Bax/Bcl2 ratio: Increase

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31 Substances Researched for Bax/Bcl2 ratio: Increase
NameACCKFocus
Curcumin48Locked
Piperine15Locked
Anthocyanins12Locked
Black Currant12Locked
Burdock22Locked
Cordyceps Militaris22Locked
Ellagic Acid12Locked
Ginkgo biloba12Locked
Pomegranate12Locked
Pomegranate Peel22Locked
Quercetin22Locked
Shiitake Mushroom 12Locked
Astaxanthin11Locked
Cannabinoids: Synthetic11Locked
Cyanidin 3-glucoside11Locked
Epimedium11Locked
Flaxseed11Locked
Garlic11Locked
Genistein11Locked
Gingerol 11Locked
Holy Basil11Locked
Huaier (Trametes robiniophila murr)11Locked
Loquat Leaves11Locked
Melatonin11Locked
Molasses11Locked
Oridonin11Locked
Phellinus Linteus11Locked
Polyphenols11Locked
Puerarin11Locked
Tocotrienol: Delta11Locked
Whey11Locked

View the Evidence:
37 Abstracts with Bax/Bcl2 ratio: Increase Research

[+]

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Pubmed Data : Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID: 24272201
Article Published Date : Mar 31, 2014
Study Type : Human In Vitro
Additional Links
Substances : Piperine
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Selective Cytotoxicity
[+]

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27888812
Article Published Date : Nov 20, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, NF-kappaB Inhibitor
Additional Keywords : Polysaccharides
[+]

Anthocyanin-rich black currant extract affords chemoprevention against chemically-induced liver cancer in rats.Jan 07, 2011

Pubmed Data : J Nutr Biochem. 2011 Jan 7. Epub 2011 Jan 7. PMID: 21216582
Article Published Date : Jan 07, 2011
Study Type : Animal Study
Additional Links
Substances : Anthocyanins, Black Currant
Diseases : Chemically-Induced Liver Damage, Liver Cancer
Pharmacological Actions : Bax/Bcl2 ratio: Increase, Chemopreventive
[+]

Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells via mitochondrial-mediated intrinsic pathway.Jan 19, 2017

Pubmed Data : J Ethnopharmacol. 2017 Jan 20. Epub 2017 Jan 20. PMID: 28115284
Article Published Date : Jan 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase
Additional Keywords : Dose Response
[+]

Lipophilic grape seed proanthocyanidin exerts anti-cervical cancer effects.Feb 18, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Feb 19 ;11(2). Epub 2022 Feb 19. PMID: 35204304
Article Published Date : Feb 18, 2022
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest
[+]

Pomegranate fruit juice suppressed androgen dependent prostate carcinogenesis.Oct 03, 2014

Pubmed Data : Prostate. 2014 Oct 4. Epub 2014 Oct 4. PMID: 25284475
Article Published Date : Oct 03, 2014
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Pomegranate
Diseases : Cancer: Prostate, Prostate Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, Chemopreventive
[+]

Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway.Jan 10, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2018 01 11 ;9(1):15. Epub 2018 Jan 11. PMID: 29323103
Article Published Date : Jan 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, NF-kappaB Inhibitor
[+]

"Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation."Jun 01, 2012

Pubmed Data : Mol Med Report. 2012 Jun ;5(6):1453-6. Epub 2012 Mar 22. PMID: 22447039
Article Published Date : Jun 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase
[+]

6-Gingerol with 5-flourouracil and paclitaxel resulted in 83.2% and 52% inhibition of cervical cancer cells. Feb 26, 2017

Pubmed Data : Food Chem Toxicol. 2017 Feb 27. Epub 2017 Feb 27. PMID: 28249781
Article Published Date : Feb 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel
[+]

A homogeneous polysaccharide from Huaier inhibited the proliferation of human osteosarcoma cancer cells by promoting apoptosis.Jun 30, 2015

Pubmed Data : Tumour Biol. 2015 Jul ;36(7):5255-63. Epub 2015 Feb 11. PMID: 25666751
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Huaier (Trametes robiniophila murr)
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation
Additional Keywords : Dose Response
[+]

An ethyl acetate extract of burdock may be a promising neuroprotective agent for the prevention and treatment of neurodegenerative diseases.Jun 30, 2014

Pubmed Data : Environ Toxicol Pharmacol. 2014 Jul ;38(1):189-98. Epub 2014 Jun 7. PMID: 24956398
Article Published Date : Jun 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Oxidative Stress
Pharmacological Actions : Bax/Bcl2 ratio: Increase, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Additional Keywords : Dose Response, Plant Extracts
[+]

Astaxanthin demonstrates anti-cancer activity against liver cancer.Jan 01, 2011

Pubmed Data : Biol Pharm Bull. 2011;34(6):839-44. PMID: 21628881
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation
[+]

Burdock extracts may be regarded as potential antioxidant agents and possess potent neuroprotective activity against H2O2-induced injury.Mar 31, 2015

Pubmed Data : Cell Mol Neurobiol. 2015 Apr ;35(3):335-44. Epub 2014 Oct 29. PMID: 25352420
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Burdock
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bax/Bcl2 ratio: Increase, Neuroprotective Agents
Additional Keywords : Plant Extracts
[+]

Cordycepin induces apoptosis in human bladder cancer T24 cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Trends. 2019 ;13(4):324-333. PMID: 31527329
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Cordyceps Militaris
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase
[+]

Curcumin induces programmed cell death in hepatoma cells.Jan 01, 2011

Pubmed Data : Asian Pac J Cancer Prev. 2011 ;12(8):1925-9. PMID: 22292626
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Hepatoma
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase
[+]

Curcumin may be considered a novel therapeutic strategy to inhibit gastric cancer cell growth.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Dec ;12(6):5156-5162. Epub 2016 Nov 4. PMID: 28105222
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Bax/Bcl2 ratio: Increase, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Antiproliferative, CURCUMIN, gastric cancer
[+]

Curcumin nanoencapsulation with whey protein had enhanced colon cancer chemoprevention effects.Jul 08, 2016

Pubmed Data : Eur J Pharmacol. 2016 Jul 9. Epub 2016 Jul 9. PMID: 27404761
Article Published Date : Jul 08, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Whey
Diseases : Colon Cancer
Pharmacological Actions : Bax/Bcl2 ratio: Increase, Chemopreventive, Tumor Suppressor Protein p53 Upregulation
[+]

Cyanidin-3-O-glucoside chloride exhibits cytotoxicity on Caco-2 cells in vitro and induces apoptosis in Caco-2 cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(7). Epub 2016 Jun 23. PMID: 27347927
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cyanidin 3-glucoside, Molasses
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Cyclin D1 Down-Regulation, Cytotoxic
[+]

Echinacoside exerts anti-tumor activity via the miR-503-3p/TGF-β1/Smad aixs in liver cancer.Jun 09, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2021 Jun 10 ;21(1):304. Epub 2021 Jun 10. PMID: 34112163
Article Published Date : Jun 09, 2021
Study Type : In Vitro Study
Additional Links
Substances : Echinacea
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Transforming growth factor beta (TGF-β) upregulation
[+]

Fresh garlic juice induces apoptosis in the KB cells through increasing caspase-3 activity and Bax:Bcl2 ratio.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Dent Res Dent Clin Dent Prospects. 2015 ;9(4):267-73. Epub 2015 Dec 30. PMID: 26889365
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Garlic
Diseases : Oral Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase
[+]

Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells.Dec 31, 2012

Pubmed Data : Am J Chin Med. 2013 ;41(6):1439-57. PMID: 24228611
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus, Polyphenols
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Icariin and its derivatives are shown to be compounds with tremendous potential for the treatment of cancers.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:191. Epub 2016 Jun 29. PMID: 27445824
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Epimedium
Diseases : Cancers: All
Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Immunomodulatory
[+]

Isothiocyanate From Moringa oleifera seeds inhibits the growth and migration of renal cancer cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Cell Dev Biol. 2021 ;9:790618. Epub 2022 Jan 4. PMID: 35059399
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanate, Moringa oleifera
Diseases : Kidney Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Bax/Bcl2 ratio: Increase
[+]

Loquat leaves induce programmed cell death in human leukemia cell lines. Jan 01, 2011

Pubmed Data : Chem Pharm Bull (Tokyo). 2011;59(3):378-81. PMID: 21372421
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Loquat Leaves
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-2 Activation
[+]

Melatonin might be a novel adjuvant therapy and may confer advantages for breast cancer treatment.Jul 14, 2016

Pubmed Data : Biomed Pharmacother. 2016 Jul 15 ;83:456-465. Epub 2016 Jul 15. PMID: 27427852
Article Published Date : Jul 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Chemotherapeutic, P21 Activation
Problem Substances : Arsenic Trioxide
[+]

Ocimum sanctum essential oil has the ability to inhibit the proliferation of MCF-7 cells by inducing apoptosis.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2016 May ;12(Suppl 3):S327-31. PMID: 27563220
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Holy Basil
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Essential Oils
[+]

Orbitides isolated from flaxseed induce apoptosis against SGC-7901 adenocarcinoma cells.Apr 11, 2020

Pubmed Data : Int J Food Sci Nutr. 2020 Apr 12:1-11. Epub 2020 Apr 12. PMID: 32281434
Article Published Date : Apr 11, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flaxseed
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase
[+]

Physiological concentrations of genistein and 17β-estradiol inhibit breast cancer cell growth.Mar 31, 2012

Pubmed Data : Anticancer Res. 2012 Apr ;32(4):1181-91. PMID: 22493348
Article Published Date : Mar 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase
Additional Keywords : Paradox: Estrogen Kills Breast Cancer?
[+]

Pomegranate peel extract could be a promising drug candidate to treat prostate cancer.Jul 13, 2017

Pubmed Data : Biomed Pharmacother. 2017 Jul 14 ;93:976-984. Epub 2017 Jul 14. PMID: 28724216
Article Published Date : Jul 13, 2017
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate Peel
Diseases : Prostate Cancer
Pharmacological Actions : Anti-metastatic, Bax/Bcl2 ratio: Increase
Additional Keywords : Plant Extracts
[+]

Pomegranate peel polyphenols could inhibit the growth of HepG2 cells by blocking the cell cycle and inducing the mitochondrial apoptotic pathway.Apr 23, 2016

Pubmed Data : Food Chem Toxicol. 2016 Apr 24. Epub 2016 Apr 24. PMID: 27120393
Article Published Date : Apr 23, 2016
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate Peel
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Dose Response, Plant Extracts
[+]

Puerarin inhibited cadmium induced apoptosis in rPT cells by ameliorating the mitochondrial dysfunction.Dec 24, 2016

Pubmed Data : Chem Biol Interact. 2016 Dec 25 ;260:219-231. Epub 2016 Oct 4. PMID: 27717697
Article Published Date : Dec 24, 2016
Study Type : In Vitro Study
Additional Links
Substances : Puerarin
Diseases : Cadmium Poisoning
Pharmacological Actions : Anti-Apoptotic, Bax/Bcl2 ratio: Increase
Additional Keywords : Anti-Apoptotic, Bax/Bcl2, Cadmium, Cadmium Poisoning, Puerarin
Problem Substances : Cadmium
[+]

Quercetin seems to be a promising approach for primary liver tumors through GLUT-1 competitive inhibition.Mar 03, 2016

Pubmed Data : Nutr Cancer. 2016 Mar 4:1-17. Epub 2016 Mar 4. PMID: 26943884
Article Published Date : Mar 03, 2016
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase
Additional Keywords : Chemothapeutic Synergy: Sorafenib
[+]

The inhibitory effect of cordycepin on the proliferation of MCF-7 breast cancer cells, and its mechanism.Aug 22, 2019

Pubmed Data : Biomolecules. 2019 Aug 23 ;9(9). Epub 2019 Aug 23. PMID: 31450828
Article Published Date : Aug 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Cordyceps Militaris
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase
[+]

This study demonstrated for the first time that δ-T3 is a potent agent against human bladder cancer cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(4):e0122712. Epub 2015 Apr 7. PMID: 25849286
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Tocotrienol: Delta
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Chemosensitizer, STAT3 Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Thymoquinone and costunolide induce apoptosis of both proliferative and doxorubicin-induced-senescent colon and breast cancer cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2021 Jan-Dec;20:15347354211035450. PMID: 34490824
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Breast Cancer, Colon Cancer
Pharmacological Actions : Antiproliferative , Bax/Bcl2 ratio: Increase
[+]

WIN induces a clear apoptotic effect which was accompanied by up-regulation of the death signaling factors and down regulation of the survival factors.Mar 31, 2009

Pubmed Data : Biochimie. 2009 Apr ;91(4):457-65. Epub 2008 Nov 27. PMID: 19059457
Article Published Date : Mar 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Cannabinoids: Synthetic
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, Survivin Down-Regulation
[+]

Zerumbone sensitizes the anti-cancer efficacy of cisplatin in hepatocellular carcinoma cells.Mar 23, 2022

Pubmed Data : Anticancer Agents Med Chem. 2022 Mar 24. Epub 2022 Mar 24. PMID: 35331096
Article Published Date : Mar 23, 2022
Study Type : In Vitro Study
Additional Links
Substances : Zerumbone
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest
Additional Keywords : Chemotherapeutic Synergy: Cisplatin

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