through up-regulation of myocardial antioxidant levels.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Cardiovasc Toxicol. 2015 Jan ;15(1):10-22. PMID:
24853613
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Banaba
Diseases
:
Myocardial Ischemia
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Cardioprotective
,
Nrf2 activation
Additional Keywords
:
Plant Extracts
[+]
Bee pollen can be used safely to ameliorate oxidative stress, neuroinflammation, poor detoxification, and abnormal gut microbiota.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2016 ;16(1):120. Epub 2016 Apr 23. PMID:
27107819
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Bee Pollen
Diseases
:
Autistic Disorder
,
Brain Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
Additional Keywords
:
Microbiota
[+]
Bee venom improves diabetic wound healing.
Oct 31, 2018
Click here to read the entire abstract
Pubmed Data
: Mol Immunol. 2018 Nov ;103:322-335. Epub 2018 Oct 23. PMID:
30366166
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Bee Venom
Diseases
:
Diabetic Complications
,
Wound Healing
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Nrf2 activation
[+]
Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease.
Sep 30, 2018
Click here to read the entire abstract
Pubmed Data
: Andrologia. 2018 Oct ;50(8):e13065. Epub 2018 Jun 19. PMID:
29923211
Article Published Date
: Sep 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Apple Cider Vinegar
Diseases
:
Infertility: Male
,
Insulin Resistance
,
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Apoptotic
,
Fertility Agents: Male
[+]
Berbamine ameliorates isoproterenol-induced myocardial infarction.
Feb 28, 2019
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2019 Mar ;120(3):3101-3113. Epub 2018 Nov 28. PMID:
30485494
Article Published Date
: Feb 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berbamine
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
Problem Substances
:
Isoproterenol
[+]
Berberine ameliorates myocardial ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis.
Jan 24, 2016
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2016 Jan 25. Epub 2016 Jan 25. PMID:
26806299
Article Published Date
: Jan 24, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats.
Aug 22, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Aug 23 ;95:175-185. Epub 2017 Aug 23. PMID:
28843149
Article Published Date
: Aug 22, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Hypoglycemic Agents
,
NF-kappaB Inhibitor
,
Pancreato Protective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Diabetes Mellitus: Type 1
[+]
Berberine exerts a protective action against carbon tetrachloride induced acute liver injury.
Aug 05, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2019 Aug 6. Epub 2019 Aug 6. PMID:
31432116
Article Published Date
: Aug 05, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
[+]
Berberine inhibits cardiac remodeling of heart failure after myocardial infarction.
Aug 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Sep ;16(3):2499-2505. Epub 2018 Jul 11. PMID:
30186485
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Berberine is a potential drug for the treatment of patients with ischemia-reperfusion injury.
Jan 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Feb ;15(2):1225-1232. Epub 2017 Nov 27. PMID:
29403554
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
NF-kappaB Inhibitor
[+]
Berberine may be a potential therapeutic agent for the treatment of patients with neonatal necrotizing enterocolitis.
Mar 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Apr ;15(4):3530-3536. Epub 2018 Feb 12. PMID:
29545879
Article Published Date
: Mar 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Enterocolitis: Necrotiziing
Pharmacological Actions
:
Anti-Apoptotic
[+]
Berberine might be a preferable and rational therapeutic approach to ameliorate neuronal injury from hypoxia/ischemia.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Transl Res. 2016 ;8(2):1197-207. Epub 2016 Feb 15. PMID:
27158406
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Autophagy Up-regulation
,
Neuroprotective Agents
[+]
Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress.
Apr 12, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Biochem Funct. 2020 Apr 13. Epub 2020 Apr 13. PMID:
32283563
Article Published Date
: Apr 12, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Betulinic acid
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-metastatic
,
Antiproliferative
[+]
Bilberry anthocyanin extract exhibited protective effects against visible light-induced retinal degeneration.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2015 ;20(12):22395-410. Epub 2015 Dec 14. PMID:
26694327
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Bilberry
Diseases
:
Retinal Degeneration: Light-Induced
,
Retinal Diseases
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
[+]
Bioactive compounds of kimchi inhibit apoptosis by attenuating endoplasmic reticulum stress in the brain of amyloid β-injected mice.
May 15, 2018
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2018 May 16 ;66(19):4883-4890. Epub 2018 May 7. PMID:
29706080
Article Published Date
: May 15, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Kimchi
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
[+]
Biochanin A reduces inflammatory injury and neuronal apoptosis following subarachnoid hemorrhage.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Behav Neurol. 2018 ;2018:1960106. Epub 2018 Jun 3. PMID:
29971136
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Biochanin A
Diseases
:
Brain Inflammation
,
Subarachnoid hemorrhage
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
[+]
Black ginseng extract counteracts streptozotocin-induced diabetes.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(1):e0146843. Epub 2016 Jan 11. PMID:
26751692
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng
,
Ginsenosides
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetes Mellitus: Type 2
,
Hyperglycemia
Pharmacological Actions
:
Anti-Apoptotic
,
Hypoglycemic Agents
Additional Keywords
:
Plant Extracts
[+]
Black ginseng has ameliorative effects against acetaminophen induced hepatotoxicity.
Apr 20, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2017 Apr 21 ;22(4). Epub 2017 Apr 21. PMID:
28430162
Article Published Date
: Apr 20, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
,
Panax Ginseng
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Phytotherapy
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Black seed oil exhibited an anti-aging effect in a model of aging induced with D-galactose.
Feb 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharmacopuncture. 2017 Mar ;20(1):29-35. PMID:
28392960
Article Published Date
: Feb 28, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Nigella sativa (aka Black Seed)
Diseases
:
Aging
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Butterbur leaves attenuate memory impairment and neuronal cell damage in amyloid beta-induced Alzheimer’s disease models.
May 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2018 Jun 1 ;19(6). Epub 2018 Jun 1. PMID:
29865187
Article Published Date
: May 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Butterbur
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
[+]
C. asiatica treatment helps to prevent cerebral damage and maintain near normal cerebral function in diabetes.
Jun 24, 2020
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2020 Jun 25. Epub 2020 Jun 25. PMID:
32588370
Article Published Date
: Jun 24, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Gotu Kola
Diseases
:
Brain: Oxidative Stress
,
Brain Inflammation
,
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
C. sinensis can improve the dysfunction of gut barrier in septic rats by promoting the proliferation and inhibiting the apoptosis of intestinal mucosal cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Med. 2015 ;8(5):7333-41. Epub 2015 May 15. PMID:
26221273
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cordyceps sinensis
Diseases
:
Sepsis
Pharmacological Actions
:
Anti-Apoptotic
,
Gastroprotective
[+]
Caffeic acid phenethyl ester has a protective effect against sevoflurane induced neurotoxicity in neonatal rats.
Aug 03, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Aug 4. Epub 2016 Aug 4. PMID:
27498600
Article Published Date
: Aug 03, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Caffeic acid phenethyl ester
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
Problem Substances
:
Anaesthetic Gases
[+]
Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload.
Jan 31, 2014
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2014 Feb ;49(1):222-33. Epub 2013 Jul 28. PMID:
23893294
Article Published Date
: Jan 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Iron Overload
,
Neurodegenerative Diseases
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Cannabidiol possesses an anti-apoptotic power against the neurodegenerative processes underlying MS development.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: Eur Rev Med Pharmacol Sci. 2015 Dec ;19(24):4906-19. PMID:
26744883
Article Published Date
: Nov 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Multiple Sclerosis
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Cannabidiol reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke.
Dec 20, 2016
Click here to read the entire abstract
Pubmed Data
: Neuropharmacology. 2016 Dec 21. Epub 2016 Dec 21. PMID:
28012949
Article Published Date
: Dec 20, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Cardamonin protects against adverse cardiac remodeling through mTORC1 inhibition in mice with myocardial infarction.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Pharmazie. 2018 09 1 ;73(9):508-512. PMID:
30223933
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Cardamonin
Diseases
:
Cardiomegaly
,
Myocardial Infarction
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Carnosic acid attenuates arsenic-induced hepatotoxicity.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2018 ;2018:1421438. Epub 2018 May 2. PMID:
29854073
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Carnosic Acid
Diseases
:
Chemically-Induced Liver Damage
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
Problem Substances
:
Arsenic
[+]
Carnosic acid may represent a novel therapeutic strategy to treat metabolic disease induced brain injury.
Jun 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2019 Jul ;20(1):495-504. Epub 2019 May 27. PMID:
31180544
Article Published Date
: Jun 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Carnosic Acid
Diseases
:
Brain Inflammation
,
High Fat Diet
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
[+]
Carnosic acid mitigates early brain injury after subarachnoid hemorrhage.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Neurosci. 2019 ;13:26. Epub 2019 Mar 5. PMID:
30890904
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Carnosic Acid
Diseases
:
Subarachnoid hemorrhage
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Carnosine may provide neuroprotective effect after experimental intracerebral hemorrhage.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2017 Feb ;42(2):541-551. Epub 2016 Nov 21. PMID:
27868153
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Carnosine
Diseases
:
Cerebral Hemorrhage
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
[+]
Carnosol protects against renal ischemia-reperfusion injury in rats.
Oct 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Anim. 2018 Nov 1 ;67(4):545-553. Epub 2018 Jul 31. PMID:
30068825
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Carnosol
Diseases
:
Ischemia
,
Kidney Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Renoprotective
[+]
Carvacrol alleviates ethanol-mediated hippocampal neuronal impairment by antioxidative and antiapoptotic effects.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2017 ;2017:4079425. Epub 2017 Jan 16. PMID:
28191274
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Carvacrol
Diseases
:
Alcohol Toxicity
,
Cognitive Decline/Dysfunction
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
[+]
Carvacrol and pomegranate decrease methotrexate related damage and apoptotic activity in intestinal tissue.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Clin Exp Med. 2015;8(9):15474-15481. Epub 2015 Sep 15. PMID:
26629037
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Carvacrol
,
Pomegranate
Diseases
:
Drug-Induced Toxicity: Methotrexate
Pharmacological Actions
:
Anti-Apoptotic
,
Gastroprotective
[+]
Celastrol alleviates chronic obstructive pulmonary disease by inhibiting cellular inflammation induced by cigarette smoke.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2018 ;9:1276. Epub 2018 Nov 15. PMID:
30498444
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Celastrol
Diseases
:
Chronic Obstructive Pulmonary Disease
,
Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-8 downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Cerebral ischemia was protected by oleuropein.
Sep 18, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Sci Monit. 2018 Sep 19 ;24:6587-6598. Epub 2018 Sep 19. PMID:
30230477
Article Published Date
: Sep 18, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Oleuropein
Diseases
:
Brain Ischemia
,
Middle Cerebral Artery Occlusion (MCAO)
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Chemoprotective role of an extract of the heart of the Phoenix dactylifera tree on adriamycin-induced cardiotoxicity and nephrotoxicity.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Chem Toxicol. 2020 Jan ;135:111045. Epub 2019 Dec 9. PMID:
31830546
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Dates
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
Chemoprotective Agents
,
Renoprotective
Additional Keywords
:
Plant Extracts
[+]
Chlorogenic acid ameliorates alcohol-induced liver injuries through scavenging reactive oxygen species.
Jun 30, 2018
Click here to read the entire abstract
Pubmed Data
: Biochimie. 2018 Jul ;150:131-138. Epub 2018 May 19. PMID:
29787793
Article Published Date
: Jun 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Chlorogenic Acid
Diseases
:
Alcohol Toxicity
,
Alcoholic Liver Disease
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
[+]
Chlorogenic acid ameliorates experimental colitis.
Oct 31, 2018
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2018 Nov ;121:140-150. Epub 2018 Aug 27. PMID:
30165128
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Chlorogenic Acid
Diseases
:
Colitis
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
[+]
Chlorogenic acid attenuates dextran sodium sulfate-induced ulcerative colitis.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2019 ;2019:6769789. Epub 2019 Apr 18. PMID:
31139644
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Chlorogenic Acid
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
[+]
Chlorogenic acid could be a potential therapeutic to minimize sodium arsenite-induced hepatic injury.
Jan 31, 2020
Click here to read the entire abstract
Pubmed Data
: Mol Biol Rep. 2020 Feb ;47(2):1161-1171. Epub 2019 Dec 9. PMID:
31820315
Article Published Date
: Jan 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Chlorogenic Acid
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Hepatoprotective
Problem Substances
:
Arsenic
[+]
Chlorogenic acid supplementation may be favourable to avoid aluminium induced hematotoxicity and hepatotoxicity for humans.
Jul 31, 2017
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2017 Aug 1 ;273:125-132. Epub 2017 Jun 13. PMID:
28623112
Article Published Date
: Jul 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Chlorogenic Acid
Diseases
:
Aluminum Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Hepatoprotective
Problem Substances
:
Aluminum
[+]
Chrysin can serve as a potential therapeutic agent on 3-Nitropropionic acid induced mitochondrial deficits and subsequent apoptosis.
Sep 26, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Sep 27 ;84:514-525. Epub 2016 Aug 27. PMID:
27690136
Article Published Date
: Sep 26, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Huntington Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Chrysin could be beneficial for protection against traumatic brain injury-associated behavioural deficits.
Feb 21, 2020
Click here to read the entire abstract
Pubmed Data
: Psychopharmacology (Berl). 2020 Feb 22. Epub 2020 Feb 22. PMID:
32088834
Article Published Date
: Feb 21, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Memory Disorders
,
Traumatic Brain Injury
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Chrysin improved several behavioural, cognitive and neurochemical parameters in a relevant preclinical model of Parkinson's disease.
Jan 26, 2019
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2019 07 27 ;706:158-163. Epub 2019 May 20. PMID:
31121284
Article Published Date
: Jan 26, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Parkinson's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
[+]
Chrysin possesses restorative effect against paracetamol induced hepatotoxicity.
Oct 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2017 Nov ;31(11). Epub 2017 Jul 6. PMID:
28682524
Article Published Date
: Oct 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Lipid Peroxidation
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Acetaminophen (Tylenol) Toxicity
,
Anti-Apoptotic
,
Antioxidants
,
Chrysin
,
Hepatoprotective
,
Lipid Peroxidation
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Chrysin protects against renal ischemia reperfusion induced tubular cell apoptosis and inflammation.
Feb 28, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Mar ;17(3):2256-2262. Epub 2019 Jan 21. PMID:
30867710
Article Published Date
: Feb 28, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Chrysin protects human osteoarthritis chondrocytes by inhibiting inflammatory mediator expression.
Jan 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2019 Feb ;19(2):1222-1229. Epub 2018 Dec 4. PMID:
30535473
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Inflammation
,
Osteoarthritis
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
[+]
Co-administration of curcumin and piperine may provide a useful natural adjuvant in the antidepressant therapy.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(4):e61052. Epub 2013 Apr 17. PMID:
23613781
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Piperine
Diseases
:
Depression
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antidepressive Agents
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Co-treatment with anthocyanins and vitamin C may be a new and potentially effective neuroprotective agent for alcohol abuse.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: CNS Neurol Disord Drug Targets. 2015 ;14(6):791-803. PMID:
25714970
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
,
Vitamin C
Diseases
:
Alcohol Toxicity
,
DNA damage
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Genoprotective
,
Neuroprotective Agents
[+]
Cocoa ameliorates renal injury in Zucker diabetic fatty rats by preventing oxidative stress, apoptosis and inactivation of autophagy.
Dec 10, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Food Funct. 2019 Dec 11 ;10(12):7926-7939. PMID:
31773121
Article Published Date
: Dec 10, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Cocoa
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Renoprotective
[+]
Coconut oil protects against light-induced retina degeneration in male Wistar rats.
Oct 04, 2018
Click here to read the entire abstract
Pubmed Data
: Pathophysiology. 2018 Oct 5. Epub 2018 Oct 5. PMID:
30309759
Article Published Date
: Oct 04, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Coconut Oil
Diseases
:
Retinal Degeneration: Light-Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidant
[+]
Coenzyme Q10 has beneficial effects against lead-induced neuronal damage.
Aug 12, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Environ Res Public Health. 2019 Aug 13 ;16(16). Epub 2019 Aug 13. PMID:
31412628
Article Published Date
: Aug 12, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
Diseases
:
Lead Poisoning
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
Problem Substances
:
Lead
[+]
Coenzyme Q10 influences on the levels of TNF-α and IL-10 and the ratio of Bax/Bcl2 in a menopausal rat model following lumbar spinal cord injury.
May 31, 2018
Click here to read the entire abstract
Pubmed Data
: J Mol Neurosci. 2018 Jun ;65(2):255-264. Epub 2018 Jun 14. PMID:
29948851
Article Published Date
: May 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Bax/Bcl2 Ratio: Decrease
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Coenzyme Q10 reduces the deleterious cellular side effects of lead acetate.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Physiol. 2020 ;11:64. Epub 2020 Feb 7. PMID:
32116774
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
Diseases
:
Kidney Damage: Chemically-Induced
,
Lead Poisoning
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Renoprotective
Problem Substances
:
Lead
[+]
Coenzyme Q10 regulates antioxidative stress and autophagy in acute myocardial ischemia-reperfusion injury.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2017 ;2017:9863181. Epub 2017 Nov 19. PMID:
29348792
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Coenzyme Q10
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Cardioprotective
[+]
Combinatorial usage of fungal polysaccharides from Cordyceps sinensis and Ganoderma atrum ameliorate drug-induced liver injury in mice.
Aug 31, 2018
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2018 Sep ;119:66-72. Epub 2018 May 16. PMID:
29753871
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cordyceps sinensis
,
Medicinal Mushrooms
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
,
Liver Damage: Drug-Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
Additional Keywords
:
Polysaccharides
[+]
Components of Astragalus and Panax notoginseng could strengthen the protective effects on cerebral ischemia injury.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2015 ;43(7):1419-38. Epub 2015 Oct 18. PMID:
26477799
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Astragalus
,
Ginsenosides
,
Panax Notoginseng
Diseases
:
Brain Ischemia
,
Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
[+]
Components of star fruit have potential benefit on treating learning and memory deficit in APP/PS1 transgenic Alzheimer's disease mice.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2018 ;49(3):1064-1073. Epub 2018 Sep 7. PMID:
30196278
Article Published Date
: Dec 31, 2017
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Star Fruit
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Bcl-2 protein down-regulation
,
Neuroprotective Agents
[+]
Compound K protects pancreatic islet cells against apoptosis
Jun 26, 2014
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2014 Jun 27 ;107(1-2):42-9. Epub 2014 May 5. PMID:
24802125
Article Published Date
: Jun 26, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Apoptotic
,
Pancreato Protective Agents
[+]
Cordycepin exhibits a suppressive effect on T cells through inhibiting TCR signalling cascade in CFA-induced inflammation Mice model.
Mar 31, 2020
Click here to read the entire abstract
Pubmed Data
: Immunopharmacol Immunotoxicol. 2020 Apr ;42(2):119-127. Epub 2020 Feb 27. PMID:
32105161
Article Published Date
: Mar 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Cordyceps Militaris
Diseases
:
Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-2 Downregulation
[+]
Cordycepin protects renal ischemia/reperfusion injury through regulating inflammation, apoptosis, and oxidative stress.
Jan 16, 2020
Click here to read the entire abstract
Pubmed Data
: Acta Biochim Biophys Sin (Shanghai). 2020 Jan 17. Epub 2020 Jan 17. PMID:
31951250
Article Published Date
: Jan 16, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Cordyceps Militaris
Diseases
:
Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Renoprotective
[+]
Cordyceps showed therapeutic effects through inhibiting cerebral ischemia-induced apoptosis in the hippocampus.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Exerc Rehabil. 2016 Apr ;12(2):69-78. Epub 2016 Apr 26. PMID:
27162767
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cordyceps Militaris
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Cordyceps sinensis could protect pancreatic beta cells from the pro-apoptotic endoplasmic reticulum stress induced by HFD-STZ.
Apr 28, 2016
Click here to read the entire abstract
Pubmed Data
: Can J Diabetes. 2016 Apr 29. Epub 2016 Apr 29. PMID:
27140306
Article Published Date
: Apr 28, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Cordyceps sinensis
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Apoptotic
,
Hypoglycemic Agents
,
Pancreato Protective Agents
[+]
Cordyceps supplementation prevents adverse effects of electromagnetic pulse irradiation on sperm quality.
Jan 01, 2017
Click here to read the entire abstract
Pubmed Data
: OMICS. 2017 02 ;21(2):81-89. PMID:
28186865
Article Published Date
: Jan 01, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Selenium
Diseases
:
Oxidative Stress
,
Sperm Count: Low
,
Sperm Quality: Low
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidant
,
Cytoprotective
Anti Therapeutic Actions
:
Electromagnetic Field Harms
,
Electromagnetic Radiation
[+]
Coumestrol treatment has potential benefits for either prevention or therapeutics use against cerebral ischemia in males.
Feb 28, 2014
Click here to read the entire abstract
Pubmed Data
: Neurol Res. 2014 Mar ;36(3):198-206. PMID:
24512013
Article Published Date
: Feb 28, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Coumestrol
Diseases
:
Brain Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Crocetin may be used as a novel therapy for preventing fulminant hepatic failure.
Oct 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2019 Nov ;18(5):3775-3782. Epub 2019 Sep 19. PMID:
31616509
Article Published Date
: Oct 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Crocetin
Diseases
:
Fulminant Hepatic Failure
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
[+]
Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system.
Apr 30, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 May ;101:174-180. Epub 2018 Feb 24. PMID:
29486335
Article Published Date
: Apr 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Crocin
Diseases
:
Chemotherapy-Induced Toxicity: Cyclophosphamide
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Apoptotic
[+]
Crocin can improve the synaptic loss and neuronal death.
Jun 09, 2020
Click here to read the entire abstract
Pubmed Data
: J Chem Neuroanat. 2020 Jun 10:101837. Epub 2020 Jun 10. PMID:
32534024
Article Published Date
: Jun 09, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Crocin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Crocin demonstrates good prospects in the treatment of Alzheimer's disease through the oxidative stress associated apoptosis signalling pathway.
Dec 17, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2018 Dec 18. Epub 2018 Dec 18. PMID:
30569175
Article Published Date
: Dec 17, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Crocin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
[+]
Crocin has a cardioprotective effect against DOX-induced cardiomayopathy.
Mar 04, 2016
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2016 Mar 5 ;247:39-48. Epub 2016 Jan 22. PMID:
26807765
Article Published Date
: Mar 04, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Crocin
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cardioprotective
[+]
Crocin has protective activities against ethanol toxic effects in the liver and kidney.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2020 Jan ;23(1):51-62. PMID:
32405348
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Crocin
Diseases
:
Alcohol Toxicity
,
Alcoholic Liver Disease
,
Chemically-Induced Liver Damage
,
Kidney Damage: Chemically-Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
,
Interleukin-6 Downregulation
,
Renoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Crocin improves cognitive behavior in rats with Alzheimer's disease.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2019 ;2019:9454913. Epub 2019 Aug 26. PMID:
31534969
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Crocin
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Crocin may exert antiapoptotic, antioxidant and protective effects in IR-mediated brain injury induced by four-vessel occlusion.
Apr 22, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Apr 23. Epub 2016 Apr 23. PMID:
27117584
Article Published Date
: Apr 22, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Crocin
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
[+]
Crocin reduced the toxic effects of diazinon by inhibiting apoptosis in aortic tissue.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Toxicol Ind Health. 2016 Jul ;32(7):1237-45. Epub 2014 Nov 20. PMID:
27353299
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Crocin
Diseases
:
Pesticide-Induced Toxicity: Organophosphates
Pharmacological Actions
:
Anti-Apoptotic
,
Cytoprotective
Problem Substances
:
Organophosphates
[+]
Curcumin ameliorated myocardial infarction by inhibition of cardiotoxicity.
Feb 17, 2019
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2019 Feb 18. Epub 2019 Feb 18. PMID:
30775806
Article Published Date
: Feb 17, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cardiovascular Diseases
,
Myocardial Infarction
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Curcumin ameliorates doxorubicin-induced cardiotoxicity.
Jan 31, 2018
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2018 Feb ;32(2). Epub 2018 Jan 5. PMID:
29315967
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
,
Cyclooxygenase 2 Inhibitors
[+]
Curcumin and resveratrol effectively prevent benzo(a)pyrene induced testicular germ cell apoptosis and restore male reproductive health.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2016 ;7:245. Epub 2016 Aug 8. PMID:
27551266
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Resveratrol
Pharmacological Actions
:
Anti-Apoptotic
,
Bax/Bcl2 Ratio: Decrease
Additional Keywords
:
Natural Substance Synergy
Problem Substances
:
Benzo(a)pyrene
[+]
Curcumin attenuates high glucose-induced podocyte apoptosis in vitro and diabetic nephropathy in vivo.
Jan 31, 2016
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2016 Feb 1. Epub 2016 Feb 1. PMID:
26838071
Article Published Date
: Jan 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Renoprotective
Additional Keywords
:
Dose Response
[+]
Curcumin attenuates rat thoracic aortic aneurysm formation.
Sep 30, 2012
Click here to read the entire abstract
Pubmed Data
: Nutrition. 2012 Oct ;28(10):1068-74. Epub 2012 Jul 26. PMID:
22840386
Article Published Date
: Sep 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Anti-Apoptotic
,
Bax/Bcl2 Ratio: Decrease
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Curcumin can attenuate the downregulation of CISD2 in spinal cord injuries and LPS-treated astrocytes.
Aug 07, 2015
Click here to read the entire abstract
Pubmed Data
: Injury. 2015 Aug 8. Epub 2015 Aug 8. PMID:
26387034
Article Published Date
: Aug 07, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Brain Inflammation
,
Spinal Cord Injuries
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
MicroRNA modulator
,
Neuroprotective Agents
[+]
Curcumin had protective effects against cerebral ischemia/reperfusion injury in animals.
Dec 10, 2015
Click here to read the entire abstract
Pubmed Data
: Microvasc Res. 2015 Dec 11. Epub 2015 Dec 11. PMID:
26686249
Article Published Date
: Dec 10, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Brain Edema
,
Cerebral Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Nrf2 activation
[+]
Curcumin has a protective effect against cadmium-induced apoptosis in rat testes.
Feb 29, 2012
Click here to read the entire abstract
Pubmed Data
: Toxicol Ind Health. 2012 Mar ;28(2):122-30. Epub 2011 Jun 1. PMID:
21632575
Article Published Date
: Feb 29, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Infertility: Male
,
Testicular Injury: Cadmium-Induced
Pharmacological Actions
:
Anti-Apoptotic
[+]
Curcumin has anti-apoptotic properties in a transgenic amyotrophic lateral sclerosis mice.
May 31, 2005
Click here to read the entire abstract
Pubmed Data
: J Neurochem. 2005 Jun ;93(5):1087-98. PMID:
15934930
Article Published Date
: May 31, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Amyotrophic Lateral Sclerosis
Pharmacological Actions
:
Anti-Apoptotic
,
Bcl-2 protein down-regulation
,
NF-kappaB Inhibitor
[+]
Curcumin improves outcomes and attenuates focal cerebral ischemic injury.
Mar 01, 2010
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2010 Mar;35(3):374-9. Epub 2009 Sep 23. PMID:
19774461
Article Published Date
: Mar 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cerebral Ischemia
,
Middle Cerebral Artery Occlusion (MCAO)
,
Oxidative Stress
,
Stroke: Recovery
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
[+]
Curcumin intervention effectively reversed the Fas/FasL-mediated apoptosis and hypoxia-hypercapnia brain edema.
May 31, 2015
Click here to read the entire abstract
Pubmed Data
: Am J Med Sci. 2015 Jun ;349(6):521-5. PMID:
25867253
Article Published Date
: May 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Brain Hypoxia
,
Hypercapnia
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Curcumin might be used to prevent neuronal damage in the retina of patients with diabetes mellitus.
Jul 23, 2015
Click here to read the entire abstract
Pubmed Data
: J Ocul Pharmacol Ther. 2015 Jul 24. Epub 2015 Jul 24. PMID:
26207889
Article Published Date
: Jul 23, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Diabetes Mellitus: Type 1
,
Diabetic Complications
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Curcumin pretreatment is a promising adjuvant strategy for stem cells transplantation in myocardial restoration.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Stem Cells Int. 2015 ;2015:638153. Epub 2015 May 5. PMID:
26074974
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Ischemia: Myocardial
,
Oxidative Stress
Pharmacological Actions
:
Angiogenesis Inducing Agents
,
Anti-Apoptotic
,
Antioxidants
,
Heme oxygenase-1 up-regulation
Additional Keywords
:
Mesenchymal Stem Cells
[+]
Curcumin prevents chronic intermittent hypoxia-induced myocardial injury.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Ther Adv Chronic Dis. 2020 ;11:2040622320922104. Epub 2020 Jun 24. PMID:
32637058
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Hypoxia
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Cardioprotective
,
Hypoxia-inducible factor-1 (HIF-1) inhibitor
[+]
Curcumin prevents hyperoxia-induced neonatal lung injury long-term, suggesting its potential usefulness in preventing bronchopulmonary dysplasia.
Aug 14, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15 ;305(4):L301-11. Epub 2013 Jun 28. PMID:
23812632
Article Published Date
: Aug 14, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Bronchopulmonary Dysplasia
,
Hypoxia
,
Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Cytoprotective
[+]
Curcumin prevents the NASH by mitochondria protection and apoptosis reduction and provided a possible novel treatment for NASH.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Int J Clin Exp Pathol. 2015 ;8(9):11503-9. Epub 2015 Sep 1. PMID:
26617882
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions
:
Anti-Apoptotic
,
Hepatoprotective
[+]
Curcumin protects against acetaminophen-induced toxicity.
Jan 16, 2012
Click here to read the entire abstract
Pubmed Data
: Curr Neurovasc Res. 2012 Jan 16. Epub 2012 Jan 16. PMID:
22272768
Article Published Date
: Jan 16, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Apoptotic
,
Hepatoprotective
[+]
Curcumin reduces high glucose induced neural tube defects by blocking cellular stress and caspase activation.
May 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Obstet Gynecol. 2015 Jun ;212(6):802.e1-8. Epub 2015 Jan 13. PMID:
25595578
Article Published Date
: May 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Diabetes: Oxidative Stress
,
Diabetic Complications
,
Neural Tube Defects
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
[+]
Curcumin reduces production of ROS and inflammatory mediators in HIV-1-gp120-stimulated microglia, and protects cortical neurons against HIV-1-mediated apoptosis.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(8):e70565. Epub 2013 Aug 6. PMID:
23936448
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
HIV Infections
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Neuroprotective Agents
[+]
Curcumin treatment has a protective effect against intestinal damage induced by bile duct ligation.
Dec 17, 2015
Click here to read the entire abstract
Pubmed Data
: J Invest Surg. 2015 Dec 18:1-9. Epub 2015 Dec 18. PMID:
26682581
Article Published Date
: Dec 17, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cholestasis
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Gastroprotective
[+]
Cyanidin ameliorates endotoxin-induced myocardial toxicity.
Sep 30, 2018
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2018 Oct ;120:104-111. Epub 2018 May 25. PMID:
29803697
Article Published Date
: Sep 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cyanidin
Diseases
:
Endotoxemia
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Cardioprotective
[+]
Cyanidin-3- O-glucoside at low doses protected against 3-chloro-1,2-propanediol induced testis injury.
Dec 04, 2018
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2018 Dec 5 ;66(48):12675-12684. Epub 2018 Oct 30. PMID:
30376326
Article Published Date
: Dec 04, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cyanidin 3-glucoside
Diseases
:
Oxidative Stress
,
Sperm Quality: Low
,
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Apoptotic
Additional Keywords
:
Plant Extracts
[+]
Cyanidin-3-glucoside inhibits amyloid β25-35-induced neuronal cell death in cultured rat hippocampal neurons.
Oct 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Korean J Physiol Pharmacol. 2018 Nov ;22(6):689-696. Epub 2018 Oct 25. PMID:
30402029
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Cyanidin 3-glucoside
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
Deep-sea water containing selenium provides intestinal protection against duodenal ulcers.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2014 ;9(7):e96006. Epub 2014 Jul 1. PMID:
24984066
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Selenium
,
Water: Deep Sea
Diseases
:
Duodenal Ulcer
Pharmacological Actions
:
Anti-Apoptotic
[+]
Diallyl sulfide protects against lipopolysaccharide/d-galactosamine-induced acute liver injury.
Jul 30, 2018
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2018 Jul 31 ;120:500-509. Epub 2018 Jul 31. PMID:
30075314
Article Published Date
: Jul 30, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Diallyl sulfide
Diseases
:
Lipopolysaccharide-Induced Toxicity
,
Liver Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Diallyl sulfide seemed to be a promising agent for protection against lead-induced testicular toxicity.
Apr 11, 2019
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2019 Apr 12. Epub 2019 Apr 12. PMID:
30986445
Article Published Date
: Apr 11, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Diallyl sulfide
Diseases
:
Testicular Injury: Chemical/Metal Induced
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Problem Substances
:
Lead
[+]
Diallyl trisulfide suppresses oxidative stress-induced activation of hepatic stellate cells.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2017 ;2017:1406726. Epub 2017 Feb 20. PMID:
28303169
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Garlic
Diseases
:
Liver Cirrhosis
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
Additional Keywords
:
Anti-Apoptotic
,
Antioxidants
,
Garlic
,
Liver Cirrhosis
,
oxidative stress
[+]
Dietary cocoa powder improves hyperlipidemia and reduces atherosclerosis.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mediators Inflamm. 2016 ;2016:1937572. Epub 2016 Feb 15. PMID:
26980943
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Cocoa
Diseases
:
Atherosclerosis
,
Hyperlipidemia
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Hypolipidemic
[+]
Dietary pomegranate supplement alleviates murine pancreatitis.
Dec 20, 2018
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2018 Dec 21 ;66:17-28. Epub 2018 Dec 21. PMID:
30708236
Article Published Date
: Dec 20, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Pomegranate
Diseases
:
Pancreatitis
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Nrf2 activation
,
Pancreato Protective Agents
[+]
Dietary supplementation of barley and/or dates attenuate hypercholesterolemic-induced endometrial dysfunction in Wistar albino rats via alleviation of apoptotic pathways and enhancing oxidative capacity.
Nov 01, 2019
Click here to read the entire abstract
Pubmed Data
: J Food Biochem. 2019 Nov ;43(11):e13001. Epub 2019 Aug 1. PMID:
31373029
Article Published Date
: Nov 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Barley
,
Dates
Diseases
:
Hypercholesterolemia
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidant
[+]
Dietary walnut reduces hepatic triglyceride content in high-fat-fed mice
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nutr Biochem. 2016 Apr ;30:116-25. Epub 2016 Jan 6. PMID:
27012628
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Walnut
Diseases
:
High Fat Diet
,
Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Hepatoprotective
,
Hypolipidemic
[+]
Dietary zerumbone ameliorates hepatotoxin-mediated acute and chronic liver injury.
Apr 30, 2019
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2019 May ;33(5):1538-1550. Epub 2019 Mar 14. PMID:
30868670
Article Published Date
: Apr 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Zerumbone
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Hepatoprotective
[+]
Diosgenin attenuates the brain injury induced by transient focal cerebral ischemia-reperfusion.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Steroids. 2016 09 ;113:103-12. Epub 2016 Jul 16. PMID:
27425638
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Diosgenin
Diseases
:
Brain Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Diosgenin can inhibit apoptosis and increase mitochondrial oxidative stress capacity of chondrocytes in mice with osteoarthritis.
May 24, 2016
Click here to read the entire abstract
Pubmed Data
: Zhejiang Da Xue Xue Bao Yi Xue Ban. 2016 May 25 ;45(5):453-460. PMID:
28087904
Article Published Date
: May 24, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Diosgenin
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Osteoprotective
,
Superoxide Dismutase Up-regulation
[+]
Diosgenin is a potential therapeutic agent to mitigate vascular dysfunction in diabetes mellitus.
Nov 30, 2015
Click here to read the entire abstract
Pubmed Data
: J Cardiovasc Pharmacol. 2015 Dec ;66(6):584-92. PMID:
26309100
Article Published Date
: Nov 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Diosgenin
Diseases
:
Endothelial Dysfunction
Pharmacological Actions
:
Anti-Apoptotic
,
NF-kappaB Inhibitor
[+]
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure.
May 08, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2017 May 9 ;8(19):30723-30733. PMID:
28430612
Article Published Date
: May 08, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Diosmetin
Diseases
:
Endotoxemia
,
Liver Damage
,
Liver Failure: Acute
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
NF-kappaB Inhibitor
[+]
Diosmetin reduced neuroinflammation and neuronal apoptosis in a model of pneumococcal meningitis.
Mar 26, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Sci Monit. 2019 Mar 27 ;25:2238-2245. Epub 2019 Mar 27. PMID:
30914630
Article Published Date
: Mar 26, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Diosmetin
Diseases
:
Inflammation
,
Meningitis: Bacterial
,
Pneumococcal Infections
,
Streptococcus pneumoniae infection
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
NF-kappaB Inhibitor
[+]
Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion.
Aug 04, 2014
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2014 Aug 5 ;736:131-7. Epub 2014 Apr 24. PMID:
24769512
Article Published Date
: Aug 04, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Diosmin
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Cardioprotective
,
Superoxide Dismutase Up-regulation
[+]
Early use of fucoidan in diabetic individuals may minimize damage to testicular tissue.
Mar 06, 2018
Click here to read the entire abstract
Pubmed Data
: Biotech Histochem. 2018 Mar 7:1-9. Epub 2018 Mar 7. PMID:
29513110
Article Published Date
: Mar 06, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Diabetic Complications
Pharmacological Actions
:
Anti-Apoptotic
[+]
Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats.
Oct 31, 2019
Click here to read the entire abstract
Pubmed Data
: Naunyn Schmiedebergs Arch Pharmacol. 2019 Nov ;392(11):1383-1391. Epub 2019 Jun 24. PMID:
31236657
Article Published Date
: Oct 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Oleuropein
Diseases
:
Cognitive Decline/Dysfunction
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Neuroprotective Agents
Problem Substances
:
Morphine
[+]
Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver.
Oct 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2017 Nov ;14(5):4639-4646. Epub 2017 Sep 21. PMID:
29201162
Article Published Date
: Oct 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Tanshinone IIA
Diseases
:
Fatty Liver
,
Liver Steatosis
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
,
Malondialdehyde Down-regulation
[+]
Effects of alpha-lipoic acid on high fructose induced hepatic pathology.
Jan 10, 2019
Click here to read the entire abstract
Pubmed Data
: Biotech Histochem. 2019 Jan 11:1-6. Epub 2019 Jan 11. PMID:
30632398
Article Published Date
: Jan 10, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Alpha-Lipoic Acid
Diseases
:
Chemically-Induced Liver Damage
,
High Fructose Diet
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Hepatoprotective
Problem Substances
:
High Fructose Corn Syrup
[+]
Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats.
Mar 29, 2017
Click here to read the entire abstract
Pubmed Data
: Genet Mol Res. 2017 Mar 30 ;16(1). Epub 2017 Mar 30. PMID:
28362999
Article Published Date
: Mar 29, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Diabetes Mellitus: Type 2
Pharmacological Actions
:
Anti-Apoptotic
,
Hepatoprotective
,
Hypoglycemic Agents
,
Hypolipidemic
[+]
Effects of resveratrol on learning and memory in rats with vascular dementia.
Oct 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2019 Nov ;20(5):4587-4593. Epub 2019 Oct 2. PMID:
31702039
Article Published Date
: Oct 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Dementia
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
[+]
EGb761 reduces neuronal apoptosis and promotes angiogenesis in experimental intracerebral hemorrhage.
Feb 08, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Neurobiol. 2017 Feb 9. Epub 2017 Feb 9. PMID:
28185127
Article Published Date
: Feb 08, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Intracerebral Hemorrhage
Pharmacological Actions
:
Angiogenesis Inducing Agents
,
Anti-Apoptotic
,
Neuroprotective Agents
Additional Keywords
:
Plant Extracts
[+]
EGCG could be used in the prevention or in the therapy of anthrax infections.
Mar 31, 2004
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: EMBO Rep. 2004 Apr ;5(4):418-22. Epub 2004 Mar 12. PMID:
15031715
Article Published Date
: Mar 31, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
EGCG (Epigallocatechin gallate)
,
Green Tea
Diseases
:
Anthrax
Pharmacological Actions
:
Anti-Apoptotic
,
Matrix Metalloproteinases Inhibitors
Additional Keywords
:
Anthrax Lethal Factor
[+]
EGCG exerts a neuroprotective effect on experimental autoimmune thyroiditis.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Jan ;15(1):1087-1092. Epub 2017 Nov 14. PMID:
29434699
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Autoimmune Thyroiditis
,
Thyroiditis: Autoimmune
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
[+]
EGCG might be regarded as a prospective therapeutic candidate in modulating diabetic nephropathy.
Aug 20, 2017
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2017 Aug 21. Epub 2017 Aug 21. PMID:
28823168
Article Published Date
: Aug 20, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Fibrotic
,
Hypoglycemic Agents
[+]
EGCG treatment can decrease renal ischemia-reperfusion injury by suppressing inflammation and cell apoptosis.
Jun 27, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int Urol Nephrol. 2015 Jun 28. Epub 2015 Jun 28. PMID:
26122117
Article Published Date
: Jun 27, 2015
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Kidney Damage
,
Kidney Diseases
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Renoprotective
Additional Keywords
:
Significant Treatment Outcome
[+]
Electroacupuncture inhibits neuronal autophagy and apoptosis via the PI3K/AKT Pathway following ischemic stroke.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Cell Neurosci. 2020 ;14:134. Epub 2020 May 15. PMID:
32477073
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Diseases
:
Stroke: Ischemic
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Anti-Apoptotic
,
Autophagy Inhibitors
,
Neuroprotective Agents
[+]
Electroacupuncture pre-treatment alleviates sepsis-induced brain injury by inhibition of microglial activation and attenuation of inflammation.
Oct 18, 2016
Click here to read the entire abstract
Pubmed Data
: Brain Res Bull. 2016 Oct 19 ;127:248-259. Epub 2016 Aug 19. PMID:
27771396
Article Published Date
: Oct 18, 2016
Study Type
: Animal Study
Additional Links
Diseases
:
Brain: Microglial Activation
,
Brain Inflammation
,
Sepsis
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Catalase Up-Regulation
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Neuroprotective Agents
,
Superoxide Dismutase Up-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Electroacupuncture pretreatment enhances STAT3 activation via CB1R to protect against cerebral ischemia.
Sep 04, 2013
Click here to read the entire abstract
Pubmed Data
: Brain Res. 2013 Sep 5 ;1529:154-64. Epub 2013 Jul 20. PMID:
23880371
Article Published Date
: Sep 04, 2013
Study Type
: Animal Study
Additional Links
Diseases
:
Cerebral Ischemia
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Anti-Apoptotic
,
Neuroprotective Agents
,
STAT3 Activation
Additional Keywords
:
Cannabinoid Receptors
[+]
Electroacupuncture stimulation of PC6 and HT7 can inhibit cerebral ischemia injury induced cell apoptosis of cerebral and myocardial tissues.
Feb 24, 2019
Click here to read the entire abstract
Pubmed Data
: Zhen Ci Yan Jiu. 2019 Feb 25 ;44(2):107-12. PMID:
30945486
Article Published Date
: Feb 24, 2019
Study Type
: Animal Study
Additional Links
Diseases
:
Cerebral Ischemia
Therapeutic Actions
:
Electroacupuncture
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
Neuroprotective Agents
[+]
Ellagic acid ameliorates renal ischemic-reperfusion injury.
Nov 25, 2019
Click here to read the entire abstract
Pubmed Data
: Inflammation. 2019 Nov 26. Epub 2019 Nov 26. PMID:
31768706
Article Published Date
: Nov 25, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Ischemia
,
Kidney Damage
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Renoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Ellagic acid improved ventricular remodelling after myocardial infarction by up-regulating miR-140-3p expression and inhibiting MKK6 expression.
Oct 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Nov ;95:983-989. Epub 2017 Sep 12. PMID:
28922712
Article Published Date
: Oct 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
MicroRNA modulator
[+]
Ellagic acid treatment attenuates gentamicin induced nephrotoxicity.
Jun 29, 2016
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2016 Jun 30. Epub 2016 Jun 30. PMID:
27364420
Article Published Date
: Jun 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions
:
Anti-Apoptotic
,
Antioxidants
,
Renoprotective
[+]
Emblica officinalis could be a promising therapeutic aid against aluminium-induced neurotoxicity.
Jan 31, 2019
Click here to read the entire abstract
Pubmed Data
: Neurotox Res. 2019 Feb ;35(2):318-330. Epub 2018 Sep 21. PMID:
30242626
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Amla Fruit
Diseases
:
Aluminum Toxicity
,
Brain Inflammation
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Neuroprotective Agents
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Plant Extracts
Problem Substances
:
Aluminum
[+]
Endurance exercise may exert neuroprotective effects by mitigating the production of pro-inflammatory cytokines.
Mar 15, 2016
Click here to read the entire abstract
Pubmed Data
: J Neuroendocrinol. 2016 Mar 16. Epub 2016 Mar 16. PMID:
26991447
Article Published Date
: Mar 15, 2016
Study Type
: Animal Study
Additional Links
Diseases
:
Brain Inflammation
,
High Fat Diet
Therapeutic Actions
:
Exercise: Endurance
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Neuroprotective Agents
[+]
Epigallocatechin gallate exerts protective effects against myocardial ischemia/reperfusion injury.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2016 Jul ;38(1):328-36. Epub 2016 May 31. PMID:
27246989
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
[+]
Epigallocatechin gallate prevents mitochondrial impairment and cell apoptosis.
Jan 29, 2019
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2019 Jan 30 ;61:152845. Epub 2019 Jan 30. PMID:
31029907
Article Published Date
: Jan 29, 2019
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Myocardial Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
MicroRNA modulator
[+]
Ergosterol attenuates cigarette smoke extract-induced chronic obstructive pulmonary disease.
Jul 14, 2019
Click here to read the entire abstract
Pubmed Data
: Clin Sci (Lond). 2019 Jul 15 ;133(13):1523-1536. Epub 2019 Jul 15. PMID:
31270147
Article Published Date
: Jul 14, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cordyceps sinensis
Diseases
:
Chronic Obstructive Pulmonary Disease
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Interleukin-6 Downregulation
,
Malondialdehyde Down-regulation
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Eriobotrya japonica leaf extract potentially provides cardio-protective effects against hypertension-induced cardiac apoptosis and fibrosis.
May 30, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Mol Sci. 2018 May 31 ;19(6). Epub 2018 May 31. PMID:
29857545
Article Published Date
: May 30, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Loquat
Diseases
:
Hypertension
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Fibrotic
,
Cardioprotective
[+]
Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation.
Feb 04, 2016
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2016 Feb 5 ;772:124-30. Epub 2015 Dec 23. PMID:
26723515
Article Published Date
: Feb 04, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Eriodictyol
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Antioxidants
,
Chemoprotective Agents
,
NF-kappaB Inhibitor
[+]
Eriodictyol might be a promising novel therapeutic agent for Alzheimer's disease.
Jun 30, 2015
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2015 Jul ;40(7):1463-71. Epub 2015 May 21. PMID:
25994859
Article P
