Anti-Fibrotic

Name	AC	CK
Curcumin	16	24
Resveratrol	3	4
Ashwagandha	1	2
Astragalus	1	2
Bacopa	1	2
Berberine	1	2
Camel Milk	1	2
Dandelion	1	2
Green Tea	1	2
Honey	1	2
Licorice	1	2
Loquat Seeds	1	2
Mangiferin	1	2
Milk Thistle	1	2
Protandim	1	2
Red Sage	1	2
Salacia oblonga	1	2
Taurine	1	2
Turmeric	1	2
EGCG (Epigallocatechin gallate)	1	1
Phellinus Linteus	1	1
Stilbenes	1	1

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Tanshinone IIA can effectively improve liver fibrosis and liver function.Dec 31, 2018

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Pubmed Data : Int J Food Sci Nutr. 2016 Jun ;67(4):461-9. Epub 2016 Mar 17. PMID: 26983396

Article Published Date : May 31, 2016

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2017 Mar 21 ;97(11):869-873. PMID: 28355745

Article Published Date : Mar 20, 2017

Study Type : Human In Vitro

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Substances : Cinnamaldehyde

Diseases : Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic

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Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways.Feb 01, 2019

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Pubmed Data : Chem Biol Interact. 2019 Feb 1 ;299:131-139. Epub 2018 Dec 11. PMID: 30543783

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Pubmed Data : Med Gas Res. 2016 Jul-Sep;6(3):177-179. Epub 2016 Oct 14. PMID: 27867488

Article Published Date : Jun 30, 2016

Study Type : Human: Case Report

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Substances : Hydrogen Water

Diseases : Graft vs Host Disease

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants

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Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.Oct 09, 2019

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Pubmed Data : J Biochem Mol Toxicol. 2020 Mar 15:e22492. Epub 2020 Mar 15. PMID: 32173980

Article Published Date : Mar 14, 2020

Study Type : Animal Study

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Substances : Resveratrol

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Antioxidants, Cardioprotective, Chemoprotective Agents

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Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

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Pubmed Data : World J Gastroenterol. 2006 Nov 14 ;12(42):6835-41. PMID: 17106933

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Pubmed Data : SAGE Open Med. 2019 ;7:2050312119828260. Epub 2019 Feb 4. PMID: 30783524

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Vitamin C

Diseases : Fibrosis, Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

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Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

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Pubmed Data : Biomed Pharmacother. 2017 May ;89:1297-1309. Epub 2017 Mar 17. PMID: 28320097

Article Published Date : Apr 30, 2017

Study Type : Animal Study

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Substances : Gotu Kola

Diseases : Chemotherapy-Induced Toxicity: Bleomycin, Inflammation

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

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Astragaloside IV attenuates renal fibrosis through repressing epithelial-to-mesenchymal transition.Dec 31, 2018

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Pubmed Data : Phytomedicine. 2017 Jul 1 ;30:10-17. Epub 2017 Apr 19. PMID: 28545665

Article Published Date : Jun 30, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Astragaloside

Diseases : Hypoxia, Myocardial Fibrosis

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

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Astragalus saponins and glycyrrhizic acid synergistically alleviated hepatic fibrosis.Jun 05, 2016

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Pubmed Data : Front Immunol. 2019 ;10:1257. Epub 2019 Jun 11. PMID: 31244833

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Betulinic acid

Diseases : Chagas Disease, Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Cardioprotective, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Biochanin-A ameliorates pulmonary fibrosis.Jul 31, 2020

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Pubmed Data : Can J Gastroenterol Hepatol. 2019 ;2019:5236149. Epub 2019 Nov 22. PMID: 31886154

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Blueberry

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Gastrointestinal Agents, Gastroprotective, Hepatoprotective

Additional Keywords : Gut-liver axis

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Both rosemary extracts administrated alone or in combination alleviated synergistically lung fibrosis.Oct 15, 2020

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Pubmed Data : Nutr Cancer. 2020 Oct 16:1-12. Epub 2020 Oct 16. PMID: 33059466

Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis.Jan 31, 2020

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Pubmed Data : Phytomedicine. 2020 Feb ;67:153160. Epub 2019 Dec 26. PMID: 31901889

Article Published Date : Jan 31, 2020

Study Type : Animal Study

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Substances : Celastrol

Diseases : Fibrosis, Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

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Chamomile hydroalcoholic extract may be able to diminish the toxic effects of bleomycin on the lung tissues.Sep 30, 2018

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Pubmed Data : J Zhejiang Univ Sci B. 2011 Dec ;12(12):1024-33. PMID: 22135152

Pharmacological Actions : Anti-Fibrotic, Cardioprotective

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Emodin ameliorates renal damage and podocyte injury in a model of diabetic nephropathy.Dec 31, 2020

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Pubmed Data : Diabetes Metab Syndr Obes. 2021 ;14:1253-1266. Epub 2021 Mar 18. PMID: 33776462

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Emodin

Diseases : Diabetic Nephropathy, Kidney Fibrosis

Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Renoprotective

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Emodin ameliorates tubulointerstitial fibrosis in obstructed kidneys by inhibiting EZH2.Dec 31, 2020

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Pubmed Data : Front Pharmacol. 2020 ;11:553690. Epub 2020 Dec 14. PMID: 33381023

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Fisetin

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

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Fisetin alleviates atrial inflammation, remodelling, and vulnerability to atrial fibrillation after myocardial infarction.Nov 29, 2019

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High-fat diet-induced metabolic syndrome and oxidative stress in obese rats are ameliorated by yogurt supplementation.Dec 26, 2019

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Pubmed Data : J Photochem Photobiol B. 2020 Jan ;203:111731. Epub 2019 Dec 4. PMID: 31935633

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Diseases : Lung Inflammation, Pulmonary Fibrosis

Therapeutic Actions : Laser Treatment: Low-Level

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents

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Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis.Dec 31, 2018

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Pubmed Data : Am J Transl Res. 2019 ;11(4):2590-2602. Epub 2019 Apr 15. PMID: 31105865

Article Published Date : Dec 31, 2018

Study Type : Animal Study

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Substances : Fucoidan

Diseases : Pulmonary Fibrosis: Bleomycin-Induced

Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents

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Lung injury induced by bisphenol A is ameliorated by selenium supplementation.Feb 11, 2017

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Pubmed Data : Pathophysiology. 2017 Feb 12. Epub 2017 Feb 12. PMID: 28285737

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Pubmed Data : J Agric Food Chem. 2010 Nov 24 ;58(22):11653-61. Epub 2010 Oct 19. PMID: 20958047

Article Published Date : Nov 23, 2010

Study Type : Animal Study, In Vitro Study

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Substances : Luteolin

Diseases : Fibrosis

Pharmacological Actions : Anti-Fibrotic, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

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Magnolol attenuates concanavalin A-induced hepatic fibrosis.May 31, 2017

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Pubmed Data : Photomed Laser Surg. 2016 Nov ;34(11):556-563. Epub 2016 May 31. PMID: 27244220

Article Published Date : Nov 01, 2016

Study Type : Animal Study

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Diseases : Renal Fibrosis

Therapeutic Actions : Laser Treatment

Pharmacological Actions : Anti-Fibrotic

Additional Keywords : Bodily Tissue Regeneration

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Modified citrus pectin ameliorates myocardial fibrosis and inflammation.May 31, 2020

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Pubmed Data : Oncotarget. 2016 Sep 20 ;7(38):61703-61715. PMID: 27533252

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2019 Nov ;23(22):10151-10160. PMID: 31799687

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Pubmed Data : Exp Parasitol. 2019 Feb ;197:85-92. Epub 2018 Nov 8. PMID: 30414842

Article Published Date : Jan 31, 2019

Study Type : Animal Study

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Substances : Paeoniflorin

Diseases : Liver Disease, Schistosomiasis

Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic, Vascular Endothelial Growth Factor Inhibitors

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Paeonol delays the progression of diabetic renal fibrosis.Dec 31, 2017

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Pomegranate seed oil decreased obesity-mediated insulin resistance and the progression of hepatic fibrosis.Jul 30, 2020

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Pubmed Data : Int J Mol Sci. 2020 Jul 31 ;21(15). Epub 2020 Jul 31. PMID: 32751794

Article Published Date : Jul 30, 2020

Study Type : Animal Study

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Substances : Pomegranate Seed

Diseases : Hepatic Steatosis, Liver Fibrosis, Obesity

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective

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Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by paeonol.Dec 31, 2016

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Pubmed Data : Ren Fail. 2017 Nov ;39(1):423-431. PMID: 28335679

Article Published Date : Oct 31, 2017

Study Type : Animal Study

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Substances : Puerarin

Diseases : Kidney Fibrosis

Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Antioxidants, Renoprotective

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Puerarin could be a potential agent in attenuating myocardial Infarction induced cardiac fibrosis.Dec 31, 2015

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 Jun ;43(12):2618-2623. PMID: 29950085

Article Published Date : May 31, 2018

Study Type : Animal Study

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Substances : Puerarin

Diseases : Fibrosis, Hypertension: Pulmonary, Hypoxia

Pharmacological Actions : Anti-Fibrotic

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Puerarin may provide a new adjuvant for antifibrotic treatment strategies for patients with heart disease.Dec 31, 2016

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Pubmed Data : Chin J Integr Med. 2006 Sep;12(3):207-11. PMID: 17005083

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Renoprotective

Additional Keywords : Plant Extracts

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Rosmarinic acid could impede the progression of liver fibrosis.Apr 30, 2017

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Pubmed Data : Asian Pac J Trop Med. 2017 May ;10(5):444-453. Epub 2017 May 17. PMID: 28647181

Spirulina liquid extract protects against fibrosis related to non-alcoholic steatohepatitis.Jan 17, 2019

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Pubmed Data : Nutrients. 2019 Jan 18 ;11(1). Epub 2019 Jan 18. PMID: 30669332

Article Published Date : Jan 17, 2019

Study Type : Animal Study

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Substances : Spirulina

Diseases : Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Anti Therapeutic Actions : Western Diet

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Strawberry juice possessed antioxidant, anti-apoptotic and anti-fibrotic properties.Dec 31, 2015

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Pubmed Data : Front Pharmacol. 2020 ;11:218. Epub 2020 Mar 18. PMID: 32256346

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Cranberry

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Nrf2 activation, Transforming growth factor beta (TGF-β) inhibitor

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The protective effect of tanshinone IIA suppresses fibrosis in a rat model of cirrhosis.Mar 31, 2016

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Pubmed Data : J Ethnopharmacol. 2017 Feb 23 ;198:432-443. Epub 2017 Jan 20. PMID: 28111218

Article Published Date : Feb 22, 2017

Study Type : Animal Study

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Substances : Betanin, Prickly Pear Cactus

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Fibrotic, Renoprotective

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The results of the present study may provide a potential therapeutic strategy for liver fibrosis.Dec 31, 2020

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Pubmed Data : Exp Ther Med. 2021 Jan ;21(1):28. Epub 2020 Nov 10. PMID: 33262814

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Shikonin

Diseases : Liver Fibrosis

Pharmacological Actions : Anti-Fibrotic, Hepatoprotective

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View the Evidence: 462 Abstracts with Anti-Fibrotic Research

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Tanshinone IIA can effectively improve liver fibrosis and liver function.Dec 31, 2018

This study determines the positive efficacy of vitamin D supplementation for chronic liver disease.Apr 30, 2020

Apigenin could be an attractive therapeutic potential for the treatment of renal fibrosis.Mar 20, 2020

Evaluation of efficacy of curcumin along with lycopene and piperine in the management of oral submucous fibrosis.Jun 30, 2019

Flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.May 31, 2016

Korean Red Ginseng could be used as a complementary therapy for chronic hepatitis B.Nov 30, 2016

Silymarin may reduce liver fibrosis.Apr 14, 2017

There was less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10.Dec 07, 2017

Treatment with lycopene led to improvement in the symptoms of oral submucous fibrosis in the present study.Jul 10, 2020

Astaxanthin may be useful as a preventive/therapeutic agent for cardiac dysfunction and myocardial fibrosis.Mar 11, 2017

Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21.Jan 01, 2018

Chebulagic acid and Chebulinic acid inhibit TGF-β1 induced fibrotic changes in the chorio-retinal endothelial cells by inhibiting ERK phosphorylation.Jan 01, 2019

Cinnamaldehyde may be able to slow down the progression of cardiac fibrosis.Mar 20, 2017

Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways.Feb 01, 2019

Photobiomodulation therapy enhances the anti-fibrotic activity of adipose-derived mesenchymal stem cells.Feb 01, 2019

Prunella vulgaris attenuates diabetic renal injury.Mar 29, 2017

Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells.Nov 04, 2020

Schisanhenol may be a potential anti-liver fibrosis drug.Mar 19, 2020

The antifibrotic effect of quercetin can be enhanced by adding methyl group on functionally important position.Dec 01, 2019

Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease.Jun 30, 2016

Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats.Oct 09, 2019

Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β.Jun 10, 2020

Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation.Nov 29, 2020

A multi-herbal product called Protandim prevents fibrosis and capillary loss and preserves right ventricular function in rats.Nov 17, 2009

A. vera supplementation protects against development of cardiac inflammation, fibrosis, and oxidative stress in isoprenaline-administered rats.Aug 31, 2019

Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.Mar 01, 2017

Active components from Sea Buckthorn regulate hepatic stellate cell activation and liver fibrogenesis.Nov 20, 2018

Active vitamin D impedes the progression of non-alcoholic fatty liver disease.Dec 02, 2019

Administration of thymoquinone reduced renal fibrosis and permeability and improved oxidative stress status.Nov 30, 2017

Allicin has the potential to help in the treatment of diabetic nephropathy.Nov 14, 2020

Allyl isothiocyanate reduces liver fibrosis by regulating Kupffer cell activation.Jun 05, 2018

Amygdalin improves microcirculatory disturbance and attenuates pancreatic fibrosis.Nov 08, 2017

ANG II-AT1 receptor pathway is involved in the anti-fibrotic effect of beta-elemene.Mar 31, 2009

Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-β/AKT/mTOR signaling pathway.Mar 12, 2020

Anti-fibrotic actions of roselle extract in rat model of myocardial infarction.Aug 19, 2018

Anti-fibrotic effects of curcumin and some of its analogues in the heart.Sep 10, 2019

Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats.May 31, 2014

Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.Apr 30, 2018

Antifibrotic effects of gallic acid on hepatic stellate cells.Dec 31, 2018

Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis.Aug 20, 2018

Antioxidant, anti-inflammatory and anti-fibrotic effects of Boswellia serrate gum resin in CCl4-induced hepatotoxicityJan 31, 2020

Antioxidant, antiapoptotic, and antifibrotic effects of the combination of liposomal resveratrol and carvedilol against doxorubicin-induced cardiomyopathy.Mar 14, 2020

Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.Nov 13, 2006

Arctigenin could protect the kidney from unilateral ureteral obstruction induced injury and fibrogenesis.Jun 30, 2017

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway.Dec 31, 2018

Ascorbic acid attenuated the inflammatory response and fibrosis in the lungs of rats treated with lipopolysaccharide.Dec 31, 2018

Asiatic acid and naringenin may represent as a novel and effective therapy for chronic kidney disease associated with fibrosis.Nov 09, 2015

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Asiatic acid inhibits lliver fibrosis.Dec 31, 2011

Asiatic acid might be an effective candidate for pulmonary fibrosis and inflammation treatment.Apr 30, 2017

Asiaticoside attenuates bleomycin-induced pulmonary fibrosis.Jun 29, 2020

Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.Feb 18, 2019

Astaxanthin and vitamin E effectively improved hepatic gene expression.Mar 07, 2017

Astaxanthin given in the post injury period significantly decreases fibrosis.Nov 10, 2019

Astaxanthin had a significant protective effect on liver fibrosis by suppressing multiple pro-fibrogenic factors.Dec 31, 2013

Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue.Mar 01, 2016

Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment.Jun 02, 2019

Astragaloside inhibits hepatic fibrosis by modulation of TGF-β1/Smad signalling pathway.Dec 31, 2017

Astragaloside IV attenuates renal fibrosis through repressing epithelial-to-mesenchymal transition.Dec 31, 2018

Astragaloside IV improves bleomycin-induced pulmonary fibrosis.Dec 31, 2016

Astragaloside IV improves renal function and fibrosis.Dec 31, 2017

Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway.Nov 14, 2019

Astragaloside IV inhibits excessive mesangial cell proliferation and renal fibrosis caused by diabetic nephropathy.Sep 30, 2019

Astragaloside IV modulates TGF‐β1‐dependent epithelial‐mesenchymal transition in bleomycin‐induced pulmonary fibrosisAug 31, 2018

AstragalosideⅣ was beneficial against cardiac fibrosis.Jun 30, 2017

Astragalus saponins and glycyrrhizic acid synergistically alleviated hepatic fibrosis.Jun 05, 2016

Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat.Dec 31, 2017

Berberine alleviates adipose tissue fibrosis.May 27, 2018

Berberine can ameliorate tubulointerstitial fibrosis in diabetic nephropathy.Dec 31, 2015

Beta-sitosterol can be used to attenuate pulmonary fibrosis through suppression of EMT by inhibiting the TGF-β1/Snail pathway.Sep 03, 2019

Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.Dec 31, 2020

Betulinic acid derivative BA5 had a potent anti-inflammatory activity on a model of parasite-driven heart disease.Dec 31, 2018

Anti-Fibrotic

View the Evidence:
462 Abstracts with Anti-Fibrotic Research