Anti-Glycation Agents

Name	AC	CK
Vitamin C	3	22
Flavonoids	14	21
Curcumin	3	16
Pomegranate	3	13
Blueberry	2	11
Grape	2	11
Lemon Balm	2	11
Vitamin D	2	11
Benfotiamine	1	10
Omega-3 Fatty Acids	1	10
Phytate	1	10
Polyphenols	8	9
EGCG (Epigallocatechin gallate)	4	6
Plantago asiatica	1	5
Rutin	3	5
Bael	2	4
Dill	2	4
Eugenol	2	4
Garlic	3	4
Lychee	2	4
Quercetin	2	4
Berberine	2	3
Carnosic Acid	2	3
Chrysin	2	3
Cranberry	3	3
Fenugreek	1	3
Fermented Foods and Beverages	2	3
Genistein	2	3
Gingerol	2	3
Mangosteen	3	3
Mulberry	2	3
Phloretin	2	3
Rosmarinic acid	2	3
Sea buckthorn	2	3
Vanillin	2	3
6-Shogaol	2	2
Allicin	1	2
Bacopa	1	2
Banana	1	2
Banana Leaf	1	2
Basil	1	2
Bitter Melon	2	2
Buckwheat	1	2
Citric Acid	1	2
Coriandrum sativum	1	2
Cumin	1	2
Dandelion	2	2
Dogwood	1	2
Eucalyptus	1	2
Ginger	2	2
Ginkgo biloba	1	2
Grapefruit peel extract	1	2
Green Tea	1	2
Hesperidin	1	2
Hu Zhang (Polygonum cuspidatum)	1	2
Jambul	1	2
Kombucha Tea	1	2
Lactobacillus fermentum	1	2
Lycopene	1	2
Myricetin	1	2
Naringenin	2	2
Oligosaccharides	2	2
Persimmon	1	2
Pterostilbene	1	2
Rooibos	1	2
Rose Hips	1	2
Rosemaric Acid	1	2
Seaweed: Brown	2	2
Spirulina	1	2
Star Anise (Illicium anisatum)	1	2
Taurine	1	2
Vitamin E	1	2
Xanthohumol	1	2
Zinc	1	2
Aloe Vera	1	1
Anthocyanins	1	1
Apple	1	1
Apple Polyphenols	1	1
Babchi	1	1
Bee Propolis	1	1
Black Pepper	1	1
Black Raspberry	1	1
Blackberry	1	1
Blue-Green Algae	1	1
Boerhaavia diffusa	1	1
Broccoli	1	1
Broccoli Sprouts	1	1
Brussel sprouts	1	1
Butterfly Pea	1	1
Cabbage	1	1
Cayenne	1	1
Chokeberry	1	1
Cocoa	1	1
Corn Silk	1	1
Cruciferous Vegetables	1	1
Daisy	1	1
Ellagic Acid	1	1
Emodin	1	1
Eriodictyol	1	1
Feijoa	1	1
Hawthorn	1	1
Homeopathic Medicine: All	1	1
Kaempferia parviflora	1	1
Licorice	1	1
Luteolin	1	1
Mangiferin	1	1
Maple Syrup	1	1
Moringa oleifera	1	1
Nordihydroguaiaretic acid (NDGA)	1	1
Olive leaf extract	1	1
Organosulfur Compounds	1	1
Parsley	1	1
Passion Flower	1	1
Peanut	1	1
Peppermint	1	1
Phlorotannins	1	1
Piceatannol	1	1
Plantago	1	1
Propolis: Bee	1	1
Puerarin	1	1
Raspberry	1	1
Reishi Mushroom	1	1
Rock-rose	1	1
Rosemary	1	1
Sesamin	1	1
Silibinin	1	1
Soursop	1	1
Strawberry	1	1
Sulforaphane	1	1
Tamarind	1	1
Terminalia chebula	1	1
Theanine	1	1
Thymoquinone	1	1
Turmeric	1	1
Urolithin A	1	1
Vegetables: All	1	1
White Tea	1	1
Xanthones	1	1

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Lemon balm has the potential to provide health benefits with regard to glycation-associated tissue damage in blood vessels and skin of healthy adults.Dec 31, 2016

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Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2017 ;63(1):59-68. PMID: 28367927

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Pubmed Data : Diabetol Metab Syndr. 2019 ;11:86. Epub 2019 Oct 26. PMID: 31673295

Article Published Date : Dec 31, 2018

Study Type : Human Study

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Substances : Vitamin D

Diseases : Advanced Glycation End products (AGE), Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Glycation Agents, Anti-Inflammatory Agents, MicroRNA modulator, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Curcumin significantly inhibited the formation of advanced glycation end products (AGEs). Dec 27, 2015

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Aspalathin and other rooibos flavonoids trapped α-dicarbonyls and inhibited formation of advanced glycation end products.Nov 24, 2022

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Pubmed Data : Int J Mol Sci. 2022 Nov 25 ;23(23). Epub 2022 Nov 25. PMID: 36499065

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Pubmed Data : Biochem Biophys Res Commun. 2010 Feb 26 ;393(1):118-22. Epub 2010 Feb 1. PMID: 20117096

Article Published Date : Feb 25, 2010

Study Type : Animal Study

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Substances : Citric Acid

Diseases : Diabetes: Cataract, Diabetes Mellitus: Type 1, Ketosis: Diabetic, Proteinuria

Pharmacological Actions : Anti-Glycation Agents

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Combinations of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress.Jun 25, 2015

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Pubmed Data : J Nutr. 2021 Jun 5. Epub 2021 Jun 5. PMID: 34091674

Article Published Date : Jun 04, 2021

Study Type : Animal Study

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Substances : Quercetin

Diseases : Advanced Glycation End products (AGE)

Pharmacological Actions : Anti-Glycation Agents

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Dill can be recommended as herbal medicine for the control and prevention of diabetic complications.Jun 30, 2016

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Pubmed Data : Biochem Pharmacol. 2015 Feb 15 ;93(4):496-505. Epub 2014 Oct 22. PMID: 25450667

Article Published Date : Feb 14, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Myricetin

Diseases : Advanced Glycation End products (AGE), Diabetic Retinopathy

Pharmacological Actions : Anti-Glycation Agents

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Oligonol attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic mice.Jan 31, 2015

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Pubmed Data : Drug Discov Ther. 2015 Feb ;9(1):13-22. PMID: 25788048

Article Published Date : Jan 31, 2015

Study Type : Animal Study

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Substances : Lychee

Diseases : Advanced Glycation End products (AGE), Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Apoptotic, Anti-Glycation Agents, Renoprotective

Additional Keywords : Advanced Glycation End products (AGE), Diabetes mellitus: Type 2, Gene Expression Regulation, Lychee

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Pomegranate is promising in development a functional biomolecule in treatment and protection against diabetic complications as nephropathy.Oct 02, 2022

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Pubmed Data : Environ Sci Pollut Res Int. 2022 Oct 3. Epub 2022 Oct 3. PMID: 36190633

Article Published Date : Oct 02, 2022

Study Type : Animal Study

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Substances : Flavonoids, Pomegranate

Diseases : Diabetic Nephropathy

Pharmacological Actions : Anti-Glycation Agents, Anti-Inflammatory Agents, Antioxidants

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Prevention of advanced glycation end-products formation in diabetic rats through beta-cell modulation by Aegle marmelos.Apr 20, 2017

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Pubmed Data : BMC Complement Altern Med. 2017 Apr 21 ;17(1):227. Epub 2017 Apr 21. PMID: 28431540

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Pubmed Data : Food Funct. 2018 Jan 26. Epub 2018 Jan 26. PMID: 29372208

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Pubmed Data : Food Funct. 2017 Oct 25. Epub 2017 Oct 25. PMID: 29068027

Article Published Date : Oct 24, 2017

Study Type : Animal Study

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Substances : Taurine

Diseases : Advanced Glycation Endproduct (AGE) Formation, Diabetes: Cognitive Dysfunction

Pharmacological Actions : Anti-Apoptotic, Anti-Glycation Agents, Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents

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These results propose eugenol has dual mode of action in combating diabetes.Jan 06, 2016

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Pubmed Data : Food Res Int. 2021 Jul ;145:110383. Epub 2021 May 5. PMID: 34112386

Article Published Date : Jun 30, 2021

Study Type : Review

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Substances : Polyphenols

Diseases : Insulin Resistance, Metabolic Diseases

Pharmacological Actions : Anti-Glycation Agents, Antioxidants, Hypoglycemic Agents, Insulin Sensitizers

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Antidiabetic, antiglycation, and antioxidant activities of ethanolic seed extract of Passiflora edulis and piceatannolJun 23, 2022

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Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:9823141. Epub 2018 Aug 8. PMID: 30174716

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Pubmed Data : Crit Rev Food Sci Nutr. 2023 May 24:1-19. Epub 2023 May 24. PMID: 37222572

Article Published Date : May 23, 2023

Study Type : Review

Additional Links

Substances : Polyphenols

Diseases : Advanced Glycation End products (AGE), Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Glycation Agents, Anti-Inflammatory Agents, Antioxidants

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Corn silk a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities.Jan 31, 2019

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Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:510-517. Epub 2018 Dec 7. PMID: 30530231

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Pubmed Data : J Mol Recognit. 2019 Oct 21:e2814. Epub 2019 Oct 21. PMID: 31637788

Article Published Date : Oct 20, 2019

Study Type : In Vitro Study

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Substances : Eriodictyol, Naringenin

Diseases : Advanced Glycation End products (AGE)

Pharmacological Actions : Anti-Glycation Agents

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Evaluation of crocin content and in vitro antioxidant and anti-glycation activity of different saffron extracts.Oct 17, 2023

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Mangiferin enhanced the function of Glo-1 under high glucose condition by inducing activation of Nrf2/ARE signaling pathway.Jun 17, 2016

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Pubmed Data : Mol Neurobiol. 2016 Jun 18. Epub 2016 Jun 18. PMID: 27318675

Article Published Date : Jun 17, 2016

Study Type : In Vitro Study

Additional Links

Substances : Mangiferin

Diseases : Advanced Glycation End products (AGE), Diabetic Complications, High Sugar Diet

Pharmacological Actions : Anti-Glycation Agents, Neuroprotective Agents, Nrf2 activation

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Momordica charantia extracts possess high antioxidant and antiglycation activities and are equally good sources of antioxidant and antiglycating agents.Jun 30, 2015

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Pubmed Data : Pak J Pharm Sci. 2015 Jul ;28(4):1217-23. PMID: 26142512

Article Published Date : Jun 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Bitter Melon

Diseases : Advanced Glycation End products (AGE)

Pharmacological Actions : Anti-Glycation Agents, Antioxidants, Chelating Agents

Additional Keywords : Plant Extracts

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Moringa oleifera aqueous leaf extract may delay or prevent AGE-related diabetic complications.Dec 31, 2015

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Pubmed Data : Springerplus. 2016 ;5(1):1098. Epub 2016 Jul 16. PMID: 27468399

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Pubmed Data : Food Chem. 2017 Apr 15 ;221:1057-1061. Epub 2016 Nov 11. PMID: 27979058

The results showed that Clitoria ternatea extract has strong antiglycation and antioxidant properties.Feb 17, 2015

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View the Evidence: 152 Abstracts with Anti-Glycation Agents Research

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A citrus and pomegranate complex reduces methylglyoxal in healthy elderly subjects.Aug 23, 2023

AGE restriction may preserve native defences and insulin sensitivity by maintaining lower basal oxidative stress.Jun 30, 2011

Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy.Dec 31, 2011

Effect of Curcuma longa on glycemia, neuropathic sensation and advanced glycation end product in diabetic patients.Apr 30, 2022

Lemon balm has the potential to provide health benefits with regard to glycation-associated tissue damage in blood vessels and skin of healthy adults.Dec 31, 2016

Omega-3 fatty acid supplementation among diabetic nephropathy patients had favourable effects on AGEs and the receptor for AGEs.Jun 30, 2016

Phytate decreases formation of advanced glycation end-products in patients with type 2 diabetes.Jun 24, 2018

Plasma protein-bound advanced glycation end products can be reduced partly by Vaccinium Myrtillus extract supplement.May 31, 2019

Reduction in circulating AGEs by Mediterranean diet is associated with increased likelihood of type 2 diabetes remission.Dec 31, 2020

Regular intake of grapes may improve eye health.Sep 18, 2023

The daily consumption of a high dose of vitamin C for 8 weeks resulted in enhanced anti-senescence and anti-atherosclerotic effects via an improvement of lipoprotein parameters.Sep 02, 2015

Vitamin C supplementation lowers advanced glycation end products and malondialdehyde in patients with type 2 diabetes.Sep 30, 2023

Vitamin D supplementation could ameliorate AGEs–RAGE signaling pathway in T2DM patients.Dec 31, 2018

Curcumin significantly inhibited the formation of advanced glycation end products (AGEs). Dec 27, 2015

Plantamajoside inhibits UVB and advanced glycation end products-induced MMP-1 expression.Dec 31, 2015

Baicalin ameliorates insulin resistance and regulates hepatic glucose metabolism.Jan 31, 2024

Fenugreek seed ethanolic extract inhibited formation of advanced glycation end products.May 31, 2023

A hot-water extract of rose hip exerted an anti-prediabetic effect in a rat model.Feb 08, 2017

Aegle marmelos Correa leaf extract prevents secondary complications in streptozotocin-induced diabetic rats.May 31, 2013

Allicin alleviates diabetes mellitus by inhibiting the formation of advanced glycation end products.Dec 11, 2022

Anti-glycation properties of Illicium verum Hook.Mar 18, 2022

Anti-glycation properties of zinc-enriched Arthrospira platensis (Spirulina) contribute to prevention of metaflammation in a diet-induced obese.Feb 16, 2024

Antidiabetic cataract effects of Ginkgo biloba extract, rutin and quercetin are mediated by the inhibition of oxidative stress and polyol pathway.Dec 27, 2017

Antidiabetic effects of Syzygium cumini leaves.Oct 27, 2020

Aspalathin and other rooibos flavonoids trapped α-dicarbonyls and inhibited formation of advanced glycation end products.Nov 24, 2022

B. monnieri and its isolate stigmasterol might inhibit the progression of diabetic nephropathy.Sep 30, 2016

Berberine exhibited renoprotective effects in diabetic nephropathy.Jan 09, 2017

Capability of polygonum cuspidatum extract in inhibiting AGEs and preventing diabetes.May 31, 2019

Citric acid ameliorates ketosis and protects against the development of diabetic complications in an animal model of type 1 diabetes.Feb 25, 2010

Combinations of natural anti-oxidants prevents metabolic syndrome by reducing oxidative stress.Jun 25, 2015

Compounds from cumin were found to have antiglycative effects greater than aminoguanidine, a synthetic antiglycative agent.Nov 24, 2015

Coriandrum sativum seeds extract mitigate progression of diabetic nephropathy.Dec 31, 2018

Dietary quercetin reduces plasma and tissue methylglyoxal and advanced glycation end products.Jun 04, 2021

Dill can be recommended as herbal medicine for the control and prevention of diabetic complications.Jun 30, 2016

Dill with potential antioxidant, antiglycation, and hepatoprotective effects can be suggested for treatment of diabetes complications.Dec 31, 2016

EGCG has the potential to help control hyperglycemia, reduce weight, and alleviate diabetes complications.Dec 28, 2016

Ethanol extract from the leaves of Diospyros kaki may be a potential therapeutic strategy for preventing and treating age-related neurodegenerative diseases.Dec 31, 2017

Eucalyptol may be a potent agent antagonizing diabetes-associated malformation of interpodocyte slit junction and podocyte actin cytoskeleton.Jan 09, 2018

Extract ethanol of basil leaves showed good results in lowering blood glucose and advanced glycation end products in diabetes. May 14, 2019

Far-infrared irradiation protects the vascular endothelium in diabetic mice from AGE-induced injury.Jan 09, 2017

Flavonoids derived from buckwheat hull can break advanced glycation end-products and improve diabetic nephropathy.Jun 24, 2021

Fruit pericarp extract of Litchi chinensis was found to delay the progression of diabetic cataractogenesis and retinopathy.Feb 28, 2017

Hesperetin and its derivatives are good candidates for the prevention of presbyopia and cataracts.Apr 30, 2023

Hesperidin reverses perivascular adipose-mediated aortic stiffness with aging.Aug 01, 2017

Hippophae rhamnoides L. leaf extracts alleviate diabetic nephropathy via attenuation of advanced glycation end product-induced oxidative stress.Sep 18, 2023

Kombucha tea from seagrapes ( Caulerpa racemosa) potential as a functional anti-ageing food.Aug 31, 2021

L. fermentum ME-3 has therapeutic potential for reducing the formation/accumulation of some glycation products.Jan 27, 2020

Loganin improved diabetic nephropathy in vivo.Feb 14, 2015

Lycopene provides protection against development of diabetic nephropathy.Oct 09, 2015

Musa sapientum extract inhibited protein glycation, regenerated the islet cells and improved erythrocyte antioxidant status in diabetic rats.Aug 31, 2015

Myricetin inhibits advanced glycation end product-induced migration of retinal pericytesFeb 14, 2015

Oligonol attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic mice.Jan 31, 2015

Pomegranate is promising in development a functional biomolecule in treatment and protection against diabetic complications as nephropathy.Oct 02, 2022

Prevention of advanced glycation end-products formation in diabetic rats through beta-cell modulation by Aegle marmelos.Apr 20, 2017

Protective effect of vanillin on diabetic nephropathy by decreasing advanced glycation end products.Dec 14, 2019

Protective effects of rutin on liver injury in type 2 diabetic db/db mice.Aug 19, 2018

Pterostilbene improves insulin resistance caused by advanced glycation end products.Jun 02, 2021

Rosmarinic acid inhibits DNA glycation and modulates the expression of Akt1 and Akt3 partially in the hippocampus of diabetic rats.Oct 17, 2021

Rosmarinic acid showed a stronger protective effect than carnosic acid in mitigating diabetic symptoms in rats.Jan 25, 2018

Selected dietary components alone or in combination with other therapeutic approaches could prevent diabetes-related complications.Nov 30, 2016

Standardized Mori ramulus extract improves insulin secretion and insulin sensitivity in C57BLKS/J db/db mice and INS-1 cells.Jul 31, 2017

Taurine could be effective to ameliorate oxidative damage and inflammation in the brain.Oct 24, 2017

These results propose eugenol has dual mode of action in combating diabetes.Jan 06, 2016

These results provide novel insights into the antiobesity and antiglycation roles of dietary genistein in obese subjects.Jul 14, 2020

This is the first study demonstrating the protective effects of chrysin on the diabetes-associated malfunctioned visual cycle.Aug 07, 2018

Treatment with raw garlic extract may attenuate the degree of modulations in RAGE expression in type-1 diabetes.Mar 04, 2016

Xanthohumol alleviated T2DM-induced liver steatosis and fibrosis by mediating the NRF2/RAGE/NF-κB signaling pathway.Sep 22, 2021

Advanced glycation end products in diabetes, cancer and phytochemical therapy.Jul 07, 2020

Cocoa melanoidins reduce the formation of dietary advanced glycation end-products in dairy mimicking system.May 29, 2021

Peanut skin polyphenols inhibit toxicity induced by advanced glycation end-products in RAW264.7 macrophages.Aug 09, 2020

A phenolic-enriched maple syrup extract has protective effects against AGEs-induced cytotoxicity.Jan 22, 2017

A review of the management of diabetes mellitus with puerarin.Dec 31, 2017

Anti-Glycation Agents

View the Evidence:
152 Abstracts with Anti-Glycation Agents Research