Anti-Fibrotic

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204 Substances Researched for Anti-Fibrotic
NameACCKFocus
Curcumin2446Locked
Tanshinone IIA1544Locked
Puerarin1531Locked
Vitamin D630Locked
Astragaloside1524Locked
Ginsenosides1423Locked
Astaxanthin1021Locked
Lycopene321Locked
Coenzyme Q10517Locked
Resveratrol1016Locked
Flavonoids814Locked
Paeoniflorin813Locked
Piperine313Locked
Apigenin312Locked
Asiatic Acid612Locked
Berberine712Locked
Crocin612Locked
Ginseng (Korean)212Locked
Selenium212Locked
Emodin711Locked
Mangiferin611Locked
Thymoquinone611Locked
Flaxseed110Locked
Nigella sativa (aka Black Seed)610Locked
Quercetin410Locked
Silymarin110Locked
Naringenin 59Locked
Pterostilbene59Locked
Fisetin48Locked
Fucoidan48Locked
Myricetin48Locked
Paeonol48Locked
EGCG (Epigallocatechin gallate)57Locked
Ferulic acid37Locked
Gallic Acid47Locked
Hydrogen Water37Locked
Safflower47Locked
Tannic Acid27Locked
Ursolic Acid47Locked
Betulinic acid46Locked
Curcumol56Locked
DHA (Docosahexaenoic Acid)36Locked
Honokiol46Locked
Licorice36Locked
Luteolin36Locked
NAC (N-acetyl-L-cysteine)46Locked
Salvia miltiorrhiza46Locked
Shikonin36Locked
Silibinin36Locked
Vitamin C36Locked
Baicalein15Locked
Beta-Elemene35Locked
Chrysin35Locked
Cinnamaldehyde15Locked
Gotu Kola35Locked
Kaempferol35Locked
Piperlongumine 35Locked
Prunella vulgaris15Locked
Schisandra15Locked
Triphala15Locked
Arctigenin34Locked
Ashwagandha24Locked
Astragalus24Locked
Babchi24Locked
Blueberry24Locked
Cannabinoids 34Locked
Celastrol24Locked
Chlorogenic Acid24Locked
Diosgenin34Locked
Diosmin 24Locked
Fermented Foods and Beverages24Locked
Fucoxanthin 34Locked
Grape Seed Extract24Locked
L-Carnitine24Locked
Lactobacillus rhamnosus GG24Locked
Medicinal Mushrooms24Locked
Melatonin34Locked
Modified Citrus Pectin 24Locked
Oridonin24Locked
Palmitoylethanolamide 24Locked
Pomegranate34Locked
Probiotics24Locked
Red Sage24Locked
Rosmarinic acid24Locked
Spirulina24Locked
Tetrahydrocurcumin24Locked
Vitamin E24Locked
Yoghurt24Locked
Artesunate23Locked
Bee Venom23Locked
Carnosic Acid23Locked
Chamomile23Locked
Citrus naringin23Locked
Evodiamine23Locked
Genistein23Locked
Indole-3-Carbinol23Locked
Isoliquiritigenin23Locked
Liquiritigenin23Locked
Milk Thistle23Locked
Peony23Locked
Rose 23Locked
Rosemaric Acid23Locked
Sulforaphane33Locked
Wogonin23Locked
2-Methoxyestradiol12Locked
Allicin12Locked
Aloe Vera12Locked
Alpha-Lipoic Acid12Locked
Amygdalin12Locked
Bacopa12Locked
Bamboo12Locked
Berries: All12Locked
Beta Sitosterol12Locked
Betanin12Locked
Biochanin A12Locked
Bisdemethoxycurcumin12Locked
Caffeic acid phenethyl ester12Locked
Camel Milk 12Locked
Cannabis12Locked
Carvacrol12Locked
Chlorella (Algae)12Locked
Cinnamon12Locked
Corn Silk12Locked
Cranberry12Locked
Cucurbitacin B 12Locked
Cucurbitacin E 12Locked
Dandelion 12Locked
Fenugreek12Locked
Formononetin12Locked
Frankincense12Locked
Garlic: Aged12Locked
Geraniol 12Locked
Ginger12Locked
Ginseng12Locked
Green Tea12Locked
Gynostemma22Locked
Helenalin12Locked
Hesperidin12Locked
Hibiscus sabdariffa 12Locked
Honey12Locked
Hops12Locked
Isothiocyanates12Locked
Kefir12Locked
Kombucha Tea12Locked
Krill12Locked
Lactoferrin12Locked
Lemon12Locked
Lemon Balm12Locked
Ligustrazine12Locked
Loquat12Locked
Loquat Seeds12Locked
Lotus 12Locked
Magnolol12Locked
Myrtle12Locked
Noni12Locked
Oleanolic acid12Locked
Oligonol12Locked
Omega-3 Fatty Acids12Locked
Orange12Locked
Panax Notoginseng12Locked
Parthenolide12Locked
Perilla 12Locked
Piceatannol 12Locked
Polyunsaturated Fatty Acids (PUFAs)12Locked
Pomegranate Seed12Locked
Prickly Pear Cactus12Locked
Protandim12Locked
Radish12Locked
Rhubarb12Locked
Rosemary12Locked
Rutin12Locked
Sage12Locked
Salacia oblonga12Locked
Sea buckthorn12Locked
Spermidine 12Locked
Strawberry12Locked
Taurine12Locked
Turmeric12Locked
Vanillin12Locked
Vitamin E: Gamma-tocotrienol12Locked
Walnut12Locked
Xanthohumol12Locked
Zataria multiflora12Locked
neohesperidin12Locked
Amygdalin (laetrile)11Locked
Bitter Melon11Locked
Butyrate11Locked
Carnosol11Locked
Celery seed11Locked
Coffee11Locked
Cordyceps sinensis11Locked
D-Limonene11Locked
Dong Quai11Locked
Ellagic Acid11Locked
Gingerol 11Locked
Mangosteen11Locked
Moringa oleifera11Locked
Nicotinamide adenine dinucleotide (NADH) 11Locked
Okra11Locked
Phellinus Linteus11Locked
Procyanidin B2 11Locked
Stilbenes11Locked
Zhu Ling Mushroom 11Locked
acetyl-11-keto-beta-boswellic acid11Locked

View the Evidence:
574 Abstracts with Anti-Fibrotic Research

[+]

Efficacy of lycopene in the treatment of oral submucous fibrosis.Jan 11, 2020

Pubmed Data : J Evid Based Dent Pract. 2020 12 ;20(4):101471. Epub 2020 Jul 6. PMID: 33303091
Article Published Date : Jan 11, 2020
Study Type : Meta Analysis
Additional Links
Substances : Lycopene
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Evaluation of astragaloside IV in hepatic fibrosis: A meta-analysis. Apr 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicine (Baltimore). 2021 Apr 2 ;100(13):e25105. PMID: 33787592
Article Published Date : Apr 01, 2021
Study Type : Meta Analysis
Additional Links
Substances : Astragaloside
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Tanshinone IIA can effectively improve liver fibrosis and liver function.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:7514046. Epub 2019 Dec 13. PMID: 31915451
Article Published Date : Dec 31, 2018
Study Type : Meta Analysis
Additional Links
Substances : Tanshinone IIA
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective
[+]

This study determines the positive efficacy of vitamin D supplementation for chronic liver disease.Apr 30, 2020

Pubmed Data : Medicine (Baltimore). 2020 May ;99(19):e20296. PMID: 32384521
Article Published Date : Apr 30, 2020
Study Type : Meta Analysis, Review
Additional Links
Substances : Vitamin D
Diseases : Liver Disease, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Apigenin could be an attractive therapeutic potential for the treatment of renal fibrosis.Mar 20, 2020

Pubmed Data : Curr Pharm Biotechnol. 2020 Mar 20. Epub 2020 Mar 20. PMID: 32196447
Article Published Date : Mar 20, 2020
Study Type : Human Study
Additional Links
Substances : Apigenin
Diseases : Renal Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Association between serum vitamin D level and immune imbalance in advanced schistosomiasis patients with liver fibrosis.Feb 03, 2021

Pubmed Data : Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2021 Feb 4 ;33(1):22-27. PMID: 33660470
Article Published Date : Feb 03, 2021
Study Type : Human Study
Additional Links
Substances : Vitamin D
Diseases : Liver Cirrhosis, Liver Fibrosis, Schistosomiasis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Immunomodulatory
[+]

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Contemp Clin Dent. 2019 Jul-Sep;10(3):531-541. PMID: 32308333
Article Published Date : Jun 30, 2019
Study Type : Human Study
Additional Links
Substances : Curcumin, Lycopene, Piperine
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.May 31, 2016

Pubmed Data : Int J Food Sci Nutr. 2016 Jun ;67(4):461-9. Epub 2016 Mar 17. PMID: 26983396
Article Published Date : May 31, 2016
Study Type : Human Study
Additional Links
Substances : Flaxseed
Diseases : Insulin Resistance, Liver Fibrosis, Liver Steatosis, Nonalcoholic fatty liver disease (NAFLD)
Therapeutic Actions : Integrative Medicine, Lifestyle Changes: Positive
Pharmacological Actions : Anti-Fibrotic, Enzyme Inhibitors, Hepatoprotective
Additional Keywords : Significant Treatment Outcome
[+]

Galectin-3 inhibition with modified citrus pectin in hypertension. Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JACC Basic Transl Sci. 2021 Jan ;6(1):12-21. Epub 2021 Jan 6. PMID: 33532663
Article Published Date : Dec 31, 2020
Study Type : Human Study
Additional Links
Substances : Modified Citrus Pectin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Korean Red Ginseng could be used as a complementary therapy for chronic hepatitis B.Nov 30, 2016

Pubmed Data : J Altern Complement Med. 2016 Dec ;22(12):964-969. Epub 2016 Sep 7. PMID: 27603149
Article Published Date : Nov 30, 2016
Study Type : Human Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Hepatitis B
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

NAC could ameliorate COPD-induced pulmonary fibrosis by promoting immune response.Jan 02, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med. 2021 09 3 ;27(1):97. Epub 2021 Sep 3. PMID: 34479474
Article Published Date : Jan 02, 2021
Study Type : Human Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Chronic Obstructive Pulmonary Disease, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Immunomodulatory
[+]

Pycnogenol®-Centellicum® supplementation improves lung fibrosis and Post-Covid-19 lung healing.Jun 27, 2021

Pubmed Data : Minerva Med. 2021 Jun 28. Epub 2021 Jun 28. PMID: 34180638
Article Published Date : Jun 27, 2021
Study Type : Human Study
Additional Links
Substances : Pycnogenol (Pine Bark)
Diseases : Coronavirus Infection, Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Silymarin may reduce liver fibrosis.Apr 14, 2017

Pubmed Data : Clin Gastroenterol Hepatol. 2017 Apr 15. Epub 2017 Apr 15. PMID: 28419855
Article Published Date : Apr 14, 2017
Study Type : Human Study
Additional Links
Substances : Silymarin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic
[+]

There was less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10.Dec 07, 2017

Pubmed Data : Biofactors. 2017 Dec 8. Epub 2017 Dec 8. PMID: 29220105
Article Published Date : Dec 07, 2017
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10, Selenium
Diseases : Cardiac Mortality , Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
Additional Keywords : Risk Reduction
[+]

Treatment with lycopene led to improvement in the symptoms of oral submucous fibrosis in the present study.Jul 10, 2020

Pubmed Data : J Oral Pathol Med. 2020 Jul 11. Epub 2020 Jul 11. PMID: 32652683
Article Published Date : Jul 10, 2020
Study Type : Human Study
Additional Links
Substances : Lycopene
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Zinc administration and improved serum markers of hepatic fibrosis in patients with autoimmune hepatitis.Jun 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med. 2021 Jun 2 ;10(11). Epub 2021 Jun 2. PMID: 34199421
Article Published Date : Jun 01, 2021
Study Type : Human Study
Additional Links
Substances : Zinc
Diseases : Hepatitis: Autoimmune , Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Astaxanthin may be useful as a preventive/therapeutic agent for cardiac dysfunction and myocardial fibrosis.Mar 11, 2017

Pubmed Data : Biochim Biophys Acta. 2017 Mar 12. Epub 2017 Mar 12. PMID: 28300638
Article Published Date : Mar 11, 2017
Study Type : Human In Vitro
Additional Links
Substances : Astaxanthin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21.Jan 01, 2018

Pubmed Data : Toxicol Appl Pharmacol. 2018 11 1 ;358:35-42. Epub 2018 Sep 7. PMID: 30201452
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Baicalein
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation.Jan 01, 2019

Pubmed Data : Microvasc Res. 2019 01 ;121:14-23. Epub 2018 Sep 4. PMID: 30189210
Article Published Date : Jan 01, 2019
Study Type : Human In Vitro
Additional Links
Substances : Tannic Acid, Triphala
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Plant Extracts
[+]

Cinnamaldehyde may be able to slow down the progression of cardiac fibrosis.Mar 20, 2017

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2017 Mar 21 ;97(11):869-873. PMID: 28355745
Article Published Date : Mar 20, 2017
Study Type : Human In Vitro
Additional Links
Substances : Cinnamaldehyde
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways.Feb 01, 2019

Pubmed Data : Chem Biol Interact. 2019 Feb 1 ;299:131-139. Epub 2018 Dec 11. PMID: 30543783
Article Published Date : Feb 01, 2019
Study Type : Human In Vitro
Additional Links
Substances : Ferulic acid
Diseases : Fibrosis, Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic, Regenerative
Additional Keywords : Liver Regeneration
[+]

Phlorotannins should be considered a promising candidate for use in the prevention of vocal fold fibrosis.Jan 11, 2020

Pubmed Data : J Tissue Eng Regen Med. 2020 12 ;14(12):1918-1928. Epub 2020 Oct 20. PMID: 33049121
Article Published Date : Jan 11, 2020
Study Type : Human In Vitro
Additional Links
Substances : Phlorotannins
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Photobiomodulation therapy enhances the anti-fibrotic activity of adipose-derived mesenchymal stem cells.Feb 01, 2019

Pubmed Data : Lasers Med Sci. 2019 Feb ;34(1):1-10. Epub 2018 Oct 26. PMID: 30367294
Article Published Date : Feb 01, 2019
Study Type : Human In Vitro
Additional Links
Diseases : Fibrosis
Therapeutic Actions : Photodynamic therapy
Pharmacological Actions : Anti-Fibrotic, Regenerative
[+]

Prunella vulgaris attenuates diabetic renal injury.Mar 29, 2017

Pubmed Data : Am J Chin Med. 2017 Mar 30:1-21. Epub 2017 Mar 30. PMID: 28359196
Article Published Date : Mar 29, 2017
Study Type : Human In Vitro
Additional Links
Substances : Prunella vulgaris
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Renoprotective
[+]

Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells.Nov 04, 2020

Pubmed Data : Eur J Pharmacol. 2020 Nov 5 ;886:173472. Epub 2020 Aug 27. PMID: 32860809
Article Published Date : Nov 04, 2020
Study Type : Human In Vitro
Additional Links
Substances : Puerarin
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Schisanhenol may be a potential anti-liver fibrosis drug.Mar 19, 2020

Pubmed Data : J Nat Med. 2020 Mar 19. Epub 2020 Mar 19. PMID: 32193805
Article Published Date : Mar 19, 2020
Study Type : Human In Vitro
Additional Links
Substances : Schisandra
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

The antifibrotic effect of quercetin can be enhanced by adding methyl group on functionally important position.Dec 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Rep. 2019 Dec ;20:100678. Epub 2019 Aug 16. PMID: 31467991
Article Published Date : Dec 01, 2019
Study Type : Human In Vitro
Additional Links
Substances : Quercetin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Gas Res. 2016 Jul-Sep;6(3):177-179. Epub 2016 Oct 14. PMID: 27867488
Article Published Date : Jun 30, 2016
Study Type : Human: Case Report
Additional Links
Substances : Hydrogen Water
Diseases : Graft vs Host Disease
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
[+]

Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.Oct 09, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Orthop Surg Res. 2019 Oct 10 ;14(1):319. Epub 2019 Oct 10. PMID: 31601256
Article Published Date : Oct 09, 2019
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic
[+]

Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β.Jun 10, 2020

Pubmed Data : Biochem Pharmacol. 2020 Jun 11 ;178:114097. Epub 2020 Jun 11. PMID: 32535102
Article Published Date : Jun 10, 2020
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Heat Shock Protein Down-Regulation, Transforming growth factor beta (TGF-β) inhibitor
[+]

Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation.Nov 29, 2020

Pubmed Data : Phytomedicine. 2020 Nov 30 ;81:153426. Epub 2020 Nov 30. PMID: 33341026
Article Published Date : Nov 29, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cannabinoids , Cannabis
Diseases : Inflammation, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective
[+]

A multi-herbal product called Protandim prevents fibrosis and capillary loss and preserves right ventricular function in rats.Nov 17, 2009

Pubmed Data : Circulation. 2009 Nov 17;120(20):1951-60. Epub 2009 Nov 2. PMID: 19884466
Article Published Date : Nov 17, 2009
Study Type : Animal Study
Additional Links
Substances : Ashwagandha, Bacopa, Green Tea, Milk Thistle, Protandim, Turmeric
Diseases : Heart Failure, Hypertension, Hypertension: Pulmonary
Pharmacological Actions : Anti-Fibrotic, Vascular Endothelial Growth Factor A Inhibitor
[+]

A potential anti-liver fibrosis mechanism of curcumol may be associated with the inhibition of NLRP3 inflammasomes.Jul 27, 2021

Pubmed Data : Chin J Integr Med. 2021 Jul 28. Epub 2021 Jul 28. PMID: 34319504
Article Published Date : Jul 27, 2021
Study Type : Animal Study
Additional Links
Substances : Curcumol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

A. vera supplementation protects against development of cardiac inflammation, fibrosis, and oxidative stress in isoprenaline-administered rats.Aug 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Prev Nutr Food Sci. 2019 Sep ;24(3):254-264. Epub 2019 Sep 30. PMID: 31608250
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Aloe Vera
Diseases : Drug Toxicity: Isoprenaline
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.Mar 01, 2017

Pubmed Data : Biofactors. 2017 Mar ;43(2):272-282. Epub 2016 Nov 1. PMID: 27801960
Article Published Date : Mar 01, 2017
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Liver Regeneration
[+]

Activation of SIRT1 by resveratrol alleviates pressure overload-induced cardiac hypertrophy.Sep 07, 2021

Pubmed Data : Pharmacology. 2021 Sep 8:1-15. Epub 2021 Sep 8. PMID: 34518478
Article Published Date : Sep 07, 2021
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Active components from Sea Buckthorn regulate hepatic stellate cell activation and liver fibrogenesis.Nov 20, 2018

Pubmed Data : J Agric Food Chem. 2018 Nov 21 ;66(46):12257-12264. Epub 2018 Nov 13. PMID: 30398061
Article Published Date : Nov 20, 2018
Study Type : Animal Study
Additional Links
Substances : Sea buckthorn
Diseases : DNA damage, Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Active vitamin D impedes the progression of non-alcoholic fatty liver disease.Dec 02, 2019

Pubmed Data : Clin Res Hepatol Gastroenterol. 2019 Dec 3. Epub 2019 Dec 3. PMID: 31810868
Article Published Date : Dec 02, 2019
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
[+]

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Res Pharm Sci. 2017 Dec ;12(6):479-487. PMID: 29204176
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants
Additional Keywords : Anti-Fibrotic, Antioxidants, Kidney Fibrosis, thymoquinone
[+]

Allicin has the potential to help in the treatment of diabetic nephropathy.Nov 14, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Nov 15 ;9(11). Epub 2020 Nov 15. PMID: 33203103
Article Published Date : Nov 14, 2020
Study Type : Animal Study
Additional Links
Substances : Allicin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Renoprotective
[+]

Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation.Jun 05, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Vet Med Sci. 2018 Jun 6 ;80(6):893-897. Epub 2018 Apr 17. PMID: 29669958
Article Published Date : Jun 05, 2018
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Ameliorating effects of white mulberry on iron-overload-induced oxidative stress and liver fibrosis.Aug 27, 2021

Pubmed Data : Food Chem Toxicol. 2021 Aug 28:112520. Epub 2021 Aug 28. PMID: 34464637
Article Published Date : Aug 27, 2021
Study Type : Animal Study
Additional Links
Substances : White Mulberry
Diseases : Iron Overload, Liver Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Amygdalin alleviates renal injury by suppressing inflammation, oxidative stress and fibrosis in streptozotocin-induced diabetes.Jan 14, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life Sci. 2021 Jan 15 ;265:118835. Epub 2020 Nov 28. PMID: 33253723
Article Published Date : Jan 14, 2021
Study Type : Animal Study
Additional Links
Substances : Amygdalin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Fibrotic, anti-inflammatory, Antioxidants, Renoprotective
[+]

Amygdalin improves microcirculatory disturbance and attenuates pancreatic fibrosis.Nov 08, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Chin Med Assoc. 2017 Nov 9. Epub 2017 Nov 9. PMID: 29129515
Article Published Date : Nov 08, 2017
Study Type : Animal Study
Additional Links
Substances : Amygdalin
Diseases : Pancreatitis
Pharmacological Actions : Anti-Fibrotic, Pancreato Protective Agents
[+]

Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells.Dec 31, 2020

Pubmed Data : Int Immunopharmacol. 2021 Jan ;90:107151. Epub 2020 Dec 6. PMID: 33296784
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Amygdalin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Andrographolide prevents high glucose-induced renal tubular cell damage.Jul 08, 2021

Pubmed Data : Phytomedicine. 2021 Jul 9 ;91:153650. Epub 2021 Jul 9. PMID: 34332282
Article Published Date : Jul 08, 2021
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Renoprotective
[+]

ANG II-AT1 receptor pathway is involved in the anti-fibrotic effect of beta-elemene.Mar 31, 2009

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2009 Apr ;29(2):177-81. Epub 2009 Apr 28. PMID: 19399400
Article Published Date : Mar 31, 2009
Study Type : Animal Study
Additional Links
Substances : Beta-Elemene
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic
[+]

Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-β/AKT/mTOR signaling pathway.Mar 12, 2020

Pubmed Data : Life Sci. 2020 Mar 13:117552. Epub 2020 Mar 13. PMID: 32179074
Article Published Date : Mar 12, 2020
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Anti-fibrotic actions of roselle extract in rat model of myocardial infarction.Aug 19, 2018

Pubmed Data : Cardiovasc Toxicol. 2018 Aug 20. Epub 2018 Aug 20. PMID: 30128816
Article Published Date : Aug 19, 2018
Study Type : Animal Study
Additional Links
Substances : Hibiscus sabdariffa
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interleukin-10 downregulation, Interleukin-6 Downregulation
[+]

Anti-fibrotic effects of curcumin and some of its analogues in the heart.Sep 10, 2019

Pubmed Data : Heart Fail Rev. 2019 Sep 11. Epub 2019 Sep 11. PMID: 31512150
Article Published Date : Sep 10, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Anti-inflammatory activity of ginger modulates macrophage activation against the inflammatory pathway of monosodium glutamat.Jun 21, 2021

Pubmed Data : J Food Biochem. 2021 Jun 22:e13819. Epub 2021 Jun 22. PMID: 34159624
Article Published Date : Jun 21, 2021
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Inflammation, Rheumatoid Arthritis, Ulcerative Colitis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
Additional Keywords : Polysaccharides
Problem Substances : Monosodium Glutamate (MSG)
[+]

Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats.May 31, 2014

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2014 Jun ;387(6):559-67. Epub 2014 Mar 14. PMID: 24627177
Article Published Date : May 31, 2014
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2018 May ;25(4):747-754. Epub 2016 Oct 13. PMID: 29740240
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antifibrotic effects of gallic acid on hepatic stellate cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2019 Jan ;9(1):45-53. Epub 2018 Apr 27. PMID: 30671365
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gallic Acid
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis.Aug 20, 2018

Pubmed Data : Chem Biol Interact. 2018 Aug 21 ;294:91-100. Epub 2018 Aug 21. PMID: 30138605
Article Published Date : Aug 20, 2018
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Antioxidant properties of red raspberry extract alleviate hepatic fibrosis.Oct 05, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Oct 6 ;144:112284. Epub 2021 Oct 6. PMID: 34626932
Article Published Date : Oct 05, 2021
Study Type : Animal Study
Additional Links
Substances : Raspberry
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Antioxidants
[+]

Antioxidant, anti-inflammatory and anti-fibrotic effects of Boswellia serrate gum resin in CCl4-induced hepatotoxicityJan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2020 Feb ;19(2):1313-1321. Epub 2019 Dec 19. PMID: 32010304
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Frankincense
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antioxidant, antiapoptotic, and antifibrotic effects of the combination of liposomal resveratrol and carvedilol against doxorubicin-induced cardiomyopathy.Mar 14, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 Mar 15:e22492. Epub 2020 Mar 15. PMID: 32173980
Article Published Date : Mar 14, 2020
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Antioxidants, Cardioprotective, Chemoprotective Agents
[+]

Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2006 Nov 14 ;12(42):6835-41. PMID: 17106933
Article Published Date : Nov 13, 2006
Study Type : Animal Study
Additional Links
Substances : Vitamin C, Vitamin E
Diseases : Cholestasis, Liver Cirrhosis, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective
Additional Keywords : Natural Substance Synergy
[+]

Apigenin ameliorates hyperuricemic nephropathy.May 22, 2021

Pubmed Data : Phytomedicine. 2021 May 23 ;87:153585. Epub 2021 May 23. PMID: 34044255
Article Published Date : May 22, 2021
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : Hyperuricemia, Nephropathy
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Arctigenin could protect the kidney from unilateral ureteral obstruction induced injury and fibrogenesis.Jun 30, 2017

Pubmed Data : Phytomedicine. 2017 Jul 1 ;30:28-41. Epub 2017 Mar 10. PMID: 28545667
Article Published Date : Jun 30, 2017
Study Type : Animal Study
Additional Links
Substances : Arctigenin
Diseases : Kidney Fibrosis, Obstructive Nephropathy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:2043-2053. Epub 2018 Nov 26. PMID: 30551460
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Artesunate
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic
[+]

Ascorbic acid attenuated the inflammatory response and fibrosis in the lungs of rats treated with lipopolysaccharide.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : SAGE Open Med. 2019 ;7:2050312119828260. Epub 2019 Feb 4. PMID: 30783524
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Fibrosis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Nov 10 ;6(35):36984-97. PMID: 26474462
Article Published Date : Nov 09, 2015
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid, Naringenin
Diseases : Chronic Kidney Disease (CKD), Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jun 26 ;74:105712. Epub 2019 Jun 26. PMID: 31254954
Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Asiatic acid inhibits lliver fibrosis.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(2):e31350. Epub 2012 Feb 7. PMID: 22363627
Article Published Date : Dec 31, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic
[+]

Asiatic acid might be an effective candidate for pulmonary fibrosis and inflammation treatment.Apr 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 May ;89:1297-1309. Epub 2017 Mar 17. PMID: 28320097
Article Published Date : Apr 30, 2017
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Asiaticoside attenuates bleomycin-induced pulmonary fibrosis.Jun 29, 2020

Pubmed Data : Biochem Biophys Res Commun. 2020 Jun 30 ;527(3):662-667. Epub 2020 May 15. PMID: 32423816
Article Published Date : Jun 29, 2020
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Astaxanthin ameliorates high-fat diet-induced cardiac damage and fibrosis.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2021 Dec ;28(12):7012-7021. Epub 2021 Jul 30. PMID: 34867002
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Fibrosis, High Fat Diet
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, SIRT1 Activator
[+]

Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.Feb 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2019 Feb 19. Epub 2019 Feb 19. PMID: 30816496
Article Published Date : Feb 18, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Astaxanthin and vitamin E effectively improved hepatic gene expression.Mar 07, 2017

Pubmed Data : Int J Mol Sci. 2017 Mar 8 ;18(3). Epub 2017 Mar 8. PMID: 28282876
Article Published Date : Mar 07, 2017
Study Type : Animal Study
Additional Links
Substances : Astaxanthin, Vitamin E
Diseases : High Fat Diet, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, MicroRNA modulator
Additional Keywords : Gene Expression Regulation
[+]

Astaxanthin given in the post injury period significantly decreases fibrosis.Nov 10, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Med. 2019 Nov 11 ;8(11). Epub 2019 Nov 11. PMID: 31718054
Article Published Date : Nov 10, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Wound Healing
Pharmacological Actions : Anti-Fibrotic
[+]

Astaxanthin had a significant protective effect on liver fibrosis by suppressing multiple pro-fibrogenic factors.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2014 ;2014:954502. Epub 2014 Apr 17. PMID: 24860243
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic
[+]

Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue.Mar 01, 2016

Pubmed Data : J Nutr Biochem. 2016 Mar 2 ;43:27-35. Epub 2016 Mar 2. PMID: 28193580
Article Published Date : Mar 01, 2016
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Hepatic Steatosis, High Fat Diet, High Sugar Diet, Inflammation, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment.Jun 02, 2019

Pubmed Data : Biochim Biophys Acta Gen Subj. 2019 Jun 3. Epub 2019 Jun 3. PMID: 31170498
Article Published Date : Jun 02, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Astragaloside inhibits hepatic fibrosis by modulation of TGF-β1/Smad signalling pathway.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:3231647. Epub 2018 Apr 30. PMID: 29853950
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Astragaloside IV attenuates renal fibrosis through repressing epithelial-to-mesenchymal transition.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(8):5029-5038. Epub 2019 Aug 15. PMID: 31497219
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator, Renoprotective
[+]

Astragaloside IV improves bleomycin-induced pulmonary fibrosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:513. Epub 2017 Aug 8. PMID: 28848434
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Astragaloside IV improves renal function and fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:2431-2442. Epub 2018 Aug 6. PMID: 30122901
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Chronic Kidney Disease (CKD), Diabetic Complications, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway.Nov 14, 2019

Pubmed Data : J Ethnopharmacol. 2019 Nov 15:112404. Epub 2019 Nov 15. PMID: 31739105
Article Published Date : Nov 14, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Cardiovascular Diseases, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, MicroRNA modulator
[+]

Astragaloside IV inhibits excessive mesangial cell proliferation and renal fibrosis caused by diabetic nephropathy.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Oct ;18(4):3053-3061. Epub 2019 Aug 14. PMID: 31572545
Article Published Date : Sep 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Astragaloside IV inhibits hepatocellular carcinoma by continually suppressing the development of fibrosis and regulating pSmad3C/3L and Nrf2/HO-1 pathways.Jun 18, 2021

Pubmed Data : J Ethnopharmacol. 2021 Jun 19 ;279:114350. Epub 2021 Jun 19. PMID: 34157326
Article Published Date : Jun 18, 2021
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Liver Cancer
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Chemopreventive, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV modulates TGF‐β1‐dependent epithelial‐mesenchymal transition in bleomycin‐induced pulmonary fibrosisAug 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2018 Sep ;22(9):4354-4365. Epub 2018 Jul 4. PMID: 29971947
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

AstragalosideⅣ was beneficial against cardiac fibrosis.Jun 30, 2017

Pubmed Data : Phytomedicine. 2017 Jul 1 ;30:10-17. Epub 2017 Apr 19. PMID: 28545665
Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Hypoxia, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Astragalus saponins and glycyrrhizic acid synergistically alleviated hepatic fibrosis.Jun 05, 2016

Pubmed Data : J Ethnopharmacol. 2016 Jun 6 ;190:83-90. Epub 2016 Jun 6. PMID: 27282665
Article Published Date : Jun 05, 2016
Study Type : Animal Study
Additional Links
Substances : Astragalus, Licorice
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective
Additional Keywords : Natural Substance Synergy
[+]

Attenuating effects of dieckol on hypertensive nephropathy in spontaneously hypertensive rats.Apr 18, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Apr 19 ;22(8). Epub 2021 Apr 19. PMID: 33921823
Article Published Date : Apr 18, 2021
Study Type : Animal Study
Additional Links
Substances : Phlorotannins
Diseases : Hypertension
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Baicalin ameliorates pancreatic fibrosis by inhibiting the activation of pancreatic stellate cells in mice with chronic pancreatitis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:607133. Epub 2021 Jan 18. PMID: 33536916
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Pancreatitis
Pharmacological Actions : Anti-Fibrotic, Pancreato Protective Agents
[+]

Bellidifolin ameliorates isoprenaline-induced myocardial fibrosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:644886. Epub 2021 Apr 30. PMID: 33995055
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Xanthones
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2018 ;13(11):e0205535. Epub 2018 Nov 5. PMID: 30395570
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Fibrosis, Pesticide Toxicity
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Catalase Up-Regulation, Superoxide Dismutase Up-regulation
Problem Substances : Paraquat
[+]

Berberine alleviates adipose tissue fibrosis.May 27, 2018

Pubmed Data : Biomed Pharmacother. 2018 May 28 ;105:121-129. Epub 2018 May 28. PMID: 29852389
Article Published Date : May 27, 2018
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Fibrosis, Obesity
Pharmacological Actions : Anti-Fibrotic
[+]

Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus.Oct 20, 2021

Pubmed Data : Andrology. 2021 Oct 21. Epub 2021 Oct 21. PMID: 34674380
Article Published Date : Oct 20, 2021
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetic Complications, Erectile Dysfunction
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic
[+]

Berberine can ameliorate tubulointerstitial fibrosis in diabetic nephropathy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(8). Epub 2016 Aug 12. PMID: 27529235
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetes Mellitus: Type 1, Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Beta-sitosterol can be used to attenuate pulmonary fibrosis through suppression of EMT by inhibiting the TGF-β1/Snail pathway.Sep 03, 2019

Pubmed Data : J Agric Food Chem. 2019 Sep 4 ;67(35):9789-9795. Epub 2019 Aug 19. PMID: 31373816
Article Published Date : Sep 03, 2019
Study Type : Animal Study
Additional Links
Substances : Beta Sitosterol, Corn Silk
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Plant Extracts
[+]

Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.Dec 31, 2020

Pubmed Data : Phytomedicine. 2021 Jan ;81:153428. Epub 2020 Dec 1. PMID: 33341025
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Wnt/β-catenin signaling pathway modulation
[+]

Betulinic acid derivative BA5 had a potent anti-inflammatory activity on a model of parasite-driven heart disease.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2019 ;10:1257. Epub 2019 Jun 11. PMID: 31244833
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Chagas Disease, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Biochanin-A ameliorates pulmonary fibrosis.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2020 Aug 1 ;78:153298. Epub 2020 Aug 1. PMID: 32781391
Article Published Date : Jul 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Bisdemethoxycurcumin protects against renal fibrosis.Mar 14, 2019

Pubmed Data : Eur J Pharmacol. 2019 Mar 15 ;847:26-31. Epub 2019 Jan 17. PMID: 30660576
Article Published Date : Mar 14, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bisdemethoxycurcumin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney.Dec 31, 2020

Pubmed Data : Int Immunopharmacol. 2021 Jan ;90:107117. Epub 2020 Nov 6. PMID: 33162346
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Bixin
Diseases : Kidney Damage: Chemically-Induced, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective, Superoxide Dismutase Up-regulation
[+]

Bixin can be exploited therapeutically to alleviate renal interstitial fibrosis by targeting STAT6 signaling deactivation.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Dev Biol. 2020 ;8:576988. Epub 2020 Nov 17. PMID: 33313043
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Bixin
Diseases : Kidney Fibrosis, Renal tubulointerstitial fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Blackcurrant improves diabetic cardiovascular dysfunction by reducing inflammatory cytokines.Nov 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 Nov 22 ;13(11). Epub 2021 Nov 22. PMID: 34836432
Article Published Date : Nov 21, 2021
Study Type : Animal Study
Additional Links
Substances : Black Currant
Diseases : Diabetes Mellitus: Type 2, Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Blueberries have preventive effect on carbon tetrachloride-induced hepatic fibrosis.Aug 19, 2018

Pubmed Data : Zhonghua Gan Zang Bing Za Zhi. 2018 Aug 20 ;26(8):590-595. PMID: 30317790
Article Published Date : Aug 19, 2018
Study Type : Animal Study
Additional Links
Substances : Blueberry
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Blueberry attenuated liver fibrosis, protected intestinal epithelial barrier, and maintained the homeostasis of the gut microbiota.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Can J Gastroenterol Hepatol. 2019 ;2019:5236149. Epub 2019 Nov 22. PMID: 31886154
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Blueberry
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Gastrointestinal Agents, Gastroprotective, Hepatoprotective
Additional Keywords : Gut-liver axis
[+]

Both rosemary extracts administrated alone or in combination alleviated synergistically lung fibrosis.Oct 15, 2020

Pubmed Data : Nutr Cancer. 2020 Oct 16:1-12. Epub 2020 Oct 16. PMID: 33059466
Article Published Date : Oct 15, 2020
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
Additional Keywords : Natural Substance Synergy
[+]

Caffeic acid phenethyl ester is effective in resolving colon fibrosis in chronic inflammation.Aug 23, 2018

Pubmed Data : Pathol Res Pract. 2018 Aug 24. Epub 2018 Aug 24. PMID: 30170869
Article Published Date : Aug 23, 2018
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Colitis, Fibrosis, Gastrointestinal Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Calcitriol ameliorates kidney injury through reducing podocytopathy, tubular injury, inflammation and fibrosis.Mar 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Kobe J Med Sci. 2020 Mar 27 ;65(5):E153-E163. Epub 2020 Mar 27. PMID: 32249272
Article Published Date : Mar 26, 2020
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Kidney Damage, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Renoprotective
[+]

Camel milk either alone or in combination with bee honey ameliorated the toxic effects of carbon tetrachloride.May 29, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 May 30:1-10. Epub 2016 May 30. PMID: 27455095
Article Published Date : May 29, 2016
Study Type : Animal Study
Additional Links
Substances : Camel Milk , Honey
Diseases : Chemically-Induced Liver Damage, Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediating renal inflammation and fibrosis.Jan 10, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Sci (Lond). 2020 12 11 ;134(23):3175-3193. PMID: 33241846
Article Published Date : Jan 10, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosine
Diseases : Diabetic Nephropathy, Inflammation, Kidney Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Anti-Inflammatory Agents, Renoprotective
[+]

Carvacrol suppresses the progression of liver fibrosis.Jan 31, 2019

Pubmed Data : Immunopharmacol Immunotoxicol. 2019 Feb ;41(1):163-171. Epub 2019 Feb 1. PMID: 30706740
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Carvacrol
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Celastrol exerts anti-inflammatory effect in liver fibrosis.Nov 18, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 Nov 19. Epub 2019 Nov 19. PMID: 31742890
Article Published Date : Nov 18, 2019
Study Type : Animal Study
Additional Links
Substances : Celastrol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis.Jan 31, 2020

Pubmed Data : Phytomedicine. 2020 Feb ;67:153160. Epub 2019 Dec 26. PMID: 31901889
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Celastrol
Diseases : Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Chamomile hydroalcoholic extract may be able to diminish the toxic effects of bleomycin on the lung tissues.Sep 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Tanaffos. 2018 Oct ;17(4):264-271. PMID: 31143217
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Chamomile
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

Chlorogenic acid alleviates hyperglycemia-induced cardiac fibrosis.Nov 16, 2020

Pubmed Data : Mol Nutr Food Res. 2020 Nov 17:e2000810. Epub 2020 Nov 17. PMID: 33200558
Article Published Date : Nov 16, 2020
Study Type : Animal Study
Additional Links
Substances : Chlorogenic Acid
Diseases : Cardiomyopathy, Hyperglycemia, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Chlorogenic acid might be a new anti-fibrosis agent that improves liver fibrosis.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2017 ;8:929. Epub 2017 Dec 19. PMID: 29311932
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Chlorogenic Acid
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Chrysin ameliorates cyclosporine-A-induced renal fibrosis.Sep 22, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Sep 23 ;22(19). Epub 2021 Sep 23. PMID: 34638597
Article Published Date : Sep 22, 2021
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Chrysin inhibits advanced glycation end products-induced kidney fibrosis.Jul 08, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Jul 9 ;10(7). Epub 2018 Jul 9. PMID: 29987200
Article Published Date : Jul 08, 2018
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Advanced Glycation End products (AGE)
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Cinnamon decreases fibrotic symptoms and markers in murine colitis.Mar 20, 2017

Pubmed Data : Mol Nutr Food Res. 2017 Mar 21. Epub 2017 Mar 21. PMID: 28324642
Article Published Date : Mar 20, 2017
Study Type : Animal Study
Additional Links
Substances : Cinnamon
Diseases : Colitis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jan ;109:892-901. Epub 2018 Nov 5. PMID: 30551543
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Autophagy Up-regulation, Hepatoprotective
[+]

Coenzyme Q10 inhibits the activation of pancreatic stellate cells.Nov 02, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Nov 3 ;8(54):92300-92311. Epub 2017 Sep 23. PMID: 29190916
Article Published Date : Nov 02, 2017
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis.Jul 26, 2020

Pubmed Data : Toxicol Mech Methods. 2020 Jul 27:1-23. Epub 2020 Jul 27. PMID: 32718261
Article Published Date : Jul 26, 2020
Study Type : Animal Study
Additional Links
Substances : Curcumin, Pomegranate
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

CoQ10 may be a therapeutic candidate for antifibrotic methods.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:8039694. Epub 2019 Feb 7. PMID: 30881598
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model.Nov 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Zhejiang Univ Sci B. 2011 Dec ;12(12):1024-33. PMID: 22135152
Article Published Date : Nov 30, 2011
Study Type : Animal Study
Additional Links
Substances : Medicinal Mushrooms
Diseases : Kidney Failure: Chronic, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
Additional Keywords : Plant Extracts
[+]

Crocin attenuates CCl 4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats.Nov 30, 2020

Pubmed Data : Hum Exp Toxicol. 2020 Dec ;39(12):1639-1649. Epub 2020 Jul 7. PMID: 32633567
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor
[+]

Crocin attenuates isoprenaline-induced myocardial fibrosis.Aug 06, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug 7. Epub 2019 Aug 7. PMID: 31392383
Article Published Date : Aug 06, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Drug Toxicity: Isoprenaline, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis.Aug 25, 2019

Pubmed Data : Life Sci. 2019 Aug 26:116794. Epub 2019 Aug 26. PMID: 31465731
Article Published Date : Aug 25, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin restrained the activation of hepatic stellate cells through the lnc-LFAR1/MTF-1/GDNF axis, thereby ameliorating liver fibrosis.Dec 08, 2020

Pubmed Data : Cell Cycle. 2020 Dec 9:1-11. Epub 2020 Dec 9. PMID: 33295246
Article Published Date : Dec 08, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Crocin: a protective natural antioxidant against pulmonary fibrosis induced by bleomycin.Jan 28, 2020

Pubmed Data : Pharmacol Rep. 2020 Jan 29. Epub 2020 Jan 29. PMID: 31997260
Article Published Date : Jan 28, 2020
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Chemoprotective Agents
[+]

Cucurbitacin B could significantly suppress releases of inflammatory cytokines and improve liver fibrosis induced by concanavalin A.May 24, 2020

Pubmed Data : Basic Clin Pharmacol Toxicol. 2020 May 25. Epub 2020 May 25. PMID: 32452080
Article Published Date : May 24, 2020
Study Type : Animal Study
Additional Links
Substances : Cucurbitacin B
Diseases : Liver Damage: Drug-Induced, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Transforming growth factor beta (TGF-β) inhibitor
Problem Substances : Concanavalin A
[+]

Cucurbitacin E glucoside inhibits testosterone-induced experimental benign prostatic hyperplasia.Jul 11, 2019

Pubmed Data : Drug Chem Toxicol. 2019 Jul 12:1-11. Epub 2019 Jul 12. PMID: 31298051
Article Published Date : Jul 11, 2019
Study Type : Animal Study
Additional Links
Substances : Cucurbitacin E
Diseases : Prostatic Hyperplasia: Benign
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Antiproliferative
[+]

Curcumin ameliorates chemically-induced liver damage and fibrosis in rats.Oct 01, 2011

Pubmed Data : Ann Hepatol. 2011 Oct 1 ;10(4):516-30. PMID: 21911894
Article Published Date : Oct 01, 2011
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis.Nov 01, 2005

Pubmed Data : Kidney Int. 2005 Nov;68(5):2042-9. PMID: 16221204
Article Published Date : Nov 01, 2005
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Glomerulonephritis, Kidney Fibrosis, Proteinuria
Pharmacological Actions : Anti-Fibrotic, Enzyme Inhibitors, Renoprotective
[+]

Curcumin has a prophylactic effect on hepatic fibrosis. May 01, 2006

Pubmed Data : Zhonghua Gan Zang Bing Za Zhi. 2006 May;14(5):337-40. PMID: 16732906
Article Published Date : May 01, 2006
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Apoptotic, Enzyme Inhibitors, Hepatoprotective
[+]

Curcumin inhibits liver fibrosis. Jan 01, 2002

Pubmed Data : J Pharm Pharmacol. 2002 Jan;54(1):119-26. PMID: 11829122
Article Published Date : Jan 01, 2002
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Curcumin is a potent antifibrotic agent and a promising treatment for diabetic nephropathy.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2017 ;2017:1516985. Epub 2017 Jan 17. PMID: 28194406
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Renoprotective
[+]

Curcumin might be an effective antifibrotic drug in the treatment of chronic kidney disease.Jul 01, 2004

Pubmed Data : Kidney Int. 2004 Jul;66(1):112-20. PMID: 15200418
Article Published Date : Jul 01, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Kidney Diseases, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Curcumin prevents liver fibrosis.Oct 01, 2009

Pubmed Data : J Nat Med. 2009 Oct;63(4):415-20. Epub 2009 Jun 25. PMID: 19554395
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Apoptotic
[+]

Curcumin was beneficial in acute lung injury and lung fibrosis.Aug 22, 2019

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2019 Aug 23. Epub 2019 Aug 23. PMID: 31441735
Article Published Date : Aug 22, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Lung Injury: Acute, Pulmonary Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.Jan 26, 2020

Pubmed Data : Phytother Res. 2020 Jan 27. Epub 2020 Jan 27. PMID: 31989700
Article Published Date : Jan 26, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Dandelion has antifibrotic activity in chemically-induced liver damage in mice.Aug 09, 2010

Pubmed Data : J Ethnopharmacol. 2010 Aug 9;130(3):569-77. Epub 2010 Jun 2. PMID: 20561925
Article Published Date : Aug 09, 2010
Study Type : Animal Study
Additional Links
Substances : Dandelion
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Danshensu alleviates bleomycin-induced pulmonary fibrosis.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Bioengineered. 2021 Dec ;12(1):3113-3124. PMID: 34187349
Article Published Date : Nov 30, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

Danshensu, a novel indoleamine 2,3-dioxygenase1 inhibitor, exerts anti-hepatic fibrosis effects via inhibition of JAK2-STAT3 signaling.Sep 30, 2019

Pubmed Data : Phytomedicine. 2019 Oct ;63:153055. Epub 2019 Jul 27. PMID: 31377585
Article Published Date : Sep 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

DHA may be beneficial in preventing chronic pancreatitis by suppressing pancreatic expression of fibrotic mediators.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Prev. 2019 Dec ;24(4):233-239. Epub 2019 Dec 30. PMID: 31950023
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : DHA (Docosahexaenoic Acid)
Diseases : Pancreatitis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Didymin alleviates hepatic fibrosis. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 ;40(6):1422-1432. Epub 2016 Dec 20. PMID: 27997902
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacol Res Perspect. 2018 04 ;6(2):e00385. Epub 2018 Feb 19. PMID: 29468071
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin, Tetrahydrocurcumin
Diseases : Cardiac Hypertrophy, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective
[+]

Diosmin ameliorates inflammation, insulin resistance, and fibrosis in an experimental model of non-alcoholic steatohepatitis.Jan 14, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2020 08 15 ;401:115101. Epub 2020 Jun 6. PMID: 32512072
Article Published Date : Jan 14, 2020
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice.Nov 14, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Nov 15. Epub 2019 Nov 15. PMID: 31732951
Article Published Date : Nov 14, 2019
Study Type : Animal Study
Additional Links
Substances : Diosgenin
Diseases : Fibrosis, Lung Injury: Acute, Pesticide Toxicity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
Problem Substances : Paraquat
[+]

Diosmin attenuates radiation-induced hepatic fibrosis.Dec 31, 2016

Pubmed Data : Biochem Cell Biol. 2017 06 ;95(3):400-414. Epub 2016 Nov 21. PMID: 28177765
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Liver Cirrhosis, Radiation Induced Illness
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
[+]

Docosahexaenoic acid attenuates carbon tetrachloride-induced hepatic fibrosis in rats.Oct 12, 2017

Pubmed Data : Int Immunopharmacol. 2017 Oct 13 ;53:56-62. Epub 2017 Oct 13. PMID: 29035816
Article Published Date : Oct 12, 2017
Study Type : Animal Study
Additional Links
Substances : DHA (Docosahexaenoic Acid)
Diseases : Chemically-Induced Liver Damage, Fibrosis: Liver
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Lipid Res. 2015 Oct ;56(10):1936-46. Epub 2015 Aug 27. PMID: 26315048
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Substances : DHA (Docosahexaenoic Acid)
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
Anti Therapeutic Actions : Western Diet
[+]

Effect and mechanism of total flavonoids of Lichi Semen on CCl_4-induced liver fibrosis.Nov 30, 2020

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2020 Dec ;45(23):5722-5731. PMID: 33496112
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Litchi
Diseases : Chemically-Induced Liver Damage, Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Effect of baicalin on expression of fibrogenic factors TGF-β1, mmp2 and timp2 in tissue of mice with pulmonary fibrosis.Nov 30, 2020

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2020 Dec ;45(23):5738-5744. PMID: 33496114
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Effect of paeoniflorin on acute lung injury induced by influenza A virus.Oct 31, 2021

Pubmed Data : Phytomedicine. 2021 Nov ;92:153724. Epub 2021 Aug 21. PMID: 34509953
Article Published Date : Oct 31, 2021
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Influenza A, Lung Injury: Acute
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Effectiveness of Hypericum perforatum extract in the treatment of corrosive esophageal burns.May 16, 2021

Pubmed Data : J Invest Surg. 2021 May 17:1-6. Epub 2021 May 17. PMID: 33998353
Article Published Date : May 16, 2021
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Burns
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Effects of shikonin from Zicao on high-fat diet-induced nonalcoholic fatty liver disease in rats.Oct 31, 2020

Pubmed Data : Pak J Pharm Sci. 2020 Nov ;33(6):2527-2533. PMID: 33867326
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Shikonin
Diseases : High Fat Diet, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

EGCG could attenuate testosterone-induced benign prostatic hyperplasia and fibrosis.Aug 31, 2018

Pubmed Data : Int Immunopharmacol. 2018 Sep 1 ;64:162-169. Epub 2018 Sep 1. PMID: 30179845
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Prostatic Hyperplasia: Benign
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

EGCG might be regarded as a prospective therapeutic candidate in modulating diabetic nephropathy.Aug 20, 2017

Pubmed Data : J Agric Food Chem. 2017 Aug 21. Epub 2017 Aug 21. PMID: 28823168
Article Published Date : Aug 20, 2017
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Hypoglycemic Agents
[+]

Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Pharm Sin B. 2019 Jul ;9(4):724-733. Epub 2019 Apr 22. PMID: 31384533
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Emodin ameliorates renal damage and podocyte injury in a model of diabetic nephropathy.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Metab Syndr Obes. 2021 ;14:1253-1266. Epub 2021 Mar 18. PMID: 33776462
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Renoprotective
[+]

Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biochem Biophys Res Commun. 2021 Jan 1 ;534:279-285. Epub 2020 Dec 4. PMID: 33288199
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis.Jul 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2021 Aug ;146(4):216-225. Epub 2021 May 1. PMID: 34116735
Article Published Date : Jul 31, 2021
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Autophagy Up-regulation, Renoprotective
[+]

Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):1305-1313. PMID: 34607503
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Eriobotrya japonica leaf extract potentially provides cardio-protective effects against hypertension-induced cardiac apoptosis and fibrosis.May 30, 2018

Pubmed Data : Int J Mol Sci. 2018 May 31 ;19(6). Epub 2018 May 31. PMID: 29857545
Article Published Date : May 30, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Loquat
Diseases : Hypertension
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Cardioprotective
[+]

Evodiamine could ameliorate liver fibrosis in animals. Sep 20, 2017

Pubmed Data : J Nat Med. 2017 Sep 21. Epub 2017 Sep 21. PMID: 28936800
Article Published Date : Sep 20, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Evodiamine
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Fermented black radish may be an effective dietary supplement for ameliorating NAFLD.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2019 Oct ;7(10):3327-3337. Epub 2019 Sep 9. PMID: 31660146
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Radish
Diseases : Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Fermented rice bran supplementation prevents the development of intestinal fibrosis due to DSS-induced inflammation.May 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2021 May 30 ;13(6). Epub 2021 May 30. PMID: 34070845
Article Published Date : May 29, 2021
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Rice Bran
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Gastroprotective
[+]

Ferulic acid combined with astragaloside IV reduced the degree of pulmonary fibrosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:8845798. Epub 2021 Mar 2. PMID: 33763150
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Astragaloside, Ferulic acid
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Natural Substance Synergy
[+]

Fisetin alleviated bleomycin-induced pulmonary fibrosis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:553690. Epub 2020 Dec 14. PMID: 33381023
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Fisetin alleviates atrial inflammation, remodelling, and vulnerability to atrial fibrillation after myocardial infarction.Nov 29, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Heart J. 2019 Nov 30 ;60(6):1398-1406. Epub 2019 Oct 31. PMID: 31666455
Article Published Date : Nov 29, 2019
Study Type : Animal Study
Additional Links
Substances : Fisetin, Flavonoids
Diseases : Myocardial Fibrosis , Myocardial Infarction
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fisetin alleviates hepatic and adipocyte fibrosis and insulin resistance.Aug 25, 2020

Pubmed Data : J Med Food. 2020 Aug 26. Epub 2020 Aug 26. PMID: 32856978
Article Published Date : Aug 25, 2020
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Fibrosis, Inflammation, Obesity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Foeniculum vulgare root bark may be a promising agent against hepatic fibrosis.Aug 20, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2017 Aug 21 ;23(31):5722-5731. PMID: 28883697
Article Published Date : Aug 20, 2017
Study Type : Animal Study
Additional Links
Substances : Fenugreek
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Fucoidan inhibits radiation-induced pneumonitis and lung fibrosis.Oct 18, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2018 Oct 19 ;16(10). Epub 2018 Oct 19. PMID: 30347679
Article Published Date : Oct 18, 2018
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Fibrosis, Pneumonitis, Radiotherapy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Fucoxanthin inhibits profibrotic protein expression in vitro and attenuates bleomycin-induced lung fibrosis in vivo.Sep 14, 2017

Pubmed Data : Eur J Pharmacol. 2017 Sep 15 ;811:199-207. Epub 2017 Jun 19. PMID: 28642129
Article Published Date : Sep 14, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoxanthin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

Fucoxanthin regulates Nrf2 signaling to decrease oxidative stress and improves renal fibrosis.Nov 11, 2021

Pubmed Data : Eur J Pharmacol. 2021 Nov 12 ;913:174629. Epub 2021 Nov 12. PMID: 34780751
Article Published Date : Nov 11, 2021
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Nrf2 activation, Renoprotective, SIRT1 Activator
[+]

G. glabra may be suggested for the prevention and treatment of pulmonary fibrosis and inflammation.May 08, 2019

Pubmed Data : Drug Chem Toxicol. 2019 May 9:1-7. Epub 2019 May 9. PMID: 31072167
Article Published Date : May 08, 2019
Study Type : Animal Study
Additional Links
Substances : Licorice
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Malondialdehyde Down-regulation
[+]

Galangin ameliorated pulmonary fibrosis in vivo and in vitro by regulating epithelial-mesenchymal transition.Sep 30, 2020

Pubmed Data : Bioorg Med Chem. 2020 Oct 1 ;28(19):115663. Epub 2020 Jul 28. PMID: 32912432
Article Published Date : Sep 30, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Galangin attenuates isoproterenol-induced inflammation and fibrosis in the cardiac tissue.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:585163. Epub 2020 Nov 30. PMID: 33328989
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective
Problem Substances : Isoproterenol
[+]

Gallic acid has therapeutic potential for the treatment of heart failure-induced pulmonary fibrosis.Nov 30, 2017

Pubmed Data : Vascul Pharmacol. 2017 Dec ;99:74-82. Epub 2017 Oct 31. PMID: 29097327
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Gallic Acid
Diseases : Heart Failure, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Gamma-tocotrienol supplementation is effective in attenuating NAFLD and fibrosis.Jan 10, 2018

Pubmed Data : Mol Nutr Food Res. 2018 11 ;62(21):e1800519. Epub 2018 Sep 9. PMID: 30183139
Article Published Date : Jan 10, 2018
Study Type : Animal Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol
Diseases : Inflammation, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
Problem Substances : High Fructose Corn Syrup
[+]

Gastrodin attenuates carbon tetrachloride-induced kidney inflammation and fibrosis.Apr 30, 2020

Pubmed Data : Food Funct. 2020 May 1 ;11(5):4615-4624. Epub 2020 May 13. PMID: 32400831
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Inflammation, Kidney Damage, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy
[+]

Gastrodin improves nonalcoholic fatty liver disease.Jul 22, 2021

Pubmed Data : Hepatology. 2021 Jul 23. Epub 2021 Jul 23. PMID: 34297426
Article Published Date : Jul 22, 2021
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective
[+]

Genistein could be a novel therapeutic agent in treating chronic liver damage and liver fibrosis.Nov 18, 2016

Pubmed Data : Chem Biol Interact. 2016 Nov 19 ;261:80-85. Epub 2016 Nov 19. PMID: 27876602
Article Published Date : Nov 18, 2016
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Geraniol has a hepatoprotective upshot on liver fibrosis caused by carbon tetrachloride.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pak J Biol Sci. 2020 Jan ;23(12):1650-1658. PMID: 33274899
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Geraniol prevents the atherogenic diet induced fibrosis in experimental hamsters.Sep 04, 2015

Pubmed Data : Eur J Pharmacol. 2015 Sep 5 ;762:102-11. Epub 2015 May 22. PMID: 26004525
Article Published Date : Sep 04, 2015
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Atherosclerosis, Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Ginger extract protects the heart against inflammation and fibrosis in diabetes.Sep 01, 2020

Pubmed Data : Can J Diabetes. 2020 Sep 2. Epub 2020 Sep 2. PMID: 33162372
Article Published Date : Sep 01, 2020
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Cardiomyopathy, Diabetic Complications, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Plant Extracts
[+]

Ginsenoside 25-OCH3-PPD could be used to curve the development of hepatic fibrosis.Jul 10, 2018

Pubmed Data : J Agric Food Chem. 2018 Jul 11 ;66(27):7023-7035. Epub 2018 Jul 2. PMID: 29929367
Article Published Date : Jul 10, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Hepatoprotective
[+]

Ginsenoside Rg1 ameliorates liver fibrosis.May 14, 2018

Pubmed Data : Biofactors. 2018 May 15. Epub 2018 May 15. PMID: 29761840
Article Published Date : May 14, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Ginsenoside Rg1 may suppress cigarette smoke-induced airway fibrosis in pulmonary fibroblasts and COPD rats.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2017 ;2017:6510198. Epub 2017 Mar 21. PMID: 28421197
Article Published Date : Dec 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Chronic Obstructive Pulmonary Disease, Lung Injury: Smoke-Induced, Smoking: Pulmonary
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Anti-Fibrotic, Chronic Obstructive Pulmonary Disease, Ginsenosides, Lung Injury: Smoke-Induced, Smoking: Pulmonary
[+]

Ginsenoside Rg2 alleviates myocardial fibrosis.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2021 Dec ;59(1):106-113. PMID: 33535854
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Ginsenoside Rg3 decreases fibrotic and invasive nature of endometriosis.Dec 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Dec 15 ;7(1):17670. Epub 2017 Dec 15. PMID: 29247225
Article Published Date : Dec 14, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Endometriosis
Pharmacological Actions : Anti-Fibrotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, MicroRNA modulator
[+]

Ginsenoside Rh2 is suitable to develop as an alternative remedy for cardiac fibrosis.Jun 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Jun 26 ;18(7). Epub 2017 Jun 26. PMID: 28672855
Article Published Date : Jun 25, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetes Mellitus: Type 1, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Ginsenoside-Rg1 acts as an IDO1 inhibitor and protects against liver fibrosis.Feb 19, 2021

Pubmed Data : Phytomedicine. 2021 Feb 20 ;84:153524. Epub 2021 Feb 20. PMID: 33667840
Article Published Date : Feb 19, 2021
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Grape seed extracts may improve the quality of life of lung fibrosis patients by inhibiting MMP-9 and TGF-β1 expression in the lungs.Mar 11, 2017

Pubmed Data : Toxicol Lett. 2017 Mar 12 ;273:1-9. Epub 2017 Mar 12. PMID: 28300665
Article Published Date : Mar 11, 2017
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.Dec 20, 2019

Pubmed Data : Chem Biol Interact. 2019 Dec 21:108926. Epub 2019 Dec 21. PMID: 31874164
Article Published Date : Dec 20, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Hawthorn herbal preparation from Crataegus oxyacantha attenuates carbon tetrachloride-induced hepatic fibrosis.Nov 23, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Nov 24 ;9(12). Epub 2020 Nov 24. PMID: 33255507
Article Published Date : Nov 23, 2020
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Healing potential of Spirulina platensis for skin wounds.Feb 06, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Feb 7 ;137:111349. Epub 2021 Feb 7. PMID: 33567349
Article Published Date : Feb 06, 2021
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Scars, Wound Healing
Pharmacological Actions : Anti-Fibrotic
[+]

Helenalin attenuates alcohol-induced hepatic fibrosis.May 31, 2014

Pubmed Data : Fitoterapia. 2014 Jun ;95:203-13. Epub 2014 Apr 2. PMID: 24704336
Article Published Date : May 31, 2014
Study Type : Animal Study
Additional Links
Substances : Helenalin
Diseases : Alcohol Toxicity , Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Hepatoprotective effect of kombucha tea in rodent model of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.May 12, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 May 13 ;20(9). Epub 2019 May 13. PMID: 31086120
Article Published Date : May 12, 2019
Study Type : Animal Study
Additional Links
Substances : Kombucha Tea
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective
[+]

Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis.Oct 21, 2021

Pubmed Data : Food Funct. 2021 Oct 22. Epub 2021 Oct 22. PMID: 34676843
Article Published Date : Oct 21, 2021
Study Type : Animal Study
Additional Links
Substances : Piceatannol
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Hepatoprotective effect of ultrasonicated ginseng berry extract on a rat mild bile duct ligation model.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2019 Oct ;43(4):606-617. Epub 2018 Aug 10. PMID: 31695567
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Ginseng, Ginsenosides
Diseases : Liver Failure: Acute, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation.Dec 26, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Dec 27 ;9(1):20026. Epub 2019 Dec 27. PMID: 31882854
Article Published Date : Dec 26, 2019
Study Type : Animal Study
Additional Links
Substances : Yoghurt
Diseases : High Fat Diet, Metabolic Syndrome X, Obesity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
[+]

Honokiol ameliorates pulmonary fibrosis.Feb 03, 2020

Pubmed Data : Toxicol Appl Pharmacol. 2020 Feb 4:114913. Epub 2020 Feb 4. PMID: 32032644
Article Published Date : Feb 03, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Honokiol deserves further consideration as a candidate therapeutic agent for epidural fibrosis.Oct 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2020 Oct 22. Epub 2020 Oct 22. PMID: 33125121
Article Published Date : Oct 21, 2020
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Hydrogen water can inhibit the development of fibrosis in kidney.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2017 ;40(5):610-615. PMID: 28458345
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Hydrogen water protects hepatocytes from injury by scavenging hydroxyl radicals and thereby suppresses liver fibrogenesis in mice.May 31, 2014

Pubmed Data : Hepatol Res. 2014 Jun ;44(6):663-677. Epub 2013 Jun 18. PMID: 23682614
Article Published Date : May 31, 2014
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective
[+]

Hydroxysafflor yellow A attenuates bleomycin-induced pulmonary fibrosis.Mar 31, 2016

Pubmed Data : Phytother Res. 2016 Apr ;30(4):577-87. Epub 2016 Jan 18. PMID: 26777519
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Safflower
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Hyperoside attenuates bleomycin-induced pulmonary fibrosis development.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:550955. Epub 2020 Oct 22. PMID: 33192501
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Chemoprotective Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hyperoside protects against heart failure-induced liver fibrosis.Sep 30, 2019

Pubmed Data : Acta Histochem. 2019 Oct ;121(7):804-811. Epub 2019 Jul 26. PMID: 31353051
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Heart Failure, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Hyperoside protects against pressure overload-induced cardiac remodelling.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;51(2):827-841. Epub 2018 Nov 22. PMID: 30466089
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective
[+]

Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Jun ;114:108851. Epub 2019 Apr 6. PMID: 30965234
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Iso-alpha acids from hops inhibit hepatic steatosis, inflammation, and fibrosis.Nov 30, 2018

Pubmed Data : Lab Invest. 2018 Dec ;98(12):1614-1626. Epub 2018 Aug 8. PMID: 30089858
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Hops
Diseases : Fibrosis: Liver, Hepatic Steatosis, Inflammation, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis.Mar 14, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Mar 15 ;6:23097. Epub 2016 Mar 15. PMID: 26975571
Article Published Date : Mar 14, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Isorhamnetin alleviates steatosis and fibrosis in mice with nonalcoholic steatohepatitis.Jan 06, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 11 7 ;9(1):16210. Epub 2019 Nov 7. PMID: 31700054
Article Published Date : Jan 06, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Isorhamnetin inhibits liver fibrosis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2019 ;2019:6175091. Epub 2019 Jul 31. PMID: 31467486
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Juglanin alleviates bleomycin-induced lung injury.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Jul ;127:110119. Epub 2020 Apr 7. PMID: 32276127
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Walnut
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Kaempferol inhibits the progression of silica-induced pulmonary fibrosis.Sep 26, 2019

Pubmed Data : DNA Cell Biol. 2019 Sep 27. Epub 2019 Sep 27. PMID: 31560574
Article Published Date : Sep 26, 2019
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Kaempferol may prove to be a novel agent for the treatment of liver fibrosis or other fibroproliferative diseases.Jul 04, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 Jul 5. Epub 2019 Jul 5. PMID: 31273920
Article Published Date : Jul 04, 2019
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Kefir peptides alleviate high-fat diet-induced atherosclerosis.May 28, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 May 29 ;10(1):8802. Epub 2020 May 29. PMID: 32472055
Article Published Date : May 28, 2020
Study Type : Animal Study
Additional Links
Substances : Kefir
Diseases : Atherosclerosis, High Fat Diet
Pharmacological Actions : Anti-Fibrotic, Antioxidants
[+]

Korean red ginseng attenuates hyperglycemia-induced renal inflammation and fibrosis.May 22, 2020

Pubmed Data : J Ethnopharmacol. 2020 May 23 ;254:112693. Epub 2020 Feb 26. PMID: 32112899
Article Published Date : May 22, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Diabetic Nephropathy, Hyperglycemia, Inflammation, Kidney Damage, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Autophagy Up-regulation, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Krill oil might be a new candidate for treatment of iron overload-induced toxicity.Jan 31, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2020 Feb ;27(4):3950-3961. Epub 2019 Dec 10. PMID: 31823254
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Krill
Diseases : Iron Overload, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet.Oct 09, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dig Liver Dis. 2019 Oct 10. Epub 2019 Oct 10. PMID: 31607566
Article Published Date : Oct 09, 2019
Study Type : Animal Study
Additional Links
Substances : L-Carnitine
Diseases : Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Hepatoprotective
[+]

L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction.Sep 17, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Intern Med. 2020 Sep 18. Epub 2020 Sep 18. PMID: 32942841
Article Published Date : Sep 17, 2020
Study Type : Animal Study
Additional Links
Substances : L-Carnitine
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Lactobacillus rhamnosus GG reduces hepatic fibrosis in animals.Jan 04, 2017

Pubmed Data : Nutr Hosp. 2017 06 5 ;34(3):702-709. Epub 2017 Jun 5. PMID: 28627210
Article Published Date : Jan 04, 2017
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus GG
Diseases : Fibrosis, Liver Disease
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation
[+]

Lactoferrin contributes a renoprotective effect in acute kidney injury and early renal fibrosis.May 07, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceutics. 2020 May 8 ;12(5). Epub 2020 May 8. PMID: 32397266
Article Published Date : May 07, 2020
Study Type : Animal Study
Additional Links
Substances : Lactoferrin
Diseases : Kidney Damage, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
Additional Keywords : Gene Expression Regulation
[+]

Lemon balm and rosmarinic acid could improve liver damage by non-alcoholic lipid accumulation and may be promising medications to treat NASH.Apr 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Apr 22 ;12(4). Epub 2020 Apr 22. PMID: 32331258
Article Published Date : Apr 21, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Lemon Balm, Rosmarinic acid
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Lingonberry anthocyanins inhibit hepatic stellate cell activation and liver fibrosis via TGFβ/Smad/ERK signaling pathway.Nov 16, 2021

Pubmed Data : J Agric Food Chem. 2021 Nov 17 ;69(45):13546-13556. Epub 2021 Nov 4. PMID: 34735147
Article Published Date : Nov 16, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Anthocyanins, Lingonberry
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Liposomal astaxanthin has applicable protective and therapeutic potential to treat alcohol-induced liver diseases.Aug 19, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Aug 20 ;20(16). Epub 2019 Aug 20. PMID: 31434227
Article Published Date : Aug 19, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Alcohol Toxicity , Alcoholic Liver Disease, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Liquiritigenin attenuates isoprenaline‑induced myocardial fibrosisSep 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2021 Oct ;24(4). Epub 2021 Jul 30. PMID: 34328199
Article Published Date : Sep 30, 2021
Study Type : Animal Study
Additional Links
Substances : Liquiritigenin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective, Transforming growth factor beta (TGF-β) upregulation
[+]

Liquiritigenin has the potential for effective treatment of liver fibrosis.Dec 09, 2018

Pubmed Data : Phytomedicine. 2018 Dec 10 ;62:152780. Epub 2018 Dec 10. PMID: 31121384
Article Published Date : Dec 09, 2018
Study Type : Animal Study
Additional Links
Substances : Liquiritigenin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Loquat seed inhibits fatty liver, inflammation and fibrosis in the treatment of non-alcoholic fatty liver disease. Feb 01, 2010

Pubmed Data : J Pharm Pharmacol. 2010 Feb;62(2):241-6. PMID: 20487204
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Loquat Seeds
Diseases : Fatty Liver, Inflammation, Liver Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Plant Extracts
[+]

Low molecular weight fucoidan attenuating pulmonary fibrosis.Nov 30, 2021

Pubmed Data : Carbohydr Polym. 2021 Dec 1 ;273:118567. Epub 2021 Aug 19. PMID: 34560978
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Pulmonary Fibrosis
Pharmacological Actions : Anti-Fibrotic, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Low molecular weight fucoidan can inhibit the fibrosis of diabetic kidneys by regulating the kidney lipid metabolism.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Diabetes Res. 2021 ;2021:7618166. Epub 2021 Nov 24. PMID: 34869779
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Kidney Damage, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hypolipidemic, Renoprotective
[+]

Low-level laser therapy attenuates lung inflammation and airway remodeling in a murine model of idiopathic pulmonary fibrosis.Dec 31, 2019

Pubmed Data : J Photochem Photobiol B. 2020 Jan ;203:111731. Epub 2019 Dec 4. PMID: 31935633
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Lung Inflammation, Pulmonary Fibrosis
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2019 ;11(4):2590-2602. Epub 2019 Apr 15. PMID: 31105865
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Lung injury induced by bisphenol A is ameliorated by selenium supplementation.Feb 11, 2017

Pubmed Data : Pathophysiology. 2017 Feb 12. Epub 2017 Feb 12. PMID: 28285737
Article Published Date : Feb 11, 2017
Study Type : Animal Study
Additional Links
Substances : Selenium
Diseases : Bisphenol Toxicity, Fibrosis, Lung Damage
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Bisphenol Toxicity, Fibrosis, Lung Damage, Selenium
Problem Substances : Bisphenol A
[+]

Luteolin ameliorated the myocardium fibrosis of heart failure.Jan 22, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 Jan 23 ;7:41017. Epub 2017 Jan 23. PMID: 28112209
Article Published Date : Jan 22, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Heart Failure
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Luteolin ameliorates diet-induced obesity and its comorbidities.Oct 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Oct 3 ;10(10). Epub 2018 Oct 3. PMID: 30282902
Article Published Date : Oct 02, 2018
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Fibrosis, Hepatic Steatosis, Insulin Resistance, Obesity
Pharmacological Actions : Anti-Fibrotic, Pancreato Protective Agents
Additional Keywords : Anti-Obesity Agents
[+]

Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro.Nov 23, 2010

Pubmed Data : J Agric Food Chem. 2010 Nov 24 ;58(22):11653-61. Epub 2010 Oct 19. PMID: 20958047
Article Published Date : Nov 23, 2010
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Lycopene corrects metabolic syndrome and liver injury induced by high fat diet.Jul 05, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Jul 6 ;141:111831. Epub 2021 Jul 6. PMID: 34237596
Article Published Date : Jul 05, 2021
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : High Fat Diet, Obesity
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Anti-Obesity Agents
[+]

Magnolol attenuates concanavalin A-induced hepatic fibrosis.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Basic Clin Pharmacol Toxicol. 2017 Jun ;120(6):560-570. Epub 2017 Mar 7. PMID: 28032440
Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Hepatitis: Lectin-Induced (concanavalin)
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate.Apr 26, 2020

Pubmed Data : Pharmacol Res. 2020 Apr 27 ;157:104845. Epub 2020 Apr 27. PMID: 32353588
Article Published Date : Apr 26, 2020
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Nrf2 activation
[+]

Mangiferin alleviates renal interstitial fibrosis in streptozotocin-induced diabetic mice.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Diabetes Res. 2020 ;2020:9481720. Epub 2020 Jan 31. PMID: 32076626
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging.Feb 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2021 Mar 1 ;25(2):131-137. PMID: 33602883
Article Published Date : Feb 28, 2021
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Aging: Heart, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Mangiferin attenuates bleomycin-induced pulmonary fibrosis.Mar 06, 2019

Pubmed Data : J Pharm Pharmacol. 2019 Mar 7. Epub 2019 Mar 7. PMID: 30847938
Article Published Date : Mar 06, 2019
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

Melittin possesses potent anti-fibrotic and anti- epithelial-to-mesenchymal transition properties.Apr 12, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxins (Basel). 2017 Apr 13 ;9(4). Epub 2017 Apr 13. PMID: 28406452
Article Published Date : Apr 12, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bee Venom
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

MERTK +/hi M2c macrophages induced by baicalin alleviate non-alcoholic fatty liver disease.Sep 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Sep 30 ;22(19). Epub 2021 Sep 30. PMID: 34638941
Article Published Date : Sep 29, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Mesenchymal Stem Cells Synergize with 635, 532, and 405 nm Laser Wavelengths in Renal Fibrosis.Nov 01, 2016

Pubmed Data : Photomed Laser Surg. 2016 Nov ;34(11):556-563. Epub 2016 May 31. PMID: 27244220
Article Published Date : Nov 01, 2016
Study Type : Animal Study
Additional Links
Diseases : Renal Fibrosis
Therapeutic Actions : Laser Treatment
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Bodily Tissue Regeneration
[+]

Metabolomics reveals the renoprotective effect of n-butanol extract and amygdalin extract from Amygdalus mongolica in rats with renal fibrosis.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Artif Cells Nanomed Biotechnol. 2021 Dec ;49(1):556-564. PMID: 34278886
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Amygdalin (laetrile)
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Modified citrus pectin ameliorates myocardial fibrosis and inflammation.May 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Jun ;126:110071. Epub 2020 Mar 12. PMID: 32172066
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Modified Citrus Pectin
Diseases : Inflammation, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective
[+]

Modified citrus pectin stops progression of liver fibrosis by inhibiting galectin-3.Apr 30, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 May ;94(5):554-62. Epub 2015 Aug 16. PMID: 27010252
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Substances : Modified Citrus Pectin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Superoxide Dismutase Up-regulation
[+]

Myricetin inhibits the activation of hepatic stellate cells and ameliorates carbon tetrachloride induced liver fibrosis in mice.Dec 15, 2016

Pubmed Data : Mol Nutr Food Res. 2016 Dec 16. Epub 2016 Dec 16. PMID: 27983763
Article Published Date : Dec 15, 2016
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Myricetin modulates macrophage polarization and mitigates liver inflammation and fibrosis in a murine model of nonalcoholic steatohepatitis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Med (Lausanne). 2020 ;7:71. Epub 2020 Mar 4. PMID: 32195263
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Myrtle extract effectively inhibited the inflammation and fibrosis of lung parenchyma in both preventive and therapeutic methods.Sep 30, 2018

Pubmed Data : Drug Chem Toxicol. 2018 Oct ;41(4):408-414. Epub 2018 May 11. PMID: 29747538
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Myrtle
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Prophylactic Agents
[+]

N-acetylcysteine prevents bladder tissue fibrosis in a lipopolysaccharide-induced cystitis rat model.May 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 May 31 ;9(1):8134. Epub 2019 May 31. PMID: 31148586
Article Published Date : May 30, 2019
Study Type : Animal Study
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Cystitis, Fibrosis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Fibrotic
[+]

N. Sativa extract is effective for early and late prevention of pulmonary fibrosis and inflammation. Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2018 May-Jun;8(3):263-275. PMID: 29881712
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic
[+]

Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctionsDec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Artif Cells Nanomed Biotechnol. 2018 ;46(sup3):S707-S716. Epub 2018 Oct 4. PMID: 30284484
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, NF-kappaB Inhibitor
[+]

Naringenin attenuates the progression of liver fibrosis via inactivation of hepatic stellate cells and profibrogenic pathways.Oct 12, 2019

Pubmed Data : Eur J Pharmacol. 2019 Oct 13 ;865:172730. Epub 2019 Oct 13. PMID: 31618621
Article Published Date : Oct 12, 2019
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Transforming growth factor beta (TGF-β) inhibitor
[+]

Naringenin prevents carbon tetrachloride induced liver inflammation, necrosis and fibrosis.Jun 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2017 Jun 28 ;23(24):4354-4368. PMID: 28706418
Article Published Date : Jun 27, 2017
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Chemically-Induced Liver Damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective, NF-kappaB Inhibitor
[+]

Naringenin treatment suppressed the inflammatory response and pulmonary fibrosis by inhibition of autophagy after Mycoplasma pneumoniae infection.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2018 ;2018:8753894. Epub 2018 Apr 4. PMID: 29849498
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Fibrosis, Mycoplasma Infections, Pneumonia
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Naringin is a promising therapeutic candidate for hepatic fibrosis.Oct 14, 2017

Pubmed Data : Life Sci. 2017 Oct 15 ;187:50-57. Epub 2017 Aug 19. PMID: 28830755
Article Published Date : Oct 14, 2017
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective, Interleukin-6 Downregulation
[+]

Naringin prevents cyclophosphamide-induced hepatotoxicity.May 13, 2021

Pubmed Data : Food Chem Toxicol. 2021 May 14 ;153:112266. Epub 2021 May 14. PMID: 33992719
Article Published Date : May 13, 2021
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Hepatoprotective
Problem Substances : Cyclophosphamide
[+]

Naturally fermented Noni juice manifests a protective potential on liver fibrosis.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Chin Med Assoc. 2017 Apr ;80(4):212-221. Epub 2017 Mar 6. PMID: 28268174
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Fermented Foods and Beverages, Noni
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Neferine may have antifibrogenic effects in diabetes-related cardiac fibrosis.Sep 19, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Sep 20 ;7(38):61703-61715. PMID: 27533252
Article Published Date : Sep 19, 2016
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Diabetic Complications, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
Additional Keywords : Anti-Fibrotic, Cardioprotective, Diabetic Complications, Lotus, Myocardial Fibrosis
[+]

Neohesperidin inhibits TGF-β1/Smad3 signaling and alleviates bleomycin-induced pulmonary fibrosis in mice.Nov 30, 2019

Pubmed Data : Eur J Pharmacol. 2019 Dec 1 ;864:172712. Epub 2019 Oct 2. PMID: 31586469
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : neohesperidin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Transforming growth factor beta (TGF-β) inhibitor
[+]

Nigella sativa oil treatment attenuated the effects of bleomycin induced pulmonary fibrosis.Apr 12, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr 13 ;90:626-637. Epub 2017 Apr 13. PMID: 28412654
Article Published Date : Apr 12, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Nigella sativa treatment might be beneficial in lung injury and have potential clinical use.Dec 31, 2008

Pubmed Data : Acta Histochem. 2009 ;111(5):393-403. Epub 2009 May 9. PMID: 19428057
Article Published Date : Dec 31, 2008
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Fibrosis, Lung Damage
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
Additional Keywords : Plant Extracts
[+]

Nimbolide ameliorates unilateral ureteral obstruction-induced renal fibrosis.Dec 31, 2018

Pubmed Data : Mol Immunol. 2019 08 ;112:247-255. Epub 2019 Jun 12. PMID: 31202101
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Renoprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Nobiletin might be a novel and promising agent for treatment of NASH and liver fibrosis.Oct 21, 2021

Pubmed Data : J Nutr Biochem. 2021 Oct 22:108888. Epub 2021 Oct 22. PMID: 34695558
Article Published Date : Oct 21, 2021
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective
[+]

Nrf2 Is a key regulator on puerarin preventing cardiac fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:540. Epub 2018 Jun 6. PMID: 29928229
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Oleanolic acid acetate may mitigate the inflammatory response and development of pulmonary fibrosis in the lungs.Mar 01, 2018

Pubmed Data : Respir Physiol Neurobiol. 2018 Mar 2 ;252-253:1-9. Epub 2018 Mar 2. PMID: 29505886
Article Published Date : Mar 01, 2018
Study Type : Animal Study
Additional Links
Substances : Oleanolic acid
Diseases : Fibrosis, Lung Inflammation
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Oligo-fucoidan improves diabetes-induced renal fibrosis. Oct 07, 2020

Pubmed Data : Nutrients. 2020 Oct 8 ;12(10). Epub 2020 Oct 8. PMID: 33049944
Article Published Date : Oct 07, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Oligo-fucoidan prevents renal tubulointerstitial fibrosis by inhibiting the CD44 signal pathway.Jan 17, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 01 18 ;7:40183. Epub 2017 Jan 18. PMID: 28098144
Article Published Date : Jan 17, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Chronic Kidney Disease (CKD), Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Omega-3 polyunsaturated fatty acids reduces liver fibrosis and promotes liver regeneration.Oct 31, 2019

Pubmed Data : Eur Rev Med Pharmacol Sci. 2019 Nov ;23(22):10151-10160. PMID: 31799687
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
Additional Keywords : Liver Regeneration
[+]

Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction.Nov 24, 2019

Pubmed Data : J Nutr Biochem. 2019 Nov 25 ;77:108253. Epub 2019 Nov 25. PMID: 31835147
Article Published Date : Nov 24, 2019
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Cardiovascular Diseases, High Fat Diet
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective
[+]

Oridonin ameliorates carbon tetrachloride-induced liver fibrosis.May 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Dev Res. 2020 Jun ;81(4):526-533. Epub 2020 Mar 26. PMID: 32219880
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Oridonin
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective
[+]

Oridonin inhibits myofibroblast differentiation and bleomycin-induced pulmonary fibrosis.Oct 21, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Oct 22 ;24:7548-7555. Epub 2018 Oct 22. PMID: 30347408
Article Published Date : Oct 21, 2018
Study Type : Animal Study
Additional Links
Substances : Oridonin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Oroxylin A induces apoptosis of activated hepatic stellate cells through endoplasmic reticulum stress.Nov 30, 2019

Pubmed Data : Apoptosis. 2019 Dec ;24(11-12):905-920. PMID: 31538267
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Paeoniflorin attenuates myocardial fibrosis in isoprenaline-induced chronic heart failure.Mar 31, 2020

Pubmed Data : Curr Med Sci. 2020 Apr ;40(2):307-312. Epub 2020 Apr 26. PMID: 32337690
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Heart Failure, Myelofibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Paeoniflorin attenuates pulmonary fibrosis by suppressing type I collagen synthesis.Oct 06, 2013

Pubmed Data : J Ethnopharmacol. 2013 Oct 7 ;149(3):825-32. Epub 2013 Aug 22. PMID: 23973787
Article Published Date : Oct 06, 2013
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents
[+]

Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosisAug 31, 2011

Pubmed Data : Parasitology. 2011 Sep ;138(10):1259-71. Epub 2011 Aug 3. PMID: 21810309
Article Published Date : Aug 31, 2011
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Liver Cirrhosis, Schistosomiasis
Pharmacological Actions : Anti-Fibrotic, interleukin-13 down-regulation
[+]

Paeoniflorin can inhibit the radiation induced hepatic fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2018 ;10(3):1012-1021. Epub 2018 Mar 15. PMID: 29636890
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Chemotherapy and Radiation Toxicity, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Radioprotective
[+]

Paeoniflorin is predicted to be a potential therapy for chronic hepatic diseases associated with fibrosis and angiogenesis.Jan 31, 2019

Pubmed Data : Exp Parasitol. 2019 Feb ;197:85-92. Epub 2018 Nov 8. PMID: 30414842
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Liver Disease, Schistosomiasis
Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic, Vascular Endothelial Growth Factor Inhibitors
[+]

Paeonol delays the progression of diabetic renal fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:512. Epub 2018 May 18. PMID: 29867511
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Nrf2 activation, SIRT1 Activator
[+]

Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model.Jul 31, 2019

Pubmed Data : J Cell Physiol. 2019 Aug ;234(8):14351-14363. Epub 2019 Feb 4. PMID: 30714138
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, MicroRNA modulator
[+]

Palmitoylethanolamide may be a potential new treatment for liver fibrosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:709. Epub 2018 Jul 13. PMID: 30057547
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Palmitoylethanolamide reduces the extent of lung inflammation in a mouse model of idiopathic pulmonary fibrosis.Aug 31, 2016

Pubmed Data : Pharmacol Res. 2016 Sep ;111:405-412. Epub 2016 Jul 8. PMID: 27402190
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents
[+]

Panax notoginseng saponins ameliorates experimental hepatic fibrosis.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Chin Med. 2016 Apr ;36(2):217-24. PMID: 27400477
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Panax Notoginseng
Diseases : Liver Cirrhosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Parthenolide alleviates peritoneal fibrosis.Dec 11, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Immunopharmacol. 2019 Dec 12 ;78:106064. Epub 2019 Dec 12. PMID: 31838448
Article Published Date : Dec 11, 2019
Study Type : Animal Study
Additional Links
Substances : Parthenolide
Diseases : Fibrosis
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Perilla frutescens sprout extract may be useful for the prevention or treatment of diabetic nephropathy.Feb 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Feb 8 ;11(2). Epub 2019 Feb 8. PMID: 30744045
Article Published Date : Feb 07, 2019
Study Type : Animal Study
Additional Links
Substances : Perilla
Diseases : Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Piceatannol may be a beneficial therapeutic agent for treating renal fibrosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(11):e0167340. Epub 2016 Nov 30. PMID: 27902771
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Piceatannol
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Pinocembrin ameliorates skin fibrosis via inhibiting TGF-β1 signaling pathway. Jan 18, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomolecules. 2021 08 19 ;11(8). Epub 2021 Aug 19. PMID: 34439906
Article Published Date : Jan 18, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Fibrosis, Keloid
Pharmacological Actions : Anti-Fibrotic, Transforming growth factor beta (TGF-β) inhibitor
[+]

Piperine attenuated cardiac fibrosis in mice.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EBioMedicine. 2017 Apr ;18:179-187. Epub 2017 Mar 14. PMID: 28330809
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis.Nov 14, 2021

Pubmed Data : Food Funct. 2021 Nov 15 ;12(22):11686-11703. Epub 2021 Nov 15. PMID: 34730139
Article Published Date : Nov 14, 2021
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective, Nrf2 activation, Transforming growth factor beta (TGF-β) inhibitor
[+]

Piperlongumine attenuates angiotensin-II-induced cardiac hypertrophy and fibrosis.Jan 31, 2021

Pubmed Data : Phytomedicine. 2021 Feb ;82:153461. Epub 2021 Jan 6. PMID: 33497927
Article Published Date : Jan 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Cardiac Hypertrophy, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Piperlongumine attenuates bile duct ligation-induced liver fibrosis.Oct 31, 2020

Pubmed Data : Int Immunopharmacol. 2020 Nov ;88:106909. Epub 2020 Sep 1. PMID: 32882664
Article Published Date : Oct 31, 2020
Study Type : Animal Study
Additional Links
Substances : Piperlongumine
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective
[+]

Polyporus umbellatus protects against renal fibrosis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:633566. Epub 2021 Feb 19. PMID: 33679418
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Medicinal Mushrooms
Diseases : Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Renoprotective
[+]

Pomegranate juice extract ameliorated polycystic ovary syndrome accompanying endometrial histological alterations.May 18, 2021

Pubmed Data : Morphologie. 2021 May 19. Epub 2021 May 19. PMID: 34023214
Article Published Date : May 18, 2021
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Antiproliferative
[+]

Pomegranate seed oil decreased obesity-mediated insulin resistance and the progression of hepatic fibrosis.Jul 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Jul 31 ;21(15). Epub 2020 Jul 31. PMID: 32751794
Article Published Date : Jul 30, 2020
Study Type : Animal Study
Additional Links
Substances : Pomegranate Seed
Diseases : Hepatic Steatosis, Liver Fibrosis, Obesity
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective
[+]

PPARα-dependent effects of palmitoylethanolamide against retinal neovascularization and fibrosis.Jan 08, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Invest Ophthalmol Vis Sci. 2020 04 9 ;61(4):15. PMID: 32298438
Article Published Date : Jan 08, 2020
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Macular Degeneration, Retinal Diseases, Retinopathy: Hyperoxia-induced
Pharmacological Actions : Anti-Fibrotic
[+]

Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by paeonol.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2017 ;8:193. Epub 2017 Mar 31. PMID: 28408888
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants
[+]

Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosisAug 14, 2018

Pubmed Data : Eur J Pharmacol. 2018 Aug 15 ;833:545-554. Epub 2018 Jun 18. PMID: 29913124
Article Published Date : Aug 14, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Cardioprotective
[+]

Probiotic Lactobacillus rhamnosus GG prevents liver fibrosis through inhibiting hepatic bile acid synthesis and enhancing bile acid excretion.Sep 29, 2019

Pubmed Data : Hepatology. 2019 Sep 30. Epub 2019 Sep 30. PMID: 31571251
Article Published Date : Sep 29, 2019
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus GG, Probiotics
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

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