Cyclin D1 Down-Regulation

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70 Substances Researched for Cyclin D1 Down-Regulation
NameACCKFocus
Garcinia indica27Locked
Gingerol 27Locked
Magnolol27Locked
Reishi Mushroom47Locked
6-Shogaol15Locked
Pomegranate35Locked
Pterostilbene15Locked
Long Pepper24Locked
Phellinus Linteus34Locked
Cucurbitacin B 33Locked
Curcumin33Locked
Quercetin33Locked
Antrodia camphorata12Locked
Arctigenin12Locked
Betulinic acid22Locked
Chaga Mushroom (Inonotus obliquus)12Locked
Curcumol12Locked
Fisetin22Locked
Flaxseed12Locked
Gac12Locked
Genistein22Locked
Isoliquiritigenin22Locked
Isoquercitrin12Locked
Lignans12Locked
Luteolin12Locked
Nobiletin 22Locked
Piperlongumine 12Locked
Polyphenols22Locked
Resveratrol22Locked
Tangeretin 12Locked
Tocotrienol: Gamma12Locked
Ursolic Acid22Locked
Vitamin E12Locked
Wogonin22Locked
Xanthohumol12Locked
Aloe Vera11Locked
Anthocyanins11Locked
Apple Polyphenols11Locked
Babchi11Locked
Bamboo11Locked
Berbamine11Locked
Berberine11Locked
Bloodroot11Locked
Cardamonin11Locked
Chrysin11Locked
Crocin11Locked
Cucurbitacin E 11Locked
Cyanidin 3-glucoside11Locked
Daidzein11Locked
Damnacanthal11Locked
Ginkgo biloba11Locked
Ginsenosides11Locked
Grape11Locked
Grape Seed Extract11Locked
Hawthorn11Locked
Huaier (Trametes robiniophila murr)11Locked
Kahweol11Locked
Lycopene11Locked
Mistletoe11Locked
Molasses11Locked
Naringenin 11Locked
Persimmon 11Locked
Phlorotannins11Locked
Prunella vulgaris11Locked
Rhubarb11Locked
Stilbenes11Locked
Tanshinone IIA11Locked
Tetrahydrocurcumin11Locked
Vitamin C11Locked
beta-Carotene11Locked

View the Evidence:
85 Abstracts with Cyclin D1 Down-Regulation Research

[+]

6-shogaol, 6-gingerol and pterostilbene selectively killed breast cancer stem cells.Mar 10, 2015

Pubmed Data : J Agric Food Chem. 2015 Mar 11 ;63(9):2432-41. Epub 2015 Feb 25. PMID: 25686711
Article Published Date : Mar 10, 2015
Study Type : Human In Vitro
Additional Links
Substances : 6-Shogaol, Gingerol , Pterostilbene
Diseases : Breast Cancer, Breast Cancer Stem Cells
Pharmacological Actions : Chemosensitizer, Cyclin D1 Down-Regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Magnolol induced cell cycle arrest and promoted apoptosis in gallbladder carcinoma cells by regulating the p53 signaling pathway.Sep 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Sci. 2015 Oct ;106(10):1341-50. PMID: 26250568
Article Published Date : Sep 30, 2015
Study Type : Human In Vitro
Additional Links
Substances : Magnolol
Diseases : Gallbladder Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Xanthohumol targets the ERK1/2‑Fra1 signaling axis to reduce cyclin D1 expression and inhibit non‑small cell lung cancer.Jul 19, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Rep. 2020 Jul 20. Epub 2020 Jul 20. PMID: 32945473
Article Published Date : Jul 19, 2020
Study Type : Animal Study
Additional Links
Substances : Xanthohumol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Chemotherapeutic, Cyclin D1 Down-Regulation, MicroRNA modulator
[+]

6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3β-cyclin D1 pathway in renal-cell carcinoma.Dec 11, 2019

Pubmed Data : Cancer Chemother Pharmacol. 2019 Dec 12. Epub 2019 Dec 12. PMID: 31832810
Article Published Date : Dec 11, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Kidney Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma.Nov 11, 2019

Pubmed Data : Environ Toxicol. 2019 Nov 12. Epub 2019 Nov 12. PMID: 31714653
Article Published Date : Nov 11, 2019
Study Type : Animal Study
Additional Links
Substances : Magnolol
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Apoptotic, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors
[+]

Arctigenin attenuates tumor metastasis of hepatocellular carcinoma.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:937. Epub 2019 Aug 29. PMID: 31555129
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Cancer Metastasis, Liver Cancer
Pharmacological Actions : Anti-metastatic, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, Wnt/β-catenin signaling pathway modulation
[+]

CARI III exerted anti-cancer activity that is comparable to doxorubicin against melanoma in vivo, as well as in vitro.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2014 ;19(9):14383-95. Epub 2014 Sep 12. PMID: 25221864
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Antrodia camphorata, Chaga Mushroom (Inonotus obliquus), Phellinus Linteus, Reishi Mushroom
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Plant Extracts, Superiority of Natural Substances versus Drugs
[+]

Co-treatment with piperlongumine led to a 1.68-fold enhancement in docetaxel bioavailability in SD rats.Sep 14, 2015

Pubmed Data : J Pharm Sci. 2015 Sep 15. Epub 2015 Sep 15. PMID: 26372815
Article Published Date : Sep 14, 2015
Study Type : Animal Study
Additional Links
Substances : Long Pepper, Piperlongumine
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Cyclin D1 Down-Regulation, Cytotoxic, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemotherapeutic Synergy: Docetaxel
[+]

Dietary administration of garcinol effectively reduced the tumor size and incidence in the mouse colon.Aug 31, 2014

Pubmed Data : Mol Nutr Food Res. 2014 Sep ;58(9):1820-9. Epub 2014 Jul 1. PMID: 24981158
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Substances : Garcinia indica
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Chemopreventive, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor Inhibitors
[+]

Dietary phytochemicals have a beneficial effect on benign prostatic hyperplasia prevention.Nov 30, 2016

Pubmed Data : Appl Physiol Nutr Metab. 2016 Dec ;41(12):1303-1310. Epub 2016 Sep 27. PMID: 27849354
Article Published Date : Nov 30, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flaxseed, Lignans
Diseases : Prostatic Hyperplasia: Benign
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation
[+]

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine.Apr 14, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cancer Res. 2012 Apr 15 ;18(8):2220-9. Epub 2012 Feb 20. PMID: 22351692
Article Published Date : Apr 14, 2012
Study Type : Animal Study
Additional Links
Substances : Tocotrienol: Gamma, Vitamin E
Diseases : Gastric Cancer
Pharmacological Actions : Anti-metastatic, Bcl-2 protein down-regulation, Chemosensitizer, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Gac seed extract suppresses breast cancer growth by inducing cell cycle arrest and apoptosis.Aug 04, 2015

Pubmed Data : Mol Med Rep. 2015 Aug 5. Epub 2015 Aug 5. PMID: 26252798
Article Published Date : Aug 04, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gac
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Dose Response, Plant Extracts
[+]

Ganoderma extracts and spores oil possessed antitumor effects in vitro and in vivo.Oct 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2016 Nov ;12(5):3571-3578. Epub 2016 Aug 29. PMID: 27900038
Article Published Date : Oct 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Cancers: All
Pharmacological Actions : Cell cycle arrest, Cyclin D1 Down-Regulation, Topoisomerase I inhibitor, Topoisomerase II Inhibitor
Additional Keywords : Dose Response
[+]

Ganoderma lucidum triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas.Dec 31, 2016

Pubmed Data : Mutat Res. 2017 Jan ;813:45-51. Epub 2016 Dec 2. PMID: 28010928
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom
Diseases : Breast Cancer, Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Chemopreventive, Cyclin D1 Down-Regulation
Additional Keywords : Anticarcinogenic Agents, Apoptotic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Breast Cancer, Chemopreventive, Cyclin D1 Down-Regulation, Reishi Mushroom, skin cancer
[+]

Isoquercitrin protects against pulmonary hypertension Feb 28, 2017

Pubmed Data : Clin Exp Pharmacol Physiol. 2017 Mar ;44(3):362-370. PMID: 27873355
Article Published Date : Feb 28, 2017
Study Type : Animal Study
Additional Links
Substances : Isoquercitrin
Diseases : Hypertension: Pulmonary
Pharmacological Actions : Antihypertensive Agents, Antioxidants, Antiproliferative , Cyclin D1 Down-Regulation
[+]

Juglone may improve diabetic atherosclerosis by inhibiting proliferation and migration of VSMCs.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:4196482. Epub 2020 Jul 23. PMID: 32774672
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Walnut
Diseases : Atherosclerosis, Diabetic Complications
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced solid ehrlich carcinomaAug 31, 2019

Pubmed Data : Chem Biol Interact. 2019 Sep 1 ;310:108740. Epub 2019 Jul 6. PMID: 31288002
Article Published Date : Aug 31, 2019
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Piperlongumine is a promising antitumor agent that deserves further study for colorectal cancer treatment.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Onco Targets Ther. 2020 ;13:5591-5603. Epub 2020 Jun 15. PMID: 32606774
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Colorectal Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclin D1 Down-Regulation
[+]

Piperlongumine suppresses growth and sensitizes pancreatic tumors to gemcitabine in a xenograft mouse model.Dec 13, 2015

Pubmed Data : Cancer Prev Res (Phila). 2015 Dec 14. Epub 2015 Dec 14. PMID: 26667450
Article Published Date : Dec 13, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Long Pepper
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Chemosensitizer, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Survivin Down-Regulation, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Pomegranate hull extract has antitumorigenic effect and could be a candidate for anticancer drugs.Jul 05, 2016

Pubmed Data : Nutr Cancer. 2016 Jul 6:1-8. Epub 2016 Jul 6. PMID: 27383944
Article Published Date : Jul 05, 2016
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation
Additional Keywords : Plant Extracts
[+]

The combined effect of pomegranate extract and tangeretin on the DMBA-induced breast cancer model.Dec 12, 2020

Pubmed Data : J Nutr Biochem. 2020 Dec 13:108566. Epub 2020 Dec 13. PMID: 33326843
Article Published Date : Dec 12, 2020
Study Type : Animal Study
Additional Links
Substances : Pomegranate, Tangeretin
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation
[+]

These results indicate the potential of curcumol in the prevention of colon cancer carcinogenesis.Jan 09, 2018

Pubmed Data : J Ethnopharmacol. 2018 Jan 10 ;210:1-9. Epub 2017 Jul 4. PMID: 28684297
Article Published Date : Jan 09, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation
[+]

Administration. momordicine treatment reduced HNC xenograft tumor growth.Mar 20, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2021 Mar 21 ;13(6). Epub 2021 Mar 21. PMID: 33801016
Article Published Date : Mar 20, 2021
Study Type : In Vitro Study
Additional Links
Substances : Bitter Melon
Diseases : Head and Neck Cancer
Pharmacological Actions : Chemotherapeutic, Cyclin D1 Down-Regulation, STAT3 Inhibitor
[+]

Annurca apple polyphenol extract strongly inhibits the proliferation of MCF-7 cells by inducing G2/M cell cycle arrest and apoptosis.Aug 31, 2017

Pubmed Data : Int J Oncol. 2017 Sep ;51(3):939-948. Epub 2017 Jul 31. PMID: 28766690
Article Published Date : Aug 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Apple Polyphenols
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Anthocyanins isolated from fruits of Vitis coignetiae Pulliat inhibit cancer proliferation, cancer migration, and invasion.Jan 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2017 11 26 ;18(11):2919-2923. Epub 2017 Nov 26. PMID: 29172259
Article Published Date : Jan 25, 2017
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins, Grape
Diseases : Lung Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells.Sep 25, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 Sep 26 ;16(1):373. Epub 2016 Sep 26. PMID: 27670681
Article Published Date : Sep 25, 2016
Study Type : In Vitro Study
Additional Links
Substances : Babchi
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Cyclin D1 Down-Regulation
[+]

Anticancer activity of calyx of Diospyros kaki Thunb. Sep 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Sep 5 ;17(1):445. Epub 2017 Sep 5. PMID: 28870200
Article Published Date : Sep 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Persimmon
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cyclin D1 Down-Regulation, Wnt/β-catenin pathway down-regulation
Additional Keywords : Plant Extracts
[+]

Anticancer effects of root and beet leaf extracts (Beta vulgaris L.) in cervical cancer cells (HeLa).Sep 07, 2021

Pubmed Data : Phytother Res. 2021 Sep 8. Epub 2021 Sep 8. PMID: 34494317
Article Published Date : Sep 07, 2021
Study Type : In Vitro Study
Additional Links
Substances : Beet
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation
[+]

Berbamine may be a promising candidate to be used in combination with gemcitabine for pancreatic cancer treatment.Apr 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Anat Rec (Hoboken). 2014 May ;297(5):802-9. Epub 2014 Mar 12. PMID: 24619961
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Berbamine
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine
[+]

Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells.Sep 30, 2006

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2006 Oct ;374(1):11-20. Epub 2006 Sep 9. PMID: 16964520
Article Published Date : Sep 30, 2006
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Breast Cancer, Colon Cancer, Glioma, Lung Cancer, Neuroblastoma, Rhabdomyosarcoma, Thyroid Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation
[+]

Betulinic acid regulates the proliferation of SGC-7901 cells.Oct 31, 2020

Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Nov ;36(6):628-632. PMID: 33719271
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation
[+]

Cardamonin induces G2/M arrest and apoptosis via activation of the JNK-FOXO3a pathway in breast cancer cells.Aug 07, 2019

Pubmed Data : Cell Biol Int. 2019 Aug 8. Epub 2019 Aug 8. PMID: 31393045
Article Published Date : Aug 07, 2019
Study Type : In Vitro Study
Additional Links
Substances : Cardamonin
Diseases : Breast Cancer
Pharmacological Actions : Anti-Apoptotic, Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation
[+]

Combination of tanshinone IIA and cisplatin inhibits esophageal cancer.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2020 ;10:1756. Epub 2020 Sep 10. PMID: 33014864
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Esophageal Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, P21 Activation, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Crocetin imparts antiproliferative activity in hepatocellular carcinoma.Sep 11, 2021

Pubmed Data : IUBMB Life. 2021 Sep 12. Epub 2021 Sep 12. PMID: 34514729
Article Published Date : Sep 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor, Survivin Down-Regulation, Vascular Endothelial Growth Factor Inhibitors
[+]

Crocin has therapeutic and preventive effects on cancer cell lines.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2020 Jan ;23(1):3-12. PMID: 32405344
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Crocin
Diseases : Breast Cancer, Colorectal Cancer, Leukemia: Chronic myelogenous leukemia (CML) , Pancreatic Cancer, Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Telomerase Inhibitor
[+]

Cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis in human colorectal cancer cell lines.Jul 15, 2015

Pubmed Data : Hum Exp Toxicol. 2015 Jul 16. Epub 2015 Jul 16. PMID: 26183715
Article Published Date : Jul 15, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Chemotherapeutic Synergy: Gefitinib
[+]

Cucurbitacin B induced S phase arrest and apoptosis in BEL-7402 hepatocellular carcinoma cells.Jul 31, 2010

Pubmed Data : Cancer Lett. 2010 Aug 1 ;294(1):118-24. Epub 2010 Feb 11. PMID: 20153103
Article Published Date : Jul 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Cucurbitacin B proved to be a potential cancer therapeutic agent, in part by inducing hypermethylation and silences the oncogenic activation.Feb 28, 2019

Pubmed Data : Planta Med. 2019 Mar ;85(5):370-378. Epub 2018 Nov 21. PMID: 30463098
Article Published Date : Feb 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Cyclin D1 Down-Regulation, Survivin Down-Regulation
[+]

Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(7):e103760. Epub 2014 Jul 29. PMID: 25072848
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin E
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, Survivin Down-Regulation
[+]

Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells.Dec 31, 2018

Pubmed Data : Phytomedicine. 2019 Jan ;52:117-128. Epub 2018 Sep 28. PMID: 30599890
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Quercetin
Diseases : Breast Cancer, Colorectal Cancer, Lung Cancer, Melanoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Natural Substance Synergy
[+]

Curcumin demonstrates promising therapeutic potential as a new treatment modality for head and neck cancer management.Oct 26, 2015

Pubmed Data : ACS Comb Sci. 2015 Oct 27. Epub 2015 Oct 27. PMID: 26505786
Article Published Date : Oct 26, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Head and Neck Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin
[+]

Cyanidin-3-O-glucoside chloride exhibits cytotoxicity on Caco-2 cells in vitro and induces apoptosis in Caco-2 cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(7). Epub 2016 Jun 23. PMID: 27347927
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cyanidin 3-glucoside, Molasses
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest, Cyclin D1 Down-Regulation, Cytotoxic
[+]

Daidzein may prove beneficial in the development of melanoma systemic therapy. Dec 31, 2019

Pubmed Data : J BUON. 2020 Jan-Feb;25(1):485-490. PMID: 32277673
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Daidzein
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Damnacanthal has potential to be a candidate for the development of chemoprevention or therapeutic agents for cancers.Apr 30, 2016

Pubmed Data : Life Sci. 2016 May 1 ;152:60-6. Epub 2016 Mar 24. PMID: 27018445
Article Published Date : Apr 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Damnacanthal
Diseases : Breast Cancer, Cancers: All, Colorectal Cancer, Prostate Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Chemotherapeutic, Cyclin D1 Down-Regulation
[+]

DIM downregulates cyclin D1 through triggering ER stress in human colorectal cancer cells.Jun 30, 2017

Pubmed Data : Oncol Rep. 2017 Jul ;38(1):569-574. Epub 2017 Jun 1. PMID: 28586058
Article Published Date : Jun 30, 2017
Study Type : In Vitro Study
Additional Links
Diseases : Colorectal Cancer
Pharmacological Actions : Cyclin D1 Down-Regulation
[+]

Eckol inhibits Reg3A-induced proliferation of human SW1990 pancreatic cancer cells.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Oct ;18(4):2825-2832. Epub 2019 Aug 14. PMID: 31572529
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Phlorotannins
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation
[+]

Fisetin inhibits the growth and migration in the A549 human lung cancer cell line.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Mar ;15(3):2667-2673. Epub 2017 Dec 21. PMID: 29467859
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Ganoderma lucidum put forth anti-tumor activity against PC-3 prostate cancer cells.Sep 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2020 Oct ;27(10):2632-2637. Epub 2020 Jun 3. PMID: 32994721
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation, STAT3 Inhibitor
[+]

Genistein induced cell cycle G2/M arrest in human salivary adenoid cystic carcinoma cell line SACC-83.Jan 31, 2006

Pubmed Data : Shanghai Kou Qiang Yi Xue. 2006 Feb ;15(1):69-72. PMID: 16525614
Article Published Date : Jan 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Head and Neck Cancer, Salivary Gland Adenoid Cystic Carcinoma., Salivary Gland Diseases
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression.Apr 30, 2018

Pubmed Data : Mol Med Rep. 2018 May ;17(5):7265-7273. Epub 2018 Mar 16. PMID: 29568950
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Wnt/β-catenin signaling pathway modulation
[+]

Ginkgolide B from ginkgo biloba has an antiproliferative and apoptosis-Inducing effect on ovarian cancer cellsApr 13, 2012

Pubmed Data : Integr Cancer Ther. 2012 Apr 13. Epub 2012 Apr 13. PMID: 22505596
Article Published Date : Apr 13, 2012
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-8 activation, Chemosensitizer, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Natural Substances Versus Drugs, Plant Extracts
Problem Substances : Cisplatin
[+]

Grape seed procyanidin extract inhibits cell proliferation by inducing cell cycle arrest and apoptosis in BIU87 cells.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur Rev Med Pharmacol Sci. 2016 Jul ;20(15):3282-91. PMID: 27467005
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Grape Seed Extract
Diseases : Bladder Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, Survivin Down-Regulation
Additional Keywords : Plant Extracts
[+]

Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells.Dec 31, 2012

Pubmed Data : Am J Chin Med. 2013 ;41(6):1439-57. PMID: 24228611
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus, Polyphenols
Diseases : Leukemia
Pharmacological Actions : Apoptotic, Bax/Bcl2 ratio: Increase, Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Hispolon induces apoptosis against prostate DU145 cancer cells via modulation of mitochondrial and STAT3 pathways.Aug 31, 2019

Pubmed Data : Pak J Pharm Sci. 2019 Sep ;32(5(Supplementary)):2237-2243. PMID: 31894049
Article Published Date : Aug 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus, Polyphenols
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cyclin D1 Down-Regulation, STAT3 Inhibitor
[+]

Huaier extract causes HCC cell apoptosis and induces hepatocellular carcinoma cells arrest in S phase.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:171356. Epub 2015 Jun 28. PMID: 26229542
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Huaier (Trametes robiniophila murr)
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Dose Response, Plant Extracts
[+]

Inhibition of NF-kappaB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel.Apr 30, 2009

Pubmed Data : Arch Pharm Res. 2009 May ;32(5):755-65. Epub 2009 May 27. PMID: 19471891
Article Published Date : Apr 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Inhibitory effects of nobiletin and its major metabolites on lung tumorigenesis.Oct 29, 2019

Pubmed Data : Food Funct. 2019 Oct 30. Epub 2019 Oct 30. PMID: 31664275
Article Published Date : Oct 29, 2019
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive, Cyclin D1 Down-Regulation, P21 Activation
[+]

Isoliquiritigenin could be a promising agent for preventing hepatocellular carcinoma tumorigenesis and metastasis.Jan 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Rep. 2020 01 31 ;40(1). PMID: 31840737
Article Published Date : Jan 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclin D1 Down-Regulation
[+]

Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function.Dec 14, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2016 Dec 15 ;313:204-214. Epub 2016 Oct 3. PMID: 27702603
Article Published Date : Dec 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Pituitary Tumours
Pharmacological Actions : Antiproliferative , Chemopreventive, Cyclin D1 Down-Regulation
[+]

Kahweol-mediated cyclin D1 degradation may contribute to the inhibition of the proliferation in human colorectal cancer cells.Aug 31, 2016

Pubmed Data : Food Chem Toxicol. 2016 Sep ;95:142-8. Epub 2016 Jul 14. PMID: 27424123
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Kahweol
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation
[+]

Lycopene and β-carotene may act as potent anti-proliferative agents in ESCC cells.Apr 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2018 May ;15(5):6727-6732. Epub 2018 Mar 5. PMID: 29731858
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : beta-Carotene, Lycopene
Diseases : Esophageal Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Cyclooxygenase 2 Inhibitors, P21 Activation
[+]

Major triterpenoids in Chinese hawthorn inhibited proliferation and induced apoptosis in MDA-MB-231 cancer cells.Jan 31, 2017

Pubmed Data : Food Chem Toxicol. 2017 Feb ;100:149-160. Epub 2016 Dec 23. PMID: 28025124
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hawthorn, Ursolic Acid
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Caspase-3 Activation, Caspase-9 Activation, Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Antiproliferative, Breast Cancer: Triple Negative, Dose Response, Hawthorn, Ursolic Acid
[+]

Naringenin inhibited the cell proliferation in HCT116 and SW480 cells and decreased the level of cyclin D1 protein.Jun 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 Jul ;23(4):339-44. Epub 2015 Jul 1. PMID: 26157550
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Naringenin
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation
[+]

Nimbolide exhibits anticancer effect by reducing tumor size, tumor burden and by suppressing cell cycle progression in liver cancer.Dec 06, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2020 Dec 7 ;26(45):7131-7152. PMID: 33362373
Article Published Date : Dec 06, 2020
Study Type : In Vitro Study
Additional Links
Substances : Neem
Diseases : Inflammation, Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclin D1 Down-Regulation, NF-kappaB Inhibitor
[+]

Nobiletin may have potential for treating glioblastoma multiforme.Nov 11, 2015

Pubmed Data : Phytother Res. 2015 Nov 12. Epub 2015 Nov 12. PMID: 26560814
Article Published Date : Nov 11, 2015
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Quercetin reduces cyclin D1 activity and induces G1 phase arrest in HepG2 cells.Jun 30, 2016

Pubmed Data : Oncol Lett. 2016 Jul ;12(1):516-522. Epub 2016 May 27. PMID: 27347174
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Quercetin suppresses breast cancer stem cells.Jan 15, 2018

Pubmed Data : Life Sci. 2018 Jan 16. Epub 2018 Jan 16. PMID: 29355544
Article Published Date : Jan 15, 2018
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Cancer Stem Cells
[+]

Resveratrol induces programmed cell death and cell cycle arrest of human bladder cancer cells.Feb 01, 2010

Pubmed Data : Cancer Sci. 2010 Feb;101(2):488-93. Epub 2009 Oct 27. PMID: 20028382
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Bladder Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, Cyclin-Dependent Kinase 4 Down-Regulation, P21 Activation, Phosphorylated Rb Down-Regulation
[+]

Rheum palmatum extract exerts anti-hepatocellular carcinoma effects by inhibiting signal transducer and activator of transcription 3 signaling.Mar 24, 2019

Pubmed Data : J Ethnopharmacol. 2019 Mar 25 ;232:62-72. Epub 2018 Dec 13. PMID: 30553869
Article Published Date : Mar 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Rhubarb
Diseases : Liver Cancer
Pharmacological Actions : Anti-metastatic, Bcl-2 protein down-regulation, Bcl-xL down-regulation, Cyclin D1 Down-Regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor, Survivin Down-Regulation
Additional Keywords : Plant Extracts
[+]

Saikosaponin D inhibits proliferation of human osteosarcoma cells via the p53 signaling pathway.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Jan ;17(1):488-494. Epub 2018 Nov 14. PMID: 30651826
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Tumor Suppressor Protein p53 Upregulation
[+]

Sanguinarine as a potent inhibitor of dihydrofolate reductase, able to impair enzyme activity even in methotrexate resistant MDA-MB-231 cells.Jul 31, 2014

Pubmed Data : Biochem Pharmacol. 2014 Aug 1 ;90(3):226-34. Epub 2014 May 27. PMID: 24875448
Article Published Date : Jul 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bloodroot
Diseases : Breast Cancer, Breast Cancer: Drug Resistant, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 Down-Regulation, Enzyme Inhibitors
Additional Keywords : Bloodroot, Breast Cancer, Breast Cancer: Drug Resistant, Breast Cancer: Triple Negative, Dose Response
[+]

Sasa veitchii extract induces anticancer effects via inhibition of cyclin D1 expression in MCF-7 cells.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nagoya J Med Sci. 2020 Aug ;82(3):509-518. PMID: 33132435
Article Published Date : Jul 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Bamboo
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Cyclin D1 Down-Regulation
[+]

Several pomegranate phytochemicals exhibited synergistic effects in suppressing growth of tumor cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015;20(12):22315-22328. Epub 2015 Dec 12. PMID: 26703530
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer, Breast Cancer: Chemically-Induced, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclin D1 Down-Regulation, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Natural Substance Synergy
[+]

Spica Prunellae inhibits the proliferation of colon cancer cells through G1/S cell cycle arrestSep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncol Lett. 2013 Oct ;6(4):1123-1127. Epub 2013 Aug 5. PMID: 24137475
Article Published Date : Sep 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Prunella vulgaris
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Dose Response, Plant Extracts
[+]

Synergistic growth inhibitory effects of chrysin and metformin combination on breast cancer cells.Apr 24, 2018

Pubmed Data : Asian Pac J Cancer Prev. 2018 Apr 25 ;19(4):977-982. Epub 2018 Apr 25. PMID: 29693804
Article Published Date : Apr 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Chrysin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Tetrahydrocurcumin can synergistically enhance the radiosensitivity of glioma cells.May 31, 2018

Pubmed Data : J Pharm Pharmacol. 2018 Jun ;70(6):749-759. Epub 2018 Mar 1. PMID: 29492979
Article Published Date : May 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Tetrahydrocurcumin
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, Radiosensitizer
[+]

These findings highlight the potential use of resveratrol as an adjuvant therapy for breast cancer.May 31, 2016

Pubmed Data : Oncol Rep. 2016 Jun ;35(6):3696-704. Epub 2016 Apr 4. PMID: 27109433
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
Additional Keywords : Gene Expression Regulation
[+]

These findings indicate that fisetin is a promising antitumor agent against renal cell carcinoma.Aug 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2019 Aug 21 ;8(9). Epub 2019 Aug 21. PMID: 31438640
Article Published Date : Aug 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Kidney Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, Matrix metalloproteinase-9 (MMP-9) inhibitor, P21 Activation
[+]

These results shed light on berberine's potential as an anti-tumor agent for clinical cancer therapy.Nov 14, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 Nov 15 ;17(11). Epub 2016 Aug 15. PMID: 27854312
Article Published Date : Nov 14, 2016
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Liver Cancer
Pharmacological Actions : Cyclin D1 Down-Regulation
Additional Keywords : Dose Response
[+]

These results signify that Aloe vera may be an effective anti-neoplastic agent to inhibit cancer cell growth and increase the therapeutic efficacy of conventional drugs like cisplatin.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(7):2939-46. PMID: 25854386
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Aloe Vera
Diseases : Breast Cancer, Cervical Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Chemopreventive, Chemotherapeutic, Cyclin D1 Down-Regulation
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Ursolic acid can effectively inhibit the proliferation of osteosarcoma cell line U2-OS.Oct 31, 2017

Pubmed Data : Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Nov 1 ;31(11):1371-1376. PMID: 29798594
Article Published Date : Oct 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Osteosarcoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Viscum album var showed evidence of anti-cancer activity through G1 phase cell cycle arrest in SK-Hep1 cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2015 ;16(15):6417-21. PMID: 26434853
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Mistletoe
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation
Additional Keywords : Plant Extracts
[+]

Vitamin C affects G0/G1 cell cycle and autophagy by downregulating of cyclin D1 in gastric carcinoma cells.Feb 23, 2021

Pubmed Data : Biosci Biotechnol Biochem. 2021 Feb 24 ;85(3):553-561. PMID: 33624781
Article Published Date : Feb 23, 2021
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Gastric Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Autophagy Up-regulation, Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Wogonin inhibits cell cycle progression by activating the glycogen synthase kinase-3 beta in hepatocellular carcinoma.Jan 17, 2020

Pubmed Data : Phytomedicine. 2020 Jan 18 ;68:153174. Epub 2020 Jan 18. PMID: 31991293
Article Published Date : Jan 17, 2020
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Cyclin D1 Down-Regulation
[+]

Wogonin inhibits the proliferation of myelodysplastic syndrome cells.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Nov ;12(5):7285-92. Epub 2015 Sep 23. PMID: 26398525
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Wogonin
Diseases : Myelodysplastic Syndrome
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation

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