Anticonvulsants

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126 Substances Researched for Anticonvulsants
NameACCKFocus
Cannabidiol67385Locked
Melatonin435Locked
Omega-3 Fatty Acids230Locked
Cannabis625Locked
Curcumin1223Locked
Vitamin B-12322Locked
Gastrodin619Locked
Peony314Locked
Berberine510Locked
Cannabinoids 810Locked
Evening Primrose Oil110Locked
Folate110Locked
Flavonoids59Locked
Rose 47Locked
Bacopa46Locked
Huperzine46Locked
Nigella sativa (aka Black Seed)46Locked
Piperine36Locked
Delta-tetrahydrocannabinol (THC)25Locked
Beta-Caryophyllene24Locked
Cannabidivarin34Locked
Ellagic Acid24Locked
Ginsenosides24Locked
Jujube24Locked
Lemongrass24Locked
Nutmeg24Locked
Palmitoylethanolamide 24Locked
Passion Flower24Locked
Passion fruit24Locked
Pterostilbene24Locked
Royal Jelly24Locked
Sinomenine24Locked
Tanshinone IIA24Locked
Valerian24Locked
Moringa oleifera13Locked
Resveratrol23Locked
Rosemaric Acid23Locked
Vinpocetine13Locked
Acai12Locked
Arginine12Locked
Ashwagandha12Locked
Asiatic Acid12Locked
Asparagus12Locked
Astaxanthin12Locked
Baicalein12Locked
Banana Stem12Locked
Basil12Locked
Bay leaf12Locked
Biochanin A12Locked
Bitter Apple12Locked
Bitter Orange12Locked
Butterfly Pea12Locked
Cannabinoids: Synthetic12Locked
Carnosine12Locked
Chrysin12Locked
Coenzyme Q1012Locked
Coriandrum sativum12Locked
Curcumin: Lipidated12Locked
Dill12Locked
Diosgenin12Locked
Echinacea12Locked
Elderberry12Locked
Eugenol12Locked
Fenugreek12Locked
Fig12Locked
Fisetin12Locked
Folic Acid 12Locked
Geraniol 12Locked
Globimetula Braunii12Locked
Henbane12Locked
Hesperidin12Locked
Hyssop 12Locked
Icariin12Locked
Linden (Tilia)12Locked
Lotus 12Locked
Luteolin12Locked
Mulberry12Locked
Myo-inositol12Locked
NAC (N-acetyl-L-cysteine)12Locked
Nettle12Locked
Oleuropein12Locked
Oligosaccharides12Locked
Orthosiphon12Locked
Paeoniflorin12Locked
Pear12Locked
Peppermint12Locked
Phyllanthus emblica12Locked
Pine Needle12Locked
Poria cocos12Locked
Potato12Locked
Probiotics12Locked
Progesterone12Locked
Pycnogenol (Pine Bark)12Locked
Quercetin12Locked
Rutin12Locked
Safranal12Locked
Seaweed: Brown 12Locked
Sesamin12Locked
Sesamol12Locked
Shilajit12Locked
Skullcap: Blue12Locked
Solanum nigrum (black nightshade)12Locked
Spikenard12Locked
Stigmasterol12Locked
Sulforaphane12Locked
Tangeretin 12Locked
Tarragon12Locked
Thyme12Locked
Thymoquinone12Locked
Turmeric12Locked
Turmerones12Locked
Vitamin D12Locked
Vitexins12Locked
Zataria multiflora12Locked
ibogaine12Locked
Anthocyanins11Locked
Bael 11Locked
Cannabichromene 11Locked
Plantago11Locked
Raspberry11Locked
Reishi Mushroom11Locked
Rose: Essential Oil11Locked
Saffron11Locked
Vitamin C11Locked
Vitex negundo11Locked
Wogonin11Locked

View the Evidence:
264 Abstracts with Anticonvulsants Research

[+]

This systematic review found that add-on melatonin therapy improved sleep latency and seizure severity in patients with epilepsy.Feb 22, 2024

Pubmed Data : Seizure. 2024 Feb 23 ;117:133-141. Epub 2024 Feb 23. PMID: 38417212
Article Published Date : Feb 22, 2024
Study Type : Meta Analysis, Review
Additional Links
Substances : Melatonin
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

A review and meta-analysis of the efficacy and safety of cannabidiol in epilepsy.Nov 02, 2018

Pubmed Data : Drugs. 2018 Nov 3. Epub 2018 Nov 3. PMID: 30390221
Article Published Date : Nov 02, 2018
Study Type : Meta Analysis
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Adjunctive CBD resulted in a greater reduction in convulsive seizure frequency.Feb 09, 2020

Pubmed Data : CNS Drugs. 2020 Feb 10. Epub 2020 Feb 10. PMID: 32040850
Article Published Date : Feb 09, 2020
Study Type : Meta Analysis, Review
Additional Links
Substances : Cannabidiol
Diseases : Dravet syndrome
Pharmacological Actions : Anticonvulsants
[+]

Ketogenic diet for epilepsy: an overview of systematic review and meta-analysis.Jan 12, 2022

Pubmed Data : Eur J Clin Nutr. 2022 Jan 13. Epub 2022 Jan 13. PMID: 35027683
Article Published Date : Jan 12, 2022
Study Type : Meta Analysis, Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Omega-3 supplementation resulted in beneficial effects on seizure frequency in adult and children with epilepsy.Jul 29, 2021

Pubmed Data : Nutr Neurosci. 2021 Jul 30:1-10. Epub 2021 Jul 30. PMID: 34328397
Article Published Date : Jul 29, 2021
Study Type : Meta Analysis, Review
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

A combination of gastrodin, folate, and vitamin-B12 in addition to standard antiepileptic treatment can effectively control epileptic seizures.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Nov ;14(5):4801-4806. Epub 2017 Sep 14. PMID: 29201182
Article Published Date : Oct 31, 2017
Study Type : Human Study
Additional Links
Substances : Folate, Gastrodin, Vitamin B-12
Diseases : Epilepsy, Stroke: Attenuation/Recovery
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Interleukin-2 Downregulation, Interleukin-6 Downregulation
[+]

A ketogenic diet has anticonvulsant and neuroprotective effects. Jan 01, 2010

Pubmed Data : Przegl Lek. 2010;67(3):205-12. PMID: 20687386
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Parkinson's Disease
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Acupuncture has therapeutic value in the treatment of acute herpes zoster pain. Jan 01, 2009

Pubmed Data : BMC Complement Altern Med. 2009;9:31. Epub 2009 Aug 12. PMID: 19674449
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Herpes Zoster
Therapeutic Actions : Acupuncture
Pharmacological Actions : Analgesics, Anticonvulsants
[+]

Add-on cannabidiol may be an efficacious long-term treatment option for treatment-resistant epilepsies.Jul 11, 2018

Pubmed Data : Epilepsia. 2018 Jul 12. Epub 2018 Jul 12. PMID: 29998598
Article Published Date : Jul 11, 2018
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Artisanal cannabidiol-enriched cannabis may be an effective and safe long-term treatment for refractory epilepsy.Jun 27, 2022

Pubmed Data : Pediatr Neurol. 2022 Jun 28 ;136:15-19. Epub 2022 Jun 28. PMID: 36049378
Article Published Date : Jun 27, 2022
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Beyond seizure control, patients experienced a marked improvement in behavior and awareness. Dec 01, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Med Port. 2019 Dec 2 ;32(12):760-766. Epub 2019 Dec 2. PMID: 31851885
Article Published Date : Dec 01, 2019
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol as an adjuvant treatment in adults with drug-resistant focal epilepsy.Jun 30, 2023

Pubmed Data : Epilepsy Behav. 2023 Jul ;144:109210. Epub 2023 May 15. PMID: 37196452
Article Published Date : Jun 30, 2023
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol for treating Lennox-Gastaut Syndrome and Dravet Syndrome in Korea Dec 27, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Korean Med Sci. 2020 Dec 28 ;35(50):e427. Epub 2020 Dec 28. PMID: 33372424
Article Published Date : Dec 27, 2020
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Dravet syndrome, Lennox-Gastaut Syndrome
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol improves frequency and severity of seizures and reduces adverse events.Aug 08, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsy Behav. 2018 Aug 9. Epub 2018 Aug 9. PMID: 30100226
Article Published Date : Aug 08, 2018
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol in children with treatment-resistant epilepsy with myoclonic-atonic seizures.May 31, 2023

Pubmed Data : Epilepsy Behav. 2023 Jun ;143:109245. Epub 2023 May 12. PMID: 37182500
Article Published Date : May 31, 2023
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy, Seizures, Sturge-Weber Syndrome
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol may be an effective and well-tolerated treatment option for patients with refractory seizures in Tuberous sclerosis complex.Sep 30, 2016

Pubmed Data : Epilepsia. 2016 Oct ;57(10):1617-1624. Epub 2016 Aug 3. PMID: 27696387
Article Published Date : Sep 30, 2016
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Tuberous Sclerosis
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with treatment-resistant epilepsy.Dec 22, 2015

Pubmed Data : Lancet Neurol. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26724101
Article Published Date : Dec 22, 2015
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy, Epilepsy: Childhood
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol reduced the frequency of both focal and generalised seizures with 50 % seizure reduction in 76 % of the cohort.Jun 20, 2024

Pubmed Data : Epilepsy Behav. 2024 Jun 21 ;157:109904. Epub 2024 Jun 21. PMID: 38908033
Article Published Date : Jun 20, 2024
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Lennox-Gastaut Syndrome
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol resulted in a greater reduction in convulsive-seizure frequency among patients with Dravet syndrome.Jan 24, 2017

Pubmed Data : N Engl J Med. 2017 05 25 ;376(21):2011-2020. PMID: 28538134
Article Published Date : Jan 24, 2017
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Dravet syndrome
Pharmacological Actions : Anticonvulsants
Additional Keywords : Significant Treatment Outcome
[+]

Cannabidiol treatment in children with treatment resistant epilepsies led to 42% of children reporting a greater than 80% reduction in seizure frequency and 32% reporting a 25-60% seizure reduction.Nov 30, 2013

Pubmed Data : Epilepsy Behav. 2013 Dec ;29(3):574-7. PMID: 24237632
Article Published Date : Nov 30, 2013
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy, Epilepsy: Childhood, Epileptic Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Treatment Resistant
[+]

Cannabidiol treatment yielded a significant positive effect on seizure load in patients with intractable epilepsy.Jan 05, 2016

Pubmed Data : Seizure. 2016 Jan 6 ;35:41-44. Epub 2016 Jan 6. PMID: 26800377
Article Published Date : Jan 05, 2016
Study Type : Human Study
Additional Links
Substances : Cannabidiol, Cannabis
Diseases : Epilepsy, Epilepsy: Childhood
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts, Significant Treatment Outcome
[+]

Cannabidiol-enriched oil for adult patients with drug-resistant epilepsy.May 28, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsia. 2024 May 29. Epub 2024 May 29. PMID: 38808601
Article Published Date : May 28, 2024
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

CBD could be beneficial for the treatment of brain tumor-related epilepsy.Oct 23, 2017

Pubmed Data : Neurocase. 2017 Oct 24:1-5. Epub 2017 Oct 24. PMID: 29063814
Article Published Date : Oct 23, 2017
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Brain Cancer, Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

CBD was found to have potential benefits as add-on therapy for refractory childhood epilepsies.Mar 07, 2018

Pubmed Data : Epilepsy Behav. 2018 Mar 8. Epub 2018 Mar 8. PMID: 29526578
Article Published Date : Mar 07, 2018
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients.Jan 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Behav. 2023 Feb ;13(2):e2860. Epub 2023 Jan 1. PMID: 36588283
Article Published Date : Jan 31, 2023
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Effect of cannabidiol on interictal epileptiform activity and sleep architecture in children with intractable epilepsy.Jan 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : CNS Drugs. 2021 11 ;35(11):1207-1215. Epub 2021 Oct 22. PMID: 34687005
Article Published Date : Jan 10, 2021
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Effectiveness of cannabidiol in a prospective cohort of children with drug-resistant epileptic encephalopathy.Jun 05, 2020

Pubmed Data : Seizure. 2020 Jun 6 ;80:75-80. Epub 2020 Jun 6. PMID: 32544657
Article Published Date : Jun 05, 2020
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Encephalopathy
Pharmacological Actions : Anticonvulsants
[+]

Efficacy and tolerability of hydroalcoholic extract of Paeonia officinalis in children with intractable epilepsy.Sep 30, 2021

Pubmed Data : Epilepsy Res. 2021 Oct ;176:106735. Epub 2021 Jul 29. PMID: 34388412
Article Published Date : Sep 30, 2021
Study Type : Human Study
Additional Links
Substances : Peony
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Efficacy and tolerance of cannabidiol in the treatment of epilepsy in patients with Rett syndrome.Jul 23, 2023

Pubmed Data : Epilepsia Open. 2023 Jul 24. Epub 2023 Jul 24. PMID: 37485779
Article Published Date : Jul 23, 2023
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy, Rett Syndrome
Pharmacological Actions : Anticonvulsants
Additional Keywords : Natural Substance/Drug Synergy
[+]

Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment-resistant epilepsies.May 25, 2023

Pubmed Data : Epilepsia. 2023 May 26. Epub 2023 May 26. PMID: 37243404
Article Published Date : May 25, 2023
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Eighty five percent of all parents reported a reduction in seizure frequency and 14% reported complete seizure freedom.Apr 28, 2015

Pubmed Data : Epilepsy Behav. 2015 Apr 29. Epub 2015 Apr 29. PMID: 25935511
Article Published Date : Apr 28, 2015
Study Type : Human Study
Additional Links
Substances : Cannabidiol, Cannabis
Diseases : Epilepsy, Epilepsy: Childhood
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Evening primrose is safe, and may have therapeutic action for epileptics.Aug 01, 2007

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 2007 Aug;77(2):101-3. Epub 2007 Aug 30. PMID: 17764919
Article Published Date : Aug 01, 2007
Study Type : Human Study
Additional Links
Substances : Evening Primrose Oil
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Highly purified cannabidiol in the treatment of drug-resistant epilepsies.Sep 30, 2023

Pubmed Data : Epilepsy Behav. 2023 Oct ;147:109409. Epub 2023 Sep 6. PMID: 37677907
Article Published Date : Sep 30, 2023
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Ketogenic diet is an effective and safe non-pharmacologic, non-surgical therapy for the management of drug-resistant epilepsy.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pediatr Res. 2023 Dec ;94(6):1978-1989. Epub 2023 Mar 11. PMID: 36906721
Article Published Date : Nov 30, 2023
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Ketogenic diet is an important non-pharmacological treatment option for patients with intractable epilepsy associated with tuberous sclerosis complex.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Epilepsy Res. 2017 Jun ;7(1):45-49. Epub 2017 Jun 30. PMID: 28775955
Article Published Date : May 31, 2017
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Long-term add-on CBD treatment had an acceptable safety profile in patients with Lennox-Gastaut syndrome and led to sustained reductions in seizures.Feb 10, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsia. 2019 Feb 11. Epub 2019 Feb 11. PMID: 30740695
Article Published Date : Feb 10, 2019
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Lennox-Gastaut Syndrome
Pharmacological Actions : Anticonvulsants
[+]

Long-term efficacy and safety of cannabidiol in patients with treatment-resistant epilepsies.Feb 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsia. 2023 Mar ;64(3):619-629. Epub 2023 Jan 10. PMID: 36537757
Article Published Date : Feb 28, 2023
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants
[+]

Music had beneficial effects on seizure frequency in institutionalized subjects with severe intellectual disability and drug-resistant epilepsy.Aug 31, 2017

Pubmed Data : Psychiatr Danub. 2017 Sep ;29(Suppl 3):399-404. PMID: 28953798
Article Published Date : Aug 31, 2017
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Music
Pharmacological Actions : Anticonvulsants
[+]

Omega-3 fatty acids may be useful in the prevention and treatment of epilepsy. Aug 27, 2009

Pubmed Data : J Agric Food Chem. 2009 Aug 27. PMID: 18511348
Article Published Date : Aug 27, 2009
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Purified pharmaceutical CBD may be an effective and safe adjunctive therapy in refractory epileptic spasms.Mar 09, 2020

Pubmed Data : Epilepsy Behav. 2020 Mar 10 ;106:106988. Epub 2020 Mar 10. PMID: 32169600
Article Published Date : Mar 09, 2020
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Six months after initiating the ketogenic diet it led to a 50% reduction in seizure frequency in those that responded to the diet. Oct 31, 2015

Pubmed Data : Pediatr Neurol. 2015 Nov ;53(5):422-6. Epub 2015 Aug 8. PMID: 26476148
Article Published Date : Oct 31, 2015
Study Type : Human Study
Additional Links
Diseases : Epilepsy: Childhood, Epileptic Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Successful treatment of intractable epilepsy with ketogenic diet therapy in twins with ALG3-CDG.May 06, 2020

Pubmed Data : Brain Dev. 2020 May 7. Epub 2020 May 7. PMID: 32389449
Article Published Date : May 06, 2020
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The ketogenic diet appeared to be an effective therapeutic modality for intractable pediatric epilepsy in tuberous sclerosis complex.Apr 28, 2020

Pubmed Data : Epilepsy Res. 2020 Apr 29 ;164:106348. Epub 2020 Apr 29. PMID: 32413817
Article Published Date : Apr 28, 2020
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The ketogenic diet could be implemented in medium resources countries and should be included in the management of children with intractable epilepsy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsy Behav Case Rep. 2019 ;11:35-38. Epub 2018 Nov 23. PMID: 30619711
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The ketogenic diet is a promising therapy for myoclonic status in non-progressive encephalopathy.Jul 10, 2017

Pubmed Data : Seizure. 2017 Jul 11 ;51:1-5. Epub 2017 Jul 11. PMID: 28743048
Article Published Date : Jul 10, 2017
Study Type : Human Study
Additional Links
Diseases : Encephalopathy, Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
Additional Keywords : Significant Treatment Outcome
[+]

The ketogenic diet significantly improves quality of life, and reduces both seizures and medication needs in most patients wtih Dravet syndrome studied.Sep 01, 2005

Pubmed Data : Epilepsia. 2005 Sep;46(9):1539-44. PMID: 16146451
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Dravet syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
Additional Keywords : Drug Sparing
[+]

The ketogenic diet was beneficial for patients with GLUT-1 deficiency syndrome.Jan 13, 2016

Pubmed Data : Seizure. 2016 Jan 14 ;35:83-87. Epub 2016 Jan 14. PMID: 26803281
Article Published Date : Jan 13, 2016
Study Type : Human Study
Additional Links
Diseases : Epilepsy, Metabolic Diseases
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The results show that the ketogenic diet is effective in Lennox-Gastaut syndrome.Nov 30, 2016

Pubmed Data : Epilepsy Res. 2016 Dec ;128:176-180. Epub 2016 Nov 9. PMID: 27846468
Article Published Date : Nov 30, 2016
Study Type : Human Study
Additional Links
Diseases : Epilepsy, Lennox-Gastaut Syndrome
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The results suggest that CBD may have beneficial effects on patient quality of life, distinct from its seizure-reducing effects.Jun 14, 2017

Pubmed Data : Epilepsia. 2017 Jun 15. Epub 2017 Jun 15. PMID: 28617940
Article Published Date : Jun 14, 2017
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy: Childhood, Quality of Life: Poor
Pharmacological Actions : Anticonvulsants
[+]

These findings support efficacy of artisanal CBD preparations in seizure reduction with few significant side effects.Feb 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsy Behav. 2018 Feb 8. Epub 2018 Feb 8. PMID: 29429908
Article Published Date : Feb 07, 2018
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

This study suggests that cannabidiol may be well tolerated as adjunctive medication for seizure management.Feb 21, 2017

Pubmed Data : Pediatr Neurol. 2017 Feb 22. Epub 2017 Feb 22. PMID: 28454984
Article Published Date : Feb 21, 2017
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Seizures, Sturge-Weber Syndrome
Pharmacological Actions : Anticonvulsants
[+]

This work further confirms the anticonvulsant efficacy of CBD and supports its application in the treatment of human seizure disorders.Jun 14, 2017

Pubmed Data : Epilepsy Behav. 2017 Jun 15 ;73:111-118. Epub 2017 Jun 15. PMID: 28624721
Article Published Date : Jun 14, 2017
Study Type : Human Study
Additional Links
Substances : Cannabidiol
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Three to 6 years after initiation, the ketogenic diet had proven to be effective in the control of difficult-to-control seizures in children.Sep 30, 2001

Pubmed Data : Pediatrics. 2001 Oct ;108(4):898-905. PMID: 11581442
Article Published Date : Sep 30, 2001
Study Type : Human Study
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Treatment with ketogenic diet resulted in a marked improvement in seizures and cognitive functions.Sep 30, 2015

Pubmed Data : Neuropediatrics. 2015 Oct ;46(5):313-20. Epub 2015 Aug 12. PMID: 26267703
Article Published Date : Sep 30, 2015
Study Type : Human Study
Additional Links
Diseases : Glucose Transporter 1 Deficiency Syndrome, Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Vitamin B12 is superior to the drug Nortriptyline in the treatment of diabetic neuropathy.Jan 01, 2009

Pubmed Data : Int J Food Sci Nutr. 2009;60 Suppl 5:71-6. Epub 2009 Feb 11. PMID: 19212856
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin B-12
Diseases : Diabetic Neuropathies, Peripheral Neuropathies
Pharmacological Actions : Anticonvulsants
Additional Keywords : Drug: Nortriptyline, Superiority of Natural Substances versus Drugs
[+]

Ketogenic diet attenuates refractory epilepsy of Harel-Yoon Syndrome with ATAD3A variants.May 31, 2023

Pubmed Data : Pediatr Neurol. 2023 Jun ;143:79-83. Epub 2023 Mar 9. PMID: 37031571
Article Published Date : May 31, 2023
Study Type : Human: Case Report, Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Report of a 6-month-old Asian infant with early infantile epileptic encephalopathy whose seizures were eliminated by cannabidiol.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsy Behav Rep. 2020 ;14:100373. Epub 2020 Jun 8. PMID: 32695984
Article Published Date : Dec 31, 2019
Study Type : Human: Case Report
Additional Links
Substances : Cannabidiol
Diseases : Encephalopathy, Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Significant Treatment Outcome
[+]

"Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases."Oct 31, 1992

Pubmed Data : Epilepsia. 1992 Nov-Dec;33(6):1132-6. PMID: 1464275
Article Published Date : Oct 31, 1992
Study Type : Human: Case Report
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

A 10-month-old boy with malignant migrating partial seizures in infancy made developmental gains and sustained seizure reduction with the addition of cannabidiol to his antiepileptic regimen.Apr 30, 2015

Pubmed Data : Pediatr Neurol. 2015 May ;52(5):544-7. Epub 2015 Feb 19. PMID: 25882081
Article Published Date : Apr 30, 2015
Study Type : Human: Case Report
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy: Infant, Epilepsy: Malignant Migrating Partial Seizures
Pharmacological Actions : Anticonvulsants
[+]

Ameliorative effect of ethanolic extract of Moringa oleifera leaves in combination with curcumin against PTZ-induced kindled epilepsy.Aug 29, 2023

Pubmed Data : Pharmaceuticals (Basel). 2023 Aug 30 ;16(9). Epub 2023 Aug 30. PMID: 37765031
Article Published Date : Aug 29, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin, Moringa oleifera
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Effectiveness of highly purified cannabidiol in refractory and super-refractory status epilepticus.Jun 20, 2024

Pubmed Data : CNS Neurol Disord Drug Targets. 2024 Jun 21. Epub 2024 Jun 21. PMID: 38910424
Article Published Date : Jun 20, 2024
Study Type : Human: Case Report
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Potential role of cannabidiol for seizure control in a patient with recurrent glioma.Dec 13, 2019

Pubmed Data : J Clin Neurosci. 2019 Dec 14. Epub 2019 Dec 14. PMID: 31848037
Article Published Date : Dec 13, 2019
Study Type : Human: Case Report
Additional Links
Substances : Cannabidiol
Diseases : Glioma, Seizures
Pharmacological Actions : Anticonvulsants, Chemotherapeutic
[+]

Precision medicine: Vinpocetine as a potential treatment for GABRG2-related epilepsy.May 31, 2023

Pubmed Data : Epileptic Disord. 2023 Jun ;25(3):383-389. Epub 2023 May 25. PMID: 37536979
Article Published Date : May 31, 2023
Study Type : Human: Case Report
Additional Links
Substances : Vinpocetine
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsy Behav Case Rep. 2018 ;10:141-144. Epub 2018 Jul 17. PMID: 30596011
Article Published Date : Dec 31, 2017
Study Type : Human: Case Report
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:359. Epub 2016 Aug 30. PMID: 27746737
Article Published Date : Dec 31, 2015
Study Type : Human: Case Report
Additional Links
Substances : Cannabidiol, Delta-tetrahydrocannabinol (THC)
Diseases : Epilepsy: Childhood
Pharmacological Actions : Anticonvulsants
[+]

CBD exhibits anti-seizure properties in acute seizure models.May 05, 2017

Pubmed Data : Neurochem Res. 2017 May 6. Epub 2017 May 6. PMID: 28478594
Article Published Date : May 05, 2017
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

A hydro-alcoholic extract of Dill seed demonstrated anticonvulsant activity against PTZ-induced seizures.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Basic Clin Neurosci. 2014 ;5(3):199-204. PMID: 25337380
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Dill
Diseases : Seizures, Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

A hydro-alcoholic extract of R. dam ascena has anticonvulsant and neuroprotective effects.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2015 May-Jun;5(3):260-70. PMID: 26101759
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Rose
Diseases : Seizures, Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

An ethanol extract of Glycyrrhiza glabra poses anti-convulsant potential and ameliorates ROS induced neuronal damage in PTZ-induced seizure.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Indian J Pharmacol. 2013 Jan-Feb;45(1):40-3. PMID: 23543836
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Diseases : Oxidative Stress, Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

An extract of Globimetula braunii leaves possesses psychoactive compound that may be useful in the management of petit mal epilepsy.Mar 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Biomed. 2014 Apr ;4(4):285-9. PMID: 25182552
Article Published Date : Mar 31, 2014
Study Type : Animal Study
Additional Links
Substances : Globimetula Braunii
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Anti-inflammation associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures.Jan 05, 2020

Pubmed Data : J Neuroimmune Pharmacol. 2020 Jan 6. Epub 2020 Jan 6. PMID: 31909440
Article Published Date : Jan 05, 2020
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Epilepsy, Seizures: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants
[+]

Anticonvulsant activity of methanolic extract of Withania cogulans in mice.Nov 30, 2021

Pubmed Data : Metab Brain Dis. 2021 Dec ;36(8):2437-2443. Epub 2021 Oct 7. PMID: 34618296
Article Published Date : Nov 30, 2021
Study Type : Animal Study
Additional Links
Substances : Ashwagandha
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Anticonvulsant and neuroprotective effects of cannabidiol during the juvenile period.Aug 27, 2018

Pubmed Data : J Neuropathol Exp Neurol. 2018 Aug 28. Epub 2018 Aug 28. PMID: 30169677
Article Published Date : Aug 27, 2018
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Anticonvulsant and neuroprotective effects of paeonol in epileptic rats.Oct 31, 2019

Pubmed Data : Neurochem Res. 2019 Nov ;44(11):2556-2565. Epub 2019 Sep 13. PMID: 31520267
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Peony
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents
[+]

Anticonvulsant effect of Asparagus racemosus in a mouse model of catamenial epilepsy.Jan 31, 2022

Pubmed Data : Neurochem Res. 2022 Feb ;47(2):422-433. Epub 2021 Oct 8. PMID: 34623565
Article Published Date : Jan 31, 2022
Study Type : Animal Study
Additional Links
Substances : Asparagus
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Antidepressive Agents
[+]

Anticonvulsant effect of pterostilbene.Jul 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Psychopharmacology (Berl). 2021 Aug 1. Epub 2021 Aug 1. PMID: 34333674
Article Published Date : Jul 31, 2021
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Anticonvulsant effect of the essential oil and methanolic extracts of Zataria multiflora.May 31, 2013

Pubmed Data : Cent Nerv Syst Agents Med Chem. 2013 Jun ;13(2):93-7. PMID: 23565592
Article Published Date : May 31, 2013
Study Type : Animal Study
Additional Links
Substances : Zataria multiflora
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Essential Oils, Phytotherapy, Plant Extracts
[+]

Anticonvulsant effect of turmeric and resveratrol in lithium/pilocarpine-induced status epilepticus.Jun 13, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Jun 14 ;27(12). Epub 2022 Jun 14. PMID: 35744955
Article Published Date : Jun 13, 2022
Study Type : Animal Study
Additional Links
Substances : Curcumin, Resveratrol
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Anticonvulsant effects of Paeonia daurica subsp. macrophylla root extracts in pentylenetetrazol-induced seizure models in mice.Sep 08, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurologia (Engl Ed). 2021 Sep 9. Epub 2021 Sep 9. PMID: 34511273
Article Published Date : Sep 08, 2021
Study Type : Animal Study
Additional Links
Substances : Peony
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Anticonvulsant effects of royal jelly in kainic acid-induced animal model of temporal lobe epilepsy.Jun 30, 2023

Pubmed Data : Neurochem Res. 2023 Jul ;48(7):2187-2195. Epub 2023 Mar 1. PMID: 36856963
Article Published Date : Jun 30, 2023
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants
[+]

Anticonvulsive effect of paeoniflorin on experimental febrile seizures.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(8):e42920. Epub 2012 Aug 16. PMID: 22916181
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Febrile Seizures
Pharmacological Actions : Anticonvulsants
[+]

Anticonvulsive properties of cannabidiol in a model of generalized seizure are transient receptor potential vanilloid 1 dependent.May 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cannabis Cannabinoid Res. 2020 Jun 1 ;5(2):145-149. Epub 2020 Jun 5. PMID: 32656346
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Lennox-Gastaut Syndrome
Pharmacological Actions : Anticonvulsants
[+]

Antiepileptic effects of antioxidant potent extract from Urtica dioica.Jan 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2021 Feb ;7(2):e06195. Epub 2021 Feb 5. PMID: 33644470
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Substances : Nettle
Diseases : Epilepsy: Drug-Induced
Pharmacological Actions : Anticonvulsants, Antioxidants
[+]

Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy.Nov 30, 2013

Pubmed Data : Pharm Biol. 2013 Dec ;51(12):1572-8. Epub 2013 Sep 5. PMID: 24004105
Article Published Date : Nov 30, 2013
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Epileptic Seizures
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Asiatic acid can prevent seizures and improve cognitive impairment.Mar 09, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2021 Mar 10 ;9(3). Epub 2021 Mar 10. PMID: 33802221
Article Published Date : Mar 09, 2021
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Cognitive Decline/Dysfunction, Epilepsy
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Astaxanthin could have an antiepileptic and anti-inflammatory effect by reducing ROS generation.Apr 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi Pharm J. 2021 May ;29(5):418-426. Epub 2021 Apr 9. PMID: 34135667
Article Published Date : Apr 30, 2021
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Epilepsy
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants
[+]

B. monnieri treatments could be effective in managing the neurotransmitter balance in the cerebral cortex.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurochem Res. 2015 Jan ;40(1):216-25. Epub 2014 Dec 13. PMID: 25503823
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Bacopa
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Bacopa monnieri exhibited anti-seizure activity.Feb 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2021 Mar ;11(2):137-143. Epub 2020 Mar 4. PMID: 33728274
Article Published Date : Feb 28, 2021
Study Type : Animal Study
Additional Links
Substances : Bacopa
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Baicalein exerted antiepileptic effects by regulation of IGF1R in a pilocarpine-induced model.Nov 30, 2020

Pubmed Data : Neurochem Res. 2020 Dec ;45(12):3021-3033. Epub 2020 Oct 23. PMID: 33095440
Article Published Date : Nov 30, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Bay leaf essential oil protects against pentylenetetrazole- and maximal electroshock-induced seizures.Apr 01, 2002

Pubmed Data : Phytomedicine. 2002 Apr;9(3):212-6. PMID: 12046861
Article Published Date : Apr 01, 2002
Study Type : Animal Study
Additional Links
Substances : Bay leaf
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Berberine has anticonvulsant activity in mice.Jul 01, 2010

Pubmed Data : Epilepsy Behav. 2010 Jul;18(3):207-10. PMID: 20638957
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Convulsions, Seizures
Pharmacological Actions : Anticonvulsants
[+]

Bitter apple has significant anticonvulsant effects in pentylenetetrazole-induced seizures in miceDec 02, 2015

Pubmed Data : J Evid Based Complementary Altern Med. 2015 Dec 3. Epub 2015 Dec 3. PMID: 26634927
Article Published Date : Dec 02, 2015
Study Type : Animal Study
Additional Links
Substances : Bitter Apple
Diseases : Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Black nightshade (S. nigrum) has anti-seizure activity in experimental animals. Jun 01, 2008

Pubmed Data : Afr Health Sci. 2008 Jun;8(2):74-9. PMID: 19357754
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Solanum nigrum (black nightshade)
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Blue skullcap (S. lateriflora) has anticonvulsant activity. May 01, 2009

Pubmed Data : Phytomedicine. 2009 May;16(5):485-93. Epub 2008 Sep 10. PMID: 18786819
Article Published Date : May 01, 2009
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Skullcap: Blue
Diseases : Convulsions, Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Cannabidiol anticonvulsant effect is mediated by the PI3Kγ pathway. Jun 19, 2020

Pubmed Data : Neuropharmacology. 2020 Jun 20:108156. Epub 2020 Jun 20. PMID: 32574650
Article Published Date : Jun 19, 2020
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol attenuates seizure susceptibility and behavioural deficits.Apr 22, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Neurosci. 2024 Apr 23. Epub 2024 Apr 23. PMID: 38654472
Article Published Date : Apr 22, 2024
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice.Sep 09, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Invest. 2019 Sep 10. Epub 2019 Sep 10. PMID: 31503547
Article Published Date : Sep 09, 2019
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Angelman Syndrome, Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome.Oct 01, 2017

Pubmed Data : Proc Natl Acad Sci U S A. 2017 Oct 2. Epub 2017 Oct 2. PMID: 28973916
Article Published Date : Oct 01, 2017
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Autism, Dravet syndrome, Seizures
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol effect in pentylenetetrazole-induced seizures depends on PI3K.Sep 15, 2022

Pubmed Data : Pharmacol Rep. 2022 Sep 16. Epub 2022 Sep 16. PMID: 36112318
Article Published Date : Sep 15, 2022
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol exerts anticonvulsant effects alone and in combination with Δ9-THC.Mar 06, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2024 Mar 7 ;13(6). Epub 2024 Mar 7. PMID: 38534310
Article Published Date : Mar 06, 2024
Study Type : Animal Study
Additional Links
Substances : Cannabidiol, Cannabinoids , Delta-tetrahydrocannabinol (THC)
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol exhibits an anticonvulsive effect in the rats with chronic epilepsy.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(6):8820-7. Epub 2015 Jun 15. PMID: 26309534
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy, Epilepsy: Drug-Induced
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy modelsDec 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsia. 2018 Dec 26. Epub 2018 Dec 26. PMID: 30588604
Article Published Date : Dec 25, 2018
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Cannabidivarin-rich cannabis extracts exerted significant anticonvulsant effects in three rat models of seizure.Sep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2013 Oct ;170(3):679-92. PMID: 23902406
Article Published Date : Sep 30, 2013
Study Type : Animal Study
Additional Links
Substances : Cannabidiol, Cannabinoids , Cannabis
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat.May 29, 2006

Pubmed Data : Neurosci Lett. 2006 May 29;400(1-2):146-9. Epub 2006 Mar 3. PMID: 16515835
Article Published Date : May 29, 2006
Study Type : Animal Study
Additional Links
Substances : Carnosine
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants
[+]

CBD was effective against brainstem and limbic seizures.Oct 03, 2022

Pubmed Data : Pharmacol Rep. 2022 Oct 4. Epub 2022 Oct 4. PMID: 36195689
Article Published Date : Oct 03, 2022
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Clitoria ternatea and the central nervous system.May 31, 2003

Pubmed Data : Pharmacol Biochem Behav. 2003 Jun ;75(3):529-36. PMID: 12895670
Article Published Date : May 31, 2003
Study Type : Animal Study
Additional Links
Substances : Butterfly Pea
Diseases : Anxiety, Depression, Seizures
Pharmacological Actions : Anti-Anxiety Agents, Anticonvulsants, Antidepressive Agents, Nootropic Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Combination of Vit D3 and melatonin may reduce seizure frequency in epileptic patients.Apr 28, 2022

Pubmed Data : Cent Nerv Syst Agents Med Chem. 2022 Apr 29. Epub 2022 Apr 29. PMID: 35507790
Article Published Date : Apr 28, 2022
Study Type : Animal Study
Additional Links
Substances : Melatonin, Vitamin D
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Concentration- and time-dependent effects of myo-inositol on evoked epileptic afterdischarge in the hippocampus in vivo.Nov 05, 2019

Pubmed Data : Neuroreport. 2019 Nov 6 ;30(16):1129-1134. PMID: 31568207
Article Published Date : Nov 05, 2019
Study Type : Animal Study
Additional Links
Substances : Myo-inositol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats.Oct 10, 2010

Pubmed Data : Eur J Pharmacol. 2010 Oct 10;644(1-3):106-12. Epub 2010 Jul 24. PMID: 20667451
Article Published Date : Oct 10, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Drug-Induced Toxicity , Memory Disorders, Memory Disorders: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anticonvulsants, Antioxidants, Neuroprotective Agents
[+]

Curcumin and NAC protect against valproate-induced liver toxicity. Jan 01, 2010

Pubmed Data : Arzneimittelforschung. 2010;60(11):647-53. PMID: 21175036
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin, NAC (N-acetyl-L-cysteine)
Diseases : Chemically-Induced Liver Damage, Drug-Induced Toxicity: Valproic Acid (Depakote)
Pharmacological Actions : Anticonvulsants, Antioxidants, Hepatoprotective
[+]

Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice.Dec 01, 2008

Pubmed Data : Phytother Res. 2008 Dec;22(12):1660-4. PMID: 18661468
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Curcumin has potential anti-epileptic effects.Jan 01, 2009

Pubmed Data : Indian J Physiol Pharmacol. 2009 Jan-Mar;53(1):39-46. PMID: 19810575
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Epilepsy, Oxidative Stress, Seizures
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats.Dec 08, 2009

Pubmed Data : Brain Res. 2009 Dec 8;1301:52-60. Epub 2009 Sep 16. PMID: 19765566
Article Published Date : Dec 08, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cognitive Decline/Dysfunction, Memory Disorders: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
Additional Keywords : Drug: Phenytoin
[+]

Curcumin protects against seizures and cognitive impairment in a drug-induced epileptic rat model.Sep 16, 2010

Pubmed Data : Life Sci. 2010 Sep 16. Epub 2010 Sep 16. PMID: 20840851
Article Published Date : Sep 16, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Epilepsy, Seizures, Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants
[+]

Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures.Jul 14, 2021

Pubmed Data : J Ethnopharmacol. 2021 Jul 15 ;275:114142. Epub 2021 Apr 25. PMID: 33910044
Article Published Date : Jul 14, 2021
Study Type : Animal Study
Additional Links
Substances : Geraniol , Lemongrass
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Antioxidants, Neuroprotective Agents
[+]

Different fractions of C. sativum aerial parts possess antioxidant activity in the brain.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2016 Mar-Apr;6(2):223-35. PMID: 27222836
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Coriandrum sativum
Diseases : Seizures, Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants, Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Plant Extracts
[+]

Dose dependent anticonvulsant activity of Morus nigra in strychnine induced seizures model.Oct 31, 2021

Pubmed Data : Pak J Pharm Sci. 2021 Nov ;34(6):2167-2171. PMID: 35034877
Article Published Date : Oct 31, 2021
Study Type : Animal Study
Additional Links
Substances : Mulberry
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Dose Response, Plant Extracts
[+]

Dual protective effect of Passiflora incarnata in epilepsy and associated post-ictal depression.Jan 05, 2012

Pubmed Data : J Ethnopharmacol. 2012 Jan 6 ;139(1):273-9. Epub 2011 Nov 15. PMID: 22107833
Article Published Date : Jan 05, 2012
Study Type : Animal Study
Additional Links
Substances : Passion Flower
Diseases : Depression, Epilepsy: Drug-Induced
Pharmacological Actions : Anticonvulsants, Antidepressive Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

E. oleracea significantly protects against seizures and seizure-related oxidative stress.Oct 31, 2015

Pubmed Data : Neurochem Int. 2015 Nov ;90:20-7. Epub 2015 Jul 2. PMID: 26142570
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Acai
Diseases : Brain: Oxidative Stress, Lipid Peroxidation, Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants, Neuroprotective Agents
[+]

Effect of ellagic acid on seizure threshold in two acute seizure tests.Aug 09, 2021

Pubmed Data : Molecules. 2021 Aug 10 ;26(16). Epub 2021 Aug 10. PMID: 34443428
Article Published Date : Aug 09, 2021
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Effects of aqueous extract of Hyssopus officinalis on seizures induced by pentylenetetrazole.Apr 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2020 May-Jun;10(3):213-221. PMID: 32523876
Article Published Date : Apr 30, 2020
Study Type : Animal Study
Additional Links
Substances : Hyssop
Diseases : Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants
[+]

Effects of probiotics on pentylenetetrazol-induced convulsions.Jan 09, 2021

Pubmed Data : Epilepsy Res. 2021 10 ;176:106723. Epub 2021 Jul 12. PMID: 34304017
Article Published Date : Jan 09, 2021
Study Type : Animal Study
Additional Links
Substances : Probiotics
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Gastrointestinal Agents
Additional Keywords : Natural Substance/Drug Synergy
[+]

Elderberry extracts have multiple mechanisms for its anticonvulsant actions.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2016 Jul ;20(14):3123-6. PMID: 27460744
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Elderberry
Diseases : Epilepsy, Epilepsy: Drug-Induced, Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Emblica officnalis protects against drug-induced seizures, oxidative stress and cognitive impairment in rats.May 01, 2010

Pubmed Data : Indian J Exp Biol. 2010 May;48(5):474-8. PMID: 20795364
Article Published Date : May 01, 2010
Study Type : Animal Study
Additional Links
Substances : Phyllanthus emblica
Diseases : Epilepsy, Oxidative Stress, Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants
Additional Keywords : Plant Extracts
[+]

Evaluation of the anticonvulsant and anxiolytic-like activities of aqueous leaf extract of Cymbopogon citratus in mice.Nov 13, 2019

Pubmed Data : J Basic Clin Physiol Pharmacol. 2019 Nov 14. Epub 2019 Nov 14. PMID: 31730523
Article Published Date : Nov 13, 2019
Study Type : Animal Study
Additional Links
Substances : Lemongrass
Diseases : Anxiety, Seizures
Pharmacological Actions : Anti-Anxiety Agents, Anticonvulsants
[+]

Fucosterol, a sterol extracted from Sargassum fusiforme, shows antidepressant and anticonvulsant effects.Dec 04, 2015

Pubmed Data : Eur J Pharmacol. 2015 Dec 5 ;768:131-8. Epub 2015 Oct 26. PMID: 26515446
Article Published Date : Dec 04, 2015
Study Type : Animal Study
Additional Links
Substances : Seaweed: Brown
Diseases : Depression, Seizures
Pharmacological Actions : Anticonvulsants, Antidepressive Agents
[+]

Gastrodin contributed to the alleviation of pediatric epilepsy.Mar 23, 2021

Pubmed Data : Biosci Biotechnol Biochem. 2021 Mar 24 ;85(4):798-804. PMID: 33704382
Article Published Date : Mar 23, 2021
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Gastrodin has potential benefits for stroke and patients with epilepsy.Jun 29, 2016

Pubmed Data : Chin J Physiol. 2016 Jun 30 ;59(3):156-64. PMID: 27188468
Article Published Date : Jun 29, 2016
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Seizures, Stroke
Pharmacological Actions : Anticonvulsants
[+]

Gastrodin showed anti-seizure and neuroprotective abilities. Apr 05, 2021

Pubmed Data : J Ethnopharmacol. 2021 Apr 6 ;269:113751. Epub 2021 Jan 4. PMID: 33359863
Article Published Date : Apr 05, 2021
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy.Dec 18, 2023

Pubmed Data : J Neurochem. 2023 Dec 19. Epub 2023 Dec 19. PMID: 38115597
Article Published Date : Dec 18, 2023
Study Type : Animal Study
Additional Links
Substances : Diosgenin
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Gastrointestinal Agents
[+]

Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties.Nov 02, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2023 Nov 3 ;23(1):393. Epub 2023 Nov 3. PMID: 37924049
Article Published Date : Nov 02, 2023
Study Type : Animal Study
Additional Links
Substances : Basil
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Gastrointestinal Agents
Additional Keywords : Gut-brain Axis
[+]

Henbane exhibits anticonvulsive activity against picrotoxin-induced seizure.Jul 01, 2009

Pubmed Data : Pak J Pharm Sci. 2009 Jul;22(3):308-12. PMID: 19553180
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Henbane
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Huperzine A is a promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease.Jan 31, 2017

Pubmed Data : Med Hypotheses. 2017 Feb ;99:57-62. Epub 2016 Dec 22. PMID: 28110700
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Huperzine
Diseases : Alzheimer's Disease, Seizures
Pharmacological Actions : Anticonvulsants, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Huperzine A provides robust and sustained protection against induced seizures.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:357. Epub 2016 Oct 17. PMID: 27799911
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Huperzine
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants
[+]

Ibogaine confers long-lasting protection against NMDA-induced convulsions in mice.Aug 01, 2000

Pubmed Data : Neurochem Res. 2000 Aug;25(8):1083-7. PMID: 11055745
Article Published Date : Aug 01, 2000
Study Type : Animal Study
Additional Links
Substances : ibogaine
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Icariin ameliorates the cognitive function in an epilepsy neonatal rat model.Dec 31, 2019

Pubmed Data : Folia Neuropathol. 2020 ;58(3):245-252. PMID: 33099294
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Icariin
Diseases : Brain: Oxidative Stress, Epilepsy
Pharmacological Actions : Anti-Apoptotic, Anticonvulsants, Neuroprotective Agents
[+]

Jujuboside B inhibits febrile seizure by modulating AMPA receptor activity.Mar 24, 2023

Pubmed Data : J Ethnopharmacol. 2023 Mar 25 ;304:116048. Epub 2022 Dec 19. PMID: 36549370
Article Published Date : Mar 24, 2023
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Febrile Seizures
Pharmacological Actions : Anticonvulsants
[+]

Ketogenic diet therapy might be uniquely suited to reset the epileptogenic clock and to provide long-lasting relief from seizures even after discontinuation of the diet.Aug 05, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuropharmacology. 2015 Aug 6 ;99:500-509. Epub 2015 Aug 6. PMID: 26256422
Article Published Date : Aug 05, 2015
Study Type : Animal Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
Additional Keywords : DNA Methylation, Epigenetic Modification
[+]

Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice.Mar 31, 2013

Pubmed Data : Fundam Clin Pharmacol. 2013 Apr ;27(2):169-72. Epub 2011 Nov 2. PMID: 22044441
Article Published Date : Mar 31, 2013
Study Type : Animal Study
Additional Links
Substances : Curcumin, Curcumin: Lipidated
Diseases : Epileptic Seizures, Seizures
Pharmacological Actions : Anticonvulsants
[+]

Luteolin had an anticonvulsant effect in an acute pentylenetetrazole model.Nov 30, 2017

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):264-268. PMID: 27927066
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Melatonin can be used in the treatment of seizures.Mar 21, 2016

Pubmed Data : Behav Brain Res. 2016 Mar 22. Epub 2016 Mar 22. PMID: 27016427
Article Published Date : Mar 21, 2016
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Mentha piperita oil exerts an antiepileptic effect in pilocarpine and pentylenetetrazol-induced seizures.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Vet Med Int. 2022 ;2022:4431317. Epub 2022 Sep 22. PMID: 36250185
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Peppermint
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

N. nucifera fruit may be valuable in managing epilepsy.Aug 02, 2017

Pubmed Data : Metab Brain Dis. 2017 Aug 3. Epub 2017 Aug 3. PMID: 28776277
Article Published Date : Aug 02, 2017
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Anticonvulsants, epilepsy, Lotus, Natural Substances Versus Drugs
[+]

Nardostachys jatamansi root extract could increase in the protective index of phenytoin.Nov 30, 2005

Pubmed Data : J Ethnopharmacol. 2005 Dec 1 ;102(3):351-6. Epub 2005 Aug 10. PMID: 16095854
Article Published Date : Nov 30, 2005
Study Type : Animal Study
Additional Links
Substances : Spikenard
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Neroli possesses biologically active constituents that have anticonvulsant activity.Oct 31, 2014

Pubmed Data : Nat Prod Commun. 2014 Nov ;9(11):1615-8. PMID: 25532295
Article Published Date : Oct 31, 2014
Study Type : Animal Study
Additional Links
Substances : Bitter Orange
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Essential Oils
[+]

Neuroprotection impact of biochanin A against pentylenetetrazol-kindled mice: Targeting NLRP3 inflammasome/TXNIP pathway and autophagy modulationJan 31, 2023

Pubmed Data : Int Immunopharmacol. 2023 Feb ;115:109711. Epub 2023 Jan 12. PMID: 36640710
Article Published Date : Jan 31, 2023
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Epilepsy
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Antioxidants, Neuroprotective Agents
[+]

Neuroprotective and anticonvulsant effects of sinomenine in kainate rat model of temporal lobe epilepsy.Jan 09, 2020

Pubmed Data : J Chem Neuroanat. 2020 10 ;108:101800. Epub 2020 May 8. PMID: 32430101
Article Published Date : Jan 09, 2020
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Neuroprotective effect of berberine nanoparticles against seizures in pentylenetetrazole induced kindling model of epileptogenesis.Jun 16, 2023

Pubmed Data : Neurochem Res. 2023 Jun 17. Epub 2023 Jun 17. PMID: 37329447
Article Published Date : Jun 16, 2023
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Epilepsy
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Anticonvulsants, Antioxidants, Neuroprotective Agents
[+]

Neuroprotective effects of Royal Jelly against pentylenetetrazole-induced seizures.Mar 31, 2023

Pubmed Data : J Chem Neuroanat. 2023 Apr ;129:102255. Epub 2023 Mar 5. PMID: 36878412
Article Published Date : Mar 31, 2023
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Inflammation, Oxidative Stress, Seizures
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Antioxidants, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Nigella sativa oil was found to be the most effective in preventing PTZ-induced seizures relative to valproate.Aug 31, 2005

Pubmed Data : Neuropharmacology. 2005 Sep ;49(4):456-64. PMID: 15913671
Article Published Date : Aug 31, 2005
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants, Malondialdehyde Down-regulation
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Nutmeg extract might be regarded as a useful supplementary agent in epilepsy treatment through its attenuation of neuronal loss and glial activation.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2019 ;18(2):812-825. PMID: 31531064
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Nutmeg
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Nutmeg has anticonvulsant properties. Feb 01, 2009

Pubmed Data : Phytother Res. 2009 Feb;23(2):153-8. PMID: 19067329
Article Published Date : Feb 01, 2009
Study Type : Animal Study
Additional Links
Substances : Nutmeg
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Oleuropein has anticonvulsant activity against pentylenetetrazole induced seizures in mice.Mar 31, 2017

Pubmed Data : J Nat Med. 2017 Apr ;71(2):389-396. Epub 2017 Jan 19. PMID: 28105567
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Oleuropein
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Orthosiphon stamineus proteins alleviate pentylenetetrazol-induced seizures.Jul 01, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2020 Jul 2 ;8(7). Epub 2020 Jul 2. PMID: 32630817
Article Published Date : Jul 01, 2020
Study Type : Animal Study
Additional Links
Substances : Orthosiphon
Diseases : Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants
[+]

P. eldarica prevented neuronal death and reduced seizures caused by pentylenetetrazole via improving brain oxidative stress.Oct 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2021 Nov-Dec;11(6):610-621. PMID: 34804898
Article Published Date : Oct 31, 2021
Study Type : Animal Study
Additional Links
Substances : Pine Needle
Diseases : Brain: Oxidative Stress, Seizures
Pharmacological Actions : Anti-Apoptotic, Anticonvulsants, Antioxidants
[+]

P. tenuifila showed no acute toxicity and had a promising effect as an anxiolytic agent, hypnotic-sedative and anticonvulsant.Jan 31, 2020

Pubmed Data : Food Res Int. 2020 Feb ;128:108813. Epub 2019 Nov 21. PMID: 31955772
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Passion fruit
Diseases : Anxiety, Sleep Disorders
Pharmacological Actions : Anti-Anxiety Agents, Anticonvulsants, Hypnotics and Sedatives
[+]

Palmitoylethanolamide attenuates PTZ-induced seizures through CB1 and CB2 receptors.Oct 31, 2015

Pubmed Data : Epilepsy Res. 2015 Nov ;117:23-8. Epub 2015 Aug 14. PMID: 26370914
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Cannabinoid Receptors
[+]

Pasipay could be useful for treatment absence seizure .Aug 07, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2007 Aug 8 ;7:26. Epub 2007 Aug 8. PMID: 17686156
Article Published Date : Aug 07, 2007
Study Type : Animal Study
Additional Links
Substances : Passion Flower
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Passiflora caerulea L. fruit extract and its metabolites ameliorate epileptic seizure, cognitive deficit and oxidative stress.Nov 13, 2019

Pubmed Data : Metab Brain Dis. 2019 Nov 14. Epub 2019 Nov 14. PMID: 31728889
Article Published Date : Nov 13, 2019
Study Type : Animal Study
Additional Links
Substances : Passion fruit
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Antioxidants, Neuroprotective Agents
[+]

Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.Mar 11, 2018

Pubmed Data : Seizure. 2018 Mar 12 ;57:22-26. Epub 2018 Mar 12. PMID: 29547827
Article Published Date : Mar 11, 2018
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Piperine has anticonvulsant effects in-vivo and in-vitro.Sep 02, 2015

Pubmed Data : Channels (Austin). 2015 Sep 3 ;9(5):317-23. PMID: 26542628
Article Published Date : Sep 02, 2015
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy control.Aug 31, 2019

Pubmed Data : Eur J Pharm Sci. 2019 Sep 1 ;137:104988. Epub 2019 Jul 7. PMID: 31291598
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Potato juice exerts an anticonvulsant effect in mice through binding to GABA receptors.Apr 01, 2008

Pubmed Data : Planta Med. 2008 Apr;74(5):491-6. PMID: 18543146
Article Published Date : Apr 01, 2008
Study Type : Animal Study
Additional Links
Substances : Potato
Diseases : Convulsions
Pharmacological Actions : Anticonvulsants, Benzodiazepine receptor agonist, GABA Modulators
Additional Keywords : Plant Extracts
[+]

Preclinical safety and efficacy of cannabidivarin for early life seizures.Jan 07, 2019

Pubmed Data : Neuropharmacology. 2019 Jan 8. Epub 2019 Jan 8. PMID: 30633929
Article Published Date : Jan 07, 2019
Study Type : Animal Study
Additional Links
Substances : Cannabidivarin
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Progesterone has anticonvulsant activity in mice. Jul 01, 2004

Pubmed Data : J Pharmacol Exp Ther. 2004 Jul;310(1):230-9. Epub 2004 Feb 24. PMID: 14982969
Article Published Date : Jul 01, 2004
Study Type : Animal Study
Additional Links
Substances : Progesterone
Diseases : Convulsions, Seizures
Pharmacological Actions : Anticonvulsants, Enzyme Inhibitors
[+]

Pterostilbene has anticonvulsant activity in acute seizure tests.Jan 27, 2019

Pubmed Data : Neurochem Res. 2019 Jan 28. Epub 2019 Jan 28. PMID: 30689162
Article Published Date : Jan 27, 2019
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Pycnogenol has a protective approach towards the convulsion and can be included as an adjuvant therapy with antiepileptic drugs.Nov 20, 2018

Pubmed Data : Curr Clin Pharmacol. 2018 Nov 21. Epub 2018 Nov 21. PMID: 30465512
Article Published Date : Nov 20, 2018
Study Type : Animal Study
Additional Links
Substances : Pycnogenol (Pine Bark)
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Antioxidants
[+]

R. damascena has an anticonvulsant effect in a mouse model of pentylenetetrazol induced seizures.Sep 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2011 Oct ;9(10):1118-24. PMID: 22015194
Article Published Date : Sep 30, 2011
Study Type : Animal Study
Additional Links
Substances : Rose
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Results showed that ellagic acid increased the seizure threshold and decreased the expression of Nr2a and Nr2b. Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Behav Neurol. 2022 ;2022:9015842. Epub 2022 May 11. PMID: 35600241
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Role of berberine nanoformulation in epilepsy: A novel therapeutic strategy.Jul 17, 2024

Pubmed Data : Epilepsy Res. 2024 Jul 18 ;205:107419. Epub 2024 Jul 18. PMID: 39029440
Article Published Date : Jul 17, 2024
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Rose oil exhibits anti-seizure properties. Mar 01, 2008

Pubmed Data : Pak J Biol Sci. 2008 Mar 1;11(5):746-51. PMID: 18819571
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Rose
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, GABA Modulators
Additional Keywords : Plant Extracts
[+]

Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Epilepsy Behav. 2016 09 ;62:27-34. Epub 2016 Jul 20. PMID: 27448240
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Rosemaric Acid
Diseases : Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants
[+]

Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice.Jan 01, 2018

Pubmed Data : Pharmazie. 2018 04 2 ;73(4):207-212. PMID: 29609687
Article Published Date : Jan 01, 2018
Study Type : Animal Study
Additional Links
Substances : Safranal
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Sakuranetin exerts anticonvulsant effect in bicuculline-induced seizures.Jul 31, 2022

Pubmed Data : Fundam Clin Pharmacol. 2022 Aug ;36(4):663-673. Epub 2022 Feb 21. PMID: 35156229
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

Sesamin could prevent seizure attacks and neurobehavioral and EEG deficits induced by pentylenetetrazol.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2023 ;26(9):1016-1023. PMID: 37605727
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Sesamin
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Sesamol exerts ameliorative effects in the experimental model of epilepsy.Jan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2014 Feb ;17(2):100-7. PMID: 24711892
Article Published Date : Jan 31, 2014
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Epilepsy, Oxidative Stress
Pharmacological Actions : Anticonvulsants, Antioxidants
[+]

Shilajit has antiepileptic and antipsychotic activities in experimental animals.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anc Sci Life. 2015 Oct-Dec;35(2):110-7. PMID: 26865744
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Substances : Shilajit
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Antipsychotic Agents
[+]

Short-term potentiation of the eCB system might modify the epileptogenic disease process in patients with a progressive course of epilepsy.May 31, 2015

Pubmed Data : Pharmacol Rep. 2015 Jun ;67(3):501-3. Epub 2014 Dec 17. PMID: 25933961
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Cannabinoids: Synthetic
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Endocannabinoid System
[+]

Sinomenine exerts anticonvulsant and neuroprotective activity in pentylenetetrazole kindling model of epilepsy.May 17, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neuroinflammation. 2018 May 18 ;15(1):152. Epub 2018 May 18. PMID: 29776417
Article Published Date : May 17, 2018
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Epilepsy
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Neuroprotective Agents
[+]

Stigmasterol can be new steroidal treatment for neurological disorders.Jun 29, 2021

Pubmed Data : Phytomedicine. 2021 Jun 30 ;90:153646. Epub 2021 Jun 30. PMID: 34280827
Article Published Date : Jun 29, 2021
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Anxiety, Epilepsy
Pharmacological Actions : Anti-Anxiety Agents, Anticonvulsants, GABA Modulators
[+]

Subchronic administration of palmitoylethanolamide significantly alleviates seizure intensity, promotes neuroprotection.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Mol Neurosci. 2018 ;11:67. Epub 2018 Mar 14. PMID: 29593494
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Sulforaphane has anticonvulsant properties and could improve mitochondrial function.Sep 13, 2015

Pubmed Data : J Neurochem. 2015 Sep 14. Epub 2015 Sep 14. PMID: 26365487
Article Published Date : Sep 13, 2015
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants, Nrf2 activation
[+]

Supplementation with folic acid and l-arginine has an antiepileptic effect in dl homocysteine thiolactone induced epilepsy.Jun 21, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 Jun 22:1-7. Epub 2016 Jun 22. PMID: 27494641
Article Published Date : Jun 21, 2016
Study Type : Animal Study
Additional Links
Substances : Arginine, Folic Acid
Diseases : High Homocysteine, Seizures
Pharmacological Actions : Anticonvulsants
[+]

T. americana var. mexicana significantly prevented severity of PTZ-induced seizures and attenuated oxidative stress levels.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2014 ;2014:329172. Epub 2014 Aug 13. PMID: 25197430
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Linden (Tilia), Quercetin, Rutin
Diseases : Oxidative Stress, Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants
Additional Keywords : Plant Extracts
[+]

Tangeretin exerted potent neuroprotective effects against pilocarpine-induced seizures.Aug 31, 2017

Pubmed Data : Adv Med Sci. 2017 Sep ;62(2):246-253. Epub 2017 May 11. PMID: 28501723
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Tangeretin
Diseases : Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
Additional Keywords : Anticonvulsants, Neuroprotective Agents, Seizures: Drug-Induced, Tangeretin
[+]

Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.Nov 19, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ACS Chem Neurosci. 2013 Nov 20 ;4(11):1479-87. Epub 2013 Sep 6. PMID: 23937066
Article Published Date : Nov 19, 2013
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Tanshinone IIA shows antiepileptic and cognitive function-improving effects.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2023 Dec ;61(1):100-110. PMID: 36548216
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Tarragon (Artemisia d.) essential oil has anticonvulsant activity, confirming its traditional use in Iranian folkloric medicine.Feb 15, 2008

Pubmed Data : Clin Cancer Res. 2008 Feb 15;14(4):1248-57. PMID: 15325732
Article Published Date : Feb 15, 2008
Study Type : Animal Study
Additional Links
Substances : Tarragon
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts, Science Confirms Tradition
[+]

The anticonvulsant and anti-plasmid conjugation potential of Thymus vulgaris chemistry.Jul 24, 2018

Pubmed Data : Food Chem Toxicol. 2018 Jul 25 ;120:472-478. Epub 2018 Jul 25. PMID: 30055314
Article Published Date : Jul 24, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Thyme
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

The anticonvulsant effects of piperine ameliorate memory impairment, inflammation and oxidative stress in a rat model of pilocarpine-induced epilepsy.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Feb ;13(2):695-700. Epub 2016 Dec 27. PMID: 28352353
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Piperine
Diseases : Epilepsy: Drug-Induced
Pharmacological Actions : Anticonvulsants, Antioxidants
[+]

The effect of coenzyme Q10 on liver injury induced by valproic acid and its antiepileptic activity.Jan 12, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2022 Jan 13 ;10(1). Epub 2022 Jan 13. PMID: 35052847
Article Published Date : Jan 12, 2022
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anticonvulsants
Additional Keywords : Natural Substance/Drug Synergy
[+]

The overall results indicate that gastrodin attenuates pentylenetetrazole-induced seizures in a concentration-dependent manner.Mar 31, 2018

Pubmed Data : Neurochem Res. 2018 Apr ;43(4):904-917. Epub 2018 Feb 7. PMID: 29417472
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Epilepsy, Oxidative Stress, Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Dose Response
[+]

The present study demonstrated the anti-epileptogenic effect of berberine.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Epilepsy Res. 2018 Dec ;8(2):66-73. Epub 2018 Dec 31. PMID: 30809499
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Epilepsy
Pharmacological Actions : Anti-Apoptotic, Anticonvulsants, Antioxidants
[+]

The results concluded that hesperidin suppresses pentylenetetrazole-mediated seizure.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:607797. Epub 2021 Jan 11. PMID: 33505312
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Epilepsy: Drug-Induced
Pharmacological Actions : Anticonvulsants
[+]

The results from this study suggest the presence of significant anticonvulsant activity in M. sapientum stem extract.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacognosy Res. 2018 Jan-Mar;10(1):49-54. PMID: 29568187
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Banana Stem
Diseases : Drug-Induced Toxicity: Epilepsy Drugs
Pharmacological Actions : Anticonvulsants, Antioxidants
[+]

The robust anticonvulsant effects of CBD may result from multiple pharmacological mechanisms.Aug 14, 2017

Pubmed Data : Epilepsy Behav. 2017 Aug 15 ;75:29-35. Epub 2017 Aug 15. PMID: 28821005
Article Published Date : Aug 14, 2017
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants
[+]

These findings provide evidence that eugenol has therapeutic potential for epileptic seizures.Feb 18, 2023

Pubmed Data : Exp Biol Med (Maywood). 2023 Feb 19:15353702231151976. Epub 2023 Feb 19. PMID: 36802956
Article Published Date : Feb 18, 2023
Study Type : Animal Study
Additional Links
Substances : Eugenol
Diseases : Epilepsy
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Interleukin-1 beta downregulation
[+]

These findings revealed the anticonvulsive and antiepileptogenesis effects of the E. purpurea root extract.Aug 30, 2021

Pubmed Data : J Complement Integr Med. 2021 Aug 31. Epub 2021 Aug 31. PMID: 34461009
Article Published Date : Aug 30, 2021
Study Type : Animal Study
Additional Links
Substances : Echinacea
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

These findings suggested that ginsenoside compound K exerted anti-epileptic effects by promoting the hippocampal GABA release.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1020. Epub 2018 Sep 11. PMID: 30254585
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, GABA Modulators
[+]

These results demonstrated that Jujuboside A exhibits an antiepileptogenic effect by alleviating oxidative stress and inflammatory responses.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:7792791. Epub 2022 Sep 9. PMID: 36118077
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Brain Injury: Traumatic, Epilepsy
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Antioxidants
[+]

These results reinforce the potential role of CBD in the treatment of epileptic disorders.Dec 31, 2016

Pubmed Data : Front Pharmacol. 2017 ;8:131. Epub 2017 Mar 17. PMID: 28367124
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

These results suggest ar-turmerone as a potentially safe antiepileptic drug candidate with influence on the expression of two relevant seizure-related genes.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(12):e81634. Epub 2013 Dec 13. PMID: 24349101
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Turmeric, Turmerones
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Gene Expression Regulation
[+]

These results suggested that ginsenosides have anticonvulsant effects that are more prominent during the luteal phase than the follicular phaseJul 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Razi Inst. 2023 Aug ;78(4):1359-1364. Epub 2023 Aug 31. PMID: 38226383
Article Published Date : Jul 31, 2023
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

These results support Ficus carica and oligosaccharides potential anticonvulsant-activity.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2019 Oct ;9(4):263-270. Epub 2018 Sep 28. PMID: 31453121
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Fig, Oligosaccharides
Diseases : Seizures: Convulsive
Pharmacological Actions : Anticonvulsants
[+]

This demonstrate the potential of CBD as a novel antiepileptic drug in the unmet clinical need associated with generalized seizures.Jan 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2010 Feb ;332(2):569-77. Epub 2009 Nov 11. PMID: 19906779
Article Published Date : Jan 31, 2010
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Seizures
Pharmacological Actions : Anticonvulsants
[+]

This study demonstrated the antiepileptic action of fisetin in iron-induced model of epileptic rats.May 18, 2016

Pubmed Data : Nutr Neurosci. 2016 May 19:1-10. Epub 2016 May 19. PMID: 27198489
Article Published Date : May 18, 2016
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Antioxidants
[+]

Thymoquinone increased the potency of valproate in both PTZ and MES models.Dec 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Health Sci (Qassim). 2008 Jan ;2(1):15-25. PMID: 21475467
Article Published Date : Dec 31, 2007
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Natural Substance/Drug Synergy
[+]

Total triterpenes extracted from P. cocos possessed potential antiepileptic properties.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2016 Nov ;54(11):2528-2535. Epub 2016 May 9. PMID: 27159135
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Trigonelline as an anticonvulsant agent: mechanistic insights into NMDA receptor expression and oxidative stress balance.Jun 19, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2024 Jun 20 ;14(1):14239. Epub 2024 Jun 20. PMID: 38902338
Article Published Date : Jun 19, 2024
Study Type : Animal Study
Additional Links
Substances : Fenugreek
Diseases : Oxidative Stress, Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants, Malondialdehyde Down-regulation
[+]

Valerenic acid and valerian extracts have anticonvulsant properties in adult zebrafish. Jul 13, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 Jul 14 ;15:228. Epub 2015 Jul 14. PMID: 26168917
Article Published Date : Jul 13, 2015
Study Type : Animal Study
Additional Links
Substances : Valerian
Diseases : Seizures: Drug-Induced
Pharmacological Actions : Anticonvulsants
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
[+]

Valerian has anticonvulsive properties. Feb 03, 2010

Pubmed Data : J Ethnopharmacol. 2010 Feb 3;127(2):313-8. Epub 2009 Nov 10. PMID: 19900527
Article Published Date : Feb 03, 2010
Study Type : Animal Study
Additional Links
Substances : Valerian
Diseases : Convulsions, Convulsive Seizures
Pharmacological Actions : Anticonvulsants
[+]

Vitamin B12 is a potential strategy and treatment for epilepsy and other related epileptogenesis activities.Feb 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2023 Mar ;15(3):e35929. Epub 2023 Mar 9. PMID: 37050999
Article Published Date : Feb 28, 2023
Study Type : Animal Study
Additional Links
Substances : Vitamin B-12
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Vitexin possesses anticonvulsant and anxiolytic-like effects in murine animal models. Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:1181. Epub 2020 Aug 11. PMID: 32848784
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Vitexins
Diseases : Anxiety, Epilepsy
Pharmacological Actions : Anti-Anxiety Agents, Anticonvulsants
[+]

Wild Himalayan pear could be considered as a potential and alternative therapeutic option in the management of epilepsy.Dec 27, 2017

Pubmed Data : Nutr Neurosci. 2017 Dec 28:1-9. Epub 2017 Dec 28. PMID: 29284373
Article Published Date : Dec 27, 2017
Study Type : Animal Study
Additional Links
Substances : Chrysin, Pear
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

β-caryophyllene has anticonvulsant, anxiolytic and antidepressant properties. Jan 08, 2020

Pubmed Data : Curr Mol Pharmacol. 2020 05 9. Epub 2020 May 9. PMID: 32386503
Article Published Date : Jan 08, 2020
Study Type : Animal Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Anxiety, Depression
Pharmacological Actions : Anti-Anxiety Agents, Anticonvulsants, Antidepressive Agents
[+]

Cannabidiol normalizes resting-state functional connectivity in treatment-resistant epilepsy.Jul 29, 2020

Pubmed Data : Epilepsy Behav. 2020 Jul 30 ;112:107297. Epub 2020 Jul 30. PMID: 32745959
Article Published Date : Jul 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

"The ketogenic diet: mechanism of anticonvulsant action."Dec 31, 1979

Pubmed Data : Adv Neurol. 1980 ;27:635-42. PMID: 6990715
Article Published Date : Dec 31, 1979
Study Type : Review
Additional Links
Diseases : Convulsive Seizures, Epileptic Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

A review of huperzine A as a neuroprotective and antiepileptic treatment. Dec 31, 2015

Pubmed Data : Expert Rev Neurother. 2016 06 ;16(6):671-80. Epub 2016 Apr 20. PMID: 27086593
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Huperzine
Diseases : Epilepsy
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Interleukin-1 beta downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A review of ketogenic diets in the treatment of epilepsy.Aug 08, 2017

Pubmed Data : Curr Pharm Des. 2017 Aug 9. Epub 2017 Aug 9. PMID: 28799513
Article Published Date : Aug 08, 2017
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

A review of the potential efficacy of saffron in cognitive dysfunction and seizures.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Prev Nutr Food Sci. 2019 Dec ;24(4):363-372. Epub 2019 Dec 31. PMID: 31915630
Article Published Date : Nov 30, 2019
Study Type : Review
Additional Links
Substances : Saffron
Diseases : Cognitive Decline/Dysfunction, Learning disorders, Memory Disorders, Seizures
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

A review of the therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis.Feb 08, 2017

Pubmed Data : Epilepsy Behav. 2017 Feb 9. Epub 2017 Feb 9. PMID: 28190698
Article Published Date : Feb 08, 2017
Study Type : Review
Additional Links
Substances : Cannabidiol, Cannabinoids
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol.Jun 04, 2016

Pubmed Data : Brain. 2016 Jun 5. Epub 2016 Jun 5. PMID: 27267376
Article Published Date : Jun 04, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

An overview of the management of post-vasectomy pain syndrome.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian J Androl. 2016 May-Jun;18(3):332-7. PMID: 26952956
Article Published Date : Apr 30, 2016
Study Type : Review
Additional Links
Pharmacological Actions : Anticonvulsants
Anti Therapeutic Actions : Vasectomy
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[+]

An overview of the preclinical pharmacological properties of Nigella sativa.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Physiol Pharmacol. 2016 Dec ;67(6):801-817. PMID: 28195061
Article Published Date : Nov 30, 2016
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Asthma, Cancers: All, Hyperlipidemia, Hypertension, Inflammation, Pain, Ulcers
Pharmacological Actions : Analgesics, Anti-Asthmatic Agents, Anti-Inflammatory Agents, Anti-Ulcer Agents, Anticonvulsants, Antihypertensive Agents, Antimicrobial, Antioxidants, Hypolipidemic, Immunomodulatory
Additional Keywords : Asthma, Cancers: All, hyperlipidemia, hypertension, Inflammation, Nigella sativa (aka Black Seed), pain, Ulcers
[+]

Anti-seizure medications for Lennox-Gastaut syndrome.Apr 06, 2021

Pubmed Data : Cochrane Database Syst Rev. 2021 Apr 7 ;4:CD003277. Epub 2021 Apr 7. PMID: 33825230
Article Published Date : Apr 06, 2021
Study Type : Review
Additional Links
Substances : Cannabidiol
Diseases : Lennox-Gastaut Syndrome
Pharmacological Actions : Anticonvulsants
[+]

Bacosides: a study of neurobiological activity, prospects for application.Dec 31, 2022

Pubmed Data : Zh Nevrol Psikhiatr Im S S Korsakova. 2023 ;123(10):54-59. PMID: 37966440
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Bacopa
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants
[+]

Cannabidiol as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome.Feb 28, 2019

Pubmed Data : Drugs Today (Barc). 2019 Mar ;55(3):177-196. PMID: 30938373
Article Published Date : Feb 28, 2019
Study Type : Review
Additional Links
Substances : Cannabidiol
Diseases : Lennox-Gastaut Syndrome
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol could enhance the induction of autophagy pathway and antioxidant defense in the chronic phase of epilepsy,Jan 05, 2016

Pubmed Data : J Mol Neurosci. 2016 Jan 6. Epub 2016 Jan 6. PMID: 26738731
Article Published Date : Jan 05, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Antioxidants, Autophagy Up-regulation
[+]

Cannabidiol for adjuvant treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome.Jan 09, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacoeconomics. 2020 10 ;38(10):1043-1053. PMID: 32514751
Article Published Date : Jan 09, 2020
Study Type : Review
Additional Links
Substances : Cannabidiol
Diseases : Lennox-Gastaut Syndrome, Seizures
Pharmacological Actions : Anticonvulsants
[+]

Cannabidiol inhibits febrile seizure by modulating AMPA receptor kinetics.Aug 13, 2020

Pubmed Data : Pharmacol Res. 2020 Aug 14:105128. Epub 2020 Aug 14. PMID: 32805354
Article Published Date : Aug 13, 2020
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Febrile Seizures
Pharmacological Actions : Anticonvulsants
[+]

Cannabinoids in epilepsy: clinical efficacy and pharmacological considerations.Nov 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neurologia (Engl Ed). 2021 Nov 22. Epub 2021 Nov 22. PMID: 34824031
Article Published Date : Nov 21, 2021
Study Type : Review
Additional Links
Substances : Cannabinoids
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Cannabis and epilepsy: An ancient treatment returns to the fore.Dec 14, 2016

Pubmed Data : Epilepsy Behav. 2016 Dec 15. Epub 2016 Dec 15. PMID: 27989385
Article Published Date : Dec 14, 2016
Study Type : Review
Additional Links
Substances : Cannabis
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
Additional Keywords : Plant Extracts
[+]

Cannabis for refractory epilepsy in children: A review focusing on CDKL5 deficiency disorder.Dec 31, 2018

Pubmed Data : Epilepsy Res. 2019 03 ;151:31-39. Epub 2019 Feb 5. PMID: 30771550
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Cannabis
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Curcumin reduces development of seizurelike eventsFeb 11, 2019

Pubmed Data : Epilepsia. 2019 Feb 12. Epub 2019 Feb 12. PMID: 30747999
Article Published Date : Feb 11, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Epilepsy
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Effect of the ketogenic diet as a treatment for refractory epilepsy in children and adolescents.Jul 02, 2023

Pubmed Data : Nutr Rev. 2023 Jul 3. Epub 2023 Jul 3. PMID: 37400987
Article Published Date : Jul 02, 2023
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

Effects of ganoderic acids on epileptiform discharge hippocampal neurons: insights from alterations of BDNF,TRPC3 and apoptosis.May 31, 2016

Pubmed Data : Pharmazie. 2016 Jun ;71(6):340-4. PMID: 27455554
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Epilepsy
Pharmacological Actions : Anti-Apoptotic, Anticonvulsants, Neuroprotective Agents
[+]

Efficacy of cannabinoids in paediatric epilepsy.Dec 31, 2018

Pubmed Data : Dev Med Child Neurol. 2019 Jan ;61(1):13-18. Epub 2018 Nov 6. PMID: 30402932
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Cannabidiol, Cannabinoids
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Galangin prevents increased susceptibility to pentylenetetrazol-stimulated seizures by prostaglandin E2.Jan 09, 2019

Pubmed Data : Neuroscience. 2019 08 10 ;413:154-168. Epub 2019 Jun 11. PMID: 31200106
Article Published Date : Jan 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Inflammation, Seizures: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Postaglandin PGE2 downregulation
[+]

Highly purified cannabidiol for epilepsy treatment: A systematic review of epileptic conditions.Feb 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : CNS Drugs. 2021 Mar ;35(3):265-281. Epub 2021 Mar 22. PMID: 33754312
Article Published Date : Feb 28, 2021
Study Type : Review
Additional Links
Substances : Cannabidiol
Diseases : Dravet syndrome, Lennox-Gastaut Syndrome
Pharmacological Actions : Anticonvulsants
[+]

Huperzine A may have therapeutic value in treating seizures. Aug 01, 2009

Pubmed Data : Epilepsy Behav. 2009 Aug;15(4):529-34. Epub 2009 Jul 17. PMID: 19616481
Article Published Date : Aug 01, 2009
Study Type : Commentary
Additional Links
Substances : Huperzine
Diseases : Seizures
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Lights for epilepsy: can photobiomodulation reduce seizures and offer neuroprotection?Jun 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2023 Jul ;18(7):1423-1426. PMID: 36571337
Article Published Date : Jun 30, 2023
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Anticonvulsants
[+]

Mechanism of Curcuma longa and its neuroactive components for the management of epileptic seizures.May 16, 2021

Pubmed Data : Curr Neuropharmacol. 2021 May 17. Epub 2021 May 17. PMID: 33998991
Article Published Date : May 16, 2021
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Antioxidants
[+]

Neurobiological effects of gastrodin and its possible use in neurology and psychiatry.Dec 31, 2021

Pubmed Data : Zh Nevrol Psikhiatr Im S S Korsakova. 2022 ;122(8):27-34. PMID: 36036400
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Gastrodin
Diseases : Alzheimer's Disease, Depression, Epilepsy, Learning disorders, Stroke
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Phytocannabinoids produce anticonvulsant effects through the endocannabinoid system, with few adverse effects.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Pharm Ther. 2015 Apr ;40(2):135-43. Epub 2014 Dec 4. PMID: 25475762
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Cannabidiol, Cannabinoids
Diseases : Epilepsy, Epileptic Seizures
Pharmacological Actions : Anticonvulsants
Additional Keywords : Natural Substance/Drug Synergy, Natural Substances Versus Drugs
[+]

Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa).Sep 30, 2016

Pubmed Data : Chin J Nat Med. 2016 Oct ;14(10):732-745. Epub 2016 Oct 31. PMID: 28236403
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Substances : Nigella sativa (aka Black Seed)
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Anticonvulsants, Antihypertensive Agents, Antimicrobial, Antioxidants, Chemotherapeutic, Hypoglycemic Agents, Hypolipidemic
Additional Keywords : Analgesics, Anti-Inflammatory Agents, Anticonvulsants, Antihypertensive Agents, Antimicrobial, Antioxidants, Chemotherapeutic, Nigella sativa (aka Black Seed), Plant Extracts
[+]

Plantago subulate compounds are promising candidates for treating disorders like Alzheimer's disease, diabetes mellitus, glaucoma, leukemia, and epilepsy.Jul 31, 2022

Pubmed Data : Chem Biodivers. 2022 Aug ;19(8):e202200280. Epub 2022 Jul 7. PMID: 35796520
Article Published Date : Jul 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Plantago
Diseases : Alzheimer's Disease, Epilepsy, Glaucoma, Hyperglycemia, Leukemia
Pharmacological Actions : Acetylcholinesterase Inhibitor, Anticonvulsants, Antioxidants, Enzyme Inhibitors, Hypoglycemic Agents, Neuroprotective Agents
[+]

Possible involvement of PPAR-γ in the anticonvulsant effect of Aegle marmelos.Jul 31, 2013

Pubmed Data : Neurochem Res. 2013 Aug ;38(8):1624-31. Epub 2013 May 5. PMID: 23645163
Article Published Date : Jul 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Bael
Diseases : Depression, Epilepsy
Pharmacological Actions : Anticonvulsants, Antidepressive Agents
[+]

Potential therapeutic and pharmacological effects of Wogonin.Nov 30, 2020

Pubmed Data : Mol Biol Rep. 2020 Dec ;47(12):9779-9789. Epub 2020 Nov 9. PMID: 33165817
Article Published Date : Nov 30, 2020
Study Type : Review
Additional Links
Substances : Wogonin
Diseases : Anxiety, Inflammation
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Anticonvulsants, Antiviral Agents, Neuroprotective Agents
[+]

Prospects of cannabidiol for easing status epilepticus-induced epileptogenesis and related comorbidities.Jan 24, 2018

Pubmed Data : Mol Neurobiol. 2018 Jan 25. Epub 2018 Jan 25. PMID: 29372545
Article Published Date : Jan 24, 2018
Study Type : Review
Additional Links
Substances : Cannabidiol
Diseases : Brain Inflammation , Epilepsy
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants
[+]

Resveratrol has the potential to be a new antiepileptic treatment. Dec 31, 2014

Pubmed Data : Future Med Chem. 2015 ;7(15):2005-18. Epub 2015 Oct 27. PMID: 26505553
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Resveratrol
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants, Neuroprotective Agents
[+]

Rosa damascena as a holy ancient herb with novel applications.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2016 Jan ;6(1):10-6. Epub 2015 Oct 30. PMID: 26870673
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Rose , Rose: Essential Oil
Diseases : Bacillus Cereus infection, Cancers: All, Candida Albicans, Escherichia coli Infections, HIV Infections, Pseudomonas aeruginosa, Pseudomonas fluorescens infections, Staphylococcus aureus infection, Staphylococcus epidermidis
Pharmacological Actions : Analgesics, Anti-Bacterial Agents, Anticonvulsants, Antidepressive Agents, Antimicrobial, Antioxidants, Apoptotic, Cell cycle arrest
Additional Keywords : Plant Extracts
[+]

Rosmarinic acid is able to reduce cell damage generated by the 4-aminopyridine and picrotoxin seizures.Jan 10, 2019

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 11 ;392(11):1347-1358. Epub 2019 Jun 14. PMID: 31201429
Article Published Date : Jan 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Rosemaric Acid
Diseases : Epilepsy, Seizures
Pharmacological Actions : Anticonvulsants, Antioxidants, Neuroprotective Agents
[+]

The ketogenic diet leads to increases in circulating ketones, which may contribute to the efficacy in treating pharmacoresistant seizures.Jan 21, 2016

Pubmed Data : Cold Spring Harb Perspect Med. 2016 Jan 22. Epub 2016 Jan 22. PMID: 26801895
Article Published Date : Jan 21, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

The potential of cannabichromene (CBC) as a therapeutic agent.May 21, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Exp Ther. 2024 May 22. Epub 2024 May 22. PMID: 38777605
Article Published Date : May 21, 2024
Study Type : Review
Additional Links
Substances : Cannabichromene
Diseases : Epilepsy, Inflammation
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Anticonvulsants, Antinoceceptive
[+]

The sour side of vitamin C might mediate neuroprotective, anticonvulsive and antidepressant-like effects.Sep 30, 2019

Pubmed Data : Med Hypotheses. 2019 Oct ;131:109320. Epub 2019 Jul 20. PMID: 31443769
Article Published Date : Sep 30, 2019
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Depression
Pharmacological Actions : Anticonvulsants, Antidepressive Agents, Neuroprotective Agents
[+]

There is now concrete evidence to suggest the efficacy of cannabis in the treatment of epilepsy, particularly in the refractory group.Jan 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Isr Med Assoc J. 2017 Feb ;19(2):76-78. PMID: 28457054
Article Published Date : Jan 31, 2017
Study Type : Review
Additional Links
Substances : Cannabidiol, Cannabis
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

There is preliminary evidence that non-psychoactive cannabinoids may be useful as anticonvulsants.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Expert Opin Pharmacother. 2015 ;16(13):1911-4. Epub 2015 Aug 3. PMID: 26234319
Article Published Date : Dec 31, 2014
Study Type : Commentary
Additional Links
Substances : Cannabinoids
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

These substances have promising results in patients with pharmacoresistant epilepsies.Jan 31, 2017

Pubmed Data : Epilepsia. 2017 Feb ;58(2):181-221. Epub 2017 Jan 23. PMID: 28111749
Article Published Date : Jan 31, 2017
Study Type : Review
Additional Links
Substances : Cannabidiol, Cannabidivarin
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

This proposes the use of the ketogenic diet as an effective and efficient preliminary and long-term treatment.Sep 27, 2016

Pubmed Data : Amino Acids. 2016 Sep 28. Epub 2016 Sep 28. PMID: 27683025
Article Published Date : Sep 27, 2016
Study Type : Review
Additional Links
Diseases : Seizures
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

This review discusses the chemical constituents of Brahmi along with in vitro and in vivo studies based on its pharmacological effects.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:44. Epub 2016 Mar 4. PMID: 26973531
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Bacopa
Diseases : Alzheimer's Disease, Depression, Parkinson's Disease, Schizophrenia, Stroke
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Anticonvulsants, Antidepressive Agents, Antioxidants, Cytoprotective, Neuroprotective Agents
Additional Keywords : Risk Reduction
[+]

This review summarizes the history of the KD and the principles and efficacy of the classic ketogenic diet.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arq Neuropsiquiatr. 2016 Oct ;74(10):842-848. PMID: 27759811
Article Published Date : Sep 30, 2016
Study Type : Review
Additional Links
Diseases : Epilepsy
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Anticonvulsants
[+]

This review summarizes the scientific data on the major cannabinoids which have been of interest in the treatment of epilepsy.Sep 03, 2017

Pubmed Data : Expert Rev Neurother. 2017 Sep 4:1-11. Epub 2017 Sep 4. PMID: 28845714
Article Published Date : Sep 03, 2017
Study Type : Review
Additional Links
Substances : Cannabidiol, Cannabidivarin, Cannabinoids
Diseases : Epilepsy
Pharmacological Actions : Anticonvulsants
[+]

Vitex negundo induces an anticonvulsant effect by inhibiting voltage gated sodium channels in murine Neuro 2A cell line.Dec 31, 2017

Pubmed Data : Pak J Pharm Sci. 2018 Jan ;31(1(Suppl.)):297-303. PMID: 29386157
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Vitex negundo
Diseases : Epilepsy
Pharmacological Actions : Analgesics, Anticonvulsants
[+]

Yellow Himalayan raspberry ethnomedicinal, nutraceutical, and pharmacological aspects.Aug 14, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2023 Aug 15 ;28(16). Epub 2023 Aug 15. PMID: 37630323
Article Published Date : Aug 14, 2023
Study Type : Review
Additional Links
Substances : Anthocyanins, Raspberry
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Infective Agents, Anti-Inflammatory Agents, Anticonvulsants, Antioxidants, Renoprotective

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Written by Annemarie Colbin, Ph.D.
Our scientific dogma says that the latest research is the closest to the truth; yet as soon as new research comes out, it will be obsolete. This paradigm always ignores context. For example, for the past 15 years it has become assumed truth that a low fat diet is a healthy diet. The same people who thirty years ago used to urge us to eat plenty of meat and cheese, shifted to encourage us towards vegetables and low fat salad dressings

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