Chondroprotective

Name	AC	CK
Curcumin	3	12
Flavonoids	8	11
Broccoli	1	10
Grape	1	10
Isothiocyanates	1	10
Olive leaf extract	1	10
Polyphenols	1	10
Ginsenosides	3	9
Pomegranate	3	8
Salvia miltiorrhiza	4	8
Icariin	6	7
Vitamin C	2	6
Delphinidin	1	5
Apigenin	2	4
Apple Polyphenols	2	4
Puerarin	2	4
Wogonin	3	4
Bromelain	1	3
Ginkgo biloba	2	3
Melatonin	2	3
Quercetin	2	3
Tanshinone IIA	2	3
Turmeric	2	3
Vitamin D	2	3
Asiatic Acid	1	2
Cannabis	1	2
Carnosine	1	2
Celadrin	1	2
Cissus quadrangularis	1	2
Dogwood	1	2
Echinacea	1	2
Emodin	1	2
Epicatechin	1	2
Eugenol	1	2
Ferulic acid	1	2
Hydrogen Water	1	2
Indigo Naturalis	1	2
Isoflavones	1	2
Nigella sativa (aka Black Seed)	1	2
Noni	1	2
P-Coumaric Acid	1	2
Phellinus Linteus	1	2
Pine Bark Extract	1	2
Piperlongumine	1	2
Safranal	1	2
Sesamol	1	2
Tamarind	1	2
Thistle	1	2
Tomatidine	1	2
Tripterygium wilfordii	1	2
Vitexins	1	2
Andrographolide	1	1
Artesunate	1	1
Astragaloside	1	1
Baicalein	1	1
Bee Propolis	1	1
Beta-Caryophyllene	1	1
Chlorella (Algae)	1	1
Diosmin	1	1
Fisetin	1	1
Frankincense	1	1
Genipin	1	1
Glucosamine	1	1
Gynostemma	1	1
Hesperidin	1	1
Hydroxytyrosol	1	1
Iodine	1	1
Liquiritigenin	1	1
Lycopene	1	1
Myricetin	1	1
Olive	1	1
Paeoniflorin	1	1
Panax Notoginseng	1	1
Punicalagin	1	1
Red Clover	1	1
Reishi Mushroom	1	1
Resveratrol	1	1
Selenium	1	1
Shikonin	1	1
Stigmasterol	1	1
Tocotrienols	1	1
Urolithin A	1	1
Vitamin K2	1	1

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Chondroprotective properties of human-enriched serum following polyphenol extract absorption.Dec 15, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Dec 16 ;11(12). Epub 2019 Dec 16. PMID: 31888255

Article Published Date : Dec 15, 2019

Study Type : Human Study

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Substances : Grape, Olive leaf extract, Polyphenols

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts, Proanthocyanidins

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Pubmed Data : Biochem Biophys Res Commun. 2022 May 7 ;614:120-124. Epub 2022 May 7. PMID: 35580540

Article Published Date : May 06, 2022

Study Type : Animal Study

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Substances : Apple Polyphenols

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective

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Apple procyanidins are promising food components that inhibit osteoarthritis progression.May 07, 2018

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Pubmed Data : Front Pharmacol. 2022 ;13:783506. Epub 2022 Feb 23. PMID: 35281931

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective

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Carnosine had chondroprotective effects on type 2 diabetes mellitus-induced osteoarthritis.Dec 31, 2017

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Pubmed Data : Drug Des Devel Ther. 2015 ;9:2927-40. Epub 2015 Jun 5. PMID: 26089642

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Cissus quadrangularis

Diseases : Inflammation, Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation

Additional Keywords : Plant Extracts

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Dihydrotanshinone I protects human chondrocytes and alleviates damage from spontaneous osteoarthritis.Dec 03, 2023

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Pubmed Data : Am J Phys Med Rehabil. 2004 Oct ;83(10):758-65. PMID: 15385784

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Puerarin plays a protective role in chondrocytes by activating Beclin1-dependent autophagy.Feb 23, 2021

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Pubmed Data : Biosci Biotechnol Biochem. 2021 Feb 24 ;85(3):621-625. PMID: 33624774

Article Published Date : Feb 23, 2021

Study Type : Animal Study

Additional Links

Substances : Puerarin

Diseases : Osteoarthritis

Pharmacological Actions : Chondroprotective

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Quercetin exerts chondroprotective effects.Jul 06, 2024

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Pubmed Data : Int J Mol Sci. 2024 Jul 7 ;25(13). Epub 2024 Jul 7. PMID: 39000568

Article Published Date : Jul 06, 2024

Study Type : Animal Study

Additional Links

Substances : Quercetin

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Matrix metalloproteinase-3 (MMP-3) inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Safranal can potentially prevent osteoarthritis development. Aug 09, 2022

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Pubmed Data : J Agric Food Chem. 2022 Aug 10 ;70(31):9748-9759. Epub 2022 Jul 28. PMID: 35899925

Article Published Date : Aug 09, 2022

Study Type : Animal Study

Additional Links

Substances : Safranal

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Apoptotic, Chondroprotective, SIRT1 Activator

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Pubmed Data : Int J Mol Sci. 2016 Dec 9 ;17(12). Epub 2016 Dec 9. PMID: 27941690

Article Published Date : Dec 08, 2016

Study Type : Animal Study

Additional Links

Substances : Pine Bark Extract

Diseases : Osteoarthritis

Pharmacological Actions : Chondroprotective, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Chondroprotective, osteoarthritis, pine bark extract, Procyanidins, Vascular Endothelial Growth Factor Inhibitors

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These results show that the chondroprotective effects of wogonin are produced by its regulation of the gene expression.Aug 31, 2015

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Pubmed Data : Biomol Ther (Seoul). 2015 Sep ;23(5):442-8. Epub 2015 Sep 1. PMID: 26336584

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Pubmed Data : Food Funct. 2018 Nov 14 ;9(11):5740-5749. PMID: 30321247

Article Published Date : Nov 13, 2018

Study Type : Animal Study, In Vitro Study

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Substances : Vitexins

Diseases : Inflammation, Osteoarthritis

Pharmacological Actions : Anti-Apoptotic, Chondroprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes.Dec 31, 2019

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Pubmed Data : Phytother Res. 2021 Jul ;35(7):4032-4045. Epub 2021 Apr 15. PMID: 33860572

Article Published Date : Jun 30, 2021

Study Type : In Vitro Study

Additional Links

Substances : Lycopene

Diseases : Osteoarthritis, Oxidative Stress

Pharmacological Actions : Antioxidants, Autophagy Up-regulation, Chondroprotective

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Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair.Dec 31, 2017

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Pubmed Data : J Inflamm (Lond). 2018 ;15:14. Epub 2018 Jul 20. PMID: 30038551

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Pubmed Data : Adv Clin Exp Med. 2018 Jul ;27(7):913-920. PMID: 29905408

Article Published Date : Jun 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective

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Gypenoside inhibits interleukin-1β-induced inflammatory response in human osteoarthritis chondrocytes.Aug 31, 2017

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Pubmed Data : J Biochem Mol Toxicol. 2017 Sep ;31(9). Epub 2017 Apr 19. PMID: 28422402

Article Published Date : Aug 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Gynostemma

Diseases : Osteoarthritis

Pharmacological Actions : Chondroprotective, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, NF-kappaB Inhibitor

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Myricetin restores autophagy to attenuate lumbar intervertebral disk degeneration.Jun 05, 2024

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Pubmed Data : Biochem Genet. 2024 Jun 6. Epub 2024 Jun 6. PMID: 38842745

Article Published Date : Jun 05, 2024

Study Type : In Vitro Study

Additional Links

Substances : Myricetin

Diseases : Degenerative Disk Disease

Pharmacological Actions : Chondroprotective

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Pubmed Data : J Orthop Surg Res. 2022 Sep 5 ;17(1):406. Epub 2022 Sep 5. PMID: 36064420

Article Published Date : Sep 04, 2022

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Osteoarthritis

Pharmacological Actions : Chondroprotective, SIRT1 Activator

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Sesamol has chondroprotective properties.May 11, 2011

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Pubmed Data : Biomed Pharmacother. 2024 Jun ;175:116697. Epub 2024 May 17. PMID: 38759289

Article Published Date : May 31, 2024

Study Type : In Vitro Study

Additional Links

Substances : Vitamin K2

Diseases : Osteoarthritis

Pharmacological Actions : Chondroprotective, Osteoprotective

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Wogonin intercalates with genomic DNA and exhibits protective effects in IL-1β stimulated osteoarthritis chondrocytes.Aug 24, 2017

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Pubmed Data : Chem Biol Interact. 2017 Aug 25 ;274:13-23. Epub 2017 Jul 5. PMID: 28688942

Article Published Date : Aug 24, 2017

Study Type : In Vitro Study

Additional Links

Substances : Wogonin

Diseases : Osteoarthritis

Pharmacological Actions : Chondroprotective, Interleukin-1 beta downregulation

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View the Evidence: 114 Abstracts with Chondroprotective Research

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Chondroprotective properties of human-enriched serum following polyphenol extract absorption.Dec 15, 2019

Curcumin can effectively decrease the pathological results of osteoarthritis.Apr 21, 2022

Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint.Jan 12, 2017

Laser biostimulation can be an effective strategy in the therapy of the invertebral disks.Dec 29, 2016

A Polyphenol-rich pomegranate fruit extract suppresses NF-κB and IL-6 expression.Mar 08, 2017

Cytoprotective effects of delphinidin for human chondrocytes against oxidative stress through activation of autophagy.Jan 18, 2020

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Vitamin C was able to markedly protect the condrocytes against the toxic effects of local anesthetics - ropivacaine, bupivacaine and lidocaine.Dec 31, 2015

Bromelain extract exerts antiarthritic effects via chondroprotection.Oct 22, 2021

2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside can be considered as a potential therapeutic for the treatment of postmenopausal osteoporosis.Aug 27, 2018

A blend of Tamarindus indica and Curcuma longa extracts alleviates osteoarthritic pain and joint inflammation.May 23, 2023

Active Vitamin D activates chondrocyte autophagy to reduce osteoarthritis.Dec 08, 2019

Anti-apoptosis and autophagy effects of melatonin protect rat chondrocytes.Jan 11, 2021

Apigenin can regulate the gene expression, secretion, and activity of MMP-3, by directly acting on articular chondrocytes.Feb 29, 2016

Apple polyphenols exhibits chondroprotective changes of synovium and prevents knee osteoarthritis.May 06, 2022

Apple procyanidins are promising food components that inhibit osteoarthritis progression.May 07, 2018

Asiatic acid ameliorates obesity-related osteoarthritis by inhibiting myeloid differentiation protein-2.Jun 23, 2020

Baicalin ameliorates cartilage injury in rats with osteoarthritis.Aug 30, 2024

Bilobalide exerts anti-inflammatory effects on chondrocytes.Dec 31, 2021

Carnosine had chondroprotective effects on type 2 diabetes mellitus-induced osteoarthritis.Dec 31, 2017

Chondroprotective and antiarthritic effects of galangin in osteoarthritis.Sep 04, 2021

Chondroprotective effect of Nigella sativa oil in the early stages of osteoarthritis.Aug 31, 2019

Cirsium japonicum var. maackii and apigenin block Hif-2α-induced osteoarthritic cartilage destruction.Dec 31, 2018

Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration.Dec 31, 2014

Dihydrotanshinone I protects human chondrocytes and alleviates damage from spontaneous osteoarthritis.Dec 03, 2023

Distinctive therapeutic effects of non-euphorigenic cannabis extracts in osteoarthritis.Aug 21, 2022

Echinacoside upregulates Sirt1 to suppress endoplasmic reticulum stress and inhibit extracellular matrix degradation.Dec 31, 2020

Effects of helium-neon laser on levels of stress protein and arthritic histopathology in experimental osteoarthritis.Sep 30, 2004

Effects of photobiomodulation therapy in chondrocyte response by in vitro experiments and experimental model of osteoarthritis in the knee.Mar 31, 2022

Electroacupuncture improves articular microcirculation and attenuates cartilage hypoxia in a male rabbit model of knee osteoarthritis.Jun 30, 2024

Emodin protects knee joint cartilage.Mar 14, 2021

Engeletin ameliorated osteoarthritis in vitro and in vivo.Dec 31, 2020

Epicatechin and scopoletin rich Morinda citrifolia leaf extract supplementation, mitigated OsteoarthritisFeb 28, 2019

Eugenol protects chondrocytes and articular cartilage.Jul 25, 2022

Ferulic acid may be a potential therapy for osteoarthritis.Jun 01, 2021

Ginsenoside Rb1 has potential for use as a therapeutic agent in osteoarthritis patients.Mar 31, 2012

Glabridin inhibits osteoarthritis development by protecting chondrocytes against oxidative stress, apoptosis.Feb 28, 2021

Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration.Dec 31, 2021

In vitro effects of cetylated fatty acids mixture from celadrin on chondrogenesis and inflammation with impact on osteoarthritis.Apr 30, 2018

Indirubin protects chondrocytes and alleviates osteoarthritis.Jan 31, 2023

Loganin ameliorates cartilage degeneration and osteoarthritis development.Jan 29, 2020

Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide.Aug 03, 2011

P-coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat model.Sep 09, 2017

PBM therapy was effective in recovering oxidative stress and preserving the articular cartilage aspects in a knee OA animal model.Mar 31, 2021

Phellinus linteus mycelium has a strong chondroprotective effect through the suppression both ROS production and inflammation.Dec 31, 2019

Piperlongumine mediates amelioration of osteoarthritis.Nov 07, 2023

Protective effects of Tripterygium glycoside on IL-1β-induced inflammation and apoptosis of rat chondrocytes.Sep 01, 2022

Puerarin may serve as a potential target in the treatment of osteoarthritis.Feb 04, 2019

Puerarin plays a protective role in chondrocytes by activating Beclin1-dependent autophagy.Feb 23, 2021

Quercetin exerts chondroprotective effects.Jul 06, 2024

Safranal can potentially prevent osteoarthritis development. Aug 09, 2022

Salvianolic acid A contributes to cartilage endplate cell restoration by regulating miR-940 and miR-576-5p.Oct 24, 2023

Salvianolic acid B activates chondrocytes autophagy and reduces chondrocyte apoptosis in obesity.Aug 02, 2022

Sodium Tanshinone IIA sulfonate ameliorates injury-induced oxidative stress and intervertebral disc degeneration.Dec 31, 2020

Tanshinone ⅡA ameliorates cartilage degeneration in ovariectomized rats.Jul 19, 2024

The present data highlights the chondroprotective effects of pomegranate fruit extract consumption.Dec 31, 2016

The protective effect of ginsenoside Rg1 on apoptosis in human ankle joint traumatic arthritis chondrocytes.Dec 31, 2021

Therapeutic effect of irradiation of magnetic infrared laser on osteoarthritis rat model.Dec 31, 2013

These findings suggest procyanidins can be used to mitigate osteoarthritis pathogenesis.Dec 08, 2016

These results show that the chondroprotective effects of wogonin are produced by its regulation of the gene expression.Aug 31, 2015

These results suggest that PBM associated with aerobic and aquatic exercise training were effective in mediating chondroprotective effects.Nov 30, 2018

This study demonstrated the anti-arthritic, anti-inflammatory, anti-oxidative stress and chondro-protective potentials of sesamol in vivo. Sep 30, 2013

Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation.Jul 04, 2020

Vitexin alleviates ER-stress-activated apoptosis and the related inflammation in chondrocytes.Nov 13, 2018

Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes.Dec 31, 2019

3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation.Dec 31, 2021

A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects.Mar 02, 2017

Activation of autophagy contributes to the protective effects of lycopene against oxidative stress-induced apoptosis in rat chondrocytes.Jun 30, 2021

Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair.Dec 31, 2017

Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes.Mar 31, 2024

Curcuma longa and Boswellia serrata extracts modulate different and complementary pathways on human chondrocytes.Dec 31, 2021

Curcumin exerts chondroprotective effects against osteoarthritis.May 09, 2022

Chondroprotective

View the Evidence:
114 Abstracts with Chondroprotective Research