Autophagy Inhibitors

Name	AC	CK
Astragaloside	10	14
Ginsenosides	10	14
Flavonoids	9	12
Bee Venom	1	10
Blueberry	1	10
Capsaicin	2	8
Melatonin	5	8
Panax Notoginseng	3	7
Puerarin	4	7
Resveratrol	3	7
Curcumin	4	6
Rutin	3	6
Oleanolic acid	3	5
Arctigenin	3	4
EGCG (Epigallocatechin gallate)	3	4
Luteolin	3	4
Peony	2	4
Quercetin	3	4
Shikonin	2	4
Sulforaphane	2	4
Thymoquinone	4	4
Vitexins	2	4
Berberine	3	3
Crocin	2	3
Naringenin	2	3
Tanshinone IIA	2	3
Tongkat Ali	1	3
Anthocyanins	1	2
Asiatic Acid	1	2
Betulinic acid	1	2
Biochanin A	1	2
Black Pepper	1	2
Chlorogenic Acid	1	2
Delphinidin	2	2
Fucoidan	1	2
Gingerol	2	2
Glycyrrhizin	1	2
Hesperidin	1	2
Honeysuckle	1	2
Honokiol	1	2
Lactobacillus reuteri	1	2
Long Pepper	1	2
Mangiferin	1	2
Mango	2	2
Mulberry	1	2
Oridonin	2	2
Parthenolide	2	2
Patchouli	1	2
Polyphenols	1	2
Psychedelics:All	1	2
Seaweed	1	2
Sinomenine	1	2
St. Johns Wort	1	2
Stigmasterol	1	2
Vitamin C	1	2
Vitamin D	1	2
6-Shogaol	1	1
Adlay	1	1
Allicin	1	1
Aloe Vera	1	1
Alpha-Lipoic Acid	1	1
Andrographolide	1	1
Angelica	1	1
Apigenin	1	1
Ashwagandha	1	1
Baicalein	1	1
Caffeic acid phenethyl ester	1	1
Carnosic Acid	1	1
Carvacrol	1	1
Cinnamaldehyde	1	1
Deguelin	1	1
Diosgenin	1	1
Dogwood	1	1
Elecampane	1	1
Epicatechin	1	1
Eriodictyol	1	1
Fisetin	1	1
Formononetin	1	1
Ginger	1	1
Ginseng (Korean)	1	1
Hydroxytyrosol	1	1
Lactobacillus probiotics	1	1
Lotus	1	1
Lycopene	1	1
Medicinal Mushrooms	1	1
Nobiletin	1	1
Nordihydroguaiaretic acid (NDGA)	1	1
Oleuropein	1	1
Paeoniflorin	1	1
Paeonol	1	1
Phloretin	1	1
Piceatannol	1	1
Pterostilbene	1	1
Safflower	1	1
Saikosaponin	1	1
Salvia miltiorrhiza	1	1
Sesamol	1	1
Silibinin	1	1
Spirulina	1	1
Tetrahydrocurcumin	1	1
Urolithin A	1	1
Ursolic Acid	1	1
Verbascoside	1	1
Wogonin	1	1
acetyl-11-keto-beta-boswellic acid	1	1

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Pubmed Data : Front Cell Dev Biol. 2021 ;9:760022. Epub 2021 Dec 17. PMID: 34977014

Article Published Date : Dec 31, 2020

Study Type : Animal Study, In Vitro Study

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Substances : Tongkat Ali

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, Autophagy Inhibitors

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Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells.Oct 11, 2017

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Arctigenin might exert great therapeutic potential in immune-mediated liver injury.Dec 31, 2017

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Pubmed Data : Front Immunol. 2018 ;9:1881. Epub 2018 Aug 16. PMID: 30177931

Biochanin A sensitizes glioblastoma to temozolomide by inhibiting autophagy.Jan 31, 2022

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Pubmed Data : Mol Neurobiol. 2022 Feb ;59(2):1262-1272. Epub 2022 Jan 4. PMID: 34981417

Article Published Date : Jan 31, 2022

Study Type : Animal Study, In Vitro Study

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Substances : Biochanin A

Diseases : Glioblastoma

Pharmacological Actions : Autophagy Inhibitors, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Temozolomide

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Cardioprotective effect of stem-leaf saponins from Panax notoginseng on mice With sleep derivation.Dec 31, 2020

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Electroacupuncture ameliorates cerebral ischemia/reperfusion injury.Jul 02, 2020

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Pubmed Data : Aging (Albany NY). 2020 Jul 3 ;12(13):13187-13205. Epub 2020 Jul 3. PMID: 32620714

Article Published Date : Jul 02, 2020

Study Type : Animal Study

Additional Links

Diseases : Cerebral Ischemia

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Autophagy Inhibitors, Neuroprotective Agents

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Electroacupuncture inhibits neuronal autophagy and apoptosis via the PI3K/AKT Pathway following ischemic stroke.Dec 31, 2019

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Hesperidin alleviates hepatic injury caused by deoxynivalenol exposure.Jun 25, 2024

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Pubmed Data : J Agric Food Chem. 2024 Jun 26 ;72(25):14349-14363. Epub 2024 Jun 13. PMID: 38869217

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Puerarin protects cardiomyocytes from ischemia-reperfusion injury.May 07, 2021

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Pubmed Data : Cell Tissue Res. 2021 May 8. Epub 2021 May 8. PMID: 33963896

Article Published Date : May 07, 2021

Study Type : Animal Study

Additional Links

Substances : Puerarin

Diseases : Myocardial Ischemia

Pharmacological Actions : Autophagy Inhibitors, Cardioprotective

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Puerarin protects the brain against ischemia/reperfusion injury.May 31, 2018

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Pubmed Data : Biofactors. 2016 Jul 13. Epub 2016 Jul 13. PMID: 27412471

Article Published Date : Jul 12, 2016

Study Type : Animal Study

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Substances : Curcumin

Diseases : Kidney Damage: Chemically-Induced

Pharmacological Actions : Autophagy Inhibitors, Renoprotective

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Pubmed Data : Food Sci Nutr. 2022 Aug ;10(8):2773-2785. Epub 2022 Apr 19. PMID: 35959262

Article Published Date : Jul 31, 2022

Study Type : Animal Study

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Substances : Vitamin D

Diseases : Asthma, Lung Injury: Acute

Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors

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Vitexin could be regarded as a potent therapeutic agent for the treatment of liver cancer.Dec 19, 2016

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Pubmed Data : J Nat Med. 2020 Mar 23. Epub 2020 Mar 23. PMID: 32207025

Article Published Date : Mar 22, 2020

Study Type : In Vitro Study

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Substances : Arctigenin

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Autophagy Inhibitors

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AS-IV enhances the antitumor effects of propofol in NSCLC cells by inhibiting autophagy.Dec 31, 2022

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Pubmed Data : Sci Rep. 2024 Jun 25 ;14(1):14624. Epub 2024 Jun 25. PMID: 38918541

Article Published Date : Jun 24, 2024

Study Type : In Vitro Study

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Substances : Caffeic Acid

Diseases : Cancers: Drug Resistant, Colon Cancer

Pharmacological Actions : Antineoplastic Agents, Autophagy Inhibitors, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Oxaliplatin

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Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma.Nov 19, 2018

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Pubmed Data : J Neurooncol. 2018 Nov 20. Epub 2018 Nov 20. PMID: 30460630

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Pubmed Data : Front Pharmacol. 2020 ;11:126. Epub 2020 Feb 26. PMID: 32161548

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

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Substances : EGCG (Epigallocatechin gallate)

Diseases : Myocardial Infarction

Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors, Cardioprotective, MicroRNA modulator

Additional Keywords : Exosomes

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Fisetin induces apoptosis in colorectal cancer cells.Jul 13, 2023

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Pubmed Data : J Cell Biochem. 2023 Jul 14. Epub 2023 Jul 14. PMID: 37450699

Article Published Date : Jul 13, 2023

Study Type : In Vitro Study

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Substances : Fisetin

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, Autophagy Inhibitors

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Formononetin ameliorates the drug resistance of Taxol resistant triple negative breast cancer by inhibiting autophagy.Dec 31, 2020

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Pubmed Data : Am J Transl Res. 2021 ;13(2):497-514. Epub 2021 Feb 15. PMID: 33594306

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Pubmed Data : Am J Chin Med. 2021 ;49(8):1913-1927. Epub 2021 Nov 13. PMID: 34775933

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

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Substances : Ginsenosides

Diseases : Myocardial Ischemia

Pharmacological Actions : Anti-Apoptotic, Autophagy Inhibitors, Cardioprotective

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Hydroxysafflor yellow A (HSYA) alleviates apoptosis and autophagy of neural stem cells induced by heat stress.May 31, 2019

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Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Oct ;26(5):1425-1429. PMID: 30295262

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

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Substances : Luteolin

Diseases : Multiple Myeloma

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Inhibitors

Additional Keywords : Dose Response

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MA would be a beneficial nutritional therapy to ameliorate cigarette smoke induced lung injuryJan 14, 2013

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Pubmed Data : Food Chem. 2013 Jan 15 ;136(2):765-74. Epub 2012 Aug 16. PMID: 23122125

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Pubmed Data : Onco Targets Ther. 2017 ;10:453-461. Epub 2017 Jan 23. PMID: 28176967

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Parthenolide

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Inhibitors

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Phycocyanin exerts anti-pancreatic cancer activity by inducing apoptotic and autophagic cell death.Oct 02, 2016

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Pubmed Data : Biomed Pharmacother. 2019 Apr ;112:108599. Epub 2019 Feb 21. PMID: 30798134

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Pubmed Data : Front Oncol. 2019 ;9:942. Epub 2019 Sep 27. PMID: 31612107

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Glioblastoma

Pharmacological Actions : Apoptotic, Autophagy Inhibitors

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The results of this study suggest the role of neferine in preventing hypoxia induced autophagy in muscle cells.Sep 30, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Oct ;83:1407-1413. Epub 2016 Aug 29. PMID: 27583981

Article Published Date : Sep 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Hypoxia, Muscle Damage

Pharmacological Actions : Antioxidants, Autophagy Inhibitors, Cytoprotective, NF-E2-Related Factor-2 (Nrf2) Modulator

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View the Evidence: 184 Abstracts with Autophagy Inhibitors Research

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Effect of blueberry supplementation on a diet-induced rat model of prediabetes.Feb 12, 2024

Treatment with melittin induces apoptosis and autophagy of fibroblastlike synoviocytes in patients with rheumatoid arthritis.Dec 31, 2019

Capsaicin inhibits 5-FU-induced autophagy and rendering Cholangiocarcinoma cells more susceptible to 5-FU-induced apoptosis.Dec 31, 2014

Astragaloside IV targeting autophagy of T cells improves inflammation of asthma.Jan 10, 2024

Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting ROS-dependent autophagy in melanoma cancer cells.Dec 31, 2020

DHOK exerts anti-cancer effect through autophagy inhibition in colorectal cancer. Dec 31, 2020

Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells.Oct 11, 2017

Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy.Apr 28, 2024

Naringin inhibits cisplatin resistance of ovarian cancer cells.Jun 29, 2024

Panax notoginseng saponins inhibits oxidative stress- induced human nucleus pulposus cell apoptosis and delays disc degeneration.Sep 14, 2023

Resveratrol inhibits proliferation and induces autophagy by blocking SREBP1 expression in oral cancer cells.Nov 25, 2022

An antioxidant-rich extract of seaweed polyphenols combined with current PC treatment modalities may inhibit tumor relapse by targeting therapy-orchestrated autophagy in residual cells.Dec 31, 2014

Arctigenin might exert great therapeutic potential in immune-mediated liver injury.Dec 31, 2017

Ascorbic acid significantly decreased the cerebral damage, reduced oxidative stress and inhibited autophagy by reducing de novo synthesis of beclin 1.Oct 15, 2013

Astragaloside IV attenuates the myocardial injury caused by adriamycin by inhibiting autophagy.Dec 31, 2020

Astragaloside IV-targeting miRNA-1 attenuates lipopolysaccharide-induced cardiac dysfunction.Jun 14, 2021

Baicalin suppresses neuron autophagy and apoptosis by regulating astrocyte polarization in pentylenetetrazol-induced epileptic rats and PC12 cells.Dec 31, 2021

Betulinic acid ameliorates cerebral injury in middle cerebral artery occlusion.Jul 22, 2021

Biochanin A sensitizes glioblastoma to temozolomide by inhibiting autophagy.Jan 31, 2022

Cardioprotective effect of stem-leaf saponins from Panax notoginseng on mice With sleep derivation.Dec 31, 2020

Chlorogenic acid alleviates autophagy and insulin resistance by suppressing JNK pathway in a rat model of nonalcoholic fatty liver disease.May 31, 2018

Crocin has a paradoxical protective effect by regulating both the induction and inhibition of autophagy in ischemia and reperfusion injury.Apr 23, 2016

Dichloromethane extraction from Piper nigrum L. and P. longum L. to mitigate ischemic stroke.Aug 07, 2020

Effect and mechanism of asiatic acid on autophagy in myocardial ischemia-reperfusion injury in vivo and in vitro.Oct 31, 2020

Effect of electroacupuncture on relieving central post-stroke pain by inhibiting autophagy in the hippocampus.Jan 23, 2020

Effect of ginsenoside Rg1 in delaying premature ovarian failure induced by D-galactose.Nov 30, 2020

EGCG protects the mouse brain against cerebral ischemia/reperfusion injury.Dec 31, 2021

Electroacupuncture ameliorates cerebral ischemia/reperfusion injury.Jul 02, 2020

Electroacupuncture inhibits neuronal autophagy and apoptosis via the PI3K/AKT Pathway following ischemic stroke.Dec 31, 2019

Electroacupuncture pre-treatment is effective in improving cerebral ischemia-reperfusion injury in animals.Dec 24, 2019

Fucoidan alleviated autoimmune diabetes.Dec 31, 2023

Galangin improved non-alcoholic fatty liver Disease in mice by promoting autophagy.Dec 31, 2019

Galuteolin Inhibited Autophagy for neuroprotection against transient focal cerebral Ischemia.Jan 11, 2020

Ginsenoside CK may be a novel therapeutic potential for the treatment of neuroblastoma.Aug 31, 2019

Ginsenoside Rg1 alleviates learning and memory impairments and Aβ disposition.Dec 31, 2022

Ginsenoside Rg1 mitigates cerebral ischaemia/reperfusion injury.Jun 26, 2024

Glycyrrhizic acid improves tacrolimus-induced renal injury by regulating autophagy.Jan 31, 2023

Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy.Jan 24, 2018

Hesperidin alleviates hepatic injury caused by deoxynivalenol exposure.Jun 25, 2024

Hyperoside alleviates epilepsy-induced neuronal damage.Jul 14, 2020

Lactobacillus reuteri ZJ617 attenuates acute liver injury induced in mice by lipopolysaccharide.May 31, 2019

Malvidin protects against lipopolysaccharide-induced acute liver injury.Oct 14, 2022

Mangiferin enhances endochondral ossification-based bone repair in massive bone defect.Mar 15, 2018

Melatonin alleviates lipopolysaccharide-induced abnormal pregnancy.Jan 04, 2024

Melatonin or knockdown of CDK5 reduced MPTP-induced SNCA/α-synuclein aggregation in mice, which is widely thought to trigger the pathogenesis of PD.Aug 19, 2015

Melatonin reduces hypoxic-ischaemic induced autophagy and apoptosis.Mar 20, 2017

Moderate exercise prevents functional remodelling of the anterior pituitary gland in diet-induced insulin resistance in rats.Feb 29, 2016

Mulberry fruits extracts induce apoptosis and autophagy of liver cancer cell and prevent hepatocarcinogenesis in vivo.Dec 31, 2019

Naringenin attenuates non-alcoholic fatty liver disease.Dec 31, 2020

Neuroprotective effects of curcumin via autophagy induction in 6-hydroxydopamine Parkinson's models.Feb 01, 2022

Neuroprotective effects of pinocembrin on ischemia/reperfusion-induced brain injury by inhibiting autophagy.Sep 30, 2018

Oleanolic acid exhibits hepatoprotective effects via activation of PPARα and inhibition of apoptosis and autophagy.Dec 31, 2017

Panax notoginseng protects the rat brain function from traumatic brain injury.Apr 03, 2021

Polystyrene exacerbates cadmium-induced mitochondrial damage to lungJul 31, 2023

Puerarin prevents progression of experimental hypoxia-induced pulmonary hypertension via inhibition of autophagy.Sep 27, 2019

Puerarin protects cardiomyocytes from ischemia-reperfusion injury.May 07, 2021

Puerarin protects the brain against ischemia/reperfusion injury.May 31, 2018

Quercetin alleviates kidney damage caused by mercury chloride.Jul 19, 2024

Quercetin can inhibit cell viability and induce autophagy of U87 and U251 glioma cells in a dose-dependent manner. Oct 09, 2015

Resveratrol alleviates Kawasaki disease-induced myocardial injury via inhibition of apoptosis and autophagy.Oct 27, 2021

Rutin attenuates doxorubicin-induced cardiotoxicity.Jan 05, 2017

Rutin attenuates sorafenib-induced chemoresistance and autophagy in hepatocellular carcinoma.Dec 31, 2020

Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation.Jan 25, 2024

Shikonin attenuated hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy.Mar 20, 2017

Shikonin pre-treatment attenuates concanavalin A induced acute liver injury by inhibiting apoptosis and autophagy.Dec 31, 2015

Sinomenine ameliorates intervertebral disc degeneration.Dec 31, 2018

Sulforaphane ameliorates limb ischemia/reperfusion-induced muscular injury.Dec 31, 2021

Sulforaphane might emerge as a novel strategy to protect the bladder against ischemia-induced oxidative damage.Nov 07, 2016

Tanshinone IIA may exert neuroprotective effects via upregulating RACK1 and inhibiting autophagy in the hippocampus.Jan 31, 2017

The combination rutin with temozolomide may be a potentially useful therapeutic approach for glioblastoma multiforme patients.Mar 13, 2017

The nephroprotective effect exerted by curcumin in maleate-induced renal damage is associated with decreased mitochondrial fission and autophagy.Jul 12, 2016

The protection of luteolin against diabetic cardiomyopathy.Mar 19, 2023

Autophagy Inhibitors

View the Evidence:
184 Abstracts with Autophagy Inhibitors Research