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Cell cycle arrest
Views 2036
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468 Substances Researched for Cell cycle arrest
Name
AC
CK
Focus
Curcumin
118
132
Flavonoids
43
58
Resveratrol
48
56
Sulforaphane
31
39
Polyphenols
24
34
Ginsenosides
29
33
Lycopene
8
27
Berberine
23
26
Cucurbitacin B
21
26
Quercetin
24
25
Genistein
19
23
Licorice
19
22
Pterostilbene
16
21
Apigenin
8
20
Thymoquinone
11
18
Fucoidan
16
17
Piperine
8
17
Indole-3-Carbinol
12
16
Silibinin
6
15
Vitamin C
14
15
Daidzein
10
14
Milk Thistle
5
14
Water: Deuterium Depleted
4
14
Xanthohumol
12
14
Catechin
11
13
EGCG (Epigallocatechin gallate)
12
13
Frankincense
5
13
Reishi Mushroom
9
13
Caffeic Acid
3
12
Kaempferol
12
12
Luteolin
11
12
Myricetin
12
12
Tanshinone IIA
11
12
Garlic
11
11
Magnolol
6
11
Oridonin
10
11
Vitamin E
10
11
Antrodia camphorata
4
10
Caffeine
1
10
Honokiol
9
10
Huaier (Trametes robiniophila murr)
8
10
Motherwort
1
10
Phellinus Linteus
8
10
Stilbenes
9
10
Anthocyanins
7
9
Artemisinin
8
9
Dogwood
4
9
Ellagic Acid
4
9
Formononetin
7
9
Gingerol
8
9
Isothiocyanates
9
9
Mulberry
3
9
Tocotrienol: Gamma
5
9
Ursolic Acid
8
9
Bisdemethoxycurcumin
4
8
Carnosic Acid
7
8
Cruciferous Vegetables
8
8
Fisetin
8
8
Grape Seed Extract
5
8
Graviola
4
8
Isoflavones
6
8
Isoliquiritigenin
7
8
Maitake Mushroom
6
8
Melatonin
8
8
Nobiletin
7
8
Pomegranate
4
8
Rhubarb
4
8
Sesamin
4
8
Shallot
6
8
Tetrahydrocurcumin
3
8
Vitamin D
8
8
Ashwagandha
6
7
Astaxanthin
6
7
Baicalein
5
7
Benzyl isothiocyanate
5
7
Chokeberry
3
7
Curcumol
5
7
Deguelin
7
7
Diosgenin
6
7
Ginger
5
7
Green Tea
5
7
Mushrooms: All
3
7
Paeoniflorin
6
7
Phloretin
7
7
Shikonin
5
7
Tocotrienol: Delta
6
7
Bee Propolis
5
6
Beta-Elemene
6
6
Caffeic acid phenethyl ester
5
6
Cannabidiol
5
6
Cannabinoids
5
6
Carrot
2
6
Celastrol
5
6
Chaga Mushroom (Inonotus obliquus)
5
6
Citral
2
6
Cucurbitacin E
6
6
Emodin
6
6
Fucoxanthin
6
6
Lignans
5
6
Manuka Honey
2
6
Oleanolic acid
5
6
Piceatannol
6
6
Prickly Pear Cactus
5
6
Proanthocyanidins
5
6
Prunella vulgaris
4
6
Wogonin
6
6
6-Shogaol
4
5
Amygdalin
5
5
Apples
4
5
Arctigenin
1
5
Betulinic acid
5
5
Chrysin
4
5
Cinnamon
5
5
Cordyceps Militaris
5
5
Cucurbitacin D
4
5
Curcumin: Degradiation byproducts
1
5
Demethoxycurcumin
5
5
Evodiamine
4
5
Fiber
4
5
Gac
3
5
Garlic: Aged
1
5
Gynostemma
5
5
Homeopathic Medicine: All
4
5
Lactoferrin
5
5
Lemongrass
1
5
Lichens
4
5
Mangosteen
4
5
Medicinal Mushrooms
3
5
Naringenin
5
5
Piperlongumine
4
5
Psychedelics:All
4
5
Soy
4
5
Sprouts
4
5
Toona sinensis
3
5
Vitamin E: Gamma-tocotrienol
5
5
Vitamin K
5
5
Alpinia galanga
3
4
Artesunate
4
4
Bai Zhu
3
4
Beans: All
3
4
Berbamine
3
4
Bitter Melon
4
4
Blueberry
3
4
Broccoli
4
4
DHA (Docosahexaenoic Acid)
4
4
Delta-tetrahydrocannabinol (THC)
3
4
Diosmetin
4
4
Gallic Acid
3
4
Ginkgo biloba
3
4
Hesperidin
3
4
Inositol Hexaphosphate
3
4
Mangiferin
3
4
Mistletoe
3
4
Moringa oleifera
4
4
Nordihydroguaiaretic acid (NDGA)
2
4
Oleuropein
4
4
Parthenolide
4
4
Puerarin
4
4
Rosemary
4
4
Sandalwood
4
4
Shiitake Mushroom
3
4
Solanum nigrum (black nightshade)
3
4
Tangeretin
4
4
Turmeric
4
4
Wheat Grass
3
4
Whey
3
4
Zerumbone
4
4
Aloe Vera
2
3
Angelica
2
3
Apple Polyphenols
3
3
Asiatic Acid
3
3
Babchi
2
3
Bacopa
3
3
Bee Venom
3
3
Beta Sitosterol
3
3
Bufalin
3
3
Cannabinoids: Synthetic
2
3
Capsaicin
3
3
Carnosol
2
3
Carotenoids
3
3
Carvacrol
3
3
Chlorogenic Acid
3
3
Chrysanthemum Indicum
3
3
Collagen
2
3
Cordyceps sinensis
2
3
Crocin
3
3
Curry Leaves
2
3
Daisy
2
3
Dimethyl trisulfide (DMTS)
2
3
Echinacea
2
3
Ferulic acid
3
3
Ginseng
3
3
Gold (nanoparticles)
3
3
Litchi
2
3
Lotus
3
3
Magnolia
3
3
Nettle
3
3
Nexrutine (Phellodendrom)
2
3
Olive leaf extract
2
3
Peony
2
3
Perilla
3
3
Pine Needle
3
3
Rose
3
3
Rosemaric Acid
3
3
Rosmarinic acid
2
3
Spirulina
2
3
Syrian rue
2
3
Urolithin A
2
3
Walnut
3
3
acetyl-11-keto-beta-boswellic acid
3
3
beta-Carotene
3
3
Adlay
2
2
Allicin
2
2
Anthurium schlechtendalii
1
2
Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine)
1
2
Antineoplastons
2
2
Banaba
2
2
Barberry
2
2
Barley
1
2
Biochanin A
2
2
Bitter Orange
2
2
Black Cohosh
2
2
Black Pepper
1
2
Black Tea
2
2
Boswellia
1
2
Broccoli Sprouts
1
2
Butyrate
2
2
Catechols
2
2
Chinese Skullcap
2
2
Chlorella (Algae)
1
2
Cinnamaldehyde
2
2
Citrus Peel
2
2
Citrus naringin
2
2
Cranberry
2
2
Curcuminoids
2
2
Cyanidin 3-glucoside
2
2
Dandelion
2
2
Diallyl sulfide
2
2
Dill
2
2
Diosmin
1
2
Eucalyptus
2
2
Fermented Foods and Beverages
2
2
Fig
2
2
Flaxseed
1
2
Fruit Peel
1
2
Genipin
1
2
Ginseng (American)
2
2
Ginseng (Siberian)
2
2
Grape
2
2
Honeysuckle
2
2
Hydroxytyrosol
2
2
Isoquercitrin
1
2
Japanese mugwort
2
2
Lactococcus lactis
2
2
Ligustrazine
2
2
Lime
2
2
Lion's Mane (Hericium Erinaceus)
2
2
Lupeol
2
2
MSM (Methylsulfonylmethane)
2
2
Modified Arabinoxylan Rice Bran (MGN-3)
1
2
Modified Citrus Pectin
1
2
Neem
2
2
Noni leaf extract
1
2
Olive
2
2
Organosulfur Compounds
2
2
Oyster Mushroom
2
2
Paeonol
2
2
Panax Ginseng
1
2
Panax Notoginseng
2
2
Passion Flower
1
2
Peanut
1
2
Phenethyl isothiocyanate
2
2
Pine Bark Extract
2
2
Pomegranate Peel
2
2
Probiotics
2
2
Propolis: Brazillian
2
2
Rhodiola (Tibetan Ginseng)
2
2
Rose Hips
2
2
Ruta Graveolens
2
2
Safflower
2
2
Saffron
2
2
Saturated fatty acids
1
2
Sea buckthorn
2
2
Selenium
2
2
Sesame Seeds
2
2
Soy Protein
1
2
Stearic Acid (stearate)
1
2
Strawberry
1
2
Sweet Potato: Purple
1
2
Tea
2
2
Theaflavins
2
2
Thymol
2
2
Tocotrienols
1
2
Tomato
1
2
Trichosanthes Kirilowii
1
2
Vitamin A
2
2
Vitamin E: alpha tocopherol
2
2
Vitamin E: delta-tocopherol
2
2
Wasabi
2
2
Wheat Germ
2
2
2-Methoxyestradiol
1
1
Agaricus Blazei
1
1
Aleurone
1
1
Algae
1
1
Andrographis
1
1
Apple Pectin
1
1
Asparagus
1
1
Astragaloside
1
1
Astragalus
1
1
Banana
1
1
Bergamot orange
1
1
Berries: All
1
1
Beta-Caryophyllene
1
1
Beta-glucan
1
1
Betaine
1
1
Betel
1
1
Bitter Apple
1
1
Black Bean
1
1
Bromelain
1
1
Brown Rice
1
1
Brussel sprouts
1
1
Burdock
1
1
Cafestol
1
1
Camel Milk
1
1
Cannabis
1
1
Capparis spinosa (caper)
1
1
Cardamonin
1
1
Carnosine
1
1
Cashew
1
1
Celery
1
1
Celery seed
1
1
Chives
1
1
Citrus aurantium
1
1
Cleavers
1
1
Cocoa
1
1
Copper
1
1
Coptidis rhizoma
1
1
Coriolus versicolor
1
1
Corn Silk
1
1
Corn: Purple
1
1
Cryptomeria japonica
1
1
Cryptoxanthin
1
1
Curry Tree
1
1
D-Limonene
1
1
Decursin
1
1
Dragon Fruit
1
1
EPA (Eicosapentaenoic Acid)
1
1
Egg
1
1
Epimedium
1
1
Eriodictyol
1
1
Eugenol
1
1
False Black Pepper
1
1
Fennel
1
1
Flavan-3-ols
1
1
Flaxseed Oil
1
1
Folate
1
1
Galbanic Acid
1
1
Garcinia dulcis
1
1
Geranium
1
1
Ginseng (Korean)
1
1
Glycitein
1
1
Glycyrrhizin
1
1
Goji
1
1
Gold
1
1
Goldenthread
1
1
Grapefruit
1
1
Guava
1
1
Guduchi
1
1
HDTIC-1
1
1
HDTIC-2
1
1
Hawthorn
1
1
Helenalin
1
1
Hemp Seed
1
1
Hibiscus
1
1
Hibiscus sabdariffa
1
1
Honey
1
1
Hops
1
1
Hydrangea
1
1
Hydrogen Peroxide
1
1
Indian Gooseberry
1
1
Iodine
1
1
Jujube
1
1
Juniper
1
1
Kava Kava
1
1
Kimchi
1
1
Lactobacillus gasseri
1
1
Lactobacillus paracasei
1
1
Lactobacillus plantarum
1
1
Lactobacillus rhamnosus GG
1
1
Leek
1
1
Lemon Balm
1
1
Lettuce
1
1
Lithospermum erythrorhizon
1
1
Lobelia
1
1
Lutein
1
1
Lychee
1
1
Molasses
1
1
Mustard Oil
1
1
Nigella sativa (aka Black Seed)
1
1
Noni
1
1
Oats
1
1
Olive Oil
1
1
Onion
1
1
Orange
1
1
Oregano
1
1
Orthosiphon
1
1
Oyster Mushroom: Golden
1
1
P-Coumaric Acid
1
1
Palash
1
1
Palm Oil
1
1
Papaya
1
1
Parsley
1
1
Pau D'Arco
1
1
Pea
1
1
Peach
1
1
Pelargonium sidoides
1
1
Phyllanthus emblica
1
1
Pinus Massoniana Bark
1
1
Pistachio nut
1
1
Pleurotus nebrodensis
1
1
Propolis: Bee
1
1
Punicalagin
1
1
Raspberry
1
1
Red Marine Algae
1
1
Red Wine Extract
1
1
Rice Bran
1
1
Rooibos
1
1
Rose: Essential Oil
1
1
Roselle
1
1
Rutin
1
1
S-Adenosylmethionine (SAMe)
1
1
Safranal
1
1
Sage
1
1
Salvia miltiorrhiza
1
1
Schisandra
1
1
Scutellaria barbata
1
1
Seaweed
1
1
Seaweed: Brown
1
1
Sembung Leaf
1
1
Sesamol
1
1
Silver (nanoparticles)
1
1
Soursop
1
1
Spikenard
1
1
Stevia
1
1
Sumac
1
1
Tannic Acid
1
1
Thistle
1
1
Toad
1
1
Traditional Chinese Medicine: Mylabris
1
1
Tribulus
1
1
Turkey Tail Mushroom
1
1
Turmerones
1
1
Tyrosol
1
1
Vanillin
1
1
Verbascoside
1
1
Vitamin C: Intravenous
1
1
Vitamin E: Gamma-Tocopherol
1
1
Vitamin K2
1
1
Vitex negundo
1
1
Vitexins
1
1
Wedelia chinensis
1
1
Wheat Bran
1
1
Wheat: Fermented
1
1
White Mulberry
1
1
Xanthones
1
1
Zeaxanthin
1
1
Zyflamend
1
1
phytoestrogens
1
1
Research Articles
1348
Cumulative Knowledge Score
2181
Overall Research Rating
EXCELLENT
View the Evidence:
1645 Abstracts with Cell cycle arrest Research
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[+]
Lycopene inhibits liver cancer cell growth.
Jan 01, 2005
Click here to read the entire abstract
Pubmed Data
: Biofactors. 2005 ;23(3):129-39. PMID:
16410635
Article Published Date
: Jan 01, 2005
Study Type
: Meta Analysis
Additional Links
Substances
:
Lycopene
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
,
Cell cycle arrest
[+]
Chinese motherwort has cytotoxicity against human breast cancer cells that is non-apoptic and estrogen receptor independent.
Mar 18, 2009
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2009 Mar 18;122(2):234-9. PMID:
19330917
Article Published Date
: Mar 18, 2009
Study Type
: Human Study
Additional Links
Substances
:
Motherwort
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
Genistein induces long-term expression of progesterone receptor regardless of estrogen receptor status and improves the prognosis of endometrial cancer patients.
Jun 17, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2022 Jun 18 ;12(1):10303. Epub 2022 Jun 18. PMID:
35717540
Article Published Date
: Jun 17, 2022
Study Type
: Human Study
Additional Links
Substances
:
Genistein
,
Progesterone
Diseases
:
Endometrial Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption.
Feb 16, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Cancer Res. 2015 Feb 17. Epub 2015 Feb 17. PMID:
25691730
Article Published Date
: Feb 16, 2015
Study Type
: Human Study
Additional Links
Substances
:
Caffeic Acid
,
Caffeine
Diseases
:
Breast Cancer
,
Breast Cancer: Estrogen
Pharmacological Actions
:
Anti-Tumor
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Estrogen Receptor Modulators
,
Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords
:
Dose Response
,
Risk Reduction
Problem Substances
:
Tamoxifen
[+]
The median survival time of patients in the deuterium depleted water consuming group was 2-4 times longer than it is generally observed in lung cancer patients.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutr Cancer. 2013 ;65(2):240-6. PMID:
23441611
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study, Human Study
Additional Links
Substances
:
Water: Deuterium Depleted
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Carcinoma: Small Cell Lung
,
Lung Cancer
,
Lung Cancer: Metastatic
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
Additional Keywords
:
Gene Expression Regulation
,
Proto-oncogene
[+]
An ethanolic extract of T. camphoratus treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2015 ;2015:415269. Epub 2015 Oct 18. PMID:
26557666
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Antrodia camphorata
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemosensitizer
,
P21 Activation
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
,
Chemotherapeutic Synergy: Doxorubicin
,
Plant Extracts
[+]
Apigenin highly upregulated the expression of cytokine genes and induced apoptosis in human pancreatic cancer cells.
Nov 30, 2013
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2013 Dec ;57(12):2112-27. Epub 2013 Aug 14. PMID:
23943362
Article Published Date
: Nov 30, 2013
Study Type
: Human In Vitro
Additional Links
Substances
:
Apigenin
,
Flavonoids
Diseases
:
Inflammation
,
Pancreatic Cancer
Pharmacological Actions
:
Anti Inflammatory
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor
,
NF-kappaB Inhibitor
Additional Keywords
:
Epigenetic Modification In Cancer
[+]
Apigenin is a novel therapeutic candidate for melanoma.
Feb 13, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Feb 14. Epub 2017 Feb 14. PMID:
28260058
Article Published Date
: Feb 13, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Apigenin
Diseases
:
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
[+]
Arctigenin is able to inhibit cell proliferation and may induce apoptosis and cell cycle arrest at the G0/G1 phase in glioma cells.
Jan 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: Oncol Lett. 2017 Feb ;13(2):1007-1013. Epub 2016 Dec 8. PMID:
28356992
Article Published Date
: Jan 31, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Arctigenin
Diseases
:
Glioma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Bisdemethoxycurcumin induced changes in gene expression that may reveal cytotoxic information on the genetic level.
Jan 10, 2015
Click here to read the entire abstract
Pubmed Data
: In Vivo. 2015 11-12;29(6):711-728. PMID:
26546528
Article Published Date
: Jan 10, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Bisdemethoxycurcumin
Diseases
:
Lung Cancer
,
Non-Small-Cell Lung Carcinoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Gene Expression Regulation
[+]
chokeberry juice inhibited Caco-2 cell proliferation by causing G(2)/M cell cycle arrest.
Mar 31, 2007
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2007 Apr ;18(4):259-71. Epub 2006 Jul 24. PMID:
16860979
Article Published Date
: Mar 31, 2007
Study Type
: Human In Vitro
Additional Links
Substances
:
Chokeberry
,
Flavonoids
,
Polyphenols
Diseases
:
Colorectal Cancer
,
Colorectal Cancer: Prevention
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
[+]
Curcumin and citral in combination may be a useful therapeutic intervention for breast cancer.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Breast Cancer. 2015 Sep ;18(3):225-34. Epub 2015 Sep 24. PMID:
26472972
Article Published Date
: Aug 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Citral
,
Curcumin
,
Lemongrass
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
,
Natural Substance Synergy
,
Selective Cytotoxicity
[+]
Graviola extracts inhibited the proliferation of HL-60 cells in a concentration dependent manner and induced apoptosis.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2014 ;14(1):516. Epub 2014 Dec 24. PMID:
25539720
Article Published Date
: Dec 31, 2013
Study Type
: Human In Vitro
Additional Links
Substances
:
Graviola
Diseases
:
Acute Myeloid Leukemia
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
[+]
Human bladder cancer cells and immortalized normal bladder cells were studied using Frankincense oil; Frankincense oil appears to distinguish cancerous from normal bladder cells and suppress cancer cell viability.
Dec 31, 2008
Click here to read the entire abstract
Article Publish Status
: This is a free article.
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Pubmed Data
: BMC Complement Altern Med. 2009 ;9:6. Epub 2009 Mar 18. PMID:
19296830
Article Published Date
: Dec 31, 2008
Study Type
: Human In Vitro
Additional Links
Substances
:
Frankincense
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
,
Selective Cytotoxicity
[+]
M. nigra may be a novel candidate for the development of new natural product based therapeutic agents against prostate cancer.
Jan 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Saudi Pharm J. 2017 Feb ;25(2):241-248. Epub 2016 Jun 20. PMID:
28344475
Article Published Date
: Jan 31, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Mulberry
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Magnolol induced cell cycle arrest and promoted apoptosis in gallbladder carcinoma cells by regulating the p53 signaling pathway.
Sep 30, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Sci. 2015 Oct ;106(10):1341-50. PMID:
26250568
Article Published Date
: Sep 30, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Magnolol
Diseases
:
Gallbladder Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Cyclin D1 Down-Regulation
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
P. granatum extracts had cytotoxic and apoptotic effects on human U266 multiple myeloma cells via disruption of mitochondrial membrane potential and increasing cell cycle arrest.
Aug 28, 2015
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2015 Aug 29. Epub 2015 Aug 29. PMID:
26318303
Article Published Date
: Aug 28, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Pomegranate
Diseases
:
Multiple Myeloma
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Cytotoxic
Additional Keywords
:
Plant Extracts
[+]
Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2015 Jan ;24(1):50-8. Epub 2014 Nov 20. PMID:
25479727
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Piperine
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Piperine was found to exert selective cytotoxic effects against A549 cells in a dose-dependent manner.
Mar 31, 2014
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2014 Apr ;35(4):3305-10. Epub 2013 Nov 24. PMID:
24272201
Article Published Date
: Mar 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Piperine
Diseases
:
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Bax/Bcl2 ratio: Increase
,
Bcl-2 protein down-regulation
,
Caspase-3 Activation
,
Caspase-9 Activation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Selective Cytotoxicity
[+]
Pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.
Nov 07, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Nov 8 ;7(45):73200-73215. PMID:
27689322
Article Published Date
: Nov 07, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Pterostilbene
Diseases
:
Glioblastoma Multiforme
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Chemotherapeutic Synergy: Gefitinib
,
Natural Substance/Drug Synergy
[+]
Resveratrol markedly decreased the overexpression of miR-196b/miR-1290 and elevated IGFBP3 expression in the ALL cell lines.
Dec 14, 2016
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2016 Dec 15. Epub 2016 Dec 15. PMID:
28000876
Article Published Date
: Dec 14, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Resveratrol
Diseases
:
Acute lymphoblastic leukemia (ALL)
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
MicroRNA modulator
[+]
Tetrahydrocurcumin exhibited significant cell growth inhibition by inducing MCF-7 cells to undergo mitochondrial apoptosis and G2/M arrest.
Apr 30, 2014
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2014 May ;67:193-200. Epub 2014 Mar 1. PMID:
24593988
Article Published Date
: Apr 30, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Curcumin: Degradiation byproducts
,
Tetrahydrocurcumin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Caspase-3 Activation
,
Cell cycle arrest
,
P21 Activation
[+]
The present study results indicated that human bladder cancer T-24 cells are highly sensitive to growth inhibition by apigenin.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Cell Int. 2015 ;15:33. Epub 2015 Mar 29. PMID:
25859163
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Apigenin
Diseases
:
Bladder Cancer
,
Bladder Cancer: Prevention
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
[+]
The synergistic antiproliferative action of combined γ-tocotrienol and sesamin treatment in mouse and human mammary cancer cells was cytostatic, not cytotoxic.
Dec 31, 2012
Click here to read the entire abstract
Pubmed Data
: Fitoterapia. 2013 Jan ;84:347-59. Epub 2012 Dec 22. PMID:
23266736
Article Published Date
: Dec 31, 2012
Study Type
: Human In Vitro, In Vitro Study
Additional Links
Substances
:
Sesamin
,
Tocotrienol: Gamma
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Natural Substance Synergy
[+]
These results increase knowledge of the effect of gastrointestinal digestion on the biological effect of honey against colorectal cancer.
Jan 09, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2020 Jan 10 ;9(1). Epub 2020 Jan 10. PMID:
31936782
Article Published Date
: Jan 09, 2020
Study Type
: Human In Vitro
Additional Links
Substances
:
Manuka Honey
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
These results provide important new data for ellagic acid in anti-colorectal carcinoma research.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2017 Feb ;50(2):613-621. Epub 2017 Jan 5. PMID:
28101576
Article Published Date
: Jan 31, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Gene Expression Regulation
[+]
These results suggest that HEABG may be effective in the prevention and treatment of endometriosis in humans.
Jun 30, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Med. 2013 Jul ;32(1):67-78. Epub 2013 Apr 25. PMID:
23619991
Article Published Date
: Jun 30, 2013
Study Type
: Human In Vitro
Additional Links
Substances
:
Garlic: Aged
Diseases
:
Endometriosis
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Interleukin-6 Downregulation
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords
:
Plant Extracts
[+]
This study compares Boswellia sacra essential oil hydrodistilled at 100 °C vs 78 °C in inducing cancer cell death in cultured breast cancer cells; the oil prepared at 100 °C was more potent in inducing breast cancer cell-specific cytotoxicity.
Dec 31, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2011 ;11:129. Epub 2011 Dec 15. PMID:
22171782
Article Published Date
: Dec 31, 2010
Study Type
: Human In Vitro
Additional Links
Substances
:
Frankincense
Diseases
:
Breast Cancer
,
Cancer Metastasis
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Selective Cytotoxicity
[+]
This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.
Nov 01, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2018 Nov ;42(5):2447-2458. Epub 2018 Sep 6. PMID:
30226534
Article Published Date
: Nov 01, 2018
Study Type
: Human In Vitro
Additional Links
Substances
:
Sulforaphane
Diseases
:
Chemotherapy-Induced Toxicity: Cisplatin
,
Female
,
Ovarian Cancer
Pharmacological Actions
:
Anti-Tumor
,
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
HER-2 oncoprotein down-regulation
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Drug Synergy
,
Isothiocyanates
[+]
Thymoquinone promotes pancreatic cancer cell death and reduction of tumor size.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Adv Prev Med. 2016 ;2016:1407840. Epub 2016 Dec 26. PMID:
28105374
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Thymoquinone
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Histone deacetylase inhibitor
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Dose Response
[+]
verticillin A from Verticillium-infected wild mushrooms as a potent anti-cancer agent that effectively suppresses 5-FU-resistant human colon cancer cells.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Genom Data. 2015 Sep 1 ;5:189-191. PMID:
26309812
Article Published Date
: Aug 31, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Mushrooms: All
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
Additional Keywords
:
Chemothapeutic Synergy: 5-flourouracil
,
Epigenetic Modification In Cancer
,
Gene Expression Regulation
[+]
Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer.
Jan 09, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Altern Med. 2017 Jan 10 ;17(1):36. Epub 2017 Jan 10. PMID:
28073348
Article Published Date
: Jan 09, 2017
Study Type
: Animal Study, Human In Vitro
Additional Links
Substances
:
Carrot
Diseases
:
Skin Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
Additional Keywords
:
Plant Extracts
[+]
Amentoflavone induces caspase-dependent/-independent apoptosis and dysregulates cyclin-dependent kinase-mediated cell cycle in colorectal cancer.
Apr 30, 2023
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2023 May ;38(5):1078-1089. Epub 2023 Feb 2. PMID:
36727907
Article Published Date
: Apr 30, 2023
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Berbamine exerts an anti-oncogenic effect on pancreatic cancer.
May 08, 2022
Click here to read the entire abstract
Pubmed Data
: Anticancer Agents Med Chem. 2022 May 9. Epub 2022 May 9. PMID:
35579129
Article Published Date
: May 08, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berbamine
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Berberine inhibits tumour growth in vivo and in vitro through suppressing the lincROR-Wnt/β-catenin regulatory axis in colorectal cancer.
Sep 20, 2022
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2022 Sep 21. Epub 2022 Sep 21. PMID:
36130331
Article Published Date
: Sep 20, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells.
Feb 20, 2023
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2023 Feb 21:110408. Epub 2023 Feb 21. PMID:
36822301
Article Published Date
: Feb 20, 2023
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Cordycepin enhances radiosensitivity to induce apoptosis through cell cycle arrest, caspase pathway and ER stress in MA-10 mouse Leydig tumor cells.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Cancer Res. 2022 ;12(8):3601-3624. Epub 2022 Aug 15. PMID:
36119830
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cordyceps sinensis
Diseases
:
Cancers: All
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Radiosensitizer
[+]
Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells.
Sep 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Pharm Sin B. 2022 Oct ;12(10):3861-3876. Epub 2022 May 23. PMID:
36213538
Article Published Date
: Sep 30, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cucurbitacin B
Diseases
:
Melanoma
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Fucoxanthin inactivates the PI3K/Akt signaling pathway to mediate malignant biological behaviors of non-small cell lung cancer.
Jul 14, 2022
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2022 Jul 15:1-14. Epub 2022 Jul 15. PMID:
35838029
Article Published Date
: Jul 14, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Fucoxanthin
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
[+]
Glabridin inhibits urothelial bladder carcinoma cell growth.
Sep 12, 2022
Click here to read the entire abstract
Pubmed Data
: Chem Biol Drug Des. 2022 Sep 13. Epub 2022 Sep 13. PMID:
36098706
Article Published Date
: Sep 12, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flavonoids
,
Licorice
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma.
Nov 14, 2021
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2021 Nov 15 ;285:119961. Epub 2021 Sep 15. PMID:
34536497
Article Published Date
: Nov 14, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Amygdalin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton's Lymphoma.
Oct 24, 2022
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2022 Oct 25 ;302(Pt A):115849. Epub 2022 Oct 25. PMID:
36306933
Article Published Date
: Oct 24, 2022
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Moringa oleifera
Diseases
:
Lymphoma: Dalton's
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Pachymic acid inhibits growth and induces cell cycle arrest and apoptosis in gastric cancer SGC-7901 cells.
Jul 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2018 Aug ;16(2):2517-2524. Epub 2018 Jun 5. PMID:
30013646
Article Published Date
: Jul 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Poria cocos
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
This study demonstrated the successful inhibitory effect of AP-ZEONE on metastatic breast cancer cells.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2022 ;13:946161. Epub 2022 Sep 5. PMID:
36133807
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Apple Pectin
,
Zataria multiflora
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
,
Cancer Metastasis
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Essential Oils
[+]
"Antineoplaston AS2-1 showed an antimetastatic effect against post-operative lung metastases from colon cancer through G1 cell arrest and the subsequent induction of apoptosis."
Mar 01, 2005
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2005 Mar ;13(3):389-95. PMID:
15706406
Article Published Date
: Mar 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Antineoplaston AS2-1 (4:1 mixture of phenylacetic acid and phenylacetylglutamine)
Diseases
:
Cancer Metastasis
,
Colon Cancer
,
Lung Cancer: Metastatic
,
Post-Operative Lung Metastasis of Colon Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Cell cycle arrest
[+]
6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3β-cyclin D1 pathway in renal-cell carcinoma.
Dec 11, 2019
Click here to read the entire abstract
Pubmed Data
: Cancer Chemother Pharmacol. 2019 Dec 12. Epub 2019 Dec 12. PMID:
31832810
Article Published Date
: Dec 11, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Gingerol
Diseases
:
Kidney Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Cyclin D1 Down-Regulation
[+]
A combined mixture of medicinal mushrooms and P. ginseng root extracts could be an adjuvant treatment in human colorectal cancer.
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Sep ;38(3):1597-1604. Epub 2017 Jul 7. PMID:
28714027
Article Published Date
: Aug 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Medicinal Mushrooms
,
Panax Ginseng
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
A compound from Allium hirtifolium could inhibit growth of MCF-7 and MDA-MB-231 cells through cell cycle arrest and apoptosis induction.
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Sep ;93:117-129. Epub 2017 Jun 16. PMID:
28624423
Article Published Date
: Aug 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Shallot
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-Angiogenic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
A polyphenol-rich strawberry extract exerts important biological activities against a highly invasive breast cancer cell line.
Aug 07, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Aug 8 ;6:30917. Epub 2016 Aug 8. PMID:
27498973
Article Published Date
: Aug 07, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Polyphenols
,
Strawberry
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
Additional Keywords
:
Dose Response
[+]
Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro.
Feb 12, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Exp Clin Cancer Res. 2016 Feb 13 ;35:32. Epub 2016 Feb 13. PMID:
26872471
Article Published Date
: Feb 12, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Glioblastoma
Pharmacological Actions
:
Anti-Angiogenic
,
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Administration of quercetin at 15mg/kg body weight resulted in a ~70% reduction in tumor growth.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2016 ;11(6):e0157251. Epub 2016 Jun 10. PMID:
27285995
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Catechin
,
Quercetin
,
Resveratrol
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
[+]
Allomelanins suppress the tumor cell growth in vitro and in vivo.
Aug 01, 1997
Click here to read the entire abstract
Pubmed Data
: Cancer Biother Radiopharm. 1997 Aug;12(4):273-6. PMID:
10851475
Article Published Date
: Aug 01, 1997
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Polyphenols
Diseases
:
Lymphoma
Pharmacological Actions
:
Cell cycle arrest
Additional Keywords
:
Food Colors: Black
,
Food Colors: Purple
[+]
Aloe vera gel could suppress colitis-related colon carcinogenesis.
Sep 29, 2016
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2016 Sep 30 ;40:428-435. Epub 2016 Aug 30. PMID:
27697726
Article Published Date
: Sep 29, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Aloe Vera
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Anticarcinogenic Agents
,
Cell cycle arrest
,
Chemopreventive
,
NF-kappaB Inhibitor
[+]
An ethanol extract of Shitake (Lentinula elodes) selectively kills skin cancer cells in mice.
Mar 18, 2005
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2005 Mar 18;220(1):21-8. PMID:
15737684
Article Published Date
: Mar 18, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Shiitake Mushroom
Diseases
:
Skin Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Antiproliferative
,
Selective Cytotoxicity
[+]
An ethanol extract of sporoderm-broken spores of G. lucidum suppressed the growth of human lung cancer.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2016 Oct ;68(7):1151-60. Epub 2016 Aug 11. PMID:
27618151
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Reishi Mushroom
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
An extract of Litchi seed has potential for development into a safe and potent alternative therapy for prostate cancer patients.
Jan 29, 2017
Click here to read the entire abstract
Pubmed Data
: Sci Rep. 2017 Jan 30 ;7:41656. Epub 2017 Jan 30. PMID:
28134352
Article Published Date
: Jan 29, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Litchi
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
Additional Keywords
:
Anti-metastatic
,
Apoptotic
,
Cell cycle arrest
,
Litchi
,
P21 Activation
,
Plant Extracts
,
prostate cancer
[+]
Angelica polysaccharides inhibit the growth and promote the apoptosis of U251 glioma cells in vitro and in vivo.
Sep 14, 2017
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2017 Sep 15 ;33:21-27. Epub 2017 Jul 8. PMID:
28887916
Article Published Date
: Sep 14, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Angelica
Diseases
:
Glioma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Anthocyanin enriched sweet potatoes may protect against colorectal cancer by inducing cell-cycle arrest, antiproliferative, and apoptotic mechanisms.
Oct 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Nutr Food Res. 2013 Nov ;57(11):1908-17. Epub 2013 Jun 19. PMID:
23784800
Article Published Date
: Oct 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Anthocyanins
,
Fiber
,
Sweet Potato: Purple
Diseases
:
Colorectal Cancer
,
Colorectal Cancer: Prevention
Pharmacological Actions
:
Antineoplastic Agents
,
Antioxidants
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
,
Risk Reduction
[+]
Anti-cancer effect of cordycepin on FGF9-induced testicular tumorigenesis.
Nov 05, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2020 Nov 6 ;21(21). Epub 2020 Nov 6. PMID:
33172093
Article Published Date
: Nov 05, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Cordyceps sinensis
Diseases
:
Testicular Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Anticancer activities of parthenolide in primary effusion lymphoma preclinical models.
Jun 07, 2021
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2021 Jun 8. Epub 2021 Jun 8. PMID:
34101920
Article Published Date
: Jun 07, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Parthenolide
Diseases
:
Lymphoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Gene Expression Regulation
[+]
Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo.
Oct 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Biochim Biophys Sin (Shanghai). 2015 Nov ;47(11):925-31. Epub 2015 Sep 9. PMID:
26358321
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Lymphoma: B-Cell
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Antrodia camphorata extract, when combined with anti-tumor agents, showed adjuvant antiproliferative effects on multi-drug resistant hepatoma.
Aug 13, 2008
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2008 Aug 13;118(3):387-95. Epub 2008 May 7. PMID:
18571350
Article Published Date
: Aug 13, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Antrodia camphorata
Diseases
:
Cancers: Multi-Drug Resistant
,
Liver Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Cell cycle arrest
,
Cyclooxygenase 2 Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Apigenin may act as a chemotherapeutic agent for cervical cancer treatment.
Apr 03, 2022
Click here to read the entire abstract
Pubmed Data
: Cancers (Basel). 2022 Apr 4 ;14(7). Epub 2022 Apr 4. PMID:
35406599
Article Published Date
: Apr 03, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Apple total triterpenoid content induced apoptosis in MDA-MB-231 cells.
Sep 18, 2012
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2012 Sep 19 ;60(37):9430-6. Epub 2012 Sep 6. PMID:
22924395
Article Published Date
: Sep 18, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Apples
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
,
Colon Cancer
,
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
NF-kappaB Inhibitor
Additional Keywords
:
Dose Response
[+]
Artemisinin may be suitable for the treatment of gallbladder cancer.
Mar 29, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Mar 30. Epub 2016 Mar 30. PMID:
27035431
Article Published Date
: Mar 29, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Artemisinin
Diseases
:
Gallbladder Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
As mono-therapy the natural isoflavone genistein has a powerful therapeutic effect in vivo on A431 and Colo205 tumors.
Apr 06, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Apr 7. Epub 2016 Apr 7. PMID:
27070087
Article Published Date
: Apr 06, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Genistein
Diseases
:
Colon Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
[+]
Astaxanthin can inhibit proliferation and induce apoptosis and cell cycle arrest in mice H22 hepatoma cells in vitro and in vivo.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Med Sci Monit. 2016 ;22:2152-60. Epub 2016 Jun 23. PMID:
27333866
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Astaxanthin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Baicalein exerts potent S phase cell cycle arrest and pro-apoptotic effects in HCT-116 cells.
Oct 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Oncol. 2015 Nov ;47(5):1749-58. Epub 2015 Sep 18. PMID:
26398706
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Baicalein
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Microbiota
[+]
Baicalein may be a potent reagent for acute megakaryoblastic leukemia (AMKL) therapy.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Biosci. 2016 ;6:20. Epub 2016 Apr 1. PMID:
27042290
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Baicalein
Diseases
:
Leukemia
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Benzyl isothiocyanate induces apoptosis and inhibits tumor growth in canine mammary carcinoma.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Vet Sci. 2020 ;7:580530. Epub 2020 Nov 11. PMID:
33263014
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Benzyl isothiocyanate
Diseases
:
Cancers: Canine
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Benzyl isothiocyanate inhibits prostate cancer development.
Jan 21, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2016 02 22 ;17(2):264. Epub 2016 Feb 22. PMID:
26907265
Article Published Date
: Jan 21, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Benzyl isothiocyanate
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
Additional Keywords
:
Isothiocyanates
[+]
Berbamine suppresses cell viability and induces apoptosis in colorectal cancer.
Jan 31, 2018
Click here to read the entire abstract
Pubmed Data
: Cytotechnology. 2018 Feb ;70(1):321-329. Epub 2017 Sep 30. PMID:
28965196
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berbamine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
[+]
Berberine decreases the expression of EBNA1 and exhibits an antitumor effects against nasopharyngeal carcinoma.
Mar 31, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Apr ;37(4):2109-2120. Epub 2017 Mar 2. PMID:
28259949
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Berberine induced senescence of human glioblastoma cells.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Cancer Ther. 2015 Feb ;14(2):355-63. Epub 2014 Dec 12. PMID:
25504754
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Glioblastoma
Pharmacological Actions
:
Anti-Tumor
,
Apoptotic
,
Cell cycle arrest
,
Epidermal growth factor receptor (EGFR) inhibitor
[+]
Biobran may be a promising chemopreventive and chemotherapeutic agent for liver carcinogenesis.
May 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2020 Jun ;126:110064. Epub 2020 Apr 8. PMID:
32278271
Article Published Date
: May 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Modified Arabinoxylan Rice Bran (MGN-3)
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
,
Chemotherapeutic
[+]
Bromelain and acetylcysteine alone and in combination with gemcitabine inhibit subcutaneous deposits of pancreatic cancer after intraperitoneal injection.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Transl Res. 2021 ;13(12):13524-13539. Epub 2021 Dec 15. PMID:
35035694
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Bromelain
,
NAC (N-acetyl-L-cysteine)
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Chemotherapeutic Synergy: Gemcitabine
[+]
Cannabidiol enhanced the ability of THC to inhibit cell proliferation, induce cell cycle arrest and apoptosis.
Dec 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Cancer Ther. 2010 Jan ;9(1):180-9. Epub 2010 Jan 6. PMID:
20053780
Article Published Date
: Dec 31, 2009
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
,
Delta-tetrahydrocannabinol (THC)
Diseases
:
Cancer Metastasis
,
Glioblastoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Cannabinoid Receptors
,
Natural Substance Synergy
[+]
Cannabinoids inhibit the growth of melanoma cells but not of normal melanocytes.
Nov 30, 2006
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: FASEB J. 2006 Dec ;20(14):2633-5. Epub 2006 Oct 25. PMID:
17065222
Article Published Date
: Nov 30, 2006
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabinoids
,
Cannabinoids: Synthetic
Diseases
:
Melanoma
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-metastatic
,
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
Additional Keywords
:
Cannabinoid Receptors
,
Selective Cytotoxicity
[+]
CARI III exerted anti-cancer activity that is comparable to doxorubicin against melanoma in vivo, as well as in vitro.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2014 ;19(9):14383-95. Epub 2014 Sep 12. PMID:
25221864
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Antrodia camphorata
,
Chaga Mushroom (Inonotus obliquus)
,
Phellinus Linteus
,
Reishi Mushroom
Diseases
:
Melanoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Cyclin D1 Down-Regulation
,
P21 Activation
Additional Keywords
:
Plant Extracts
,
Superiority of Natural Substances versus Drugs
[+]
Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2.
Sep 27, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2018 Sep 28 ;9(76):34200-34212. Epub 2018 Feb 6. PMID:
30344937
Article Published Date
: Sep 27, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Carnosol
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Celastrol is a potential therapeutic agent for treating ovarian cancer.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Oncol. 2019 ;9:2. Epub 2019 Jan 28. PMID:
30746340
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Celastrol
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Chlorogenic acid inhibits human glioma U373 cell progression.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2021 ;15:1369-1383. Epub 2021 Mar 30. PMID:
33833498
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Chlorogenic Acid
Diseases
:
Glioma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Chrysin could be a potentially good candidate for future use in alternative anti-melanoma treatments.
Jan 14, 2018
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2018 Jan 15. Epub 2018 Jan 15. PMID:
29352974
Article Published Date
: Jan 14, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Chrysin
Diseases
:
Melanoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
[+]
Co-treatments with Uro-A decreased IC50 values for both 5-FU and 5'DFUR and additionally arrested the cell cycle at the G2/M phase.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2015 May ;6(5):1460-9. PMID:
25857357
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Ellagic Acid
,
Urolithin A
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Drug: 5-flourouracil
,
Metabolites
,
Microbiota
[+]
Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.
Mar 31, 2014
Click here to read the entire abstract
Pubmed Data
: Planta Med. 2014 Apr ;80(6):452-7. Epub 2014 Mar 31. PMID:
24687742
Article Published Date
: Mar 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Nobiletin
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Chemothapeutic Synergy: Paclitaxel
,
Drug: Carboplatin
,
Natural Substance/Drug Synergy
,
Plant Extracts
[+]
Combined broccoli sprouts and green tea polyphenols contribute to the prevention of estrogen receptor-negative mammary cancer.
Nov 12, 2020
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2020 Nov 13. Epub 2020 Nov 13. PMID:
33188406
Article Published Date
: Nov 12, 2020
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Broccoli Sprouts
,
Green Tea
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Combined curcumin and resveratrol reduces prostate cancer incidence in mice.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Int J Cancer. 2009 Jul 1;125(1):1-8. PMID:
19326431
Article Published Date
: Jul 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Resveratrol
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Natural Substance Synergy
,
Stilbenes
[+]
Cornus officinalis and Psoralea corylifolia extracts suppresses benign prostate hyperplasia.
May 01, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2019 May 2 ;24(9). Epub 2019 May 2. PMID:
31052610
Article Published Date
: May 01, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Babchi
,
Dogwood
Diseases
:
Prostatic Hyperplasia
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
Cucurbitacin B and cisplatin combination treatment may be a potentially useful therapeutic option for individuals diagnosed with laryngeal cancer.
Aug 31, 2010
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2010 Sep 1 ;641(1):15-22. Epub 2010 May 17. PMID:
20483353
Article Published Date
: Aug 31, 2010
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cucurbitacin B
Diseases
:
Laryngeal Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
[+]
Cucurbitacin B represents a promising therapeutic tool for the treatment of multiple myeloma.
Jul 12, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Jul 13. Epub 2016 Jul 13. PMID:
27418139
Article Published Date
: Jul 12, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cucurbitacin B
Diseases
:
Multiple Myeloma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Curcumin and boswellic acid induced upregulation of tumor suppressive miR-34a and downregulation of miR-27a in colorectal cancer cells.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Cancer Prev Res (Phila). 2015 May ;8(5):431-43. Epub 2015 Feb 23. PMID:
25712055
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Boswellia
,
Curcumin
Diseases
:
Colorectal Cancer
,
Colorectal Cancer: Prevention
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
,
MicroRNA modulator
Additional Keywords
:
Natural Substance Synergy
[+]
Curcumin and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Bioeng Biotechnol. 2020 ;8:50. Epub 2020 Feb 11. PMID:
32117930
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Piperine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemotherapeutic
[+]
Curcumin effectively inhibited the proliferation of melanoma cells in vitro and in vivo.
Nov 11, 2015
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2015 Nov 12. Epub 2015 Nov 12. PMID:
26573768
Article Published Date
: Nov 11, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
Diseases
:
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Autophagy Up-regulation
,
Cell cycle arrest
[+]
Curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 and PDE4 inhibition.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Thromb Haemost. 2015 Feb ;113(2):319-28. Epub 2014 Sep 18. PMID:
25230992
Article Published Date
: Jan 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Cancers: All
,
Melanoma
Pharmacological Actions
:
Anti-Angiogenic
,
Antiproliferative
,
Cell cycle arrest
,
Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords
:
Natural Substances Versus Drugs
[+]
Curcumin has anti-umorigenic and hormone-suppressive effects against pituitary tumors.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Endocr Relat Cancer. 2009 Dec;16(4):1339-50. Epub 2009 Sep 2. PMID:
19726538
Article Published Date
: Dec 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Pituitary Tumours
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Curcumin inhibits the proliferation of human oral cancer cells.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: Am J Chin Med. 2010;38(2):343-58. PMID:
20387230
Article Published Date
: Jan 01, 2010
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Oral Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Antineoplastic Agents
,
Cell cycle arrest
[+]
Curcumin inhibits tumorigenesis in mice.
Nov 01, 2009
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2009 Nov;23(11):1524-30. PMID:
9591190
Article Published Date
: Nov 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Tumors
Pharmacological Actions
:
Anti-Tumor
,
Anticarcinogenic Agents
,
Cell cycle arrest
[+]
Curcumin reduces pulmonary tumorigenesis in transgenic mice.
Jul 01, 2011
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2011 Jul ;55(7):1036-43. Epub 2011 May 2. PMID:
21538854
Article Published Date
: Jul 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Cell cycle arrest
,
Vascular Endothelial Growth Factor A Inhibitor
[+]
Curcumin suppresses the growth of malignant gliomas.
Feb 01, 2009
Click here to read the entire abstract
Pubmed Data
: Neurosurg Focus. 2009 Feb;26(2):E8. PMID:
17395690
Article Published Date
: Feb 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Glioma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
NF-kappaB Inhibitor
[+]
Curcumol exhibited time and concentration dependent anti-proliferative and apoptosis-inductive activities in SPC-A-1human lung adenocarcinoma cells.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Cancer Prev. 2015 ;16(6):2307-12. PMID:
25824755
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Curcumol
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Dose Response
,
Selective Cytotoxicity
[+]
Cyanidin 3-glucoside modulated cell cycle progression in liver precancerous lesion.
Apr 13, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: World J Gastroenterol. 2021 Apr 14 ;27(14):1435-1450. PMID:
33911466
Article Published Date
: Apr 13, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Anthocyanins
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
[+]
Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells.
May 31, 2018
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2018 Jun ;41(6):3485-3492. Epub 2018 Mar 5. PMID:
29512690
Article Published Date
: May 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Daidzein
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Daidzein inhibits choriocarcinoma proliferation by arresting cell cycle at G1 phase.
Sep 30, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Oct ;38(4):2518-2524. Epub 2017 Aug 28. PMID:
28849226
Article Published Date
: Sep 30, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Daidzein
Diseases
:
Choriocarcinoma
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Deuterium depleted water is a promising new anticancer agent with potential for future clinical application.
Jan 02, 2010
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2010 3 ;1(2):277-283. Epub 2010 Mar 1. PMID:
22993540
Article Published Date
: Jan 02, 2010
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Water: Deuterium Depleted
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anti-Tumor
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
[+]
Diallyl trisulfide suppresses tumor growth and potentiates cisplatin efficacy in gastric cancer treatment.
Mar 26, 2017
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2017 Mar 27. Epub 2017 Mar 27. PMID:
28344324
Article Published Date
: Mar 26, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Dimethyl trisulfide (DMTS)
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Apoptotic
,
Cell cycle arrest
,
Chemosensitizer
,
Chemotherapeutic Synergy: Cisplatin
,
Dimethyl trisulfide (DMTS)
,
gastric cancer
[+]
Dietary phytochemicals have a beneficial effect on benign prostatic hyperplasia prevention.
Nov 30, 2016
Click here to read the entire abstract
Pubmed Data
: Appl Physiol Nutr Metab. 2016 Dec ;41(12):1303-1310. Epub 2016 Sep 27. PMID:
27849354
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flaxseed
,
Lignans
Diseases
:
Prostatic Hyperplasia: Benign
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Cyclin D1 Down-Regulation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Dietary stearate prevents breast cancer carcinogenesis.
Aug 01, 2011
Click here to read the entire abstract
Pubmed Data
: Carcinogenesis. 2011 Aug ;32(8):1251-8. Epub 2011 May 17. PMID:
21586513
Article Published Date
: Aug 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Saturated fatty acids
,
Stearic Acid (stearate)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
[+]
Diosgenin was found to have efficient antitumor potential of human cholangiocarcinoma cells in vitro and in vivo.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Onco Targets Ther. 2019 ;12:9093-9104. Epub 2019 Nov 4. PMID:
31806994
Article Published Date
: Dec 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Diosgenin
Diseases
:
Cholangiocarcinoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Diosmin inhibits glioblastoma growth through inhibition of autophagic flux.
Sep 27, 2021
Click here to read the entire abstract
Pubmed Data
: Int J Mol Sci. 2021 Sep 28 ;22(19). Epub 2021 Sep 28. PMID:
34638796
Article Published Date
: Sep 27, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Diosmin
Diseases
:
Glioblastoma
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Eastern prickly pear extract may be a promising candidate for treating human cervical carcinoma.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2015 Jan ;18(1):31-44. PMID:
25379883
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Prickly Pear Cactus
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antioxidants
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Echinacea angustifolia extract is a potential candidate for breast cancer treatment.
Sep 21, 2020
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2020 Sep 22:1-19. Epub 2020 Sep 22. PMID:
32959676
Article Published Date
: Sep 21, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Echinacea
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Chemothapeutic Synergy: Paclitaxel
[+]
Effects of diallyl disulfide on the proliferation and apoptosis of epithelial ovarian cancer cells.
Feb 27, 2019
Click here to read the entire abstract
Pubmed Data
: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019 Feb 28 ;41(1):43-52. PMID:
30837041
Article Published Date
: Feb 27, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Garlic
,
Organosulfur Compounds
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
EGCG is a strong combination partner of gemcitabine reducing pancreatic cancer cell growth by suppressing glycolysis.
Oct 04, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancers (Basel). 2019 Oct 5 ;11(10). Epub 2019 Oct 5. PMID:
31590367
Article Published Date
: Oct 04, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Cancer Glycolysis
,
Chemotherapeutic Synergy: Gemcitabine
[+]
Emodin inhibits the proliferation of papillary thyroid carcinoma by activating AMPK .
Sep 30, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2021 Oct ;22(4):1075. Epub 2021 Jul 28. PMID:
34447468
Article Published Date
: Sep 30, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Emodin
Diseases
:
Thyroid Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Evodiamine has the potential to be a therapeutic medicine for hepatocellular carcinoma.
Mar 24, 2017
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2017 Mar 25 ;485(1):54-61. Epub 2017 Feb 9. PMID:
28189683
Article Published Date
: Mar 24, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Evodiamine
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Experimental anti-tumor effect of emodin in suspension - in situ hydrogels formed with self-assembling peptide.
Nov 30, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Deliv. 2021 Dec ;28(1):1810-1821. PMID:
34470553
Article Published Date
: Nov 30, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Emodin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Fish oil and selenium increase the chemotherapeutic efficacy of doxorubicin against triple-negative breast cancer.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Med Sci. 2022 ;19(14):2044-2057. Epub 2022 Nov 14. PMID:
36483592
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Fish Oil
,
Selenium
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
Gac fruit extract inhibits colon tumor growth.
Apr 01, 2005
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2005 Apr;26(4):881-9. PMID:
15753981
Article Published Date
: Apr 01, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Gac
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
Gac seed extract suppresses breast cancer growth by inducing cell cycle arrest and apoptosis.
Aug 04, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2015 Aug 5. Epub 2015 Aug 5. PMID:
26252798
Article Published Date
: Aug 04, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Gac
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Cyclin D1 Down-Regulation
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo.
Dec 04, 2014
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2014 Dec 5 ;224:149-56. Epub 2014 Nov 4. PMID:
25450235
Article Published Date
: Dec 04, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Squamous cell carcinoma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Bcl-xL down-regulation
,
Cell cycle arrest
[+]
Galangin, a compound found within Alpinia galanga, acts as a chemosensitizer in drug-resistant leukemia cells.
Jul 08, 2008
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2008 Jul 8;265(2):289-97. Epub 2008 Apr 18. PMID:
18374481
Article Published Date
: Jul 08, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Alpinia galanga
,
Flavonoids
Diseases
:
Cancers: Drug Resistant
,
Leukemia: Acute myelogenous leukemia (AML)
,
Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Chemosensitizer
[+]
Ganoderma extracts and spores oil possessed antitumor effects in vitro and in vivo.
Oct 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2016 Nov ;12(5):3571-3578. Epub 2016 Aug 29. PMID:
27900038
Article Published Date
: Oct 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Reishi Mushroom
Diseases
:
Cancers: All
Pharmacological Actions
:
Cell cycle arrest
,
Cyclin D1 Down-Regulation
,
Topoisomerase I inhibitor
,
Topoisomerase II Inhibitor
Additional Keywords
:
Dose Response
[+]
Ganoderma lucidum fruiting body extracts inhibit colorectal cancer.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Am J Transl Res. 2020 ;12(6):2675-2684. Epub 2020 Jun 15. PMID:
32655799
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Reishi Mushroom
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Autophagy Up-regulation
,
Cell cycle arrest
[+]
Genipin inhibits the growth of human bladder cancer cells.
Jan 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2018 Feb ;15(2):2619-2624. Epub 2017 Dec 11. PMID:
29434982
Article Published Date
: Jan 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Genipin
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Genistein may be a promising alternative adjuvant therapy for patients with esophageal carcinoma.
Apr 09, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Aging (Albany NY). 2020 Apr 10 ;12(7):6240-6259. Epub 2020 Apr 10. PMID:
32276266
Article Published Date
: Apr 09, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Genistein
Diseases
:
Esophageal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
STAT3 Inhibitor
[+]
Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells.
Sep 30, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2017 Oct ;51(4):1331-1342. Epub 2017 Sep 5. PMID:
28902363
Article Published Date
: Sep 30, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Ginsenoside 20(s)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells.
Dec 04, 2015
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2015 Dec 5 ;242:227-34. Epub 2015 Oct 19. PMID:
26482938
Article Published Date
: Dec 04, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Leukemia
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Histone deacetylase inhibitor
[+]
Ginsenoside Rh4 could be a potentially effective anti-tumor drug for breast cancer.
Mar 30, 2018
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 Mar 31. Epub 2018 Mar 31. PMID:
29596831
Article Published Date
: Mar 30, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Ginsenoside Rh4 induces apoptosis and autophagic cell death in colorectal cancer cells.
Dec 06, 2017
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2017 Dec 7 ;148:64-74. Epub 2017 Dec 7. PMID:
29225132
Article Published Date
: Dec 06, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Autophagy Up-regulation
,
Cell cycle arrest
[+]
Glucose-coated berberine nanodrug for glioma therapy through mitochondrial pathway.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Nanomedicine. 2020 ;15:7951-7965. Epub 2020 Oct 14. PMID:
33116511
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Glioma
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo.
Dec 31, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2012 ;7(8):e43064. Epub 2012 Aug 8. PMID:
22905202
Article Published Date
: Dec 31, 2011
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Grape Seed Extract
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
,
Proanthocyanidins
[+]
Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells.
Oct 15, 2006
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6194-202. PMID:
17062697
Article Published Date
: Oct 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Grape Seed Extract
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
Additional Keywords
:
Antineoplastic Agents
,
Antiproliferative
,
Plant Extracts
[+]
Green tea polyphenols and its constituent EGCG inhibits proliferation of human breast cancer cells in vitro and in vivo.
Jan 08, 2007
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2007 Jan 8;245(1-2):232-41. Epub 2006 Mar 6. PMID:
16519995
Article Published Date
: Jan 08, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
Flavonoids
,
Green Tea
,
Polyphenols
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Harmaline induces cell cycle arrest and apoptosis in SGC-7901 cells.
Dec 17, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2015 Dec 18 ;5:18613. Epub 2015 Dec 18. PMID:
26678950
Article Published Date
: Dec 17, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Syrian rue
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
gastric cancer
,
Syrian rue
[+]
Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy.
Jan 24, 2018
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2018 03 25 ;498(1):99-104. Epub 2018 Mar 1. PMID:
29501493
Article Published Date
: Jan 24, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Psychedelics:All
Diseases
:
Bone Cancer
,
Breast Cancer
,
Lung Cancer
,
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Autophagy Inhibitors
,
Cell cycle arrest
Additional Keywords
:
Selective Cytotoxicity
[+]
Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG-63 cells and xenograft mice models.
Oct 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2018 Nov ;16(5):6299-6306. Epub 2018 Sep 14. PMID:
30405765
Article Published Date
: Oct 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Hesperidin
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Higenamine enhances the antitumor effects of cucurbitacin B in breast cancer.
Sep 30, 2018
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2018 Oct ;40(4):2127-2136. Epub 2018 Aug 6. PMID:
30106443
Article Published Date
: Sep 30, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cucurbitacin B
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Natural Substance Synergy
[+]
Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.
Jan 04, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2017 10 5 ;8(10):e3089. Epub 2017 Oct 5. PMID:
28981104
Article Published Date
: Jan 04, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Phellinus Linteus
,
Polyphenols
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Cell cycle arrest
[+]
Honokiol induces apoptosis and autophagy in human osteosarcoma cells in vitro and in vivo.
Feb 05, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2018 Feb 6 ;9(2):157. Epub 2018 Feb 6. PMID:
29410403
Article Published Date
: Feb 05, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Honokiol
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Apoptotic
,
Autophagy Up-regulation
,
Cell cycle arrest
[+]
Huaier extract synergizes with tamoxifen to induce autophagy and apoptosis in ER-positive breast cancer cells.
Mar 22, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Mar 23. Epub 2016 Mar 23. PMID:
27027343
Article Published Date
: Mar 22, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Huaier (Trametes robiniophila murr)
Diseases
:
Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Autophagy Up-regulation
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
,
Synergy with Tamoxifen
[+]
In vitro and in vivo anti-cancer activity of dichloromethane fraction of Triticum aestivum sprouts.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2017 Dec ;96:120-128. Epub 2017 Sep 30. PMID:
28972884
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Wheat Grass
Diseases
:
Melanoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
In vivo antitumor activity of by-products of Passiflora edulis.
Jul 31, 2018
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2018 Aug ;118:557-565. Epub 2018 Jun 7. PMID:
29886231
Article Published Date
: Jul 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Passion Flower
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
In vivo experiments showed that Huaier significantly suppressed the tumor volume of SiHa cell xenografts.
Aug 31, 2015
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2015 Sep ;47(3):1054-60. Epub 2015 Jul 20. PMID:
26201539
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Huaier (Trametes robiniophila murr)
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma.
Sep 30, 2012
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2012 Oct ;51(10):761-70. Epub 2011 Aug 11. PMID:
21837756
Article Published Date
: Sep 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Oxidative Stress
,
Prostate Cancer
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Nrf2 activation
[+]
Indole-3-carbinol affects murine leukemia WEHI-3 cells both in vitro and in vivo.
Aug 07, 2012
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2012 Aug 8 ;60(31):7634-43. Epub 2012 Jul 26. PMID:
22775144
Article Published Date
: Aug 07, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Leukemia
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
Indole-3-carbinol inhibits nasopharyngeal carcinoma growth through cell cycle arrest in vivo and in vitro.
Dec 31, 2012
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2013 ;8(12):e82288. Epub 2013 Dec 16. PMID:
24358165
Article Published Date
: Dec 31, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Indole-3-carbinol would be effective for enhancing sensitivity of pancreatic cancer cells to gemcitabine.
Mar 31, 2013
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2013 Apr ;33(4):1473-81. PMID:
23564788
Article Published Date
: Mar 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Indole-3-Carbinol
Diseases
:
Cancers: Drug Resistant
,
Pancreatic Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemosensitizer
Additional Keywords
:
Chemotherapeutic Synergy: Gemcitabine
[+]
Induction of apoptosis of tumor cells by some potentiated homeopathic drugs.
May 31, 2012
Click here to read the entire abstract
Pubmed Data
: Integr Cancer Ther. 2012 Jun ;11(2):172-82. Epub 2011 Jul 19. PMID:
21771822
Article Published Date
: May 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Homeopathic Medicine: All
Diseases
:
Lymphoma
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
Additional Keywords
:
Phytotherapy
[+]
Inositol hexaphosphate inhibits the cell cycle of human breast and colon cancer cells.
Jul 01, 2001
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2001 Jul-Aug;21(4A):2393-403. PMID:
11724298
Article Published Date
: Jul 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Inositol Hexaphosphate
Diseases
:
Breast Cancer
,
Colon Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Cell cycle arrest
[+]
Isoliquiritigenin (ISL), a flavonoid chalcone that is present in licorice, shallot, and bean sprouts, has antitumorigenic activities in prostate tumor cells.
Feb 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2009 Feb;12(1):8-14. PMID:
19298190
Article Published Date
: Feb 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Beans: All
,
Flavonoids
,
Isoliquiritigenin
,
Licorice
,
Shallot
,
Sprouts
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Cell cycle arrest
,
Enzyme Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Isoquercitrin inhibits bladder cancer progression in vivo.
May 08, 2016
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2016 May 9. Epub 2016 May 9. PMID:
27177091
Article Published Date
: May 08, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Isoquercitrin
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest.
Aug 14, 2018
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2018 Aug 15 ;9(8):4500-4507. PMID:
30083664
Article Published Date
: Aug 14, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Licorice
Diseases
:
Glioma
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cell cycle arrest
[+]
Lipophilic grape seed proanthocyanidin exerts anti-cervical cancer effects.
Feb 18, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Antioxidants (Basel). 2022 Feb 19 ;11(2). Epub 2022 Feb 19. PMID:
35204304
Article Published Date
: Feb 18, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Grape Seed Extract
,
Proanthocyanidins
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bax/Bcl2 ratio: Increase
,
Cell cycle arrest
[+]
Lipophilic grape seed proanthocyanidin inhibited the growth of PC3-derived mouse xenografts by inhibiting tumor cell proliferation and inducing apoptosis.
Jan 08, 2019
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2019 Jan 9 ;67(1):229-235. Epub 2018 Dec 28. PMID:
30562012
Article Published Date
: Jan 08, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Grape Seed Extract
,
Proanthocyanidins
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Maitake mushroom and its active fraction inhibit hepatoma growth by inducing autophagy and apoptosis.
Mar 23, 2016
Click here to read the entire abstract
Pubmed Data
: Exp Biol Med (Maywood). 2016 Mar 24. Epub 2016 Mar 24. PMID:
27013543
Article Published Date
: Mar 23, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Maitake Mushroom
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Autophagy Up-regulation
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
Mangiferin may be considered a potential antineoplastic drug for the future treatment of cancer.
Mar 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2016 Apr ;13(4):3423-32. Epub 2016 Feb 29. PMID:
26935347
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Mangiferin
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
[+]
Medicinal mushroom Phellinus igniarius induced cell apoptosis in gastric cancer SGC-7901 through a mitochondria-dependent pathway.
May 31, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Jun ;102:18-25. Epub 2018 Mar 14. PMID:
29549725
Article Published Date
: May 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Medicinal Mushrooms
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
[+]
MicroRNA-6809-5p mediates luteolin-induced anticancer effects against hepatoma by targeting flotillin 1.
Oct 21, 2018
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2018 Oct 22 ;57:18-29. Epub 2018 Oct 22. PMID:
30668319
Article Published Date
: Oct 21, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Luteolin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
MicroRNA modulator
[+]
Mixed tocotrienols inhibit prostate carcinogenesis in mice.
Aug 01, 2010
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2010 Aug;62(6):789-94. PMID:
20661828
Article Published Date
: Aug 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Tocotrienols
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Apoptotic
,
Cell cycle arrest
[+]
Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3.
May 15, 2018
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2018 May 16. Epub 2018 May 16. PMID:
29769742
Article Published Date
: May 15, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Modified Citrus Pectin
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.
Nov 12, 2013
Click here to read the entire abstract
Pubmed Data
:
Life Sci.
2013 Nov 13;93(21):783-90. doi: 10.1016/j.lfs.2013.09.009. Epub 2013 Sep 15. PMID: 24044882
Article Published Date
: Nov 12, 2013
Study Type
: Insect Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Breast Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
[+]
Morusin has the potential to inhibit human breast cancer cell growth in vitro and in vivo.
Nov 03, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Exp Clin Cancer Res. 2015 Nov 4 ;34:137. Epub 2015 Nov 4. PMID:
26538209
Article Published Date
: Nov 03, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flavonoids
,
Mulberry
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Mulberry water extract enhanced the cytotoxicity of paclitaxel and induced severe G2/M arrest, mitotic catastrophe and subsequent apoptosis.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Sci Rep. 2016 ;6:20417. Epub 2016 Feb 3. PMID:
26838546
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Mulberry
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
Additional Keywords
:
Chemothapeutic Synergy: Paclitaxel
,
Plant Extracts
[+]
Murraya koenigii and its flavonoid compounds which act as proteasome inhibitors.
May 19, 2016
Click here to read the entire abstract
Pubmed Data
: Anticancer Agents Med Chem. 2016 May 20. Epub 2016 May 20. PMID:
27198988
Article Published Date
: May 19, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Curry Leaves
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Apoptotic
,
Cell cycle arrest
,
Proteasome Inhibitors
Additional Keywords
:
Dose Response
[+]
Neoisoliquiritin exerts tumor suppressive effects on prostate cancer by repressing androgen receptor activity.
Apr 30, 2021
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2021 May ;85:153514. Epub 2021 Feb 14. PMID:
33676083
Article Published Date
: Apr 30, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Licorice
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Nexrutine could be useful candidate agent for colon cancer chemoprevention and treatment.
Jul 31, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2016 Aug ;55(8):1262-74. Epub 2015 Aug 10. PMID:
26259065
Article Published Date
: Jul 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nexrutine (Phellodendrom)
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
,
Cyclooxygenase 2 Inhibitors
[+]
Noni leaf extract at 300mg/kg was more effective than Erlotinib for most of the parameters measured in this study.
Apr 21, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2016 Apr 22. Epub 2016 Apr 22. PMID:
27106908
Article Published Date
: Apr 21, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Noni leaf extract
Diseases
:
Cancer Metastasis
,
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Gene Expression Regulation
,
Plant Extracts
,
Superiority of Natural Substances versus Drugs
[+]
Oleanolic acid inhibits the growth of DU145, MCF-7, and U87 cancer cells.
May 28, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2018 May 29 ;9(41):26370-26386. Epub 2018 May 29. PMID:
29899865
Article Published Date
: May 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Oleanolic acid
Diseases
:
Breast Cancer
,
Glioblastoma
,
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
,
Tumor Suppressor Protein p53 Upregulation
[+]
Oridonin could exert anti-cancer effects on tumor growth in human glioma by inducing cell cycle arrest and eventual cell apoptosis.
Dec 31, 2013
Click here to read the entire abstract
Pubmed Data
: Cell Mol Biol (Noisy-le-grand). 2014 ;60(6):29-36. Epub 2014 Dec 30. PMID:
25553351
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Oridonin
Diseases
:
Glioma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Dose Response
[+]
Our results reveal Flavin7 (F7) had substantial tumour-suppression effects of 58 % and reduced tumour incidence by 24 % in this breast cancer model.
Apr 30, 2015
Click here to read the entire abstract
Pubmed Data
: Eur J Nutr. 2015 May 1. Epub 2015 May 1. PMID:
25930965
Article Published Date
: Apr 30, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Fruit Peel
,
Polyphenols
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Bax/Bcl2 Ratio: Decrease
,
Caspase-3 Activation
,
Cell cycle arrest
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Paeonia lactiflora inhibits bladder cancer growth.
Apr 25, 2011
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2011 Apr 26 ;135(1):162-72. Epub 2011 Mar 17. PMID:
21396995
Article Published Date
: Apr 25, 2011
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Peony
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Phytotherapy
[+]
Paeoniflorin inhibits growth of human colorectal carcinoma HT 29 cells in vitro and in vivo.
Apr 30, 2012
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2012 May ;50(5):1560-7. Epub 2012 Feb 2. PMID:
22326807
Article Published Date
: Apr 30, 2012
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Paeoniflorin
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Superiority of Natural Substances versus Drugs
[+]
Peanut sprout extracts cultivated with Fermented sawdust medium inhibits benign prostatic hyperplasia.
Mar 18, 2020
Click here to read the entire abstract
Pubmed Data
: World J Mens Health. 2020 Mar 19. Epub 2020 Mar 19. PMID:
32202087
Article Published Date
: Mar 18, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Peanut
Diseases
:
Prostatic Hyperplasia: Benign
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
Pinocembrin inhibits the proliferation and metastasis of breast cancer.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Oncol. 2021 ;11:661184. Epub 2021 Jul 16. PMID:
34336656
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Piperlongumine exhibits antitumor activity and has the potential for use as a chemotherapeutic agent against thyroid cancer.
Aug 23, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancers (Basel). 2021 Aug 24 ;13(17). Epub 2021 Aug 24. PMID:
34503074
Article Published Date
: Aug 23, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Piperlongumine
Diseases
:
Thyroid Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Polysaccharide extracted from Atractylodes macrocephala Koidz (PAMK) induce apoptosis in transplanted H22 cells in mice.
Sep 14, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2019 Sep 15 ;137:604-611. Epub 2019 Jun 19. PMID:
31226375
Article Published Date
: Sep 14, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Bai Zhu
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Polysaccharides
[+]
Preclinical evaluation of antitumoral and cytotoxic properties of Viscum album fraxini extract on pediatric tumor cells.
Sep 30, 2019
Click here to read the entire abstract
Pubmed Data
: Planta Med. 2019 Oct ;85(14-15):1150-1159. Epub 2019 Oct 7. PMID:
31590196
Article Published Date
: Sep 30, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Mistletoe
Diseases
:
Neuroblastoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Propolis contains a compound which inhibits triple negative breast cancer in the animal model.
Sep 01, 2011
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2011 Sep 1;308(1):43-53. Epub 2011 May 13. PMID:
21570765
Article Published Date
: Sep 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Bee Propolis
,
Caffeic acid phenethyl ester
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-Angiogenic
,
Apoptotic
,
Cell cycle arrest
,
NF-kappaB Inhibitor
[+]
Protective effect of the polysaccharides from Taraxacum mongolicum leaf by modulating the p53 signaling pathway in H22 tumor.
Oct 23, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Foods. 2022 Oct 24 ;11(21). Epub 2022 Oct 24. PMID:
36359953
Article Published Date
: Oct 23, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Dandelion
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Bcl-xL down-regulation
,
Cell cycle arrest
,
Immunomodulatory
Additional Keywords
:
Polysaccharides
[+]
Protein phosphatase 2A mediates diosmin p53 activation to block hepato-cellular carcinoma HA22T cell proliferation and tumor growth.
Apr 30, 2012
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2012 May ;50(5):1802-10. Epub 2012 Jan 25. PMID:
22289577
Article Published Date
: Apr 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Diosmin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
Protein regulator of cytokinesis 1 is a novel downstream target of piperlongumine in gastric cancer.
Jun 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Mol Med. 2017 Jul ;21(7):1329-1341. Epub 2017 Feb 12. PMID:
28190297
Article Published Date
: Jun 30, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Piperlongumine
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Proteomic analysis of the protective effect of eriodictyol on benzo(a)pyrene-induced caco-2 cytotoxicity.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Nutr. 2022 ;9:839364. Epub 2022 Mar 3. PMID:
35308267
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Eriodictyol
Diseases
:
Benzo[a]pyrene-induced Toxicity
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Gastroprotective
Problem Substances
:
Benzo(a)pyrene
[+]
Prunella vulgaris has potential as a lung cancer chemopreventive agent.
Dec 31, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Cancer Prev. 2010 ;11(5):1355-8. PMID:
21198292
Article Published Date
: Dec 31, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Prunella vulgaris
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
Additional Keywords
:
Phytotherapy
,
Plant Extracts
Problem Substances
:
Benzo(a)pyrene
[+]
Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis.
Jul 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2019 Aug ;18(2):1631-1640. Epub 2019 Jun 19. PMID:
31423230
Article Published Date
: Jul 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Pterostilbene
Diseases
:
Lung Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
P21 Activation
[+]
Resveratrol may have therapeutic value in bone marrow diseases such as Fanconi anemia.
Dec 09, 2010
Click here to read the entire abstract
Pubmed Data
: Blood. 2010 Dec 9;116(24):5140-8. Epub 2010 Sep 8. PMID:
20826722
Article Published Date
: Dec 09, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
Diseases
:
Bone Marrow Diseases
,
Fanconi Anemia
,
Hematopoietic Diseases
Pharmacological Actions
:
Antioxidants
,
Cell cycle arrest
Additional Keywords
:
Stilbenes
[+]
Resveratrol reverses the proliferative phenotype of obese adipose tissue to prevent breast cancer proliferation.
Jan 01, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(9):e0183897. Epub 2017 Sep 5. PMID:
28873415
Article Published Date
: Jan 01, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol
,
Stilbenes
Diseases
:
Breast Cancer
,
Obesity
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
[+]
Root extract of Prunella vulgaris inhibits in vitro and in vivo carcinogenesis in MCF-5 human breast carcinoma.
Feb 28, 2019
Click here to read the entire abstract
Pubmed Data
: J BUON. 2019 Mar-Apr;24(2):549-554. PMID:
31128004
Article Published Date
: Feb 28, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Prunella vulgaris
Diseases
:
Breast Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anticarcinogenic Agents
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
Additional Keywords
:
Plant Extracts
[+]
Rosmarinic acid inhibits proliferation and invasion of hepatocellular carcinoma cells.
Sep 17, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2019 Sep 18 ;120:109443. Epub 2019 Sep 18. PMID:
31541884
Article Published Date
: Sep 17, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Rosmarinic acid
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Shikonin induces apoptosis and G0/G1 phase arrest of gallbladder cancer cells.
Nov 30, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Dec ;38(6):3473-3480. Epub 2017 Oct 17. PMID:
29039581
Article Published Date
: Nov 30, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Shikonin
Diseases
:
Gallbladder Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Dose Response
[+]
Shikonin inhibits cancer through P21 upregulation and apoptosis induction.
Dec 31, 2019
Click here to read the entire abstract
Pubmed Data
: Front Pharmacol. 2020 ;11:861. Epub 2020 Jun 9. PMID:
32581812
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Shikonin
Diseases
:
Cancers: All
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Autophagy Up-regulation
,
Cell cycle arrest
,
P21 Activation
[+]
Silibinin inhibits human hepatocellular carcinoma xenografts in nude mice.
Apr 28, 2009
Click here to read the entire abstract
Pubmed Data
: World J Gastroenterol. 2009 Apr 28 ;15(16):1943-50. PMID:
19399925
Article Published Date
: Apr 28, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Milk Thistle
,
Silibinin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
Cell cycle arrest
,
Superoxide Dismutase Up-regulation
[+]
Solanum nigrum exhibits anticancer activity against cervical cancer in mice.
Nov 01, 2009
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2009 Nov;23(11):1524-30. PMID:
19449342
Article Published Date
: Nov 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Solanum nigrum (black nightshade)
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
Soy isoflavones induce programmed cell death and cell cycle arrest in human hepatoma cells.
Jan 01, 2003
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2003;45(1):113-23. PMID:
12791511
Article Published Date
: Jan 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Isoflavones
,
Soy
Diseases
:
Hepatoma
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Soy phytochemicals prevent growth and metastasis of bladder cancer in mice.
Feb 01, 2006
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2006 Feb 1;66(3):1851-8. PMID:
16452247
Article Published Date
: Feb 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Daidzein
,
Genistein
,
Isoflavones
Diseases
:
Bladder Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
,
Insulin-Like Growth Factor Inhibition/Downregulation
,
NF-kappaB Inhibitor
[+]
Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice.
Sep 01, 1999
Click here to read the entire abstract
Pubmed Data
: J Nutr. 1999 Sep;129(9):1628-35. PMID:
10460196
Article Published Date
: Sep 01, 1999
Study Type
: Animal Study
Additional Links
Substances
:
Daidzein
,
Genistein
,
Soy Protein
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Antineoplastic Agents
,
Apoptotic
,
Cell cycle arrest
[+]
Spirulina has a chemoprevention effect on rat liver toxicity and carcinogenesis.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Int J Biol Sci. 2009 ;5(4):377-87. Epub 2009 Jun 2. PMID:
19521547
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Spirulina
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antioxidants
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemopreventive
[+]
Statins exhibit complex immunomodulatory properties, including T cell-mediated tumour immune tolerance.
Aug 01, 2010
Click here to read the entire abstract
Pubmed Data
: Clin Exp Immunol. 2010 Aug ;161(2):298-305. Epub 2010 May 18. PMID:
20491794
Article Published Date
: Aug 01, 2010
Study Type
: Animal Study
Additional Links
Diseases
:
Immune Disorders: Low Immune Function
,
Tumors
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Interleukin-10 downregulation
Problem Substances
:
Simvastatin
Adverse Pharmacological Actions
:
Immunosuppressive
[+]
Structure-activity insights of harmine targeting DNA, ROS inducing cytotoxicity with PARP mediated apoptosis against cervical cancer, anti-biofilm formation.
Jan 21, 2021
Click here to read the entire abstract
Pubmed Data
: J Biomol Struct Dyn. 2021 Jan 22:1-23. Epub 2021 Jan 22. PMID:
33480316
Article Published Date
: Jan 21, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Harmine
Diseases
:
Cervical Cancer
,
Staphylococcus aureus infection
Pharmacological Actions
:
Anti-Bacterial Agents
,
Anti-Inflammatory Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Bacterial Infections: Resistance/Biofilm Formation
[+]
Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.
Nov 01, 2007
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2007 Nov;18(5):1263-8. PMID:
17914583
Article Published Date
: Nov 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Anticarcinogenic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Sulforaphane induces cell cycle arrest and programmed cell death in human lung cancer cells and retards growth of human lung cancer tumors in a xenograft animal model.
Oct 15, 2008
Click here to read the entire abstract
Pubmed Data
: J Nat Prod. 2008 Oct 15. Epub 2008 Oct 15. PMID:
18855447
Article Published Date
: Oct 15, 2008
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Cell cycle arrest
[+]
Sulforaphane inhibits oral cancer cell growth in vitro and in an animal model.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: J Clin Biochem Nutr. 2010 Jan;46(1):60-7. Epub 2009 Dec 29. PMID:
20104266
Article Published Date
: Jan 01, 2010
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Oral Cancer
Pharmacological Actions
:
Cell cycle arrest
[+]
Sulforaphane inhibits vestibular schwannoma growth in vitro and in vivo.
Nov 01, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Nov 2 ;6:36215. Epub 2016 Aug 2. PMID:
27805058
Article Published Date
: Nov 01, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Schwannoma: Vestibular
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Sumac demonstrates oncostatic activity in the therapeutic and preventive model of breast carcinoma.
Dec 25, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2020 Dec 26 ;22(1). Epub 2020 Dec 26. PMID:
33375383
Article Published Date
: Dec 25, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Sumac
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer.
Nov 04, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Nanobiotechnology. 2022 Nov 5 ;20(1):471. Epub 2022 Nov 5. PMID:
36335352
Article Published Date
: Nov 04, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Artesunate
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors.
Jun 14, 2005
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Cancer Res. 2005 Jun 15 ;11(12):4601-9. PMID:
15958646
Article Published Date
: Jun 14, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Nordihydroguaiaretic acid (NDGA)
Diseases
:
Cancers: All
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Tanshinone IIA inhibits human prostate cancer cells growth.
Nov 30, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Prostate Cancer Prostatic Dis. 2013 Dec ;16(4):315-22. Epub 2013 Sep 17. PMID:
24042854
Article Published Date
: Nov 30, 2013
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Tanshinone IIA
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
Tea polyphenols induce S phase arrest and apoptosis in gallbladder cancer cells.
Feb 28, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Braz J Med Biol Res. 2018 Mar 1 ;51(4):e6891. Epub 2018 Mar 1. PMID:
29513793
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Polyphenols
Diseases
:
Gallbladder Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Gallbladder Cancer
,
POLYPHENOLS
[+]
Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo.
Jul 14, 2001
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancer Res. 2001 Jul 15 ;61(14):5499-504. PMID:
11454698
Article Published Date
: Jul 14, 2001
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Nordihydroguaiaretic acid (NDGA)
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
[+]
Tetrahydrocurcumin inhibited tumor growth and tumor progression in CaSki-implanted female nude mice.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2016 ;2016:1781208. Epub 2016 Jan 4. PMID:
26881213
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Tetrahydrocurcumin
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
The anti-osteosarcoma effect from panax notoginseng saponins.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cancer. 2021 ;12(21):6383-6392. Epub 2021 Aug 30. PMID:
34659528
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Panax Notoginseng
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
The current study clearly indicates that 6-shogaol can be exploited for the prevention and treatment of NSCLC.
Feb 28, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Carcinogenesis. 2014 Mar ;35(3):683-91. Epub 2013 Nov 26. PMID:
24282290
Article Published Date
: Feb 28, 2014
Study Type
: Animal Study
Additional Links
Substances
:
6-Shogaol
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer: Prevention
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Caspase-3 Activation
,
Cell cycle arrest
,
Chemopreventive
,
STAT3 Inhibitor
[+]
The ethanolic extract of black pepper has cytotoxic and antiproliferative effect on MCF-7 cells and antitumor effect in vivo.
May 09, 2016
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2016 May 10. Epub 2016 May 10. PMID:
27178634
Article Published Date
: May 09, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Black Pepper
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
The growth of subcutaneous melanoma was significantly inhibited in mice treated with cucurbitacin B.
Jun 30, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Biochim Biophys Sin (Shanghai). 2011 Jul ;43(7):556-67. Epub 2011 Jun 2. PMID:
21642275
Article Published Date
: Jun 30, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Cucurbitacin B
Diseases
:
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
[+]
The Maya healing plant Anthurium schlechtendalii exhibits strong in vitro anticancer activity against promyelocytic leukemia.
Oct 01, 2009
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2009 Oct;24(4):513-21. PMID:
19724892
Article Published Date
: Oct 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Anthurium schlechtendalii
Diseases
:
Promyelocytic leukemia
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
The present study suggests that 6-shogaol is a potential novel candidate for anti-HNSCCs therapy.
Dec 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Med Sci. 2023 ;20(2):238-246. Epub 2023 Jan 22. PMID:
36794162
Article Published Date
: Dec 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
6-Shogaol
Diseases
:
Head and Neck Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
[+]
The preventive effects of hyperoside on lung cancer in vitro.
Sep 30, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Oct ;83:381-391. Epub 2016 Jul 14. PMID:
27419887
Article Published Date
: Sep 30, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Cancer Metastasis
,
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
NF-kappaB Inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
The results of this study indicate that dry olive leaf extract possesses strong antimelanoma potential.
Apr 14, 2011
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Cancer. 2011 Apr 15 ;128(8):1955-65. PMID:
20568104
Article Published Date
: Apr 14, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Olive leaf extract
Diseases
:
Chemotherapy-Induced Toxicity
,
Malignant Melanoma
,
Melanoma
,
Skin Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Chemotherapeutic
Additional Keywords
:
Natural Substance/Drug Antagonism
,
Natural Substance/Drug Synergy
,
Plant Leaves
,
Temozolomide
Problem Substances
:
Cisplatin
,
Doxorubicin
,
Paclitaxel
[+]
The structural characteristics of an acid-soluble polysaccharide from Grifola frondosa and its antitumor effects on H22-bearing mice.
May 09, 2020
Click here to read the entire abstract
Pubmed Data
: Int J Biol Macromol. 2020 May 10. Epub 2020 May 10. PMID:
32437807
Article Published Date
: May 09, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Maitake Mushroom
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Immunomodulatory
Additional Keywords
:
Polysaccharides
[+]
The unexplored wound healing activity of Urtica dioica L. extract.
Oct 14, 2021
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Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2021 Oct 15 ;26(20). Epub 2021 Oct 15. PMID:
34684829
Article Published Date
: Oct 14, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Nettle
Diseases
:
Wound Healing
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Antiproliferative
,
Cell cycle arrest
Additional Keywords
:
Plant Extracts
[+]
These findings identify Magnolol as a promising candidate with anti-microtubule polymerization activity for NSCLC treatment.
Jul 25, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2017 Jul 26 ;42(5):1789-1801. Epub 2017 Jul 26. PMID:
28746938
Article Published Date
: Jul 25, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Magnolol
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Tumor Suppressor Protein p53 Upregulation
[+]
These findings indicate that formononetin exhibits significant anti-cancer effects in multiple myeloma.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2018 09 1 ;431:123-141. Epub 2018 May 29. PMID:
29857127
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Formononetin
Diseases
:
Multiple Myeloma
,
Oxidative Stress
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
STAT3 Inhibitor
[+]
These findings provide novel proofs on the effects of um-palmitoylethanolamide in colon carcinogenesis.
Apr 15, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cancers (Basel). 2021 Apr 16 ;13(8). Epub 2021 Apr 16. PMID:
33923494
Article Published Date
: Apr 15, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Palmitoylethanolamide
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
[+]
These results demonstrate the potential therapeutic efficacy of Cucurbitacin D against cervical cancer.
Nov 07, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Nov 8 ;6:36594. Epub 2016 Nov 8. PMID:
27824155
Article Published Date
: Nov 07, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cucurbitacin D
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
MicroRNA modulator
[+]
These results indicate the potential of curcumol in the prevention of colon cancer carcinogenesis.
Jan 09, 2018
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2018 Jan 10 ;210:1-9. Epub 2017 Jul 4. PMID:
28684297
Article Published Date
: Jan 09, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumol
Diseases
:
Colon Cancer
Pharmacological Actions
:
Antiproliferative
,
Cell cycle arrest
,
Chemopreventive
,
Cyclin D1 Down-Regulation
,
P21 Activation
[+]
These results indicate the use of formononetin in the prevention of breast cancer carcinogenesis.
Aug 31, 2011
Click here to read the entire abstract
Pubmed Data
: Horm Metab Res. 2011 Sep ;43(10):681-6. Epub 2011 Sep 19. PMID:
21932171
Article Published Date
: Aug 31, 2011
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
: