Aromatase Inhibitors

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35 Substances Researched for Aromatase Inhibitors
NameACCKFocus
Astaxanthin110Locked
Saw Palmetto110Locked
Enterodiol33Locked
Grape Seed Extract23Locked
Lignans33Locked
Melatonin33Locked
Enterolactone22Locked
Ginkgo biloba12Locked
Hops22Locked
Licorice22Locked
Medicinal Mushrooms12Locked
Onion12Locked
Pomegranate22Locked
Red Wine Extract22Locked
White Button Mushroom 22Locked
Bai Zhu11Locked
Beer11Locked
Biochanin A11Locked
Chrysin11Locked
Daidzein11Locked
Damiana11Locked
Euonymus alatus (Burning Bush)11Locked
Flavonoids11Locked
Flaxseed11Locked
Genistein11Locked
Maca11Locked
Mangosteen11Locked
Nobiletin 11Locked
Red Clover11Locked
Resveratrol11Locked
Sculletaria barbata11Locked
Secoisolariciresinol diglucoside (SDG)11Locked
Yerba Mate11Locked
phytoestrogens11Locked
Cactus Flower10Locked

View the Evidence:
33 Abstracts with Aromatase Inhibitors Research

[+]

A dietary supplement containing astaxanthin and saw palmetto berry extract decrease dihydrotestosterone, increase testosterone and decrease estradiol levels in healthy males. Sep 01, 2009

Pubmed Data : J Cardiovasc Electrophysiol. 2009 Sep;20(9):1055-60. Epub 2009 Apr 30. PMID: 18700016
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Substances : Astaxanthin, Saw Palmetto
Diseases : Low Testosterone, Male Hormone Imbalances, Testosterone: Too Low
Pharmacological Actions : Aromatase Inhibitors
Additional Keywords : DHT Blocker
[+]

Ginkgo biloba may be a useful aromatase inhibitor for the treatment for estrogen-sensitive breast cancer.Dec 31, 2015

Pubmed Data : Food Chem Toxicol. 2016 Jan ;87:157-65. Epub 2015 Dec 17. PMID: 26706698
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Aromatase Inhibitors
Additional Keywords : Plant Extracts
[+]

Grapeseed inhibits aromatase activity in an animal model of mammary cancer. Jun 01, 2006

Pubmed Data : Cancer Res. 2006 Jun 1;66(11):5960-7. PMID: 16740737
Article Published Date : Jun 01, 2006
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

Hispolon could be useful in the treatment of breast cancers or other gynecologic diseases.Dec 31, 2016

Pubmed Data : Int J Med Mushrooms. 2017 ;19(3):233-242. PMID: 28605338
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Medicinal Mushrooms
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors, Cyclooxygenase 2 Inhibitors
[+]

Welsh onion root restores ovarian functions from letrozole induced-polycystic ovary syndrome.Oct 03, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Oct 4 ;10(10). Epub 2018 Oct 4. PMID: 30287740
Article Published Date : Oct 03, 2018
Study Type : Animal Study
Additional Links
Substances : Onion
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Aromatase Inhibitors
Additional Keywords : Phytotherapy, Plant Extracts
[+]

"Melatonin suppresses aromatase expression and activity in breast cancer associated fibroblasts."Mar 31, 2012

Pubmed Data : Breast Cancer Res Treat. 2012 Apr ;132(2):765-71. Epub 2012 Jan 12. PMID: 22237979
Article Published Date : Mar 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

Atractylenolide and its derivates may serve as potential aromatase inhibitors.Apr 13, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2011 Apr 14 ;16(4):3146-51. Epub 2011 Apr 14. PMID: 21494203
Article Published Date : Apr 13, 2011
Study Type : In Vitro Study
Additional Links
Substances : Bai Zhu
Pharmacological Actions : Aromatase Inhibitors
Additional Keywords : Plant Extracts
[+]

Chrysin has potency in inhibition of the aromatase enzyme and thus can be useful in preventing and treating the hormone-dependent breast cancer.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2020 Mar ;6(3):e03557. Epub 2020 Mar 7. PMID: 32181408
Article Published Date : Feb 29, 2020
Study Type : Review
Additional Links
Substances : Chrysin
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors, Enzyme Inhibitors
[+]

Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis.Apr 17, 2018

Pubmed Data : J Steroid Biochem Mol Biol. 2018 Apr 18. Epub 2018 Apr 18. PMID: 29679753
Article Published Date : Apr 17, 2018
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Endometriosis
Pharmacological Actions : Anti-Inflammatory Agents, Aromatase Inhibitors, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Damiana contains compounds with anti-aromatase activity. Dec 08, 2008

Pubmed Data : J Ethnopharmacol.2008 Dec 8;120(3):387-93. Epub 2008 Sep 26. PMID: 18948180
Article Published Date : Dec 08, 2008
Study Type : In Vitro Study
Additional Links
Substances : Damiana
Diseases : Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Euonymus altaus and Scutellaria barbarata have prowerful aromatase inhibiting properties.Aug 01, 2004

Pubmed Data : Immunopharmacol Immunotoxicol. 2004 Aug;26(3):315-27. PMID: 15518167
Article Published Date : Aug 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Euonymus alatus (Burning Bush), Sculletaria barbata
Diseases : Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Hops contains compounds which inhibit the aromatase enzyme and estrogen formation, inducing apoptosis in breast cancer cells. Jun 01, 2007

Pubmed Data : J Steroid Biochem Mol Biol. 2007 Jun-Jul;105(1-5):124-30. Epub 2007 Jul 23. PMID: 17643984
Article Published Date : Jun 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Hops
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

Hops rich beer contains flavonoids which inhibit extrogen formation in choriocarcinoma-derived cells. Apr 19, 2006

Pubmed Data : J Agric Food Chem. 2006 Apr 19;54(8):2938-43. PMID: 16608212
Article Published Date : Apr 19, 2006
Study Type : In Vitro Study
Additional Links
Substances : Beer, Hops
Diseases : Choriocarcinoma, Trophoblastic Neoplasms, Trophoblastic Tumor
Pharmacological Actions : Aromatase Inhibitors
[+]

Licorice contains a compound (liquiritigenin) with aromatase inhibitory action 10 times more potent than the first generation aromatase inhibitor aminoglutethimide (Cytadren). Sep 15, 2008

Pubmed Data : Bioorg Med Chem. 2008 Sep 15;16(18):8466-70. Epub 2008 Aug 19. PMID: 18778944
Article Published Date : Sep 15, 2008
Study Type : In Vitro Study
Additional Links
Substances : Licorice
Diseases : Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Lignans and flavonoids act as aromatase inhibitors in human preadipocytes. Aug 01, 1994

Pubmed Data : J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):205-12. PMID: 8049151
Article Published Date : Aug 01, 1994
Study Type : In Vitro Study
Additional Links
Substances : Enterodiol, Flavonoids, Lignans
Diseases : Breast Cancer, Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Mace contains compounds which exhibit antiproliferative, anti-aromatse and anti-17beta-hydroxysteroid dehydrogenase activity. Nov 01, 2001

Pubmed Data : Planta Med. 2001 Nov;67(8):700-4. PMID: 11731908
Article Published Date : Nov 01, 2001
Study Type : In Vitro Study
Additional Links
Substances : Maca
Pharmacological Actions : 17beta-hydroxysteroid dehydrogenase inhibitor, Antiproliferative , Aromatase Inhibitors
[+]

Mammalian lignans and the soy isoflavone genistein inhibit breast cancer via down-regulation of estrogen production. Apr 01, 2005

Pubmed Data : J Steroid Biochem Mol Biol. 2005 Apr;94(5):461-7. Epub 2005 Mar 16. PMID: 15876411
Article Published Date : Apr 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Enterodiol, Enterolactone, Genistein, Lignans
Diseases : Breast Cancer, Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Mangosteen contains xanthones with aromatase inhibitory activity.Jul 01, 2008

Pubmed Data : J Nat Prod. 2008 Jul;71(7):1161-6. Epub 2008 Jun 18. PMID: 18558747
Article Published Date : Jul 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Mangosteen
Diseases : Estrogen Dominance
Pharmacological Actions : Anticarcinogenic Agents, Aromatase Inhibitors
Additional Keywords : Xanthones
[+]

Melatonin could stimulate the differentiation of fibroblasts and reduce the aromatase activity and expression in both fibroblasts and adipocytes, thereby reducing the number of estrogen-producing cells proximal to malignant cells.Dec 31, 2011

Pubmed Data : J Pineal Res. 2012 Jan ;52(1):12-20. Epub 2011 Jul 1. PMID: 21718362
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors, Cell Differentiation Inducer
[+]

Melatonin down-regulates estrogen production in endothelial cells via its anti-aromatase activity.Feb 27, 2013

Pubmed Data : Oncol Rep. 2013 Feb 28. Epub 2013 Feb 28. PMID: 23450505
Article Published Date : Feb 27, 2013
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer, Breast Cancer: Estrogen, Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Aromatase Inhibitors
[+]

Nobiletin decreases the activity and expression of aromatase at low concentrations in MCF-7 breast cancer cells.Jul 31, 2017

Pubmed Data : Biochem Cell Biol. 2017 Aug ;95(4):468-473. Epub 2017 Feb 1. PMID: 28177754
Article Published Date : Jul 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

Pomegranate compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro.Jan 01, 2010

Pubmed Data : Cancer Prev Res (Phila Pa). 2010 Jan;3(1):108-13. PMID: 20051378
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer, Breast Cancer: Prevention
Pharmacological Actions : Antiproliferative , Aromatase Inhibitors
[+]

Pomegranate has potent anti-aromatase activity warranting its use for human breast cancer.Feb 01, 2002

Pubmed Data : Breast Cancer Res Treat. 2002 Feb;71(3):203-17. PMID: 12002340
Article Published Date : Feb 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

Procyandidin from Red Wine and Grape Seeds inhibit androgen-dependant breast cancer turmors by reducing estrogen formation.Dec 01, 2003

Pubmed Data : Cancer Res. 2003 Dec 1;63(23):8516-22. PMID: 14679019
Article Published Date : Dec 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract, Red Wine Extract
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

Red clover demonstrates aromatase inhibition activity, which may reduce the risk of estrogen receptor positive breast cancer.Feb 01, 2008

Pubmed Data : Br J Nutr. 2008 Feb;99(2):303-10. Epub 2007 Aug 29. PMID: 17761019
Article Published Date : Feb 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Red Clover
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

Red wine extract has anti-aromatase activity which abrogates hyperpasia in mammary tissue. May 01, 2001

Pubmed Data : Breast Cancer Res Treat. 2001 May;67(2):133-46. PMID: 11519862
Article Published Date : May 01, 2001
Study Type : In Vitro Study
Additional Links
Substances : Red Wine Extract
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

Resveratrol is a bilevel inhibitor of aromatase in breast cancer cells. Jul 01, 2006

Pubmed Data : Toxicol Sci. 2006 Jul;92(1):71-7. Epub 2006 Apr 11. PMID: 16611627
Article Published Date : Jul 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

The licorice flavonoid isoliquiritgenein inhibits aromatase and is a potential chemopreventive agent in breast cancer. Mar 01, 2009

Pubmed Data : Int J Cancer. 2009 Mar 1;124(5):1028-36. PMID: 19065667
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Licorice
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

The mammalian phytoestrogens enterodiol and enterolactone may protect against breast and prostate cancer through hormone modulating activities.Sep 25, 2002

Pubmed Data : J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):289-309. PMID: 12270221
Article Published Date : Sep 25, 2002
Study Type : Review
Additional Links
Substances : Enterodiol, Enterolactone, Flaxseed, Lignans, phytoestrogens, Secoisolariciresinol diglucoside (SDG)
Diseases : Breast Cancer, Cancers: All, Prostate Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

White button mushrooms have anti-aromatase activity and may provide an idea breast cancer chemopreventive agent. Article 1Dec 01, 2005

Pubmed Data : Mol Cell Biochem. 2005 Dec;280(1-2):173-9. PMID: 17178902
Article Published Date : Dec 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : White Button Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

White button mushrooms have anti-aromatase activity and may provide an ideal breast cancer chemopreventive agent. - Article 2Dec 01, 2001

Pubmed Data : J Nutr. 2001 Dec;131(12):3288-93. PMID: 11739882
Article Published Date : Dec 01, 2001
Study Type : In Vitro Study
Additional Links
Substances : White Button Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Aromatase Inhibitors
[+]

Yerba mate contains a potent aromatase inhibitor. Sep 01, 2008

Pubmed Data : Eur J Med Chem. 2008 Sep;43(9):1865-77. Epub 2007 Dec 7. PMID: 18192087
Article Published Date : Sep 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Yerba Mate
Diseases : Estrogen Dominance
Pharmacological Actions : Aromatase Inhibitors
[+]

Cactus flower extracts may be beneficial in the treatment of benign prostatic hyperplasia. Jan 01, 1998

Pubmed Data : Urol Res.1998;26(4):265-70. PMID: 9760000
Article Published Date : Jan 01, 1998
Additional Links
Substances : Cactus Flower
Diseases : Prostatic Hyperplasia: Benign
Pharmacological Actions : 5-alpha reductase inhibitor, Aromatase Inhibitors

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