Bax/Bcl2 ratio: Increase

Name	AC	CK
Curcumin	4	8
Piperine	1	5
Anthocyanins	1	2
Black Currant	1	2
Burdock	2	2
Cordyceps Militaris	2	2
Ellagic Acid	1	2
Ginkgo biloba	1	2
Pomegranate	1	2
Pomegranate Peel	2	2
Quercetin	2	2
Shiitake Mushroom	1	2
Astaxanthin	1	1
Cannabinoids: Synthetic	1	1
Cyanidin 3-glucoside	1	1
Epimedium	1	1
Flaxseed	1	1
Garlic	1	1
Genistein	1	1
Gingerol	1	1
Holy Basil	1	1
Huaier (Trametes robiniophila murr)	1	1
Loquat Leaves	1	1
Melatonin	1	1
Molasses	1	1
Oridonin	1	1
Phellinus Linteus	1	1
Polyphenols	1	1
Puerarin	1	1
Tocotrienol: Delta	1	1
Whey	1	1

[+]

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27888812

Article Published Date : Nov 20, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, NF-kappaB Inhibitor

Additional Keywords : Polysaccharides

[+]

Anthocyanin-rich black currant extract affords chemoprevention against chemically-induced liver cancer in rats.Jan 07, 2011

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2011 Jan 7. Epub 2011 Jan 7. PMID: 21216582

Article Published Date : Jan 07, 2011

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Black Currant

Diseases : Chemically-Induced Liver Damage, Liver Cancer

Pharmacological Actions : Bax/Bcl2 ratio: Increase, Chemopreventive

[+]

Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells via mitochondrial-mediated intrinsic pathway.Jan 19, 2017

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2017 Jan 20. Epub 2017 Jan 20. PMID: 28115284

Article Published Date : Jan 19, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase

Additional Keywords : Dose Response

[+]

Pomegranate fruit juice suppressed androgen dependent prostate carcinogenesis.Oct 03, 2014

Click here to read the entire abstract

Pubmed Data : Prostate. 2014 Oct 4. Epub 2014 Oct 4. PMID: 25284475

Article Published Date : Oct 03, 2014

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid, Pomegranate

Diseases : Cancer: Prostate, Prostate Cancer: Prevention

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, Chemopreventive

[+]

Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway.Jan 10, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cell Death Dis. 2018 01 11 ;9(1):15. Epub 2018 Jan 11. PMID: 29323103

Article Published Date : Jan 10, 2018

Study Type : In Vitro Study

Additional Links

Substances : Oridonin

Diseases : Osteosarcoma

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, NF-kappaB Inhibitor

[+]

"Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation."Jun 01, 2012

Click here to read the entire abstract

Pubmed Data : Mol Med Report. 2012 Jun ;5(6):1453-6. Epub 2012 Mar 22. PMID: 22447039

Article Published Date : Jun 01, 2012

Study Type : In Vitro Study

Additional Links

Substances : Quercetin

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase

[+]

6-Gingerol with 5-flourouracil and paclitaxel resulted in 83.2% and 52% inhibition of cervical cancer cells. Feb 26, 2017

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2017 Feb 27. Epub 2017 Feb 27. PMID: 28249781

Article Published Date : Feb 26, 2017

Study Type : In Vitro Study

Additional Links

Substances : Gingerol

Diseases : Cervical Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel

[+]

A homogeneous polysaccharide from Huaier inhibited the proliferation of human osteosarcoma cancer cells by promoting apoptosis.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2015 Jul ;36(7):5255-63. Epub 2015 Feb 11. PMID: 25666751

Article Published Date : Jun 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Huaier (Trametes robiniophila murr)

Diseases : Osteosarcoma

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation

Additional Keywords : Dose Response

[+]

An ethyl acetate extract of burdock may be a promising neuroprotective agent for the prevention and treatment of neurodegenerative diseases.Jun 30, 2014

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2014 Jul ;38(1):189-98. Epub 2014 Jun 7. PMID: 24956398

Article Published Date : Jun 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Burdock

Diseases : Oxidative Stress

Pharmacological Actions : Bax/Bcl2 ratio: Increase, Neuroprotective Agents, Superoxide Dismutase Up-regulation

Additional Keywords : Dose Response, Plant Extracts

[+]

Astaxanthin demonstrates anti-cancer activity against liver cancer.Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : Biol Pharm Bull. 2011;34(6):839-44. PMID: 21628881

Article Published Date : Jan 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Astaxanthin

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation

[+]

Burdock extracts may be regarded as potential antioxidant agents and possess potent neuroprotective activity against H2O2-induced injury.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : Cell Mol Neurobiol. 2015 Apr ;35(3):335-44. Epub 2014 Oct 29. PMID: 25352420

Article Published Date : Mar 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Burdock

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bax/Bcl2 ratio: Increase, Neuroprotective Agents

Additional Keywords : Plant Extracts

[+]

Cordycepin induces apoptosis in human bladder cancer T24 cells.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biosci Trends. 2019 ;13(4):324-333. PMID: 31527329

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Cordyceps Militaris

Diseases : Bladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase

[+]

Curcumin induces programmed cell death in hepatoma cells.Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : Asian Pac J Cancer Prev. 2011 ;12(8):1925-9. PMID: 22292626

Article Published Date : Jan 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Hepatoma

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase

[+]

Curcumin may be considered a novel therapeutic strategy to inhibit gastric cancer cell growth.Nov 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2016 Dec ;12(6):5156-5162. Epub 2016 Nov 4. PMID: 28105222

Article Published Date : Nov 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Bax/Bcl2 ratio: Increase, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Antiproliferative, CURCUMIN, gastric cancer

[+]

Curcumin nanoencapsulation with whey protein had enhanced colon cancer chemoprevention effects.Jul 08, 2016

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2016 Jul 9. Epub 2016 Jul 9. PMID: 27404761

Article Published Date : Jul 08, 2016

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Whey

Diseases : Colon Cancer

Pharmacological Actions : Bax/Bcl2 ratio: Increase, Chemopreventive, Tumor Suppressor Protein p53 Upregulation

[+]

Cyanidin-3-O-glucoside chloride exhibits cytotoxicity on Caco-2 cells in vitro and induces apoptosis in Caco-2 cells.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2016 ;17(7). Epub 2016 Jun 23. PMID: 27347927

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cyanidin 3-glucoside, Molasses

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Cyclin D1 Down-Regulation, Cytotoxic

[+]

Fresh garlic juice induces apoptosis in the KB cells through increasing caspase-3 activity and Bax:Bcl2 ratio.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Dent Res Dent Clin Dent Prospects. 2015 ;9(4):267-73. Epub 2015 Dec 30. PMID: 26889365

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Garlic

Diseases : Oral Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase

[+]

Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells.Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2013 ;41(6):1439-57. PMID: 24228611

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Phellinus Linteus, Polyphenols

Diseases : Leukemia

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Icariin and its derivatives are shown to be compounds with tremendous potential for the treatment of cancers.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2016 ;7:191. Epub 2016 Jun 29. PMID: 27445824

Article Published Date : Dec 31, 2015

Study Type : Review

Additional Links

Substances : Epimedium

Diseases : Cancers: All

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Immunomodulatory

[+]

Loquat leaves induce programmed cell death in human leukemia cell lines. Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : Chem Pharm Bull (Tokyo). 2011;59(3):378-81. PMID: 21372421

Article Published Date : Jan 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Loquat Leaves

Diseases : Leukemia

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-2 Activation

[+]

Melatonin might be a novel adjuvant therapy and may confer advantages for breast cancer treatment.Jul 14, 2016

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2016 Jul 15 ;83:456-465. Epub 2016 Jul 15. PMID: 27427852

Article Published Date : Jul 14, 2016

Study Type : In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Chemotherapeutic, P21 Activation

Problem Substances : Arsenic Trioxide

[+]

Ocimum sanctum essential oil has the ability to inhibit the proliferation of MCF-7 cells by inducing apoptosis.Apr 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacogn Mag. 2016 May ;12(Suppl 3):S327-31. PMID: 27563220

Article Published Date : Apr 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Holy Basil

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Essential Oils

[+]

Orbitides isolated from flaxseed induce apoptosis against SGC-7901 adenocarcinoma cells.Apr 11, 2020

Click here to read the entire abstract

Pubmed Data : Int J Food Sci Nutr. 2020 Apr 12:1-11. Epub 2020 Apr 12. PMID: 32281434

Article Published Date : Apr 11, 2020

Study Type : In Vitro Study

Additional Links

Substances : Flaxseed

Diseases : Gastric Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase

[+]

Physiological concentrations of genistein and 17β-estradiol inhibit breast cancer cell growth.Mar 31, 2012

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2012 Apr ;32(4):1181-91. PMID: 22493348

Article Published Date : Mar 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Genistein

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase

Additional Keywords : Paradox: Estrogen Kills Breast Cancer?

[+]

Pomegranate peel extract could be a promising drug candidate to treat prostate cancer.Jul 13, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Jul 14 ;93:976-984. Epub 2017 Jul 14. PMID: 28724216

Article Published Date : Jul 13, 2017

Study Type : In Vitro Study

Additional Links

Substances : Pomegranate Peel

Diseases : Prostate Cancer

Pharmacological Actions : Anti-metastatic, Bax/Bcl2 ratio: Increase

Additional Keywords : Plant Extracts

[+]

Pomegranate peel polyphenols could inhibit the growth of HepG2 cells by blocking the cell cycle and inducing the mitochondrial apoptotic pathway.Apr 23, 2016

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2016 Apr 24. Epub 2016 Apr 24. PMID: 27120393

Article Published Date : Apr 23, 2016

Study Type : In Vitro Study

Additional Links

Substances : Pomegranate Peel

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Dose Response, Plant Extracts

[+]

Puerarin inhibited cadmium induced apoptosis in rPT cells by ameliorating the mitochondrial dysfunction.Dec 24, 2016

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2016 Dec 25 ;260:219-231. Epub 2016 Oct 4. PMID: 27717697

Article Published Date : Dec 24, 2016

Study Type : In Vitro Study

Additional Links

Substances : Puerarin

Diseases : Cadmium Poisoning

Pharmacological Actions : Anti-Apoptotic, Bax/Bcl2 ratio: Increase

Additional Keywords : Anti-Apoptotic, Bax/Bcl2, Cadmium, Cadmium Poisoning, Puerarin

Problem Substances : Cadmium

[+]

Quercetin seems to be a promising approach for primary liver tumors through GLUT-1 competitive inhibition.Mar 03, 2016

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2016 Mar 4:1-17. Epub 2016 Mar 4. PMID: 26943884

Article Published Date : Mar 03, 2016

Study Type : In Vitro Study

Additional Links

Substances : Quercetin

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase

Additional Keywords : Chemothapeutic Synergy: Sorafenib

[+]

The inhibitory effect of cordycepin on the proliferation of MCF-7 breast cancer cells, and its mechanism.Aug 22, 2019

Click here to read the entire abstract

Pubmed Data : Biomolecules. 2019 Aug 23 ;9(9). Epub 2019 Aug 23. PMID: 31450828

Article Published Date : Aug 22, 2019

Study Type : In Vitro Study

Additional Links

Substances : Cordyceps Militaris

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase

[+]

This study demonstrated for the first time that δ-T3 is a potent agent against human bladder cancer cells.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(4):e0122712. Epub 2015 Apr 7. PMID: 25849286

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Tocotrienol: Delta

Diseases : Bladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Chemosensitizer, STAT3 Inhibitor

Additional Keywords : Chemotherapeutic Synergy: Gemcitabine

[+]

Thymoquinone and costunolide induce apoptosis of both proliferative and doxorubicin-induced-senescent colon and breast cancer cells.Dec 31, 2020

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Integr Cancer Ther. 2021 Jan-Dec;20:15347354211035450. PMID: 34490824

Article Published Date : Dec 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Thymoquinone

Diseases : Breast Cancer, Colon Cancer

Pharmacological Actions : Antiproliferative , Bax/Bcl2 ratio: Increase

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View the Evidence: 33 Abstracts with Bax/Bcl2 ratio: Increase Research

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Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

Anthocyanin-rich black currant extract affords chemoprevention against chemically-induced liver cancer in rats.Jan 07, 2011

Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells via mitochondrial-mediated intrinsic pathway.Jan 19, 2017

Pomegranate fruit juice suppressed androgen dependent prostate carcinogenesis.Oct 03, 2014

Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway.Jan 10, 2018

"Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation."Jun 01, 2012

6-Gingerol with 5-flourouracil and paclitaxel resulted in 83.2% and 52% inhibition of cervical cancer cells. Feb 26, 2017

A homogeneous polysaccharide from Huaier inhibited the proliferation of human osteosarcoma cancer cells by promoting apoptosis.Jun 30, 2015

An ethyl acetate extract of burdock may be a promising neuroprotective agent for the prevention and treatment of neurodegenerative diseases.Jun 30, 2014

Astaxanthin demonstrates anti-cancer activity against liver cancer.Jan 01, 2011

Burdock extracts may be regarded as potential antioxidant agents and possess potent neuroprotective activity against H2O2-induced injury.Mar 31, 2015

Cordycepin induces apoptosis in human bladder cancer T24 cells.Dec 31, 2018

Curcumin induces programmed cell death in hepatoma cells.Jan 01, 2011

Curcumin may be considered a novel therapeutic strategy to inhibit gastric cancer cell growth.Nov 30, 2016

Curcumin nanoencapsulation with whey protein had enhanced colon cancer chemoprevention effects.Jul 08, 2016

Cyanidin-3-O-glucoside chloride exhibits cytotoxicity on Caco-2 cells in vitro and induces apoptosis in Caco-2 cells.Dec 31, 2015

Fresh garlic juice induces apoptosis in the KB cells through increasing caspase-3 activity and Bax:Bcl2 ratio.Dec 31, 2014

Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells.Dec 31, 2012

Icariin and its derivatives are shown to be compounds with tremendous potential for the treatment of cancers.Dec 31, 2015

Loquat leaves induce programmed cell death in human leukemia cell lines. Jan 01, 2011

Melatonin might be a novel adjuvant therapy and may confer advantages for breast cancer treatment.Jul 14, 2016

Ocimum sanctum essential oil has the ability to inhibit the proliferation of MCF-7 cells by inducing apoptosis.Apr 30, 2016

Orbitides isolated from flaxseed induce apoptosis against SGC-7901 adenocarcinoma cells.Apr 11, 2020

Physiological concentrations of genistein and 17β-estradiol inhibit breast cancer cell growth.Mar 31, 2012

Pomegranate peel extract could be a promising drug candidate to treat prostate cancer.Jul 13, 2017

Pomegranate peel polyphenols could inhibit the growth of HepG2 cells by blocking the cell cycle and inducing the mitochondrial apoptotic pathway.Apr 23, 2016

Puerarin inhibited cadmium induced apoptosis in rPT cells by ameliorating the mitochondrial dysfunction.Dec 24, 2016

Quercetin seems to be a promising approach for primary liver tumors through GLUT-1 competitive inhibition.Mar 03, 2016

The inhibitory effect of cordycepin on the proliferation of MCF-7 breast cancer cells, and its mechanism.Aug 22, 2019

This study demonstrated for the first time that δ-T3 is a potent agent against human bladder cancer cells.Dec 31, 2014

Thymoquinone and costunolide induce apoptosis of both proliferative and doxorubicin-induced-senescent colon and breast cancer cells.Dec 31, 2020

WIN induces a clear apoptotic effect which was accompanied by up-regulation of the death signaling factors and down regulation of the survival factors.Mar 31, 2009

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Bax/Bcl2 ratio: Increase

View the Evidence:
33 Abstracts with Bax/Bcl2 ratio: Increase Research