Cyclin D1 Down-Regulation

Name	AC	CK
Garcinia indica	2	7
Gingerol	2	7
Magnolol	2	7
Reishi Mushroom	4	7
Melatonin	3	6
6-Shogaol	1	5
Pomegranate	3	5
Pterostilbene	1	5
Cucurbitacin B	4	4
Lignans	2	4
Long Pepper	2	4
Phellinus Linteus	3	4
Curcumin	3	3
Ferulic acid	1	3
Naringenin	2	3
Quercetin	3	3
Andrographolide	1	2
Antrodia camphorata	1	2
Arctigenin	1	2
Baicalein	1	2
Berberine	2	2
Betulinic acid	2	2
Chaga Mushroom (Inonotus obliquus)	1	2
Curcumol	1	2
Daidzein	2	2
Fisetin	2	2
Flaxseed	1	2
Gac	1	2
Genistein	2	2
Isoliquiritigenin	2	2
Isoquercitrin	1	2
Luteolin	1	2
Nobiletin	2	2
Piperlongumine	1	2
Polyphenols	2	2
Resveratrol	2	2
Sinomenine	1	2
Tangeretin	1	2
Tocotrienol: Gamma	1	2
Ursolic Acid	2	2
Vitamin E	1	2
Walnut	1	2
Wogonin	2	2
Xanthohumol	1	2
Aloe Vera	1	1
Anthocyanins	1	1
Apple Polyphenols	1	1
Babchi	1	1
Bamboo	1	1
Beet	1	1
Berbamine	1	1
Bisdemethoxycurcumin	1	1
Bitter Melon	1	1
Bloodroot	1	1
Cardamonin	1	1
Chicory	1	1
Chrysin	1	1
Cordyceps Militaris	1	1
Crocetin	1	1
Crocin	1	1
Cucurbitacin E	1	1
Cyanidin 3-glucoside	1	1
Damnacanthal	1	1
Diosgenin	1	1
Fenugreek	1	1
Formononetin	1	1
Ginkgo biloba	1	1
Ginsenosides	1	1
Grape	1	1
Grape Seed Extract	1	1
Hawthorn	1	1
Horse Chestnut	1	1
Huaier (Trametes robiniophila murr)	1	1
Kahweol	1	1
Lycopene	1	1
Mangosteen	1	1
Mistletoe	1	1
Molasses	1	1
Neem	1	1
Oleuropein	1	1
Persimmon	1	1
Phlorotannins	1	1
Prunella vulgaris	1	1
Rhubarb	1	1
Saikosaponin	1	1
Stilbenes	1	1
Tanshinone IIA	1	1
Tetrahydrocurcumin	1	1
Vitamin C	1	1
beta-Carotene	1	1

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6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

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Pubmed Data : J Agric Food Chem. 2015 Mar 11 ;63(9):2432-41. Epub 2015 Feb 25. PMID: 25686711

Article Published Date : Mar 10, 2015

Study Type : Human In Vitro

Additional Links

Substances : 6-Shogaol, Gingerol , Pterostilbene

Diseases : Breast Cancer, Breast Cancer Stem Cells

Pharmacological Actions : Chemosensitizer, Cyclin D1 Down-Regulation

Additional Keywords : Natural Substance/Drug Synergy

[+]

Magnolol induced cell cycle arrest and promoted apoptosis in gallbladder carcinoma cells by regulating the p53 signaling pathway.Sep 30, 2015

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[+]

Co-treatment with piperlongumine led to a 1.68-fold enhancement in docetaxel bioavailability in SD rats.Sep 14, 2015

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Pubmed Data : J Pharm Sci. 2015 Sep 15. Epub 2015 Sep 15. PMID: 26372815

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Mutat Res. 2017 Jan ;813:45-51. Epub 2016 Dec 2. PMID: 28010928

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Pubmed Data : Chem Biol Interact. 2019 Sep 1 ;310:108740. Epub 2019 Jul 6. PMID: 31288002

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Pubmed Data : Int J Oncol. 2017 Sep ;51(3):939-948. Epub 2017 Jul 31. PMID: 28766690

Article Published Date : Aug 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Apple Polyphenols

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation

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Anthocyanins isolated from fruits of Vitis coignetiae Pulliat inhibit cancer proliferation, cancer migration, and invasion.Jan 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Oncol. 2020 ;10:1756. Epub 2020 Sep 10. PMID: 33014864

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Pubmed Data : Hum Exp Toxicol. 2015 Jul 16. Epub 2015 Jul 16. PMID: 26183715

Article Published Date : Jul 15, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation

Additional Keywords : Chemotherapeutic Synergy: Gefitinib

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Cucurbitacin B induced S phase arrest and apoptosis in BEL-7402 hepatocellular carcinoma cells.Jul 31, 2010

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Pubmed Data : Cancer Lett. 2010 Aug 1 ;294(1):118-24. Epub 2010 Feb 11. PMID: 20153103

Article Published Date : Jul 31, 2010

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Integr Cancer Ther. 2012 Apr 13. Epub 2012 Apr 13. PMID: 22505596

Article Published Date : Apr 13, 2012

Study Type : In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Chemosensitizer, Cyclin D1 Down-Regulation, P21 Activation

Additional Keywords : Natural Substances Versus Drugs, Plant Extracts

Problem Substances : Cisplatin

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Grape seed procyanidin extract inhibits cell proliferation by inducing cell cycle arrest and apoptosis in BIU87 cells.Jun 30, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2016 Jul ;20(15):3282-91. PMID: 27467005

Article Published Date : Jun 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Grape Seed Extract

Diseases : Bladder Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, Survivin Down-Regulation

Additional Keywords : Plant Extracts

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Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

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Pubmed Data : Food Chem Toxicol. 2017 Feb ;100:149-160. Epub 2016 Dec 23. PMID: 28025124

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cells. 2019 Aug 21 ;8(9). Epub 2019 Aug 21. PMID: 31438640

Article Published Date : Aug 20, 2019

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Kidney Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, P21 Activation

[+]

These results shed light on berberine's potential as an anti-tumor agent for clinical cancer therapy.Nov 14, 2016

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Pubmed Data : Phytomedicine. 2020 Jan 18 ;68:153174. Epub 2020 Jan 18. PMID: 31991293

Article Published Date : Jan 17, 2020

Study Type : In Vitro Study

Additional Links

Substances : Wogonin

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation

[+]

Wogonin inhibits the proliferation of myelodysplastic syndrome cells.Oct 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2015 Nov ;12(5):7285-92. Epub 2015 Sep 23. PMID: 26398525

Article Published Date : Oct 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Wogonin

Diseases : Myelodysplastic Syndrome

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation

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View the Evidence: 103 Abstracts with Cyclin D1 Down-Regulation Research

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6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Magnolol induced cell cycle arrest and promoted apoptosis in gallbladder carcinoma cells by regulating the p53 signaling pathway.Sep 30, 2015

Ferulic acid nanocapsules as a promising treatment modality for colorectal cancer.May 31, 2022

Xanthohumol targets the ERK1/2‑Fra1 signaling axis to reduce cyclin D1 expression and inhibit non‑small cell lung cancer.Jul 19, 2020

6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3β-cyclin D1 pathway in renal-cell carcinoma.Dec 11, 2019

Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma.Nov 11, 2019

Arctigenin attenuates tumor metastasis of hepatocellular carcinoma.Dec 31, 2018

Arctiin inhibits inflammation, fibrosis, and tumor cell migration in rats with Ehrlich solid carcinoma.Aug 31, 2023

Baicalein inhibits cell proliferation and enhances apoptosis in human A549 cells and benzo(a)pyrene-induced pulmonary carcinogenesis in mice.Mar 24, 2022

CARI III exerted anti-cancer activity that is comparable to doxorubicin against melanoma in vivo, as well as in vitro.Dec 31, 2013

Co-treatment with piperlongumine led to a 1.68-fold enhancement in docetaxel bioavailability in SD rats.Sep 14, 2015

Dietary administration of garcinol effectively reduced the tumor size and incidence in the mouse colon.Aug 31, 2014

Dietary phytochemicals have a beneficial effect on benign prostatic hyperplasia prevention.Nov 30, 2016

Effects of sinomenine on a rat orthotopic liver carcinoma model.May 31, 2024

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine.Apr 14, 2012

Gac seed extract suppresses breast cancer growth by inducing cell cycle arrest and apoptosis.Aug 04, 2015

Ganoderma extracts and spores oil possessed antitumor effects in vitro and in vivo.Oct 31, 2016

Ganoderma lucidum triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas.Dec 31, 2016

Isoquercitrin protects against pulmonary hypertension Feb 28, 2017

Juglone may improve diabetic atherosclerosis by inhibiting proliferation and migration of VSMCs.Dec 31, 2019

Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced solid ehrlich carcinomaAug 31, 2019

Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta-catenin signaling.May 25, 2022

Melatonin inhibits AGS cell proliferation by binding to the ATP binding site of CDK2 under hyperglycemic conditions.Mar 06, 2024

Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota.Aug 18, 2022

Piperlongumine is a promising antitumor agent that deserves further study for colorectal cancer treatment.Dec 31, 2019

Piperlongumine suppresses growth and sensitizes pancreatic tumors to gemcitabine in a xenograft mouse model.Dec 13, 2015

Pomegranate hull extract has antitumorigenic effect and could be a candidate for anticancer drugs.Jul 05, 2016

The combined effect of pomegranate extract and tangeretin on the DMBA-induced breast cancer model.Dec 12, 2020

These results indicate the potential of curcumol in the prevention of colon cancer carcinogenesis.Jan 09, 2018

Administration. momordicine treatment reduced HNC xenograft tumor growth.Mar 20, 2021

Annurca apple polyphenol extract strongly inhibits the proliferation of MCF-7 cells by inducing G2/M cell cycle arrest and apoptosis.Aug 31, 2017

Anthocyanins isolated from fruits of Vitis coignetiae Pulliat inhibit cancer proliferation, cancer migration, and invasion.Jan 25, 2017

Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells.Sep 25, 2016

Anticancer activity of calyx of Diospyros kaki Thunb. Sep 04, 2017

Anticancer effects of root and beet leaf extracts (Beta vulgaris L.) in cervical cancer cells (HeLa).Sep 07, 2021

Berbamine may be a promising candidate to be used in combination with gemcitabine for pancreatic cancer treatment.Apr 30, 2014

Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells.Sep 30, 2006

Betulinic acid regulates the proliferation of SGC-7901 cells.Oct 31, 2020

Bisdemethoxycurcumin inhibits VEGF-induced HUVECs proliferation, migration and invasion.Jun 20, 2022

Cardamonin induces G2/M arrest and apoptosis via activation of the JNK-FOXO3a pathway in breast cancer cells.Aug 07, 2019

Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.Aug 18, 2022

Combination of tanshinone IIA and cisplatin inhibits esophageal cancer.Dec 31, 2019

Cordycepin suppresses the malignant phenotypes of colon cancer through the GSK3β/β-catenin/cyclin D1 signaling pathway.Apr 30, 2022

Crocetin imparts antiproliferative activity in hepatocellular carcinoma.Sep 11, 2021

Crocin has therapeutic and preventive effects on cancer cell lines.Dec 31, 2019

Cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis in human colorectal cancer cell lines.Jul 15, 2015

Cucurbitacin B induced S phase arrest and apoptosis in BEL-7402 hepatocellular carcinoma cells.Jul 31, 2010

Cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the oncogenic activation.Feb 28, 2019

Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.Dec 31, 2013

Cucurbitacin-B could serve in the prevention of prostate cancer. Oct 05, 2022

Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells.Dec 31, 2018

Curcumin demonstrates promising therapeutic potential as a new treatment modality for head and neck cancer management.Oct 26, 2015

Cyanidin-3-O-glucoside chloride exhibits cytotoxicity on Caco-2 cells in vitro and induces apoptosis in Caco-2 cells.Dec 31, 2015

Daidzein and chicory extract arrest the cell cycle via inhibition of cyclin D/CDK4 and cyclin A/CDK2 gene expression in hepatocellular carcinoma.Mar 20, 2022

Daidzein may prove beneficial in the development of melanoma systemic therapy. Dec 31, 2019

Damnacanthal has potential to be a candidate for the development of chemoprevention or therapeutic agents for cancers.Apr 30, 2016

DIM downregulates cyclin D1 through triggering ER stress in human colorectal cancer cells.Jun 30, 2017

Diosgenin inhibits Wnt/β-catenin pathway to regulate the proliferation and differentiation of MG-63 cells.Mar 31, 2021

Eckol inhibits Reg3A-induced proliferation of human SW1990 pancreatic cancer cells.Sep 30, 2019

Escin sensitized pancreatic cancer cells to chemotherapy.Dec 31, 2012

Fenugreek seed extract merits further investigation as a source of compounds with anti-cancer properties.Jun 30, 2023

Fisetin inhibits the growth and migration in the A549 human lung cancer cell line.Feb 28, 2018

Formononetin inhibits the pathogenesis and progression of esophageal cancer.Feb 28, 2023

Ganoderma lucidum put forth anti-tumor activity against PC-3 prostate cancer cells.Sep 30, 2020

Genistein induced cell cycle G2/M arrest in human salivary adenoid cystic carcinoma cell line SACC-83.Jan 31, 2006

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression.Apr 30, 2018

Ginkgolide B from ginkgo biloba has an antiproliferative and apoptosis-Inducing effect on ovarian cancer cellsApr 13, 2012

Grape seed procyanidin extract inhibits cell proliferation by inducing cell cycle arrest and apoptosis in BIU87 cells.Jun 30, 2016

Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells.Dec 31, 2012

Hispolon induces apoptosis against prostate DU145 cancer cells via modulation of mitochondrial and STAT3 pathways.Aug 31, 2019

Huaier extract causes HCC cell apoptosis and induces hepatocellular carcinoma cells arrest in S phase.Dec 31, 2014

Inhibition of NF-kappaB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel.Apr 30, 2009

Cyclin D1 Down-Regulation

View the Evidence:
103 Abstracts with Cyclin D1 Down-Regulation Research