Caspase-3 Activation

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90 Substances Researched for Caspase-3 Activation
NameACCKFocus
Curcumin711Locked
Bloodroot26Locked
Kahweol26Locked
Lichens26Locked
Tetrahydrocurcumin26Locked
Chrysin15Locked
Curcumin: Degradiation byproducts15Locked
Ginger15Locked
Nigella sativa (aka Black Seed)15Locked
Piperine15Locked
Zerumbone15Locked
Resveratrol44Locked
Berberine23Locked
Betaine 23Locked
Cannabidiol33Locked
Melatonin23Locked
Oridonin33Locked
Ursolic Acid23Locked
6-Shogaol12Locked
Apple12Locked
Baicalein12Locked
Beet12Locked
Catechin 22Locked
Curcuma Purpurascens 12Locked
DHA (Docosahexaenoic Acid)22Locked
Ellagic Acid12Locked
Fish Oil12Locked
Flavonoids22Locked
Fruit Peel12Locked
Ginseng (Korean)12Locked
Mushrooms: All 22Locked
Polyphenols12Locked
Polyunsaturated Fatty Acids (PUFAs)12Locked
Pomegranate12Locked
Shemamruthaa12Locked
Shiitake Mushroom 12Locked
Shikonin22Locked
Tea22Locked
Tocotrienol: Delta12Locked
Vitamin E12Locked
White Tea22Locked
Alpha-Lipoic Acid11Locked
Apigenin11Locked
Apple Polyphenols11Locked
Berbamine11Locked
Bilberry11Locked
Bisdemethoxycurcumin11Locked
Blackberry11Locked
Cafestol11Locked
Cannabinoids 11Locked
Carnosic Acid11Locked
Carrot11Locked
Crocetin11Locked
Crocin11Locked
D-Limonene11Locked
Dandelion 11Locked
Demethoxycurcumin11Locked
EPA (Eicosapentaenoic Acid)11Locked
Fucoidan11Locked
Garlic: Aged11Locked
Ginkgo biloba11Locked
Graviola 11Locked
Hawthorn11Locked
Holy Basil11Locked
Lion's Mane (Hericium Erinaceus)11Locked
Lithospermum erythrorhizon11Locked
Long Pepper11Locked
Lotus 11Locked
Mango Seed11Locked
Medicinal Mushrooms11Locked
Naringenin 11Locked
Nobiletin 11Locked
Oyster Mushroom11Locked
Pine Cone11Locked
Piperlongumine 11Locked
Quercetin11Locked
Red Sage11Locked
Rosemary11Locked
Rutin11Locked
Sulforaphane11Locked
Tangeretin 11Locked
Tocotrienol: Gamma11Locked
Tomato11Locked
Tualang Honey11Locked
Turmeric11Locked
Turmerones11Locked
Venom: Snake11Locked
Vitamin D11Locked
Vitamin E: Gamma-tocotrienol11Locked
Xanthohumol11Locked

View the Evidence:
90 Abstracts with Caspase-3 Activation Research

[+]

A Nigella sativa extract showed a 88.3% inhibition of proliferation of SiHa human cervical cancer cells and increased the expression of caspase-3, -8 and -9 several-foldJan 31, 2013

Pubmed Data : Nat Prod Commun. 2013 Feb ;8(2):213-6. PMID: 23513732
Article Published Date : Jan 31, 2013
Study Type : Human In Vitro
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Plant Extracts
[+]

Chrysin induces apoptosis of human uveal melanoma cells.Nov 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Dec ;12(6):4813-4820. Epub 2016 Oct 13. PMID: 28105189
Article Published Date : Nov 30, 2016
Study Type : Human In Vitro
Additional Links
Substances : Chrysin
Diseases : Melanoma: Uveal
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation
[+]

Kahweol inhibits colorectal tumor cell growth by promoting apoptosis and suppressing HSP70 expression.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 Mar ;23(2):128-33. Epub 2015 Mar 1. PMID: 25767680
Article Published Date : Feb 28, 2015
Study Type : Human In Vitro
Additional Links
Substances : Kahweol
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Heat Shock Protein Down-Regulation
[+]

P. sulcata inhibited the growth in a dose-dependent manner and induced caspase-independent apoptosis at low doses.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cytotechnology. 2015 May ;67(3):531-43. Epub 2014 Mar 28. PMID: 24676908
Article Published Date : Apr 30, 2015
Study Type : Human In Vitro
Additional Links
Substances : Lichens
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Caspase-3 Activation
Additional Keywords : Apoptotic, Breast Cancer, Breast Cancer: Triple Negative, Caspase-3 Activation, Dose Response, Lichens
[+]

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Pubmed Data : Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID: 24272201
Article Published Date : Mar 31, 2014
Study Type : Human In Vitro
Additional Links
Substances : Piperine
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Selective Cytotoxicity
[+]

Sanguinarine induces apoptosis of human oral squamous cell carcinoma KB cells.Jul 31, 2016

Pubmed Data : Drug Dev Res. 2016 Aug ;77(5):227-40. Epub 2016 Jul 1. PMID: 27363951
Article Published Date : Jul 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Bloodroot
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation
[+]

Tetrahydrocurcumin exhibited significant cell growth inhibition by inducing MCF-7 cells to undergo mitochondrial apoptosis and G2/M arrest.Apr 30, 2014

Pubmed Data : Food Chem Toxicol. 2014 May ;67:193-200. Epub 2014 Mar 1. PMID: 24593988
Article Published Date : Apr 30, 2014
Study Type : Human In Vitro
Additional Links
Substances : Curcumin: Degradiation byproducts, Tetrahydrocurcumin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Cell cycle arrest, P21 Activation
[+]

Zerumbone was able to induce apoptosis of pancreatic carcinoma cell lines Jan 01, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:936030. Epub 2012 Jan 29. PMID: 22454691
Article Published Date : Jan 01, 2012
Study Type : Human In Vitro
Additional Links
Substances : Ginger, Zerumbone
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, P21 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Zerumbone
[+]

A water-extracted polysaccharide from Lentinus edodes exerts direct antitumor effects by inducing apoptosis in colon cancer cells.Nov 20, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27888812
Article Published Date : Nov 20, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, NF-kappaB Inhibitor
Additional Keywords : Polysaccharides
[+]

An extract of Curcuma purpurascens suppressed the proliferation of HT-29 colon cancer cells and triggered the induction of apoptosis through mitochondrial-dependent pathway.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 ;15:15. Epub 2015 Feb 5. PMID: 25652758
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcuma Purpurascens
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation
Additional Keywords : Dose Response
[+]

Baicalein could increase caspase-3 and Bax expression and decrease survivin and Bcl-2 to induce apoptosis.Aug 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pancreas. 2017 Sep ;46(8):1076-1081. PMID: 28787336
Article Published Date : Aug 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Survivin Down-Regulation
[+]

Berberine activates apoptosis to suppress triple-negative breast cancer cells.Aug 17, 2017

Pubmed Data : Biomed Pharmacother. 2017 Aug 18 ;95:18-24. Epub 2017 Aug 18. PMID: 28826092
Article Published Date : Aug 17, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation
[+]

Betanin significantly inhibits lung tumorigenesis in A/J mice and induces apoptosis in lung cancer cells. Aug 31, 2013

Pubmed Data : Mol Carcinog. 2013 Sep ;52(9):686-91. Epub 2012 Mar 27. PMID: 22456940
Article Published Date : Aug 31, 2013
Study Type : Animal Study
Additional Links
Substances : Beet, Betaine
Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anticarcinogenic Agents, Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Caspase-9 Activation, Chemopreventive
Additional Keywords : Beet, Benzo(a)pyrene, Betaine, lung cancer, Vinyl Carbamate
Problem Substances : Benzo(a)pyrene, Vinyl Carbamate
[+]

Korean Red Ginseng extracts might have the ability to reduce the incidence of leukemia.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2016 Oct ;40(4):431-436. Epub 2016 Aug 4. PMID: 27746697
Article Published Date : Sep 30, 2016
Study Type : Animal Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Lymphoma
Pharmacological Actions : Anti-metastatic, Apoptotic, Caspase-3 Activation, Caspase-8 activation, Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords : Plant Extracts
[+]

Melatonin may delay aging in gastric mucosa tissue by decreasing caspase-3 activity.Mar 14, 2011

Pubmed Data : Aging Clin Exp Res. 2011 Mar 14. Epub 2011 Mar 14. PMID: 21406955
Article Published Date : Mar 14, 2011
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Aging
Pharmacological Actions : Anti-Apoptotic, Caspase-3 Activation
[+]

Oral administration of apple procyanidins inhibits the proliferation of tumor cells by inducing apoptosis through the intrinsic mitochondrial pathway.Feb 29, 2008

Pubmed Data : Carcinogenesis. 2008 Mar ;29(3):585-93. Epub 2007 Sep 7. PMID: 17827407
Article Published Date : Feb 29, 2008
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Apple
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation
Additional Keywords : Proanthocyanidins
[+]

Our results reveal Flavin7 (F7) had substantial tumour-suppression effects of 58 % and reduced tumour incidence by 24 % in this breast cancer model.Apr 30, 2015

Pubmed Data : Eur J Nutr. 2015 May 1. Epub 2015 May 1. PMID: 25930965
Article Published Date : Apr 30, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fruit Peel, Polyphenols
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Bax/Bcl2 Ratio: Decrease, Caspase-3 Activation, Cell cycle arrest, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Dose Response, Plant Extracts
[+]

Pomegranate fruit juice suppressed androgen dependent prostate carcinogenesis.Oct 03, 2014

Pubmed Data : Prostate. 2014 Oct 4. Epub 2014 Oct 4. PMID: 25284475
Article Published Date : Oct 03, 2014
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Pomegranate
Diseases : Cancer: Prostate, Prostate Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, Chemopreventive
[+]

The current study clearly indicates that 6-shogaol can be exploited for the prevention and treatment of NSCLC.Feb 28, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2014 Mar ;35(3):683-91. Epub 2013 Nov 26. PMID: 24282290
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer: Prevention
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest, Chemopreventive, STAT3 Inhibitor
[+]

The herbal preparation Shemamruthaa had antiproliferative and apoptotic effects on chemically induced breast cancer.Sep 30, 2015

Pubmed Data : J Evid Based Complementary Altern Med. 2015 Oct ;20(4):259-68. Epub 2015 Apr 17. PMID: 25888591
Article Published Date : Sep 30, 2015
Study Type : Animal Study
Additional Links
Substances : Shemamruthaa
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

The pro-apoptotic effect of FO in Walker 256 tumor is related with specifics cleaved caspases.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lipids Health Dis. 2015 ;14(1):94. Epub 2015 Aug 25. PMID: 26303118
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Fish Oil, Polyunsaturated Fatty Acids (PUFAs)
Diseases : Tumors
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Tumor Suppressor Protein p53 Upregulation
[+]

Tocotrienols are potent antitumor agents capable of inducing apoptosis and inhibiting angiogenesis under both hypoxic and normoxic conditions.Jul 31, 2015

Pubmed Data : J Nutr Biochem. 2015 Aug ;26(8):832-40. Epub 2015 Apr 14. PMID: 25979648
Article Published Date : Jul 31, 2015
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Delta, Vitamin E
Diseases : Colorectal Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, P21 Activation
Additional Keywords : Dose Response
[+]

Ursolic acid exhibits significant anti-tumor effects by suppressing cell proliferation, promoting apoptosis in gallbladder cancer cells. Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2014 ;14(1):96. Epub 2014 Oct 29. PMID: 25383044
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Gallbladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest
Additional Keywords : Dose Response
[+]

A compound within Red Sage (tanshinone) induces programmed cell death in monocyte leukemia cells.Jan 01, 2010

Pubmed Data : Int J Mol Sci. 2010;11(6):2267-80. Epub 2010 May 26. PMID: 20640151
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Red Sage
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Telomerase Inhibitor
[+]

A pinecone water extract induced apoptosis associated with caspase-3 activation in A549, H1264, H1299, and Calu-6 lung cancer cells. Dec 26, 2016

Pubmed Data : Chem Biodivers. 2016 Dec 27. Epub 2016 Dec 27. PMID: 28027428
Article Published Date : Dec 26, 2016
Study Type : In Vitro Study
Additional Links
Substances : Pine Cone
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation
[+]

Abrogation of HDGF by EGCG enhances cisplatin-induced apoptosis and sensitizes A549 cells to chemotherapy.Jul 13, 2015

Pubmed Data : Proteomics Clin Appl. 2015 Jul 14. Epub 2015 Jul 14. PMID: 26175166
Article Published Date : Jul 13, 2015
Study Type : In Vitro Study
Additional Links
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Chemosensitizer
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

After exposure to different oridonin concentrations, growth rates and cell cycle arrest of BxPC-3 cells were significantly reduced compared with untreated cells.Feb 28, 2015

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2015 Mar ;47(3):164-73. Epub 2015 Feb 3. PMID: 25651847
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Cell cycle arrest
[+]

An anthocyanin-rich dietary bilberry extract induced a redox-sensitive apoptosis in CLL cells with little effect on healthy peripheral blood mononuclear cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2015 ;5:8996. Epub 2015 Mar 11. PMID: 25757575
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bilberry
Diseases : Chronic Lymphocytic Leukemia
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemotherapeutic
Additional Keywords : Plant Extracts, Selective Cytotoxicity
[+]

An apple flavonoid enriched fraction possessed a significantly stronger antiproliferative and specific action than Sorafenib in vitro.Sep 24, 2014

Pubmed Data : Nutr Cancer. 2014 Sep 25:1-10. Epub 2014 Sep 25. PMID: 25256427
Article Published Date : Sep 24, 2014
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols, Flavonoids
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest, Chemopreventive, Topoisomerase II Inhibitor
Additional Keywords : Northern Spy Apples, Plant Extracts, Selective Cytotoxicity
[+]

Berbamine exhibited strong anti-prostate cancer activities in vitro and in vivo.Nov 30, 2016

Pubmed Data : Prostate Cancer Prostatic Dis. 2016 Dec ;19(4):358-366. Epub 2016 Jul 19. PMID: 27431500
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Berbamine
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation
Additional Keywords : Dose Response
[+]

Betaine exhibits tumoricidal effects and acts as a biological response modifier in cancer treatment by inducing apoptosis and cell cycle arrest in a dose and time-dependent manner.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(8):3195-201. PMID: 25921120
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Betaine
Diseases : Cervical Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest
Additional Keywords : Dose Response, Higher Dose Better Than Lower Dose
[+]

Bisdemethoxycurcumin induced cell apoptosis through multiple signal pathways such as extrinsic, intrinsic and ES tress pathway.Sep 14, 2015

Pubmed Data : Environ Toxicol. 2015 Sep 15. Epub 2015 Sep 15. PMID: 26370218
Article Published Date : Sep 14, 2015
Study Type : In Vitro Study
Additional Links
Substances : Bisdemethoxycurcumin
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Cell cycle arrest
[+]

Blackberry Ellagitannins showed anti-cancer activity by arresting the cell cycle and inducing apoptosis on HT-29 human colon cancer cells.May 12, 2015

Pubmed Data : Food Funct. 2015 May 13 ;6(5):1675-83. PMID: 25906041
Article Published Date : May 12, 2015
Study Type : In Vitro Study
Additional Links
Substances : Blackberry
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemopreventive, P21 Activation
[+]

Cafestol and kahweol are potential cancer treatments, or adjuvants as chemotherapeutic agents for malignant pleural mesothelioma.Jun 25, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Sci. 2012 Jun 26 ;19:60. Epub 2012 Jun 26. PMID: 22734486
Article Published Date : Jun 25, 2012
Study Type : In Vitro Study
Additional Links
Substances : Cafestol, Kahweol
Diseases : Mesothelioma
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemotherapeutic
[+]

Cannabidiol and cannabidiol-dimethylheptyl and exposure of the cells to gamma irradiation markedly enhanced apoptosis, reaching values of 93 and 95%.Sep 30, 2003

Pubmed Data : Leuk Lymphoma. 2003 Oct ;44(10):1767-73. PMID: 14692532
Article Published Date : Sep 30, 2003
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol, Cannabinoids
Diseases : Acute Myeloid Leukemia
Pharmacological Actions : Apoptotic, Caspase-3 Activation
Additional Keywords : Dose Response, Gamma Irradiation, Radiation Synergy
[+]

Cannabidiol is cytotoxic to human glioma cells. Sep 01, 2006

Pubmed Data : Cell Mol Life Sci. 2006 Sep;63(17):2057-66. PMID: 16909207
Article Published Date : Sep 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Glioma
Pharmacological Actions : Anti-Proliferative, Caspase-3 Activation
[+]

Carnosic acid induced apoptosis in HCT116 cells via generation of ROS, induction of p53, activation of caspases, and inhibition of STAT3 signaling pathway.Jul 07, 2015

Pubmed Data : Mol Carcinog. 2015 Jul 8. Epub 2015 Jul 8. PMID: 26152521
Article Published Date : Jul 07, 2015
Study Type : In Vitro Study
Additional Links
Substances : Carnosic Acid, Rosemary
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, STAT3 Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Combined treatment with low doses of γ-tocotrienol and oridonin for 24 h resulted in synergistic inhibition of +SA mammary cancer cells viability.Jun 26, 2015

Pubmed Data : Mol Cell Biochem. 2015 Jun 27. Epub 2015 Jun 27. PMID: 26112904
Article Published Date : Jun 26, 2015
Study Type : In Vitro Study
Additional Links
Substances : Oridonin, Tocotrienol: Gamma
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Caspase-3 Activation
Additional Keywords : Natural Substance Synergy, Selective Antiproliferation, Selective Cytotoxicity
[+]

Crocetin exerts a prominent chemopreventive effect against esophageal cancer through the inhibition of cell proliferation, migration and induction of apoptosis.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2015 Mar ;9(3):1254-1260. Epub 2015 Jan 13. PMID: 25663893
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Caspase-3 Activation, Chemopreventive
[+]

Crocin can significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase.Jan 31, 2015

Pubmed Data : Nat Prod Commun. 2015 Feb ;10(2):249-52. PMID: 25920253
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumin can inhibit the proliferation and induce programmed cell death in melanoma cells.Dec 01, 2005

Pubmed Data : Di Yi Jun Yi Da Xue Xue Bao. 2005 Dec;25(12):1517-21. PMID: 16361152
Article Published Date : Dec 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation
[+]

Curcumin could induce apoptosis in pancreatic cancer cells.Sep 30, 2015

Pubmed Data : Mol Med Rep. 2015 Oct ;12(4):5415-22. Epub 2015 Jul 8. PMID: 26166196
Article Published Date : Sep 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 Ratio: Decrease, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest
[+]

Curcumin has the ability to improve the paclitaxel induced apoptosis of HPV positive human cervical cancer cell lines via the NF-κB-p53-caspase-3 pathway.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2015 Apr ;9(4):1470-1476. Epub 2015 Jan 29. PMID: 25780454
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cervical Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemothapeutic Synergy: Paclitaxel
[+]

Curcumin inhibits cell proliferation and promotes apoptosis in osteoclastoma cell through suppression of MMP-9 and NF-κB, and activation JNK signaling pathways.Dec 31, 2014

Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(6):6037-45. Epub 2015 Jun 1. PMID: 26261481
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Osteoclastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Curcumin inhibits Ewing sarcoma. Dec 01, 2010

Pubmed Data : Med Oncol. 2010 Dec;27(4):1096-101. Epub 2009 Oct 27. PMID: 19859844
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Sarcoma: Ewing's
Pharmacological Actions : Caspase-3 Activation, Chemopreventive
[+]

Curcumin is capable of inducing programmed cell death in gastric cancer cells. Nov 01, 2011

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov ;27(11):1227-30. PMID: 22078453
Article Published Date : Nov 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation
[+]

Dandelion Root Extract effectively induces apoptosis in highly aggressive and resistant Chronic Myelomonocytic Leukemia (CMML) cell linesJan 01, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2012 ;7(2):e30604. Epub 2012 Feb 17. PMID: 22363452
Article Published Date : Jan 01, 2012
Study Type : In Vitro Study
Additional Links
Substances : Dandelion
Diseases : Leukemia, Leukemia: Multi-Drug Resistant
Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Caspase-3 Activation, Caspase-8 activation
Additional Keywords : Chronic Myelomonocytic Leukemia, Dose Response, Selective Cytotoxicity
[+]

Daucus Carota oil extracts inhibited cell proliferation by inducing cell cycle arrest and apoptosis in HT-29 cells.Jan 18, 2015

Pubmed Data : J Med Food. 2015 Jan 19. Epub 2015 Jan 19. PMID: 25599142
Article Published Date : Jan 18, 2015
Study Type : In Vitro Study
Additional Links
Substances : Carrot
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Cell cycle arrest, PI3K/Akt/signaling suppression
Additional Keywords : Plant Extracts
[+]

Demethoxycurcumin may induce apoptosis of skin cancer cells through a caspase dependent pathway.Jun 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Jul ;16(1):539-546. Epub 2017 May 31. PMID: 28586041
Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Demethoxycurcumin
Diseases : Skin Cancer: Squamous Cell
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation
[+]

DHA and EPA are found to exhibit growth-inhibitory effect on the human neuroblastoma LA-N-1 cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2015 ;7(8):6956-73. Epub 2015 Aug 18. PMID: 26295255
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid)
Diseases : Neuroblastoma
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest
[+]

Fucoidan may be a potential therapeutic reagent against the growth of human colon cancer cells.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Sep ;12(3):3446-52. Epub 2015 May 21. PMID: 25998232
Article Published Date : Aug 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Caspase-3 Activation
[+]

Ginkgolide B from ginkgo biloba has an antiproliferative and apoptosis-Inducing effect on ovarian cancer cellsApr 13, 2012

Pubmed Data : Integr Cancer Ther. 2012 Apr 13. Epub 2012 Apr 13. PMID: 22505596
Article Published Date : Apr 13, 2012
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Chemosensitizer, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
Problem Substances : Cisplatin
[+]

HEABG reduces leukemic cell growth by inducing caspase-dependent apoptosis through both intrinsic and extrinsic pathways.Mar 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2014 Apr ;8(2):132-7. Epub 2014 Mar 28. PMID: 24741395
Article Published Date : Mar 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Garlic: Aged
Diseases : Leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation
[+]

Hyperoside and rutin from lotus roots may be the promising candidates for treatment of colon cancer.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Apr ;11(4):2463-2470. Epub 2016 Feb 18. PMID: 27073499
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lotus , Rutin
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation
[+]

In the current study we demonstrated that cannabidiol can induce apoptosis in murine as well as human leukemia cells.Aug 31, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Pharmacol. 2006 Sep ;70(3):897-908. Epub 2006 Jun 5. PMID: 16754784
Article Published Date : Aug 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, NADPH Oxidase Inhibitors
Additional Keywords : Cannabinoid Receptors
[+]

Lichen metabolites showed various cytotoxic effects in a concentration-dependent manner against cancer cells. Feb 28, 2013

Pubmed Data : Phytother Res. 2013 Mar ;27(3):431-7. Epub 2012 May 25. PMID: 22628260
Article Published Date : Feb 28, 2013
Study Type : In Vitro Study
Additional Links
Substances : Lichens
Diseases : Breast Cancer, Cervical Cancer, Colon Cancer, Oxidative Stress
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation
Additional Keywords : Dose Response, Metabolites
[+]

Lion's mane induces programmed cell death in monocytic leukemia cells. Jun 01, 2011

Pubmed Data : Food Funct. 2011 Jun ;2(6):348-56. Epub 2011 Jun 8. PMID: 21779573
Article Published Date : Jun 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Infant Acute Monocytic Leukemia, Leukemia: Monocytic
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation
[+]

Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

Pubmed Data : Food Chem Toxicol. 2017 Feb ;100:149-160. Epub 2016 Dec 23. PMID: 28025124
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Ursolic Acid
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Antiproliferative, Breast Cancer: Triple Negative, Dose Response, Hawthorn, Ursolic Acid
[+]

Melatonin sensitizes the cisplatin-mediated growth suppression of liver cancer cells.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cancer Res. 2017 ;7(1):13-27. Epub 2017 Jan 1. PMID: 28123844
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Melatonin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Chemosensitizer, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Natural compounds present in oyster mushroom could modulate apoptosis and cell cycle pathways that are frequently blocked in human cancers.Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Iran Med. 2015 May ;18(5):284-95. PMID: 25959910
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Mushrooms: All , Oyster Mushroom
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, P21 Activation
[+]

Oridonin effectively inhibited cell proliferation and induced apoptosis in HCT-116 and LoVo cells in a concentration-dependent manner.Apr 30, 2015

Pubmed Data : Biomed Pharmacother. 2015 May ;72:125-34. Epub 2015 Apr 27. PMID: 26054686
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, MicroRNA modulator
Additional Keywords : Dose Response
[+]

P53 and survivin may provide promising targets of docosahexaenoic acid in acute lymphoblastic leukemia cells.Nov 22, 2016

Pubmed Data : Nutr Cancer. 2016 Nov 23:1-10. Epub 2016 Nov 23. PMID: 27880058
Article Published Date : Nov 22, 2016
Study Type : In Vitro Study
Additional Links
Substances : DHA (Docosahexaenoic Acid)
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Survivin Down-Regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Piperlongumine and alpha lipoic acid may have a potential value as a therapeutic agent for patients with acute promyelocytic leukemia.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Res Ther. 2016 Apr-Jun;12(2):556-60. PMID: 27461609
Article Published Date : Mar 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Alpha-Lipoic Acid, Long Pepper, Piperlongumine
Diseases : Leukemia, Leukemia: Acute promyelocytic leukemia
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemotherapeutic, Cyclooxygenase 2 Inhibitors
Additional Keywords : Natural Substance Synergy
[+]

Quercetin has promising effects on the inhibition of growth, invasion, and metastatic potential of melanoma.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2016 ;9:6445-6459. Epub 2016 Aug 19. PMID: 27799792
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Melanoma
Pharmacological Actions : Anti-metastatic, Apoptotic, Caspase-3 Activation, Chemopreventive
[+]

Resveratraol induces cell death in human ovarian cancer cells. Nov 01, 2010

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2010 Nov;30(11):2440-2. PMID: 21097399
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation
[+]

Resveratrol could suppress hyperplasia of synovial cells, a critical factor of rheumatoid arthritis.Aug 10, 2010

Pubmed Data : Rheumatol Int. 2010 Aug 10. Epub 2010 Aug 10. PMID: 20697895
Article Published Date : Aug 10, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Arthritis: Rheumatoid
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Caspase-3 Activation, Caspase-9 Activation
[+]

Resveratrol induces programmed cell death and suppressioin of neuroendocrine markers in medullary thyroid cancer.Dec 24, 2010

Pubmed Data : Ann Surg Oncol. 2010 Dec 24. Epub 2010 Dec 24. PMID: 21184191
Article Published Date : Dec 24, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Thyroid Cancer
Pharmacological Actions : Anti-Proliferative, Apoptotic, Caspase-3 Activation
[+]

Resveratrol induces programmed cell death in ovarian cancer cells. Jan 01, 2011

Pubmed Data : J Med Food. 2011 Jan-Feb;14(1-2):46-52. Epub 2010 Dec 27. PMID: 21186985
Article Published Date : Jan 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Ovarian Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation
[+]

Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis.Oct 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anticancer Res. 2009 Nov ;29(11):4457-65. PMID: 20032392
Article Published Date : Oct 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Bloodroot
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemosensitizer
Additional Keywords : Apoptotic, Bloodroot, Caspase-3 Activation, Chemosensitizer, gastric cancer
[+]

Shikonin exhibited its anti-tumor activity against HGC-27 cells through inhibiting cell growth and promoting apoptosis by targeting mitochondrial-related signaling pathway.Mar 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2015 Apr-Jun;11(42):250-6. PMID: 25829762
Article Published Date : Mar 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lithospermum erythrorhizon, Shikonin
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation
[+]

Snake venom toxins induces mitochondrial and caspase-3 dependent apoptosis in cancer cell lines.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Pharm Res. 2016 ;15(Suppl):101-112. PMID: 28228809
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Venom: Snake
Diseases : Breast Cancer, Liver Cancer, Prostate Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation
[+]

Sulforaphane induces programmed cell death in human cervical and liver cancer cells through activation of caspase-3. Jul 01, 2007

Pubmed Data : Oncol Rep. 2007 Jul;18(1):181-7. PMID: 17549366
Article Published Date : Jul 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cervical Cancer, Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Caspase-3 Activation
[+]

Tangeretin was found to be a multidrug resistance modulator in resistant cells by sensitizing them to doxorubicin.Nov 25, 2012

Pubmed Data : J Nat Prod. 2012 Nov 26 ;75(11):1896-902. Epub 2012 Nov 8. PMID: 23137376
Article Published Date : Nov 25, 2012
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Naringenin , Nobiletin , Tangeretin
Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Colon Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Chemosensitizer, Chemotherapeutic
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Tetrahydrocurcumin is more effective than curcumin in inducing the apoptosis of H22 cells.Aug 01, 2017

Pubmed Data : Food Funct. 2017 Aug 2. Epub 2017 Aug 2. PMID: 28766664
Article Published Date : Aug 01, 2017
Study Type : In Vitro Study
Additional Links
Substances : Tetrahydrocurcumin
Diseases : Liver Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation
[+]

The combination of berberine and d-limonene exerted synergistic anticancer effects on MGC803 cells by cell-cycle arrest, ROS production, and apoptosis induction.Aug 31, 2014

Pubmed Data : J Med Food. 2014 Sep ;17(9):955-62. Epub 2014 Jul 21. PMID: 25045784
Article Published Date : Aug 31, 2014
Study Type : Plant Study
Additional Links
Substances : Berberine, D-Limonene
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation
Additional Keywords : Dose Response, Natural Substance Synergy, Plant Extracts
[+]

The combined use of 1,25(OH)2D3 and cisplatin may be used as a strategy to overcome resistance to cisplatin and dose limitations, and to improve the anticancer effects of chemotherapy.Apr 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2014 May ;33(5):1177-84. Epub 2014 Feb 24. PMID: 24573222
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Vitamin D
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Cell cycle arrest
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

The green tea polyphenol EGCG enhances the anti-cancer activity of bortezomib in multiple myeloma cells. Dec 01, 2009

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2009 Dec;41(12):1018-26. PMID: 20011976
Article Published Date : Dec 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Tea
Diseases : Multiple Myeloma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Chemosensitizer
Additional Keywords : Drug: Bortezomib, Drug Synergy
[+]

The results of the present study indicated that apigenin may be a potentially useful compound for the prevention and treatment of HER2-overexpressing breast cancer.Apr 27, 2015

Pubmed Data : Mol Med Rep. 2015 Apr 28. Epub 2015 Apr 28. PMID: 25936427
Article Published Date : Apr 27, 2015
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Vascular Endothelial Growth Factor Inhibitors
[+]

These findings suggest that mango kernel extract has potential to be developed into a therapeutic mixture for treatment of breast cancers.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2015 ;15:45. Epub 2015 Mar 9. PMID: 25881293
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Mango Seed
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Redox Modulator
Additional Keywords : Dose Response
[+]

These results may suggest that Annona muricata leaf extract had anticancer properties by enhancing caspase-3 activityDec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gastroenterol Res Pract. 2017 ;2017:4357165. Epub 2017 Apr 9. PMID: 28487731
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Graviola
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation
Additional Keywords : Plant Extracts
[+]

These results reveal that Taiwanofungus salmoneus could be a potential adjuvant chemotherapeutic agent.Dec 31, 2014

Pubmed Data : Int J Med Mushrooms. 2015 ;17(6):567-77. PMID: 26349514
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Medicinal Mushrooms, Mushrooms: All
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Cell cycle arrest, Chemotherapeutic
Additional Keywords : Drug: Cisplatin, Plant Extracts
Problem Substances : Cisplatin
[+]

This study concludes that shikonin causes apoptosis via a p73-related, caspase-3-dependent pathway.Jul 29, 2015

Pubmed Data : Biochem Biophys Res Commun. 2015 Jul 30. Epub 2015 Jul 30. PMID: 26235879
Article Published Date : Jul 29, 2015
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Breast Cancer, Cervical Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Tumor Suppressor Protein p73 Upregulation
[+]

Tualang honey has significant anticancer activity against human breast and cervical cancer cell lines.Mar 31, 2011

Pubmed Data : Food Chem Toxicol. 2011 Apr ;49(4):871-8. Epub 2010 Dec 16. PMID: 21167897
Article Published Date : Mar 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Tualang Honey
Diseases : Breast Cancer, Breast Cancer: Triple Negative , Cervical Cancer
Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Caspase-9 Activation
[+]

Tulsi extracts can effectively induce apoptosis in prostate cancer cells.Jun 30, 2015

Pubmed Data : J Med Food. 2015 Jul ;18(7):776-85. Epub 2015 Feb 18. PMID: 25692494
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Holy Basil
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation
Additional Keywords : Plant Extracts
[+]

Turmeric oil contains ar-turmerone which displays anti-lymphoma properties.Feb 28, 2009

Pubmed Data : BMB Rep. 2009 Feb 28;42(2):96-100. PMID: 19250610
Article Published Date : Feb 28, 2009
Study Type : In Vitro Study
Additional Links
Substances : Turmeric, Turmerones
Diseases : Lymphoma
Pharmacological Actions : Antioxidants, Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Plant Extracts
[+]

White tea extract induces apoptosis in non-small cell lung cancer cells.Sep 01, 2010

Pubmed Data : Cancer Prev Res (Phila). 2010 Sep;3(9):1132-40. Epub 2010 Jul 28. PMID: 20668019
Article Published Date : Sep 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Tea, White Tea
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : 15-Lipoxygenase (15-LOX) Inhibitor, Apoptotic, Caspase-3 Activation, PPAR-Gamma Up-Regulation
Additional Keywords : Plant Extracts
[+]

White tea extract showed high anti-proliferative activity against HT-29 cells, without being toxic to normal fibroblasts.Feb 14, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Chem. 2015 Feb 15 ;169:401-10. Epub 2014 Jul 8. PMID: 25236244
Article Published Date : Feb 14, 2015
Study Type : In Vitro Study
Additional Links
Substances : White Tea
Diseases : Colon Cancer, Colon Cancer: Prevention, DNA damage
Pharmacological Actions : Antioxidant, Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation
Additional Keywords : DNA Protective, Plant Extracts
[+]

Xanthohumol induces cell death in human malignant glioblastoma cells. Dec 27, 2011

Pubmed Data : J Nat Prod. 2011 Dec 27 ;74(12):2505-13. Epub 2011 Nov 23. PMID: 22111577
Article Published Date : Dec 27, 2011
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Glioblastoma
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Caspase-3 Activation, Caspase-9 Activation
[+]

α-tomatine in pure form and in tomatine rich green tomatoes might prevent colon cancer.Jan 22, 2015

Pubmed Data : J Agric Food Chem. 2015 Jan 23. Epub 2015 Jan 23. PMID: 25614934
Article Published Date : Jan 22, 2015
Study Type : In Vitro Study
Additional Links
Substances : Tomato
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation
[+]

γ-Tocotrienol inhibited cell proliferation and induced a paraptosis-like cell death in human colon cancer cell and may be a potential treatment to prevent and treat apoptosis-resistance colon cancer.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(2):e57779. Epub 2013 Feb 28. PMID: 23469066
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Vitamin E: Gamma-tocotrienol
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Antiproliferative , Caspase-3 Activation, Paraptosis, Wnt/β-catenin pathway down-regulation
Additional Keywords : Dose Response, Treatment Resistant

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