Bcl-2 protein down-regulation

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223 Substances Researched for Bcl-2 protein down-regulation
NameACCKFocus
Curcumin1619Locked
Ginsenosides1214Locked
Thymoquinone814Locked
Oridonin1111Locked
Cucurbitacin B 510Locked
Melatonin710Locked
Piperine210Locked
Parthenolide59Locked
Formononetin58Locked
Kahweol48Locked
Tanshinone IIA78Locked
Apigenin37Locked
Beta-Elemene77Locked
Flavonoids57Locked
Ginger57Locked
Paeoniflorin67Locked
Resveratrol57Locked
Fermented Foods and Beverages26Locked
Fucoidan66Locked
Neem26Locked
Pterostilbene46Locked
Brown Rice15Locked
Chaga Mushroom (Inonotus obliquus)15Locked
Curcumin: Degradiation byproducts15Locked
Feverfew15Locked
Homeopathic Medicine: All45Locked
Mangosteen15Locked
Pumpkin15Locked
Reishi Mushroom35Locked
Tetrahydrocurcumin15Locked
Turmeric45Locked
Verbascoside15Locked
Astaxanthin34Locked
Baicalein24Locked
Bee Venom24Locked
Berberine44Locked
Blueberry24Locked
Carnosic Acid34Locked
Catechin 34Locked
Crocin44Locked
Huaier (Trametes robiniophila murr)44Locked
Isoliquiritigenin34Locked
Ligustrazine24Locked
Lotus 44Locked
Modified Arabinoxylan Rice Bran (MGN-3)24Locked
Moringa oleifera34Locked
Myricetin44Locked
Paeonol44Locked
Phloretin34Locked
Polyphenols34Locked
Quercetin34Locked
Safflower34Locked
Sulforaphane44Locked
Amygdalin23Locked
Asiatic Acid23Locked
Betulinic acid33Locked
Chrysin23Locked
D-Limonene33Locked
Deguelin23Locked
Ellagic Acid23Locked
Frankincense23Locked
Ginkgo biloba33Locked
Ginseng (Korean)23Locked
Grape Seed Extract23Locked
Indole-3-Carbinol23Locked
Lichens23Locked
Phellinus Linteus23Locked
Piceatannol 33Locked
Prunella vulgaris23Locked
Rosemaric Acid23Locked
Shikonin33Locked
Silibinin33Locked
Tomato23Locked
Toona sinensis 23Locked
Vitamin C33Locked
Zerumbone33Locked
Angelica12Locked
Arugula12Locked
Bai Zhu12Locked
Bee Propolis22Locked
Berbamine12Locked
Biochanin A22Locked
Bromelain22Locked
Buckwheat12Locked
Bufalin22Locked
Caffeine12Locked
Cinnamon12Locked
Cordyceps Militaris22Locked
Curcumol12Locked
Daisy12Locked
Demethoxycurcumin22Locked
Diosgenin12Locked
Diosmin 12Locked
EGCG (Epigallocatechin gallate)22Locked
Emodin12Locked
Fisetin12Locked
Fucoxanthin 12Locked
Gallic Acid22Locked
Garlic12Locked
Gold (nanoparticles)22Locked
Grape12Locked
Helenalin22Locked
Holy Basil22Locked
Honokiol12Locked
Hydrogen Water12Locked
Isothiocyanates22Locked
Japanese mugwort22Locked
Kefir22Locked
Lactobacillus rhamnosus GG12Locked
Lactoferrin22Locked
Licorice22Locked
Long Pepper12Locked
Lupeol12Locked
Luteolin22Locked
Lycopene22Locked
Magnolol22Locked
Mistletoe12Locked
Mulberry22Locked
Pea12Locked
Pine Bark Extract22Locked
Pomegranate12Locked
Probiotics12Locked
Rhubarb22Locked
Schisandra12Locked
Sesamol12Locked
Shiitake Mushroom 12Locked
Soursop22Locked
Star Fruit12Locked
Stilbenes12Locked
Strawberry12Locked
Tocotrienol: Gamma12Locked
Vanillin12Locked
Vitamin E12Locked
Vitamin K12Locked
Vitexins12Locked
Wogonin22Locked
2-Methoxyestradiol11Locked
6-Shogaol11Locked
Amygdalin (laetrile)11Locked
Arnica11Locked
Artemisinin11Locked
Babchi11Locked
Benzyl isothiocyanate 11Locked
Beta-sesquiphellandrene11Locked
Bisdemethoxycurcumin11Locked
Bitter Melon11Locked
Cafestol11Locked
Caffeic acid phenethyl ester11Locked
Cannabinoids: Synthetic11Locked
Capsaicin11Locked
Carrot11Locked
Celastrol11Locked
Celery seed11Locked
Chickpea11Locked
Chlorella (Algae)11Locked
Chrysanthemum Indicum11Locked
Clinacanthus nutans11Locked
Cordyceps sinensis11Locked
Cryptomeria japonica11Locked
Curry Tree11Locked
Cyanidin 3-glucoside11Locked
Diosmetin11Locked
Eucalyptus11Locked
Eugenol11Locked
Evodiamine11Locked
Fennel11Locked
Flax Straw11Locked
Galbanic Acid11Locked
Gallotannins11Locked
Genistein11Locked
Gingerol 11Locked
Graviola 11Locked
Guggul11Locked
Gymnema Sylvestre11Locked
Harmine11Locked
Hesperidin11Locked
Honeysuckle11Locked
Hyperforin11Locked
Isoflavones11Locked
Kaempferol11Locked
Lemongrass11Locked
Liquiritigenin11Locked
Litchi11Locked
Lithospermum erythrorhizon11Locked
Lutein11Locked
Maitake Mushroom11Locked
Mangiferin11Locked
Mango Seed11Locked
Mushrooms: All 11Locked
Nettle11Locked
Nexrutine (Phellodendrom)11Locked
Nigella sativa (aka Black Seed)11Locked
Nobiletin 11Locked
Oleanolic acid11Locked
Oleocanthal11Locked
Olive Oil11Locked
Orthosiphon11Locked
Peony11Locked
Persimmon 11Locked
Phyllanthus emblica11Locked
Piperlongumine 11Locked
Polyunsaturated Fatty Acids (PUFAs)11Locked
Psychedelics:All 11Locked
Puerarin11Locked
Rosemary11Locked
Selenium11Locked
Silver (nanoparticles)11Locked
Spirulina11Locked
Sweet Potato11Locked
Syrian rue11Locked
Tea11Locked
Tea: Oolong11Locked
Terminalia chebula11Locked
Tetrahydropalmatine 11Locked
Thistle11Locked
Thymol11Locked
Turmerones11Locked
Ursolic Acid11Locked
Venom: Toad11Locked
Vitamin E: Gamma-tocotrienol11Locked
Vitamin E: alpha tocopherol11Locked
White Mulberry 11Locked
Xanthohumol11Locked

View the Evidence:
501 Abstracts with Bcl-2 protein down-regulation Research

[+]

Berberine suppressed the progression of human glioma cells.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2022 Jan-Dec;21:15347354221130303. PMID: 36255058
Article Published Date : Dec 31, 2021
Study Type : Human In Vitro
Additional Links
Substances : Berberine
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Transforming growth factor beta (TGF-β) inhibitor
[+]

Chaga mushroom extract can inhibit the proliferation of tumor cells.Dec 31, 2013

Pubmed Data : Int J Med Mushrooms. 2014 ;16(1):29-36. PMID: 24940902
Article Published Date : Dec 31, 2013
Study Type : Human In Vitro
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus)
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Plant Extracts
[+]

Cucurmosin has potential anticancer activity for human hepatoma.Dec 31, 2011

Pubmed Data : Mol Med Rep. 2012 Jan ;5(1):196-201. Epub 2011 Sep 30. PMID: 21964700
Article Published Date : Dec 31, 2011
Study Type : Human In Vitro
Additional Links
Substances : Pumpkin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Fermented brown rice extract causes apoptotic death of human acute lymphoblastic leukemia cells.Jan 13, 2016

Pubmed Data : Appl Biochem Biotechnol. 2016 Jan 14. Epub 2016 Jan 14. PMID: 26769704
Article Published Date : Jan 13, 2016
Study Type : Human In Vitro
Additional Links
Substances : Brown Rice, Fermented Foods and Beverages
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Human NB SH-SY5Y cells undergo apoptosis in response to treatment with cucurbitacin B.Jun 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2014 Jul ;10(1):89-94. Epub 2014 Apr 24. PMID: 24789581
Article Published Date : Jun 30, 2014
Study Type : Human In Vitro
Additional Links
Substances : Cucurbitacin B
Diseases : Neuroblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Kahweol inhibits colorectal tumor cell growth by promoting apoptosis and suppressing HSP70 expression.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 Mar ;23(2):128-33. Epub 2015 Mar 1. PMID: 25767680
Article Published Date : Feb 28, 2015
Study Type : Human In Vitro
Additional Links
Substances : Kahweol
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Heat Shock Protein Down-Regulation
[+]

Neem leaf extract exhibits anti-leukemic properties in patient primary chronic lymphocytic leukemia cells.Feb 28, 2014

Pubmed Data : Leuk Lymphoma. 2014 Mar ;55(3):652-61. Epub 2013 Jul 1. PMID: 23721511
Article Published Date : Feb 28, 2014
Study Type : Human In Vitro
Additional Links
Substances : Neem
Diseases : Leukemia: Chronic Lymphocytic Leukemia (CLL)
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Dose Response, Plant Extracts
[+]

Parthenolide is a potential novel therapeutic agent for aggressive colorectal cancer treatment.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Intest Res. 2017 Apr ;15(2):174-181. Epub 2017 Apr 27. PMID: 28522946
Article Published Date : Mar 31, 2017
Study Type : Human In Vitro
Additional Links
Substances : Feverfew, Parthenolide
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Piperine enhanced mitomycin-C therapy in human cervical cancer cells.Nov 19, 2017

Pubmed Data : Biomed Pharmacother. 2017 Nov 20. Epub 2017 Nov 20. PMID: 29169726
Article Published Date : Nov 19, 2017
Study Type : Human In Vitro
Additional Links
Substances : Piperine
Diseases : Cervical Cancer
Pharmacological Actions : Bcl-2 protein down-regulation, Chemosensitizer
Additional Keywords : Natural Substance/Drug Synergy
[+]

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Pubmed Data : Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID: 24272201
Article Published Date : Mar 31, 2014
Study Type : Human In Vitro
Additional Links
Substances : Piperine
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Selective Cytotoxicity
[+]

Protective effects of acteoside against X‑ray‑induced damage in human skin fibroblasts.Jul 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Aug ;12(2):2301-6. Epub 2015 Apr 16. PMID: 25892089
Article Published Date : Jul 31, 2015
Study Type : Human In Vitro
Additional Links
Substances : Verbascoside
Diseases : Chemotherapy and Radiation Toxicity
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Radioprotective
[+]

Tetrahydrocurcumin exhibited significant cell growth inhibition by inducing MCF-7 cells to undergo mitochondrial apoptosis and G2/M arrest.Apr 30, 2014

Pubmed Data : Food Chem Toxicol. 2014 May ;67:193-200. Epub 2014 Mar 1. PMID: 24593988
Article Published Date : Apr 30, 2014
Study Type : Human In Vitro
Additional Links
Substances : Curcumin: Degradiation byproducts, Tetrahydrocurcumin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Cell cycle arrest, P21 Activation
[+]

The present study results indicated that human bladder cancer T-24 cells are highly sensitive to growth inhibition by apigenin.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2015 ;15:33. Epub 2015 Mar 29. PMID: 25859163
Article Published Date : Dec 31, 2014
Study Type : Human In Vitro
Additional Links
Substances : Apigenin
Diseases : Bladder Cancer, Bladder Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, P21 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Dose Response
[+]

Thymoquinone promotes pancreatic cancer cell death and reduction of tumor size.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Prev Med. 2016 ;2016:1407840. Epub 2016 Dec 26. PMID: 28105374
Article Published Date : Dec 31, 2015
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Thymoquinone
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Histone deacetylase inhibitor, P21 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Dose Response
[+]

α-mangostin may be used as food supplement or a potential therapeutic compound for breast cancer.Feb 17, 2016

Pubmed Data : Int J Oncol. 2016 Feb 18. Epub 2016 Feb 18. PMID: 26892433
Article Published Date : Feb 17, 2016
Study Type : Human In Vitro
Additional Links
Substances : Mangosteen
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Acteoside promotes autophagy and apoptosis of hepatoma cells.Apr 30, 2023

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2023 May ;48(9):2343-2351. PMID: 37282863
Article Published Date : Apr 30, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Verbascoside
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Bcl-2 protein down-regulation
[+]

Emodin reverses 5-Fu resistance in human colorectal cancer via downregulation of PI3K/Akt signaling pathway.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2020 ;12(5):1851-1861. Epub 2020 May 15. PMID: 32509181
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Emodin
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer
[+]

Pea lectin inhibits growth of Ehrlich ascites carcinoma cells by inducing apoptosis and G2/M cell cycle arrest in vivo.Nov 14, 2013

Pubmed Data : Phytomedicine. 2013 Nov 15 ;20(14):1288-96. Epub 2013 Jul 16. PMID: 23867650
Article Published Date : Nov 14, 2013
Study Type : Animal Study
Additional Links
Substances : Pea
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

(-)-Epigallocatechin-3-gallate modulates spinal cord neuronal degeneration by enhancing growth-associated protein 43, B-cell lymphoma 2, and decreasing B-cell lymphoma 2-associated x protein expression after sciatic nerve crush injury.Feb 01, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Neurotrauma. 2015 Feb 1 ;32(3):170-84. Epub 2014 Nov 10. PMID: 25025489
Article Published Date : Feb 01, 2015
Study Type : Animal Study
Additional Links
Substances : Catechin
Pharmacological Actions : Bcl-2 protein down-regulation, Neuroprotective Agents, Regenerative
Additional Keywords : Nerve Regeneration
[+]

A saponin fraction of Korean red ginseng exhibited in vitro and in vivo antitumor activity in C6 glioma glioma cells.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2017 Jul ;41(3):386-391. Epub 2017 Jan 5. PMID: 28701882
Article Published Date : Jun 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Acacetin alleviates myocardial ischaemia/reperfusion injury.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2022 Dec ;60(1):553-561. PMID: 35244510
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Myocardial Ischemia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Bcl-2 protein down-regulation, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Amygdalin may offer a new therapeutic option for patients with cervical cancer.Jan 31, 2013

Pubmed Data : Immunopharmacol Immunotoxicol. 2013 Feb ;35(1):43-51. PMID: 23137229
Article Published Date : Jan 31, 2013
Study Type : Animal Study
Additional Links
Substances : Amygdalin
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

An extract of Fragaria ananassa had a protective effect against cadmium chloride toxicity upon the liver. Jan 21, 2017

Pubmed Data : Toxicol Mech Methods. 2017 Jan 22:1-27. Epub 2017 Jan 22. PMID: 28110594
Article Published Date : Jan 21, 2017
Study Type : Animal Study
Additional Links
Substances : Strawberry
Diseases : Cadmium Poisoning
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Cadmium
[+]

Annona muricata peel extract inhibits carbohydrate metabolizing enzymes and reduces pancreatic β-cells, inflammation, and apoptosis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2022 ;17(10):e0276984. Epub 2022 Oct 27. PMID: 36301972
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Soursop
Diseases : Diabetic Complications
Pharmacological Actions : Alpha-glucosidase inhibitor , Anti-Apoptotic, Bcl-2 protein down-regulation, Hypoglycemic Agents
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
[+]

Anti-breast cancer activity of resveratrol encapsulated in liposomes.Nov 19, 2019

Pubmed Data : J Mater Chem B. 2019 Nov 20. Epub 2019 Nov 20. PMID: 31746932
Article Published Date : Nov 19, 2019
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Anti-inflammatory and apoptotic signalling effect of fucoxanthin on benzo(A)pyrene-induced lung cancer.Dec 31, 2018

Pubmed Data : J Environ Pathol Toxicol Oncol. 2019 ;38(3):239-251. PMID: 31679311
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemopreventive
Problem Substances : Benzo(a)pyrene
[+]

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer.Jan 10, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2016 11 ;9(11):1084-1088. Epub 2016 Oct 22. PMID: 27890369
Article Published Date : Jan 10, 2016
Study Type : Animal Study
Additional Links
Substances : Tanshinone IIA
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemotherapeutic
Additional Keywords : Natural Substance/Drug Synergy
[+]

Antiproliferative activity and apoptotic efficiency of Syzygium cumini bark methanolic extract against EAC cells.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Agents Med Chem. 2021 ;21(6):782-792. PMID: 32781964
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Jambul
Diseases : Breast Cancer
Pharmacological Actions : Antioxidants, Apoptotic, Bcl-2 protein down-regulation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Plant Extracts
[+]

Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma-bearing mice.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419869489. PMID: 31462112
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom
Diseases : Cervical Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors
Additional Keywords : Polysaccharides
[+]

Arabinoxylan rice bran (MGN-3/Biobran) enhances radiotherapy in animals bearing Ehrlich ascites carcinoma.Aug 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Radiat Res. 2019 Aug 29. Epub 2019 Aug 29. PMID: 31504707
Article Published Date : Aug 28, 2019
Study Type : Animal Study
Additional Links
Substances : Modified Arabinoxylan Rice Bran (MGN-3)
Diseases : Ehrlich carcinoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Radiosensitizer
[+]

Asiatic acid could be used as an effective chemopreventive agent against 1,2-dimethylhydrazine induced colon carcinogenesis.Dec 24, 2017

Pubmed Data : Chem Biol Interact. 2017 Dec 25 ;278:197-211. Epub 2017 Nov 6. PMID: 29108773
Article Published Date : Dec 24, 2017
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemopreventive
[+]

Astragaloside IV ameliorates cerebral ischemia-reperfusion injury.Oct 11, 2022

Pubmed Data : Neuroreport. 2022 Oct 12 ;33(15):656-662. Epub 2022 Sep 7. PMID: 36126263
Article Published Date : Oct 11, 2022
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Brain Ischemia
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents
[+]

Baicalein could increase caspase-3 and Bax expression and decrease survivin and Bcl-2 to induce apoptosis.Aug 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pancreas. 2017 Sep ;46(8):1076-1081. PMID: 28787336
Article Published Date : Aug 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Survivin Down-Regulation
[+]

Bee venom suppressed the development of benign prostatic hyperplasia.Nov 30, 2015

Pubmed Data : Exp Biol Med (Maywood). 2015 Dec ;240(12):1656-63. Epub 2015 Jun 17. PMID: 26085572
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Bee Venom
Diseases : Prostatic Hyperplasia: Benign
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Berbamine suppresses cell viability and induces apoptosis in colorectal cancer.Jan 31, 2018

Pubmed Data : Cytotechnology. 2018 Feb ;70(1):321-329. Epub 2017 Sep 30. PMID: 28965196
Article Published Date : Jan 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berbamine
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Beta-elemene can inhibit the growth of rabbit VX2 laryngeal tumors.Aug 06, 2016

Pubmed Data : Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Aug 7 ;51(8):606-10. PMID: 27625131
Article Published Date : Aug 06, 2016
Study Type : Animal Study
Additional Links
Diseases : Laryngeal Diseases
Pharmacological Actions : Antineoplastic Agents, Bcl-2 protein down-regulation, Vascular Endothelial Growth Factor D Inhibitor
[+]

Biobran provides protection against chemical induction of glandular stomach carcinogenesis in rats.May 03, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2016 May 4. Epub 2016 May 4. PMID: 27151588
Article Published Date : May 03, 2016
Study Type : Animal Study
Additional Links
Substances : Modified Arabinoxylan Rice Bran (MGN-3)
Diseases : Gastric Cancer, Gastric Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Chemopreventive
[+]

Blueberry and probiotics prevents NASH progression.Feb 26, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Feb 27 ;9(3). Epub 2017 Feb 27. PMID: 28264426
Article Published Date : Feb 26, 2017
Study Type : Animal Study
Additional Links
Substances : Blueberry, Probiotics
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Blueberry can induce HSC-T6 apoptosis by down-regulating Bcl-2 expression and decreasing the ratio of Bcl-2/Bax.Aug 17, 2015

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2015 Aug 18 ;95(31):2560-4. PMID: 26711393
Article Published Date : Aug 17, 2015
Study Type : Animal Study
Additional Links
Substances : Blueberry
Diseases : Liver Cancer
Pharmacological Actions : Bax/Bcl2 Ratio: Decrease, Bcl-2 protein down-regulation
Additional Keywords : Plant Extracts
[+]

Both free and encapsulated sesamol demonstrated inhibition of tumor progression by inducing skin cell apoptosis via bcl-2/bax mediated pathway.Aug 18, 2016

Pubmed Data : Anticancer Agents Med Chem. 2016 Aug 19. Epub 2016 Aug 19. PMID: 27539478
Article Published Date : Aug 18, 2016
Study Type : Animal Study
Additional Links
Substances : Sesamol
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Chemopreventive
[+]

Caffeine exhibits radioprotective properties in whole-body irradiated male mice.Mar 01, 2003

Pubmed Data : In Vivo. 2003 Mar-Apr;17(2):197-200. PMID: 12792986
Article Published Date : Mar 01, 2003
Study Type : Animal Study
Additional Links
Substances : Caffeine
Diseases : Radiation Induced Illness
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Radioprotective, Tumor Suppressor Protein p53 Upregulation
[+]

Carnosic acid cooperates with tamoxifen to induce apoptosis in breast cancer cells.Apr 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 May ;89:827-837. Epub 2017 Mar 6. PMID: 28282784
Article Published Date : Apr 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer, Carnosic Acid, Synergy with Tamoxifen
Problem Substances : Tamoxifen
[+]

Components of star fruit have potential benefit on treating learning and memory deficit in APP/PS1 transgenic Alzheimer's disease mice.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2018 ;49(3):1064-1073. Epub 2018 Sep 7. PMID: 30196278
Article Published Date : Dec 31, 2017
Study Type : Transgenic Animal Study
Additional Links
Substances : Star Fruit
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents
[+]

Cucurbitacin B and cisplatin combination treatment may be a potentially useful therapeutic option for individuals diagnosed with laryngeal cancer.Aug 31, 2010

Pubmed Data : Eur J Pharmacol. 2010 Sep 1 ;641(1):15-22. Epub 2010 May 17. PMID: 20483353
Article Published Date : Aug 31, 2010
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Laryngeal Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Cuminaldehyde induced apoptosis and also suppressed tumor cells growth and the associated biomarkers.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2016 ;7(3):251-61. Epub 2016 Jan 5. PMID: 26918037
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cinnamon
Diseases : Lung Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Topoisomerase I inhibitor, Topoisomerase II Inhibitor
[+]

Curcumin combined with 5-FU led to the lower cell viability and higher apoptosis than 5-FU treated alone.Sep 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2012 Oct ;44(10):847-55. PMID: 23017833
Article Published Date : Sep 30, 2012
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Curcumin exhibits anti-melanoma activity. Mar 01, 2003

Pubmed Data : Phytother Res. 2003 Mar;17(3):217-21. PMID: 19260281
Article Published Date : Mar 01, 2003
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumin has anti-apoptotic properties in a transgenic amyotrophic lateral sclerosis mice.May 31, 2005

Pubmed Data : J Neurochem. 2005 Jun ;93(5):1087-98. PMID: 15934930
Article Published Date : May 31, 2005
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, NF-kappaB Inhibitor
[+]

Curcumol could suppress the growth of human colorectal cancer xenografts in vivo.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2015 ;16(8):19851-67. Epub 2015 Aug 20. PMID: 26307972
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Cytoprotective effect of genistein against dexamethasone-induced pancreatic β-cell apoptosis.Jul 27, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2022 Jul 28 ;12(1):12950. Epub 2022 Jul 28. PMID: 35902739
Article Published Date : Jul 27, 2022
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Inflammation
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Cytoprotective, NF-kappaB Inhibitor, Pancreato Protective Agents
Problem Substances : Dexamethasone
[+]

Deguelin might be a potential therapeutic agent for treatment of colorectal cancer.Oct 31, 2012

Pubmed Data : Dig Dis Sci. 2012 Nov ;57(11):2873-82. Epub 2012 May 24. PMID: 22623043
Article Published Date : Oct 31, 2012
Study Type : Animal Study
Additional Links
Substances : Deguelin
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Interleukin-8 downregulation, NF-kappaB Inhibitor
[+]

Diallyl trisulfide regulates cell apoptosis and invasion in human osteosarcoma U2OS cells.Nov 30, 2020

Pubmed Data : Histol Histopathol. 2020 Dec ;35(12):1511-1520. Epub 2020 Dec 29. PMID: 33372687
Article Published Date : Nov 30, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Organosulfur Compounds
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Diallyl trisulfide significantly inhibited tumor growth and promoted tumor apoptosis in a xenograft model of gastric cancer cell SGC-7901.May 10, 2017

Pubmed Data : Int Immunopharmacol. 2017 May 11 ;48:135-145. Epub 2017 May 11. PMID: 28501767
Article Published Date : May 10, 2017
Study Type : Animal Study
Additional Links
Substances : Garlic
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemotherapeutic, Interleukin-12 upregulation
[+]

Dieckol, isolated from the edible brown algae Ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor growth.Jan 31, 2015

Pubmed Data : J Cancer Res Clin Oncol. 2015 Feb ;141(2):255-68. Epub 2014 Sep 13. PMID: 25216701
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Substances : Phlorotannins, Seaweed: Brown
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Dietary turmeric led to a decrease in DMBA-induced tumor burden and multiplicity in animals. Oct 31, 2008

Pubmed Data : Toxicol Appl Pharmacol. 2008 Nov 1 ;232(3):428-39. Epub 2008 Jul 19. PMID: 18687351
Article Published Date : Oct 31, 2008
Study Type : Animal Study
Additional Links
Substances : Turmeric
Diseases : Oral Cancer, Oral Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

Diosmin protects against cerebral ischemia/reperfusion injury.May 29, 2014

Pubmed Data : Neuroscience. 2014 May 30 ;268:318-27. Epub 2014 Mar 26. PMID: 24680937
Article Published Date : May 29, 2014
Study Type : Animal Study
Additional Links
Substances : Diosmin
Diseases : Brain Ischemia
Pharmacological Actions : Bcl-2 protein down-regulation, Neuroprotective Agents
[+]

Effect of astaxanthin on neuron damage, inflammatory factors expressions and oxidative stress in mice with subarachnoid hemorrhage.Dec 31, 2020

Pubmed Data : Am J Transl Res. 2021 ;13(11):13043-13050. Epub 2021 Nov 15. PMID: 34956522
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Subarachnoid hemorrhage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Bcl-2 protein down-regulation, Interleukin-17 downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Effect of electroacupuncture on myocardial inflammatory injury and apoptosis in mice with acute myocardial ischemia.Nov 11, 2022

Pubmed Data : Zhongguo Zhen Jiu. 2022 Nov 12 ;42(11):1269-77. PMID: 36397225
Article Published Date : Nov 11, 2022
Study Type : Animal Study
Additional Links
Diseases : Myocardial Ischemia
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Bcl-2 protein down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor C Inhibitor
[+]

Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in H22 tumor-bearing mice.Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2019 Nov ;23(6):501-508. Epub 2019 Oct 24. PMID: 31680772
Article Published Date : Oct 31, 2019
Study Type : Animal Study
Additional Links
Substances : Rosemaric Acid
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Interleukin-10 downregulation, Interleukin-6 Downregulation
[+]

Ellagic acid may be beneficial for the treatment of glioblastoma.Jan 31, 2017

Pubmed Data : Oncol Rep. 2017 Feb ;37(2):1084-1092. Epub 2016 Dec 22. PMID: 28035411
Article Published Date : Jan 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ellagic Acid
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Enhanced anticancer effect and reduced toxicity of doxorubicin in combination with thymoquinone.Sep 06, 2017

Pubmed Data : Eur J Pharm Sci. 2017 Sep 7 ;109:525-532. Epub 2017 Sep 7. PMID: 28890201
Article Published Date : Sep 06, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Bcl-2 protein down-regulation, Chemoprotective Agents, Chemotherapeuticm, Tumor Suppressor Protein p53 Upregulation
[+]

Eruca sativa seed extract may be considered a promising natural product against breast cancer.Dec 31, 2014

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(18):8411-8. PMID: 26745094
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Arugula
Diseases : Breast Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemopreventive, NF-kappaB Inhibitor
[+]

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine.Apr 14, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cancer Res. 2012 Apr 15 ;18(8):2220-9. Epub 2012 Feb 20. PMID: 22351692
Article Published Date : Apr 14, 2012
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Gamma, Vitamin E
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Bcl-2 protein down-regulation, Chemosensitizer, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Formononetin has inhibitory effects on the proliferation of U2SO cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2015 ;37(3):933-9. Epub 2015 Sep 18. PMID: 26381132
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Dose Response
[+]

Formononetin mediates neuroprotection against cerebral ischemia/reperfusion.Sep 14, 2014

Pubmed Data : J Neurol Sci. 2014 Sep 15 ;344(1-2):100-4. Epub 2014 Jun 22. PMID: 24996490
Article Published Date : Sep 14, 2014
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents
[+]

Frankincense essential oil suppresses melanoma cancer through down regulation of Bcl-2/Bax cascade signaling and ameliorates heptotoxicity.May 27, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2019 May 28 ;10(37):3472-3490. Epub 2019 May 28. PMID: 31191820
Article Published Date : May 27, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Frankincense
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Melanoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Hepatoprotective
Additional Keywords : Essential Oils
Problem Substances : Acetaminophen
[+]

Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo.Dec 04, 2014

Pubmed Data : Chem Biol Interact. 2014 Dec 5 ;224:149-56. Epub 2014 Nov 4. PMID: 25450235
Article Published Date : Dec 04, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Squamous cell carcinoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cell cycle arrest
[+]

Ganoderma lucidum triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas.Dec 31, 2016

Pubmed Data : Mutat Res. 2017 Jan ;813:45-51. Epub 2016 Dec 2. PMID: 28010928
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom
Diseases : Breast Cancer, Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Chemopreventive, Cyclin D1 Down-Regulation
Additional Keywords : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer, Chemopreventive, Cyclin D1 Down-Regulation, Reishi Mushroom, skin cancer
[+]

Ginger has significant anti-breast cancer properties.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Biotechnol. 2012 ;2012:614356. Epub 2012 Aug 26. PMID: 22969274
Article Published Date : Dec 31, 2011
Study Type : Insect Study
Additional Links
Substances : Ginger
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 Ratio: Decrease, Bcl-2 protein down-regulation
[+]

Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion injury.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Jun ;11(6):4518-24. Epub 2015 Feb 11. PMID: 25672441
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Bcl-2 protein down-regulation, Cardioprotective, Superoxide Dismutase Up-regulation
[+]

Ginsenoside Rg3 promotes cytotoxicity and apoptosis of Paclitaxel by inhibiting NF-κB signalling.Feb 19, 2017

Pubmed Data : Biomed Pharmacother. 2017 Feb 20 ;89:227-232. Epub 2017 Feb 20. PMID: 28231544
Article Published Date : Feb 19, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Bcl-2 protein down-regulation, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Grape juice is able to modulate rat colon carcinogenesis as a result of induction of apoptosis.Jan 31, 2015

Pubmed Data : Toxicol Mech Methods. 2015 Feb ;25(2):91-7. Epub 2015 Jan 22. PMID: 25421551
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Substances : Grape
Diseases : Colon Cancer, Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Phytotherapy
[+]

Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(8):e43064. Epub 2012 Aug 8. PMID: 22905202
Article Published Date : Dec 31, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Grape Seed Extract
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Plant Extracts, Proanthocyanidins
[+]

Hesperidin attenuates oxidative stress, inflammation, apoptosis, and cardiac dysfunction in sodium fluoride-induced cardiotoxicity.Jul 31, 2022

Pubmed Data : Cardiovasc Toxicol. 2022 Aug ;22(8):727-735. Epub 2022 May 23. PMID: 35606666
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Fluoride Toxicity , Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Tumor Suppressor Protein p53 Upregulation
Problem Substances : Sodium Fluoride
[+]

Hispolon may have the potential to serve as a therapeutic tool to treat acute myeloid leukemia.Oct 22, 2013

Pubmed Data : J Agric Food Chem. 2013 Oct 23 ;61(42):10063-73. Epub 2013 Oct 15. PMID: 24093560
Article Published Date : Oct 22, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phellinus Linteus
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Honokiol effectively inhibit the proliferation of rat edometeriotic tissues in a dose dependent manner.Dec 31, 2015

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2016 ;62(1):1-5. Epub 2016 Jan 11. PMID: 26828978
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Endometriosis
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Survivin Down-Regulation
Additional Keywords : Dose Response
[+]

Hydrogen-rich water exerting a protective effect on ovarian reserve function.Jan 04, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Chin Med J (Engl). 2016 10 5 ;129(19):2331-7. PMID: 27647193
Article Published Date : Jan 04, 2016
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Ovarian Failure
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation
[+]

Induction of apoptosis of tumor cells by some potentiated homeopathic drugs.May 31, 2012

Pubmed Data : Integr Cancer Ther. 2012 Jun ;11(2):172-82. Epub 2011 Jul 19. PMID: 21771822
Article Published Date : May 31, 2012
Study Type : Animal Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Lymphoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Phytotherapy
[+]

Isoliquiritigenin attenuates neuroinflammation in traumatic brain injury.Dec 31, 2018

Pubmed Data : Neuroimmunomodulation. 2019 ;26(2):102-110. Epub 2019 Feb 15. PMID: 30783039
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Neuroprotective Agents
[+]

Lactobacillus rhamnosus GG supplementation improves the mucosal barrier function in the intestine of weaned piglets challenged by porcine rotavirus.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(1):e0146312. Epub 2016 Jan 4. PMID: 26727003
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus GG
Diseases : Diarrhea
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Interleukin-4 downregulation
[+]

Lupeol enhances inhibitory effect of 5-fluorouracil on human gastric carcinoma cells.Apr 30, 2016

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2016 May ;389(5):477-84. Epub 2016 Feb 19. PMID: 26892272
Article Published Date : Apr 30, 2016
Study Type : Animal Study
Additional Links
Substances : Lupeol
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Survivin Down-Regulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

M. oleifera extract could be an effective therapeutic supplement for treatment of melamine-induced hepato-renal damage.Aug 25, 2020

Pubmed Data : Gene. 2020 Aug 26:145083. Epub 2020 Aug 26. PMID: 32860902
Article Published Date : Aug 25, 2020
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Kidney Damage, Liver Damage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Bcl-2 protein down-regulation, Hepatoprotective, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melatonin has ameliorative properties in an animal mode of experimental colitis. Nov 01, 2006

Pubmed Data : J Pineal Res. 2006 Nov;41(4):363-73. PMID: 17014694
Article Published Date : Nov 01, 2006
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Colitis
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melatonin inhibits oxidative stress and programmed cell death in fetal brains of hyperhomocysteinemic rat dams.Oct 01, 2007

Pubmed Data : J Pineal Res. 2007 Oct;43(3):225-31. PMID: 17803518
Article Published Date : Oct 01, 2007
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : High Homocysteine, Lipid Peroxidation, Oxidative Stress, Prenatal Nutrition: Prevention of Problems
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents, Tumor Suppressor Protein p53 Upregulation
[+]

Melatonin reduces age-related oxidaitve stress in the brain of age-accelerated mice.Jan 01, 2009

Pubmed Data : J Pineal Res. 2009 Jan;46(1):106-14. PMID: 19090913
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Aging: Brain , Oxidative Stress
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Melittin efficiently reduced paraquat-induced lung injuries.Apr 15, 2019

Pubmed Data : Molecules. 2019 Apr 16 ;24(8). Epub 2019 Apr 16. PMID: 30995821
Article Published Date : Apr 15, 2019
Study Type : Animal Study
Additional Links
Substances : Bee Venom
Diseases : Oxidative Stress, Pesticide Toxicity
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Problem Substances : Paraquat
[+]

Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury.Jul 10, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2022 Jul 11 ;13(7):594. Epub 2022 Jul 11. PMID: 35821123
Article Published Date : Jul 10, 2022
Study Type : Animal Study
Additional Links
Substances : Proanthocyanidins
Diseases : Ischemia
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Prophylactic Agents
[+]

Neuroprotection by paeoniflorin in the MPTP mouse model of Parkinson's disease.Dec 31, 2016

Pubmed Data : Neuropharmacology. 2017 04 ;116:412-420. Epub 2017 Jan 16. PMID: 28093210
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Parkinson's Disease
Pharmacological Actions : Bcl-2 protein down-regulation, Neuroprotective Agents
[+]

Neuroprotective effect of ginsenoside Re on drosophila model of Parkinson's disease.Mar 31, 2023

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2023 Apr ;48(7):1927-1935. PMID: 37282969
Article Published Date : Mar 31, 2023
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Antioxidants, Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
[+]

Nobiletin ameliorates streptozotocin-cadmium-induced diabetic nephropathy via NF-κB signalling pathway.Aug 03, 2021

Pubmed Data : Arch Physiol Biochem. 2021 Aug 4:1-9. Epub 2021 Aug 4. PMID: 34346259
Article Published Date : Aug 03, 2021
Study Type : Animal Study
Additional Links
Substances : Nobiletin
Diseases : Diabetic Nephropathy, Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Renoprotective
Problem Substances : Cadmium
[+]

Omega-3 rich oils attenuate ADHD-like behaviour induced by dietary monosodium glutamate.Dec 31, 2020

Pubmed Data : Pak J Biol Sci. 2021 Jan ;24(8):868-880. PMID: 34486354
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Fenugreek, Omega-3 Fatty Acids, Walnut
Diseases : Attention Deficit Hyperactivity Disorder
Pharmacological Actions : Bcl-2 protein down-regulation, Neuroprotective Agents
Problem Substances : Monosodium Glutamate (MSG)
[+]

Phloretin is able to inhibit NSCLC A549 cell growth by inducing apoptosis.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2015 Dec ;34(6):2871-9. PMID: 26503828
Article Published Date : Nov 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Phloretin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Piperlongumine suppresses growth and sensitizes pancreatic tumors to gemcitabine in a xenograft mouse model.Dec 13, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 Dec 14. Epub 2015 Dec 14. PMID: 26667450
Article Published Date : Dec 13, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Long Pepper
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Chemosensitizer, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Survivin Down-Regulation, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Pomegranate hull extract has antitumorigenic effect and could be a candidate for anticancer drugs.Jul 05, 2016

Pubmed Data : Nutr Cancer. 2016 Jul 6:1-8. Epub 2016 Jul 6. PMID: 27383944
Article Published Date : Jul 05, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation
Additional Keywords : Plant Extracts
[+]

Pomegranate juice and punicalagin-mediated chemoprevention of hepatocellular carcinogenesis.Nov 01, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2022 Nov 2 ;22(1):333. Epub 2022 Nov 2. PMID: 36324170
Article Published Date : Nov 01, 2022
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Punicalagin
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Chemopreventive, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Pre-treatment with astaxanthin has a protective effect and is a safe therapeutic treatment for ischemia-reperfusion injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(11):e0187810. Epub 2017 Nov 9. PMID: 29121675
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Hypoxia, Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Protective effect of ginsenoside Rd on military aviation noise-induced cochlear hair cell damage.Nov 03, 2022

Pubmed Data : Environ Sci Pollut Res Int. 2022 Nov 4. Epub 2022 Nov 4. PMID: 36331733
Article Published Date : Nov 03, 2022
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Hearing Loss: Noise-Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Malondialdehyde Down-regulation, SIRT1 Activator, Superoxide Dismutase Up-regulation
[+]

Protective role of crocin against sepsis-induced injury in the liver, kidney and lungs.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2022 Dec ;60(1):543-552. PMID: 35225146
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Sepsis
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Hepatoprotective, NF-kappaB Inhibitor, Renoprotective
[+]

Pterostilbene and quercetin inhibits metastatic melanoma growth and extends host survival.Jan 01, 2005

Pubmed Data : Neoplasia. 2005 Jan;7(1):37-47. PMID: 15736313
Article Published Date : Jan 01, 2005
Study Type : Animal Study
Additional Links
Substances : Pterostilbene, Quercetin
Diseases : Cancer Metastasis, Melanoma
Pharmacological Actions : Bcl-2 protein down-regulation, Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords : Stilbenes
[+]

Pterostilbene is a potent anti-cancer against human esophageal cancer cells in vitro and in vivo.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2016 ;38(3):1226-44. Epub 2016 Mar 17. PMID: 26982591
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Dose Response
[+]

Punicalagin protects against the development of methotrexate-induced hepatotoxicity.Oct 14, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2022 Oct 15 ;23(20). Epub 2022 Oct 15. PMID: 36293191
Article Published Date : Oct 14, 2022
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Drug Toxicity: Methotrexate, Inflammation, Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Hepatoprotective, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Safety: resveratrol has a positive effect on early embryonic development of porcine embryos.Jun 01, 2010

Pubmed Data : J Reprod Dev. 2010 Jun;56(3):330-5. Epub 2010 Feb 18. PMID: 20168050
Article Published Date : Jun 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Prenatal Herb Exposure, Prenatal Nutrition
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Enzyme Inhibitors
[+]

Safflower polysaccharide inhibits the development of tongue squamous cell carcinoma.Aug 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Surg Oncol. 2018 Aug 13 ;16(1):167. Epub 2018 Aug 13. PMID: 30103745
Article Published Date : Aug 12, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Safflower
Diseases : Squamous cell carcinoma, Tongue Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors
Additional Keywords : Polysaccharides
[+]

Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2019 Jul ;140(3):248-254. Epub 2019 Jul 24. PMID: 31400930
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Schisandra
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Antioxidants, Bcl-2 protein down-regulation, Hepatoprotective, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
[+]

Spica prunellae extract has certain in vivo anti-tumour effect, which may be achieved through regulation of apoptosis related proteins.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Afr J Tradit Complement Altern Med. 2013 ;10(5):318-24. Epub 2013 Aug 12. PMID: 24311843
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Prunella vulgaris
Diseases : Acute T cell Leukemias
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma.Jan 31, 2010

Pubmed Data : Cancer Chemother Pharmacol. 2010 Feb ;65(3):481-9. Epub 2009 Jul 8. PMID: 19585117
Article Published Date : Jan 31, 2010
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Tatariside possess notable antitumor effects against HCC and might play a favorable role in drug combination therapy against tumors with protective effect on liver.Jul 14, 2015

Pubmed Data : Phytomedicine. 2015 Jul 15 ;22(7-8):730-6. Epub 2015 May 23. PMID: 26141759
Article Published Date : Jul 14, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Buckwheat
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemoprotective Agents, Tumor Suppressor Protein p53 Upregulation
Problem Substances : Cyclophosphamide
[+]

Tetramethylpyrazine alleviates neural apoptosis in injured spinal cord.Sep 30, 2017

Pubmed Data : Biomed Pharmacother. 2017 Oct ;94:827-833. Epub 2017 Aug 10. PMID: 28802236
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, MicroRNA modulator, Neuroprotective Agents
[+]

Tetramethylpyrazine attenuates carbon tetrachloride-caused liver injury and fibrogenesis.Jan 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Feb ;86:521-530. Epub 2016 Dec 23. PMID: 28024287
Article Published Date : Jan 31, 2017
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Chemically-Induced Liver Damage, Liver Cirrhosis
Pharmacological Actions : Anti-Angiogenic, Anti-Apoptotic, Bcl-2 protein down-regulation, Vascular Endothelial Growth Factor A Inhibitor
[+]

The inhibitory role of stigmasterol on tumor growth by inducing apoptosis in Balb/c mouse with spontaneous breast tumor.Jan 19, 2022

Pubmed Data : BMC Pharmacol Toxicol. 2022 06 20 ;23(1):42. Epub 2022 Jun 20. PMID: 35725497
Article Published Date : Jan 19, 2022
Study Type : Animal Study
Additional Links
Substances : Stigmasterol
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

The synergistic anti cancer effects of paclitaxel and α-tomatine may be beneficial for refractory prostate cancer treatment.Nov 14, 2013

Pubmed Data : Phytomedicine. 2013 Nov 15 ;20(14):1297-305. Epub 2013 Aug 4. PMID: 23920276
Article Published Date : Nov 14, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Tomato
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, PI3K-AKT inhibitor
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Plant Extracts, Significant Treatment Outcome
[+]

These findings demonstrate that formononetin exerted the hair regrowth effect on hair loss.Dec 31, 2015

Pubmed Data : Planta Med. 2016 Jan ;82(1-2):65-9. Epub 2016 Jan 12. PMID: 26756818
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Hair Loss
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Hair Regeneration
[+]

These results demonstrated that atractylenolide I has significant antitumor activity in lung carcinoma cells.Oct 28, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2013 Oct 29 ;18(11):13357-68. Epub 2013 Oct 29. PMID: 24172243
Article Published Date : Oct 28, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bai Zhu
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

These results demonstrated that indole-3-carbinol could induce apoptosis of hepatic stellate cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 ;41(4):1481-1490. Epub 2017 Mar 24. PMID: 28395284
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Liver Fibrosis
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

These results indicate that baicalein may be a potential drug for gastric cancer therapy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer. 2016 ;7(4):453-61. Epub 2016 Jan 29. PMID: 26918059
Article Published Date : Dec 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation
Additional Keywords : Dose Response
[+]

These results indicated that diosgenin was effective in inhibiting testosterone propionate-induced prostate enlargement.Nov 30, 2016

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2016 Dec ;36(6):806-810. Epub 2016 Dec 7. PMID: 27924509
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Diosgenin
Diseases : Oxidative Stress, Prostatic Hyperplasia: Benign
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

These results provide powerful evidence for the chemopreventive efficacy of Chrysin against chemically induced renal carcinogenesis.Jul 08, 2016

Pubmed Data : Arch Biochem Biophys. 2016 Jul 9. Epub 2016 Jul 9. PMID: 27403965
Article Published Date : Jul 08, 2016
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Kidney Cancer, Kidney Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Apoptotic, Bcl-2 protein down-regulation, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results reveal the capability of TPHE to induce apoptosis in LA7-induced tumours in rats.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2015 ;36(3):988-1003. Epub 2015 Jun 15. PMID: 26087920
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Daisy
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemopreventive
Additional Keywords : Selective Antiproliferation
[+]

These results suggest that the combination viscumTT may have a potential therapeutic value for the treatment AML.Dec 31, 2014

Pubmed Data : PLoS One. 2015;10(8):e0133892. Epub 2015 Aug 5. PMID: 26244918
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Mistletoe
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-8 activation, Caspase-9 Activation
Additional Keywords : Dose Response, Plant Extracts
[+]

This data shows the antitumor potential of the Angelica archangelica extract against breast cancer cells.Feb 28, 2019

Pubmed Data : J Integr Med. 2019 Mar ;17(2):132-140. Epub 2019 Feb 8. PMID: 30799248
Article Published Date : Feb 28, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Angelica
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

This is the first insight into the antitumor, anti-proliferative and the induction of apoptosis efficacy of fisetin against ovarian cancer.Oct 31, 2016

Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Nov ;47(6):830-836. PMID: 28598107
Article Published Date : Oct 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Dose Response
[+]

Thymoquinone loaded in nanostructured lipid carrier showed enhanced anticancer activity.Dec 31, 2017

Pubmed Data : Nanomedicine (Lond). 2018 07 ;13(13):1567-1582. PMID: 30028248
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Triterpenoids of Ganoderma lucidum inhibited S180 sarcoma and H22 hepatoma.May 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2023 Jun ;9(6):e16682. Epub 2023 Jun 7. PMID: 37484292
Article Published Date : May 31, 2023
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom
Diseases : Cancers: All, Liver Cancer
Pharmacological Actions : Antioxidants, Bcl-2 protein down-regulation, Gastrointestinal Agents
[+]

Vanillin can be a potential lead molecule for the development of non-toxic agents for the treatment of breast cancer either alone or combined with DOX.Aug 31, 2016

Pubmed Data : Pathol Res Pract. 2016 Sep ;212(9):767-77. Epub 2016 Jun 22. PMID: 27493101
Article Published Date : Aug 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vanillin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Vitamin K enhances sorafenib-mediated liver cancer cell growth inhibition in vitro and in vivo.Dec 14, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Cancer. 2010 Dec 15 ;127(12):2949-58. PMID: 21351273
Article Published Date : Dec 14, 2010
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vitamin K
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Chemothapeutic Synergy: Sorafenib
[+]

Vitexin displays preclinical antitumor activity by suppressing NF-κB signaling in nasopharyngeal carcinoma.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2019 ;12:4461-4468. Epub 2019 Jun 5. PMID: 31239714
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Vitexins
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Bcl-2 protein down-regulation, NF-kappaB Inhibitor
[+]

Zingerone exhibits antihyperlipidemic and antiapoptotic potential on alcohol induced hepatotoxicity.Jun 24, 2017

Pubmed Data : Chem Biol Interact. 2017 Jun 25 ;272:197-206. Epub 2017 Apr 22. PMID: 28442378
Article Published Date : Jun 24, 2017
Study Type : Animal Study
Additional Links
Substances : Ginger, Polyphenols
Diseases : Alcohol Toxicity , Alcoholic Liver Disease, DNA damage
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Hepatoprotective, Hypolipidemic
[+]

β-glucans from Lentinus edodes inhibited angiogenesis by suppressing VEGF expression, leading to slow progression of tumors.Jun 28, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Jun 29 ;6:28802. Epub 2016 Jun 29. PMID: 27353254
Article Published Date : Jun 28, 2016
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Animal Cancers, Tumors
Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Bcl-2 protein down-regulation
[+]

A novel combination of oridonin and valproic acid in enhancement of apoptosis induction of HL-60 leukemia cells.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2016 Feb ;48(2):734-46. Epub 2015 Dec 15. PMID: 26676928
Article Published Date : Jan 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Leukemia, Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis.Jul 23, 2020

Pubmed Data : J Cell Physiol. 2020 Jul 24. Epub 2020 Jul 24. PMID: 32710479
Article Published Date : Jul 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Lutein
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Oridonin enhances the radiosensitivity of lung cancer cells by upregulating Bax and downregulating Bcl-2.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Dec ;16(6):4859-4864. Epub 2018 Sep 27. PMID: 30546402
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Lung Cancer
Pharmacological Actions : Bcl-2 protein down-regulation, Radiosensitizer
[+]

Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway.Jan 10, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2018 01 11 ;9(1):15. Epub 2018 Jan 11. PMID: 29323103
Article Published Date : Jan 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, NF-kappaB Inhibitor
[+]

Oridonin increases anticancer effects of lentinan in HepG2 human hepatoblastoma cells.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 Feb ;15(2):1999-2005. Epub 2017 Nov 24. PMID: 29434900
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, NF-kappaB Inhibitor
Additional Keywords : Natural Substance Synergy, Polysaccharides
[+]

Oridonin induces apoptosis through the mitochondrial pathway in human gastric cancer SGC-7901 cells.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2016 Jun ;48(6):2453-60. Epub 2016 Apr 7. PMID: 27082253
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Oridonin synergistically enhances JQ1-triggered apoptosis in hepatocellular cancer cells through mitochondrial pathway.Dec 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Dec 5 ;8(63):106833-106843. Epub 2017 Oct 16. PMID: 29290992
Article Published Date : Dec 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Cancer Stem Cells
[+]

Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Tumour Biol. 2017 Jun ;39(6):1010428317701638. PMID: 28618955
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2020 Aug ;128:110243. Epub 2020 May 27. PMID: 32470748
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Piperlongumine
Diseases : Intestinal Cancer
Pharmacological Actions : Bcl-2 protein down-regulation, Chemosensitizer, P21 Activation, Survivin Down-Regulation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

"Capsaicin-induced apoptosis of FaDu human pharyngeal squamous carcinoma cells."Jun 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Yonsei Med J. 2012 Jul 1 ;53(4):834-41. PMID: 22665354
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Capsaicin
Diseases : Nasopharyngeal Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

"Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells."Jan 01, 2011

Pubmed Data : Front Biosci (Elite Ed). 2011 ;3:515-28. Epub 2011 Jan 1. PMID: 21196331
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Quercetin, Sulforaphane
Diseases : Cancer Stem Cells, Pancreatic Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Cancer Stem Cells, Drug Synergy
[+]

2-Methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant breast cancer cells through multiple mechanisms.Apr 30, 2011

Pubmed Data : Int J Radiat Oncol Biol Phys. 2011 May 1 ;80(1):231-9. Epub 2011 Mar 9. PMID: 21392897
Article Published Date : Apr 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : 2-Methoxyestradiol
Diseases : Breast Cancer, Breast Cancer: Conventional Treatment, Cancers: Radiation-Resistant, DNA damage, Radiation Induced Illness
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Radiosensitizer
[+]

20(s)-ginsenoside Rg3 is an effective apoptosis-inducing natural compound in ovarian cancer cells.Nov 30, 2014

Pubmed Data : Tumour Biol. 2014 Dec ;35(12):11985-94. Epub 2014 Aug 29. PMID: 25168366
Article Published Date : Nov 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

20S ginsenoside Rh2-activated, distinct apoptosis pathways in highly and poorly differentiated human esophageal cancer cells.Aug 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Aug 31 ;27(17). Epub 2022 Aug 31. PMID: 36080369
Article Published Date : Aug 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Esophageal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

280 nm UV LED irradiation inhibits proliferation and induces apoptosis and necrosis in cultured HL-60 human leukemia cells.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2016 Mar ;13(3):2506-10. Epub 2016 Jan 27. PMID: 26820261
Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Diseases : Leukemia: Acute promyelocytic leukemia
Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Dose Response
[+]

6-shogaol induces apoptosis in Hep-2 cells through inducing oxidative damage and modulate apoptotic marker expressions.Jul 31, 2016

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:226-36. Epub 2016 May 13. PMID: 27470359
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : 6-Shogaol
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

A crude extract of Rheum palmatum has anticancer effects in vitro against Osteosarcoma cells.Feb 16, 2015

Pubmed Data : Environ Toxicol. 2015 Feb 17. Epub 2015 Feb 17. PMID: 25689151
Article Published Date : Feb 16, 2015
Study Type : In Vitro Study
Additional Links
Substances : Rhubarb
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, P21 Activation
[+]

A dichloromethanolic extract of Urtica dioica can successfully induce apoptosis in PC3 cells.Dec 31, 2015

Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2016 ;62(3):78-83. Epub 2016 Mar 31. PMID: 27064877
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Nettle
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemotherapeutic
Additional Keywords : Plant Extracts
[+]

A homogeneous polysaccharide from Huaier inhibited the proliferation of human osteosarcoma cancer cells by promoting apoptosis.Jun 30, 2015

Pubmed Data : Tumour Biol. 2015 Jul ;36(7):5255-63. Epub 2015 Feb 11. PMID: 25666751
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Huaier (Trametes robiniophila murr)
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation
Additional Keywords : Dose Response
[+]

A hot water extract of Chlorella vulgaris could induce 100% inhibition of proliferation and 70% apoptosis rate against HepG2 cells in this study. Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clinics (Sao Paulo). 2010 ;65(12):1371-7. PMID: 21340229
Article Published Date : Dec 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Chlorella (Algae)
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemopreventive, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Dose Response, Plant Extracts
[+]

A ketogenic diet attenuates proliferation and stemness of glioma stem‑like cells by altering metabolism resulting in increased ROS production.Jan 31, 2020

Pubmed Data : Int J Oncol. 2020 Feb ;56(2):606-617. Epub 2019 Dec 13. PMID: 31894296
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Diseases : Glioma
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Hypoxia-inducible factor-1 (HIF-1) inhibitor
Additional Keywords : Cancer Stem Cells
[+]

A new glycoprotein SPG-8700 isolated from sweet potato with potential anti-cancer activity against colon cancer.Mar 11, 2018

Pubmed Data : Nat Prod Res. 2018 Mar 12:1-7. Epub 2018 Mar 12. PMID: 29527942
Article Published Date : Mar 11, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sweet Potato
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

A polysaccharide from Andrographis paniculata induces mitochondrial-mediated apoptosis in human hepatoma cell line.Jun 30, 2015

Pubmed Data : Tumour Biol. 2015 Jul ;36(7):5179-86. Epub 2015 Feb 5. PMID: 25652470
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Andrographis
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Polysaccharides
[+]

A polysaccharide from Glycyrrhiza inflata Licorice inhibits proliferation of human oral cancer cells.May 31, 2015

Pubmed Data : Tumour Biol. 2015 Jun ;36(6):4825-31. Epub 2015 Feb 8. PMID: 25663459
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Licorice
Diseases : Oral Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Polysaccharides
[+]

A studie on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cellsMay 31, 2010

Pubmed Data : Exp Biol Med (Maywood). 2010 Jun ;235(6):751-60. PMID: 20511679
Article Published Date : May 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Acacetin induces apoptosis in human gastric carcinoma cells.Feb 08, 2005

Pubmed Data : J Agric Food Chem. 2005 Feb 9 ;53(3):620-30. PMID: 15686411
Article Published Date : Feb 08, 2005
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Acacetin induces apoptosis in human T cell leukemia Jurkat cells via activation of a caspase cascade.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2012 Jan ;27(1):204-9. Epub 2011 Oct 12. PMID: 21993665
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Acute T cell Leukemias
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Acacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis.Feb 29, 2004

Pubmed Data : Biochem Pharmacol. 2004 Mar 1 ;67(5):823-9. PMID: 15104235
Article Published Date : Feb 29, 2004
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Acacetin-induced apoptosis of human breast cancer MCF-7 cells.Aug 30, 2007

Pubmed Data : Mol Cells. 2007 Aug 31 ;24(1):95-104. PMID: 17846503
Article Published Date : Aug 30, 2007
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Acetogenins could be explored as selective natural inhibitors of Bcl-Xl that could assist in promoting the intrinsic pathway of apoptosis.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2016 ;10:1399-410. Epub 2016 Apr 13. PMID: 27110097
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Graviola
Diseases : Lymphoma: B-Cell
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Acteoside may serve as a novel therapeutic candidate for the treatment of ischemia-reperfusion brain injury.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2018 ;41(11):1645-1651. PMID: 30381663
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Verbascoside
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Neuroprotective Agents, Superoxide Dismutase Up-regulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Aged black garlic extract inhibits the growth of estrogen receptor-positive breast cancer cells.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2023 ;18(6):e0286454. Epub 2023 Jun 23. PMID: 37352173
Article Published Date : Dec 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Garlic: Aged
Diseases : Breast Cancer
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Plant Extracts
[+]

Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway.Dec 31, 2020

Pubmed Data : Chem Biol Drug Des. 2021 02 ;97(2):266-272. Epub 2020 Sep 5. PMID: 32780548
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Leukemia: Monocytic
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Alantolactone induces apoptosis of human cervical cancer cells.May 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Jun ;11(6):4203-4207. Epub 2016 Apr 28. PMID: 27313767
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Cervical Cancer
Pharmacological Actions : Bcl-2 protein down-regulation
[+]

Alkaloids from the Ba lotus seed have anticancer activity through inducing cellular apoptosis.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Nov ;12(5):3113-3120. Epub 2016 Sep 20. PMID: 27882126
Article Published Date : Oct 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation.Sep 15, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2011 Sep 16 ;286(37):32259-67. Epub 2011 Jul 21. PMID: 21778226
Article Published Date : Sep 15, 2011
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Allyl isothiocyanate inhibits the proliferation of renal carcinoma cell line GRC-1Nov 09, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2016 Nov 10 ;22:4283-4288. Epub 2016 Nov 10. PMID: 27834342
Article Published Date : Nov 09, 2016
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates
Diseases : Kidney Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Isothiocyanates
[+]

Aloin promotes A549 cell apoptosis via the reactive oxygen species‑mitogen activated protein kinase signaling pathway and p53 phosphorylation.Oct 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Nov ;16(5):5759-5768. Epub 2017 Aug 29. PMID: 28901386
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

An anticancer peptide from Momordica charantia could activate apoptosis in human colon cancer cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 ;6:33532. Epub 2016 Sep 15. PMID: 27628414
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Bitter Melon
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

An antioxidant rich fraction of white mulberry stem bark inhibits the growth of Ehrlich ascites carcinoma cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(12):e0167536. Epub 2016 Dec 9. PMID: 27936037
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : White Mulberry
Diseases : Ehrlich carcinoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

An extract of Lotus may be a powerful agent against colon cancer cells.Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2017 Mar ;13(3):1470-1478. Epub 2016 Dec 28. PMID: 28454279
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Apoptotic, Bcl-2 protein down-regulation, COLON CANCER, Lotus, Plant Extracts
[+]

Andrographolide inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cell line.Dec 31, 2017

Pubmed Data : Pharmazie. 2018 10 1 ;73(10):594-597. PMID: 30223924
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Anti-cancer effects of queen bee acid and its cellular mechanisms against human hepatoma cells.Feb 18, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2023 Feb 19 ;28(4). Epub 2023 Feb 19. PMID: 36838959
Article Published Date : Feb 18, 2023
Study Type : In Vitro Study
Additional Links
Substances : Bee Products
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
[+]

Anti-cancer properties of theaflavins. Feb 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Feb 13 ;26(4). Epub 2021 Feb 13. PMID: 33668434
Article Published Date : Feb 12, 2021
Study Type : Review
Additional Links
Substances : Theaflavins
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Anti-proliferative activity of biochanin A in human osteosarcoma cells via mitochondrial-involved apoptosis.Jan 31, 2018

Pubmed Data : Food Chem Toxicol. 2018 Feb ;112:194-204. Epub 2018 Jan 3. PMID: 29305928
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation
Additional Keywords : Plant Extracts
[+]

Anticancer potential of Carica papaya Linn black seed extract against human colon cancer cell line.Jul 28, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2023 Jul 29 ;23(1):271. Epub 2023 Jul 29. PMID: 37516866
Article Published Date : Jul 28, 2023
Study Type : In Vitro Study
Additional Links
Substances : Papaya
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Plant Extracts
[+]

Anticancer properties of curcumin-treated Lactobacillus plantarum against the HT-29 colorectal adenocarcinoma cells.Feb 16, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2023 Feb 17 ;13(1):2860. Epub 2023 Feb 17. PMID: 36801895
Article Published Date : Feb 16, 2023
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Lactobacillus plantarum
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Anticancer properties of red beetroot hydro-alcoholic extract and its main constituent; betanin on colorectal cancer cell lines.Jul 17, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Med Ther. 2023 Jul 18 ;23(1):246. Epub 2023 Jul 18. PMID: 37464362
Article Published Date : Jul 17, 2023
Study Type : In Vitro Study
Additional Links
Substances : Beet
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Anticolon cancer effect of Korean red ginseng via autophagy- and apoptosis-mediated cell death.Aug 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Aug 29 ;14(17). Epub 2022 Aug 29. PMID: 36079818
Article Published Date : Aug 28, 2022
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Antineoplaston A10 (synthetic) induced programmed cell death in human liver cancer cells. Jul 01, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2007 Jul-Aug;27(4B):2427-31. PMID: 17695534
Article Published Date : Jul 01, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Antiproliferation and apoptosis induction of paeonol in human esophageal cancer cell lines.Dec 31, 2007

Pubmed Data : Dis Esophagus. 2008 ;21(8):723-9. Epub 2008 Jun 2. PMID: 18522637
Article Published Date : Dec 31, 2007
Study Type : In Vitro Study
Additional Links
Substances : Peony
Diseases : Esophageal Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Antitumor and apoptosis induction effects of paeonol on mice bearing EMT6 breast carcinoma.Jun 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2014 Jul ;22(4):341-6. PMID: 25143814
Article Published Date : Jun 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Antitumor effects of ginsenoside Rg3 on human hepatocellular carcinoma cells.Apr 30, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2012 May ;5(5):1295-8. Epub 2012 Feb 23. PMID: 22366885
Article Published Date : Apr 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Apigenin could be used to potentially increase the effects of cisplatin by targeting cancer stem cells subset in prostate cancer.Mar 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr ;88:210-217. Epub 2017 Jan 17. PMID: 28107698
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Prostate Cancer, Wound Healing
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemosensitizer, P21 Activation
Additional Keywords : Cancer Stem Cells, Chemotherapeutic Synergy: Cisplatin
[+]

Apoptotic effect of berberine via Bcl-2, ROR1, and mir-21 in patients with B-chronic lymphocytic leukemia.Nov 09, 2020

Pubmed Data : Phytother Res. 2020 Nov 10. Epub 2020 Nov 10. PMID: 33174291
Article Published Date : Nov 09, 2020
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Chronic Lymphocytic Leukemia
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, MicroRNA modulator
[+]

Apoptotic effects of bovine apo-lactoferrin on HeLa tumor cells.Dec 31, 2016

Pubmed Data : Cell Biochem Funct. 2017 Jan ;35(1):33-41. Epub 2017 Jan 3. PMID: 28052347
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lactoferrin
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Artemisia leaf extract induces apoptosis in human endometriotic cells through regulation of the p38 and NFκB pathways.Feb 12, 2013

Pubmed Data : J Ethnopharmacol. 2013 Feb 13 ;145(3):767-75. Epub 2012 Dec 8. PMID: 23228915
Article Published Date : Feb 12, 2013
Study Type : In Vitro Study
Additional Links
Substances : Japanese mugwort
Diseases : Endometriosis
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Artemisia princeps var orientalis induces apoptosis in human breast cancer MCF-7 cells.Oct 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2007 Nov-Dec;27(6B):3891-8. PMID: 18225547
Article Published Date : Oct 31, 2007
Study Type : In Vitro Study
Additional Links
Substances : Japanese mugwort
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin, Plant Extracts
[+]

Artemisinin could be an alternative treatment for oral squamous cell carcinoma.Jun 30, 2004

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2004 Jul-Aug;24(4):2153-60. PMID: 15330155
Article Published Date : Jun 30, 2004
Study Type : In Vitro Study
Additional Links
Substances : Artemisinin
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antineoplastic Agents, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis.Apr 19, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2022 Apr 20 ;13(4):379. Epub 2022 Apr 20. PMID: 35443722
Article Published Date : Apr 19, 2022
Study Type : In Vitro Study
Additional Links
Substances : Artesunate
Diseases : Leukemia: Acute myelogenous leukemia (AML)
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Asiatic acid may be a valuable agent for molecular targeted therapy of human acute leukemia.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Jul ;12(1):1429-34. Epub 2015 Mar 24. PMID: 25815462
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Leukemia, Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Astaxanthin demonstrates anti-cancer activity against liver cancer.Jan 01, 2011

Pubmed Data : Biol Pharm Bull. 2011;34(6):839-44. PMID: 21628881
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation
[+]

Astaxanthin functions as a potent inhibitor of A549 lung cancer cell growth.May 31, 2016

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Jun ;32(6):784-8. PMID: 27371847
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, STAT3 Inhibitor
Additional Keywords : Dose Response
[+]

Baicalin attenuates XRCC1-mediated DNA repair to enhance the sensitivity of lung cancer cells to cisplatin.Mar 14, 2021

Pubmed Data : J Recept Signal Transduct Res. 2021 Mar 15:1-10. Epub 2021 Mar 15. PMID: 33719846
Article Published Date : Mar 14, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Benzyl isothiocyanate induces apoptosis of GBM 8401 human brain glioblastoma multiforms cells.Nov 30, 2016

Pubmed Data : Environ Toxicol. 2016 Dec ;31(12):1751-1760. Epub 2015 Sep 7. PMID: 28675694
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Isothiocyanates
[+]

Berberine and evodiamine acts synergistically to suppress the proliferation of MCF-7 cells.Jan 10, 2017

Pubmed Data : Anticancer Res. 2017 11 ;37(11):6141-6151. PMID: 29061795
Article Published Date : Jan 10, 2017
Study Type : In Vitro Study
Additional Links
Substances : Berberine, Evodiamine
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Natural Substance Synergy
[+]

Berberine induces cell death in human glioblastoma cellsJan 01, 2010

Pubmed Data : Biol Pharm Bull. 2010 ;33(10):1644-9. PMID: 20930370
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Glioblastoma, Oxidative Stress
Pharmacological Actions : Antioxidants, Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Beta-elemene is a promising chemosensitizer or adjuvant therapeutic for temozolomide against glioblastoma brain tumors.Jul 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2014 Aug ;10(2):1122-8. Epub 2014 May 27. PMID: 24866280
Article Published Date : Jul 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Cancers: Drug Resistant, Glioblastoma
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Temozolomide
[+]

Beta-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells.Aug 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Sep ;93:490-497. Epub 2017 Jun 30. PMID: 28672279
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Beta-sesquiphellandrenehas anticancer potential that was comparable to that of curcumin.Nov 30, 2015

Pubmed Data : Invest New Drugs. 2015 Dec ;33(6):1175-86. Epub 2015 Nov 2. PMID: 26521943
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Beta-sesquiphellandrene, Turmeric
Diseases : Colorectal Cancer, Leukemia, Lung Cancer, Multiple Myeloma
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Bcl-xL down-regulation, Survivin Down-Regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells.Sep 30, 2006

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2006 Oct ;374(1):11-20. Epub 2006 Sep 9. PMID: 16964520
Article Published Date : Sep 30, 2006
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer, Colon Cancer, Glioma, Lung Cancer, Neuroblastoma, Rhabdomyosarcoma, Thyroid Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation
[+]

Betulinic acid promotes TRAIL function on liver cancer progression inhibition through p53/Caspase-3 signaling activation.Mar 31, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr ;88:349-358. Epub 2017 Jan 21. PMID: 28119237
Article Published Date : Mar 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Betulinic acid-mediated apoptosis in human prostate cancer cells involves p53 and NF-κB pathways.Feb 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Feb 10 ;22(2). Epub 2017 Feb 10. PMID: 28208611
Article Published Date : Feb 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemopreventive, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Biochanin-A induces apoptosis and suppresses migration in FaDu human pharynx squamous carcinoma cells.Oct 31, 2017

Pubmed Data : Oncol Rep. 2017 Nov ;38(5):2985-2992. Epub 2017 Sep 13. PMID: 28901495
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Head and Neck Cancer, Squamous cell carcinoma
Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Bisdemethoxycurcumin enhances X-ray-induced apoptosis possibly through p53/Bcl-2 pathway.Feb 28, 2017

Pubmed Data : Mutat Res. 2017 Mar ;815:1-5. Epub 2017 Jan 11. PMID: 28283087
Article Published Date : Feb 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Bisdemethoxycurcumin
Diseases : Leukemia: T-cell acute Lymphoblastic
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Radiosensitizer, Tumor Suppressor Protein p53 Upregulation
[+]

Boswellia ovalifoliolata abrogates ROS mediated NF-κB activation, causes apoptosis and chemosensitization in triple negative breast cancer cells.Jun 30, 2014

Pubmed Data : Environ Toxicol Pharmacol. 2014 Jul ;38(1):58-70. Epub 2014 May 14. PMID: 24908637
Article Published Date : Jun 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Frankincense
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Cancers: Drug Resistant
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin, Plant Extracts
[+]

Bromelain has anti-tumor initiating activity against skin cancer cells.Sep 18, 2009

Pubmed Data : Cancer Lett. 2009 Sep 18;282(2):167-76. Epub 2009 Mar 31. PMID: 19339108
Article Published Date : Sep 18, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Bromelain may have anti-skin tumor activity. Jan 01, 2008

Pubmed Data : Toxicol Appl Pharmacol. 2008 Jan 1;226(1):30-7. Epub 2007 Aug 23. PMID: 17889918
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Bromelain
Diseases : Skin Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Bufalin could be used as an anti-cancer agent for the treatment of osteosarcoma.Mar 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Mar 10 ;22(3). Epub 2017 Mar 10. PMID: 28287444
Article Published Date : Mar 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Bufalin
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Bufalin induced apoptosis in SCC‑4 human tongue cancer cells.Nov 30, 2017

Pubmed Data : Mol Med Rep. 2017 Dec ;16(6):7959-7966. Epub 2017 Sep 28. PMID: 28983595
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Bufalin
Diseases : Tongue Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

C. gigantea extract may be a significant agent for treatment of lung cancer.Jan 27, 2016

Pubmed Data : Cytotechnology. 2016 Jan 28. Epub 2016 Jan 28. PMID: 26820971
Article Published Date : Jan 27, 2016
Study Type : In Vitro Study
Additional Links
Substances : Mushrooms: All
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

C. tinctorius extract prevented the LPS-induced apoptotic response through IGF-I pathway.Nov 30, 2019

Pubmed Data : Environ Toxicol. 2019 Dec ;34(12):1320-1328. Epub 2019 Sep 4. PMID: 31486215
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Safflower
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Cafestol could have potential as a therapeutic agent for preventing cancers such as renal carcinoma.Apr 24, 2011

Pubmed Data : Chem Biol Interact. 2011 Apr 25 ;190(2-3):102-8. Epub 2011 Feb 18. PMID: 21334318
Article Published Date : Apr 24, 2011
Study Type : In Vitro Study
Additional Links
Substances : Cafestol
Diseases : Kidney Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Caffeic acid phenethyl ester augmented tamoxifen cytotoxicity via multiple mechanisms.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2016 ;2016:3017108. Epub 2015 Nov 30. PMID: 26697130
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Synergy with Tamoxifen
[+]

Cannabidiol and cannabigerol inhibit cholangiocarcinoma growth.Jan 19, 2022

Pubmed Data : Biomolecules. 2022 06 20 ;12(6). Epub 2022 Jun 20. PMID: 35740979
Article Published Date : Jan 19, 2022
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol, Cannabigerol , Cannabinoids
Diseases : Cholangiocarcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Cannabidiol and Cannabis Sativa as a potential treatment in vitro prostate cancer cells.Apr 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Biol Rep. 2023 May ;50(5):4039-4047. Epub 2023 Feb 28. PMID: 36853473
Article Published Date : Apr 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol, Cannabis
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Plant Extracts
[+]

Carnosic acid encapsulated in albumin nanoparticles has been introduced as a promising formula for treating breast and colorectal cancer.Jun 24, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Jun 25 ;27(13). Epub 2022 Jun 25. PMID: 35807348
Article Published Date : Jun 24, 2022
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Breast Cancer, Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors
[+]

Carnosic acid enhances sensitization against TRAIL-mediated apoptosis through the down-regulation of c-FLIP and Bcl-2 expression.Jan 29, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Jan 30 ;6(3):1556-68. PMID: 25596735
Article Published Date : Jan 29, 2015
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Breast Cancer: Triple Negative , Kidney Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Tumor Suppressor Protein p53 Upregulation
[+]

Carnosic acid induced apoptosis in HCT116 cells via generation of ROS, induction of p53, activation of caspases, and inhibition of STAT3 signaling pathway.Jul 07, 2015

Pubmed Data : Mol Carcinog. 2015 Jul 8. Epub 2015 Jul 8. PMID: 26152521
Article Published Date : Jul 07, 2015
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, STAT3 Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Celastrol induces vincristine multidrug resistance oral cancer cell apoptosis by targeting JNK1/2 signaling pathway.Feb 14, 2019

Pubmed Data : Phytomedicine. 2019 Feb 15 ;54:1-8. Epub 2018 Sep 17. PMID: 30668359
Article Published Date : Feb 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Celastrol
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Oral Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Cell death by Gallotannin is associated with inhibition of the JAK/STAT pathway in human colon cancer cells.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Ther Res Clin Exp. 2020 ;92:100589. Epub 2020 Jun 13. PMID: 32714471
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Gallotannins
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.Aug 18, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : iScience. 2022 Aug 19 ;25(8):104773. Epub 2022 Jul 20. PMID: 35992091
Article Published Date : Aug 18, 2022
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Colorectal Cancer
Pharmacological Actions : Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation
[+]

Chrysanthemum indicum can inhibit the proliferation of osteosarcoma cell line Saos-2.Oct 31, 2013

Pubmed Data : Zhong Yao Cai. 2013 Nov ;36(11):1823-7. PMID: 24956827
Article Published Date : Oct 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Chrysanthemum Indicum
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Dose Response
[+]

Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells.Apr 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2022 May ;29(5):3838-3847. Epub 2022 Mar 9. PMID: 35844432
Article Published Date : Apr 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Capsaicin, Chrysin
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Chrysin may be a potential candidate agent for the induction of cell apoptosis in human HCC.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2016 Jul ;12(1):469-474. Epub 2016 Apr 20. PMID: 27347080
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Chrysin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Cinnamomum zeylanicum extract and its bioactive component cinnamaldehyde show anti-tumor effects.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:918479. Epub 2022 Jun 2. PMID: 35774603
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Cinnamaldehyde, Cinnamon
Diseases : Oral Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Combination of tanshinone IIA and cisplatin inhibits esophageal cancer.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2020 ;10:1756. Epub 2020 Sep 10. PMID: 33014864
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, P21 Activation, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Combination of α-tomatine and curcumin more potently inhibited the growth of PC-3 tumors than either agent alone. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015;10(12):e0144293. Epub 2015 Dec 2. PMID: 26630272
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Tomato
Diseases : Prostate Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, NF-kappaB Inhibitor
Additional Keywords : Natural Substance Synergy
[+]

Cordycepin induces apoptosis in human breast cancer cells via caspase-dependent pathways.Dec 31, 2015

Pubmed Data : Nat Prod Commun. 2016 Jan ;11(1):63-8. PMID: 26996021
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cordyceps sinensis
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Cordyceps militaris exerts anticancer effect on non–small cell lung cancer.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2020 Jan-Dec;19:1534735420923756. PMID: 32456485
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Cordyceps Militaris
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation
[+]

Crocetin imparts antiproliferative activity in hepatocellular carcinoma.Sep 11, 2021

Pubmed Data : IUBMB Life. 2021 Sep 12. Epub 2021 Sep 12. PMID: 34514729
Article Published Date : Sep 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor, Survivin Down-Regulation, Vascular Endothelial Growth Factor Inhibitors
[+]

Crocin has therapeutic and preventive effects on cancer cell lines.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Jan ;23(1):3-12. PMID: 32405344
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Breast Cancer, Colorectal Cancer, Leukemia: Chronic myelogenous leukemia (CML) , Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Telomerase Inhibitor
[+]

Crocin promotes apoptosis of human skin cancer cells.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Dec ;16(6):5079-5084. Epub 2018 Oct 16. PMID: 30542463
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Skin Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Crocin significantly suppressed the proliferation of human lung adenocarcinoma cells and enhanced the chemo sensitivity.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Lung Cancer Res. 2015 Dec ;4(6):775-83. PMID: 26798587
Article Published Date : Nov 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Dose Response
[+]

Cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis in human colorectal cancer cell lines.Jul 15, 2015

Pubmed Data : Hum Exp Toxicol. 2015 Jul 16. Epub 2015 Jul 16. PMID: 26183715
Article Published Date : Jul 15, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Chemotherapeutic Synergy: Gefitinib
[+]

Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activitiesNov 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Nov 28 ;8(61):103167-103181. Epub 2017 Oct 9. PMID: 29262554
Article Published Date : Nov 27, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Survivin Down-Regulation
[+]

Cucurbitacin B may prove to be a useful approach for the chemotherapy of lung cancer.Nov 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2014 Dec ;10(6):2905-11. Epub 2014 Sep 18. PMID: 25242136
Article Published Date : Nov 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, STAT3 Inhibitor
Additional Keywords : Dose Response
[+]

Curcumin and capsaicin regulate apoptosis and alleviate intestinal inflammation induced by Clostridioides difficile.Sep 25, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Clin Microbiol Antimicrob. 2022 Sep 26 ;21(1):41. Epub 2022 Sep 26. PMID: 36155114
Article Published Date : Sep 25, 2022
Study Type : In Vitro Study
Additional Links
Substances : Capsaicin, Curcumin
Diseases : Clostridium Infections, Inflammation
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Bcl-2 protein down-regulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin has antiproliferative and proapoptotic activities on human melanoma A375 cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genet Mol Res. 2015 ;14(1):1056-67. Epub 2015 Feb 6. PMID: 25730045
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Melanoma
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Curcumin induces programmed cell death in a murine mammary gland cells. Oct 01, 2011

Pubmed Data : Eur J Pharmacol. 2011 Oct 1 ;668(1-2):127-32. Epub 2011 Jul 8. PMID: 21762689
Article Published Date : Oct 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
[+]

Curcumin induces programmed cell death in human liver cancer cells.Aug 01, 1996

Pubmed Data : Oncogene. 1996 Aug 1;13(3):609-16. PMID: 8760302
Article Published Date : Aug 01, 1996
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumin induces programmed cell death in mouse breast cancer cells. Nov 02, 2001

Pubmed Data : Biochem Biophys Res Commun. 2001 Nov 2;288(3):658-65. PMID: 11676493
Article Published Date : Nov 02, 2001
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Curcumin inhibits human leukemia cells.Nov 15, 1996

Pubmed Data : Biochim Biophys Acta. 1996 Nov 15;1317(2):95-100. PMID: 8950193
Article Published Date : Nov 15, 1996
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Promyelocytic leukemia
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Apoptotic, Bcl-2 protein down-regulation, Oncogene Suppressor
[+]

Curcumin is a multi-targeting agent, simultaneously activating the tumor suppressor p53/p73 pathways and inhibiting pro-apoptotic p-AKT and Bcl-2 levels. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(4):e0124218. Epub 2015 Apr 24. PMID: 25910231
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Carcinoma: Non-Small-Cell Lung, Head and Neck Cancer, Head and Neck Neoplasms, Lung Cancer, Lung Cancer: Metastatic
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumin is capable of inducing programmed cell death in gastric cancer cells. Nov 01, 2011

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov ;27(11):1227-30. PMID: 22078453
Article Published Date : Nov 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation
[+]

Curcumin prevents tumor-induced T cell apoptosis.Mar 24, 2011

Pubmed Data : Behav Brain Res. 2011 Mar 24. Epub 2011 Mar 24. PMID: 17392282
Article Published Date : Mar 24, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
[+]

Curcumin reduces the expression of malignancy-associated Bcl-2 in breast cancer cells.Dec 01, 2010

Pubmed Data : Med Oncol. 2010 Dec;27(4):1114-8. Epub 2009 Nov 12. PMID: 19908170
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer
Pharmacological Actions : Bcl-2 protein down-regulation
[+]

Curcumin works synergistically with bortezomib in multiple myeloma. Jun 01, 2011

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Jun ;19(3):684-8. PMID: 21729550
Article Published Date : Jun 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Drug: Bortezomib, Drug Synergy
[+]

Cyanidin-3-glucoside had an apoptogenic effect in the glioblastoma multiforme cell line.Nov 30, 2017

Pubmed Data : World Neurosurg. 2017 Dec ;108:94-100. Epub 2017 Sep 1. PMID: 28867321
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cyanidin 3-glucoside
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Cytotoxic effect of Eucalyptus citriodora resin on human hepatoma HepG2 cells.Dec 31, 2011

Pubmed Data : Am J Chin Med. 2012 ;40(2):399-413. PMID: 22419432
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Eucalyptus
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

D-limonene exerts its cytotoxic effect on BGC-823 gastric cancer cells by inducing apoptosis.Jun 30, 2003

Pubmed Data : Zhonghua Zhong Liu Za Zhi. 2003 Jul ;25(4):325-7. PMID: 12921557
Article Published Date : Jun 30, 2003
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Data support the potential for using the agent thymoquinone for the treatment of colon cancer.Sep 30, 2004

Pubmed Data : Int J Oncol. 2004 Oct ;25(4):857-66. PMID: 15375533
Article Published Date : Sep 30, 2004
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Daucus Carota oil extracts inhibited cell proliferation by inducing cell cycle arrest and apoptosis in HT-29 cells.Jan 18, 2015

Pubmed Data : J Med Food. 2015 Jan 19. Epub 2015 Jan 19. PMID: 25599142
Article Published Date : Jan 18, 2015
Study Type : In Vitro Study
Additional Links
Substances : Carrot
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Cell cycle arrest, PI3K/Akt/signaling suppression
Additional Keywords : Plant Extracts
[+]

Demethoxycurcumin induces programmed cell death in human glioma cells. Jul 10, 2009

Pubmed Data : Biochem Biophys Res Commun. 2009 Jul 10;384(4):420-5. Epub 2009 May 5. PMID: 19422808
Article Published Date : Jul 10, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Demethoxycurcumin
Diseases : Glioma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Demethoxycurcumin may be a promising photosensitizer for use in photodynamic therapy to induce apoptosis in skin cancer cells.May 31, 2017

Pubmed Data : Tumour Biol. 2017 Jun ;39(6):1010428317706216. PMID: 28618944
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Demethoxycurcumin
Diseases : Skin Cancer
Therapeutic Actions : Sunlight exposure, Sunlight Exposure: UVB Light
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Photosensitizing Agents
[+]

Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2.Feb 28, 2019

Pubmed Data : Food Chem Toxicol. 2019 Mar ;125:354-360. Epub 2019 Jan 22. PMID: 30677442
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Garlic, Organosulfur Compounds
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation
[+]

Diallyl disulfide induces apoptosis and autophagy in human osteosarcoma.Jul 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Jul 23 ;24(14). Epub 2019 Jul 23. PMID: 31340526
Article Published Date : Jul 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Garlic, Organosulfur Compounds
Diseases : Osteosarcoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Dietary flavonoid carvacrol triggers the apoptosis of human breast cancer MCF-7 cells via the p53/Bax/Bcl-2 axis.Dec 09, 2022

Pubmed Data : Med Oncol. 2022 Dec 10 ;40(1):46. Epub 2022 Dec 10. PMID: 36495389
Article Published Date : Dec 09, 2022
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

diosgenin showed anti-tumor effects in glioblastoma cells.Sep 30, 2020

Pubmed Data : Neurochem Res. 2020 Oct ;45(10):2336-2351. Epub 2020 Jul 18. PMID: 32683533
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Diosgenin
Diseases : Glioblastoma
Pharmacological Actions : Anti-Angiogenic, Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

E2F1-directed activation of Bcl-2 is correlated with lactoferrin-induced apoptosis in Jurkat leukemia T lymphocytes.May 31, 2010

Pubmed Data : Biometals. 2010 Jun ;23(3):507-14. Epub 2010 Apr 22. PMID: 20411301
Article Published Date : May 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Lactoferrin
Diseases : Acute T cell Leukemias
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Effect of oridonin on apoptosis and intracellular reactive oxygen species level in triple-negative breast cancer MDA-MB-231 cells.May 31, 2017

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2017 Jun ;42(12):2361-2365. PMID: 28822194
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Effect of tanshinone II A to B7H3 expression in human nasopharyngeal carcinoma CNE1 cell lines.Jan 31, 2013

Pubmed Data : Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Feb ;27(4):199-202. PMID: 23631135
Article Published Date : Jan 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
[+]

Effects of beta-elemene on proliferation and apoptosis of human multiple myeloma cell RPMI-8226Mar 31, 2010

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Apr ;18(2):368-71. PMID: 20416170
Article Published Date : Mar 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Multiple Myeloma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Effects of D-limonene on leukemia cells HL-60 and K562 in vitroJul 31, 2006

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Aug ;14(4):692-5. PMID: 16928301
Article Published Date : Jul 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : D-Limonene
Diseases : Leukemia: Chronic myelogenous leukemia (CML) , Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Effects of deguelin on the proliferation and apoptosis of human esophageal cancer cell Ec-109: an experimental research.Feb 28, 2013

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Mar ;33(3):397-400. PMID: 23713258
Article Published Date : Feb 28, 2013
Study Type : In Vitro Study
Additional Links
Substances : Deguelin
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Emodin sensitizes cervical cancer cells to vinblastine.Jul 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2022 Jul 31 ;23(15). Epub 2022 Jul 31. PMID: 35955645
Article Published Date : Jul 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Emodin
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer
[+]

Enhancement of immune activation activities of Spirulina maxima grown in deep-sea water.Jun 05, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2013 Jun 6 ;14(6):12205-21. Epub 2013 Jun 6. PMID: 23743830
Article Published Date : Jun 05, 2013
Study Type : In Vitro Study
Additional Links
Substances : Spirulina
Diseases : Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Immunomodulatory, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Epigallocatechin gallate inhibits nitric oxide-induced apoptosis in rat PC12 cells.Jan 16, 2007

Pubmed Data : Neurosci Lett. 2007 Jan 16 ;411(3):222-7. Epub 2006 Nov 20. PMID: 17116366
Article Published Date : Jan 16, 2007
Study Type : In Vitro Study
Additional Links
Substances : Catechin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Bcl-2 protein down-regulation, Neuroprotective Agents
[+]

Essential oil from Toona sinensis possessed antibacterial activity against Staphylococcus aureus and significant cytotoxicity against cancer cells.May 27, 2014

Pubmed Data : J Ethnopharmacol. 2014 May 28 ;154(1):198-205. Epub 2014 Apr 12. PMID: 24726685
Article Published Date : May 27, 2014
Study Type : In Vitro Study
Additional Links
Substances : Toona sinensis
Diseases : Liver Cancer, Staphylococcus aureus infection
Pharmacological Actions : Anti-Bacterial Agents, Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Essential Oils
[+]

Ethanolic extract Ocimum sanctum induces an apoptosis in human lung adenocarcinoma (A549) cells.Oct 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2019 Nov ;5(11):e02772. Epub 2019 Nov 14. PMID: 31844708
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Holy Basil
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Eugenol exerts apoptotic effect and modulates the sensitivity of HeLa cells to cisplatin and radiation.Nov 02, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Nov 3 ;24(21). Epub 2019 Nov 3. PMID: 31684176
Article Published Date : Nov 02, 2019
Study Type : In Vitro Study
Additional Links
Substances : Eugenol
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Chemosensitizer, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function.Dec 03, 2015

Pubmed Data : J Ethnopharmacol. 2015 Dec 4 ;175:229-40. Epub 2015 Sep 2. PMID: 26342523
Article Published Date : Dec 03, 2015
Study Type : In Vitro Study
Additional Links
Substances : Woodfordia fruticosa
Diseases : Hyperglycemia, Oxidative Stress
Pharmacological Actions : Antioxidants, Bcl-2 protein down-regulation, Hypoglycemic Agents
Additional Keywords : Plant Extracts
[+]

Extracts of Clinacanthus nutans promote apoptosis in breast cancer cells. Nov 30, 2017

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):394-401. PMID: 27931178
Article Published Date : Nov 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Clinacanthus nutans
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Plant Extracts
[+]

Farrerol exhibits inhibitory effects on lung adenocarcinoma cells.Sep 30, 2022

Pubmed Data : J Biochem Mol Toxicol. 2022 Oct ;36(10):e23157. Epub 2022 Jul 14. PMID: 35833306
Article Published Date : Sep 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Ferruginol induced apoptosis in non-small cell lung cancer (NSCLC) cells in a xenograft animal model.Dec 31, 2014

Pubmed Data : Integr Cancer Ther. 2015 Jan ;14(1):86-97. Epub 2014 Oct 28. PMID: 25355727
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Cryptomeria japonica
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest
Additional Keywords : Dose Response
[+]

Flavonoids from persimmon leaves inhibit proliferation and induce apoptosis in PC-3 cells.Sep 24, 2017

Pubmed Data : Chem Biol Interact. 2017 Sep 25 ;275:210-217. Epub 2017 Aug 12. PMID: 28811126
Article Published Date : Sep 24, 2017
Study Type : In Vitro Study
Additional Links
Substances : Persimmon
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Plant Extracts
[+]

Flax straw metabolites effectively induced growth inhibition and apoptosis in human breast adenocarcinoma cells. Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2016 ;7:282. Epub 2016 Aug 31. PMID: 27630565
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Flax Straw
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Gene Expression Regulation, Metabolites
[+]

Foeniculum vulgare seed extract induces apoptosis in lung cancer cells partly through the down-regulation of Bcl-2. Dec 31, 2020

Pubmed Data : Biomed Pharmacother. 2021 Jan 1 ;135:111213. Epub 2021 Jan 1. PMID: 33395604
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Fennel
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Folic Acid Functionalized Diallyl Trisulfide-solid lipid nanoparticles for targeting triple negative breast cancer.Jan 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2023 Feb 1 ;28(3). Epub 2023 Feb 1. PMID: 36771058
Article Published Date : Jan 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Folic Acid , Organosulfur Compounds
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Folic acid protects motor neurons against the increased homocysteine, inflammation and programmed cell death.Jun 01, 2008

Pubmed Data : Neuropharmacology. 2008 Jun;54(7):1112-9. Epub 2008 Mar 16. PMID: 18436268
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis, Inflammation
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Neuroprotective Agents, Nitric Oxide Inhibitor, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Formononetin and epirubicin may pave the way for a powerful chemotherapeutic regimen for treating human cervical cancer.Oct 04, 2013

Pubmed Data : Chem Biol Interact. 2013 Oct 5 ;205(3):188-97. Epub 2013 Jul 16. PMID: 23867903
Article Published Date : Oct 04, 2013
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Formononetin induces apoptosis in PC-3 prostate cancer cells.Dec 31, 2013

Pubmed Data : Nutr Cancer. 2014 ;66(4):656-61. Epub 2014 Mar 25. PMID: 24666255
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Fucoidan had protective effect against hypoxia-induced cardiomyocytes apoptosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2015 ;53(9):1352-7. Epub 2015 Apr 15. PMID: 25874385
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Hypoxia
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Cardioprotective, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
[+]

Fucoidan has antiproliferative effects in human gastric cancer cell lines.Mar 31, 2011

Pubmed Data : J Food Sci. 2011 Apr ;76(3):T77-83. PMID: 21535865
Article Published Date : Mar 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Gastric Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Autophagy Up-regulation, Bcl-2 protein down-regulation
[+]

Fucoidan induces apoptosis of HepG2 cells by down-regulating p-Stat3.May 31, 2014

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2014 Jun ;34(3):330-336. Epub 2014 Jun 18. PMID: 24939294
Article Published Date : May 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Liver Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Fucoidan induces G1 phase arrest and apoptosis through caspases-dependent pathway and ROS induction in human breast cancer MCF-7 cells.Sep 30, 2013

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2013 Oct ;33(5):717-724. Epub 2013 Oct 20. PMID: 24142726
Article Published Date : Sep 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Fucoidan present in brown algae induces apoptosis of human colon cancer cells.Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Gastroenterol. 2010 ;10:96. Epub 2010 Aug 22. PMID: 20727207
Article Published Date : Dec 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Colon Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Galangin combined with cisplatin suppresses human lung cancer.Dec 31, 2017

Pubmed Data : Biomed Pharmacother. 2018 Jan ;97:213-224. Epub 2017 Nov 6. PMID: 29091869
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Lung Cancer
Pharmacological Actions : Bcl-2 protein down-regulation, NF-kappaB Inhibitor, STAT3 Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Galangin could prove a useful new molecule in the treatment of kidney carcinoma.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J BUON. 2018 May-Jun;23(3):795-799. PMID: 30003754
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Cancer Metastasis, Kidney Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Galangin induces apoptosis in hepatocellular carcinoma cells.Dec 31, 2011

Pubmed Data : J Asian Nat Prod Res. 2012 ;14(7):626-33. Epub 2012 May 10. PMID: 22575016
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Galbanic acid induced antiproliferation in estrogen receptor-negative breast cancer cells Oct 31, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Nov ;33(11):e22402. Epub 2019 Oct 1. PMID: 31576639
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Galbanic Acid
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Gallic acid extracted from the leaves of Phyllanthus emblica exhibits anti-cancer activity against liver cancer. Feb 01, 2011

Pubmed Data : Zhong Yao Cai. 2011 Feb ;34(2):246-9. PMID: 21823485
Article Published Date : Feb 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Gallic Acid, Phyllanthus emblica
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Chemopreventive
[+]

Gallic acid from Terminalia chebula inhibited the growth of esophageal carcinoma cells.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Nov ;23(11):1401-1408. PMID: 33235697
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Gallic Acid, Terminalia chebula
Diseases : Esophageal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Gamma-tocotrienol acts as a BH3 mimetic to induce apoptosis in neuroblastoma SH-SY5Y cells.Feb 08, 2016

Pubmed Data : J Nutr Biochem. 2016 Feb 9 ;31:28-37. Epub 2016 Feb 9. PMID: 27133421
Article Published Date : Feb 08, 2016
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol
Diseases : Neuroblastoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation
[+]

Ganoderma lucidum put forth anti-tumor activity against PC-3 prostate cancer cells.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2020 Oct ;27(10):2632-2637. Epub 2020 Jun 3. PMID: 32994721
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation, STAT3 Inhibitor
[+]

Genistein inhibits triple-negative breast cancer cell growth.Jul 31, 2012

Pubmed Data : Int J Mol Med. 2012 Aug ;30(2):337-43. Epub 2012 May 9. PMID: 22580499
Article Published Date : Jul 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Chemopreventive, NF-kappaB Inhibitor
[+]

Gingerol is a sensitizing agent which induces cell death of TRAIL resistant glioblastoma cells. Sep 14, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Appl Pharmacol. 2014 Sep 15 ;279(3):253-65. Epub 2014 Jul 14. PMID: 25034532
Article Published Date : Sep 14, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ginger, Gingerol
Diseases : Glioblastoma
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, TRAIL sensitizer
Additional Keywords : Apoptosis Regulatory Proteins
[+]

Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells.Apr 30, 2013

Pubmed Data : Bioorg Med Chem Lett. 2013 May 1 ;23(9):2692-5. Epub 2013 Feb 27. PMID: 23523142
Article Published Date : Apr 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Bcl-2 protein down-regulation
[+]

Ginkgetin is a good STAT3 inhibitor and may be a useful lead molecule for development of a therapeutic STAT3 inhibitor.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Sci. 2015 Apr ;106(4):413-20. Epub 2015 Feb 20. PMID: 25611086
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Interleukin-6 Downregulation, STAT3 Inhibitor
[+]

Ginseng oligosaccharides protect neurons from glutamate-induced oxidative damage.Aug 14, 2022

Pubmed Data : Food Funct. 2022 Aug 15 ;13(16):8605-8615. Epub 2022 Aug 15. PMID: 35894549
Article Published Date : Aug 14, 2022
Study Type : In Vitro Study
Additional Links
Substances : Ginseng, Oligosaccharides
Diseases : Brain: Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Bcl-2 protein down-regulation, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Ginsenoside has anticancer effects in SKOV3 cells through inhibition of cell proliferation and induction of apoptosis.Dec 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Res. 2016 Dec 13 ;65(6):1031-1037. PMID: 27959575
Article Published Date : Dec 12, 2016
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation
[+]

Ginsenoside Rf induces G2/M phase cell cycle arrest and apoptosis in human osteosarcoma MG-63 cells.Dec 31, 2013

Pubmed Data : Oncol Rep. 2014 Jan ;31(1):305-13. Epub 2013 Oct 24. PMID: 24173574
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest

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