Antineoplastic Agents

Name	AC	CK
Curcumin	290	402
Flavonoids	59	82
Fucoidan	43	52
Ginsenosides	33	40
Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine)	6	37
Genistein	14	36
Isoflavones	11	31
Resveratrol	28	31
Ginger	8	29
Polyphenols	19	25
Homeopathic Medicine: All	5	24
Quercetin	12	23
Sulforaphane	15	23
Antineoplastons	9	22
Calcium	2	22
Reishi Mushroom	12	22
Thymoquinone	14	22
Lactoferrin	16	21
Shitake Mushroom	2	21
Beta-Elemene	17	20
Calendula	1	20
Homeopathic Medicine: Traumeel	1	20
Magnesium	1	20
Pycnogenol (Pine Bark)	2	20
Turmeric	8	19
Cannabidiol	13	18
Xanthohumol	15	18
Artemisinin	14	17
Cannabinoids	14	17
Mistletoe	4	16
Vitamin C	12	16
Berberine	7	15
Daidzein	5	15
EGCG (Epigallocatechin gallate)	12	15
Silibinin	6	15
Deguelin	12	14
Licorice	11	14
Luteolin	10	14
Vitamin E	5	14
Artesunate	4	13
Catechin	12	12
Cryptoxanthin	2	12
Cucurbitacin B	7	12
Lycopene	3	12
NAC (N-acetyl-L-cysteine)	6	12
Omega-3 Fatty Acids	3	12
Solasodine glycoalkaloids	2	12
Anthocyanins	8	11
Carotenoids	2	11
Gallic Acid	11	11
Garlic	10	11
Grape Seed Extract	6	11
Oridonin	10	11
Tannic Acid	7	11
Vitamin B-12	2	11
White Button Mushroom	2	11
Andrographis	10	10
Apigenin	8	10
Caffeine	1	10
Folic Acid	1	10
Honey: Life Mel Proprietary Formula	1	10
Indole-3-Carbinol	9	10
Melatonin	8	10
Mulberry	8	10
Parthenolide	9	10
Soy	1	10
Aloe Vera	5	9
Amla Fruit	3	9
Bee Venom	8	9
Myricetin	9	9
Salvia miltiorrhiza	8	9
Tocotrienol: Gamma	5	9
Bromelain	4	8
Cannabinoids: Synthetic	5	8
Cannabis	4	8
Chaga Mushroom (Inonotus obliquus)	7	8
Elecampane	8	8
Fisetin	6	8
Fucoxanthin	4	8
Ginkgo biloba	6	8
Gold (nanoparticles)	7	8
Lichens	8	8
Paeonol	6	8
Vitamin D	7	8
Vitamin K	7	8
Betulinic acid	7	7
Capsaicin	3	7
Delta-tetrahydrocannabinol (THC)	5	7
Ellagic Acid	6	7
Fermented Foods and Beverages	3	7
Huaier (Trametes robiniophila murr)	6	7
Naringenin	6	7
Nigella sativa (aka Black Seed)	3	7
Oyster Mushroom	6	7
Pterostilbene	5	7
Stilbenes	7	7
Wheat Germ	3	7
6-Shogaol	5	6
Allicin	5	6
Babchi	5	6
Benzyl isothiocyanate	5	6
Carbon 60	3	6
Carnosol	5	6
Diosgenin	6	6
Emodin	6	6
Flaxseed	3	6
Green Tea	3	6
Lignans	3	6
Papaya	2	6
Shikonin	5	6
Sinomenine	4	6
Sweet Potato	2	6
Tanshinone IIA	6	6
Achiote	1	5
Amurensin G	1	5
Ashwagandha	3	5
DHA (Docosahexaenoic Acid)	4	5
Formononetin	5	5
Germanium	3	5
Horse Chestnut	3	5
Isoliquiritigenin	5	5
Isothiocyanates	4	5
Kaempferol	4	5
Mangiferin	3	5
Medicinal Mushrooms	5	5
Moringa oleifera	4	5
Oleuropein	4	5
Papaya: Fermented	1	5
Patchouli	3	5
Phlorotannins	5	5
Piperidines	3	5
Piperlongumine	5	5
Seaweed: Brown	5	5
Sesamin	1	5
Tocotrienols	1	5
Vitamin C: Intravenous	1	5
Vitamin E: alpha tocopherol	3	5
Whey	4	5
Adlay	3	4
Andrographolide	4	4
Antineoplaston A3	2	4
Antineoplaston A5	2	4
Asiatic Acid	4	4
Baicalein	2	4
Caffeic acid phenethyl ester	3	4
Carnosic Acid	3	4
Catechols	2	4
Citral	3	4
D-Limonene	3	4
Enterodiol	2	4
Enterolactone	2	4
Fenugreek	4	4
Gold	3	4
Graviola	2	4
Inositol Hexaphosphate	3	4
Lotus	3	4
Nobiletin	3	4
Nordihydroguaiaretic acid (NDGA)	3	4
Olive	4	4
Organosulfur Compounds	4	4
Phellinus Linteus	3	4
Phenethyl isothiocyanate	3	4
Piceatannol	4	4
Poria cocos	3	4
Rosemary	4	4
Seaweed	4	4
Soy Protein	2	4
Syringic Acid	2	4
Tea	3	4
Terminalia	2	4
Zerumbone	3	4
phytoestrogens	2	4
Agaricus Blazei	2	3
Antrodia camphorata	2	3
Astragaloside	3	3
Bee Propolis	3	3
Berbamine	2	3
Beta Sitosterol	3	3
Biochanin A	3	3
Black Pepper	2	3
Black Raspberry	2	3
Bufalin	3	3
Caffeic Acid	3	3
Carvacrol	2	3
Chlorella (Algae)	2	3
Collagen	2	3
Colloidal Silver	3	3
Curcumol	3	3
Curry Spice	2	3
Delphinidin	3	3
Eugenol	3	3
Fig	2	3
Frankincense	3	3
Glycyrrhizin	3	3
Gynostemma	2	3
Honokiol	2	3
Hyaluronic Acid	1	3
Kava Kava	2	3
Liquiritigenin	2	3
MSM (Methylsulfonylmethane)	2	3
Modified Arabinoxylan Rice Bran (MGN-3)	2	3
Myrrh	3	3
Paeoniflorin	3	3
Panax Notoginseng	3	3
Panaxadiol	2	3
Peony	2	3
Phloretin	3	3
Phosphatidylcholine	2	3
Pleurotus nebrodensis	2	3
Pomegranate	3	3
Spinach	2	3
Tangeretin	2	3
Thunder god vine	1	3
Tomato	2	3
Vinpocetine	2	3
Vitamin A	2	3
Vitamin E: Gamma-tocotrienol	3	3
Vitamin K2	3	3
Wogonin	2	3
AHCC	1	2
Amygdalin	2	2
Anandamide	1	2
Angelica	1	2
Arctigenin	2	2
Arginine	1	2
Asafoetida	2	2
Asparagus	2	2
Astaxanthin	2	2
Bai Zhu	2	2
Bamboo	1	2
Bergamot	2	2
Bisdemethoxycurcumin	2	2
Bitter Melon	2	2
Cardamom	1	2
Chlorogenic Acid	2	2
Cholesterol	1	2
Chrysin	2	2
Copper	2	2
Cordyceps Militaris	2	2
Cruciferous Vegetables	1	2
Cucumber	1	2
Dandelion	2	2
Dates	1	2
Diosmetin	2	2
EPA (Eicosapentaenoic Acid)	1	2
False Daisy	1	2
Feverfew	2	2
Fiber	1	2
Galbanic Acid	2	2
Gingerol	2	2
Guava	2	2
Helenalin	2	2
Hibiscus	2	2
Hydroxytyrosol	2	2
Iodine	1	2
Juniper	1	2
Kefir	1	2
Leonurine	2	2
Lion's Mane (Hericium Erinaceus)	1	2
Magnolol	2	2
Mastic gum	1	2
Meadowsweet	1	2
Methionine	1	2
Mung Bean	1	2
Mushrooms: All	1	2
Myo-inositol	1	2
Neem	2	2
Oleanolic acid	1	2
Olive leaf extract	1	2
Oolong tea	1	2
Orange	1	2
Propolis: Brazillian	2	2
Red Yeast Rice	1	2
Rosemaric Acid	2	2
Rubia Cordifolia	1	2
Sage	1	2
Saikosaponin	2	2
Sesame Seeds	1	2
Shemamruthaa	1	2
Silver (nanoparticles)	2	2
Sprouts	1	2
Sweet Potato: Purple	1	2
Tart Cherry	1	2
Taurine	1	2
Testosterone	1	2
Tetrahydrocurcumin	2	2
Thistle	2	2
Toona sinensis	2	2
Traditional Chinese Medicine: Compound Kushen Injection	1	2
Ursolic Acid	2	2
Verbascoside	1	2
Walnut	2	2
Wasabi	1	2
beta-Carotene	2	2
Acai	1	1
Alpha-Lipoic Acid	1	1
Apple	1	1
Arachidonyl Ethanolamide (AEA)	1	1
Bael	1	1
Barberry	1	1
Bauhinia purpurea	1	1
Bay leaf	1	1
Bee Pollen	1	1
Bee Products	1	1
Beet	1	1
Bergamot orange	1	1
Beta-Caryophyllene	1	1
Beta-glucan	1	1
Betel	1	1
Birch	1	1
Bitter Orange	1	1
Bixin	1	1
Bloodroot	1	1
Boswellia	1	1
Broccoli	1	1
Canthaxanthin	1	1
Cardamonin	1	1
Carnosine	1	1
Cassava	1	1
Celastrol	1	1
Chia	1	1
Chinese Skullcap	1	1
Chlorophyll	1	1
Chrysanthemum Indicum	1	1
Citrus Triterpenoids	1	1
Citrus naringin	1	1
Clausena excavata	1	1
Cleavers	1	1
Coconut	1	1
Coconut Husk/Fiber	1	1
Cordyceps sinensis	1	1
Coumestrol	1	1
Crocin	1	1
Cucurbitacin D	1	1
Cucurbitacin E	1	1
Curcuma Comosa	1	1
Curcuminoids	1	1
Curry Leaves	1	1
Cyanidin	1	1
Cyanidin 3-glucoside	1	1
DHEA (Dehydroepiandrosterone)	1	1
Diallyl sulfide	1	1
Docosahexaenoic acid (DHA)	1	1
Echinacea	1	1
Eggplant	1	1
Endocannabinoids	1	1
Eriodictyol	1	1
Eucalyptus	1	1
Evening Primrose Oil	1	1
Evodiamine	1	1
False Black Pepper	1	1
Feijoa	1	1
Fennel	1	1
Ganoderma colossum	1	1
Garcinia indica	1	1
Genipin	1	1
Geraniol	1	1
Ginseng	1	1
Ginseng (American)	1	1
Gleditsia sinensis	1	1
Glycyrrhiza uralensis	1	1
Goldenseal	1	1
Goldenthread	1	1
Gotu Kola	1	1
Grape	1	1
Guarana	1	1
Harmine	1	1
Hawthorn	1	1
Hazelnut	1	1
Holy Basil	1	1
Honey	1	1
Honeysuckle	1	1
Hyperforin	1	1
King trumpet mushroom	1	1
Lactobacillus Acidophilus	1	1
Lactobacillus casei	1	1
Lactobacillus paracasei	1	1
Lemongrass	1	1
Loquat Leaves	1	1
Lupeol	1	1
Lutein	1	1
Lychee	1	1
Lysine	1	1
Marchantin C	1	1
Milk: Fermented	1	1
Modified Citrus Pectin	1	1
Mugwort	1	1
Mululuza	1	1
Nettle	1	1
Okra	1	1
Onion	1	1
Oyster Mushroom: Golden	1	1
P-Coumaric Acid	1	1
Parsley	1	1
Pea	1	1
Peach	1	1
Persimmon	1	1
Pheophorbide a (Chlorophyll Metabolite)	1	1
Phosphatidylserine	1	1
Pine Bark Extract	1	1
Plantago	1	1
Plum	1	1
Potato	1	1
Prickly Pear Cactus	1	1
Probiotics	1	1
Proline	1	1
Prunella vulgaris	1	1
Pueraria mirifica	1	1
Puerarin	1	1
Punicic acid	1	1
Quince	1	1
Red Marine Algae	1	1
Rose	1	1
Rose Hips	1	1
Roseoside	1	1
Royal Jelly	1	1
Safflower	1	1
Sea buckthorn	1	1
Sesamol	1	1
Shiitake Mushroom	1	1
Shilajit	1	1
Silymarin	1	1
Soup	1	1
Spermidine	1	1
Spirulina	1	1
Sumac	1	1
Tarragon	1	1
Theanine	1	1
Thyme	1	1
Thymol	1	1
Tomatidine	1	1
Traditional Chinese Medicine: Mylabris	1	1
Trichosanthes Kirilowii	1	1
Triphala	1	1
Tripterygium wilfordii	1	1
Triptolide	1	1
Turkey Tail Mushroom	1	1
Tyrosol	1	1
Vanadium	1	1
Venom: Snake	1	1
Viruses: Beneficial	1	1
Vitexins	1	1
Water: Deuterium Depleted	1	1
White Mulberry	1	1

[+]

Acupressure has therapeutic value for chemotherapy-induced nausea and vomiting.Jul 01, 2007

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Pubmed Data : Oncol Nurs Forum. 2007 Jul;34(4):813-20. PMID: 17723973

Article Published Date : Jul 01, 2007

Study Type : Meta Analysis

Additional Links

Diseases : Chemotherapy-Induced Nausea, Nausea

Therapeutic Actions : Acupressure

Pharmacological Actions : Antineoplastic Agents

[+]

Calcium and magnesium can lessen the incidence of oxaliplatin induced neuropathy.May 31, 2013

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Pubmed Data : J Dig Dis. 2013 Jun ;14(6):288-98. PMID: 23432969

Article Published Date : May 31, 2013

Study Type : Meta Analysis

Additional Links

Substances : Calcium, Magnesium

Diseases : Chemotherapy-Induced Toxicity: Oxaliplatin

Pharmacological Actions : Antineoplastic Agents, Chemoprotective Agents

Additional Keywords : Significant Treatment Outcome

[+]

Efficacy of biological response modifier lentinan with chemotherapy for advanced cancer: a meta-analysis.Sep 30, 2017

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Pubmed Data : Cancer Med. 2017 Oct ;6(10):2222-2233. Epub 2017 Sep 21. PMID: 28940986

Article Published Date : Sep 30, 2017

Study Type : Meta Analysis

Additional Links

Substances : Shitake Mushroom

Diseases : Cancers: All

Pharmacological Actions : Antineoplastic Agents, Chemotherapeutic

Additional Keywords : Polysaccharides

[+]

There is evidence to support the use of topical calendula for prophylaxis of acute dermatitis during radiotherapy and Traumeel S mouthwash in the treatment of chemotherapy-induced stomatitis. Jan 01, 2009

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Pubmed Data : Cochrane Database Syst Rev. 2009(2):CD004845. Epub 2009 Apr 15. PMID: 19370613

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Pubmed Data : Clin Cancer Res. 2015 Oct 1 ;21(19):4398-409. Epub 2015 May 28. PMID: 26023082

Article Published Date : Sep 30, 2015

Study Type : Animal Study, Human Study, In Vitro Study

Additional Links

Substances : Cryptoxanthin

Diseases : Colon Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin

[+]

Caffeine potentiates chemotherapy for metastatic osteosarcoma.Sep 01, 2009

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Pubmed Data : J Orthop Sci. 2009 Sep;14(5):556-65. Epub 2009 Oct 3. PMID: 19802667

Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea.Jun 30, 2012

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Pubmed Data : Ann Oncol. 2008 Jul ;19(7):1327-30. Epub 2008 Mar 17. PMID: 18349031

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Diseases : Lymphoma: Mantle Cell

Pharmacological Actions : Antineoplastic Agents

Additional Keywords : Drug: Doxorubicin

Anti Therapeutic Actions : Chemotherapy

Problem Substances : Chemotherapy

[+]

Lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer.Jul 01, 2009

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Pubmed Data : J Pharm Pharmacol. 2009 Jul;61(7):961-7. PMID: 17927495

Article Published Date : Jul 01, 2009

Study Type : Human Study

Additional Links

Substances : Carotenoids, Genistein, Isoflavones, Lycopene

Diseases : Prostate Cancer

Pharmacological Actions : Antineoplastic Agents

[+]

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

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Pubmed Data : Int J Oncol. 2015 Apr ;46(4):1629-36. Epub 2015 Jan 27. PMID: 25625225

Article Published Date : Mar 31, 2015

Study Type : Human Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Fibrosarcoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Gene Expression Regulation, Natural Substance Synergy

[+]

Pycnogenol may alleviate adverse effects in oncologic treatment, e.g. deep vein thrombosis.Jan 01, 2008

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Pubmed Data : Mol Vis. 2008;14:1288-92. Epub 2008 Jul 10. PMID: 18927527

Pubmed Data : Biochem Biophys Res Commun. 2004 Mar 12 ;315(3):589-94. PMID: 14975741

Article Published Date : Mar 12, 2004

Study Type : Human In Vitro

Additional Links

Diseases : Glioma

Pharmacological Actions : Antineoplastic Agents, Apoptotic

[+]

Amurensin G had significant antiangiogenic and antitumor growth effects in tamoxifen resistant breast cancer.Sep 30, 2012

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Pubmed Data : Food Chem Toxicol. 2012 Oct ;50(10):3625-34. Epub 2012 Jul 27. PMID: 22842120

Article Published Date : Sep 30, 2012

Study Type : Human In Vitro

Additional Links

Substances : Amurensin G

Diseases : Breast Cancer, Breast Cancer: Drug Resistant

Pharmacological Actions : Anti-Angiogenic, Anti-Tumor, Antineoplastic Agents, Hypoxia-inducible factor-1 (HIF-1) inhibitor, Vascular Endothelial Growth Factor A Inhibitor

Additional Keywords : Epigenetic Modification In Cancer, Gene Expression Regulation

[+]

An extract of Amla fruit inhibited human papillomavirus viral oncogenes responsible for development and progression of cervical cancer.Dec 31, 2012

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Pubmed Data : Nutr Cancer. 2013 ;65 Suppl 1:88-97. PMID: 23682787

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Antineoplaston A2 has anticancer effects. Jan 01, 1987

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Pubmed Data : Drugs Exp Clin Res. 1987 ;13 Suppl 1:1-11. PMID: 3569010

Article Published Date : Jan 01, 1987

Study Type : Human: Case Report

Additional Links

Substances : Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine)

Diseases : Bladder Cancer, Breast Cancer, Esophageal Cancer, Liver Cancer: Metastatic, Lung Cancer, Mesothelioma

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents

[+]

Baicalein enhances cisplatin sensitivity in cervical cancer cells by promoting cuproptosis through the Akt pathway.Sep 30, 2024

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"Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice."Sep 01, 2011

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Pubmed Data : Oncol Rep. 2011 Sep ;26(3):603-8. Epub 2011 May 20. PMID: 21617865

Article Published Date : Sep 01, 2011

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Breast Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

[+]

A combination of cucurbitacin B and gemcitabine had profound anti-proliferative effects in vivo against pancreatic cancer cells.May 31, 2010

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Pubmed Data : Br J Pharmacol. 2010 Jun ;160(4):998-1007. PMID: 20590594

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Pubmed Data : J Clin Invest. 2003 Jan ;111(1):43-50. PMID: 12511587

Anthocyanin enriched sweet potatoes may protect against colorectal cancer by inducing cell-cycle arrest, antiproliferative, and apoptotic mechanisms.Oct 31, 2013

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Pubmed Data : Mol Nutr Food Res. 2013 Nov ;57(11):1908-17. Epub 2013 Jun 19. PMID: 23784800

Article Published Date : Oct 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins, Fiber, Sweet Potato: Purple

Diseases : Colorectal Cancer, Colorectal Cancer: Prevention

Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Plant Extracts, Risk Reduction

[+]

Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α.Sep 14, 2012

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Pubmed Data : Cancer Chemother Pharmacol. 2010 Apr;65(5):895-902. Epub 2009 Aug 19. PMID: 19690861

Article Published Date : Apr 01, 2010

Study Type : Animal Study

Additional Links

Substances : Artemisinin

Diseases : Pancreatic Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic

Additional Keywords : Drug: Gemcitabine, Selective Cytotoxicity, Superiority of Natural Substances versus Drugs

[+]

Benzyl isothiocyanate inhibits prostate cancer development.Jan 21, 2016

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Pubmed Data : Int J Mol Sci. 2016 02 22 ;17(2):264. Epub 2016 Feb 22. PMID: 26907265

Article Published Date : Jan 21, 2016

Study Type : Animal Study

Additional Links

Substances : Benzyl isothiocyanate

Diseases : Prostate Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest, Chemopreventive

Additional Keywords : Isothiocyanates

[+]

Berbamine showed dose-dependent cell growth inhibition effects against A549 cells.Dec 31, 2013

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Pubmed Data : Planta Med. 2014 Apr ;80(6):452-7. Epub 2014 Mar 31. PMID: 24687742

Article Published Date : Mar 31, 2014

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Drug: Carboplatin, Natural Substance/Drug Synergy, Plant Extracts

[+]

Combining green tea polyphenols and quercetin significantly enhanced the antiproliferative and proapoptotic effect in vivo. Dec 31, 2013

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Pubmed Data : J Nutr. 2009 Jul;139(7):1339-46. Epub 2009 Jun 3. PMID: 19326074

Article Published Date : Jul 01, 2009

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin

Diseases : Burkitt Lymphoma

Pharmacological Actions : Antineoplastic Agents, Apoptotic

[+]

Curcumin inhibited growth of murine malignant pleural mesothelioma cell-derived tumors in vivo in part by stimulating apoptosis.Oct 31, 2011

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Pubmed Data : Mol Cell Biochem. 2011 Nov ;357(1-2):83-94. Epub 2011 May 19. PMID: 21594647

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Pubmed Data : Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID: 16243823

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Pubmed Data : PLoS One. 2013 ;8(1):e54736. Epub 2013 Jan 23. PMID: 23372762

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Deguelin

Diseases : Head and Neck Cancer, Squamous cell carcinoma

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil

[+]

Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects.Dec 31, 2016

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Pubmed Data : BMC Complement Med Ther. 2021 Apr 29 ;21(1):133. Epub 2021 Apr 29. PMID: 33926427

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Pubmed Data : Chem Biol Interact. 2014 Dec 5 ;224:149-56. Epub 2014 Nov 4. PMID: 25450235

Article Published Date : Dec 04, 2014

Study Type : Animal Study, In Vitro Study

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Substances : Flavonoids

Diseases : Squamous cell carcinoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cell cycle arrest

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Ganoderma lucidum inhibits tumorigenesis and metastasis of human hepatoma cells in cells and animal models.Jun 10, 2009

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Pubmed Data : J Agric Food Chem. 2009 Jun 10 ;57(11):5049-57. PMID: 19422227

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Pubmed Data : Pharmacol Res. 2009 Nov ;60(5):382-91. Epub 2009 Jul 30. PMID: 19647078

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Pubmed Data : Nutr Cancer. 2000 ;36(2):224-9. PMID: 10890034

Article Published Date : Dec 31, 1999

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Pubmed Data : BMC Complement Altern Med. 2016 Aug 8 ;16:277. Epub 2016 Aug 8. PMID: 27502492

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Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest.Aug 14, 2018

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Pubmed Data : Food Funct. 2018 Aug 15 ;9(8):4500-4507. PMID: 30083664

Article Published Date : Aug 14, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Licorice

Diseases : Glioma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest

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Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity.Jun 30, 2008

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Pubmed Data : Basic Clin Pharmacol Toxicol. 2008 Jul ;103(1):48-54. Epub 2008 Jul 1. PMID: 18484961

Article Published Date : Jun 30, 2008

Study Type : Animal Study

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Substances : Licorice

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Colon Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antineoplastic Agents, Antioxidants, Antiproliferative , Chemoprotective Agents

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Licorice polysaccharide especially of low molecular weight exhibit anticancer and immunomodulatory activities.Dec 14, 2017

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Pubmed Data : BMC Complement Altern Med. 2017 Dec 15 ;17(1):536. Epub 2017 Dec 15. PMID: 29246138

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Pubmed Data : Hum Exp Toxicol. 2014 Nov ;33(11):1176-85. Epub 2014 Feb 14. PMID: 24532706

Article Published Date : Oct 31, 2014

Study Type : Animal Study

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Substances : Luteolin

Diseases : Colon Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Chemotherapeutic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Luteolin could restore sensitivity of oxaliplatin resistant cell lines to chemotherapeutic drugs.Dec 31, 2013

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Pubmed Data : Asian Pac J Cancer Prev. 2014 ;15(6):2911-6. PMID: 24761924

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Luteolin

Diseases : Cancers: Drug Resistant, Colorectal Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Drug: Oxaliplatin, Natural Substance/Drug Synergy

[+]

Luteolin may be a potential candidate for NSCLC therapy, especially for treatment of patients with acquired erlotinib-resistant NSCLC.May 31, 2014

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Pubmed Data : Br J Pharmacol. 2014 Jun ;171(11):2842-53. PMID: 24471765

Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways.Dec 31, 2011

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Pubmed Data : J Exp Clin Cancer Res. 2015 Nov 4 ;34:137. Epub 2015 Nov 4. PMID: 26538209

Article Published Date : Nov 03, 2015

Study Type : Animal Study, In Vitro Study

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Substances : Flavonoids, Mulberry

Diseases : Breast Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest

[+]

Mung bean sprout nuclease exhibits anti-tumor properties.Jan 01, 2006

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Pubmed Data : Neoplasma. 2006;53(5):402-9. PMID: 17013534

Article Published Date : Jan 01, 2006

Study Type : Animal Study

Additional Links

Substances : Mung Bean, Sprouts

Diseases : Tumors

Pharmacological Actions : Anti-Tumor, Antineoplastic Agents, Antiproliferative

[+]

NAC and myo-inositol work synergistically to prevent lung tumor formation in a mouse model. Sep 01, 2002

Pubmed Data : Drugs Exp Clin Res. 1987 ;13 Suppl 1:45-50. PMID: 3569015

Article Published Date : Jan 01, 1987

Study Type : Animal Study

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Pharmacological Actions : Antineoplastic Agents

[+]

Pharmacokinetic study of radioactive antineoplaston A10 in rats and mice.Jan 01, 1990

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Pubmed Data : Drugs Exp Clin Res. 1990 ;16(7):351-5. PMID: 2092961

Article Published Date : Jan 01, 1990

Study Type : Animal Study

Additional Links

Pharmacological Actions : Antineoplastic Agents

[+]

Pharmacological effects of natural components against ovarian cancer and mechanisms.Dec 31, 2020

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Pubmed Data : Adv Exp Med Biol. 2021 ;1330:55-73. PMID: 34339030

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Ellagic Acid, Lignans, Luteolin, Mangiferin

Diseases : Ovarian Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Phellinus linteus has a synergistic effect with the drug doxorubicin in prostate cancer. Aug 07, 2006

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Pubmed Data : Br J Cancer. 2006 Aug 7;95(3):282-8. Epub 2006 Jul 25. PMID: 16868541

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Pubmed Data : FEBS J. 2015 Mar ;282(6):1111-25. Epub 2015 Feb 11. PMID: 25611565

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Pubmed Data : Front Oncol. 2019 ;9:352. Epub 2019 May 9. PMID: 31143704

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Pubmed Data : J Nutr. 1999 Sep;129(9):1628-35. PMID: 10460196

Article Published Date : Sep 01, 1999

Study Type : Animal Study

Additional Links

Substances : Daidzein, Genistein, Soy Protein

Diseases : Prostate Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antineoplastic Agents, Apoptotic, Cell cycle arrest

[+]

Structure identification of Ganoderma lucidum spore polysaccharides and their antitumor activity in vivo.May 15, 2024

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Pubmed Data : Molecules. 2024 May 16 ;29(10). Epub 2024 May 16. PMID: 38792209

Article Published Date : May 15, 2024

Study Type : Animal Study

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Substances : Reishi Mushroom

Diseases : Colon Cancer, Liver Cancer, Lung Cancer

Pharmacological Actions : Antineoplastic Agents

Additional Keywords : Polysaccharides

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View the Evidence: 1468 Abstracts with Antineoplastic Agents Research

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Acupressure has therapeutic value for chemotherapy-induced nausea and vomiting.Jul 01, 2007

Calcium and magnesium can lessen the incidence of oxaliplatin induced neuropathy.May 31, 2013

Efficacy of biological response modifier lentinan with chemotherapy for advanced cancer: a meta-analysis.Sep 30, 2017

There is evidence to support the use of topical calendula for prophylaxis of acute dermatitis during radiotherapy and Traumeel S mouthwash in the treatment of chemotherapy-induced stomatitis. Jan 01, 2009

There is no firm evidence to support or refute transarterial (chemo)embolisation for unresectable hepatocellular carcinoma. for patients with unresectable HCC.Jan 01, 2011

Finger acupressure may decrease nausea among women undergoing chemotherapy for breast cancer.Jan 01, 2000

A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies.Dec 31, 2017

A proprietary honey-based herbal formula reduces chemotherapy-induced neutropenia and the need for colony-stimulating factors.Jan 01, 2006

Adjuvant ginger supplementation is associated with better chemotherapy-induced nausea-related quality of life and less cancer-related fatigue.Aug 11, 2017

An omega-3 fatty acid rich diet reduces toxicity of chemoradiation therapy for patients with esophageal cancer.Mar 01, 2008

Antineoplasto exhibits antitumor activity against malignant brain tumors.Jan 01, 1995

Antineoplaston A10 and AS2-1 in children with recurrent and progressive multicentric glioma compares favorably to radiation therapy and chemotherapy.Jan 01, 2004

Antineoplaston A10 and AS2-1 treatment is effective and relatively safe for the long-term survival of high-risk pediatric patients with primitive neuroectodermal tumors.Jun 01, 2005

Antineoplaston AS2-1 prolongs the recurrence-free interval between regional treatments and improves survival rate of these patients.Mar 01, 2003

Beta-cryptoxanthin synergistically enhances the antitumoral activity of oxaliplatin.Sep 30, 2015

Caffeine potentiates chemotherapy for metastatic osteosarcoma.Sep 01, 2009

Children treated for solid tumors or lymphoma with chemotherapy have increased caries of the primary teeth.Jan 01, 2010

Combination chemotherapy and chemoradiation does not improve overall survival in inoperabe advanced pancreatic cancer over single chemotherapy alone.Jan 01, 2009

Curcumin selectively induces programmed cell death in cutaneous T-cell lymphoma cell lines and in peripheral blood mononuclear cells (PBMCs).Aug 01, 2010

Dosage Study: A daily dose of 3.6 g of curcumin engendered 62% and 57% decreases in inducible PGE(2) production in blood samples taken 1 hour after dose on days 1 and 29, respectively, in patients with advanced colorectal cancer.Oct 15, 2004

Dosage Study: Turmeric extract can be administered safely to patients at doses of up to 2.2 g daily, equivalent to 180 mg of curcumin.Jul 01, 2001

Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea.Jun 30, 2012

Hyperbaric oxygen therapy may be an appropriate therapeutic regimen for the treatment of patients with osteosarcoma.Nov 01, 2009

Integrated Chinese-western therapy was superior to western therapy alone with significant survival differences. Jul 31, 2013

Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma. Jul 01, 2008

Lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer.Jul 01, 2009

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

Pycnogenol may alleviate adverse effects in oncologic treatment, e.g. deep vein thrombosis.Jan 01, 2008

Safety & Dosage Review: Curcumin. Jan 01, 2006

Safety of high-dose intravenous mistletoe therapy in pediatric cancer patients: A case series.Sep 30, 2018

Solasodine glycoside cream is a safe therapy for basal cell carcinoma, with a cure rate of 66% at 8 weeks and 78% at 1 year follow-up.Jan 01, 2008

Soy isoflavones may benefit some patients with prostate cancer. Jan 01, 2003

The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas in patients with Familialadenomatous polyposis without appreciable toxicity. Aug 01, 2006

The decrease in neutrophil count caused by breast carcinoma chemotherapy was ameliorated by dietary supplementation with a multivitamin or vitamin E.Sep 01, 2004

White button mushroom appears to both impact PSA levels and modulate the biology of biochemically recurrent prostate cancer.Aug 31, 2015

1,3,4-tri-O-galloyl-6-O-caffeoyl-β-D-glucopyranose, a New Anti-Proliferative Ellagitannin, Regulates the Expression of microRNAs in HepG(2) Cancer Cells.Oct 01, 2011

Alpha-bisobolol strongly induces apoptosis in glioma cells.Mar 12, 2004

Amurensin G had significant antiangiogenic and antitumor growth effects in tamoxifen resistant breast cancer.Sep 30, 2012

An extract of Amla fruit inhibited human papillomavirus viral oncogenes responsible for development and progression of cervical cancer.Dec 31, 2012

Anti-cancer activity of bromelain nanoparticles by oral administration.Nov 30, 2014

Anti-tumor and immunoregulatory effects of fermented papaya preparation.Dec 31, 2015

Berberine can significantly inhibit the activity of N-acetyltransferase in human lung cancer cell line A549.May 31, 2014

Berberine induced apoptosis and DNA damage in human osteosarcoma lines that were treated.Sep 30, 2014

Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.Nov 14, 2012

Capsaicin inhibits 5-FU-induced autophagy and rendering Cholangiocarcinoma cells more susceptible to 5-FU-induced apoptosis.Dec 31, 2014

Effects of thymoquinone and the curcumin analog EF-24 on the activity of the enzyme paraoxonase-1 in human glioblastoma cells U87MG.Nov 30, 2024

Fucoxanthin activates apoptosis and suppresses invasion and migration glioblastoma cells.Sep 30, 2016

Ganoderic acids suppress growth and invasive behavior of breast cancer cells.Apr 30, 2008

Magnetic fields may upregulate chemoresistance in human glioblastoma.Jan 01, 2018

Nigella sativa has successfully produced inhibition of growth of MCF cell lines with an equivalent potency as that of the standard cisplatin.Mar 31, 2015

Promising cytotoxic activity profile of fermented wheat germ extract in human cancer cell lines.Apr 15, 2011

The annatto constituent cis-bixin has intriguing selective anti-myeloma activity.Sep 30, 2010

The synergistic antiproliferative action of combined γ-tocotrienol and sesamin treatment in mouse and human mammary cancer cells was cytostatic, not cytotoxic.Dec 31, 2012

These results indicate that all analyzed cell lines including are highly sensitive to the cytotoxic, pro-oxidant effects of high doses of sodium ascorbate.Oct 31, 2015

This paper describes a tocotrienol nano emulsion with enhanced effectiveness against skin carcinomas.Jun 01, 2016

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.Nov 01, 2018

Thymoquinone could be useful as a potential chemotherapeutic agent in the management for brain tumours.Aug 11, 2010

"Antineoplaston A in cancer therapy. (I)."Jan 01, 1977

"Phase I clinical studies of antineoplaston A3 injections."Jan 01, 1987

"Phase I clinical studies of antineoplaston A5 injections."Jan 01, 1987

a patient suffering from HCC with lung metastasis demonstrated regression of metastatic disease while consuming guyabano fruit extract in the absence of conventional chemotherapy. Feb 08, 2015

Acacetin inhibits in vitro and in vivo angiogenesis and downregulates Stat signaling and VEGF expression.Sep 30, 2013

Anti-cervical cancer activity of secondary metabolites of endophytic fungi from Ginkgo biloba.Dec 31, 2019

Anti-tumor activity of arjunolic acid against ehrlich ascites carcinoma cells.Jul 31, 2016

Anticancer investigation of fullerene C60 on DMBA induced breast cancer.Feb 14, 2022

Antineoplaston A10 and AS2-1 has an inhibitory effect on human hepatocellular carcinoma.Jan 01, 1996

Antineoplaston A2 has anticancer effects. Jan 01, 1987

Baicalein enhances cisplatin sensitivity in cervical cancer cells by promoting cuproptosis through the Akt pathway.Sep 30, 2024

Cucumber-derived nanovesicles containing cucurbitacin B for non-small cell lung cancer therapy.Dec 31, 2021

Curcumin analog WZ26 induces ROS and cell death.Dec 30, 2023

Curcumin has been used to successfully treat infantile hemangioendothelioma of the liver.Aug 01, 2010

Escin induces apoptosis in human bladder cancer cells.Dec 04, 2018

Antineoplastic Agents

View the Evidence:
1468 Abstracts with Antineoplastic Agents Research