Antiproliferative

Name	AC	CK
Curcumin	475	663
Flavonoids	266	310
Ginsenosides	206	279
Resveratrol	168	212
Berberine	131	182
EGCG (Epigallocatechin gallate)	105	166
Sulforaphane	96	155
Polyphenols	94	132
Quercetin	109	122
Thymoquinone	97	121
Apigenin	77	109
Tanshinone IIA	93	108
Vitamin C	76	108
Shikonin	73	103
Licorice	79	96
Vitamin D	51	92
Fucoidan	61	91
Melatonin	58	89
Cucurbitacin B	63	86
Green Tea	39	83
Genistein	62	77
Anthocyanins	45	75
Luteolin	64	75
Cannabidiol	48	73
Cannabinoids	51	72
Lycopene	32	72
Ursolic Acid	57	70
Oridonin	53	68
Pterostilbene	53	68
Reishi Mushroom	53	68
Honokiol	54	67
Salvia miltiorrhiza	61	66
Xanthohumol	54	66
Beta-Elemene	57	64
Ginkgo biloba	45	64
Naringenin	43	64
Silibinin	45	63
Gallic Acid	50	62
Catechin	36	58
Piperine	33	56
Indole-3-Carbinol	41	55
Fisetin	44	54
Isoliquiritigenin	41	54
Cordyceps Militaris	42	53
Betulinic acid	46	52
Lactoferrin	43	52
Piperlongumine	39	51
Ellagic Acid	38	50
Emodin	44	50
Parthenolide	36	48
Wogonin	35	48
Garlic	39	46
Grape Seed Extract	28	45
Water: Deuterium Depleted	15	45
Curcumol	37	44
Paeoniflorin	37	44
Baicalein	35	43
Formononetin	33	43
Ashwagandha	32	42
Myricetin	36	42
Chrysin	34	41
Crocin	28	41
Astragaloside	31	40
Flaxseed	14	40
Isoflavones	30	40
Medicinal Mushrooms	18	40
Gingerol	30	39
Mulberry	30	39
Nobiletin	33	39
Organosulfur Compounds	31	38
Moringa oleifera	29	37
Astaxanthin	29	36
Caffeic acid phenethyl ester	28	36
Celastrol	29	36
Chaga Mushroom (Inonotus obliquus)	25	36
Deguelin	33	36
Kaempferol	32	36
Maitake Mushroom	12	36
Dandelion	27	35
Ginger	29	35
NAC (N-acetyl-L-cysteine)	18	35
Fermented Foods and Beverages	23	34
Isothiocyanates	29	34
Sinomenine	28	34
Elecampane	32	33
Paeonol	26	33
Artesunate	29	32
Diosgenin	30	32
Huaier (Trametes robiniophila murr)	26	32
Lotus	29	32
Turmeric	25	32
Andrographolide	26	31
Artemisinin	20	31
Nigella sativa (aka Black Seed)	20	31
Puerarin	25	31
Vitamin E	21	31
Arctigenin	21	30
Bee Venom	25	30
Berbamine	23	30
Phenethyl isothiocyanate	24	30
Pomegranate	27	30
Delta-tetrahydrocannabinol (THC)	19	29
Phloretin	22	29
Fucoxanthin	21	28
Peony	23	28
Magnolol	22	27
6-Shogaol	21	26
Cannabis	19	26
Lignans	12	26
Blueberry	20	25
Cucurbitacin E	21	25
Frankincense	17	25
Hesperidin	17	25
Horse Chestnut	19	25
Piceatannol	20	25
Zerumbone	21	25
Allicin	22	24
Andrographis	19	24
Asiatic Acid	20	24
Carnosic Acid	21	24
Aloe Vera	19	23
Black Tea	19	23
Bufalin	22	23
Mangosteen	16	23
Oleuropein	21	23
Seaweed: Brown	16	23
Selenium	16	23
Sesamin	15	23
Bee Propolis	21	22
Mangiferin	18	22
Rosemary	15	22
Spirulina	13	22
Stilbenes	20	22
Urolithin A	16	22
Bisdemethoxycurcumin	12	21
Caffeic Acid	10	21
Citrus naringin	18	21
Demethoxycurcumin	13	21
Fiber	8	21
Lichens	21	21
Neem	19	21
Carvacrol	18	20
Cruciferous Vegetables	11	20
Grape	17	20
Icariin	16	20
Prunella vulgaris	14	20
Rhubarb	11	20
Cinnamon	15	19
Fish Oil	7	19
Ginseng	14	19
Ginseng (Korean)	13	19
Omega-3 Fatty Acids	13	19
Safflower	14	19
Tocotrienol: Gamma	10	19
Xanthones	17	19
Amygdalin	13	18
Angelica	6	18
Benzyl isothiocyanate	15	18
Biochanin A	14	18
Cannabinoids: Synthetic	12	18
Carotenoids	14	18
Diosmin	12	18
Gold (nanoparticles)	16	18
Graviola	11	18
Panax Notoginseng	14	18
Phellinus Linteus	15	18
Raspberry	15	18
Rutin	14	18
Adlay	16	17
DHA (Docosahexaenoic Acid)	13	17
Mistletoe	14	17
Patchouli	13	17
Saffron	14	17
Verbascoside	15	17
Chlorella (Algae)	12	16
Lithospermum erythrorhizon	6	16
Lupeol	14	16
Olive leaf extract	12	16
Probiotics	12	16
Tangeretin	15	16
Vitamin K2	7	16
Walnut	14	16
Camel Milk	7	15
Chlorogenic Acid	13	15
Chokeberry	11	15
Enterolactone	4	15
Mushrooms: All	12	15
Nordihydroguaiaretic acid (NDGA)	12	15
Rose	14	15
Rosmarinic acid	11	15
Strawberry	5	15
Tannic Acid	11	15
Tetrahydrocurcumin	9	15
Burdock	13	14
Delphinidin	13	14
Echinacea	11	14
Harmine	13	14
Iodine	4	14
Nettle	11	14
Psychedelics:All	12	14
Punicalagin	14	14
Bitter Orange	4	13
Black Pepper	9	13
Bromelain	10	13
Carnosol	11	13
Carrot	8	13
Eriodictyol	11	13
Eugenol	13	13
Garlic: Aged	7	13
Goji	13	13
Poria cocos	11	13
Proanthocyanidins	11	13
Silymarin	10	13
Soy Protein	7	13
Tomato	8	13
Toona sinensis	6	13
acetyl-11-keto-beta-boswellic acid	10	13
Bael	7	12
Bitter Melon	12	12
Caffeine	3	12
Capsaicin	10	12
Cinnamaldehyde	9	12
Cryptoxanthin	3	12
Cucurbitacin D	11	12
Dogwood	6	12
Fig	10	12
Homeopathic Medicine: All	10	12
Leonurine	7	12
Motherwort	2	12
Noni	11	12
Oleanolic acid	10	12
Rosemaric Acid	10	12
Silver (nanoparticles)	10	12
Soursop	10	12
Syrian rue	10	12
Vanillic Acid	5	12
Vitamin E: Gamma-Tocopherol	5	12
Wheat Grass	9	12
Amla Fruit	4	11
Amygdalin (laetrile)	2	11
Anandamide	6	11
Avocado	7	11
Bai Zhu	9	11
Cordyceps sinensis	8	11
Crocetin	10	11
Curcuminoids	7	11
Daidzein	9	11
Gynostemma	9	11
Lactobacillus casei	7	11
Lysine	5	11
Nexrutine (Phellodendrom)	6	11
Phlorotannins	10	11
Pycnogenol (Pine Bark)	2	11
Sage	8	11
Syringic Acid	8	11
Theaflavins	9	11
Thistle	9	11
Wheat Germ	7	11
Whey	8	11
Antrodia camphorata	5	10
Apple Polyphenols	6	10
Apples	8	10
Babchi	9	10
Beta Sitosterol	8	10
Carbon 60	5	10
Citrus Peel	9	10
Cranberry	9	10
Cyanidin 3-glucoside	7	10
Olive	9	10
Progesterone	1	10
Red Sage	9	10
Royal Jelly	8	10
Saikosaponin	10	10
Shallot	9	10
Thymol	8	10
Tocotrienol: Delta	8	10
Vitamin A	8	10
Alpha-Lipoic Acid	8	9
Apple	8	9
Arugula	4	9
Cardamonin	9	9
Dates	8	9
Diosmetin	9	9
Fenugreek	9	9
Garcinia indica	4	9
Genipin	6	9
Hawthorn	5	9
Hydroxytyrosol	9	9
Isothiocyanate	5	9
MSM (Methylsulfonylmethane)	7	9
Manuka Honey	4	9
Orange	9	9
Panaxadiol	4	9
Persimmon	8	9
Pomegranate Peel	9	9
Prickly Pear Cactus	8	9
Shiitake Mushroom	7	9
Soy	5	9
Vanillin	7	9
Vitamin K	7	9
Wormwood	8	9
Bacopa	8	8
Beans: All	8	8
Beet	8	8
Black Raspberry	4	8
Calcium	4	8
Cannabigerol	5	8
Eucalyptus	7	8
Ferulic acid	8	8
Jujube	6	8
Kiwifruit	8	8
Lactobacillus plantarum	6	8
Milk Thistle	6	8
Mululuza	6	8
Orange: Mandarin	3	8
Papaya	7	8
Perilla	7	8
Pine Needle	7	8
Piperidines	7	8
Seaweed	7	8
Sesamol	6	8
Sprouts	7	8
Thyme	7	8
Vitexins	7	8
phytoestrogens	5	8
18β-Glycyrrhetinic Acid	5	7
Agrimony	5	7
Astragalus	6	7
Banana	5	7
Bergamot	7	7
Bilberry	4	7
Catechols	6	7
Chinese Skullcap	5	7
Damnacanthal	7	7
Evodiamine	6	7
Folate	6	7
Geraniol	7	7
Guava	6	7
Honey	6	7
Honeysuckle	6	7
Horsetail	3	7
Jambul	5	7
Kahweol	7	7
Mango	5	7
Myrrh	5	7
Oregano	6	7
Plantago	6	7
Pumpkin	3	7
Spinach	4	7
Sweet Potato: Purple	5	7
Vitamin E: Gamma-tocotrienol	7	7
Vitamin E: delta-tocopherol	5	7
Apple Pectin	3	6
Asparagus	5	6
Bergamot orange	5	6
Black Cohosh	6	6
Blackberry	5	6
Bloodroot	2	6
Butyrate	5	6
Cafestol	4	6
Carnosine	6	6
Corn Silk	6	6
Daisy	5	6
Endocannabinoids	5	6
Gac	4	6
Galbanic Acid	6	6
Ginseng (Siberian)	5	6
Glycyrrhizin	5	6
Krill	4	6
Lactobacillus probiotics	2	6
Lemon	4	6
Lemongrass	5	6
Limonoids	2	6
Litchi	6	6
Mustard: Field/Turnip	2	6
Olive Oil	5	6
Onion	6	6
Oyster Mushroom	6	6
P-Coumaric Acid	6	6
Panax Ginseng	4	6
Parsley	6	6
Pine Bark Extract	6	6
Proline	4	6
Red Clover	5	6
Rice Bran	6	6
Safranal	5	6
Sea buckthorn	6	6
St. Johns Wort	6	6
Sweet Potato	4	6
Tribulus Terrestris	3	6
beta-Carotene	5	6
Arginine	3	5
Barberry	5	5
Betel	4	5
Bifidobacterium Infantis	1	5
Broccoli	5	5
Broccoli Sprouts	3	5
Chrysanthemum Indicum	5	5
Coffee	5	5
Curcumin: Degradiation byproducts	1	5
D-Limonene	5	5
Dong Quai	1	5
Enterodiol	3	5
False Black Pepper	5	5
Geranium	3	5
Ginseng (American)	5	5
Gotu Kola	4	5
Hemp Seed	5	5
Hops	5	5
Hydrogen Water	3	5
Hyperforin	3	5
Indigo naturalis	5	5
Inositol Hexaphosphate	4	5
Kava Kava	3	5
Kefir	4	5
Lactobacillus Acidophilus	5	5
Lactobacillus paracasei	5	5
Lactobacillus rhamnosus	4	5
Lactobacillus salivarius	2	5
Lemon Balm	4	5
Ligustrazine	5	5
Loquat	4	5
Lychee	5	5
Magnolia	4	5
Modified Arabinoxylan Rice Bran (MGN-3)	3	5
Myo-inositol	3	5
Oleocanthal	5	5
Orthosiphon	4	5
Pea	4	5
Peanut	4	5
Propolis: Brazillian	5	5
Red Yeast Rice	3	5
Rooibos	5	5
S-Adenosylmethionine (SAMe)	4	5
Scopoletin	5	5
Sea Cucumber	3	5
Sesame Seeds	4	5
Sophora Flavescens	4	5
Stigmasterol	4	5
Theanine	3	5
Tomatidine	2	5
Turkey Tail Mushroom	1	5
Turmerones	4	5
Valerian	3	5
White Tea	4	5
Zataria multiflora	3	5
Acorus calamus	3	4
Agaricus Blazei	3	4
Berries: All	4	4
Beta-Caryophyllene	4	4
Black Bean	4	4
Celery	3	4
Clove	4	4
Cocoa	4	4
Coumestrol	4	4
Curcuma phaeocaulis	3	4
Curry Leaves	3	4
EPA (Eicosapentaenoic Acid)	3	4
Essential Oils: Unspecified	3	4
Flaxseed Oil	2	4
Glycyrrhiza uralensis	3	4
Grapefruit	4	4
Guduchi	4	4
Hibiscus sabdariffa	4	4
Holy Basil	3	4
Hydrogen Peroxide	4	4
Hydrogen: Molecular	2	4
Indian Gooseberry	4	4
Isoquercitrin	2	4
Lactobacillus rhamnosus GG	4	4
Lettuce	3	4
Lion's Mane (Hericium Erinaceus)	4	4
Lutein	3	4
Nisin	3	4
Palash	3	4
Peach	4	4
Pectin	3	4
Phyllanthus urinaria	4	4
Plum	4	4
Propolis: Bee	4	4
Pumpkin Seeds	4	4
Purslane	4	4
Radish	4	4
Shemamruthaa	2	4
Solanum nigrum (black nightshade)	2	4
Stearic Acid (stearate)	2	4
Tea	3	4
Terminalia	4	4
Tongkat Ali	4	4
Trichosanthes Kirilowii	3	4
Tualang Honey	3	4
Viruses: Beneficial	2	4
Yerba Santa	2	4
Zinc	4	4
Zyflamend	4	4
cottonseed oil (gossypol)	3	4
Acai	2	3
Alpha Linolenic Acid	2	3
Bamboo	2	3
Barley	2	3

[+]

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Transl Cancer Res. 2021 Dec ;10(12):5390-5405. PMID: 35116386

Article Published Date : Nov 30, 2021

Study Type : Meta Analysis, Review

Additional Links

Substances : Fucoidan

Diseases : Cancers: All

Pharmacological Actions : Anti-metastatic, Antiproliferative

[+]

Berberine exerted anti-tumor effects in a variety of tumors in vivo.Jun 16, 2019

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Pubmed Data : J Nutrigenet Nutrigenomics. 2017 Oct 18 ;10(3-4):126-135. Epub 2017 Oct 18. PMID: 29040973

Article Published Date : Oct 17, 2017

Study Type : Meta Analysis, Review

Additional Links

Substances : EGCG (Epigallocatechin gallate), Sulforaphane

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Epigenetic Modification In Cancer

[+]

Cancer stem cells as a prognostic biomarker and therapeutic target using curcumin/ piperine extract for multiple myeloma.Sep 30, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Ethnopharmacol. 2009 Mar 18;122(2):234-9. PMID: 19330917

Evidence of an inhibitory effect of diet and exercise on prostate cancer cell growth.Aug 31, 2001

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Pubmed Data : J Urol. 2001 Sep ;166(3):1185-9. PMID: 11490320

Article Published Date : Aug 31, 2001

Study Type : Human Study

Additional Links

Substances : Fiber

Diseases : Prostate Cancer

Therapeutic Actions : Ai-Chi Aquatic Exercise , Dietary Modification: Low Fat Diet

Pharmacological Actions : Antiproliferative

[+]

Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.Mar 31, 2013

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Pubmed Data : PLoS One. 2012 ;7(2):e30951. Epub 2012 Feb 7. PMID: 22347413

Article Published Date : Jan 01, 2012

Study Type : Human Study

Additional Links

Substances : Green Tea, Polyphenols

Diseases : Lung Cancer: Prevention

Pharmacological Actions : Antiproliferative , Chemopreventive

Additional Keywords : Risk Reduction

Problem Substances : Tobacco: Smoking

[+]

High dose parenteral ascorbate inhibited pancreatic cancer growth and metastasis.Jan 06, 2017

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Pubmed Data : Int J Oncol. 2015 Apr ;46(4):1629-36. Epub 2015 Jan 27. PMID: 25625225

Article Published Date : Mar 31, 2015

Study Type : Human Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Fibrosarcoma

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Gene Expression Regulation, Natural Substance Synergy

[+]

Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption.Feb 16, 2015

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Pubmed Data : Clin Cancer Res. 2015 Feb 17. Epub 2015 Feb 17. PMID: 25691730

Pubmed Data : Zhong Xi Yi Jie He Za Zhi. 1991 Oct ;11(10):598-9, 580. PMID: 1806305

Article Published Date : Sep 30, 1991

Study Type : Human Study

Additional Links

Substances : Lithospermum erythrorhizon, Shikonin

Diseases : Lung Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Immunomodulatory

[+]

Sinecatechins 10% ointment presents a botanically based alternative to currently available treatments for EGWs that offers a satisfactory balance of clearance rates, reduced frequency of lesion recurrence.Dec 31, 2014

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Pubmed Data : Skin Therapy Lett. 2015 Jan-Feb;20(1):6-8. PMID: 25807215

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Catechin , Green Tea

Diseases : Genital Warts, Human Papilloma Virus

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Antiviral Agents

Additional Keywords : Natural Substances Versus Drugs

[+]

Supplementation with fish oil for the first 9 weeks of chemotherapy may contribute to delay in tumor progression in colorectal patients.Dec 22, 2015

Pubmed Data : Oncol Rep. 2017 Feb 14. Epub 2017 Feb 14. PMID: 28260058

Article Published Date : Feb 13, 2017

Study Type : Human In Vitro

Additional Links

Substances : Apigenin

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic

[+]

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Pubmed Data : Mol Med Rep. 2012 Jan ;5(1):196-201. Epub 2011 Sep 30. PMID: 21964700

Article Published Date : Dec 31, 2011

Study Type : Human In Vitro

Additional Links

Substances : Pumpkin

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

[+]

Curcumin can suppress the proliferation of keratinocytes with IL-22 or without IL-22 treatment. Dec 31, 2014

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Pubmed Data : Int J Clin Exp Med. 2015;8(6):9580-9584. Epub 2015 Jun 15. PMID: 26309628

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Curcumin

Diseases : Psoriasis

Pharmacological Actions : Antiproliferative

[+]

Curcumin inhibited proliferation and induced apoptosis in both KG-1 and U937 cells.Jun 30, 2016

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Pubmed Data : Radiat Res. 2008 Sep ;170(3):327-34. PMID: 18763855

Article Published Date : Sep 01, 2008

Study Type : Human In Vitro

Additional Links

Pharmacological Actions : Antiproliferative , Apoptotic

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Apoptotic

[+]

Electromagnetic field exposure induces caspase 3 activation, a protein involved in apoptosis as well as other cellular processes.Sep 01, 2008

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Pubmed Data : Radiat Res. 2008 Sep ;170(3):327-34. PMID: 18763855

Article Published Date : Sep 01, 2008

Study Type : Human In Vitro

Additional Links

Pharmacological Actions : Antiproliferative , Apoptotic

Anti Therapeutic Actions : Electromagnetic Field Harms, Electromagnetic Radiation

Adverse Pharmacological Actions : Apoptotic

[+]

Electromagnetic fields induce astrocytoma proliferation in vitro.Jan 12, 2009

[+]

Graviola extracts inhibited the proliferation of HL-60 cells in a concentration dependent manner and induced apoptosis.Dec 31, 2013

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Pubmed Data : BMC Complement Altern Med. 2014 ;14(1):516. Epub 2014 Dec 24. PMID: 25539720

Article Published Date : Dec 31, 2013

Study Type : Human In Vitro

Additional Links

Substances : Graviola

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic

[+]

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Pubmed Data : Phytother Res. 2012 May 8. Epub 2012 May 8. PMID: 22566066

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Pubmed Data : PLoS One. 2017 ;12(1):e0169854. Epub 2017 Jan 12. PMID: 28081224

Pubmed Data : J Agric Food Chem. 2016 Sep 14 ;64(36):6826-37. Epub 2016 Sep 2. PMID: 27538679

Article Published Date : Sep 13, 2016

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Apple Polyphenols, Phloretin

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Tumor Suppressor Protein p53 Upregulation

[+]

The present study results indicated that human bladder cancer T-24 cells are highly sensitive to growth inhibition by apigenin.Dec 31, 2014

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Pubmed Data : Cancer Cell Int. 2015 ;15:33. Epub 2015 Mar 29. PMID: 25859163

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Apigenin

Diseases : Bladder Cancer, Bladder Cancer: Prevention

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Dose Response

[+]

The proapoptotic effect of cannabinoids on tumor cells is mediated by a ceramide dependent upregulation of the stress protein p8.Mar 31, 2006

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Pubmed Data : Oncol Lett. 2015 Sep ;10(3):1597-1604. Epub 2015 Jul 10. PMID: 26622717

Article Published Date : Aug 31, 2015

Study Type : Human In Vitro

Additional Links

Substances : Moringa oleifera

Diseases : Liver Cancer, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Plant Extracts

[+]

This study compares Boswellia sacra essential oil hydrodistilled at 100 °C vs 78 °C in inducing cancer cell death in cultured breast cancer cells; the oil prepared at 100 °C was more potent in inducing breast cancer cell-specific cytotoxicity.Dec 31, 2010

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Pubmed Data : Oncol Rep. 2015 Nov ;34(5):2375-84. Epub 2015 Aug 20. PMID: 26323892

Article Published Date : Oct 31, 2015

Study Type : Human In Vitro

Additional Links

Substances : Ursolic Acid

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Cancer Stem Cells

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Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer.Jan 09, 2017

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Pubmed Data : Int J Oncol. 2016 Feb 18. Epub 2016 Feb 18. PMID: 26892433

Article Published Date : Feb 17, 2016

Study Type : Human In Vitro

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Substances : Mangosteen

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation

[+]

γ-tocotrienol and 6-gingerol when used in combination act synergistically increasing cytotoxicity and apoptosis in cancer cells.Dec 31, 2014

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Pubmed Data : Molecules. 2015 ;20(6):10280-97. Epub 2015 Jun 3. PMID: 26046324

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

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Substances : Gingerol , Tocotrienol: Gamma

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive

Additional Keywords : Natural Substance Synergy

[+]

20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo.Apr 30, 2022

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Pubmed Data : Heliyon. 2022 Nov ;8(11):e11183. Epub 2022 Oct 19. PMID: 36345524

Article Published Date : Oct 31, 2022

Study Type : Animal Study, In Vitro Study

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Substances : Prunella vulgaris

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Andrographolide inhibits ER-positive breast cancer.Dec 31, 2021

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Pubmed Data : Biofactors. 2024 May 17. Epub 2024 May 17. PMID: 38760945

Article Published Date : May 16, 2024

Study Type : Animal Study, In Vitro Study

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Substances : Cannabichromene , Cannabidivarin, Cannabigerol , Cannabinoids

Diseases : Multiple Myeloma

Pharmacological Actions : Antiproliferative , Apoptotic

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Baicalein enhances cisplatin sensitivity in cervical cancer cells by promoting cuproptosis through the Akt pathway.Sep 30, 2024

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Pubmed Data : Biomed Pharmacother. 2024 Oct ;179:117415. Epub 2024 Sep 11. PMID: 39265236

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Pubmed Data : Antioxidants (Basel). 2022 Jun 13 ;11(6). Epub 2022 Jun 13. PMID: 35740057

Article Published Date : Jun 12, 2022

Study Type : Animal Study, In Vitro Study

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Substances : Tribulus Terrestris

Diseases : Breast Cancer, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Antiproliferative

[+]

Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1.Dec 12, 2022

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Pubmed Data : Thorac Cancer. 2023 Feb ;14(4):371-380. Epub 2022 Dec 16. PMID: 36525508

Article Published Date : Jan 31, 2023

Study Type : Animal Study, In Vitro Study

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Substances : Beta-Elemene

Diseases : Cancers: Drug Resistant, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Gefitinib

[+]

Formononetin inhibits progression of endometriosis.Jun 29, 2023

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Pubmed Data : Anticancer Agents Med Chem. 2023 ;23(7):832-838. PMID: 36330648

Article Published Date : Dec 31, 2022

Study Type : Animal Study, In Vitro Study

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Substances : Reishi Mushroom

Diseases : Colon Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin

[+]

Ganoderma lucidum enhances carboplatin chemotherapy effect by inhibiting the DNA damage response pathway and stemness.Dec 31, 2021

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Pubmed Data : Am J Cancer Res. 2022 ;12(3):1282-1294. Epub 2022 Mar 15. PMID: 35411244

Hyperforin suppresses oncogenic kinases and induces apoptosis in colorectal cancer cells.Dec 31, 2022

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Pubmed Data : In Vivo. 2023 ;37(1):182-189. PMID: 36593022

Article Published Date : Dec 31, 2022

Study Type : Animal Study, In Vitro Study

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Substances : Hyperforin

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Icariin inhibits the malignant progression of lung cancer.May 31, 2022

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Pubmed Data : Life Sci. 2021 Nov 15 ;285:119961. Epub 2021 Sep 15. PMID: 34536497

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Pubmed Data : Phytomedicine. 2023 Jun ;114:154780. Epub 2023 Mar 21. PMID: 37004402

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Pubmed Data : Chin J Physiol. 2022 ;65(6):319-327. PMID: 36588358

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

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Substances : Leonurine

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

[+]

Licochalcone A induces ferroptosis in hepatocellular carcinoma.Dec 31, 2022

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Pubmed Data : J Orthop Surg Res. 2023 Mar 9 ;18(1):180. Epub 2023 Mar 9. PMID: 36895009

Article Published Date : Mar 08, 2023

Study Type : Animal Study, In Vitro Study

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Substances : Piperine

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Preclinical evidence that arctigenin effectively and selectively targets clear cell renal cell carcinoma.Dec 31, 2022

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Pubmed Data : Nutr Cancer. 2023 ;75(5):1373-1381. Epub 2023 Mar 22. PMID: 36947006

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Pubmed Data : Cell Death Dis. 2022 Apr 19 ;13(4):374. Epub 2022 Apr 19. PMID: 35440077

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Pubmed Data : Arterioscler Thromb Vasc Biol. 2010 Mar ;30(3):426-35. Epub 2010 Jan 7. PMID: 20056909

Article Published Date : Mar 01, 2010

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View the Evidence: 7535 Abstracts with Antiproliferative Research

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The efficacy of curcumin application to melanoma in mice.Jul 31, 2024

A meta-analysis of ginsenoside Rg3 combined with chemotherapy for digestive system cancer in China.Dec 31, 2018

Administration of lycopene appears to inhibit the initiation and progression of cancer in animal models of hepatocellular carcinoma.Dec 31, 2019

Anthocyanin consumption and risk of colorectal cancer.Jun 30, 2019

Antitumor activities of Grifola frondosa polysaccharide.Jul 12, 2021

Antitumor activity of fucoidan: a systematic review and meta-analysis.Nov 30, 2021

Berberine exerted anti-tumor effects in a variety of tumors in vivo.Jun 16, 2019

Lycopene inhibits liver cancer cell growth.Jan 01, 2005

S. crispa extracts are useful for prevention and treatment of human diseases.May 15, 2018

Sulforaphane and EGCG restore estrogen receptor expression by modulating epigenetic events in the breast cancer cell line MDA-MB-231.Oct 17, 2017

Cancer stem cells as a prognostic biomarker and therapeutic target using curcumin/ piperine extract for multiple myeloma.Sep 30, 2022

A presurgical study of lecithin formulation of green tea extract in women with early breast cancer.May 31, 2017

A case report of a female patient who demonstrated disease response after declining standard therapy and taking a combination of Laetrile and CBD oil.Jul 31, 2019

Artesunate has anti-proliferative properties in colorectal cancer and is generally well tolerated.Dec 31, 2014

Beta-cryptoxanthin synergistically enhances the antitumoral activity of oxaliplatin.Sep 30, 2015

Chinese motherwort has cytotoxicity against human breast cancer cells that is non-apoptic and estrogen receptor independent. Mar 18, 2009

Curcumin selectively induces programmed cell death in cutaneous T-cell lymphoma cell lines and in peripheral blood mononuclear cells (PBMCs).Aug 01, 2010

Curcumin suppresses of phosphorylase kinase activity which is correlated to a resolution of psoriasis. Nov 01, 2000

Curcuminoids could be coadjuvants that might help fight breast cancer upon regular consumption.May 31, 2021

Danggui can prolong the survival rate of gastric cancer patients in Taiwan.Dec 31, 2017

DDW was administered as an oral anticancer agent in addition to conventional therapy, and noticeably prolonged the survival time of all 4 lung cancer patients with brain metastasis.Aug 31, 2008

Deuterium depletion inhibits cell proliferation, RNA and nuclear membrane turnover to enhance survival in pancreatic cancer.Dec 31, 2020

Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.Dec 31, 2011

Effect of acute exercise on prostate cancer cell growth.Dec 31, 2012

Evidence of an inhibitory effect of diet and exercise on prostate cancer cell growth.Aug 31, 2001

Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.Mar 31, 2013

Genistein induces long-term expression of progesterone receptor regardless of estrogen receptor status and improves the prognosis of endometrial cancer patients.Jun 17, 2022

Grape seed procyanidin extract mediates antineoplastic effects against lung cancer.Nov 30, 2016

Green tea drinkers with susceptible IGF1 (CA)19/(CA)19 and (CA)19/X genotypes had a significant reduced risk of lung cancer.Jan 01, 2012

High dose parenteral ascorbate inhibited pancreatic cancer growth and metastasis.Jan 06, 2017

HLA-DQ2/8 genes may not cause gluten-associated villous atrophy, rather, be activated as a consequence of the pathological process. Dec 31, 2004

Hyperbaric oxygen therapy may be an appropriate therapeutic regimen for the treatment of patients with osteosarcoma.Nov 01, 2009

Immuno-stimulating activity of 1,25-dihydroxyvitamin D in blasts from five patients with leukemias and pre-leukemic states.Mar 29, 2023

Inhibition of fibroblast proliferation in vitro using red light-emitting diodes.Jul 31, 2013

Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration.Apr 29, 2024

Metabolised pycnogenol induces apoptosis in human fibrosarcoma cells.Mar 31, 2015

Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption.Feb 16, 2015

Molecular iodine-treated tumors exhibit less invasive potential, and significant increases in apoptosis, estrogen receptor expression, and immune cell infiltration.Jul 16, 2019

N-acetylcysteine compares favorably to metformin on mammographic density in postmenopausal women.Dec 31, 2011

Naringenin from Citrus aurantium inhibits osteosarcoma progression.Dec 31, 2017

Percutaneous Exposures of volunteers to polychromatic light (480-3400 nm) trigger systemic mechanism of the human myeloma cells growth delay.Sep 29, 2019

Photodynamic therapy Using IR-783 liposomes for advanced tongue and breast cancers in humans.Dec 01, 2024

Resveratrol reduces tumor cell proliferation in colorectal patients.Feb 01, 2008

Shikonin could inhibit the growth of lung cancer and improve the immune function of the body and could be a safe and effective treatment.Sep 30, 1991

Sinecatechins 10% ointment presents a botanically based alternative to currently available treatments for EGWs that offers a satisfactory balance of clearance rates, reduced frequency of lesion recurrence.Dec 31, 2014

Supplementation with fish oil for the first 9 weeks of chemotherapy may contribute to delay in tumor progression in colorectal patients.Dec 22, 2015

Supplementing sorafenib with vitamin K may produce synergistic therapeutic effects against hepatocellular carcinoma.Jan 31, 2015

The median survival time of patients in the deuterium depleted water consuming group was 2-4 times longer than it is generally observed in lung cancer patients.Dec 31, 2012

These pilot data suggest that a flaxseed-supplemented, fat-restricted diet may affect prostate cancer biology and associated biomarkers.Jun 30, 2001

Vitamin D may have therapeutic value as an alternative to HRT for vaginal atrophy.Sep 29, 2017

Vitamin D may have therapeutic value as an alternative to HRT for vaginal atrophy.Sep 29, 2017

1,3,4-tri-O-galloyl-6-O-caffeoyl-β-D-glucopyranose, a New Anti-Proliferative Ellagitannin, Regulates the Expression of microRNAs in HepG(2) Cancer Cells.Oct 01, 2011

6-gingerol a component of ginger is extensively metabolized in H-1299 human lung cancer cells.Nov 13, 2012

A Black Raspberry extract could prevent the initiation, promotion, and progression of carcinogenesis in the digestive tract and esophagus.Oct 27, 2014

A diet rich in sulforaphane and related mustard oils may be considered as a supportive nutritional strategy to enhance therapeutic efficacy in patients suffering from pancreatic cancer.Mar 29, 2014

A Nigella sativa extract showed a 88.3% inhibition of proliferation of SiHa human cervical cancer cells and increased the expression of caspase-3, -8 and -9 several-foldJan 31, 2013

An ethanolic extract of T. camphoratus treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin.Dec 31, 2014

An extract of Amla fruit inhibited human papillomavirus viral oncogenes responsible for development and progression of cervical cancer.Dec 31, 2012

An extract of Rosmarinus officinals L. was able to efficiently reduce the proliferation of the human melanoma A375 cells.Dec 31, 2014

Anandamide is a potent and selective inhibitor of the proliferation of breast cancer cells.Jul 06, 1998

Angelica sinesis extracts display antiproliferative, anti-inflammatory, anti-mutagenic effects in vitro.Mar 01, 2018

Antiproliferative and proapoptotic effects of erucin, a diet-derived H2S donor, on human melanoma cells.Dec 25, 2022

Apigenin could be a useful compound to prevent proliferation and migration of cancer cells as well as cancer stem cells.Aug 24, 2016

Apigenin highly upregulated the expression of cytokine genes and induced apoptosis in human pancreatic cancer cells.Nov 30, 2013

Apigenin is a novel therapeutic candidate for melanoma.Feb 13, 2017

Apigenin is a promising chemotherapeutic agent that may be used in the treatment of human osteosarcoma.Jul 31, 2015

Arctigenin is able to inhibit cell proliferation and may induce apoptosis and cell cycle arrest at the G0/G1 phase in glioma cells.Jan 31, 2017

B.infantis enhances immunotherapy for Guillain-Barre syndrome through regulating PD-1.Jan 27, 2023

Berberine may serve as a potential therapeutic option for patients with psoriasis.Mar 19, 2019

Berberine suppressed the progression of human glioma cells.Dec 31, 2021

Bisdemethoxycurcumin induced changes in gene expression that may reveal cytotoxic information on the genetic level.Jan 10, 2015

Blue LED irradiation induces apoptotic cell death by activating the mitochondria-mediated pathway and reduces the early growth rate of melanoma cells.Dec 31, 2014

Antiproliferative

View the Evidence:
7535 Abstracts with Antiproliferative Research