Cyclooxygenase 1 Inhibitor

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58 Substances Researched for Cyclooxygenase 1 Inhibitor
NameACCKFocus
Flavonoids58Locked
Curcumin77Locked
Lignans36Locked
Resveratrol56Locked
Omega-3 Fatty Acids35Locked
Seaweed: Brown 15Locked
Flaxseed24Locked
Alpha-Lipoic Acid12Locked
Apigenin12Locked
Astragaloside12Locked
Cannabinoids 22Locked
Carrot12Locked
Fucoidan12Locked
Goldenrod12Locked
Graviola 12Locked
Myricetin12Locked
Orthosiphon12Locked
Parthenolide12Locked
Pycnogenol (Pine Bark)12Locked
Rose 22Locked
Ruta Graveolens12Locked
Rutin12Locked
Schisandra12Locked
Stilbenes12Locked
Bamboo11Locked
Biochanin A11Locked
Black Pepper11Locked
Butterbur11Locked
Cannabidiol11Locked
Cannabigerol 11Locked
Celery seed11Locked
Cherry: All Varieties11Locked
Cissus quadrangularis11Locked
Daisy11Locked
EGCG (Epigallocatechin gallate)11Locked
Ellagic Acid11Locked
Fermented Foods and Beverages11Locked
Fish Oil11Locked
Frankincense11Locked
Ginkgo biloba11Locked
Hazelnut 11Locked
Homeopathic Medicine: All11Locked
Kava Kava11Locked
Lavender: Essential Oil11Locked
Licorice11Locked
Mistletoe11Locked
Mussel: Green-lipped (Perna canaliculus)11Locked
Nasturtium 11Locked
Nigella sativa (aka Black Seed)11Locked
Olive11Locked
Olive Oil11Locked
Plantago11Locked
Plantago lanceolata11Locked
Plantago major11Locked
Polyphenols11Locked
Pterostilbene11Locked
Shallot11Locked
Wheat Germ11Locked

View the Evidence:
60 Abstracts with Cyclooxygenase 1 Inhibitor Research

[+]

Marine alga Ecklonia cava extract and dieckol attenuate prostaglandin E2 production in HaCaT keratinocytes exposed to airborne particulate matter.Jun 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Jun 21 ;8(6). Epub 2019 Jun 21. PMID: 31234405
Article Published Date : Jun 20, 2019
Study Type : Human In Vitro
Additional Links
Substances : Seaweed: Brown
Diseases : Air Pollution Linked Toxicity, Lung Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.Jan 31, 2019

Pubmed Data : Cancer Lett. 2019 Feb 1 ;448:20-30. Epub 2019 Feb 1. PMID: 30716361
Article Published Date : Jan 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Alpha-lipoic acid is a promising agent for attenuating inflammation and preventing steatohepatitis.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Biochem Biophys. 2023 Dec ;750:109811. Epub 2023 Nov 4. PMID: 37926405
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Fatty Liver, High Fat Diet, Inflammation, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Hepatoprotective
[+]

Apigenin and myricetin exhibited a protective and promising preventive strategy against cisplatin-induced nephrotoxicity.Nov 30, 2017

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):766-774. PMID: 28064632
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Apigenin, Flavonoids, Myricetin
Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress
Pharmacological Actions : Chemoprotective Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Astragaloside IV protects rat gastric mucosa against aspirin-induced damage.Nov 30, 2016

Pubmed Data : Int Immunopharmacol. 2016 Dec ;41:47-55. Epub 2016 Nov 2. PMID: 27816726
Article Published Date : Nov 30, 2016
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Gastroprotective, Superoxide Dismutase Up-regulation
Problem Substances : Aspirin
[+]

Carrot seeds contain phytochemicals capable of inhibiting inflammatory enzymes.Jun 01, 2007

Pubmed Data : Carcinogenesis. 2007 Jun;28(6):1188-96. Epub 2006 Dec 6. PMID: 13680840
Article Published Date : Jun 01, 2007
Study Type : Animal Study
Additional Links
Substances : Carrot
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Dietary flaxseed may be chemopreventive for intestinal and colon tumor development in mice possibly by increasing omega -3 fatty acid levels, lignans, and decreasing COX-1 and COX-2 levels.Jan 01, 2009

Pubmed Data : Nutr Cancer. 2009;61(2):276-83. PMID: 19235044
Article Published Date : Jan 01, 2009
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans, Omega-3 Fatty Acids
Diseases : Colon Cancer, Intestinal Cancer
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Dietary flaxseed meal containing high levels of omega-3 fatty acids and lignans is effective in preventing colon tumor development when compared with dietary corn meal possibly by increasing omega-3 fatty acid levels and decreasing COX-1 and COX-2 levels.Jan 01, 2006

Pubmed Data : Nutr Cancer. 2006;54(2):216-22. PMID: 16898866
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Lignans, Omega-3 Fatty Acids
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063
Article Published Date : Jan 31, 2011
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
Problem Substances : Aspirin
Adverse Pharmacological Actions : Ulcerogenic
[+]

Graviola possesses analgesic effects through interaction with opioidergic pathway and anti-inflammatory properties through inhibition of chemical mediators of inflammation.Nov 30, 2014

Pubmed Data : J Med Food. 2014 Dec ;17(12):1375-82. PMID: 25133801
Article Published Date : Nov 30, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Graviola
Diseases : Arthritis, Rheumatism
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Natural Substances Versus Drugs
Problem Substances : Carrageenan
[+]

Orthosiphon stamineus tea modulates arthritis pathogenesis.Nov 23, 2016

Pubmed Data : BMC Complement Altern Med. 2016 Nov 24 ;16(1):480. Epub 2016 Nov 24. PMID: 27881135
Article Published Date : Nov 23, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids, Orthosiphon
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Parthenolide alleviates indomethacin-induced gastric ulcerMay 03, 2024

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2024 May 4. Epub 2024 May 4. PMID: 38703207
Article Published Date : May 03, 2024
Study Type : Animal Study
Additional Links
Substances : Parthenolide
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pycnogenol reduced the toxic effect of indomethacin on the stomach and increased anti-inflammatory activity.Aug 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gen Physiol Biophys. 2022 Sep ;41(5):473-481. PMID: 36222345
Article Published Date : Aug 31, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Pycnogenol (Pine Bark)
Diseases : Drug-Induced Toxicity: Indomethacin
Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Gastrointestinal Agents, Gastroprotective, Malondialdehyde Down-regulation
Additional Keywords : Natural Substance/Drug Synergy, Plant Extracts
Problem Substances : Indomethacin
[+]

Resveratrol, a compound found within grapes, prevents chemically-induced breast and skin cancer.Dec 28, 1984

Pubmed Data : Biochem Biophys Res Commun. 1984 Dec 28;125(3):996-1004. PMID: 8985016
Article Published Date : Dec 28, 1984
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Breast Cancer, Inflammation, Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antimutagenic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase Inhibitors, Hydroperoxidase Inhibitor, Phase II Detoxification Enzyme Inducer
[+]

Ruta graveolens extract had anti-inflammatory and antioxidant activity, with potent inhibitory effects on the arachidonic acid pathways.Feb 28, 2014

Pubmed Data : Chin J Nat Med. 2014 Mar ;12(3):172-9. PMID: 24702802
Article Published Date : Feb 28, 2014
Study Type : Animal Study
Additional Links
Substances : Ruta Graveolens
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Rutin exhibits significant physiological, biochemical and immunological protection against Methotrexate induced intestinal toxicity.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2016 ;16:99. Epub 2016 Mar 10. PMID: 26965456
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Rutin
Diseases : Drug-Induced Toxicity: Methotrexate
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Solidagenone from Solidago chilensis Meyen inhibits skin inflammation in experimental models.Dec 31, 2020

Pubmed Data : Basic Clin Pharmacol Toxicol. 2021 Jan ;128(1):91-102. Epub 2020 Sep 2. PMID: 32780565
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Goldenrod
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Targeted lignan profiling and anti-inflammatory properties of Schisandra rubriflora and Schisandra chinensis extracts.Nov 26, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Nov 27 ;23(12). Epub 2018 Nov 27. PMID: 30486445
Article Published Date : Nov 26, 2018
Study Type : Animal Study
Additional Links
Substances : Lignans, Schisandra
Diseases : Inflammation
Pharmacological Actions : 15-Lipoxygenase (15-LOX) Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

An in-vitro test of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) inhibition potency verified that both Plantago lanceolata and P. major exhibit considerable anti-inflammatory activity.Sep 05, 2010

Pubmed Data : J Pharm Biomed Anal. 2010 Sep 5 ;52(5):701-6. Epub 2010 Feb 18. PMID: 20219312
Article Published Date : Sep 05, 2010
Study Type : In Vitro Study
Additional Links
Substances : Plantago lanceolata, Plantago major
Diseases : Inflammation
Pharmacological Actions : 12-lipoxygenase (12-LOX), Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase Inhibitors
Additional Keywords : Plant Extracts
[+]

Anti-inflammatory activity of olive oil polyphenols.Nov 20, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2022 Nov 21 ;10(11). Epub 2022 Nov 21. PMID: 36428559
Article Published Date : Nov 20, 2022
Study Type : In Vitro Study
Additional Links
Substances : Olive Oil, Polyphenols
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Anti-inflammatory and anti-cancer activities of frankincense.Feb 03, 2020

Pubmed Data : Semin Cancer Biol. 2020 Feb 4. Epub 2020 Feb 4. PMID: 32027979
Article Published Date : Feb 03, 2020
Study Type : Review
Additional Links
Substances : Frankincense
Diseases : Edema, Glioma
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-metastatic, Antioxidants, Antiproliferative , Cell cycle arrest, Chemotherapeutic, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens seeds.Apr 30, 2002

Pubmed Data : Phytomedicine. 2002 May ;9(4):312-8. PMID: 12120812
Article Published Date : Apr 30, 2002
Study Type : In Vitro Study
Additional Links
Substances : Celery seed
Diseases : Cancers: All
Pharmacological Actions : Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, Topoisomerase I inhibitor, Topoisomerase II Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Asteraceae have anti-inflammatory activities, which could be exerted by inhibiting the cyclooxygenase-1 and 5-lipoxygenase enzymes.Jul 29, 2015

Pubmed Data : Planta Med. 2015 Jul 30. Epub 2015 Jul 30. PMID: 26227502
Article Published Date : Jul 29, 2015
Study Type : In Vitro Study
Additional Links
Substances : Daisy
Diseases : Inflammation
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor
Additional Keywords : Plant Extracts
[+]

Bamboo extracts exhibited anti-inflammatory properties by inhibiting NF-κB-induced gene expression.Jan 31, 2014

Pubmed Data : Phytother Res. 2014 Feb ;28(2):224-30. Epub 2013 Apr 5. PMID: 23559516
Article Published Date : Jan 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Bamboo
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Biochanin A is an attractive compound for preventing 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced wasting syndrome.Dec 31, 2018

Pubmed Data : J Environ Sci Health A Tox Hazard Subst Environ Eng. 2019 ;54(9):865-873. Epub 2019 Apr 20. PMID: 31007129
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Chronic Wasting Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Prostaglandin PGE2 downregulation
[+]

Butterbur (P. hybridus) exhibits ant-inflammatory activity in rat microglial (brain) cells. Jan 01, 2005

Pubmed Data : Planta Med. 2005 Jan;71(1):12-9. PMID: 15678367
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Butterbur
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Cannabigerol as an anti-inflammatory agent altering the level of arachidonic acid derivatives in the colon tissue of rats subjected to a high-fat high-sucrose diet.Aug 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2024 Sep ;178:117286. Epub 2024 Aug 11. PMID: 39128189
Article Published Date : Aug 31, 2024
Study Type : In Vitro Study
Additional Links
Substances : Cannabigerol , Cannabinoids
Diseases : Colitis, High Fat Diet, High Sugar Diet, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Cannabinoids may have a role to play in arthritis prevention and treatment. Feb 28, 2006

Pubmed Data : J Pharm Pharmacol. 2006 Mar ;58(3):351-8. PMID: 16536902
Article Published Date : Feb 28, 2006
Study Type : Review
Additional Links
Substances : Cannabinoids
Diseases : Arthritis
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Celecoxib and curcumin work synergistically to inhibit the growth of colorectal cancer cells.Sep 15, 2005

Pubmed Data : Clin Cancer Res. 2005 Sep 15;11(18):6738-44. PMID: 16166455
Article Published Date : Sep 15, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer, Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Prostaglandin PGE2 downregulation
Additional Keywords : Drug: Celecoxib, Drug Synergy
[+]

Chilean hazelnuts can be considered a source of health promoting compounds.Nov 14, 2019

Pubmed Data : Food Chem. 2019 Nov 15 ;298:125026. Epub 2019 Jun 15. PMID: 31260961
Article Published Date : Nov 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hazelnut
Diseases : Inflammation, Metabolic Diseases, Oxidative Stress
Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Clinical studies have reported that oral fish oil supplementation has beneficial effects in rheumatoid arthritis and among some asthmatics, supporting the idea that the n-3 FA in fish oil are anti-inflammatoryMar 31, 2003

Pubmed Data : Lipids. 2003 Apr ;38(4):343-52. PMID: 12848278
Article Published Date : Mar 31, 2003
Study Type : Review
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Asthma, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Curcumin exhibits anti-cancer, anti-inflammatory and antioxidant activities.Jul 01, 2000

Pubmed Data : Phytomedicine. 2000 Jul;7(4):303-8. PMID: 10969724
Article Published Date : Jul 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer, Colon Cancer, Kidney Cancer, Melanoma
Pharmacological Actions : Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Curcumin inhibits cell migration of human colon cancer cells.Mar 01, 2006

Pubmed Data : Anticancer Res. 2006 Mar-Apr;26(2A):1281-8. PMID: 16619535
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancer Metastasis, Colon Cancer
Pharmacological Actions : Antineoplastic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Curcumin may be effective for the prevention of severe lower respiratory tract disease in infants and young children.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(9):e70225. Epub 2013 Sep 18. PMID: 24058438
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Respiratory Syncytial Virus Infections
Pharmacological Actions : Antiviral Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Proteasome Inhibitors
[+]

Curcumin reduces inflammation and carcinogensis associated with arachidonic acid metabolism. Jul 01, 2009

Pubmed Data : J Nutr. 2009 Jul;139(7):1273-8. Epub 2009 May 20. PMID: 15073046
Article Published Date : Jul 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antineoplastic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors
[+]

Curcumin works synergistically with celecoxib to potentiate a growth-inhibitory and pro-apoptotic in osteoarthritis synovial adherent cells.Feb 01, 2006

Pubmed Data : Rheumatology (Oxford). 2006 Feb;45(2):171-7. Epub 2005 Oct 25. PMID: 16249246
Article Published Date : Feb 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Osteoarthritis: Knee, Oxidative Stress
Pharmacological Actions : Antioxidants, Antiproliferative , Apoptotic, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Drug: Celecoxib, Drug Synergy
[+]

Curcumin, EGCG and resveratrol inhibit inflammation.Sep 01, 2001

Pubmed Data : Mutat Res. 2001 Sep 1;480-481:243-68. PMID: 11506818
Article Published Date : Sep 01, 2001
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, EGCG (Epigallocatechin gallate), Resveratrol
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor
[+]

Ellagic acid inhibits extracellular acidity-induced invasiveness and expression of COX1, COX2, snail, twist 1, and c-myc in gastric carcinoma cells.Dec 09, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Dec 10 ;11(12). Epub 2019 Dec 10. PMID: 31835645
Article Published Date : Dec 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ellagic Acid
Diseases : Gastric Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Evaluation of antimicrobial and anti-inflammatory activities of seed extracts from six Nigella species.Mar 31, 2009

Pubmed Data : J Med Food. 2009 Apr ;12(2):408-15. PMID: 19459745
Article Published Date : Mar 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Bacterial Infections, Inflammation
Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Antifungal Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and proinflammatory mediators.Jun 13, 2012

Pubmed Data : J Ethnopharmacol. 2012 Jun 14 ;141(3):989-96. Epub 2012 Mar 30. PMID: 22484053
Article Published Date : Jun 13, 2012
Study Type : In Vitro Study
Additional Links
Substances : Cissus quadrangularis
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
Additional Keywords : Plant Extracts
[+]

Exploring the antidiabetic and anti-inflammatory potential of Lavandula officinalis essential oil: In vitro and in silico insights.Aug 14, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2024 Aug 15 ;10(15):e34135. Epub 2024 Jul 5. PMID: 39170293
Article Published Date : Aug 14, 2024
Study Type : In Vitro Study
Additional Links
Substances : Lavender: Essential Oil
Diseases : Diabetes Mellitus: Type 2, Inflammation
Pharmacological Actions : Alpha-amylase inhibitor, Alpha-glucosidase inhibitor , Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Fermented wheat germ extract (avemar) inhibits adjuvant arthritis.Aug 31, 2007

Pubmed Data : Ann N Y Acad Sci. 2007 Sep ;1110:348-61. PMID: 17911450
Article Published Date : Aug 31, 2007
Study Type : In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages, Wheat Germ
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Ginkgolic acid is a multi-Target inhibitor of key enzymes in pro-inflammatory lipid mediator biosynthesis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:797. Epub 2019 Jul 17. PMID: 31379572
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Inflammation
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor
[+]

Green mussel lipid extracts have anti-cyclooxygenase activity superior to fish oil. Mar 01, 2007

Pubmed Data : Comp Biochem Physiol B Biochem Mol Biol. 2007 Mar;146(3):346-56. Epub 2006 Nov 17. PMID: 17197217
Article Published Date : Mar 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Fish Oil, Mussel: Green-lipped (Perna canaliculus)
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
Additional Keywords : Drug: Indomethacin, Green Muscle Lipids Superior to Fish Oil Lipids
[+]

In silico characterisation of olive phenolic compounds as potential cyclooxygenase modulators.Sep 02, 2020

Pubmed Data : J Mol Graph Model. 2020 Sep 3 ;101:107743. Epub 2020 Sep 3. PMID: 32920237
Article Published Date : Sep 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Olive
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B.Aug 01, 2010

Pubmed Data : Nat Prod Commun. 2010 Aug;5(8):1253-7. PMID: 20839630
Article Published Date : Aug 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Black Pepper
Diseases : Tumors
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Antiproliferative , Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Kava contains compounds with Cyclooxygenase enzyme inhibitory and antioxidant properties.Jan 01, 2002

Pubmed Data : Phytomedicine. 2002 Jan;9(1):41-7. PMID: 11924763
Article Published Date : Jan 01, 2002
Study Type : In Vitro Study
Additional Links
Substances : Kava Kava
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(3):e0173628. Epub 2017 Mar 10. PMID: 28282426
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Licorice
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
[+]

Plantago major has COX-2/COX-1 inhibitory activities. Jan 31, 2013

Pubmed Data : Phytochem Anal. 2013 Feb ;24(2):176-83. Epub 2012 Sep 19. PMID: 22991332
Article Published Date : Jan 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Plantago
Diseases : Inflammation
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Pterostilbene is equipotent to resveratrol in inhibiting inflammation, but may be more bioavailable due to its higher lipophilicity.Jun 01, 2008

Pubmed Data : Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S62-70. PMID: 18551458
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene, Resveratrol
Diseases : Inflammation
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, NF-kappaB Inhibitor, Proteasome Inhibitors
Additional Keywords : Stilbenes
[+]

Results show that CBD profoundly inhibits expression of COX-1 and COX-2 mRNA.Aug 04, 2022

Pubmed Data : Cannabis Cannabinoid Res. 2022 Aug 5. Epub 2022 Aug 5. PMID: 35930236
Article Published Date : Aug 04, 2022
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Resveratrol has anti-inflammatory properties. Jul 15, 2010

Pubmed Data : Biochem J. 2010 Jul 15;429(2):273-82. PMID: 20450491
Article Published Date : Jul 15, 2010
Study Type : Review
Additional Links
Substances : Resveratrol
Diseases : Inflammation
Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors
Additional Keywords : Stilbenes
[+]

Resveratrol protect the endothelium against inflammation and injury. Dec 01, 2010

Pubmed Data : Phytother Res. 2010 Dec;24(12):1762-8. PMID: 20564508
Article Published Date : Dec 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Resveratrol
Diseases : Endothelial Dysfunction
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Vasoprotective
Additional Keywords : Stilbenes
[+]

Rosa canina - Rose hip pharmacological ingredients and molecular mechanics counteracting osteoarthritis.May 11, 2019

Pubmed Data : Phytomedicine. 2019 May 12:152958. Epub 2019 May 12. PMID: 31138475
Article Published Date : May 11, 2019
Study Type : Review
Additional Links
Substances : Rose
Diseases : Osteoarthritis
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

Rose crude polysaccharides are very promising and can potentially be used as natural chemopreventive agents.Apr 05, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Apr 6 ;24(7). Epub 2019 Apr 6. PMID: 30959857
Article Published Date : Apr 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Rose
Diseases : Colon Cancer, Lung Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemopreventive, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts, Polysaccharides
[+]

Structural characterization, and antioxidative and anti-inflammatory activities of phylloxanthobilins in Tropaeolum majus.May 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Planta Med. 2024 Jun ;90(7-08):641-650. Epub 2024 Jun 6. PMID: 38843802
Article Published Date : May 31, 2024
Study Type : In Vitro Study
Additional Links
Substances : Nasturtium
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts
[+]

These findings may help to rationalize the wide use of Persian shallot for the treatment of inflammatory disorders.May 27, 2014

Pubmed Data : J Ethnopharmacol. 2014 May 28 ;154(1):176-82. Epub 2014 Apr 8. PMID: 24721027
Article Published Date : May 27, 2014
Study Type : In Vitro Study
Additional Links
Substances : Shallot
Diseases : Inflammation
Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
[+]

These results thus demonstrate that VA-mediated inhibition of PGE2 implicates destabilization of COX-2 mRNA. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(2):e0114965. Epub 2015 Feb 9. PMID: 25664986
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Mistletoe
Diseases : Inflammation, Lung Cancer
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, MicroRNA modulator, Prostaglandin PGE2 downregulation
[+]

This review explores the potential benefits of cherries and cherry products as a nonpharmacologic option for the treatment of gout.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ther Adv Musculoskelet Dis. 2019 ;11:1759720X19847018. Epub 2019 May 17. PMID: 31205513
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Cherry: All Varieties
Diseases : Gout
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Zeel may reduce the main two classes of molecules responsible for arthritic pain and inflammation. Dec 31, 2006

Pubmed Data : Explore (NY). 2007 Jan-Feb;3(1):16-22. PMID: 17234564
Article Published Date : Dec 31, 2006
Study Type : Review
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Arthritis, Inflammation
Pharmacological Actions : 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors
Additional Keywords : Plant Extracts, Randomized Controlled Trials As Topic

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