Anxiolytic

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51 Substances Researched for Anxiolytic
NameACCKFocus
Kava Kava774Locked
Lavender434Locked
Chamomile330Locked
Arginine220Locked
Ayahuasca120Locked
Lavender: Essential Oil220Locked
Lysine220Locked
Psilocybin120Locked
Rose 120Locked
Valerian314Locked
Magnolia313Locked
Melissa (Lemonbalm)212Locked
Cannabidiol211Locked
Ayurvedic Formulations110Locked
Bach Flower Remedies110Locked
Cannabis110Locked
Echium amoenum110Locked
Gotu Kola110Locked
Gourd110Locked
Lion's Mane (Hericium Erinaceus)110Locked
Lysergic Acid Diethylamide (LSD)110Locked
Melatonin110Locked
Motherwort110Locked
Passion Flower110Locked
Phellodendron110Locked
Pumpkin Seed Oil/Meal110Locked
Rhodiola (Tibetan Ginseng)110Locked
Skullcap: Blue110Locked
Sweet Orange110Locked
Tryptophan110Locked
Angelica24Locked
Astaxanthin12Locked
Bifidobacterium Longum 12Locked
Black Pepper12Locked
Curcumin12Locked
DHA (Docosahexaenoic Acid)12Locked
Damiana12Locked
Echinacea12Locked
Fish Oil12Locked
Homeopathic Treatment: Pulsatilla nigricans12Locked
Horsetail12Locked
Lemon12Locked
Linden (Tilia)12Locked
Lotus 12Locked
Luteolin12Locked
Neem12Locked
Progesterone12Locked
Salvia divinorum12Locked
Theanine12Locked
Noni11Locked
Ziziphus spinosa11Locked

View the Evidence:
66 Abstracts with Anxiolytic Research

[+]

Kava Kava appears to be a short-term treatment for anxiety, but not a replacement for prolonged anti-anxiety use. Oct 31, 2018

Pubmed Data : Complement Ther Clin Pract. 2018 Nov ;33:107-117. Epub 2018 Sep 15. PMID: 30396607
Article Published Date : Oct 31, 2018
Study Type : Meta Analysis, Review
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Plant Extracts
[+]

Lavender and rose oil aromatherapy has been determined to have anti-anxiety activity.Jan 01, 2010

Pubmed Data : Rev Neurosci. 2010;21(2):141-52. PMID: 20614803
Article Published Date : Jan 01, 2010
Study Type : Meta Analysis
Additional Links
Substances : Lavender, Rose
Diseases : Anxiety Disorders, Generalized Anxiety Disorder
Therapeutic Actions : Aromatherapy
Pharmacological Actions : Anxiolytic
[+]

Systematic review: psychedelics appear to be effective in significantly reducing symptoms of depression and anxiety and are well-tolerated.Jul 29, 2019

Pubmed Data : J Affect Disord. 2019 Jul 30 ;258:11-24. Epub 2019 Jul 30. PMID: 31382100
Article Published Date : Jul 29, 2019
Study Type : Meta Analysis
Additional Links
Substances : Ayahuasca, Psilocybin
Diseases : Depression
Pharmacological Actions : Antidepressive Agents, Anxiolytic
[+]

The current weight of evidence supports the use of kava in treatment of anxiety with a significant result occurring in four out of six studies reviewed.Jan 01, 2011

Pubmed Data : Aust N Z J Psychiatry. 2011 Jan;45(1):27-35. Epub 2010 Nov 15. PMID: 21073405
Article Published Date : Jan 01, 2011
Study Type : Meta Analysis
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

This meta-analysis showed a significant improvement in sleep quality and generalized anxiety disorder.Jun 01, 2019

Pubmed Data : Phytother Res. 2019 Jun ;33(6):1604-1615. Epub 2019 Apr 21. PMID: 31006899
Article Published Date : Jun 01, 2019
Study Type : Meta Analysis
Additional Links
Diseases : Anxiety Disorders, Sleep Disorders
Pharmacological Actions : Anxiolytic
[+]

432 Hz Music has an anxiolytic effect in the treatment of endodontic treatment.Aug 31, 2016

Pubmed Data : J Endod. 2016 Sep ;42(9):1338-43. Epub 2016 Jul 16. PMID: 27430941
Article Published Date : Aug 31, 2016
Study Type : Human Study
Additional Links
Diseases : Anxiety, Root Canal Therapy
Therapeutic Actions : Music
Pharmacological Actions : Anxiolytic
Anti Therapeutic Actions : Dental Interventions, Root Canal
[+]

A combination of Magnolia and Phellodendron reduces symptoms of stress and anxiety in premenopausal women.Sep 01, 2005

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2098-105. PMID: 18426577
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Substances : Magnolia, Phellodendron
Diseases : Anxiety Disorders, Premenopausal Disorders, Stress
Pharmacological Actions : Anxiolytic
Additional Keywords : Plant Extracts
[+]

Bach flower remedies appear to reduce anxiety in human subjects.Jul 01, 2001

Pubmed Data : J Anxiety Disord. 2001 Jul-Aug;15(4):359-66. PMID: 11474820
Article Published Date : Jul 01, 2001
Study Type : Human Study
Additional Links
Substances : Bach Flower Remedies
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Plant Extracts
[+]

Blue skullcap (S. lateriflora) demonstates anti-anxiety activity in human subjects. Mar 01, 2003

Pubmed Data : Altern Ther Health Med. 2003 Mar-Apr;9(2):74-8. PMID: 12652886
Article Published Date : Mar 01, 2003
Study Type : Human Study
Additional Links
Substances : Skullcap: Blue
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Cannabidiol reduces anxiety in social anxiety disorder through modulating the limbic and paralimbic brain areas. Sep 09, 2010

Pubmed Data : J Psychopharmacol. 2010 Sep 9. Epub 2010 Sep 9. PMID: 20829306
Article Published Date : Sep 09, 2010
Study Type : Human Study
Additional Links
Substances : Cannabidiol, Cannabis
Diseases : Anxiety Disorders, Social Anxiety Disorder (SAD)
Pharmacological Actions : Anxiolytic
[+]

Chamomile extract has a positive effect in reducing symptoms in patients with generalized anxiety disorder. Aug 01, 2009

Pubmed Data : J Clin Psychopharmacol. 2009 Aug;29(4):378-82. PMID: 19593179
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Chamomile
Diseases : Anxiety: Generalized, Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Chamomile improves cortisol patterns in subjects with moderate to severe generalized anxiety disorder.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Psychiatr Res. 2018 01 ;96:189-195. Epub 2017 Oct 16. PMID: 29080520
Article Published Date : Jan 01, 2018
Study Type : Human Study
Additional Links
Substances : Chamomile
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Chamomile may provide clinically meaningful antidepressant activity that occurs in addition to its previously observed anxiolytic activity.Aug 31, 2012

Pubmed Data : Altern Ther Health Med. 2012 Sep-Oct;18(5):44-9. PMID: 22894890
Article Published Date : Aug 31, 2012
Study Type : Human Study
Additional Links
Substances : Chamomile
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Antidepressive Agents, Anxiolytic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study.May 31, 2012

Pubmed Data : J Altern Complement Med. 2012 Jun ;18(6):612-21. PMID: 22784349
Article Published Date : May 31, 2012
Study Type : Human Study
Additional Links
Substances : Ayurvedic Formulations
Diseases : Anxiety Disorders
Therapeutic Actions : Ayurvedic Medicine
Pharmacological Actions : Anxiolytic
Additional Keywords : Phytotherapy, Plant Extracts, Superiority of Natural Substances versus Drugs
Problem Substances : Benzodiazepines, Clonazepam
[+]

Echium amoenum may have therapeutic value in the treatment of obessive-compulsive disorder.Dec 01, 2006

Pubmed Data : Integr Cancer Ther. 2006 Dec;5(4):362-72. PMID: 19737592
Article Published Date : Dec 01, 2006
Study Type : Human Study
Additional Links
Substances : Echium amoenum
Diseases : Obsessive-Compulsive Disorder
Pharmacological Actions : Anxiolytic
[+]

EFT results in reduced psychological stress and cortisol in human subjects.Sep 30, 2012

Pubmed Data : J Nerv Ment Dis. 2012 Oct ;200(10):891-6. PMID: 22986277
Article Published Date : Sep 30, 2012
Study Type : Human Study
Additional Links
Diseases : Anxiety Disorders, Cortisol: High
Therapeutic Actions : Emotional Freedom Technique
Pharmacological Actions : Anxiolytic
[+]

Emotional freedom techniques improves multiple physiological markers of health.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Evid Based Integr Med. 2019 Jan-Dec;24:2515690X18823691. PMID: 30777453
Article Published Date : Dec 31, 2018
Study Type : Human Study
Additional Links
Diseases : Anxiety, Post-Traumatic Stress Disorders (PTSD)
Therapeutic Actions : Emotional Freedom Technique
Pharmacological Actions : Antihypertensive Agents, Anxiolytic
[+]

Emotional Freedom Techniques show promise as feasible treatments for test anxiety.Oct 31, 2009

Pubmed Data : Explore (NY). 2009 Nov-Dec;5(6):338-40. PMID: 19913760
Article Published Date : Oct 31, 2009
Study Type : Human Study
Additional Links
Diseases : Anxiety Disorders
Therapeutic Actions : Emotional Freedom Technique
Pharmacological Actions : Anxiolytic
[+]

Gotu kola may have therapeutic efficacy in the treatment of anxiety syndromes.Dec 01, 2000

Pubmed Data : J Clin Psychopharmacol. 2000 Dec;20(6):680-4. PMID: 11106141
Article Published Date : Dec 01, 2000
Study Type : Human Study
Additional Links
Substances : Gotu Kola
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Hericium erinaceus intake results in a reduction of depression and anxiety in mice by 4 weeks. Aug 01, 2010

Pubmed Data : Biomed Res. 2010 Aug ;31(4):231-7. PMID: 20834180
Article Published Date : Aug 01, 2010
Study Type : Human Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Anxiolytic
[+]

Kava is safe and effective in treating anxiety disorders and depression.Aug 01, 2009

Pubmed Data : Psychopharmacology (Berl). 2009 Aug;205(3):399-407. Epub 2009 May 9. PMID: 19430766
Article Published Date : Aug 01, 2009
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Antidepressive Agents, Anxiolytic
Additional Keywords : Plant Extracts
[+]

Kava was judged to be an effective and safe treatment of non-psychotic anxiety syndrome.Apr 01, 2004

Pubmed Data : Phytother Res. 2004 Apr;18(4):297-300. PMID: 15162364
Article Published Date : Apr 01, 2004
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Kava was judged to improve the mood, particularly by reducing anxiety in perimenopausal women.Dec 01, 2008

Pubmed Data : Integr Cancer Ther. 2008 Dec;7(4):295-310. PMID: 12590005
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders, Perimenopausal Syndrome
Pharmacological Actions : Anxiolytic
[+]

Lavender essence has a positive effect on anxiety and blood cortisol level among patients about to undergo open heart surgery. Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Nurs Midwifery Res. 2016 Jul-Aug;21(4):397-401. PMID: 27563324
Article Published Date : Jun 30, 2016
Study Type : Human Study
Additional Links
Substances : Lavender: Essential Oil
Diseases : Anxiety Disorders, Cortisol: High
Pharmacological Actions : Anxiolytic
[+]

LSD can reduce anxiety.Mar 02, 2014

Pubmed Data : J Nerv Ment Dis. 2014 Mar 3. Epub 2014 Mar 3. PMID: 24594678
Article Published Date : Mar 02, 2014
Study Type : Human Study
Additional Links
Substances : Lysergic Acid Diethylamide (LSD)
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Melatonin and to a lesser degree mothewort decrease retinal sensitivity and improves the emotional state in anxious young subjects.Nov 01, 2006

Pubmed Data : Eksp Klin Farmakol. 2006 Nov-Dec;69(6):17-9. PMID: 17209457
Article Published Date : Nov 01, 2006
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Anxiety Disorders, Retinal Diseases, Retinal Sensitivity
Pharmacological Actions : Anxiolytic
Additional Keywords : Plant Extracts
[+]

Melissa officinalis and Valeriana officinalis have an anti-anxiety effect during laboratory-induced stress. Feb 01, 2006

Pubmed Data : Phytother Res. 2006 Feb;20(2):96-102. PMID: 16444660
Article Published Date : Feb 01, 2006
Study Type : Human Study
Additional Links
Substances : Melissa (Lemonbalm), Valerian
Diseases : Anxiety Disorders, Stress
Pharmacological Actions : Anxiolytic
Additional Keywords : Plant Extracts
[+]

Motherwort improves symptoms of anxiety and depression in patients with arterial hypertension.Apr 01, 2011

Pubmed Data : Phytother Res. 2011 Apr;25(4):540-3. Epub 2010 Sep 13. PMID: 20839214
Article Published Date : Apr 01, 2011
Study Type : Human Study
Additional Links
Substances : Motherwort
Diseases : Anxiety Disorders, Depression, Hypertension
Pharmacological Actions : Antidepressive Agents, Anxiolytic
[+]

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans.Apr 01, 2007

Pubmed Data : Biomed Res. 2007 Apr;28(2):85-90. PMID: 17510493
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : Arginine, Lysine
Diseases : Anxiety Disorders, Cortisol: High
Pharmacological Actions : Anxiolytic
[+]

Passionflower as a premedication reduces anxiety without inducing sedation.Jun 01, 2008

Pubmed Data : Anesth Analg. 2008 Jun;106(6):1728-32. PMID: 18499602
Article Published Date : Jun 01, 2008
Study Type : Human Study
Additional Links
Substances : Passion Flower
Diseases : Anxiety: Preoperative, Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Rhodiola rosea significantly improves generalized anxiety disorder (GAD)Mar 01, 2008

Pubmed Data : J Altern Complement Med. 2008 Mar;14(2):175-80. PMID: 18307390
Article Published Date : Mar 01, 2008
Study Type : Human Study
Additional Links
Substances : Rhodiola (Tibetan Ginseng)
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder.Aug 31, 2010

Pubmed Data : Int Clin Psychopharmacol. 2010 Sep ;25(5):277-87. PMID: 20512042
Article Published Date : Aug 31, 2010
Study Type : Human Study
Additional Links
Substances : Lavender
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Phytotherapy
[+]

Subchronic treatment with amino acid mixture of L-lysine and L-arginine may have ameliorative value during psychosocial stress.Jun 01, 2005

Pubmed Data : Nutr Neurosci. 2005 Jun;8(3):155-60. PMID: 16117182
Article Published Date : Jun 01, 2005
Study Type : Human Study
Additional Links
Substances : Arginine, Lysine
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Sweet orange essential oil has anti-anxiety properties.Jul 31, 2012

Pubmed Data : J Altern Complement Med. 2012 Aug ;18(8):798-804. Epub 2012 Jul 31. PMID: 22849536
Article Published Date : Jul 31, 2012
Study Type : Human Study
Additional Links
Substances : Sweet Orange
Diseases : Anxiety Disorders
Therapeutic Actions : Aromatherapy
Pharmacological Actions : Anxiolytic
Additional Keywords : Plant Extracts
[+]

The inhalation of lavender oil has stress reducing effects. Mar 31, 2012

Pubmed Data : J Med Assoc Thai. 2012 Apr ;95(4):598-606. PMID: 22612017
Article Published Date : Mar 31, 2012
Study Type : Human Study
Additional Links
Substances : Lavender: Essential Oil
Diseases : Stress and Anxiety
Therapeutic Actions : Aromatherapy
Pharmacological Actions : Anxiolytic
[+]

The practice of asanas and yoga decreased anxiety in women.Jan 16, 2014

Pubmed Data : West Indian Med J. 2014 Jan 17 ;63(1):83-85. Epub 2014 Jan 17. PMID: 25303199
Article Published Date : Jan 16, 2014
Study Type : Human Study
Additional Links
Diseases : Anxiety Disorders, Anxiety States: Neurotic, Stress and Anxiety
Therapeutic Actions : Yoga
Pharmacological Actions : Anxiolytic
[+]

Tryptophan-rich gourd seeds are a potential anxiolytic to those suffering from social phobia.Sep 01, 2007

Pubmed Data : Can J Physiol Pharmacol. 2007 Sep;85(9):928-32. PMID: 18066139
Article Published Date : Sep 01, 2007
Study Type : Human Study
Additional Links
Substances : Gourd, Pumpkin Seed Oil/Meal, Tryptophan
Diseases : Anti-Social Behavior, Anxiety Disorders, Phobia: Social
Pharmacological Actions : Anxiolytic
[+]

A methanolic extract of Piper nigrum ameliorates beta-amyloid (1–42)-induced anxiety and depression by attenuation of the oxidative stress in the rat amygdala.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Behav Brain Funct. 2015 ;11:13. Epub 2015 Mar 29. PMID: 25880991
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Black Pepper
Diseases : Alzheimer's Disease, Anxiety Disorders, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Anxiolytic, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Angelica root coumarins display synergistic anxiolytic activity.Jan 10, 2013

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10 ;40:180-6. Epub 2012 Aug 29. PMID: 22960104
Article Published Date : Jan 10, 2013
Study Type : Animal Study
Additional Links
Substances : Angelica
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Plant Extracts
[+]

Angelica whole plant and leaf display the highest anxiolytic activity whereas the root, fruit, intermediate, and stem display the least.Jul 01, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Tradit Complement Med. 2012 Jul ;2(3):235-41. PMID: 24716138
Article Published Date : Jul 01, 2012
Study Type : Animal Study
Additional Links
Substances : Angelica
Diseases : Anxiety
Pharmacological Actions : Anxiolytic
[+]

Astaxanthin prevents fish-oil induced oxidative stress in the anterior forebrain of animals, resulting in an anxiety reducing effect. May 17, 2011

Pubmed Data : Pharmacol Biochem Behav. 2011 May 17;99(3):349-355. Epub 2011 May 17. PMID: 21619892
Article Published Date : May 17, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Anxiolytic, Neuroprotective Agents
[+]

Bifidobacterium longum's anxiolytic effect involves vagal pathways for gut-brain communication.Dec 01, 2011

Pubmed Data : Neurogastroenterol Motil. 2011 Dec ;23(12):1132-9. Epub 2011 Oct 11. PMID: 21988661
Article Published Date : Dec 01, 2011
Study Type : Animal Study
Additional Links
Substances : Bifidobacterium Longum
Diseases : Anxiety Disorders, Gut Brain Axis: Imbalance
Pharmacological Actions : Anxiolytic
[+]

Citrus limon has significant behavioral effects in rats, including anxiety reduction.Sep 16, 2014

Pubmed Data : Metab Brain Dis. 2014 Sep 17. Epub 2014 Sep 17. PMID: 25227172
Article Published Date : Sep 16, 2014
Study Type : Animal Study
Additional Links
Substances : Lemon
Diseases : Anxiety Disorders, Stress and Anxiety
Pharmacological Actions : Anxiolytic
[+]

Curcumin has anti-anxiety properties.Sep 17, 2010

Pubmed Data : Brain Res. 2010 Sep 17;1352:167-75. Epub 2010 Jul 12. PMID: 20633542
Article Published Date : Sep 17, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Damiana exhibits anti-anxiety activity in mice. - Article 1Jan 01, 2005

Pubmed Data : J Herb Pharmacother. 2005;5(4):13-21. PMID: 16635964
Article Published Date : Jan 01, 2005
Study Type : Animal Study
Additional Links
Substances : Damiana
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Echinacea has anti-anxiety properties.Nov 01, 2010

Pubmed Data : Phytother Res. 2010 Nov;24(11):1605-13. PMID: 21031616
Article Published Date : Nov 01, 2010
Study Type : Animal Study
Additional Links
Substances : Echinacea
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect.May 02, 2011

Pubmed Data : J Nutr Biochem. 2011 May 2. Epub 2011 May 2. PMID: 21543216
Article Published Date : May 02, 2011
Study Type : Animal Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), Fish Oil
Diseases : Postpartum Problems, Prenatal Nutrition
Pharmacological Actions : Anxiolytic
[+]

Horsetail possesses anxiolytic properties.May 01, 2011

Pubmed Data : Indian J Exp Biol. 2011 May ;49(5):352-6. PMID: 21615059
Article Published Date : May 01, 2011
Study Type : Animal Study
Additional Links
Substances : Horsetail
Diseases : Anxiety
Pharmacological Actions : Anxiolytic
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Kava compares favorably with diazepam in reducing anxiety in mice. Jun 01, 2002

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jun;26(5):855-60. PMID: 12369257
Article Published Date : Jun 01, 2002
Study Type : Animal Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Benzodiazepine Alternatives, Plant Extracts, Superiority of Natural Substances versus Drugs
[+]

Kava exhibits anxiolytic properties in mice.Oct 01, 2003

Pubmed Data : Psychopharmacology (Berl). 2003 Oct;170(1):33-41. Epub 2003 Jul 4. PMID: 12845414
Article Published Date : Oct 01, 2003
Study Type : Animal Study
Additional Links
Substances : Kava Kava
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Plant Extracts
[+]

L-theanine works synergistically with the drug midazolam to induce an anxiolytic effect. Aug 01, 2010

Pubmed Data : J Altern Complement Med. 2010 Aug;16(8):875-82. PMID: 20108732
Article Published Date : Aug 01, 2010
Study Type : Animal Study
Additional Links
Substances : Theanine
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Drug: Midazolam, Drug-Plant-Vitamin Synergies
[+]

Luteolin, a lemon blam flavonoid, may contribute to reducing anxiety through modulating motor movements and locomotion. Feb 01, 2009

Pubmed Data : AANA J. 2009 Feb;77(1):33-6. PMID: 19263826
Article Published Date : Feb 01, 2009
Study Type : Animal Study
Additional Links
Substances : Luteolin, Melissa (Lemonbalm)
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Magnolia officinalis has anxiolytic properties.Apr 18, 2011

Pubmed Data : J Med Food. 2011 Apr 18. Epub 2011 Apr 18. PMID: 21501091
Article Published Date : Apr 18, 2011
Study Type : Animal Study
Additional Links
Substances : Magnolia
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic, Benzodiazepine receptor agonist, GABA Modulators
[+]

Neem compare favorably to diazepam in reducing anxiety in mice without motor side effects. Jun 01, 2010

Pubmed Data : West Indian Med J. 2010 Jun;59(3):245-8. PMID: 21291100
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
Additional Keywords : Benzodiazepine Alternatives, Drug: Diazepam, Plant Extracts
[+]

Neferine extracted from Lotus seed has sedative anti-anxiety effects.Dec 01, 2008

Pubmed Data : Phytomedicine. 2008 Dec;15(12):1117-24. PMID: 19010651
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Lotus
Diseases : Anxiety Disorders, Seizures
Pharmacological Actions : Anxiolytic, Hypnotics and Sedatives
Additional Keywords : Plant Extracts
[+]

Progesterone is able to decrease anxiety behavior in younger and older mice. Jun 01, 2006

Pubmed Data : Psychopharmacology (Berl). 2006 Jun;186(3):312-22. Epub 2006 Mar 15. PMID: 16538472
Article Published Date : Jun 01, 2006
Study Type : Animal Study
Additional Links
Substances : Progesterone
Diseases : Aging, Generalized Anxiety Disorder
Pharmacological Actions : Anxiolytic
[+]

Salvinorin A, a compound found within Salvia divinorum, exhibits anxiolytic and antidepressant-like properties. Jul 01, 2009

Pubmed Data : Br J Pharmacol. 2009 Jul;157(5):844-53. Epub 2009 May 5. PMID: 19422370
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Salvia divinorum
Diseases : Anxiety Disorders, Depression
Pharmacological Actions : Antidepressive Agents, Anxiolytic
[+]

Serotonin modulation contributes to the anxiolytic-like effect of inhalation of essential oil from Lavandula officinalis.Jun 30, 2014

Pubmed Data : Nat Prod Commun. 2014 Jul ;9(7):1023-6. PMID: 25230519
Article Published Date : Jun 30, 2014
Study Type : Animal Study
Additional Links
Substances : Lavender
Diseases : Anxiety Disorders, Serotonin Disorders
Pharmacological Actions : Anxiolytic, Serotonergic
[+]

The anxiolytic-like effect of lavender essential oil inhalation in mice is due to the modulation of serotonergic pathways.May 19, 2013

Pubmed Data : J Ethnopharmacol. 2013 May 20 ;147(2):412-8. Epub 2013 Mar 22. PMID: 23524167
Article Published Date : May 19, 2013
Study Type : Animal Study
Additional Links
Substances : Lavender
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic, Serotonergic
[+]

The homeopathic remedy Pulsatilla nigricans compares favorably as an anti-anxiety agent to diazepam (Valium). Jun 30, 2012

Pubmed Data : Homeopathy. 2012 Jul ;101(3):171-4. PMID: 22818235
Article Published Date : Jun 30, 2012
Study Type : Animal Study
Additional Links
Substances : Homeopathic Treatment: Pulsatilla nigricans
Diseases : Anxiety Disorders
Therapeutic Actions : Homeopathic Treatment
Pharmacological Actions : Anxiolytic
Additional Keywords : Natural Substances Versus Drugs
[+]

Tilia var. mexicana has anti-anxiety activity without affecting motor activity.Jul 23, 2008

Pubmed Data : J Ethnopharmacol. 2008 Jul 23;118(2):312-7. Epub 2008 Apr 24. PMID: 18539420
Article Published Date : Jul 23, 2008
Study Type : Animal Study
Additional Links
Substances : Linden (Tilia)
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Valerian's anti-anxiety action is due to its action on GABA receptors.Jun 17, 2008

Pubmed Data : Neuropharmacology. 2008 Jun 17. PMID: 18602406
Article Published Date : Jun 17, 2008
Study Type : Animal Study
Additional Links
Substances : Valerian
Diseases : Anxiety: Generalized, Anxiety Disorders, Generalized Anxiety Disorder
Pharmacological Actions : Anxiolytic, GABA Modulators
[+]

Valeriana officinalis root extracts have potent anxiolytic effects in rats.Dec 28, 2009

Pubmed Data : Phytomedicine. 2009 Dec 28. Epub 2009 Dec 28. PMID: 20042323
Article Published Date : Dec 28, 2009
Study Type : Animal Study
Additional Links
Substances : Valerian
Diseases : Anxiety Disorders
Pharmacological Actions : Anxiolytic
[+]

Magnolia and Ziziphus extracts modulate central nervous system receptors in a manner consistent with their traditional use as anxiolytic and sleep-inducing. Jul 30, 2009

Pubmed Data : J Ethnopharmacol. 2009 Jul 30;124(3):421-5. Epub 2009 Jun 6. PMID: 19505549
Article Published Date : Jul 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Magnolia, Ziziphus spinosa
Diseases : Anxiety Disorders, Insomnia
Pharmacological Actions : Anxiolytic, Benzodiazepine receptor agonist
Additional Keywords : Benzodiazepine Receptor Agonist
[+]

Noni may reduce anxiety via affinity with GABA receptors.Aug 01, 2007

Pubmed Data : Phytomedicine. 2007 Aug;14(7-8):517-22. Epub 2007 Jun 11. PMID: 17561385
Article Published Date : Aug 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Noni
Diseases : Anxiety Disorders, Generalized Anxiety Disorder
Pharmacological Actions : Anxiolytic, GABA Modulators
[+]

Studies assessed in the present chapter clearly suggest an anxiolytic-like effect of CBD in both animal models and healthy volunteers.May 08, 2016

Pubmed Data : Curr Neuropharmacol. 2016 May 9. Epub 2016 May 9. PMID: 27157263
Article Published Date : May 08, 2016
Study Type : Review
Additional Links
Substances : Cannabidiol
Diseases : Anxiety Disorders
Pharmacological Actions : Anti-Anxiety Agents, Anxiolytic

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