Anti-Fibrotic

Name	AC	CK
Curcumin	24	46
Tanshinone IIA	15	44
Puerarin	15	31
Vitamin D	6	30
Astragaloside	15	24
Ginsenosides	14	23
Astaxanthin	10	21
Lycopene	3	21
Coenzyme Q10	5	17
Resveratrol	10	16
Flavonoids	8	14
Paeoniflorin	8	13
Piperine	3	13
Apigenin	3	12
Asiatic Acid	6	12
Berberine	7	12
Crocin	6	12
Ginseng (Korean)	2	12
Selenium	2	12
Emodin	7	11
Mangiferin	6	11
Thymoquinone	6	11
Flaxseed	1	10
Nigella sativa (aka Black Seed)	6	10
Quercetin	4	10
Silymarin	1	10
Naringenin	5	9
Pterostilbene	5	9
Fisetin	4	8
Fucoidan	4	8
Myricetin	4	8
Paeonol	4	8
EGCG (Epigallocatechin gallate)	5	7
Ferulic acid	3	7
Gallic Acid	4	7
Hydrogen Water	3	7
Safflower	4	7
Tannic Acid	2	7
Ursolic Acid	4	7
Betulinic acid	4	6
Curcumol	5	6
DHA (Docosahexaenoic Acid)	3	6
Honokiol	4	6
Licorice	3	6
Luteolin	3	6
NAC (N-acetyl-L-cysteine)	4	6
Salvia miltiorrhiza	4	6
Shikonin	3	6
Silibinin	3	6
Vitamin C	3	6
Baicalein	1	5
Beta-Elemene	3	5
Chrysin	3	5
Cinnamaldehyde	1	5
Gotu Kola	3	5
Kaempferol	3	5
Piperlongumine	3	5
Prunella vulgaris	1	5
Schisandra	1	5
Triphala	1	5
Arctigenin	3	4
Ashwagandha	2	4
Astragalus	2	4
Babchi	2	4
Blueberry	2	4
Cannabinoids	3	4
Celastrol	2	4
Chlorogenic Acid	2	4
Diosgenin	3	4
Diosmin	2	4
Fermented Foods and Beverages	2	4
Fucoxanthin	3	4
Grape Seed Extract	2	4
L-Carnitine	2	4
Lactobacillus rhamnosus GG	2	4
Medicinal Mushrooms	2	4
Melatonin	3	4
Modified Citrus Pectin	2	4
Oridonin	2	4
Palmitoylethanolamide	2	4
Pomegranate	3	4
Probiotics	2	4
Red Sage	2	4
Rosmarinic acid	2	4
Spirulina	2	4
Tetrahydrocurcumin	2	4
Vitamin E	2	4
Yoghurt	2	4
Artesunate	2	3
Bee Venom	2	3
Carnosic Acid	2	3
Chamomile	2	3
Citrus naringin	2	3
Evodiamine	2	3
Genistein	2	3
Indole-3-Carbinol	2	3
Isoliquiritigenin	2	3
Liquiritigenin	2	3
Milk Thistle	2	3
Peony	2	3
Rose	2	3
Rosemaric Acid	2	3
Sulforaphane	3	3
Wogonin	2	3
2-Methoxyestradiol	1	2
Allicin	1	2
Aloe Vera	1	2
Alpha-Lipoic Acid	1	2
Amygdalin	1	2
Bacopa	1	2
Bamboo	1	2
Berries: All	1	2
Beta Sitosterol	1	2
Betanin	1	2
Biochanin A	1	2
Bisdemethoxycurcumin	1	2
Caffeic acid phenethyl ester	1	2
Camel Milk	1	2
Cannabis	1	2
Carvacrol	1	2
Chlorella (Algae)	1	2
Cinnamon	1	2
Corn Silk	1	2
Cranberry	1	2
Cucurbitacin B	1	2
Cucurbitacin E	1	2
Dandelion	1	2
Fenugreek	1	2
Formononetin	1	2
Frankincense	1	2
Garlic: Aged	1	2
Geraniol	1	2
Ginger	1	2
Ginseng	1	2
Green Tea	1	2
Gynostemma	2	2
Helenalin	1	2
Hesperidin	1	2
Hibiscus sabdariffa	1	2
Honey	1	2
Hops	1	2
Isothiocyanates	1	2
Kefir	1	2
Kombucha Tea	1	2
Krill	1	2
Lactoferrin	1	2
Lemon	1	2
Lemon Balm	1	2
Ligustrazine	1	2
Loquat	1	2
Loquat Seeds	1	2
Lotus	1	2
Magnolol	1	2
Myrtle	1	2
Noni	1	2
Oleanolic acid	1	2
Oligonol	1	2
Omega-3 Fatty Acids	1	2
Orange	1	2
Panax Notoginseng	1	2
Parthenolide	1	2
Perilla	1	2
Piceatannol	1	2
Polyunsaturated Fatty Acids (PUFAs)	1	2
Pomegranate Seed	1	2
Prickly Pear Cactus	1	2
Protandim	1	2
Radish	1	2
Rhubarb	1	2
Rosemary	1	2
Rutin	1	2
Sage	1	2
Salacia oblonga	1	2
Sea buckthorn	1	2
Spermidine	1	2
Strawberry	1	2
Taurine	1	2
Turmeric	1	2
Vanillin	1	2
Vitamin E: Gamma-tocotrienol	1	2
Walnut	1	2
Xanthohumol	1	2
Zataria multiflora	1	2
neohesperidin	1	2
Amygdalin (laetrile)	1	1
Bitter Melon	1	1
Butyrate	1	1
Carnosol	1	1
Celery seed	1	1
Coffee	1	1
Cordyceps sinensis	1	1
D-Limonene	1	1
Dong Quai	1	1
Ellagic Acid	1	1
Gingerol	1	1
Mangosteen	1	1
Moringa oleifera	1	1
Nicotinamide adenine dinucleotide (NADH)	1	1
Okra	1	1
Phellinus Linteus	1	1
Procyanidin B2	1	1
Stilbenes	1	1
Zhu Ling Mushroom	1	1
acetyl-11-keto-beta-boswellic acid	1	1

[+]

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Pubmed Data : Int J Food Sci Nutr. 2016 Jun ;67(4):461-9. Epub 2016 Mar 17. PMID: 26983396

Article Published Date : May 31, 2016

Study Type : Human Study

Additional Links

Substances : Flaxseed

Diseases : Insulin Resistance, Liver Fibrosis, Liver Steatosis, Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Integrative Medicine, Lifestyle Changes: Positive

Pharmacological Actions : Anti-Fibrotic, Enzyme Inhibitors, Hepatoprotective

Additional Keywords : Significant Treatment Outcome

[+]

Galectin-3 inhibition with modified citrus pectin in hypertension. Dec 31, 2020

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Treatment with lycopene led to improvement in the symptoms of oral submucous fibrosis in the present study.Jul 10, 2020

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Pubmed Data : J Oral Pathol Med. 2020 Jul 11. Epub 2020 Jul 11. PMID: 32652683

Article Published Date : Jul 10, 2020

Study Type : Human Study

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Substances : Lycopene

Diseases : Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Zinc administration and improved serum markers of hepatic fibrosis in patients with autoimmune hepatitis.Jun 01, 2021

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2017 Mar 21 ;97(11):869-873. PMID: 28355745

Article Published Date : Mar 20, 2017

Study Type : Human In Vitro

Additional Links

Substances : Cinnamaldehyde

Diseases : Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic

[+]

Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways.Feb 01, 2019

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Pubmed Data : Chem Biol Interact. 2019 Feb 1 ;299:131-139. Epub 2018 Dec 11. PMID: 30543783

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Pubmed Data : Med Gas Res. 2016 Jul-Sep;6(3):177-179. Epub 2016 Oct 14. PMID: 27867488

Article Published Date : Jun 30, 2016

Study Type : Human: Case Report

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Substances : Hydrogen Water

Diseases : Graft vs Host Disease

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants

[+]

Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.Oct 09, 2019

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Pubmed Data : Life Sci. 2021 Jan 15 ;265:118835. Epub 2020 Nov 28. PMID: 33253723

Article Published Date : Jan 14, 2021

Study Type : Animal Study

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Substances : Amygdalin

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Fibrotic, anti-inflammatory, Antioxidants, Renoprotective

[+]

Amygdalin improves microcirculatory disturbance and attenuates pancreatic fibrosis.Nov 08, 2017

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Pubmed Data : J Food Biochem. 2021 Jun 22:e13819. Epub 2021 Jun 22. PMID: 34159624

Article Published Date : Jun 21, 2021

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Pubmed Data : J Biochem Mol Toxicol. 2020 Mar 15:e22492. Epub 2020 Mar 15. PMID: 32173980

Article Published Date : Mar 14, 2020

Study Type : Animal Study

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Substances : Resveratrol

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Antioxidants, Cardioprotective, Chemoprotective Agents

[+]

Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

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Pubmed Data : World J Gastroenterol. 2006 Nov 14 ;12(42):6835-41. PMID: 17106933

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Pubmed Data : SAGE Open Med. 2019 ;7:2050312119828260. Epub 2019 Feb 4. PMID: 30783524

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Fibrosis, Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

[+]

Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

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Pubmed Data : Biomed Pharmacother. 2017 May ;89:1297-1309. Epub 2017 Mar 17. PMID: 28320097

Article Published Date : Apr 30, 2017

Study Type : Animal Study

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Substances : Gotu Kola

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Inflammation

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

[+]

Astragaloside IV attenuates renal fibrosis through repressing epithelial-to-mesenchymal transition.Dec 31, 2018

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Pubmed Data : J Ethnopharmacol. 2019 Nov 15:112404. Epub 2019 Nov 15. PMID: 31739105

Article Published Date : Nov 14, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Astragaloside

Diseases : Cardiovascular Diseases, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective, MicroRNA modulator

[+]

Astragaloside IV inhibits excessive mesangial cell proliferation and renal fibrosis caused by diabetic nephropathy.Sep 30, 2019

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Pubmed Data : Phytomedicine. 2017 Jul 1 ;30:10-17. Epub 2017 Apr 19. PMID: 28545665

Article Published Date : Jun 30, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Astragaloside

Diseases : Hypoxia, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

[+]

Astragalus saponins and glycyrrhizic acid synergistically alleviated hepatic fibrosis.Jun 05, 2016

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Pubmed Data : Front Immunol. 2019 ;10:1257. Epub 2019 Jun 11. PMID: 31244833

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Betulinic acid

Diseases : Chagas Disease, Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Biochanin-A ameliorates pulmonary fibrosis.Jul 31, 2020

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Pubmed Data : Zhonghua Gan Zang Bing Za Zhi. 2018 Aug 20 ;26(8):590-595. PMID: 30317790

Article Published Date : Aug 19, 2018

Study Type : Animal Study

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Substances : Blueberry

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

[+]

Blueberry attenuated liver fibrosis, protected intestinal epithelial barrier, and maintained the homeostasis of the gut microbiota.Dec 31, 2018

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Pubmed Data : Can J Gastroenterol Hepatol. 2019 ;2019:5236149. Epub 2019 Nov 22. PMID: 31886154

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Blueberry

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Gastrointestinal Agents, Gastroprotective, Hepatoprotective

Additional Keywords : Gut-liver axis

[+]

Both rosemary extracts administrated alone or in combination alleviated synergistically lung fibrosis.Oct 15, 2020

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Pubmed Data : Nutr Cancer. 2020 Oct 16:1-12. Epub 2020 Oct 16. PMID: 33059466

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Pubmed Data : Can J Physiol Pharmacol. 2016 May 30:1-10. Epub 2016 May 30. PMID: 27455095

Article Published Date : May 29, 2016

Study Type : Animal Study

Additional Links

Substances : Camel Milk , Honey

Diseases : Chemically-Induced Liver Damage, Liver Cirrhosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis.Jan 10, 2020

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Pubmed Data : Phytomedicine. 2020 Feb ;67:153160. Epub 2019 Dec 26. PMID: 31901889

Article Published Date : Jan 31, 2020

Study Type : Animal Study

Additional Links

Substances : Celastrol

Diseases : Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Chamomile hydroalcoholic extract may be able to diminish the toxic effects of bleomycin on the lung tissues.Sep 30, 2018

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Pubmed Data : J Zhejiang Univ Sci B. 2011 Dec ;12(12):1024-33. PMID: 22135152

[+]

Danshensu alleviates bleomycin-induced pulmonary fibrosis.Nov 30, 2021

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Pubmed Data : Cell Physiol Biochem. 2016 ;40(6):1422-1432. Epub 2016 Dec 20. PMID: 27997902

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Flavonoids

Diseases : Liver Cirrhosis, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

[+]

Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.Dec 31, 2017

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Fermented rice bran supplementation prevents the development of intestinal fibrosis due to DSS-induced inflammation.May 29, 2021

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Pubmed Data : Nutrients. 2021 May 30 ;13(6). Epub 2021 May 30. PMID: 34070845

Article Published Date : May 29, 2021

Study Type : Animal Study

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Substances : Fermented Foods and Beverages, Rice Bran

Diseases : Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Gastroprotective

[+]

Ferulic acid combined with astragaloside IV reduced the degree of pulmonary fibrosis.Dec 31, 2020

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Pubmed Data : Food Funct. 2020 May 1 ;11(5):4615-4624. Epub 2020 May 13. PMID: 32400831

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Pubmed Data : Eur J Pharmacol. 2015 Sep 5 ;762:102-11. Epub 2015 May 22. PMID: 26004525

Article Published Date : Sep 04, 2015

Study Type : Animal Study

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Substances : Geraniol

Diseases : Atherosclerosis, Fibrosis, Oxidative Stress

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Ginger extract protects the heart against inflammation and fibrosis in diabetes.Sep 01, 2020

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Pubmed Data : Can J Diabetes. 2020 Sep 2. Epub 2020 Sep 2. PMID: 33162372

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Pubmed Data : J Ginseng Res. 2019 Oct ;43(4):606-617. Epub 2018 Aug 10. PMID: 31695567

Article Published Date : Sep 30, 2019

Study Type : Animal Study

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Substances : Ginseng, Ginsenosides

Diseases : Liver Failure: Acute, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation.Dec 26, 2019

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Pubmed Data : J Photochem Photobiol B. 2020 Jan ;203:111731. Epub 2019 Dec 4. PMID: 31935633

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Diseases : Lung Inflammation, Pulmonary Fibrosis

Therapeutic Actions : Laser Treatment: Low-Level

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

[+]

Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2018

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Pubmed Data : Am J Transl Res. 2019 ;11(4):2590-2602. Epub 2019 Apr 15. PMID: 31105865

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Fucoidan

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

[+]

Lung injury induced by bisphenol A is ameliorated by selenium supplementation.Feb 11, 2017

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Pubmed Data : Pathophysiology. 2017 Feb 12. Epub 2017 Feb 12. PMID: 28285737

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Pubmed Data : J Agric Food Chem. 2010 Nov 24 ;58(22):11653-61. Epub 2010 Oct 19. PMID: 20958047

Article Published Date : Nov 23, 2010

Study Type : Animal Study, In Vitro Study

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Substances : Luteolin

Diseases : Fibrosis

Pharmacological Actions : Anti-Fibrotic, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Lycopene corrects metabolic syndrome and liver injury induced by high fat diet.Jul 05, 2021

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Pubmed Data : Biomed Pharmacother. 2021 Jul 6 ;141:111831. Epub 2021 Jul 6. PMID: 34237596

Article Published Date : Jul 05, 2021

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : High Fat Diet, Obesity

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Anti-Obesity Agents

[+]

Magnolol attenuates concanavalin A-induced hepatic fibrosis.May 31, 2017

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Pubmed Data : J Chin Med Assoc. 2017 Apr ;80(4):212-221. Epub 2017 Mar 6. PMID: 28268174

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Fermented Foods and Beverages, Noni

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

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Pubmed Data : Oncotarget. 2016 Sep 20 ;7(38):61703-61715. PMID: 27533252

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Pubmed Data : Mol Immunol. 2019 08 ;112:247-255. Epub 2019 Jun 12. PMID: 31202101

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Neem

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor

[+]

Nrf2 Is a key regulator on puerarin preventing cardiac fibrosis.Dec 31, 2017

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2019 Nov ;23(22):10151-10160. PMID: 31799687

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Pubmed Data : Exp Parasitol. 2019 Feb ;197:85-92. Epub 2018 Nov 8. PMID: 30414842

Article Published Date : Jan 31, 2019

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Liver Disease, Schistosomiasis

Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic, Vascular Endothelial Growth Factor Inhibitors

[+]

Paeonol delays the progression of diabetic renal fibrosis.Dec 31, 2017

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Pubmed Data : Antioxidants (Basel). 2021 Feb 28 ;10(3). Epub 2021 Feb 28. PMID: 33671028

Article Published Date : Feb 27, 2021

Study Type : Animal Study

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Substances : Oligonol

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Protective effect of selenium-enriched green tea on carbon tetrachloride-induced liver fibrosis.Jul 11, 2021

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Pubmed Data : Biol Trace Elem Res. 2021 Jul 12. Epub 2021 Jul 12. PMID: 34251588

Article Published Date : Jul 11, 2021

Study Type : Animal Study

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Substances : Green Tea, Selenium

Diseases : Chemically-Induced Liver Damage, Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

[+]

Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis.Dec 31, 2011

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 Jun ;43(12):2618-2623. PMID: 29950085

Article Published Date : May 31, 2018

Study Type : Animal Study

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Substances : Puerarin

Diseases : Fibrosis, Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Anti-Fibrotic

[+]

Puerarin may provide a new adjuvant for antifibrotic treatment strategies for patients with heart disease.Dec 31, 2016

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Pubmed Data : PPAR Res. 2017 ;2017:2647129. Epub 2017 May 30. PMID: 28638404

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Substances : Puerarin

Diseases : Heart Disease, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

[+]

Quercetin reduced the population of macrophages and myofibroblasts and the scar formation in cutaneous wound healing. Jul 16, 2018

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Pubmed Data : Pharmacology. 2018 Jul 17 ;102(3-4):142-153. Epub 2018 Jul 17. PMID: 30016781

Article Published Date : Jul 16, 2018

Study Type : Animal Study

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Substances : Quercetin

Diseases : Scars, Wound Healing

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

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View the Evidence: 538 Abstracts with Anti-Fibrotic Research

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Efficacy of lycopene in the treatment of oral submucous fibrosis.Jan 11, 2020

Evaluation of astragaloside IV in hepatic fibrosis: A meta-analysis. Apr 01, 2021

Tanshinone IIA can effectively improve liver fibrosis and liver function.Dec 31, 2018

This study determines the positive efficacy of vitamin D supplementation for chronic liver disease.Apr 30, 2020

Apigenin could be an attractive therapeutic potential for the treatment of renal fibrosis.Mar 20, 2020

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.May 31, 2016

Galectin-3 inhibition with modified citrus pectin in hypertension. Dec 31, 2020

Korean Red Ginseng could be used as a complementary therapy for chronic hepatitis B.Nov 30, 2016

NAC could ameliorate COPD-induced pulmonary fibrosis by promoting immune response.Jan 02, 2021

Pycnogenol®-Centellicum® supplementation improves lung fibrosis and Post-Covid-19 lung healing.Jun 27, 2021

Silymarin may reduce liver fibrosis.Apr 14, 2017

There was less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10.Dec 07, 2017

Treatment with lycopene led to improvement in the symptoms of oral submucous fibrosis in the present study.Jul 10, 2020

Zinc administration and improved serum markers of hepatic fibrosis in patients with autoimmune hepatitis.Jun 01, 2021

Astaxanthin may be useful as a preventive/therapeutic agent for cardiac dysfunction and myocardial fibrosis.Mar 11, 2017

Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21.Jan 01, 2018

Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation.Jan 01, 2019

Cinnamaldehyde may be able to slow down the progression of cardiac fibrosis.Mar 20, 2017

Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways.Feb 01, 2019

Phlorotannins should be considered a promising candidate for use in the prevention of vocal fold fibrosis.Jan 11, 2020

Photobiomodulation therapy enhances the anti-fibrotic activity of adipose-derived mesenchymal stem cells.Feb 01, 2019

Prunella vulgaris attenuates diabetic renal injury.Mar 29, 2017

Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells.Nov 04, 2020

Schisanhenol may be a potential anti-liver fibrosis drug.Mar 19, 2020

The antifibrotic effect of quercetin can be enhanced by adding methyl group on functionally important position.Dec 01, 2019

Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease.Jun 30, 2016

Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.Oct 09, 2019

Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β.Jun 10, 2020

Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation.Nov 29, 2020

A multi-herbal product called Protandim prevents fibrosis and capillary loss and preserves right ventricular function in rats.Nov 17, 2009

A potential anti-liver fibrosis mechanism of curcumol may be associated with the inhibition of NLRP3 inflammasomes.Jul 27, 2021

A. vera supplementation protects against development of cardiac inflammation, fibrosis, and oxidative stress in isoprenaline-administered rats.Aug 31, 2019

Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.Mar 01, 2017

Active components from Sea Buckthorn regulate hepatic stellate cell activation and liver fibrogenesis.Nov 20, 2018

Active vitamin D impedes the progression of non-alcoholic fatty liver disease.Dec 02, 2019

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.Nov 30, 2017

Allicin has the potential to help in the treatment of diabetic nephropathy.Nov 14, 2020

Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation.Jun 05, 2018

Ameliorating effects of white mulberry on iron-overload-induced oxidative stress and liver fibrosis.Aug 27, 2021

Amygdalin alleviates renal injury by suppressing inflammation, oxidative stress and fibrosis in streptozotocin-induced diabetes.Jan 14, 2021

Amygdalin improves microcirculatory disturbance and attenuates pancreatic fibrosis.Nov 08, 2017

Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells.Dec 31, 2020

Andrographolide prevents high glucose-induced renal tubular cell damage.Jul 08, 2021

ANG II-AT1 receptor pathway is involved in the anti-fibrotic effect of beta-elemene.Mar 31, 2009

Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-β/AKT/mTOR signaling pathway.Mar 12, 2020

Anti-fibrotic actions of roselle extract in rat model of myocardial infarction.Aug 19, 2018

Anti-fibrotic effects of curcumin and some of its analogues in the heart.Sep 10, 2019

Anti-inflammatory activity of ginger modulates macrophage activation against the inflammatory pathway of monosodium glutamat.Jun 21, 2021

Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats.May 31, 2014

Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Apr 30, 2018

Antifibrotic effects of gallic acid on hepatic stellate cells.Dec 31, 2018

Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis.Aug 20, 2018

Antioxidant, anti-inflammatory and anti-fibrotic effects of Boswellia serrate gum resin in CCl4-induced hepatotoxicityJan 31, 2020

Antioxidant, antiapoptotic, and antifibrotic effects of the combination of liposomal resveratrol and carvedilol against doxorubicin-induced cardiomyopathy.Mar 14, 2020

Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

Apigenin ameliorates hyperuricemic nephropathy.May 22, 2021

Arctigenin could protect the kidney from unilateral ureteral obstruction induced injury and fibrogenesis.Jun 30, 2017

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway.Dec 31, 2018

Ascorbic acid attenuated the inflammatory response and fibrosis in the lungs of rats treated with lipopolysaccharide.Dec 31, 2018

Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Asiatic acid inhibits lliver fibrosis.Dec 31, 2011

Asiatic acid might be an effective candidate for pulmonary fibrosis and inflammation treatment.Apr 30, 2017

Asiaticoside attenuates bleomycin-induced pulmonary fibrosis.Jun 29, 2020

Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.Feb 18, 2019

Astaxanthin and vitamin E effectively improved hepatic gene expression.Mar 07, 2017

Astaxanthin given in the post injury period significantly decreases fibrosis.Nov 10, 2019

Astaxanthin had a significant protective effect on liver fibrosis by suppressing multiple pro-fibrogenic factors.Dec 31, 2013

Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue.Mar 01, 2016

Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment.Jun 02, 2019

Astragaloside inhibits hepatic fibrosis by modulation of TGF-β1/Smad signalling pathway.Dec 31, 2017

Anti-Fibrotic

View the Evidence:
538 Abstracts with Anti-Fibrotic Research