Caspase-3 Activation

Name	AC	CK
Curcumin	7	11
Bloodroot	2	6
Kahweol	2	6
Lichens	2	6
Tetrahydrocurcumin	2	6
Chrysin	1	5
Curcumin: Degradiation byproducts	1	5
Ginger	1	5
Nigella sativa (aka Black Seed)	1	5
Piperine	1	5
Zerumbone	1	5
Resveratrol	4	4
Berberine	2	3
Betaine	2	3
Cannabidiol	3	3
Melatonin	2	3
Oridonin	3	3
Ursolic Acid	2	3
6-Shogaol	1	2
Apple	1	2
Baicalein	1	2
Beet	1	2
Catechin	2	2
Curcuma Purpurascens	1	2
DHA (Docosahexaenoic Acid)	2	2
Ellagic Acid	1	2
Fish Oil	1	2
Flavonoids	2	2
Fruit Peel	1	2
Ginseng (Korean)	1	2
Mushrooms: All	2	2
Polyphenols	1	2
Polyunsaturated Fatty Acids (PUFAs)	1	2
Pomegranate	1	2
Shemamruthaa	1	2
Shiitake Mushroom	1	2
Shikonin	2	2
Tea	2	2
Tocotrienol: Delta	1	2
Vitamin E	1	2
White Tea	2	2
Alpha-Lipoic Acid	1	1
Apigenin	1	1
Apple Polyphenols	1	1
Berbamine	1	1
Bilberry	1	1
Bisdemethoxycurcumin	1	1
Blackberry	1	1
Cafestol	1	1
Cannabinoids	1	1
Carnosic Acid	1	1
Carrot	1	1
Crocetin	1	1
Crocin	1	1
D-Limonene	1	1
Dandelion	1	1
Demethoxycurcumin	1	1
EPA (Eicosapentaenoic Acid)	1	1
Fucoidan	1	1
Garlic: Aged	1	1
Ginkgo biloba	1	1
Graviola	1	1
Hawthorn	1	1
Holy Basil	1	1
Lion's Mane (Hericium Erinaceus)	1	1
Lithospermum erythrorhizon	1	1
Long Pepper	1	1
Lotus	1	1
Mango Seed	1	1
Medicinal Mushrooms	1	1
Naringenin	1	1
Nobiletin	1	1
Oyster Mushroom	1	1
Pine Cone	1	1
Piperlongumine	1	1
Quercetin	1	1
Red Sage	1	1
Rosemary	1	1
Rutin	1	1
Sulforaphane	1	1
Tangeretin	1	1
Tocotrienol: Gamma	1	1
Tomato	1	1
Tualang Honey	1	1
Turmeric	1	1
Turmerones	1	1
Venom: Snake	1	1
Vitamin D	1	1
Vitamin E: Gamma-tocotrienol	1	1
Xanthohumol	1	1

[+]

Chrysin induces apoptosis of human uveal melanoma cells.Nov 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2016 Dec ;12(6):4813-4820. Epub 2016 Oct 13. PMID: 28105189

Article Published Date : Nov 30, 2016

Study Type : Human In Vitro

Additional Links

Substances : Chrysin

Diseases : Melanoma: Uveal

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Kahweol inhibits colorectal tumor cell growth by promoting apoptosis and suppressing HSP70 expression.Feb 28, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomol Ther (Seoul). 2015 Mar ;23(2):128-33. Epub 2015 Mar 1. PMID: 25767680

Article Published Date : Feb 28, 2015

Study Type : Human In Vitro

Additional Links

Substances : Kahweol

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Heat Shock Protein Down-Regulation

[+]

P. sulcata inhibited the growth in a dose-dependent manner and induced caspase-independent apoptosis at low doses.Apr 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cytotechnology. 2015 May ;67(3):531-43. Epub 2014 Mar 28. PMID: 24676908

Article Published Date : Apr 30, 2015

Study Type : Human In Vitro

Additional Links

Substances : Lichens

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic, Caspase-3 Activation

Additional Keywords : Apoptotic, Breast Cancer, Breast Cancer: Triple Negative, Caspase-3 Activation, Dose Response, Lichens

[+]

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID: 24272201

Article Published Date : Mar 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Piperine

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Selective Cytotoxicity

[+]

Sanguinarine induces apoptosis of human oral squamous cell carcinoma KB cells.Jul 31, 2016

Click here to read the entire abstract

Pubmed Data : Drug Dev Res. 2016 Aug ;77(5):227-40. Epub 2016 Jul 1. PMID: 27363951

Article Published Date : Jul 31, 2016

Study Type : Human In Vitro

Additional Links

Substances : Bloodroot

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Tetrahydrocurcumin exhibited significant cell growth inhibition by inducing MCF-7 cells to undergo mitochondrial apoptosis and G2/M arrest.Apr 30, 2014

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2014 May ;67:193-200. Epub 2014 Mar 1. PMID: 24593988

Article Published Date : Apr 30, 2014

Study Type : Human In Vitro

Additional Links

Substances : Curcumin: Degradiation byproducts, Tetrahydrocurcumin

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Cell cycle arrest, P21 Activation

[+]

Zerumbone was able to induce apoptosis of pancreatic carcinoma cell lines Jan 01, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:936030. Epub 2012 Jan 29. PMID: 22454691

Article Published Date : Jan 01, 2012

Study Type : Human In Vitro

Additional Links

Substances : Ginger, Zerumbone

Diseases : Pancreatic Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Zerumbone

[+]

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27888812

Article Published Date : Nov 20, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Shiitake Mushroom

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, NF-kappaB Inhibitor

Additional Keywords : Polysaccharides

[+]

An extract of Curcuma purpurascens suppressed the proliferation of HT-29 colon cancer cells and triggered the induction of apoptosis through mitochondrial-dependent pathway.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2015 ;15:15. Epub 2015 Feb 5. PMID: 25652758

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcuma Purpurascens

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation

Additional Keywords : Dose Response

[+]

Baicalein could increase caspase-3 and Bax expression and decrease survivin and Bcl-2 to induce apoptosis.Aug 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pancreas. 2017 Sep ;46(8):1076-1081. PMID: 28787336

Article Published Date : Aug 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Baicalein

Diseases : Pancreatic Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Survivin Down-Regulation

[+]

Berberine activates apoptosis to suppress triple-negative breast cancer cells.Aug 17, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Aug 18 ;95:18-24. Epub 2017 Aug 18. PMID: 28826092

Article Published Date : Aug 17, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Betanin significantly inhibits lung tumorigenesis in A/J mice and induces apoptosis in lung cancer cells. Aug 31, 2013

Click here to read the entire abstract

Pubmed Data : Mol Carcinog. 2013 Sep ;52(9):686-91. Epub 2012 Mar 27. PMID: 22456940

Article Published Date : Aug 31, 2013

Study Type : Animal Study

Additional Links

Substances : Beet, Betaine

Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anticarcinogenic Agents, Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Caspase-9 Activation, Chemopreventive

Additional Keywords : Beet, Benzo(a)pyrene, Betaine, lung cancer, Vinyl Carbamate

Problem Substances : Benzo(a)pyrene, Vinyl Carbamate

[+]

Korean Red Ginseng extracts might have the ability to reduce the incidence of leukemia.Sep 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ginseng Res. 2016 Oct ;40(4):431-436. Epub 2016 Aug 4. PMID: 27746697

Article Published Date : Sep 30, 2016

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean)

Diseases : Lymphoma

Pharmacological Actions : Anti-metastatic, Apoptotic, Caspase-3 Activation, Caspase-8 activation, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Plant Extracts

[+]

Melatonin may delay aging in gastric mucosa tissue by decreasing caspase-3 activity.Mar 14, 2011

Click here to read the entire abstract

Pubmed Data : Aging Clin Exp Res. 2011 Mar 14. Epub 2011 Mar 14. PMID: 21406955

Article Published Date : Mar 14, 2011

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Aging

Pharmacological Actions : Anti-Apoptotic, Caspase-3 Activation

[+]

Oral administration of apple procyanidins inhibits the proliferation of tumor cells by inducing apoptosis through the intrinsic mitochondrial pathway.Feb 29, 2008

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 2008 Mar ;29(3):585-93. Epub 2007 Sep 7. PMID: 17827407

Article Published Date : Feb 29, 2008

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Apple

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation

Additional Keywords : Proanthocyanidins

[+]

Our results reveal Flavin7 (F7) had substantial tumour-suppression effects of 58 % and reduced tumour incidence by 24 % in this breast cancer model.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : Eur J Nutr. 2015 May 1. Epub 2015 May 1. PMID: 25930965

Article Published Date : Apr 30, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fruit Peel, Polyphenols

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Bax/Bcl2 Ratio: Decrease, Caspase-3 Activation, Cell cycle arrest, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Dose Response, Plant Extracts

[+]

Pomegranate fruit juice suppressed androgen dependent prostate carcinogenesis.Oct 03, 2014

Click here to read the entire abstract

Pubmed Data : Prostate. 2014 Oct 4. Epub 2014 Oct 4. PMID: 25284475

Article Published Date : Oct 03, 2014

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid, Pomegranate

Diseases : Cancer: Prostate, Prostate Cancer: Prevention

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, Chemopreventive

[+]

The current study clearly indicates that 6-shogaol can be exploited for the prevention and treatment of NSCLC.Feb 28, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Carcinogenesis. 2014 Mar ;35(3):683-91. Epub 2013 Nov 26. PMID: 24282290

Article Published Date : Feb 28, 2014

Study Type : Animal Study

Additional Links

Substances : 6-Shogaol

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer: Prevention

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest, Chemopreventive, STAT3 Inhibitor

[+]

The herbal preparation Shemamruthaa had antiproliferative and apoptotic effects on chemically induced breast cancer.Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : J Evid Based Complementary Altern Med. 2015 Oct ;20(4):259-68. Epub 2015 Apr 17. PMID: 25888591

Article Published Date : Sep 30, 2015

Study Type : Animal Study

Additional Links

Substances : Shemamruthaa

Diseases : Breast Cancer, Breast Cancer: Chemically-Induced

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Tumor Suppressor Protein p53 Upregulation

[+]

The pro-apoptotic effect of FO in Walker 256 tumor is related with specifics cleaved caspases.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Lipids Health Dis. 2015 ;14(1):94. Epub 2015 Aug 25. PMID: 26303118

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)

Diseases : Tumors

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Tumor Suppressor Protein p53 Upregulation

[+]

Tocotrienols are potent antitumor agents capable of inducing apoptosis and inhibiting angiogenesis under both hypoxic and normoxic conditions.Jul 31, 2015

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2015 Aug ;26(8):832-40. Epub 2015 Apr 14. PMID: 25979648

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Tocotrienol: Delta, Vitamin E

Diseases : Colorectal Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, P21 Activation

Additional Keywords : Dose Response

[+]

Ursolic acid exhibits significant anti-tumor effects by suppressing cell proliferation, promoting apoptosis in gallbladder cancer cells. Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2014 ;14(1):96. Epub 2014 Oct 29. PMID: 25383044

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest

Additional Keywords : Dose Response

[+]

A compound within Red Sage (tanshinone) induces programmed cell death in monocyte leukemia cells.Jan 01, 2010

Click here to read the entire abstract

Pubmed Data : Int J Mol Sci. 2010;11(6):2267-80. Epub 2010 May 26. PMID: 20640151

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Red Sage

Diseases : Leukemia

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Telomerase Inhibitor

[+]

A pinecone water extract induced apoptosis associated with caspase-3 activation in A549, H1264, H1299, and Calu-6 lung cancer cells. Dec 26, 2016

Click here to read the entire abstract

Pubmed Data : Chem Biodivers. 2016 Dec 27. Epub 2016 Dec 27. PMID: 28027428

Article Published Date : Dec 26, 2016

Study Type : In Vitro Study

Additional Links

Substances : Pine Cone

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation

[+]

Abrogation of HDGF by EGCG enhances cisplatin-induced apoptosis and sensitizes A549 cells to chemotherapy.Jul 13, 2015

Click here to read the entire abstract

Pubmed Data : Proteomics Clin Appl. 2015 Jul 14. Epub 2015 Jul 14. PMID: 26175166

Article Published Date : Jul 13, 2015

Study Type : In Vitro Study

Additional Links

Diseases : Lung Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

After exposure to different oridonin concentrations, growth rates and cell cycle arrest of BxPC-3 cells were significantly reduced compared with untreated cells.Feb 28, 2015

Click here to read the entire abstract

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2015 Mar ;47(3):164-73. Epub 2015 Feb 3. PMID: 25651847

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Oridonin

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Cell cycle arrest

[+]

An anthocyanin-rich dietary bilberry extract induced a redox-sensitive apoptosis in CLL cells with little effect on healthy peripheral blood mononuclear cells.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2015 ;5:8996. Epub 2015 Mar 11. PMID: 25757575

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Bilberry

Diseases : Chronic Lymphocytic Leukemia

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemotherapeutic

Additional Keywords : Plant Extracts, Selective Cytotoxicity

[+]

An apple flavonoid enriched fraction possessed a significantly stronger antiproliferative and specific action than Sorafenib in vitro.Sep 24, 2014

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2014 Sep 25:1-10. Epub 2014 Sep 25. PMID: 25256427

Article Published Date : Sep 24, 2014

Study Type : In Vitro Study

Additional Links

Substances : Apple Polyphenols, Flavonoids

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest, Chemopreventive, Topoisomerase II Inhibitor

Additional Keywords : Northern Spy Apples, Plant Extracts, Selective Cytotoxicity

[+]

Berbamine exhibited strong anti-prostate cancer activities in vitro and in vivo.Nov 30, 2016

Click here to read the entire abstract

Pubmed Data : Prostate Cancer Prostatic Dis. 2016 Dec ;19(4):358-366. Epub 2016 Jul 19. PMID: 27431500

Article Published Date : Nov 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Berbamine

Diseases : Prostate Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation

Additional Keywords : Dose Response

[+]

Betaine exhibits tumoricidal effects and acts as a biological response modifier in cancer treatment by inducing apoptosis and cell cycle arrest in a dose and time-dependent manner.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(8):3195-201. PMID: 25921120

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Betaine

Diseases : Cervical Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest

Additional Keywords : Dose Response, Higher Dose Better Than Lower Dose

[+]

Bisdemethoxycurcumin induced cell apoptosis through multiple signal pathways such as extrinsic, intrinsic and ES tress pathway.Sep 14, 2015

Click here to read the entire abstract

Pubmed Data : Environ Toxicol. 2015 Sep 15. Epub 2015 Sep 15. PMID: 26370218

Article Published Date : Sep 14, 2015

Study Type : In Vitro Study

Additional Links

Substances : Bisdemethoxycurcumin

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Cell cycle arrest

[+]

Blackberry Ellagitannins showed anti-cancer activity by arresting the cell cycle and inducing apoptosis on HT-29 human colon cancer cells.May 12, 2015

Click here to read the entire abstract

Pubmed Data : Food Funct. 2015 May 13 ;6(5):1675-83. PMID: 25906041

Article Published Date : May 12, 2015

Study Type : In Vitro Study

Additional Links

Substances : Blackberry

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemopreventive, P21 Activation

[+]

Cafestol and kahweol are potential cancer treatments, or adjuvants as chemotherapeutic agents for malignant pleural mesothelioma.Jun 25, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biomed Sci. 2012 Jun 26 ;19:60. Epub 2012 Jun 26. PMID: 22734486

Article Published Date : Jun 25, 2012

Study Type : In Vitro Study

Additional Links

Substances : Cafestol, Kahweol

Diseases : Mesothelioma

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemotherapeutic

[+]

Cannabidiol and cannabidiol-dimethylheptyl and exposure of the cells to gamma irradiation markedly enhanced apoptosis, reaching values of 93 and 95%.Sep 30, 2003

Click here to read the entire abstract

Pubmed Data : Leuk Lymphoma. 2003 Oct ;44(10):1767-73. PMID: 14692532

Article Published Date : Sep 30, 2003

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol, Cannabinoids

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Apoptotic, Caspase-3 Activation

Additional Keywords : Dose Response, Gamma Irradiation, Radiation Synergy

[+]

Cannabidiol is cytotoxic to human glioma cells. Sep 01, 2006

Click here to read the entire abstract

Pubmed Data : Cell Mol Life Sci. 2006 Sep;63(17):2057-66. PMID: 16909207

Article Published Date : Sep 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol

Diseases : Glioma

Pharmacological Actions : Anti-Proliferative, Caspase-3 Activation

[+]

Carnosic acid induced apoptosis in HCT116 cells via generation of ROS, induction of p53, activation of caspases, and inhibition of STAT3 signaling pathway.Jul 07, 2015

Click here to read the entire abstract

Pubmed Data : Mol Carcinog. 2015 Jul 8. Epub 2015 Jul 8. PMID: 26152521

Article Published Date : Jul 07, 2015

Study Type : In Vitro Study

Additional Links

Substances : Carnosic Acid, Rosemary

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, STAT3 Inhibitor, Tumor Suppressor Protein p53 Upregulation

[+]

Combined treatment with low doses of γ-tocotrienol and oridonin for 24 h resulted in synergistic inhibition of +SA mammary cancer cells viability.Jun 26, 2015

Click here to read the entire abstract

Pubmed Data : Mol Cell Biochem. 2015 Jun 27. Epub 2015 Jun 27. PMID: 26112904

Article Published Date : Jun 26, 2015

Study Type : In Vitro Study

Additional Links

Substances : Oridonin, Tocotrienol: Gamma

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Caspase-3 Activation

Additional Keywords : Natural Substance Synergy, Selective Antiproliferation, Selective Cytotoxicity

[+]

Crocetin exerts a prominent chemopreventive effect against esophageal cancer through the inhibition of cell proliferation, migration and induction of apoptosis.Feb 28, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2015 Mar ;9(3):1254-1260. Epub 2015 Jan 13. PMID: 25663893

Article Published Date : Feb 28, 2015

Study Type : In Vitro Study

Additional Links

Substances : Crocetin

Diseases : Esophageal Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Caspase-3 Activation, Chemopreventive

[+]

Crocin can significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase.Jan 31, 2015

Click here to read the entire abstract

Pubmed Data : Nat Prod Commun. 2015 Feb ;10(2):249-52. PMID: 25920253

Article Published Date : Jan 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Crocin

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation

[+]

Curcumin can inhibit the proliferation and induce programmed cell death in melanoma cells.Dec 01, 2005

Click here to read the entire abstract

Pubmed Data : Di Yi Jun Yi Da Xue Xue Bao. 2005 Dec;25(12):1517-21. PMID: 16361152

Article Published Date : Dec 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation

[+]

Curcumin could induce apoptosis in pancreatic cancer cells.Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : Mol Med Rep. 2015 Oct ;12(4):5415-22. Epub 2015 Jul 8. PMID: 26166196

Article Published Date : Sep 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Pancreatic Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 Ratio: Decrease, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest

[+]

Curcumin has the ability to improve the paclitaxel induced apoptosis of HPV positive human cervical cancer cell lines via the NF-κB-p53-caspase-3 pathway.Mar 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2015 Apr ;9(4):1470-1476. Epub 2015 Jan 29. PMID: 25780454

Article Published Date : Mar 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cervical Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Curcumin inhibits cell proliferation and promotes apoptosis in osteoclastoma cell through suppression of MMP-9 and NF-κB, and activation JNK signaling pathways.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(6):6037-45. Epub 2015 Jun 1. PMID: 26261481

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Osteoclastoma

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

[+]

Curcumin inhibits Ewing sarcoma. Dec 01, 2010

Click here to read the entire abstract

Pubmed Data : Med Oncol. 2010 Dec;27(4):1096-101. Epub 2009 Oct 27. PMID: 19859844

Article Published Date : Dec 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Sarcoma: Ewing's

Pharmacological Actions : Caspase-3 Activation, Chemopreventive

[+]

Curcumin is capable of inducing programmed cell death in gastric cancer cells. Nov 01, 2011

Click here to read the entire abstract

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov ;27(11):1227-30. PMID: 22078453

Article Published Date : Nov 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation

[+]

Dandelion Root Extract effectively induces apoptosis in highly aggressive and resistant Chronic Myelomonocytic Leukemia (CMML) cell linesJan 01, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2012 ;7(2):e30604. Epub 2012 Feb 17. PMID: 22363452

Article Published Date : Jan 01, 2012

Study Type : In Vitro Study

Additional Links

Substances : Dandelion

Diseases : Leukemia, Leukemia: Multi-Drug Resistant

Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Caspase-3 Activation, Caspase-8 activation

Additional Keywords : Chronic Myelomonocytic Leukemia, Dose Response, Selective Cytotoxicity

[+]

Daucus Carota oil extracts inhibited cell proliferation by inducing cell cycle arrest and apoptosis in HT-29 cells.Jan 18, 2015

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Jan 19. Epub 2015 Jan 19. PMID: 25599142

Article Published Date : Jan 18, 2015

Study Type : In Vitro Study

Additional Links

Substances : Carrot

Diseases : Colon Cancer, Colon Cancer: Prevention

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Cell cycle arrest, PI3K/Akt/signaling suppression

Additional Keywords : Plant Extracts

[+]

Demethoxycurcumin may induce apoptosis of skin cancer cells through a caspase dependent pathway.Jun 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2017 Jul ;16(1):539-546. Epub 2017 May 31. PMID: 28586041

Article Published Date : Jun 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Demethoxycurcumin

Diseases : Skin Cancer: Squamous Cell

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

DHA and EPA are found to exhibit growth-inhibitory effect on the human neuroblastoma LA-N-1 cells.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2015 ;7(8):6956-73. Epub 2015 Aug 18. PMID: 26295255

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid)

Diseases : Neuroblastoma

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest

[+]

Fucoidan may be a potential therapeutic reagent against the growth of human colon cancer cells.Aug 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2015 Sep ;12(3):3446-52. Epub 2015 May 21. PMID: 25998232

Article Published Date : Aug 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Colon Cancer, Colon Cancer: Prevention

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Caspase-3 Activation

[+]

Ginkgolide B from ginkgo biloba has an antiproliferative and apoptosis-Inducing effect on ovarian cancer cellsApr 13, 2012

Click here to read the entire abstract

Pubmed Data : Integr Cancer Ther. 2012 Apr 13. Epub 2012 Apr 13. PMID: 22505596

Article Published Date : Apr 13, 2012

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Chemosensitizer, Cyclin D1 Down-Regulation, P21 Activation

Additional Keywords : Natural Substances Versus Drugs, Plant Extracts

Problem Substances : Cisplatin

[+]

HEABG reduces leukemic cell growth by inducing caspase-dependent apoptosis through both intrinsic and extrinsic pathways.Mar 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr Res Pract. 2014 Apr ;8(2):132-7. Epub 2014 Mar 28. PMID: 24741395

Article Published Date : Mar 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Garlic: Aged

Diseases : Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation

[+]

Hyperoside and rutin from lotus roots may be the promising candidates for treatment of colon cancer.Mar 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2016 Apr ;11(4):2463-2470. Epub 2016 Feb 18. PMID: 27073499

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lotus , Rutin

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

[+]

In the current study we demonstrated that cannabidiol can induce apoptosis in murine as well as human leukemia cells.Aug 31, 2006

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Pharmacol. 2006 Sep ;70(3):897-908. Epub 2006 Jun 5. PMID: 16754784

Article Published Date : Aug 31, 2006

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol

Diseases : Leukemia

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, NADPH Oxidase Inhibitors

Additional Keywords : Cannabinoid Receptors

[+]

Lichen metabolites showed various cytotoxic effects in a concentration-dependent manner against cancer cells. Feb 28, 2013

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2013 Mar ;27(3):431-7. Epub 2012 May 25. PMID: 22628260

Article Published Date : Feb 28, 2013

Study Type : In Vitro Study

Additional Links

Substances : Lichens

Diseases : Breast Cancer, Cervical Cancer, Colon Cancer, Oxidative Stress

Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

Additional Keywords : Dose Response, Metabolites

[+]

Lion's mane induces programmed cell death in monocytic leukemia cells. Jun 01, 2011

Click here to read the entire abstract

Pubmed Data : Food Funct. 2011 Jun ;2(6):348-56. Epub 2011 Jun 8. PMID: 21779573

Article Published Date : Jun 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Infant Acute Monocytic Leukemia, Leukemia: Monocytic

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2017 Feb ;100:149-160. Epub 2016 Dec 23. PMID: 28025124

Article Published Date : Jan 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Hawthorn, Ursolic Acid

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Cyclin D1 Down-Regulation

Additional Keywords : Antiproliferative, Breast Cancer: Triple Negative, Dose Response, Hawthorn, Ursolic Acid

[+]

Melatonin sensitizes the cisplatin-mediated growth suppression of liver cancer cells.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Cancer Res. 2017 ;7(1):13-27. Epub 2017 Jan 1. PMID: 28123844

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Chemosensitizer, NF-kappaB Inhibitor

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Natural compounds present in oyster mushroom could modulate apoptosis and cell cycle pathways that are frequently blocked in human cancers.Apr 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Iran Med. 2015 May ;18(5):284-95. PMID: 25959910

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Mushrooms: All , Oyster Mushroom

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, P21 Activation

[+]

Oridonin effectively inhibited cell proliferation and induced apoptosis in HCT-116 and LoVo cells in a concentration-dependent manner.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2015 May ;72:125-34. Epub 2015 Apr 27. PMID: 26054686

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Oridonin

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, MicroRNA modulator

Additional Keywords : Dose Response

[+]

P53 and survivin may provide promising targets of docosahexaenoic acid in acute lymphoblastic leukemia cells.Nov 22, 2016

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2016 Nov 23:1-10. Epub 2016 Nov 23. PMID: 27880058

Article Published Date : Nov 22, 2016

Study Type : In Vitro Study

Additional Links

Substances : DHA (Docosahexaenoic Acid)

Diseases : Acute lymphoblastic leukemia (ALL)

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Survivin Down-Regulation, Tumor Suppressor Protein p53 Upregulation

[+]

Piperlongumine and alpha lipoic acid may have a potential value as a therapeutic agent for patients with acute promyelocytic leukemia.Mar 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cancer Res Ther. 2016 Apr-Jun;12(2):556-60. PMID: 27461609

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Alpha-Lipoic Acid, Long Pepper, Piperlongumine

Diseases : Leukemia, Leukemia: Acute promyelocytic leukemia

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemotherapeutic, Cyclooxygenase 2 Inhibitors

Additional Keywords : Natural Substance Synergy

[+]

Quercetin has promising effects on the inhibition of growth, invasion, and metastatic potential of melanoma.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Onco Targets Ther. 2016 ;9:6445-6459. Epub 2016 Aug 19. PMID: 27799792

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Quercetin

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Apoptotic, Caspase-3 Activation, Chemopreventive

[+]

Resveratraol induces cell death in human ovarian cancer cells. Nov 01, 2010

Click here to read the entire abstract

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2010 Nov;30(11):2440-2. PMID: 21097399

Article Published Date : Nov 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Ovarian Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Resveratrol could suppress hyperplasia of synovial cells, a critical factor of rheumatoid arthritis.Aug 10, 2010

Click here to read the entire abstract

Pubmed Data : Rheumatol Int. 2010 Aug 10. Epub 2010 Aug 10. PMID: 20697895

Article Published Date : Aug 10, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Arthritis: Rheumatoid

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Resveratrol induces programmed cell death and suppressioin of neuroendocrine markers in medullary thyroid cancer.Dec 24, 2010

Click here to read the entire abstract

Pubmed Data : Ann Surg Oncol. 2010 Dec 24. Epub 2010 Dec 24. PMID: 21184191

Article Published Date : Dec 24, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Thyroid Cancer

Pharmacological Actions : Anti-Proliferative, Apoptotic, Caspase-3 Activation

[+]

Resveratrol induces programmed cell death in ovarian cancer cells. Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : J Med Food. 2011 Jan-Feb;14(1-2):46-52. Epub 2010 Dec 27. PMID: 21186985

Article Published Date : Jan 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Ovarian Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis.Oct 31, 2009

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Anticancer Res. 2009 Nov ;29(11):4457-65. PMID: 20032392

Article Published Date : Oct 31, 2009

Study Type : In Vitro Study

Additional Links

Substances : Bloodroot

Diseases : Gastric Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemosensitizer

Additional Keywords : Apoptotic, Bloodroot, Caspase-3 Activation, Chemosensitizer, gastric cancer

[+]

Shikonin exhibited its anti-tumor activity against HGC-27 cells through inhibiting cell growth and promoting apoptosis by targeting mitochondrial-related signaling pathway.Mar 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacogn Mag. 2015 Apr-Jun;11(42):250-6. PMID: 25829762

Article Published Date : Mar 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Lithospermum erythrorhizon, Shikonin

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

[+]

Snake venom toxins induces mitochondrial and caspase-3 dependent apoptosis in cancer cell lines.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Pharm Res. 2016 ;15(Suppl):101-112. PMID: 28228809

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Venom: Snake

Diseases : Breast Cancer, Liver Cancer, Prostate Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation

[+]

Sulforaphane induces programmed cell death in human cervical and liver cancer cells through activation of caspase-3. Jul 01, 2007

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2007 Jul;18(1):181-7. PMID: 17549366

Article Published Date : Jul 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Cervical Cancer, Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Caspase-3 Activation

[+]

Tangeretin was found to be a multidrug resistance modulator in resistant cells by sensitizing them to doxorubicin.Nov 25, 2012

Click here to read the entire abstract

Pubmed Data : J Nat Prod. 2012 Nov 26 ;75(11):1896-902. Epub 2012 Nov 8. PMID: 23137376

Article Published Date : Nov 25, 2012

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids, Naringenin , Nobiletin , Tangeretin

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Colon Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin

[+]

Tetrahydrocurcumin is more effective than curcumin in inducing the apoptosis of H22 cells.Aug 01, 2017

Click here to read the entire abstract

Pubmed Data : Food Funct. 2017 Aug 2. Epub 2017 Aug 2. PMID: 28766664

Article Published Date : Aug 01, 2017

Study Type : In Vitro Study

Additional Links

Substances : Tetrahydrocurcumin

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

The combination of berberine and d-limonene exerted synergistic anticancer effects on MGC803 cells by cell-cycle arrest, ROS production, and apoptosis induction.Aug 31, 2014

Click here to read the entire abstract

Pubmed Data : J Med Food. 2014 Sep ;17(9):955-62. Epub 2014 Jul 21. PMID: 25045784

Article Published Date : Aug 31, 2014

Study Type : Plant Study

Additional Links

Substances : Berberine, D-Limonene

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation

Additional Keywords : Dose Response, Natural Substance Synergy, Plant Extracts

[+]

The combined use of 1,25(OH)2D3 and cisplatin may be used as a strategy to overcome resistance to cisplatin and dose limitations, and to improve the anticancer effects of chemotherapy.Apr 30, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2014 May ;33(5):1177-84. Epub 2014 Feb 24. PMID: 24573222

Article Published Date : Apr 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Vitamin D

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

The green tea polyphenol EGCG enhances the anti-cancer activity of bortezomib in multiple myeloma cells. Dec 01, 2009

Click here to read the entire abstract

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2009 Dec;41(12):1018-26. PMID: 20011976

Article Published Date : Dec 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Catechin , Tea

Diseases : Multiple Myeloma

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Chemosensitizer

Additional Keywords : Drug: Bortezomib, Drug Synergy

[+]

The results of the present study indicated that apigenin may be a potentially useful compound for the prevention and treatment of HER2-overexpressing breast cancer.Apr 27, 2015

Click here to read the entire abstract

Pubmed Data : Mol Med Rep. 2015 Apr 28. Epub 2015 Apr 28. PMID: 25936427

Article Published Date : Apr 27, 2015

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Vascular Endothelial Growth Factor Inhibitors

[+]

These findings suggest that mango kernel extract has potential to be developed into a therapeutic mixture for treatment of breast cancers.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2015 ;15:45. Epub 2015 Mar 9. PMID: 25881293

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Mango Seed

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Redox Modulator

Additional Keywords : Dose Response

[+]

These results may suggest that Annona muricata leaf extract had anticancer properties by enhancing caspase-3 activityDec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Gastroenterol Res Pract. 2017 ;2017:4357165. Epub 2017 Apr 9. PMID: 28487731

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Graviola

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation

Additional Keywords : Plant Extracts

[+]

These results reveal that Taiwanofungus salmoneus could be a potential adjuvant chemotherapeutic agent.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Int J Med Mushrooms. 2015 ;17(6):567-77. PMID: 26349514

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Medicinal Mushrooms, Mushrooms: All

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Cell cycle arrest, Chemotherapeutic

Additional Keywords : Drug: Cisplatin, Plant Extracts

Problem Substances : Cisplatin

[+]

This study concludes that shikonin causes apoptosis via a p73-related, caspase-3-dependent pathway.Jul 29, 2015

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2015 Jul 30. Epub 2015 Jul 30. PMID: 26235879

Article Published Date : Jul 29, 2015

Study Type : In Vitro Study

Additional Links

Substances : Shikonin

Diseases : Breast Cancer, Cervical Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Tumor Suppressor Protein p73 Upregulation

[+]

Tualang honey has significant anticancer activity against human breast and cervical cancer cell lines.Mar 31, 2011

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2011 Apr ;49(4):871-8. Epub 2010 Dec 16. PMID: 21167897

Article Published Date : Mar 31, 2011

Study Type : In Vitro Study

Additional Links

Substances : Tualang Honey

Diseases : Breast Cancer, Breast Cancer: Triple Negative , Cervical Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Caspase-9 Activation

[+]

Tulsi extracts can effectively induce apoptosis in prostate cancer cells.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Jul ;18(7):776-85. Epub 2015 Feb 18. PMID: 25692494

Article Published Date : Jun 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Holy Basil

Diseases : Prostate Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation

Additional Keywords : Plant Extracts

[+]

Turmeric oil contains ar-turmerone which displays anti-lymphoma properties.Feb 28, 2009

Click here to read the entire abstract

Pubmed Data : BMB Rep. 2009 Feb 28;42(2):96-100. PMID: 19250610

Article Published Date : Feb 28, 2009

Study Type : In Vitro Study

Additional Links

Substances : Turmeric, Turmerones

Diseases : Lymphoma

Pharmacological Actions : Antioxidants, Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Plant Extracts

[+]

White tea extract induces apoptosis in non-small cell lung cancer cells.Sep 01, 2010

Click here to read the entire abstract

Pubmed Data : Cancer Prev Res (Phila). 2010 Sep;3(9):1132-40. Epub 2010 Jul 28. PMID: 20668019

Article Published Date : Sep 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Catechin , Tea, White Tea

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : 15-Lipoxygenase (15-LOX) Inhibitor, Apoptotic, Caspase-3 Activation, PPAR-Gamma Up-Regulation

Additional Keywords : Plant Extracts

[+]

White tea extract showed high anti-proliferative activity against HT-29 cells, without being toxic to normal fibroblasts.Feb 14, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Chem. 2015 Feb 15 ;169:401-10. Epub 2014 Jul 8. PMID: 25236244

Article Published Date : Feb 14, 2015

Study Type : In Vitro Study

Additional Links

Substances : White Tea

Diseases : Colon Cancer, Colon Cancer: Prevention, DNA damage

Pharmacological Actions : Antioxidant, Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

Additional Keywords : DNA Protective, Plant Extracts

[+]

Xanthohumol induces cell death in human malignant glioblastoma cells. Dec 27, 2011

Click here to read the entire abstract

Pubmed Data : J Nat Prod. 2011 Dec 27 ;74(12):2505-13. Epub 2011 Nov 23. PMID: 22111577

Article Published Date : Dec 27, 2011

Study Type : In Vitro Study

Additional Links

Substances : Xanthohumol

Diseases : Glioblastoma

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

α-tomatine in pure form and in tomatine rich green tomatoes might prevent colon cancer.Jan 22, 2015

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2015 Jan 23. Epub 2015 Jan 23. PMID: 25614934

Article Published Date : Jan 22, 2015

Study Type : In Vitro Study

Additional Links

Substances : Tomato

Diseases : Colon Cancer, Colon Cancer: Prevention

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

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A Nigella sativa extract showed a 88.3% inhibition of proliferation of SiHa human cervical cancer cells and increased the expression of caspase-3, -8 and -9 several-foldJan 31, 2013

Chrysin induces apoptosis of human uveal melanoma cells.Nov 30, 2016

Kahweol inhibits colorectal tumor cell growth by promoting apoptosis and suppressing HSP70 expression.Feb 28, 2015

P. sulcata inhibited the growth in a dose-dependent manner and induced caspase-independent apoptosis at low doses.Apr 30, 2015

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Sanguinarine induces apoptosis of human oral squamous cell carcinoma KB cells.Jul 31, 2016

Tetrahydrocurcumin exhibited significant cell growth inhibition by inducing MCF-7 cells to undergo mitochondrial apoptosis and G2/M arrest.Apr 30, 2014

Zerumbone was able to induce apoptosis of pancreatic carcinoma cell lines Jan 01, 2012

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

An extract of Curcuma purpurascens suppressed the proliferation of HT-29 colon cancer cells and triggered the induction of apoptosis through mitochondrial-dependent pathway.Dec 31, 2014

Baicalein could increase caspase-3 and Bax expression and decrease survivin and Bcl-2 to induce apoptosis.Aug 31, 2017

Berberine activates apoptosis to suppress triple-negative breast cancer cells.Aug 17, 2017

Betanin significantly inhibits lung tumorigenesis in A/J mice and induces apoptosis in lung cancer cells. Aug 31, 2013

Korean Red Ginseng extracts might have the ability to reduce the incidence of leukemia.Sep 30, 2016

Melatonin may delay aging in gastric mucosa tissue by decreasing caspase-3 activity.Mar 14, 2011

Oral administration of apple procyanidins inhibits the proliferation of tumor cells by inducing apoptosis through the intrinsic mitochondrial pathway.Feb 29, 2008

Our results reveal Flavin7 (F7) had substantial tumour-suppression effects of 58 % and reduced tumour incidence by 24 % in this breast cancer model.Apr 30, 2015

Pomegranate fruit juice suppressed androgen dependent prostate carcinogenesis.Oct 03, 2014

The current study clearly indicates that 6-shogaol can be exploited for the prevention and treatment of NSCLC.Feb 28, 2014

The herbal preparation Shemamruthaa had antiproliferative and apoptotic effects on chemically induced breast cancer.Sep 30, 2015

The pro-apoptotic effect of FO in Walker 256 tumor is related with specifics cleaved caspases.Dec 31, 2014

Tocotrienols are potent antitumor agents capable of inducing apoptosis and inhibiting angiogenesis under both hypoxic and normoxic conditions.Jul 31, 2015

Ursolic acid exhibits significant anti-tumor effects by suppressing cell proliferation, promoting apoptosis in gallbladder cancer cells. Dec 31, 2013

A compound within Red Sage (tanshinone) induces programmed cell death in monocyte leukemia cells.Jan 01, 2010

A pinecone water extract induced apoptosis associated with caspase-3 activation in A549, H1264, H1299, and Calu-6 lung cancer cells. Dec 26, 2016

Abrogation of HDGF by EGCG enhances cisplatin-induced apoptosis and sensitizes A549 cells to chemotherapy.Jul 13, 2015

After exposure to different oridonin concentrations, growth rates and cell cycle arrest of BxPC-3 cells were significantly reduced compared with untreated cells.Feb 28, 2015

An anthocyanin-rich dietary bilberry extract induced a redox-sensitive apoptosis in CLL cells with little effect on healthy peripheral blood mononuclear cells.Dec 31, 2014

An apple flavonoid enriched fraction possessed a significantly stronger antiproliferative and specific action than Sorafenib in vitro.Sep 24, 2014

Berbamine exhibited strong anti-prostate cancer activities in vitro and in vivo.Nov 30, 2016

Betaine exhibits tumoricidal effects and acts as a biological response modifier in cancer treatment by inducing apoptosis and cell cycle arrest in a dose and time-dependent manner.Dec 31, 2014

Bisdemethoxycurcumin induced cell apoptosis through multiple signal pathways such as extrinsic, intrinsic and ES tress pathway.Sep 14, 2015

Blackberry Ellagitannins showed anti-cancer activity by arresting the cell cycle and inducing apoptosis on HT-29 human colon cancer cells.May 12, 2015

Cafestol and kahweol are potential cancer treatments, or adjuvants as chemotherapeutic agents for malignant pleural mesothelioma.Jun 25, 2012

Cannabidiol and cannabidiol-dimethylheptyl and exposure of the cells to gamma irradiation markedly enhanced apoptosis, reaching values of 93 and 95%.Sep 30, 2003

Cannabidiol is cytotoxic to human glioma cells. Sep 01, 2006

Carnosic acid induced apoptosis in HCT116 cells via generation of ROS, induction of p53, activation of caspases, and inhibition of STAT3 signaling pathway.Jul 07, 2015

Combined treatment with low doses of γ-tocotrienol and oridonin for 24 h resulted in synergistic inhibition of +SA mammary cancer cells viability.Jun 26, 2015

Crocetin exerts a prominent chemopreventive effect against esophageal cancer through the inhibition of cell proliferation, migration and induction of apoptosis.Feb 28, 2015

Crocin can significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase.Jan 31, 2015

Curcumin can inhibit the proliferation and induce programmed cell death in melanoma cells.Dec 01, 2005

Curcumin could induce apoptosis in pancreatic cancer cells.Sep 30, 2015

Curcumin has the ability to improve the paclitaxel induced apoptosis of HPV positive human cervical cancer cell lines via the NF-κB-p53-caspase-3 pathway.Mar 31, 2015

Curcumin inhibits cell proliferation and promotes apoptosis in osteoclastoma cell through suppression of MMP-9 and NF-κB, and activation JNK signaling pathways.Dec 31, 2014

Curcumin inhibits Ewing sarcoma. Dec 01, 2010

Curcumin is capable of inducing programmed cell death in gastric cancer cells. Nov 01, 2011

Dandelion Root Extract effectively induces apoptosis in highly aggressive and resistant Chronic Myelomonocytic Leukemia (CMML) cell linesJan 01, 2012

Daucus Carota oil extracts inhibited cell proliferation by inducing cell cycle arrest and apoptosis in HT-29 cells.Jan 18, 2015

Demethoxycurcumin may induce apoptosis of skin cancer cells through a caspase dependent pathway.Jun 30, 2017

DHA and EPA are found to exhibit growth-inhibitory effect on the human neuroblastoma LA-N-1 cells.Dec 31, 2014

Fucoidan may be a potential therapeutic reagent against the growth of human colon cancer cells.Aug 31, 2015

Ginkgolide B from ginkgo biloba has an antiproliferative and apoptosis-Inducing effect on ovarian cancer cellsApr 13, 2012

HEABG reduces leukemic cell growth by inducing caspase-dependent apoptosis through both intrinsic and extrinsic pathways.Mar 31, 2014

Hyperoside and rutin from lotus roots may be the promising candidates for treatment of colon cancer.Mar 31, 2016

In the current study we demonstrated that cannabidiol can induce apoptosis in murine as well as human leukemia cells.Aug 31, 2006

Lichen metabolites showed various cytotoxic effects in a concentration-dependent manner against cancer cells. Feb 28, 2013

Lion's mane induces programmed cell death in monocytic leukemia cells. Jun 01, 2011

Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

Melatonin sensitizes the cisplatin-mediated growth suppression of liver cancer cells.Dec 31, 2016

Natural compounds present in oyster mushroom could modulate apoptosis and cell cycle pathways that are frequently blocked in human cancers.Apr 30, 2015

Oridonin effectively inhibited cell proliferation and induced apoptosis in HCT-116 and LoVo cells in a concentration-dependent manner.Apr 30, 2015

P53 and survivin may provide promising targets of docosahexaenoic acid in acute lymphoblastic leukemia cells.Nov 22, 2016

Piperlongumine and alpha lipoic acid may have a potential value as a therapeutic agent for patients with acute promyelocytic leukemia.Mar 31, 2016

Quercetin has promising effects on the inhibition of growth, invasion, and metastatic potential of melanoma.Dec 31, 2015

Resveratraol induces cell death in human ovarian cancer cells. Nov 01, 2010

Resveratrol could suppress hyperplasia of synovial cells, a critical factor of rheumatoid arthritis.Aug 10, 2010

Resveratrol induces programmed cell death and suppressioin of neuroendocrine markers in medullary thyroid cancer.Dec 24, 2010

Resveratrol induces programmed cell death in ovarian cancer cells. Jan 01, 2011

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis.Oct 31, 2009

Shikonin exhibited its anti-tumor activity against HGC-27 cells through inhibiting cell growth and promoting apoptosis by targeting mitochondrial-related signaling pathway.Mar 31, 2015

Snake venom toxins induces mitochondrial and caspase-3 dependent apoptosis in cancer cell lines.Dec 31, 2015

Sulforaphane induces programmed cell death in human cervical and liver cancer cells through activation of caspase-3. Jul 01, 2007

Caspase-3 Activation

View the Evidence:
90 Abstracts with Caspase-3 Activation Research