Anti-metastatic

Name	AC	CK
Curcumin	90	117
Ginsenosides	31	43
EGCG (Epigallocatechin gallate)	18	32
Thymoquinone	27	31
Resveratrol	23	30
Quercetin	16	24
Apigenin	12	21
Melatonin	15	21
Berberine	17	20
Polyphenols	15	20
Flavonoids	11	19
Huaier (Trametes robiniophila murr)	15	19
Luteolin	13	19
Shikonin	11	18
Sulforaphane	15	18
Honokiol	13	17
Vitamin C	11	17
Baicalein	15	16
Cannabidiol	11	16
Delta-tetrahydrocannabinol (THC)	9	15
Fucoidan	12	15
Reishi Mushroom	9	15
Blueberry	7	14
Bromelain	3	13
Cannabinoids	11	13
Pterostilbene	7	13
Selenium	4	13
Cannabis	7	12
Kaempferol	6	12
Pineapple	2	12
Cucurbitacin B	10	11
Green Tea	7	11
Bisdemethoxycurcumin	6	10
Cannabinoids: Synthetic	6	10
Deguelin	9	10
Nobiletin	8	10
Gingerol	8	9
Myricetin	4	9
Paeoniflorin	7	9
Piperlongumine	6	9
Pomegranate	7	9
Zerumbone	4	9
Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine)	3	8
Fisetin	6	8
Garlic	4	8
Genistein	6	8
Ginger	8	8
Parthenolide	3	8
Vitamin D	8	8
Wogonin	7	8
Apple Polyphenols	3	7
Astragaloside	6	7
Betulinic acid	5	7
Catechin	6	7
Ellagic Acid	4	7
Emodin	5	7
Ginseng	2	7
Piperine	3	7
Stilbenes	3	7
Artemisinin	5	6
Beta-Elemene	5	6
Cordyceps Militaris	2	6
Fucoxanthin	2	6
Ginkgo biloba	4	6
Lycopene	4	6
Magnolol	4	6
Mangiferin	5	6
Orange: Mandarin	2	6
Phloretin	2	6
Piceatannol	5	6
Theanine	4	6
6-Shogaol	4	5
Andrographis	4	5
Anthocyanins	5	5
Arctigenin	5	5
Benzyl isothiocyanate	5	5
Black Raspberry	1	5
Crocin	4	5
Dandelion	4	5
Feverfew	1	5
Ginseng (Korean)	4	5
Holy Basil	3	5
Naringenin	5	5
Nigella sativa (aka Black Seed)	4	5
Oridonin	1	5
Panax Notoginseng	4	5
Phenethyl isothiocyanate	5	5
Prunella vulgaris	5	5
Puerarin	4	5
Silibinin	5	5
Tangeretin	3	5
Tanshinone IIA	5	5
Turmeric	4	5
Verbascoside	4	5
Allicin	3	4
Carrot	3	4
Cucurbitacin E	3	4
Gold (nanoparticles)	3	4
Isoliquiritigenin	3	4
Isothiocyanates	4	4
Lysine	2	4
MSM (Methylsulfonylmethane)	3	4
Mistletoe	2	4
Proline	2	4
Sea Cucumber	2	4
Tomato	3	4
Ursolic Acid	4	4
Xanthohumol	4	4
Aloe Vera	2	3
Amygdalin	3	3
Antineoplaston A5	1	3
Antineoplastons	1	3
Astaxanthin	2	3
Berbamine	2	3
Bergamot orange	2	3
Burdock	3	3
Caffeic acid phenethyl ester	2	3
Chrysin	3	3
DHA (Docosahexaenoic Acid)	2	3
Demethoxycurcumin	3	3
Diosgenin	3	3
False Black Pepper	3	3
Ferulic acid	3	3
Fig	2	3
Fish Oil	2	3
Folate	2	3
Germanium	2	3
Hesperidin	2	3
Homeopathic Medicine: All	2	3
Lithospermum erythrorhizon	2	3
Lotus	3	3
Maitake Mushroom	2	3
Manuka Honey	3	3
Medicinal Mushrooms	2	3
Oleuropein	3	3
Peach	2	3
Phyllanthus amarus	3	3
Phyllanthus niruri (Stonebreaker)	3	3
Phyllanthus urinaria	3	3
Pine Bark Extract	3	3
Pomegranate Peel	3	3
Rhubarb	3	3
S-Adenosylmethionine (SAMe)	2	3
Strawberry	2	3
Sweet Potato	2	3
Tocotrienol: Delta	3	3
Trichosanthes Kirilowii	2	3
Vanillin	3	3
Vitamin E	3	3
Adlay	2	2
Alpha-Lipoic Acid	2	2
Amla Fruit	1	2
Apple Pectin	1	2
Ashwagandha	2	2
Asparagus	2	2
Baking Soda	1	2
Bamboo	1	2
Bee Propolis	1	2
Bee Venom	2	2
Bifidobacterium Longum	1	2
Bitter Melon	1	2
Black Pepper	1	2
Boswellia	1	2
Broccoli	1	2
Bufalin	2	2
Cabbage	1	2
Caffeic Acid	2	2
Chaga Mushroom (Inonotus obliquus)	2	2
Chinese Skullcap	2	2
Chlorogenic Acid	1	2
Cinnamaldehyde	2	2
Cloudberry	1	2
Coffee	2	2
Coleus Forskohlii	1	2
Collards	1	2
Coptis chinensis	2	2
Crocetin	2	2
Curcumin: Lipidated	1	2
DIM (3,3'-diindolylmethane)	1	2
Delphinidin	2	2
EPA (Eicosapentaenoic Acid)	1	2
Endocannabinoids	2	2
Essential Oils: Unspecified	1	2
Fenugreek	1	2
Fermented Foods and Beverages	1	2
Flaxseed	2	2
Frankincense	2	2
Gac	2	2
Gallic Acid	1	2
Genipin	2	2
Goji	2	2
Grape	2	2
Hibiscus sabdariffa	1	2
Hops	2	2
Ketone Bodies	1	2
Lactobacillus casei	1	2
Ligustrazine	2	2
Litchi	1	2
Long Pepper	1	2
Loquat Leaves	2	2
Mangosteen	1	2
Marigold	2	2
Milk: Fermented	1	2
Mulberry	1	2
Mushrooms: All	1	2
Nordihydroguaiaretic acid (NDGA)	1	2
Onion	2	2
Palash	1	2
Panax Ginseng	2	2
Pantethine	1	2
Phellinus Linteus	1	2
Prickly Pear Cactus	1	2
Psychedelics:All	2	2
Red Sage	2	2
Red Yeast Rice	1	2
Rosemaric Acid	2	2
Rosemary	1	2
Sesamin	1	2
Sophora Flavescens	2	2
St. Johns Wort	2	2
Stearic Acid (stearate)	1	2
Syrian rue	2	2
Tetrahydrocurcumin	2	2
Thistle	2	2
Triptolide	1	2
Venom: Snake	2	2
Vitamin A	2	2
Vitamin K	1	2
Vitamin K2	1	2
Walnut	2	2
4-Shogaol	1	1
African Basil	1	1
Agaricus Blazei	1	1
Amygdalin (laetrile)	1	1
Antrodia camphorata	1	1
Artesunate	1	1
Artichoke	1	1
Basil	1	1
Beans: All	1	1
Berberis amurensis	1	1
Bergamot	1	1
Betaine	1	1
Black Currant	1	1
Cafestol	1	1
Capsaicin	1	1
Catechols	1	1
Chamomile	1	1
Chili pepper	1	1
Chokeberry	1	1
Chrysanthemum Indicum	1	1
Citrus Peel	1	1
Citrus naringin	1	1
Coptidis rhizoma	1	1
Cordyceps sinensis	1	1
Coriandrum sativum	1	1
Cruciferous Vegetables	1	1
Cucurbitacin D	1	1
Curcuminoids	1	1
Curry Leaves	1	1
D-Limonene	1	1
Daisy	1	1
Dracaena draco	1	1
Eggplant	1	1
Epimedium	1	1
Eugenol	1	1
False Daisy	1	1
Fiber	1	1
Fruit: All	1	1
Ganoderma colossum	1	1
Garcinia Mangostana	1	1
Garcinia indica	1	1
Geum japonicum	1	1
Glycyrrhizin	1	1
Grape Seed Extract	1	1
Graviola	1	1
Guggul	1	1
Gynostemma	1	1
Honey	1	1
Hydroxytyrosol	1	1
Icogenin	1	1
Indole-3-Carbinol	1	1
Juniper	1	1
Krill	1	1
Lichens	1	1
Licorice	1	1
Lignans	1	1
Maple Syrup	1	1
Milk Thistle	1	1
Nettle	1	1
Nexrutine (Phellodendrom)	1	1
Olive	1	1
Olive Oil	1	1
Olive leaf extract	1	1
P-Coumaric Acid	1	1
Palm Oil	1	1
Papaya	1	1
Parsley	1	1
Passion Flower	1	1
Phytoalexins	1	1
Pine Needle	1	1
Plum	1	1
Poria cocos	1	1
Potato	1	1
Probiotics	1	1
Punicalagin	1	1
Punicic acid	1	1
Purslane	1	1
Raspberry	1	1
Rheum palmatum	1	1
Rice Bran	1	1
Rice: Black	1	1
Rose	1	1
Rosmarinic acid	1	1
Rutin	1	1
Saffron	1	1
Schisandra	1	1
Seaweed	1	1
Seaweed: Brown	1	1
Sodium Bicarbonate	1	1
Spirulina	1	1
Tabebuia	1	1
Tannic Acid	1	1
Tea	1	1
Theaflavins	1	1
Tocotrienols	1	1
Tomatidine	1	1
Toona sinensis	1	1
Turmerones	1	1
Urolithin A	1	1
Vegetables: All	1	1
Water: Deep Sea	1	1
Water: Deuterium Depleted	1	1
Water: Electrolyzed Reduced	1	1
White Mulberry	1	1
Wormwood	1	1
beta-Carotene	1	1
β-ionone	1	1

[+]

A meta-analysis of ginsenoside Rg3 combined with chemotherapy for digestive system cancer in China.Dec 31, 2018

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Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:2417418. Epub 2019 Dec 17. PMID: 31929811

Article Published Date : Dec 31, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Ginsenosides

Diseases : Colorectal Cancer, Esophageal Cancer, Gastric Cancer, Liver Cancer, Pancreatic Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Chemotherapeutic

[+]

"Although BRCA positive patients have more frequently negative prognostic factors, their prognosis appears to be equal to or better than in patients with BRCA-WT."Dec 31, 2004

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Pubmed Data : Sci Rep. 2017 12 7 ;7(1):17188. Epub 2017 Dec 7. PMID: 29215048

Article Published Date : Jan 06, 2017

Study Type : Human Study

Additional Links

Substances : Vitamin C

Diseases : Cancer Metastasis, Pancreatic Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

[+]

Tea polyphenol has potential to be a therapeutic adjuvant against human metastatic breast cancer.Feb 01, 2012

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Pubmed Data : Curr Mol Med. 2012 Feb 1 ;12(2):163-76. PMID: 22280355

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Pubmed Data : PLoS One. 2016 ;11(1):e0146553. Epub 2016 Jan 11. PMID: 26752181

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Pubmed Data : Cancer Invest. 2010 May ;28(4):357-63. PMID: 19916793.

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Pubmed Data : PLoS One. 2016 ;11(3):e0150407. Epub 2016 Mar 2. PMID: 26934679

Article Published Date : Dec 31, 2015

Study Type : Human In Vitro, In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Breast Cancer, Cancer Metastasis

Pharmacological Actions : Anti-metastatic

Additional Keywords : Cancer Stem Cells

[+]

Zerumbone has chemotherapeutic effects on human melanoma cells by altering mitochondrial function.Mar 31, 2017

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Pubmed Data : Oncol Lett. 2017 Apr ;13(4):2397-2402. Epub 2017 Feb 14. PMID: 28454410

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

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A polyphenol-rich strawberry extract exerts important biological activities against a highly invasive breast cancer cell line.Aug 07, 2016

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Pubmed Data : Sci Rep. 2017 Jan 30 ;7:41656. Epub 2017 Jan 30. PMID: 28134352

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Pubmed Data : Oncol Res. 2019 Aug 8 ;27(8):889-899. Epub 2019 Apr 2. PMID: 30940289

Article Published Date : Aug 07, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Gleditsia sinensis

Diseases : Breast Cancer, Liver Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Plant Extracts

[+]

Apoptosis and metastasis inhibitory potential of pineapple vinegar against mouse mammary gland cells.Dec 31, 2018

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Pubmed Data : Phytomedicine. 2011 Jan 15 ;18(2-3):158-62. Epub 2010 Aug 23. PMID: 20739158

Article Published Date : Jan 14, 2011

Study Type : Animal Study, In Vitro Study

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Substances : Artemisinin

Diseases : Liver Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Ascorbate supplementation hinders metastasis, tumor growth and inflammatory cytokine secretion as well as enhanced encapsulation of tumors elicited by melanoma and breast cancer.Dec 31, 2012

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Pubmed Data : Int J Oncol. 2013 Jan ;42(1):55-64. Epub 2012 Nov 21. PMID: 23175106

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Pubmed Data : Cell Biochem Funct. 2020 Apr 13. Epub 2020 Apr 13. PMID: 32283563

Article Published Date : Apr 12, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Betulinic acid

Diseases : Gastric Cancer

Pharmacological Actions : Anti-Apoptotic, Anti-metastatic, Antiproliferative

[+]

Bicarbonate increases tumor pH and inhibits spontaneous metastases.Mar 14, 2009

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Caffeic acid phenethyl ester may be a potential therapeutic agent for patients with advanced PCa.May 14, 2016

Carnosol may represent a promising therapeutic candidate that canmodulate breast cancer growth and metastasis.Dec 31, 2018

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Pubmed Data : Phytother Res. 2019 Sep 4. Epub 2019 Sep 4. PMID: 31486124

Article Published Date : Sep 03, 2019

Study Type : Animal Study, In Vitro Study

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Substances : Satsuma

Diseases : Melanoma: Metastasis

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Cloudberry and its compounds possess strong chemopreventive activity against colon cancer.May 29, 2016

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Pubmed Data : Sci Rep. 2018 Oct 24 ;8(1):15726. Epub 2018 Oct 24. PMID: 30356079

Article Published Date : Oct 23, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Fisetin

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative

Additional Keywords : Natural Substances Versus Drugs

[+]

Cordyceps militaris fraction inhibits the invasion and metastasis of lung cancer cellsNov 30, 2018

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Curcumin modulates hepatocellular carcinoma by reducing UNC119 expression.Dec 31, 2018

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Pubmed Data : J Environ Pathol Toxicol Oncol. 2019 ;38(3):195-203. PMID: 31679307

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cancer Metastasis, Liver Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Curcumin not only inhibits tumor angiogenesis, but also suppresses the production of VEGF in response to hypoxia.Aug 13, 2015

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Pubmed Data : Oncotarget. 2015 Aug 14 ;6(23):19469-82. PMID: 26254223

Article Published Date : Aug 13, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: All

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Vascular Endothelial Growth Factor Inhibitors

[+]

Curcumin suppressed phthalate-induced cell migration, invasion and epithelial-mesenchymal transition, decreased the proportion of CSC-like cells.Nov 19, 2015

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Pubmed Data : J Agric Food Chem. 2015 Nov 20. Epub 2015 Nov 20. PMID: 26585812

Article Published Date : Nov 19, 2015

Pubmed Data : Eur J Pharmacol. 2015 Jul 5 ;758:188-96. Epub 2015 Apr 8. PMID: 25863259

Article Published Date : Jul 04, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Breast Cancer, Breast Cancer: Metastatic

Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation.Dec 31, 2014

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Pubmed Data : Oncotarget. 2015 ;6(12):9854-76. PMID: 25918249

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Isoliquiritigenin

Diseases : Breast Cancer, Lung Cancer

Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents

Additional Keywords : Cancer Stem Cells, Epigenetic Modification In Cancer

[+]

Dietary delphinidin inhibits human colorectal cancer metastasis associating with upregulation of miR-204-3p and suppression of the integrin/FAK axisDec 11, 2019

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Pubmed Data : Asian Pac J Trop Med. 2016 Feb ;9(2):180-3. Epub 2016 Jan 11. PMID: 26919952

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor A Inhibitor, Vascular Endothelial Growth Factor C Inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo.Jul 18, 2017

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Pubmed Data : Ann Thorac Surg. 2010 Mar;89(3):781-786. PMID: 18339885

Article Published Date : Mar 01, 2010

Study Type : Transgenic Animal Study

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Substances : Genistein

Diseases : Cancer Metastasis, Prostate Cancer

Pharmacological Actions : Anti-metastatic

[+]

Genistein reinforces the inhibitory effect of Cisplatin on liver cancer recurrence and metastasis after curative hepatectomy.Dec 31, 2012

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Pubmed Data : Cell Prolif. 2016 Dec ;49(6):678-697. Epub 2016 Aug 18. PMID: 27641938

Article Published Date : Nov 30, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Gold (nanoparticles), Quercetin

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic

[+]

Gomisin A has the potential to reduce metastatic melanoma through its anti-proliferative and anti-metastatic effects.Dec 06, 2019

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Pubmed Data : Nutrients. 2015 ;7(7):5065-87. Epub 2015 Jun 24. PMID: 26115086

[+]

Huaier restrains proliferative and migratory potential of hepatocellular carcinoma cells.Dec 31, 2016

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Pubmed Data : J Cancer. 2017 ;8(19):4087-4097. Epub 2017 Nov 6. PMID: 29187885

Article Published Date : Dec 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Huaier (Trametes robiniophila murr)

Diseases : Liver Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Hyperbaric oxygen therapy significantly reduced the number and area of metastatic lesions in the triple negative model.Dec 31, 2016

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Pubmed Data : Phytomedicine. 2018 Nov 15 ;50:19-24. Epub 2018 Sep 18. PMID: 30466978

Article Published Date : Nov 14, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Prickly Pear Cactus

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

[+]

Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer.Nov 30, 2019

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Pubmed Data : Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):3465-3477. PMID: 31432702

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Pubmed Data : Int J Med Sci. 2017 ;14(10):984-993. Epub 2017 Aug 18. PMID: 28924370

Article Published Date : Dec 31, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Kaempferol

Diseases : Kidney Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : treatment outcome

[+]

Kaempferol might act as a therapeutic potential candidate for cancer metastasis.Jan 31, 2015

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Pubmed Data : Biochem Cell Biol. 2015 Feb ;93(1):16-27. Epub 2014 Sep 12. PMID: 25453494

Article Published Date : Jan 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Kaempferol

Diseases : Breast Cancer: Triple Negative , Melanoma

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Korean Red Ginseng extracts might have the ability to reduce the incidence of leukemia.Sep 30, 2016

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Pubmed Data : J Ginseng Res. 2016 Oct ;40(4):431-436. Epub 2016 Aug 4. PMID: 27746697

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Pubmed Data : Oncotarget. 2017 Jan 3 ;8(1):915-932. PMID: 27906672

Article Published Date : Jan 02, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Cancer Metastasis, Liver Cancer

Pharmacological Actions : Anti-metastatic

[+]

Liquiritigenin potentiates the inhibitory effects of cisplatin on invasion and metastasis in B16F10 melanoma cells.Dec 31, 2014

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Pubmed Data : Nutr Cancer. 2015 ;67(5):761-70. Epub 2015 May 15. PMID: 25978595

Substances : S-Adenosylmethionine (SAMe)

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

[+]

Methylsulfonylmethane and tamoxifen synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts.Jun 18, 2015

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Pubmed Data : J Exp Clin Cancer Res. 2019 Jan 3 ;38(1):2. Epub 2019 Jan 3. PMID: 30606241

Article Published Date : Jan 02, 2019

Study Type : Animal Study, In Vitro Study

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Substances : NAC (N-acetyl-L-cysteine)

Diseases : Glioblastoma

Pharmacological Actions : Anti-metastatic, Antioxidants, Antiproliferative , Apoptotic

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Nano curcumin may be an effective therapeutic modality for cervical cancer.Dec 31, 2015

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Pubmed Data : Sci Rep. 2016 ;6:20051. Epub 2016 Feb 3. PMID: 26837852

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Curcumin

Diseases : Cervical Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , MicroRNA modulator

Additional Keywords : E6 Oncoprotein

Problem Substances : Benzo(a)pyrene

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Nanoparticle conjugation of ginsenoside Rg3 inhibits hepatocellular carcinoma development and metastasis.Dec 08, 2019

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Pubmed Data : Cell Death Dis. 2013 Oct 31 ;4:e891. Epub 2013 Oct 31. PMID: 24176849

Article Published Date : Oct 30, 2013

Study Type : Animal Study

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Substances : Parthenolide

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Antiproliferative , Autophagy Up-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Peach polyphenols inhibited tumor growth and reduced the risk of metastasis in MDA-MB-435 cells at levels achievable with diet.Mar 18, 2014

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Pubmed Data : J Nutr Biochem. 2014 Mar 19. Epub 2014 Mar 19. PMID: 24745759

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Shikonin inhibited the viability, migration and invasion of SW480 cells.Feb 14, 2017

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Pubmed Data : Eur J Pharmacol. 2017 Feb 15 ;797:1-8. Epub 2017 Jan 12. PMID: 28088387

Article Published Date : Feb 14, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Shikonin

Diseases : Cancer Metastasis, Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative

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Shikonin reduced the activation and expression of STAT3, FAK and Src in vivo and reduced tumorigenicity, growth and metastasis of 4T1 cells.Dec 31, 2014

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Pubmed Data : Sci Rep. 2015 ;5:10194. Epub 2015 May 14. PMID: 25973915

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Lithospermum erythrorhizon, Shikonin

Diseases : Breast Cancer, Breast Cancer: Metastatic

Pharmacological Actions : Anti-metastatic, Antiproliferative , STAT3 Inhibitor

Additional Keywords : Cancer Stem Cells

[+]

Silymarin suppresses HepG2 hepatocarcinoma cell progression.Jan 31, 2020

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Pubmed Data : Pharmacol Rep. 2020 Feb ;72(1):199-207. Epub 2020 Jan 8. PMID: 32016841

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Pubmed Data : J Clin Invest. 2010 Apr 1;120(4):1043-55. Epub 2010 Mar 24. PMID: 17849266

Article Published Date : Apr 01, 2010

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Cancer Metastasis, Melanoma

Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Interleukin-1 beta downregulation, Interleukin-2 upregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Tanshinone IIA restrained the gastric cancer progression by miR-874/HMGB2/β-catenin signalling in vitro.Jun 01, 2020

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View the Evidence: 1371 Abstracts with Anti-metastatic Research

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A meta-analysis of ginsenoside Rg3 combined with chemotherapy for digestive system cancer in China.Dec 31, 2018

"Although BRCA positive patients have more frequently negative prognostic factors, their prognosis appears to be equal to or better than in patients with BRCA-WT."Dec 31, 2004

Bromelain has antimetastic protential as demonstrated in lung cancer cells - Article 1. Jan 01, 1988

FOLFIRI and FOLFOX6 chemotherapies result in a median progression free survival time of between 7.7 and 8.4 months.Jul 01, 2010

High dose parenteral ascorbate inhibited pancreatic cancer growth and metastasis.Jan 06, 2017

Tea polyphenol has potential to be a therapeutic adjuvant against human metastatic breast cancer.Feb 01, 2012

These results indicate that whey protein concentrate might deplete tumour cells of glutathione and render them more vulnerable to chemotherapy.Oct 31, 1995

These results suggest a preventive effect of selenium on prostate cancer progression rather than on prostate cancer development.Jan 05, 2017

A Black Raspberry extract could prevent the initiation, promotion, and progression of carcinogenesis in the digestive tract and esophagus.Oct 27, 2014

An extract of G. lucidum spores suppressed cholangiocarcinoma migration in vitro through inhibition of TGF-β1-induced EMT.May 14, 2016

Apigenin could be a useful compound to prevent proliferation and migration of cancer cells as well as cancer stem cells.Aug 24, 2016

Apigenin is a novel therapeutic candidate for melanoma.Feb 13, 2017

Bisdemethoxycurcumin induced changes in gene expression that may reveal cytotoxic information on the genetic level.Jan 10, 2015

Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.Nov 14, 2012

Cordycepin inhibited migration of human glioblastoma cells by affecting lysosomal degradation and protein phosphatase activation.Dec 28, 2016

Curcumin inhibited the migratory and invasive ability of A549 cells via the inhibition of adiponectin expression.Dec 31, 2014

Curcumin reduced Akt expression, cell proliferation, and migration in MDA-MB-231 breast cancer cells.Dec 31, 2015

Diallyl disulfide could be a promising anticancer agent for anti-metastatic treatment of esophageal-gastric junction adenocarcinoma in the future.Jan 31, 2018

Fucoxanthin activates apoptosis and suppresses invasion and migration glioblastoma cells.Sep 30, 2016

Ginsenoside 20(S)-Rh2 has therapeutic potential for the treatment with colorectal cancer.Dec 23, 2016

Mandarin juice exerts in vitro antiproliferative effects on anaplastic thyroid carcinoma cells, associated with a reduction of migration.Sep 11, 2015

Nanoparticular thymoquinone attenuates angiogenesis and metastasis of triple-negative breast cancer.Mar 31, 2020

Parthenolide is a potential novel therapeutic agent for aggressive colorectal cancer treatment.Mar 31, 2017

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

Resveratrol markedly decreased the overexpression of miR-196b/miR-1290 and elevated IGFBP3 expression in the ALL cell lines.Dec 14, 2016

Shikonin and temozolomide may constitute a powerful new tool for Glioblastoma treatment by reducing therapy resistance and tumor recurrence.Apr 10, 2017

Silibinin may be a potentially useful therapeutic agent and chemosensitizer for esophageal cancer.Dec 31, 2015

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

THC inhibited cell proliferation, migration and invasion, and induced cell apoptosis in cholangiocarcinoma cells. Apr 30, 2010

The apple polyphenol phloretin inhibits colorectal cancer cell growth.Sep 13, 2016

The results showed that 105 miRNAs were significantly differentially in oridonin-treated BxPC-3 human pancreatic cancer cells.Dec 31, 2014

These results show that breast cancer stem cells, in both a canine and a human cell lines are responsive to melatonin treatment.Dec 31, 2015

Zerumbone has chemotherapeutic effects on human melanoma cells by altering mitochondrial function.Mar 31, 2017

"Antineoplaston A in cancer therapy. (I)."Jan 01, 1977

"Phase I clinical studies of antineoplaston A5 injections."Jan 01, 1987

Antineoplaston A2 has anticancer effects. Jan 01, 1987

Case report: long-term survival following treatment with antineoplastons for colon cancer with unresectable multiple liver metastases.Jan 01, 2003

The use of Iscador as the sole modality for the adjuvant treatment of metastatic melanoma was extremely effective and very well tolerated achieving complete response and absence of all complaints.Apr 30, 2007

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

Targeted delivery of honokiol by zein/hyaluronic acid core-shell nanoparticles to suppress breast cancer growth and metastasis.Jul 14, 2020

"Anti-metastasis effect of thymoquinone on human pancreatic cancer"Jul 31, 2011

"Antineoplaston AS2-1 showed an antimetastatic effect against post-operative lung metastases from colon cancer through G1 cell arrest and the subsequent induction of apoptosis."Mar 01, 2005

(-)-Epigallocatechin-3-gallate (EGCG) can inhibit the proliferation and invasiveness and induce apoptosis in nasopharyngeal carcinoma cells.Dec 31, 2014

10-Gingerol improves doxorubicin anticancer activity and decreases its side effects in triple negative breast cancer models.Aug 05, 2020

10-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo.Sep 21, 2017

20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.Dec 31, 2018

6-Shogaol decreases cancer-induced up-regulation of CCL2 in TADCs, preventing the enhancing effects of TADCs on tumorigenesis and metastatic properties in A549 and MDA-MB-231 cells.Feb 17, 2015

A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma.Jul 31, 2015

A lipid-soluble ginseng extract potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner.Dec 31, 2014

A mixture containing ascorbic acid, lysine, proline and green tea extract inhibits angiogenesis of tumor cells.Dec 01, 2006

A novel combination of ketogenic diet, ketone supplementation and hyperbaric oxygen therapy could be used to manage metastatic cancers.Dec 31, 2014

A polyphenol-rich strawberry extract exerts important biological activities against a highly invasive breast cancer cell line.Aug 07, 2016

A polysaccharide from Punica granatum has an inhibitory effect on metastasis. May 24, 2017

A specific mixture of nutrients suppresses ovarian cancer A-2780 tumor incidence, growth, and metastasis to lungs.Mar 17, 2017

A steroidal derivative from Trigonella foenum graecum L. that induces apoptosis in vitro and in vivo.Dec 31, 2018

A synthetic cannabinoid inhibited CXCL12-induced migration and invasive properties of breast cancer cells.Dec 31, 2010

Administration of quercetin at 15mg/kg body weight resulted in a ~70% reduction in tumor growth.Dec 31, 2015

Allicin inhibits the proliferation and invasion in cholangiocarcinoma.May 21, 2018

Aloesin could be a novel therapeutic treatment for ovarian cancer.Dec 31, 2016

Altogether these data suggest M1 is an efficient candidate for melanoma therapy.Jan 31, 2016

Aluminium salts could be environmental breast carcinogens.Dec 14, 2016

Amauroderma rude could inhibit cancer cell survival and induce apoptosis, also there were fewer and smaller colonies than the untreated cells.Dec 31, 2012

Amla extract modulates cancer cells and the tumor microenvironment.Apr 24, 2016

An aqueous extract of bamboo exerts anti-metastatic effects on highly malignant cancer.Dec 31, 2012

An extract of Litchi seed has potential for development into a safe and potent alternative therapy for prostate cancer patients.Jan 29, 2017

Andrographis paniculata was shown to possess anti-tumor, anti-metastatic and immunomodulatory activities in esophageal cancer cell.Mar 11, 2019

Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma.Oct 21, 2019

Anti-metastatic properties of a potent herbal combination in cell and mice models of triple negative breast cancer.Feb 14, 2020

Anti-neoplastic effect of mangiferin on human ovarian adenocarcinoma OVCAR8 cells.Dec 31, 2018

Anticancer effects of Gleditsia sinensis extract in rats transplanted with hepatocellular carcinoma cells.Aug 07, 2019

Apoptosis and metastasis inhibitory potential of pineapple vinegar against mouse mammary gland cells.Dec 31, 2018

Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma.Nov 11, 2019

Anti-metastatic

View the Evidence:
1371 Abstracts with Anti-metastatic Research