Anticonvulsants

Name	AC	CK
Cannabidiol	67	385
Melatonin	4	35
Omega-3 Fatty Acids	2	30
Cannabis	6	25
Curcumin	12	23
Vitamin B-12	3	22
Gastrodin	6	19
Citicoline	5	18
Peony	3	14
Berberine	5	10
Cannabinoids	8	10
Evening Primrose Oil	1	10
Folate	1	10
Flavonoids	5	9
Rose	4	7
Bacopa	4	6
Huperzine	4	6
Nigella sativa (aka Black Seed)	4	6
Piperine	3	6
Delta-tetrahydrocannabinol (THC)	2	5
Beta-Caryophyllene	2	4
Cannabidivarin	3	4
Ellagic Acid	2	4
Ginsenosides	2	4
Jujube	2	4
Lemongrass	2	4
Nutmeg	2	4
Palmitoylethanolamide	2	4
Passion Flower	2	4
Passion fruit	2	4
Pterostilbene	2	4
Royal Jelly	2	4
Sinomenine	2	4
Tanshinone IIA	2	4
Valerian	2	4
Moringa oleifera	1	3
Resveratrol	2	3
Rosemaric Acid	2	3
Vinpocetine	1	3
Acai	1	2
Arginine	1	2
Ashwagandha	1	2
Asiatic Acid	1	2
Asparagus	1	2
Astaxanthin	1	2
Baicalein	1	2
Banana Stem	1	2
Basil	1	2
Bay leaf	1	2
Biochanin A	1	2
Bitter Apple	1	2
Bitter Orange	1	2
Butterfly Pea	1	2
Cannabinoids: Synthetic	1	2
Carnosine	1	2
Chrysin	1	2
Coenzyme Q10	1	2
Coriandrum sativum	1	2
Curcumin: Lipidated	1	2
Dill	1	2
Diosgenin	1	2
Echinacea	1	2
Elderberry	1	2
Eugenol	1	2
Fenugreek	1	2
Fig	1	2
Fisetin	1	2
Folic Acid	1	2
Geraniol	1	2
Globimetula Braunii	1	2
Henbane	1	2
Hesperidin	1	2
Hyssop	1	2
Icariin	1	2
Lavender	1	2
Linden (Tilia)	1	2
Lotus	1	2
Luteolin	1	2
Mulberry	1	2
Myo-inositol	1	2
NAC (N-acetyl-L-cysteine)	1	2
Nettle	1	2
Oleuropein	1	2
Oligosaccharides	1	2
Orthosiphon	1	2
Paeoniflorin	1	2
Pear	1	2
Peppermint	1	2
Phyllanthus emblica	1	2
Pine Needle	1	2
Poria cocos	1	2
Potato	1	2
Probiotics	1	2
Progesterone	1	2
Pycnogenol (Pine Bark)	1	2
Quercetin	1	2
Rutin	1	2
Safranal	1	2
Seaweed: Brown	1	2
Sesamin	1	2
Sesamol	1	2
Shilajit	1	2
Skullcap: Blue	1	2
Solanum nigrum (black nightshade)	1	2
Spikenard	1	2
Stigmasterol	1	2
Sulforaphane	1	2
Syrian rue	1	2
Tangeretin	1	2
Tarragon	1	2
Thyme	1	2
Thymoquinone	1	2
Turmeric	1	2
Turmerones	1	2
Vitamin D	1	2
Vitexins	1	2
Zataria multiflora	1	2
ibogaine	1	2
Anthocyanins	1	1
Bael	1	1
Cannabichromene	1	1
Plantago	1	1
Raspberry	1	1
Reishi Mushroom	1	1
Rose: Essential Oil	1	1
Saffron	1	1
Vitamin C	1	1
Vitex negundo	1	1
Wogonin	1	1

Diseases : Epilepsy

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Anticonvulsants

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Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients.Jan 31, 2023

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Pubmed Data : Brain Behav. 2023 Feb ;13(2):e2860. Epub 2023 Jan 1. PMID: 36588283

Article Published Date : Jan 31, 2023

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

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Effect of cannabidiol on interictal epileptiform activity and sleep architecture in children with intractable epilepsy.Jan 10, 2021

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Pubmed Data : Epilepsia. 2023 May 26. Epub 2023 May 26. PMID: 37243404

Article Published Date : May 25, 2023

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

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Eighty five percent of all parents reported a reduction in seizure frequency and 14% reported complete seizure freedom.Apr 28, 2015

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Pubmed Data : Epilepsy Behav. 2015 Apr 29. Epub 2015 Apr 29. PMID: 25935511

Article Published Date : Apr 28, 2015

Study Type : Human Study

Additional Links

Substances : Cannabidiol, Cannabis

Diseases : Epilepsy, Epilepsy: Childhood

Pharmacological Actions : Anticonvulsants

Additional Keywords : Plant Extracts

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Evening primrose is safe, and may have therapeutic action for epileptics.Aug 01, 2007

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Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 2007 Aug;77(2):101-3. Epub 2007 Aug 30. PMID: 17764919

Article Published Date : Aug 01, 2007

Study Type : Human Study

Additional Links

Substances : Evening Primrose Oil

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

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Pubmed Data : Seizure. 2017 Jul 11 ;51:1-5. Epub 2017 Jul 11. PMID: 28743048

Article Published Date : Jul 10, 2017

Study Type : Human Study

Additional Links

Diseases : Encephalopathy, Seizures

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Anticonvulsants

Additional Keywords : Significant Treatment Outcome

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The ketogenic diet significantly improves quality of life, and reduces both seizures and medication needs in most patients wtih Dravet syndrome studied.Sep 01, 2005

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Pubmed Data : Epilepsia. 2005 Sep;46(9):1539-44. PMID: 16146451

Ketogenic diet attenuates refractory epilepsy of Harel-Yoon Syndrome with ATAD3A variants.May 31, 2023

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Pubmed Data : Pediatr Neurol. 2023 Jun ;143:79-83. Epub 2023 Mar 9. PMID: 37031571

Article Published Date : May 31, 2023

Study Type : Human: Case Report, Review

Additional Links

Diseases : Epilepsy

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic

Pharmacological Actions : Anticonvulsants

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Report of a 6-month-old Asian infant with early infantile epileptic encephalopathy whose seizures were eliminated by cannabidiol.Dec 31, 2019

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Pubmed Data : Epilepsy Behav Rep. 2020 ;14:100373. Epub 2020 Jun 8. PMID: 32695984

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An ethanol extract of Glycyrrhiza glabra poses anti-convulsant potential and ameliorates ROS induced neuronal damage in PTZ-induced seizure.Dec 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Indian J Pharmacol. 2013 Jan-Feb;45(1):40-3. PMID: 23543836

Article Published Date : Dec 31, 2012

Study Type : Animal Study

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Diseases : Oxidative Stress, Seizures

Pharmacological Actions : Anticonvulsants, Antioxidants, Malondialdehyde Down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

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An extract of Globimetula braunii leaves possesses psychoactive compound that may be useful in the management of petit mal epilepsy.Mar 31, 2014

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Pubmed Data : Asian Pac J Trop Biomed. 2014 Apr ;4(4):285-9. PMID: 25182552

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Pubmed Data : Neurochem Res. 2023 Jul ;48(7):2187-2195. Epub 2023 Mar 1. PMID: 36856963

Article Published Date : Jun 30, 2023

Study Type : Animal Study

Additional Links

Substances : Royal Jelly

Diseases : Epilepsy, Seizures

Pharmacological Actions : Anticonvulsants, Antioxidants

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Bacopa monnieri exhibited anti-seizure activity.Feb 28, 2021

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Pubmed Data : Afr Health Sci. 2008 Jun;8(2):74-9. PMID: 19357754

Article Published Date : Jun 01, 2008

Study Type : Animal Study

Additional Links

Substances : Solanum nigrum (black nightshade)

Diseases : Seizures

Pharmacological Actions : Anticonvulsants

Additional Keywords : Plant Extracts

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Blue skullcap (S. lateriflora) has anticonvulsant activity. May 01, 2009

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Pubmed Data : Phytomedicine. 2009 May;16(5):485-93. Epub 2008 Sep 10. PMID: 18786819

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Pubmed Data : Pharmacol Biochem Behav. 2003 Jun ;75(3):529-36. PMID: 12895670

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Dose dependent anticonvulsant activity of Morus nigra in strychnine induced seizures model.Oct 31, 2021

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Pubmed Data : Pak J Pharm Sci. 2021 Nov ;34(6):2167-2171. PMID: 35034877

Article Published Date : Oct 31, 2021

Study Type : Animal Study

Additional Links

Substances : Mulberry

Diseases : Seizures

Pharmacological Actions : Anticonvulsants

Additional Keywords : Dose Response, Plant Extracts

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Dual protective effect of Passiflora incarnata in epilepsy and associated post-ictal depression.Jan 05, 2012

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Pubmed Data : J Ethnopharmacol. 2012 Jan 6 ;139(1):273-9. Epub 2011 Nov 15. PMID: 22107833

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Pubmed Data : Epilepsy Res. 2021 10 ;176:106723. Epub 2021 Jul 12. PMID: 34304017

Article Published Date : Jan 09, 2021

Study Type : Animal Study

Additional Links

Substances : Probiotics

Diseases : Seizures

Pharmacological Actions : Anticonvulsants, Gastrointestinal Agents

Additional Keywords : Natural Substance/Drug Synergy

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Elderberry extracts have multiple mechanisms for its anticonvulsant actions.Jun 30, 2016

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2016 Jul ;20(14):3123-6. PMID: 27460744

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Elderberry

Diseases : Epilepsy, Epilepsy: Drug-Induced, Seizures

Pharmacological Actions : Anticonvulsants

Additional Keywords : Plant Extracts

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Emblica officnalis protects against drug-induced seizures, oxidative stress and cognitive impairment in rats.May 01, 2010

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Pubmed Data : Indian J Exp Biol. 2010 May;48(5):474-8. PMID: 20795364

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Pubmed Data : BMC Complement Med Ther. 2023 Nov 3 ;23(1):393. Epub 2023 Nov 3. PMID: 37924049

Article Published Date : Nov 02, 2023

Study Type : Animal Study

Additional Links

Substances : Basil

Diseases : Seizures

Pharmacological Actions : Anticonvulsants, Gastrointestinal Agents

Additional Keywords : Gut-brain Axis

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Henbane exhibits anticonvulsive activity against picrotoxin-induced seizure.Jul 01, 2009

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Pubmed Data : Pak J Pharm Sci. 2009 Jul;22(3):308-12. PMID: 19553180

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Pubmed Data : Neuropharmacology. 2015 Aug 6 ;99:500-509. Epub 2015 Aug 6. PMID: 26256422

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Pubmed Data : BMC Complement Altern Med. 2007 Aug 8 ;7:26. Epub 2007 Aug 8. PMID: 17686156

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Results showed that ellagic acid increased the seizure threshold and decreased the expression of Nr2a and Nr2b. Dec 31, 2021

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Pubmed Data : Epilepsy Behav. 2016 09 ;62:27-34. Epub 2016 Jul 20. PMID: 27448240

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Rosemaric Acid

Diseases : Seizures: Drug-Induced

Pharmacological Actions : Anticonvulsants

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Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice.Jan 01, 2018

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Pubmed Data : Pharmazie. 2018 04 2 ;73(4):207-212. PMID: 29609687

Article Published Date : Jan 01, 2018

Study Type : Animal Study

Additional Links

Substances : Safranal

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants

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Pubmed Data : Phytomedicine. 2021 Jun 30 ;90:153646. Epub 2021 Jun 30. PMID: 34280827

Article Published Date : Jun 29, 2021

Study Type : Animal Study

Additional Links

Substances : Stigmasterol

Diseases : Anxiety, Epilepsy

Pharmacological Actions : Anti-Anxiety Agents, Anticonvulsants, GABA Modulators

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Subchronic administration of palmitoylethanolamide significantly alleviates seizure intensity, promotes neuroprotection.Dec 31, 2017

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Pubmed Data : Pharm Biol. 2023 Dec ;61(1):100-110. PMID: 36548216

Article Published Date : Nov 30, 2023

Study Type : Animal Study

Additional Links

Substances : Tanshinone IIA

Diseases : Epilepsy

Pharmacological Actions : Anticonvulsants, Neuroprotective Agents

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Tarragon (Artemisia d.) essential oil has anticonvulsant activity, confirming its traditional use in Iranian folkloric medicine.Feb 15, 2008

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Pubmed Data : Clin Cancer Res. 2008 Feb 15;14(4):1248-57. PMID: 15325732

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Trigonelline as an anticonvulsant agent: mechanistic insights into NMDA receptor expression and oxidative stress balance.Jun 19, 2024

Pubmed Data : Patol Fiziol Eksp Ter. 2016 ;60(4):20-3. PMID: 29244918

An overview of the preclinical pharmacological properties of Nigella sativa.Nov 30, 2016

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Pubmed Data : J Physiol Pharmacol. 2016 Dec ;67(6):801-817. PMID: 28195061

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Pubmed Data : Epilepsy Behav. 2009 Aug;15(4):529-34. Epub 2009 Jul 17. PMID: 19616481

Article Published Date : Aug 01, 2009

Study Type : Commentary

Additional Links

Substances : Huperzine

Diseases : Seizures

Pharmacological Actions : Anticonvulsants, Neuroprotective Agents

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Lights for epilepsy: can photobiomodulation reduce seizures and offer neuroprotection?Jun 30, 2023

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Pubmed Data : J Clin Pharm Ther. 2015 Apr ;40(2):135-43. Epub 2014 Dec 4. PMID: 25475762

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Pubmed Data : J Tradit Complement Med. 2016 Jan ;6(1):10-6. Epub 2015 Oct 30. PMID: 26870673

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Pubmed Data : Front Pharmacol. 2016 ;7:44. Epub 2016 Mar 4. PMID: 26973531

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Substances : Bacopa

Diseases : Alzheimer's Disease, Depression, Parkinson's Disease, Schizophrenia, Stroke

Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Anticonvulsants, Antidepressive Agents, Antioxidants, Cytoprotective, Neuroprotective Agents

Additional Keywords : Risk Reduction

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This review summarizes the history of the KD and the principles and efficacy of the classic ketogenic diet.Sep 30, 2016

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View the Evidence: 270 Abstracts with Anticonvulsants Research

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This systematic review found that add-on melatonin therapy improved sleep latency and seizure severity in patients with epilepsy.Feb 22, 2024

A review and meta-analysis of the efficacy and safety of cannabidiol in epilepsy.Nov 02, 2018

Adjunctive CBD resulted in a greater reduction in convulsive seizure frequency.Feb 09, 2020

Ketogenic diet for epilepsy: an overview of systematic review and meta-analysis.Jan 12, 2022

Omega-3 supplementation resulted in beneficial effects on seizure frequency in adult and children with epilepsy.Jul 29, 2021

A combination of gastrodin, folate, and vitamin-B12 in addition to standard antiepileptic treatment can effectively control epileptic seizures.Oct 31, 2017

A ketogenic diet has anticonvulsant and neuroprotective effects. Jan 01, 2010

Acupuncture has therapeutic value in the treatment of acute herpes zoster pain. Jan 01, 2009

Add-on cannabidiol may be an efficacious long-term treatment option for treatment-resistant epilepsies.Jul 11, 2018

Artisanal cannabidiol-enriched cannabis may be an effective and safe long-term treatment for refractory epilepsy.Jun 27, 2022

Beyond seizure control, patients experienced a marked improvement in behavior and awareness. Dec 01, 2019

Cannabidiol as an adjuvant treatment in adults with drug-resistant focal epilepsy.Jun 30, 2023

Cannabidiol for treating Lennox-Gastaut Syndrome and Dravet Syndrome in Korea Dec 27, 2020

Cannabidiol improves frequency and severity of seizures and reduces adverse events.Aug 08, 2018

Cannabidiol in children with treatment-resistant epilepsy with myoclonic-atonic seizures.May 31, 2023

Cannabidiol may be an effective and well-tolerated treatment option for patients with refractory seizures in Tuberous sclerosis complex.Sep 30, 2016

Cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with treatment-resistant epilepsy.Dec 22, 2015

Cannabidiol reduced the frequency of both focal and generalised seizures with 50 % seizure reduction in 76 % of the cohort.Jun 20, 2024

Cannabidiol resulted in a greater reduction in convulsive-seizure frequency among patients with Dravet syndrome.Jan 24, 2017

Cannabidiol treatment in children with treatment resistant epilepsies led to 42% of children reporting a greater than 80% reduction in seizure frequency and 32% reporting a 25-60% seizure reduction.Nov 30, 2013

Cannabidiol treatment yielded a significant positive effect on seizure load in patients with intractable epilepsy.Jan 05, 2016

Cannabidiol-enriched oil for adult patients with drug-resistant epilepsy.May 28, 2024

CBD could be beneficial for the treatment of brain tumor-related epilepsy.Oct 23, 2017

CBD was found to have potential benefits as add-on therapy for refractory childhood epilepsies.Mar 07, 2018

Citicoline could be a promising neuroprotector drug in neonates with hypoxic-ischemic encephalopathy.May 11, 2023

Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients.Jan 31, 2023

Effect of cannabidiol on interictal epileptiform activity and sleep architecture in children with intractable epilepsy.Jan 10, 2021

Effectiveness of cannabidiol in a prospective cohort of children with drug-resistant epileptic encephalopathy.Jun 05, 2020

Efficacy and tolerability of hydroalcoholic extract of Paeonia officinalis in children with intractable epilepsy.Sep 30, 2021

Efficacy and tolerance of cannabidiol in the treatment of epilepsy in patients with Rett syndrome.Jul 23, 2023

Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment-resistant epilepsies.May 25, 2023

Eighty five percent of all parents reported a reduction in seizure frequency and 14% reported complete seizure freedom.Apr 28, 2015

Evening primrose is safe, and may have therapeutic action for epileptics.Aug 01, 2007

Highly purified cannabidiol in the treatment of drug-resistant epilepsies.Sep 30, 2023

Ketogenic diet is an effective and safe non-pharmacologic, non-surgical therapy for the management of drug-resistant epilepsy.Nov 30, 2023

Ketogenic diet is an important non-pharmacological treatment option for patients with intractable epilepsy associated with tuberous sclerosis complex.May 31, 2017

Long-term add-on CBD treatment had an acceptable safety profile in patients with Lennox-Gastaut syndrome and led to sustained reductions in seizures.Feb 10, 2019

Long-term efficacy and safety of cannabidiol in patients with treatment-resistant epilepsies.Feb 28, 2023

Music had beneficial effects on seizure frequency in institutionalized subjects with severe intellectual disability and drug-resistant epilepsy.Aug 31, 2017

Omega-3 fatty acids may be useful in the prevention and treatment of epilepsy. Aug 27, 2009

Purified pharmaceutical CBD may be an effective and safe adjunctive therapy in refractory epileptic spasms.Mar 09, 2020

Six months after initiating the ketogenic diet it led to a 50% reduction in seizure frequency in those that responded to the diet. Oct 31, 2015

Successful treatment of intractable epilepsy with ketogenic diet therapy in twins with ALG3-CDG.May 06, 2020

The ketogenic diet appeared to be an effective therapeutic modality for intractable pediatric epilepsy in tuberous sclerosis complex.Apr 28, 2020

The ketogenic diet could be implemented in medium resources countries and should be included in the management of children with intractable epilepsy.Dec 31, 2018

The ketogenic diet is a promising therapy for myoclonic status in non-progressive encephalopathy.Jul 10, 2017

The ketogenic diet significantly improves quality of life, and reduces both seizures and medication needs in most patients wtih Dravet syndrome studied.Sep 01, 2005

The ketogenic diet was beneficial for patients with GLUT-1 deficiency syndrome.Jan 13, 2016

The results show that the ketogenic diet is effective in Lennox-Gastaut syndrome.Nov 30, 2016

The results suggest that CBD may have beneficial effects on patient quality of life, distinct from its seizure-reducing effects.Jun 14, 2017

These findings support efficacy of artisanal CBD preparations in seizure reduction with few significant side effects.Feb 07, 2018

This study suggests that cannabidiol may be well tolerated as adjunctive medication for seizure management.Feb 21, 2017

This work further confirms the anticonvulsant efficacy of CBD and supports its application in the treatment of human seizure disorders.Jun 14, 2017

Three to 6 years after initiation, the ketogenic diet had proven to be effective in the control of difficult-to-control seizures in children.Sep 30, 2001

Treatment with ketogenic diet resulted in a marked improvement in seizures and cognitive functions.Sep 30, 2015

Vitamin B12 is superior to the drug Nortriptyline in the treatment of diabetic neuropathy.Jan 01, 2009

Ketogenic diet attenuates refractory epilepsy of Harel-Yoon Syndrome with ATAD3A variants.May 31, 2023

Report of a 6-month-old Asian infant with early infantile epileptic encephalopathy whose seizures were eliminated by cannabidiol.Dec 31, 2019

"Efficacy of the ketogenic diet for intractable seizure disorders: review of 58 cases."Oct 31, 1992

A 10-month-old boy with malignant migrating partial seizures in infancy made developmental gains and sustained seizure reduction with the addition of cannabidiol to his antiepileptic regimen.Apr 30, 2015

Ameliorative effect of ethanolic extract of Moringa oleifera leaves in combination with curcumin against PTZ-induced kindled epilepsy.Aug 29, 2023

Effectiveness of highly purified cannabidiol in refractory and super-refractory status epilepticus.Jun 20, 2024

Potential role of cannabidiol for seizure control in a patient with recurrent glioma.Dec 13, 2019

Precision medicine: Vinpocetine as a potential treatment for GABRG2-related epilepsy.May 31, 2023

Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus.Dec 31, 2017

These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Dec 31, 2015

CBD exhibits anti-seizure properties in acute seizure models.May 05, 2017

A hydro-alcoholic extract of Dill seed demonstrated anticonvulsant activity against PTZ-induced seizures.Dec 31, 2013

A hydro-alcoholic extract of R. dam ascena has anticonvulsant and neuroprotective effects.Apr 30, 2015

An ethanol extract of Glycyrrhiza glabra poses anti-convulsant potential and ameliorates ROS induced neuronal damage in PTZ-induced seizure.Dec 31, 2012

An extract of Globimetula braunii leaves possesses psychoactive compound that may be useful in the management of petit mal epilepsy.Mar 31, 2014

Anti-inflammation associated protective mechanism of berberine and its derivatives on attenuating pentylenetetrazole-induced seizures.Jan 05, 2020

Anticonvulsants

View the Evidence:
270 Abstracts with Anticonvulsants Research