Cyclin D1 Down-Regulation

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32 Substances Researched for Cyclin D1 Down-Regulation
NameACCKFocus
Garcinia indica27Locked
6-Shogaol15Locked
Gingerol 15Locked
Magnolol15Locked
Pterostilbene15Locked
Long Pepper24Locked
Pomegranate23Locked
Antrodia camphorata12Locked
Chaga Mushroom (Inonotus obliquus)12Locked
Cucurbitacin B 22Locked
Gac12Locked
Phellinus Linteus12Locked
Piperlongumine 12Locked
Reishi Mushroom12Locked
Resveratrol22Locked
Aloe Vera11Locked
Berbamine11Locked
Cucurbitacin E 11Locked
Curcumin11Locked
Cyanidin 3-glucoside11Locked
Genistein11Locked
Ginkgo biloba11Locked
Grape Seed Extract11Locked
Huaier (Trametes robiniophila murr)11Locked
Mistletoe11Locked
Molasses11Locked
Naringenin 11Locked
Nobiletin 11Locked
Prunella vulgaris.11Locked
Quercetin11Locked
Stilbenes11Locked
Wogonin11Locked

View the Evidence:
76 Abstracts with Cyclin D1 Down-Regulation Research

[+]

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Pubmed Data : J Agric Food Chem. 2015 Mar 11 ;63(9):2432-41. Epub 2015 Feb 25. PMID: 25686711
Article Published Date : Mar 10, 2015
Study Type : Human In Vitro
Additional Links
Substances : 6-Shogaol, Gingerol , Pterostilbene
Diseases : Breast Cancer, Breast Cancer Stem Cells
Pharmacological Actions : Chemosensitizer, Cyclin D1 Down-Regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Magnolol induced cell cycle arrest and promoted apoptosis in gallbladder carcinoma cells by regulating the p53 signaling pathway.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Sci. 2015 Oct ;106(10):1341-50. PMID: 26250568
Article Published Date : Sep 30, 2015
Study Type : Human In Vitro
Additional Links
Substances : Magnolol
Diseases : Gallbladder Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Xanthohumol targets the ERK1/2‑Fra1 signaling axis to reduce cyclin D1 expression and inhibit non‑small cell lung cancer.Jul 19, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2020 Jul 20. Epub 2020 Jul 20. PMID: 32945473
Article Published Date : Jul 19, 2020
Study Type : Animal Study
Additional Links
Substances : Xanthohumol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Chemotherapeutic, Cyclin D1 Down-Regulation, MicroRNA modulator
[+]

6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3β-cyclin D1 pathway in renal-cell carcinoma.Dec 11, 2019

Pubmed Data : Cancer Chemother Pharmacol. 2019 Dec 12. Epub 2019 Dec 12. PMID: 31832810
Article Published Date : Dec 11, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Kidney Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma.Nov 11, 2019

Pubmed Data : Environ Toxicol. 2019 Nov 12. Epub 2019 Nov 12. PMID: 31714653
Article Published Date : Nov 11, 2019
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Arctigenin attenuates tumor metastasis of hepatocellular carcinoma.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:937. Epub 2019 Aug 29. PMID: 31555129
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Cancer Metastasis, Liver Cancer
Pharmacological Actions : Anti-metastatic, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

CARI III exerted anti-cancer activity that is comparable to doxorubicin against melanoma in vivo, as well as in vitro.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2014 ;19(9):14383-95. Epub 2014 Sep 12. PMID: 25221864
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Antrodia camphorata, Chaga Mushroom (Inonotus obliquus), Phellinus Linteus, Reishi Mushroom
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
[+]

Co-treatment with piperlongumine led to a 1.68-fold enhancement in docetaxel bioavailability in SD rats.Sep 14, 2015

Pubmed Data : J Pharm Sci. 2015 Sep 15. Epub 2015 Sep 15. PMID: 26372815
Article Published Date : Sep 14, 2015
Study Type : Animal Study
Additional Links
Substances : Long Pepper, Piperlongumine
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Cyclin D1 Down-Regulation, Cytotoxic, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemotherapeutic Synergy: Docetaxel
[+]

Dietary administration of garcinol effectively reduced the tumor size and incidence in the mouse colon.Aug 31, 2014

Pubmed Data : Mol Nutr Food Res. 2014 Sep ;58(9):1820-9. Epub 2014 Jul 1. PMID: 24981158
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Substances : Garcinia indica
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor Inhibitors
[+]

Dietary phytochemicals have a beneficial effect on benign prostatic hyperplasia prevention.Nov 30, 2016

Pubmed Data : Appl Physiol Nutr Metab. 2016 Dec ;41(12):1303-1310. Epub 2016 Sep 27. PMID: 27849354
Article Published Date : Nov 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Prostatic Hyperplasia: Benign
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation
[+]

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine.Apr 14, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cancer Res. 2012 Apr 15 ;18(8):2220-9. Epub 2012 Feb 20. PMID: 22351692
Article Published Date : Apr 14, 2012
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Gamma, Vitamin E
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Bcl-2 protein down-regulation, Chemosensitizer, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Gac seed extract suppresses breast cancer growth by inducing cell cycle arrest and apoptosis.Aug 04, 2015

Pubmed Data : Mol Med Rep. 2015 Aug 5. Epub 2015 Aug 5. PMID: 26252798
Article Published Date : Aug 04, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gac
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Dose Response, Plant Extracts
[+]

Ganoderma extracts and spores oil possessed antitumor effects in vitro and in vivo.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Nov ;12(5):3571-3578. Epub 2016 Aug 29. PMID: 27900038
Article Published Date : Oct 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Cancers: All
Pharmacological Actions : Cell cycle arrest, Cyclin D1 Down-Regulation, Topoisomerase I inhibitor, Topoisomerase II Inhibitor
Additional Keywords : Dose Response
[+]

Ganoderma lucidum triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas.Dec 31, 2016

Pubmed Data : Mutat Res. 2017 Jan ;813:45-51. Epub 2016 Dec 2. PMID: 28010928
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom
Diseases : Breast Cancer, Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Chemopreventive, Cyclin D1 Down-Regulation
Additional Keywords : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer, Chemopreventive, Cyclin D1 Down-Regulation, Reishi Mushroom, skin cancer
[+]

Isoquercitrin protects against pulmonary hypertension Feb 28, 2017

Pubmed Data : Clin Exp Pharmacol Physiol. 2017 Mar ;44(3):362-370. PMID: 27873355
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Isoquercitrin
Diseases : Hypertension: Pulmonary
Pharmacological Actions : Antihypertensive Agents, Antioxidants, Antiproliferative , Cyclin D1 Down-Regulation
[+]

Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced solid ehrlich carcinomaAug 31, 2019

Pubmed Data : Chem Biol Interact. 2019 Sep 1 ;310:108740. Epub 2019 Jul 6. PMID: 31288002
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Piperlongumine is a promising antitumor agent that deserves further study for colorectal cancer treatment.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2020 ;13:5591-5603. Epub 2020 Jun 15. PMID: 32606774
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclin D1 Down-Regulation
[+]

Piperlongumine suppresses growth and sensitizes pancreatic tumors to gemcitabine in a xenograft mouse model.Dec 13, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 Dec 14. Epub 2015 Dec 14. PMID: 26667450
Article Published Date : Dec 13, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Long Pepper
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Chemosensitizer, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Survivin Down-Regulation, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Pomegranate hull extract has antitumorigenic effect and could be a candidate for anticancer drugs.Jul 05, 2016

Pubmed Data : Nutr Cancer. 2016 Jul 6:1-8. Epub 2016 Jul 6. PMID: 27383944
Article Published Date : Jul 05, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation
Additional Keywords : Plant Extracts
[+]

The combined effect of pomegranate extract and tangeretin on the DMBA-induced breast cancer model.Dec 12, 2020

Pubmed Data : J Nutr Biochem. 2020 Dec 13:108566. Epub 2020 Dec 13. PMID: 33326843
Article Published Date : Dec 12, 2020
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Tangeretin
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation
[+]

These results indicate the potential of curcumol in the prevention of colon cancer carcinogenesis.Jan 09, 2018

Pubmed Data : J Ethnopharmacol. 2018 Jan 10 ;210:1-9. Epub 2017 Jul 4. PMID: 28684297
Article Published Date : Jan 09, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation
[+]

Annurca apple polyphenol extract strongly inhibits the proliferation of MCF-7 cells by inducing G2/M cell cycle arrest and apoptosis.Aug 31, 2017

Pubmed Data : Int J Oncol. 2017 Sep ;51(3):939-948. Epub 2017 Jul 31. PMID: 28766690
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells.Sep 25, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Sep 26 ;16(1):373. Epub 2016 Sep 26. PMID: 27670681
Article Published Date : Sep 25, 2016
Study Type : In Vitro Study
Additional Links
Substances : Babchi
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Cyclin D1 Down-Regulation
[+]

Anticancer activity of calyx of Diospyros kaki Thunb. Sep 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Sep 5 ;17(1):445. Epub 2017 Sep 5. PMID: 28870200
Article Published Date : Sep 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Persimmon
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cyclin D1 Down-Regulation, Wnt/β-catenin pathway down-regulation
Additional Keywords : Plant Extracts
[+]

Berbamine may be a promising candidate to be used in combination with gemcitabine for pancreatic cancer treatment.Apr 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anat Rec (Hoboken). 2014 May ;297(5):802-9. Epub 2014 Mar 12. PMID: 24619961
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Berbamine
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells.Sep 30, 2006

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2006 Oct ;374(1):11-20. Epub 2006 Sep 9. PMID: 16964520
Article Published Date : Sep 30, 2006
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer, Colon Cancer, Glioma, Lung Cancer, Neuroblastoma, Rhabdomyosarcoma, Thyroid Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation
[+]

Cardamonin induces G2/M arrest and apoptosis via activation of the JNK-FOXO3a pathway in breast cancer cells.Aug 07, 2019

Pubmed Data : Cell Biol Int. 2019 Aug 8. Epub 2019 Aug 8. PMID: 31393045
Article Published Date : Aug 07, 2019
Study Type : In Vitro Study
Additional Links
Substances : Cardamonin
Diseases : Breast Cancer
Pharmacological Actions : Anti-Apoptotic, Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation
[+]

Combination of tanshinone IIA and cisplatin inhibits esophageal cancer.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2020 ;10:1756. Epub 2020 Sep 10. PMID: 33014864
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, P21 Activation, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Crocin has therapeutic and preventive effects on cancer cell lines.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Jan ;23(1):3-12. PMID: 32405344
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Breast Cancer, Colorectal Cancer, Leukemia: Chronic myelogenous leukemia (CML) , Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Telomerase Inhibitor
[+]

Cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis in human colorectal cancer cell lines.Jul 15, 2015

Pubmed Data : Hum Exp Toxicol. 2015 Jul 16. Epub 2015 Jul 16. PMID: 26183715
Article Published Date : Jul 15, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Chemotherapeutic Synergy: Gefitinib
[+]

Cucurbitacin B induced S phase arrest and apoptosis in BEL-7402 hepatocellular carcinoma cells.Jul 31, 2010

Pubmed Data : Cancer Lett. 2010 Aug 1 ;294(1):118-24. Epub 2010 Feb 11. PMID: 20153103
Article Published Date : Jul 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the oncogenic activation.Feb 28, 2019

Pubmed Data : Planta Med. 2019 Mar ;85(5):370-378. Epub 2018 Nov 21. PMID: 30463098
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Cyclin D1 Down-Regulation, Survivin Down-Regulation
[+]

Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(7):e103760. Epub 2014 Jul 29. PMID: 25072848
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin E
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, Survivin Down-Regulation
[+]

Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells.Dec 31, 2018

Pubmed Data : Phytomedicine. 2019 Jan ;52:117-128. Epub 2018 Sep 28. PMID: 30599890
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Quercetin
Diseases : Breast Cancer, Colorectal Cancer, Lung Cancer, Melanoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Natural Substance Synergy
[+]

Curcumin demonstrates promising therapeutic potential as a new treatment modality for head and neck cancer management.Oct 26, 2015

Pubmed Data : ACS Comb Sci. 2015 Oct 27. Epub 2015 Oct 27. PMID: 26505786
Article Published Date : Oct 26, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Head and Neck Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin
[+]

Cyanidin-3-O-glucoside chloride exhibits cytotoxicity on Caco-2 cells in vitro and induces apoptosis in Caco-2 cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(7). Epub 2016 Jun 23. PMID: 27347927
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cyanidin 3-glucoside, Molasses
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Cyclin D1 Down-Regulation, Cytotoxic
[+]

Daidzein may prove beneficial in the development of melanoma systemic therapy. Dec 31, 2019

Pubmed Data : J BUON. 2020 Jan-Feb;25(1):485-490. PMID: 32277673
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Damnacanthal has potential to be a candidate for the development of chemoprevention or therapeutic agents for cancers.Apr 30, 2016

Pubmed Data : Life Sci. 2016 May 1 ;152:60-6. Epub 2016 Mar 24. PMID: 27018445
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Damnacanthal
Diseases : Breast Cancer, Cancers: All, Colorectal Cancer, Prostate Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Chemotherapeutic, Cyclin D1 Down-Regulation
[+]

DIM downregulates cyclin D1 through triggering ER stress in human colorectal cancer cells.Jun 30, 2017

Pubmed Data : Oncol Rep. 2017 Jul ;38(1):569-574. Epub 2017 Jun 1. PMID: 28586058
Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Colorectal Cancer
Pharmacological Actions : Cyclin D1 Down-Regulation
[+]

Fisetin inhibits the growth and migration in the A549 human lung cancer cell line.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Mar ;15(3):2667-2673. Epub 2017 Dec 21. PMID: 29467859
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Ganoderma lucidum put forth anti-tumor activity against PC-3 prostate cancer cells.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2020 Oct ;27(10):2632-2637. Epub 2020 Jun 3. PMID: 32994721
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation, STAT3 Inhibitor
[+]

Genistein induced cell cycle G2/M arrest in human salivary adenoid cystic carcinoma cell line SACC-83.Jan 31, 2006

Pubmed Data : Shanghai Kou Qiang Yi Xue. 2006 Feb ;15(1):69-72. PMID: 16525614
Article Published Date : Jan 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Head and Neck Cancer, Salivary Gland Adenoid Cystic Carcinoma., Salivary Gland Diseases
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression.Apr 30, 2018

Pubmed Data : Mol Med Rep. 2018 May ;17(5):7265-7273. Epub 2018 Mar 16. PMID: 29568950
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Wnt/β-catenin signaling pathway modulation
[+]

Ginkgolide B from ginkgo biloba has an antiproliferative and apoptosis-Inducing effect on ovarian cancer cellsApr 13, 2012

Pubmed Data : Integr Cancer Ther. 2012 Apr 13. Epub 2012 Apr 13. PMID: 22505596
Article Published Date : Apr 13, 2012
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Chemosensitizer, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
Problem Substances : Cisplatin
[+]

Grape seed procyanidin extract inhibits cell proliferation by inducing cell cycle arrest and apoptosis in BIU87 cells.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2016 Jul ;20(15):3282-91. PMID: 27467005
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, Survivin Down-Regulation
Additional Keywords : Plant Extracts
[+]

Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells.Dec 31, 2012

Pubmed Data : Am J Chin Med. 2013 ;41(6):1439-57. PMID: 24228611
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus, Polyphenols
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Hispolon induces apoptosis against prostate DU145 cancer cells via modulation of mitochondrial and STAT3 pathways.Aug 31, 2019

Pubmed Data : Pak J Pharm Sci. 2019 Sep ;32(5(Supplementary)):2237-2243. PMID: 31894049
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus, Polyphenols
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation, STAT3 Inhibitor
[+]

Huaier extract causes HCC cell apoptosis and induces hepatocellular carcinoma cells arrest in S phase.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:171356. Epub 2015 Jun 28. PMID: 26229542
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Huaier (Trametes robiniophila murr)
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Dose Response, Plant Extracts
[+]

Inhibition of NF-kappaB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel.Apr 30, 2009

Pubmed Data : Arch Pharm Res. 2009 May ;32(5):755-65. Epub 2009 May 27. PMID: 19471891
Article Published Date : Apr 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Inhibitory effects of nobiletin and its major metabolites on lung tumorigenesis.Oct 29, 2019

Pubmed Data : Food Funct. 2019 Oct 30. Epub 2019 Oct 30. PMID: 31664275
Article Published Date : Oct 29, 2019
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation
[+]

Isoliquiritigenin could be a promising agent for preventing hepatocellular carcinoma tumorigenesis and metastasis.Jan 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2020 01 31 ;40(1). PMID: 31840737
Article Published Date : Jan 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclin D1 Down-Regulation
[+]

Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function.Dec 14, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2016 Dec 15 ;313:204-214. Epub 2016 Oct 3. PMID: 27702603
Article Published Date : Dec 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Pituitary Tumours
Pharmacological Actions : Antiproliferative , Chemopreventive, Cyclin D1 Down-Regulation
[+]

Kahweol-mediated cyclin D1 degradation may contribute to the inhibition of the proliferation in human colorectal cancer cells.Aug 31, 2016

Pubmed Data : Food Chem Toxicol. 2016 Sep ;95:142-8. Epub 2016 Jul 14. PMID: 27424123
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Kahweol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation
[+]

Lycopene and β-carotene may act as potent anti-proliferative agents in ESCC cells.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 May ;15(5):6727-6732. Epub 2018 Mar 5. PMID: 29731858
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : beta-Carotene, Lycopene
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, P21 Activation
[+]

Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

Pubmed Data : Food Chem Toxicol. 2017 Feb ;100:149-160. Epub 2016 Dec 23. PMID: 28025124
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Ursolic Acid
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Antiproliferative, Breast Cancer: Triple Negative, Dose Response, Hawthorn, Ursolic Acid
[+]

Naringenin inhibited the cell proliferation in HCT116 and SW480 cells and decreased the level of cyclin D1 protein.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 Jul ;23(4):339-44. Epub 2015 Jul 1. PMID: 26157550
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Naringenin
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation
[+]

Nobiletin may have potential for treating glioblastoma multiforme.Nov 11, 2015

Pubmed Data : Phytother Res. 2015 Nov 12. Epub 2015 Nov 12. PMID: 26560814
Article Published Date : Nov 11, 2015
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Quercetin reduces cyclin D1 activity and induces G1 phase arrest in HepG2 cells.Jun 30, 2016

Pubmed Data : Oncol Lett. 2016 Jul ;12(1):516-522. Epub 2016 May 27. PMID: 27347174
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Quercetin suppresses breast cancer stem cells.Jan 15, 2018

Pubmed Data : Life Sci. 2018 Jan 16. Epub 2018 Jan 16. PMID: 29355544
Article Published Date : Jan 15, 2018
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Cancer Stem Cells
[+]

Resveratrol induces programmed cell death and cell cycle arrest of human bladder cancer cells.Feb 01, 2010

Pubmed Data : Cancer Sci. 2010 Feb;101(2):488-93. Epub 2009 Oct 27. PMID: 20028382
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Bladder Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, Cyclin-Dependent Kinase 4 Down-Regulation, P21 Activation, Phosphorylated Rb Down-Regulation
[+]

Rheum palmatum extract exerts anti-hepatocellular carcinoma effects by inhibiting signal transducer and activator of transcription 3 signaling.Mar 24, 2019

Pubmed Data : J Ethnopharmacol. 2019 Mar 25 ;232:62-72. Epub 2018 Dec 13. PMID: 30553869
Article Published Date : Mar 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Rhubarb
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cyclin D1 Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor, Survivin Down-Regulation
Additional Keywords : Plant Extracts
[+]

Sanguinarine as a potent inhibitor of dihydrofolate reductase, able to impair enzyme activity even in methotrexate resistant MDA-MB-231 cells.Jul 31, 2014

Pubmed Data : Biochem Pharmacol. 2014 Aug 1 ;90(3):226-34. Epub 2014 May 27. PMID: 24875448
Article Published Date : Jul 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bloodroot
Diseases : Breast Cancer, Breast Cancer: Drug Resistant, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 Down-Regulation, Enzyme Inhibitors
Additional Keywords : Bloodroot, Breast Cancer, Breast Cancer: Drug Resistant, Breast Cancer: Triple Negative, Dose Response
[+]

Sasa veitchii extract induces anticancer effects via inhibition of cyclin D1 expression in MCF-7 cells.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nagoya J Med Sci. 2020 Aug ;82(3):509-518. PMID: 33132435
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bamboo
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Cyclin D1 Down-Regulation
[+]

Several pomegranate phytochemicals exhibited synergistic effects in suppressing growth of tumor cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015;20(12):22315-22328. Epub 2015 Dec 12. PMID: 26703530
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 Down-Regulation, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Natural Substance Synergy
[+]

Spica Prunellae inhibits the proliferation of colon cancer cells through G1/S cell cycle arrestSep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2013 Oct ;6(4):1123-1127. Epub 2013 Aug 5. PMID: 24137475
Article Published Date : Sep 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Prunella vulgaris
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Dose Response, Plant Extracts
[+]

Synergistic growth inhibitory effects of chrysin and metformin combination on breast cancer cells.Apr 24, 2018

Pubmed Data : Asian Pac J Cancer Prev. 2018 Apr 25 ;19(4):977-982. Epub 2018 Apr 25. PMID: 29693804
Article Published Date : Apr 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Chrysin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Tetrahydrocurcumin can synergistically enhance the radiosensitivity of glioma cells.May 31, 2018

Pubmed Data : J Pharm Pharmacol. 2018 Jun ;70(6):749-759. Epub 2018 Mar 1. PMID: 29492979
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Tetrahydrocurcumin
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, Radiosensitizer
[+]

These findings highlight the potential use of resveratrol as an adjuvant therapy for breast cancer.May 31, 2016

Pubmed Data : Oncol Rep. 2016 Jun ;35(6):3696-704. Epub 2016 Apr 4. PMID: 27109433
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Gene Expression Regulation
[+]

These findings indicate that fisetin is a promising antitumor agent against renal cell carcinoma.Aug 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2019 Aug 21 ;8(9). Epub 2019 Aug 21. PMID: 31438640
Article Published Date : Aug 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Kidney Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, P21 Activation
[+]

These results shed light on berberine's potential as an anti-tumor agent for clinical cancer therapy.Nov 14, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Nov 15 ;17(11). Epub 2016 Aug 15. PMID: 27854312
Article Published Date : Nov 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Liver Cancer
Pharmacological Actions : Cyclin D1 Down-Regulation
Additional Keywords : Dose Response
[+]

These results signify that Aloe vera may be an effective anti-neoplastic agent to inhibit cancer cell growth and increase the therapeutic efficacy of conventional drugs like cisplatin.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(7):2939-46. PMID: 25854386
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera
Diseases : Breast Cancer, Cervical Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Chemopreventive, Chemotherapeutic, Cyclin D1 Down-Regulation
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Ursolic acid can effectively inhibit the proliferation of osteosarcoma cell line U2-OS.Oct 31, 2017

Pubmed Data : Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Nov 1 ;31(11):1371-1376. PMID: 29798594
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Viscum album var showed evidence of anti-cancer activity through G1 phase cell cycle arrest in SK-Hep1 cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(15):6417-21. PMID: 26434853
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Mistletoe
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Plant Extracts
[+]

Vitamin C affects G0/G1 cell cycle and autophagy by downregulating of cyclin D1 in gastric carcinoma cells.Feb 23, 2021

Pubmed Data : Biosci Biotechnol Biochem. 2021 Feb 24 ;85(3):553-561. PMID: 33624781
Article Published Date : Feb 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Wogonin inhibits cell cycle progression by activating the glycogen synthase kinase-3 beta in hepatocellular carcinoma.Jan 17, 2020

Pubmed Data : Phytomedicine. 2020 Jan 18 ;68:153174. Epub 2020 Jan 18. PMID: 31991293
Article Published Date : Jan 17, 2020
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Wogonin inhibits the proliferation of myelodysplastic syndrome cells.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Nov ;12(5):7285-92. Epub 2015 Sep 23. PMID: 26398525
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Myelodysplastic Syndrome
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation

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