Caspase-9 Activation

Name	AC	CK
Bloodroot	1	5
Chrysin	1	5
Nigella sativa (aka Black Seed)	1	5
Piperine	1	5
Resveratrol	3	3
Ursolic Acid	2	3
Apple	1	2
Beet	1	2
Berberine	1	2
Betaine	1	2
Curcuma Purpurascens	1	2
Lichens	2	2
Mistletoe	1	2
Mushrooms: All	2	2
Shemamruthaa	1	2
Tocotrienol: Delta	1	2
Vitamin E	1	2
Anthocyanins	1	1
Avocado	1	1
Bisdemethoxycurcumin	1	1
Blueberry	1	1
Cannabidiol	1	1
Carnosic Acid	1	1
Catechin	1	1
Chickpea	1	1
Cucurbitacin E	1	1
Curcumin	1	1
DHA (Docosahexaenoic Acid)	1	1
Demethoxycurcumin	1	1
EPA (Eicosapentaenoic Acid)	1	1
Gold (nanoparticles)	1	1
Hawthorn	1	1
Holy Basil	1	1
Isoflavones	1	1
Lion's Mane (Hericium Erinaceus)	1	1
Lithospermum erythrorhizon	1	1
Lotus	1	1
Mango Seed	1	1
Medicinal Mushrooms	1	1
Melatonin	1	1
Moringa oleifera	1	1
Oridonin	1	1
Oyster Mushroom	1	1
Rosemary	1	1
Rutin	1	1
Shikonin	1	1
Tea	1	1
Tetrahydrocurcumin	1	1
Tomato	1	1
Tualang Honey	1	1
White Mulberry	1	1
White Tea	1	1
Xanthohumol	1	1

[+]

Chrysin induces apoptosis of human uveal melanoma cells.Nov 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2016 Dec ;12(6):4813-4820. Epub 2016 Oct 13. PMID: 28105189

Article Published Date : Nov 30, 2016

Study Type : Human In Vitro

Additional Links

Substances : Chrysin

Diseases : Melanoma: Uveal

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID: 24272201

Article Published Date : Mar 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Piperine

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Selective Cytotoxicity

[+]

Sanguinarine induces apoptosis of human oral squamous cell carcinoma KB cells.Jul 31, 2016

Click here to read the entire abstract

Pubmed Data : Drug Dev Res. 2016 Aug ;77(5):227-40. Epub 2016 Jul 1. PMID: 27363951

Article Published Date : Jul 31, 2016

Study Type : Human In Vitro

Additional Links

Substances : Bloodroot

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

An extract of Curcuma purpurascens suppressed the proliferation of HT-29 colon cancer cells and triggered the induction of apoptosis through mitochondrial-dependent pathway.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2015 ;15:15. Epub 2015 Feb 5. PMID: 25652758

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcuma Purpurascens

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation

Additional Keywords : Dose Response

[+]

Berberine activates apoptosis to suppress triple-negative breast cancer cells.Aug 17, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Aug 18 ;95:18-24. Epub 2017 Aug 18. PMID: 28826092

Article Published Date : Aug 17, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Betanin significantly inhibits lung tumorigenesis in A/J mice and induces apoptosis in lung cancer cells. Aug 31, 2013

Click here to read the entire abstract

Pubmed Data : Mol Carcinog. 2013 Sep ;52(9):686-91. Epub 2012 Mar 27. PMID: 22456940

Article Published Date : Aug 31, 2013

Study Type : Animal Study

Additional Links

Substances : Beet, Betaine

Diseases : Benzo[a]pyrene-induced Toxicity , Lung Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anticarcinogenic Agents, Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Caspase-9 Activation, Chemopreventive

Additional Keywords : Beet, Benzo(a)pyrene, Betaine, lung cancer, Vinyl Carbamate

Problem Substances : Benzo(a)pyrene, Vinyl Carbamate

[+]

Oral administration of apple procyanidins inhibits the proliferation of tumor cells by inducing apoptosis through the intrinsic mitochondrial pathway.Feb 29, 2008

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 2008 Mar ;29(3):585-93. Epub 2007 Sep 7. PMID: 17827407

Article Published Date : Feb 29, 2008

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Apple

Diseases : Melanoma

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation

Additional Keywords : Proanthocyanidins

[+]

The herbal preparation Shemamruthaa had antiproliferative and apoptotic effects on chemically induced breast cancer.Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : J Evid Based Complementary Altern Med. 2015 Oct ;20(4):259-68. Epub 2015 Apr 17. PMID: 25888591

Article Published Date : Sep 30, 2015

Study Type : Animal Study

Additional Links

Substances : Shemamruthaa

Diseases : Breast Cancer, Breast Cancer: Chemically-Induced

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Tumor Suppressor Protein p53 Upregulation

[+]

These results suggest that the combination viscumTT may have a potential therapeutic value for the treatment AML.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : PLoS One. 2015;10(8):e0133892. Epub 2015 Aug 5. PMID: 26244918

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Mistletoe

Diseases : Acute Myeloid Leukemia

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-8 activation, Caspase-9 Activation

Additional Keywords : Dose Response, Plant Extracts

[+]

Tocotrienols are potent antitumor agents capable of inducing apoptosis and inhibiting angiogenesis under both hypoxic and normoxic conditions.Jul 31, 2015

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2015 Aug ;26(8):832-40. Epub 2015 Apr 14. PMID: 25979648

Article Published Date : Jul 31, 2015

Study Type : Animal Study

Additional Links

Substances : Tocotrienol: Delta, Vitamin E

Diseases : Colorectal Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, P21 Activation

Additional Keywords : Dose Response

[+]

Ursolic acid exhibits significant anti-tumor effects by suppressing cell proliferation, promoting apoptosis in gallbladder cancer cells. Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2014 ;14(1):96. Epub 2014 Oct 29. PMID: 25383044

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ursolic Acid

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest

Additional Keywords : Dose Response

[+]

Abrogation of HDGF by EGCG enhances cisplatin-induced apoptosis and sensitizes A549 cells to chemotherapy.Jul 13, 2015

Click here to read the entire abstract

Pubmed Data : Proteomics Clin Appl. 2015 Jul 14. Epub 2015 Jul 14. PMID: 26175166

Article Published Date : Jul 13, 2015

Study Type : In Vitro Study

Additional Links

Diseases : Lung Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Chemosensitizer

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Avocado defensin could induce intrinsic apoptosis in breast cancer cells.Jul 31, 2016

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2016 Aug ;82:620-7. Epub 2016 Jun 13. PMID: 27470405

Article Published Date : Jul 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Avocado

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Caspase-7 Activation , Caspase-9 Activation

Additional Keywords : Apoptotic, Avocado, Breast Cancer, Caspase-7 Activation, Caspase-9 Activation

[+]

Bisdemethoxycurcumin induced cell apoptosis through multiple signal pathways such as extrinsic, intrinsic and ES tress pathway.Sep 14, 2015

Click here to read the entire abstract

Pubmed Data : Environ Toxicol. 2015 Sep 15. Epub 2015 Sep 15. PMID: 26370218

Article Published Date : Sep 14, 2015

Study Type : In Vitro Study

Additional Links

Substances : Bisdemethoxycurcumin

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Cell cycle arrest

[+]

Bisdemethoxycurcumin suppresses human osteosarcoma U‑2 OS cell migration and invasion.Nov 30, 2022

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2022 Dec ;48(6). Epub 2022 Oct 12. PMID: 36222295

Article Published Date : Nov 30, 2022

Study Type : In Vitro Study

Additional Links

Substances : Bisdemethoxycurcumin

Diseases : Osteosarcoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Caspase-9 Activation, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor

[+]

Blueberry anthocyanins inhibited proliferation and induced apoptosis in oral cancer cells in a dose dependent manner. Jun 19, 2014

Click here to read the entire abstract

Pubmed Data : Yi Chuan. 2014 Jun 20 ;36(6):566-73. PMID: 24929515

Article Published Date : Jun 19, 2014

Study Type : In Vitro Study

Additional Links

Substances : Anthocyanins, Blueberry

Diseases : Oral Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-9 Activation, Cell cycle arrest, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Epigenetic Modification, Methylation Downregulation

[+]

Carnosic acid induced apoptosis in HCT116 cells via generation of ROS, induction of p53, activation of caspases, and inhibition of STAT3 signaling pathway.Jul 07, 2015

Click here to read the entire abstract

Pubmed Data : Mol Carcinog. 2015 Jul 8. Epub 2015 Jul 8. PMID: 26152521

Article Published Date : Jul 07, 2015

Study Type : In Vitro Study

Additional Links

Substances : Carnosic Acid, Rosemary

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation, STAT3 Inhibitor, Tumor Suppressor Protein p53 Upregulation

[+]

Curcumin could induce apoptosis in pancreatic cancer cells.Sep 30, 2015

Click here to read the entire abstract

Pubmed Data : Mol Med Rep. 2015 Oct ;12(4):5415-22. Epub 2015 Jul 8. PMID: 26166196

Article Published Date : Sep 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Pancreatic Cancer

Pharmacological Actions : Apoptotic, Bax/Bcl2 Ratio: Decrease, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest

[+]

Demethoxycurcumin may induce apoptosis of skin cancer cells through a caspase dependent pathway.Jun 30, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2017 Jul ;16(1):539-546. Epub 2017 May 31. PMID: 28586041

Article Published Date : Jun 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Demethoxycurcumin

Diseases : Skin Cancer: Squamous Cell

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

DHA and EPA are found to exhibit growth-inhibitory effect on the human neuroblastoma LA-N-1 cells.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2015 ;7(8):6956-73. Epub 2015 Aug 18. PMID: 26295255

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), EPA (Eicosapentaenoic Acid)

Diseases : Neuroblastoma

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest

[+]

Hyperoside and rutin from lotus roots may be the promising candidates for treatment of colon cancer.Mar 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2016 Apr ;11(4):2463-2470. Epub 2016 Feb 18. PMID: 27073499

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lotus , Rutin

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

[+]

In the current study we demonstrated that cannabidiol can induce apoptosis in murine as well as human leukemia cells.Aug 31, 2006

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Pharmacol. 2006 Sep ;70(3):897-908. Epub 2006 Jun 5. PMID: 16754784

Article Published Date : Aug 31, 2006

Study Type : In Vitro Study

Additional Links

Substances : Cannabidiol

Diseases : Leukemia

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, NADPH Oxidase Inhibitors

Additional Keywords : Cannabinoid Receptors

[+]

Isoflavones extracted from chickpea sprouts induce mitochondria-dependent apoptosis in human breast cancer cells.Jan 31, 2015

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2015 Feb ;29(2):210-9. Epub 2014 Oct 7. PMID: 25287332

Article Published Date : Jan 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Chickpea, Isoflavones

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-7 Activation , Caspase-9 Activation, Chemopreventive, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Dose Response, Plant Extracts

[+]

Lethariella zahlbruckneri extract inhibited HT-29 cell proliferation by inducing apoptosis.Aug 31, 2009

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2009 Sep ;47(9):2157-62. Epub 2009 Jun 6. PMID: 19501127

Article Published Date : Aug 31, 2009

Study Type : In Vitro Study

Additional Links

Substances : Lichens

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-8 activation, Caspase-9 Activation

Additional Keywords : Dose Response, Plant Extracts

[+]

Lichen metabolites showed various cytotoxic effects in a concentration-dependent manner against cancer cells. Feb 28, 2013

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2013 Mar ;27(3):431-7. Epub 2012 May 25. PMID: 22628260

Article Published Date : Feb 28, 2013

Study Type : In Vitro Study

Additional Links

Substances : Lichens

Diseases : Breast Cancer, Cervical Cancer, Colon Cancer, Oxidative Stress

Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

Additional Keywords : Dose Response, Metabolites

[+]

Lion's mane induces programmed cell death in monocytic leukemia cells. Jun 01, 2011

Click here to read the entire abstract

Pubmed Data : Food Funct. 2011 Jun ;2(6):348-56. Epub 2011 Jun 8. PMID: 21779573

Article Published Date : Jun 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Infant Acute Monocytic Leukemia, Leukemia: Monocytic

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2017 Feb ;100:149-160. Epub 2016 Dec 23. PMID: 28025124

Article Published Date : Jan 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Hawthorn, Ursolic Acid

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Cyclin D1 Down-Regulation

Additional Keywords : Antiproliferative, Breast Cancer: Triple Negative, Dose Response, Hawthorn, Ursolic Acid

[+]

Melatonin sensitizes the cisplatin-mediated growth suppression of liver cancer cells.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Am J Cancer Res. 2017 ;7(1):13-27. Epub 2017 Jan 1. PMID: 28123844

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Chemosensitizer, NF-kappaB Inhibitor

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

MLAuNP possesses antiproliferative properties and induced apoptosis in A549 cells by activating alternate splicing of caspase-9.Feb 28, 2016

Click here to read the entire abstract

Pubmed Data : J Cell Biochem. 2016 Feb 29. Epub 2016 Feb 29. PMID: 26923760

Article Published Date : Feb 28, 2016

Study Type : In Vitro Study

Additional Links

Substances : Gold (nanoparticles), Moringa oleifera

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-9 Activation, Tumor Suppressor Protein p53 Upregulation

[+]

Morus alba leaf lectin has possible antimetastatic effects by inducing anoikis in MCF-7 cells.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2017 ;8:34. Epub 2017 Feb 7. PMID: 28223935

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : White Mulberry

Diseases : Breast Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Caspase-9 Activation, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Plant Extracts

[+]

Natural compounds present in oyster mushroom could modulate apoptosis and cell cycle pathways that are frequently blocked in human cancers.Apr 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arch Iran Med. 2015 May ;18(5):284-95. PMID: 25959910

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Mushrooms: All , Oyster Mushroom

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, P21 Activation

[+]

Oridonin effectively inhibited cell proliferation and induced apoptosis in HCT-116 and LoVo cells in a concentration-dependent manner.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2015 May ;72:125-34. Epub 2015 Apr 27. PMID: 26054686

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Oridonin

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, MicroRNA modulator

Additional Keywords : Dose Response

[+]

Resveratraol induces cell death in human ovarian cancer cells. Nov 01, 2010

Click here to read the entire abstract

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2010 Nov;30(11):2440-2. PMID: 21097399

Article Published Date : Nov 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Ovarian Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Resveratrol could suppress hyperplasia of synovial cells, a critical factor of rheumatoid arthritis.Aug 10, 2010

Click here to read the entire abstract

Pubmed Data : Rheumatol Int. 2010 Aug 10. Epub 2010 Aug 10. PMID: 20697895

Article Published Date : Aug 10, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Arthritis: Rheumatoid

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Resveratrol induces programmed cell death in ovarian cancer cells. Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : J Med Food. 2011 Jan-Feb;14(1-2):46-52. Epub 2010 Dec 27. PMID: 21186985

Article Published Date : Jan 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Ovarian Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

Shikonin exhibited its anti-tumor activity against HGC-27 cells through inhibiting cell growth and promoting apoptosis by targeting mitochondrial-related signaling pathway.Mar 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacogn Mag. 2015 Apr-Jun;11(42):250-6. PMID: 25829762

Article Published Date : Mar 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Lithospermum erythrorhizon, Shikonin

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

[+]

Tetrahydrocurcumin is more effective than curcumin in inducing the apoptosis of H22 cells.Aug 01, 2017

Click here to read the entire abstract

Pubmed Data : Food Funct. 2017 Aug 2. Epub 2017 Aug 2. PMID: 28766664

Article Published Date : Aug 01, 2017

Study Type : In Vitro Study

Additional Links

Substances : Tetrahydrocurcumin

Diseases : Liver Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

The green tea polyphenol EGCG enhances the anti-cancer activity of bortezomib in multiple myeloma cells. Dec 01, 2009

Click here to read the entire abstract

Pubmed Data : Acta Biochim Biophys Sin (Shanghai). 2009 Dec;41(12):1018-26. PMID: 20011976

Article Published Date : Dec 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Catechin , Tea

Diseases : Multiple Myeloma

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Chemosensitizer

Additional Keywords : Drug: Bortezomib, Drug Synergy

[+]

These findings suggest that mango kernel extract has potential to be developed into a therapeutic mixture for treatment of breast cancers.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2015 ;15:45. Epub 2015 Mar 9. PMID: 25881293

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Mango Seed

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Redox Modulator

Additional Keywords : Dose Response

[+]

These results reveal that Taiwanofungus salmoneus could be a potential adjuvant chemotherapeutic agent.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Int J Med Mushrooms. 2015 ;17(6):567-77. PMID: 26349514

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Medicinal Mushrooms, Mushrooms: All

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation, Cell cycle arrest, Chemotherapeutic

Additional Keywords : Drug: Cisplatin, Plant Extracts

Problem Substances : Cisplatin

[+]

These results suggested that cucurbitacin E maybe used as a therapeutic agent in the treatment of human prostate cancer.May 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncol Lett. 2017 Jun ;13(6):4905-4910. Epub 2017 Apr 24. PMID: 28599494

Article Published Date : May 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin E

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-9 Activation, Tumor Suppressor Protein p53 Upregulation

[+]

Tualang honey has significant anticancer activity against human breast and cervical cancer cell lines.Mar 31, 2011

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2011 Apr ;49(4):871-8. Epub 2010 Dec 16. PMID: 21167897

Article Published Date : Mar 31, 2011

Study Type : In Vitro Study

Additional Links

Substances : Tualang Honey

Diseases : Breast Cancer, Breast Cancer: Triple Negative , Cervical Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, Caspase-7 Activation , Caspase-9 Activation

[+]

Tulsi extracts can effectively induce apoptosis in prostate cancer cells.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Jul ;18(7):776-85. Epub 2015 Feb 18. PMID: 25692494

Article Published Date : Jun 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Holy Basil

Diseases : Prostate Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Caspase-9 Activation

Additional Keywords : Plant Extracts

[+]

White tea extract showed high anti-proliferative activity against HT-29 cells, without being toxic to normal fibroblasts.Feb 14, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Food Chem. 2015 Feb 15 ;169:401-10. Epub 2014 Jul 8. PMID: 25236244

Article Published Date : Feb 14, 2015

Study Type : In Vitro Study

Additional Links

Substances : White Tea

Diseases : Colon Cancer, Colon Cancer: Prevention, DNA damage

Pharmacological Actions : Antioxidant, Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

Additional Keywords : DNA Protective, Plant Extracts

[+]

Xanthohumol induces cell death in human malignant glioblastoma cells. Dec 27, 2011

Click here to read the entire abstract

Pubmed Data : J Nat Prod. 2011 Dec 27 ;74(12):2505-13. Epub 2011 Nov 23. PMID: 22111577

Article Published Date : Dec 27, 2011

Study Type : In Vitro Study

Additional Links

Substances : Xanthohumol

Diseases : Glioblastoma

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Caspase-3 Activation, Caspase-9 Activation

[+]

α-tomatine in pure form and in tomatine rich green tomatoes might prevent colon cancer.Jan 22, 2015

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2015 Jan 23. Epub 2015 Jan 23. PMID: 25614934

Article Published Date : Jan 22, 2015

Study Type : In Vitro Study

Additional Links

Substances : Tomato

Diseases : Colon Cancer, Colon Cancer: Prevention

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Caspase-9 Activation

Caspase-9 Activation jQuery(function ($) { $(".node-field-image").click(function () { $(".node-field-image").toggleClass("open"); }); $(".node.topic>.colfull").click(function () { $(".node.topic>.colfull").toggleClass("open"); }); })

Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 47 Abstracts with Caspase-9 Activation Research

Limited to Members Only

Currently Available Sorting Options

A Nigella sativa extract showed a 88.3% inhibition of proliferation of SiHa human cervical cancer cells and increased the expression of caspase-3, -8 and -9 several-foldJan 31, 2013

Chrysin induces apoptosis of human uveal melanoma cells.Nov 30, 2016

Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.Mar 31, 2014

Sanguinarine induces apoptosis of human oral squamous cell carcinoma KB cells.Jul 31, 2016

An extract of Curcuma purpurascens suppressed the proliferation of HT-29 colon cancer cells and triggered the induction of apoptosis through mitochondrial-dependent pathway.Dec 31, 2014

Berberine activates apoptosis to suppress triple-negative breast cancer cells.Aug 17, 2017

Betanin significantly inhibits lung tumorigenesis in A/J mice and induces apoptosis in lung cancer cells. Aug 31, 2013

Oral administration of apple procyanidins inhibits the proliferation of tumor cells by inducing apoptosis through the intrinsic mitochondrial pathway.Feb 29, 2008

The herbal preparation Shemamruthaa had antiproliferative and apoptotic effects on chemically induced breast cancer.Sep 30, 2015

These results suggest that the combination viscumTT may have a potential therapeutic value for the treatment AML.Dec 31, 2014

Tocotrienols are potent antitumor agents capable of inducing apoptosis and inhibiting angiogenesis under both hypoxic and normoxic conditions.Jul 31, 2015

Ursolic acid exhibits significant anti-tumor effects by suppressing cell proliferation, promoting apoptosis in gallbladder cancer cells. Dec 31, 2013

Abrogation of HDGF by EGCG enhances cisplatin-induced apoptosis and sensitizes A549 cells to chemotherapy.Jul 13, 2015

Avocado defensin could induce intrinsic apoptosis in breast cancer cells.Jul 31, 2016

Bisdemethoxycurcumin induced cell apoptosis through multiple signal pathways such as extrinsic, intrinsic and ES tress pathway.Sep 14, 2015

Bisdemethoxycurcumin suppresses human osteosarcoma U‑2 OS cell migration and invasion.Nov 30, 2022

Blueberry anthocyanins inhibited proliferation and induced apoptosis in oral cancer cells in a dose dependent manner. Jun 19, 2014

Carnosic acid induced apoptosis in HCT116 cells via generation of ROS, induction of p53, activation of caspases, and inhibition of STAT3 signaling pathway.Jul 07, 2015

Curcumin could induce apoptosis in pancreatic cancer cells.Sep 30, 2015

Demethoxycurcumin may induce apoptosis of skin cancer cells through a caspase dependent pathway.Jun 30, 2017

DHA and EPA are found to exhibit growth-inhibitory effect on the human neuroblastoma LA-N-1 cells.Dec 31, 2014

Hyperoside and rutin from lotus roots may be the promising candidates for treatment of colon cancer.Mar 31, 2016

In the current study we demonstrated that cannabidiol can induce apoptosis in murine as well as human leukemia cells.Aug 31, 2006

Isoflavones extracted from chickpea sprouts induce mitochondria-dependent apoptosis in human breast cancer cells.Jan 31, 2015

Lethariella zahlbruckneri extract inhibited HT-29 cell proliferation by inducing apoptosis.Aug 31, 2009

Lichen metabolites showed various cytotoxic effects in a concentration-dependent manner against cancer cells. Feb 28, 2013

Lion's mane induces programmed cell death in monocytic leukemia cells. Jun 01, 2011

Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

Melatonin sensitizes the cisplatin-mediated growth suppression of liver cancer cells.Dec 31, 2016

MLAuNP possesses antiproliferative properties and induced apoptosis in A549 cells by activating alternate splicing of caspase-9.Feb 28, 2016

Morus alba leaf lectin has possible antimetastatic effects by inducing anoikis in MCF-7 cells.Dec 31, 2016

Natural compounds present in oyster mushroom could modulate apoptosis and cell cycle pathways that are frequently blocked in human cancers.Apr 30, 2015

Oridonin effectively inhibited cell proliferation and induced apoptosis in HCT-116 and LoVo cells in a concentration-dependent manner.Apr 30, 2015

Resveratraol induces cell death in human ovarian cancer cells. Nov 01, 2010

Resveratrol could suppress hyperplasia of synovial cells, a critical factor of rheumatoid arthritis.Aug 10, 2010

Resveratrol induces programmed cell death in ovarian cancer cells. Jan 01, 2011

Shikonin exhibited its anti-tumor activity against HGC-27 cells through inhibiting cell growth and promoting apoptosis by targeting mitochondrial-related signaling pathway.Mar 31, 2015

Tetrahydrocurcumin is more effective than curcumin in inducing the apoptosis of H22 cells.Aug 01, 2017

The green tea polyphenol EGCG enhances the anti-cancer activity of bortezomib in multiple myeloma cells. Dec 01, 2009

These findings suggest that mango kernel extract has potential to be developed into a therapeutic mixture for treatment of breast cancers.Dec 31, 2014

These results reveal that Taiwanofungus salmoneus could be a potential adjuvant chemotherapeutic agent.Dec 31, 2014

These results suggested that cucurbitacin E maybe used as a therapeutic agent in the treatment of human prostate cancer.May 31, 2017

Tualang honey has significant anticancer activity against human breast and cervical cancer cell lines.Mar 31, 2011

Tulsi extracts can effectively induce apoptosis in prostate cancer cells.Jun 30, 2015

White tea extract showed high anti-proliferative activity against HT-29 cells, without being toxic to normal fibroblasts.Feb 14, 2015

Xanthohumol induces cell death in human malignant glioblastoma cells. Dec 27, 2011

α-tomatine in pure form and in tomatine rich green tomatoes might prevent colon cancer.Jan 22, 2015

Print Options

Caspase-9 Activation

View the Evidence:
47 Abstracts with Caspase-9 Activation Research