Cyclooxygenase 2 Inhibitors

Name	AC	CK
Curcumin	76	120
Flavonoids	30	60
Ginsenosides	21	34
Resveratrol	20	31
Frankincense	8	29
Omega-3 Fatty Acids	8	28
Sulforaphane	15	23
Cannabis	7	22
Melatonin	11	22
Polyphenols	14	22
Oleuropein	6	21
Vitamin C	7	20
Phloretin	5	19
Berberine	11	18
Spirulina	5	18
Fisetin	11	16
Thymoquinone	9	16
Turmeric	7	16
Rose	10	15
Cannabinoids	4	13
DHA (Docosahexaenoic Acid)	4	13
Ginseng (Korean)	10	13
Apples	2	12
Astaxanthin	7	12
Quercetin	9	12
Rosmarinic acid	7	12
Sesamin	2	12
Anthocyanins	7	11
Banana	2	11
EPA (Eicosapentaenoic Acid)	2	11
Fucoxanthin	6	11
Grape	6	11
Pomegranate	7	11
Strawberry	2	11
Diosmin	6	10
Eicosapentaenoic acid (EPA)	1	10
Gingerol	6	10
MSM (Methylsulfonylmethane)	1	10
Myricetin	8	10
Tocotrienols	1	10
Ginger	5	9
Hesperidin	5	9
Paeoniflorin	6	9
Adlay	6	8
Chrysin	5	8
Dandelion	6	8
Dogwood	5	8
Geraniol	4	8
Ginkgo biloba	5	8
Lignans	4	8
Lotus	6	8
Nobiletin	6	8
Seaweed: Brown	3	8
Stilbenes	5	8
Tanshinone IIA	7	8
Wogonin	6	8
Bee Venom	5	7
Citrus naringin	5	7
Ellagic Acid	5	7
Fermented Foods and Beverages	6	7
Formononetin	5	7
Grape Seed Extract	4	7
Japanese cypress	4	7
Lycopene	5	7
Mangiferin	5	7
Mulberry	6	7
Noni	4	7
Oleocanthal	3	7
Oligonol	4	7
Patchouli	4	7
Pterostilbene	5	7
Reishi Mushroom	5	7
Zerumbone	4	7
Antrodia camphorata	4	6
Beta-Caryophyllene	4	6
Black Tea	4	6
Cannabidiol	4	6
Honokiol	4	6
Indole-3-Carbinol	3	6
Isoliquiritigenin	4	6
Licorice	3	6
Olive	5	6
Puerarin	4	6
Punicalagin	4	6
Rutin	3	6
Shikonin	3	6
Tetrahydrocurcumin	3	6
Walnut	4	6
Alpha-Lipoic Acid	3	5
Apigenin	3	5
Artesunate	3	5
Carnosol	3	5
Carvacrol	3	5
Catechin	4	5
Citrus Peel	3	5
EGCG (Epigallocatechin gallate)	5	5
Genipin	3	5
Gotu Kola	3	5
Hydroxytyrosol	3	5
Justicia gendarussa	3	5
Luteolin	5	5
Moringa oleifera	3	5
Naringenin	3	5
Nettle	3	5
Palmitoylethanolamide	3	5
Perilla	3	5
Probiotics	3	5
Raspberry	3	5
Red Clover	4	5
Sesamol	3	5
Tangeretin	4	5
Vitex negundo	3	5
Water: Deuterium Depleted	3	5
Apple Polyphenols	2	4
Arginine	2	4
Astragaloside	2	4
Blueberry	3	4
Bromelain	4	4
Brown Rice	2	4
Chaga Mushroom (Inonotus obliquus)	3	4
Cordyceps sinensis	2	4
Crocin	3	4
D-Limonene	2	4
Daidzein	3	4
Delta-tetrahydrocannabinol (THC)	3	4
Ferulic acid	3	4
Flaxseed	2	4
Fucoidan	3	4
Garlic	3	4
Honeysuckle	3	4
Lactobacillus fermentum	2	4
Lactobacillus plantarum	3	4
Lion's Mane (Hericium Erinaceus)	2	4
Lychee	2	4
Magnolol	2	4
Medicinal Mushrooms	3	4
Medium Chain Triglycerides	2	4
Nexrutine (Phellodendrom)	3	4
Nigella sativa (aka Black Seed)	4	4
P-Coumaric Acid	3	4
Paeonol	3	4
Palm Oil	2	4
Peony	3	4
Piceatannol	3	4
Piperlongumine	3	4
Rice Bran	2	4
Royal Jelly	2	4
Saffron	3	4
Saturated fatty acids	2	4
Sea buckthorn	2	4
Sweet Potato: Purple	2	4
Toona sinensis	3	4
Ursolic Acid	4	4
Vitamin D	2	4
Vitamin E	2	4
White Tea	2	4
18β-Glycyrrhetinic Acid	2	3
Aduki bean	2	3
Arctigenin	2	3
Asiatic Acid	2	3
Avocado	2	3
Bee Propolis	2	3
Bitter Melon	3	3
Bitter Orange	3	3
Caffeic acid phenethyl ester	2	3
Chamomile	2	3
Chinese Skullcap	2	3
Crocetin	2	3
Diosgenin	2	3
Eriodictyol	2	3
Gastrodin	2	3
Genistein	3	3
Ginseng (American)	2	3
Honey	2	3
Hops	2	3
Isoflavones	2	3
Isothiocyanates	2	3
Kimchi	3	3
Lupeol	2	3
Maitake Mushroom	2	3
Olive leaf extract	2	3
Phellinus Linteus	2	3
Polyunsaturated Fatty Acids (PUFAs)	2	3
Red Sage	2	3
Rosemary	2	3
Safflower	2	3
Silibinin	2	3
Tocotrienol: Gamma	2	3
5-HTP (5-Hydroxytryptophan)	1	2
6-Shogaol	1	2
ALA (Alpha-Linolenic Acid)	1	2
Acai	1	2
African Basil	1	2
Agaricus Blazei	1	2
Alpha Linolenic Acid	1	2
Angelica	2	2
Apocynin	1	2
Apple	1	2
Artemisia asiatica	1	2
Artemisinin	2	2
Asparagus	2	2
Bai Zhu	1	2
Barley	1	2
Benzyl isothiocyanate	1	2
Bergamot	1	2
Betulinic acid	2	2
Black Currant	1	2
Boswellia	1	2
Brazil nut	1	2
Burdock	1	2
Butterbur	2	2
Camel Milk	1	2
Cardamonin	1	2
Carrot	1	2
Chickpea	2	2
Chlorogenic Acid	1	2
Chokeberry	1	2
Chrysanthemum Indicum	2	2
Chrysanthemum Morifolium	2	2
Citrus Oils	1	2
Cocoa	1	2
Coptis chinensis	1	2
Cordyceps Militaris	1	2
Corn: Purple	1	2
Cranberry	1	2
Curry Tree	1	2
Cyanidin 3-glucoside	1	2
Damnacanthal	1	2
Delphinidin	1	2
Demethoxycurcumin	1	2
Emodin	1	2
Evening Primrose Oil	1	2
Gallic Acid	1	2
Garcinia indica	1	2
Gardenia	1	2
Ginseng	1	2
Ginseng (Siberian)	1	2
Gold (nanoparticles)	1	2
Graviola	1	2
Green Tea	1	2
Guggul	2	2
Hazelnut	2	2
Hemp Seed	1	2
Horseradish	2	2
Hu Zhang (Polygonum cuspidatum)	1	2
Hydrogen Water	1	2
Isoquercitrin	1	2
Kaempferia parviflora	1	2
Kaempferol	1	2
Krill	1	2
L-Carnitine	1	2
Lactobacillus paracasei	1	2
Lactobacillus rhamnosus	1	2
Lavender	1	2
Ligustrazine	1	2
Loquat	1	2
Magnolia	1	2
Manuka Honey	1	2
Mint	1	2
Myo-inositol	1	2
Noni leaf extract	1	2
Nutmeg	1	2
Oak	1	2
Orange	1	2
Panax Ginseng	1	2
Papaya	1	2
Paprika	1	2
Pau D'Arco	1	2
Pelargonium sidoides	1	2
Peppermint	1	2
Pine Needle	1	2
Pineapple	1	2
Plantago asiatica	1	2
Polypodium leucotomos	1	2
Poria cocos	2	2
Potato	1	2
Psychedelics:All	2	2
Raspberry ketone	1	2
Red Wine	1	2
Rosemaric Acid	1	2
Ruta Graveolens	1	2
Schisandra	1	2
Selenium	1	2
Shiitake Mushroom	1	2
Sour Cherry	1	2
Taurine	1	2
Tea	1	2
Theaflavins	2	2
Thistle	1	2
Thuja	1	2
Thymol	1	2
Tongkat Ali	1	2
Turmeric: Fermented	1	2
Urolithin A	1	2
Vanillin	2	2
Verbascoside	2	2
Vinegar	1	2
Watermelon	1	2
Wheat Germ	2	2
Xanthohumol	1	2
Yam	1	2
Yeast	1	2
Yoghurt	1	2
Zeaxanthin	1	2
acetyl-11-keto-beta-boswellic acid	1	2
Achillea fragrantissima	1	1
Almond	1	1
Amla Fruit	1	1
Amygdalin (laetrile)	1	1
Apple Pectin	1	1
Ashwagandha	1	1
Avacado	1	1
Avenanthramides	1	1
Baicalein	1	1
Bamboo	1	1
Beet	1	1
Beta-glucan	1	1
Bifidobacterium Breve	1	1
Biochanin A	1	1
Black Pepper	1	1
Black Raspberry	1	1
Capsaicin	1	1
Carnosic Acid	1	1
Celastrol	1	1
Celery	1	1
Celery seed	1	1
Cherry: All Varieties	1	1
Chlorella (Algae)	1	1
Citric Acid	1	1
Coenzyme Q10	1	1
Coumestrol	1	1
Cucurbitacin B	1	1
Cumin	1	1
Cyanidin	1	1
Deguelin	1	1
Echinacea	1	1
Eugenol	1	1
False Black Pepper	1	1
Feverfew	1	1
Fish Oil	1	1
Fruit: All	1	1
Gleditsia sinensis	1	1
Glycyrrhizin	1	1
Green Coffee Bean	1	1
Guava	1	1
Homeopathic Medicine: All	1	1
Huperzine	1	1
Hyaluronic Acid	1	1
Jujube	1	1
Kahweol	1	1
Kava Kava	1	1
Lactobacillus reuteri	1	1
Lactobacillus rhamnosus GG	1	1
Long Pepper	1	1
Loquat Leaves	1	1
Lutein	1	1
Macadamia	1	1
Maqui	1	1
Mastic gum	1	1
Modified Citrus Pectin	1	1
Mushrooms: All	1	1
Mussel: Green-lipped (Perna canaliculus)	1	1
Nuts	1	1
Oats	1	1
Olive Oil	1	1
Onion	1	1
Orange: Mandarin	1	1
Oranges	1	1
Oridonin	1	1
Orthosiphon	1	1
Panax Notoginseng	1	1
Parthenolide	1	1
Passion Flower	1	1
Pea	1	1
Persimmon	1	1
Phenethyl isothiocyanate	1	1
Phyllanthus amarus	1	1
Pine Cone	1	1
Piperine	1	1
Pistachio nut	1	1
Plantago	1	1
Pomegranate Peel	1	1
Prickly Pear Cactus	1	1
Prunella vulgaris	1	1
Purple Carrots	1	1
Quince	1	1
Radish	1	1
Raisins	1	1
Rice: Black	1	1
Rooibos	1	1
Rose Hips	1	1
Sarsaparilla	1	1
Saw Palmetto	1	1
Sesame Seeds	1	1
Shallot	1	1
Silver (nanoparticles)	1	1
Skullcap: Chinese	1	1
Soy	1	1
Spikenard	1	1
Syrian rue	1	1
Tabebuia	1	1
Tamarind	1	1
Tart Cherry	1	1
Terminalia chebula	1	1
Truffles	1	1
Turmerones	1	1
Tyrosol	1	1
Unsaponifiables	1	1
Vegetables: All	1	1
Vitamin E: alpha tocopherol	1	1
Wasabi	2	1
White Button Mushroom	1	1
White Clover	1	1
White Mulberry	1	1
Wild basil	1	1
Wormwood	1	1
Yellow Sweet Clover (Melilotus officinalis)	1	1
Zinc	1	1
beta-Carotene	1	1

[+]

A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. PMID: 15668484

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors

Additional Keywords : Antineoplastic Agents

[+]

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2013 Nov ;8(5):1542-8. Epub 2013 Aug 29. PMID: 24002213

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Article Publish Status : This is a free article. Click here to read the complete article.

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

The data support the strategy of flavonoid supplementation to mitigate post-exercise oxidative stress in endurance athletes.Nov 20, 2019

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Pubmed Data : Int J Sport Nutr Exerc Metab. 2019 Nov 21:1-8. Epub 2019 Nov 21. PMID: 31754080

Farrerol ameliorates TNBS-induced colonic inflammation.Jul 12, 2018

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Pubmed Data : Biomed Res Int. 2017 ;2017:3634915. Epub 2017 Nov 7. PMID: 29238715

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Colorectal Cancer

Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.Jan 31, 2019

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Pubmed Data : Cancer Lett. 2019 Feb 1 ;448:20-30. Epub 2019 Feb 1. PMID: 30716361

Article Published Date : Jan 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Colon Cancer

Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors

[+]

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID: 27468227

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2020 Jun 5 ;142:111483. Epub 2020 Jun 5. PMID: 32512025

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Pubmed Data : J Ethnopharmacol. 2013 Mar 7 ;146(1):300-10. Epub 2013 Jan 10. PMID: 23313393

Article Published Date : Mar 06, 2013

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 2008 Sep 18. [Epub ahead of print] PMID: 18802031

Article Published Date : Sep 18, 2008

Study Type : Animal Study

Additional Links

Substances : Ginseng (American)

Diseases : Colitis: Pseudomembranous, Ulcerative Colitis

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Tumor Suppressor Protein p53 Upregulation

[+]

Antarctic krill oil diet protects against lipopolysaccharide-induced oxidative stress, neuroinflammation and cognitive impairment.Nov 27, 2017

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Pubmed Data : Int J Mol Sci. 2017 Nov 28 ;18(12). Epub 2017 Nov 28. PMID: 29182579

Article Published Date : Nov 27, 2017

Study Type : Animal Study

Additional Links

Substances : Krill

Diseases : Alzheimer's Disease, Brain: Oxidative Stress, Brain Inflammation , Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents

[+]

Anthocyanin-rich fractions from red raspberries attenuate inflammation both in vitro and in vivo.Dec 31, 2013

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Pubmed Data : Foods. 2023 Apr 6 ;12(7). Epub 2023 Apr 6. PMID: 37048379

Article Published Date : Apr 05, 2023

Study Type : Animal Study

Additional Links

Substances : Garlic: Aged, Vitamin B12, Vitamin C, Vitamin D

Diseases : Cardiovascular Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vasoprotective

[+]

Anti-inflammatory effects of deuterium-depleted water plus Rosa damascena essential oil via cyclooxygenase-2 pathway.Jan 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Ethnopharmacol. 2008 Aug 13;118(3):387-95. Epub 2008 May 7. PMID: 18571350

Additional Keywords : Dose Response

[+]

Artesunate affords protection against aspirin-induced gastric injury.Mar 31, 2018

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Pubmed Data : Pharmacol Rep. 2018 Apr ;70(2):390-397. Epub 2017 Jun 15. PMID: 29397336

Article Published Date : Mar 31, 2018

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2022 Dec ;170:113468. Epub 2022 Oct 14. PMID: 36244460

Article Published Date : Nov 30, 2022

Study Type : Animal Study

Additional Links

Substances : Asiatic Acid

Diseases : Kidney Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Nrf2 activation, Renoprotective

[+]

Asiatic acid is a potent nutraceutical agent against the progression of Parkinson's disease.Mar 31, 2016

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Pubmed Data : Food Funct. 2016 Apr ;7(4):1999-2005. PMID: 26999333

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Pubmed Data : Brain Res. 2016 Dec 22. Epub 2016 Dec 22. PMID: 28017669

Article Published Date : Dec 21, 2016

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Brain Inflammation , Depression, Diabetic Complications

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Prophylactic Agents

[+]

Astaxanthin significantly suppressed the occurrence of esophageal cancer.Dec 31, 2018

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Pubmed Data : Mol Med Rep. 2016 Apr ;13(4):3289-96. Epub 2016 Feb 22. PMID: 26936538

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Arthritis, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Atractylodes macrocephala or Taraxacum herba extracts can be considered natural agents that can prevent inflammatory bowel disease relapse.Sep 14, 2017

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Pubmed Data : Toxins (Basel). 2021 Sep 16 ;13(9). Epub 2021 Sep 16. PMID: 34564665

Article Published Date : Sep 15, 2021

Study Type : Animal Study

Additional Links

Substances : Bee Venom

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831

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Pubmed Data : Reprod Sci. 2007 Apr;14(3):270-9. PMID: 17636241

Article Published Date : Apr 01, 2007

Study Type : Animal Study

Additional Links

Substances : Bee Propolis, Caffeic acid phenethyl ester

Diseases : Endometriosis

Pharmacological Actions : Antioxidants, Cyclooxygenase 2 Inhibitors

[+]

Camel milk attenuates rheumatoid arthritis in animals. Sep 19, 2017

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2023 Mar ;48(6):1597-1605. PMID: 37005848

Article Published Date : Feb 28, 2023

Study Type : Animal Study

Additional Links

Substances : Chrysin

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, Neuroprotective Agents

[+]

Chrysin has a protective effect against cyclophosphamide -induced hepatorenal toxicity.Oct 15, 2019

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Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct 16. Epub 2019 Oct 16. PMID: 31620822

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Pubmed Data : J Nutr. 2006 May;136(5):1150-5. PMID: 16614396

Article Published Date : May 01, 2006

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Polyphenols

Diseases : Tumors

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2018 03 ;38(3):1461-1466. PMID: 29491072

Article Published Date : Dec 31, 2017

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin, Rutin

Diseases : Human Papillomavirus (HPV), Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors

[+]

Crocetin supplementation in the MCA mice also showed protection against cervical cancer. Dec 31, 2014

Pubmed Data : Int Immunopharmacol. 2007 Mar;7(3):333-42. Epub 2006 Dec 18. PMID: 17276891

Article Published Date : Mar 01, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Colitis, Ulcerative Colitis

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Curcumin attenuated glucose intolerance and insulin resistance through its antioxidant and anti-inflammatory effects.Dec 19, 2015

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Pubmed Data : Chem Biol Interact. 2015 Dec 20. Epub 2015 Dec 20. PMID: 26713546

Article Published Date : Dec 19, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Inflammation, Insulin Resistance, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.Dec 31, 2016

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Pubmed Data : Mediators Inflamm. 2017 ;2017:6280925. Epub 2017 Jan 11. PMID: 28167853

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Pubmed Data : Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10. PMID: 19903839

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Pubmed Data : Int J Cancer. 2009 Nov 1 ;125(9):2187-97. PMID: 19623659

Article Published Date : Oct 31, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model. Oct 15, 2005

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Pubmed Data : Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID: 16243823

Dendrosomal curcumin has a chemoprotective effect on the breast cancer metastasis through suppression of NF-κB and its regulated gene products.Jul 04, 2015

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Pubmed Data : Eur J Pharmacol. 2015 Jul 5 ;758:188-96. Epub 2015 Apr 8. PMID: 25863259

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Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients.Dec 31, 2022

A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

Carbohydrate ingestion from bananas had positive influence in attenuating metabolic perturbation and inflammation following 75-km cycling.Dec 31, 2017

Consumption of dried apple peel powder was associated with improved joint function and improved serum antioxidant protection status.Oct 31, 2014

Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.Dec 31, 2011

Electroacupuncture may prevent ischemia-reperfusion-induced endothelial dysfunction via a COX-2 dependent mechanism.Dec 31, 2016

Electroacupuncture treatment alleviates central post-stroke pain.Dec 31, 2015

EPA supplementation significantly reduces Cox-2 enzyme expression in Barrett's esophagus.Apr 01, 2008

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritisFeb 29, 2016

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis. Jul 01, 2009

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.Feb 14, 2012

Rapid changes in histone deacetylases and inflammatory gene expression in expert meditatorsJan 31, 2014

Sesamin can relieve clinical symptoms and pathological changes that caused by inflammatory impairment in patients with rheumatoid arthritis.Aug 31, 2019

Spirulina has favorable effects on lipid profiles, immune variables and antioxidant capacity in healthy individuals.Jan 01, 2008

The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA.Dec 31, 2016

The data support the strategy of flavonoid supplementation to mitigate post-exercise oxidative stress in endurance athletes.Nov 20, 2019

These findings indicate that combination therapy of ω-3 fatty acids and nano-curcumin can be considered as a promising new approach in migraine prevention.Dec 31, 2018

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

Tocotrienols attenuate UV-induced inflammaging.Jun 01, 2018

Vitamin C attenuates aspirin-induced gastric damage. May 01, 2009

Alpha-bisobolol inhibits lipopolysaccharide-induced inflammation.Oct 01, 2011

Berberine alleviates myocardial ischemia-reperfusion injury.Nov 30, 2022

Betulinic acid exerts anti-inflammatory activity in human periodontal ligament cells stimulated with lipopolysaccharide or high glucose.May 08, 2022

Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.Nov 14, 2012

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Marine alga Ecklonia cava extract and dieckol attenuate prostaglandin E2 production in HaCaT keratinocytes exposed to airborne particulate matter.Jun 20, 2019

Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.Feb 13, 2017

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Oleocanthal inhibits catabolic and inflammatory mediators in LPS-activated human primary osteoarthritis chondrocytes.Dec 31, 2017

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.May 07, 2017

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.Oct 04, 2022

Anticancer investigation of fullerene C60 on DMBA induced breast cancer.Feb 14, 2022

Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer's disease.Jan 31, 2023

Farrerol ameliorates TNBS-induced colonic inflammation.Jul 12, 2018

Ginkgolide A ameliorates lipopolysaccharide-induced inflammatory responses.Apr 09, 2017

In vitro and in vivo assessment of the anti-inflammatory activity of olive leaf extract in rats.May 31, 2023

Macrophage-targeted berberine-loaded β-glucan nanoparticles enhance the treatment of ulcerative colitis.Dec 31, 2021

Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation.Sep 12, 2023

The potential of BEN815 as an anti-inflammatory, antiviral and antioxidant agent for the treatment of COVID-19.Oct 31, 2021

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney.Aug 14, 2020

The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study Mar 25, 2020

Therapeutic effect of melittin on a rat model of chronic prostatitis induced by complete freund's adjuvant.May 31, 2017

"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."Feb 15, 2011

18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.Dec 31, 2015

2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside may be a promising natural lead compound for treating early phases of colorectal cancer.Dec 31, 2016

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.Jan 31, 2019

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

5-hydroxytryptophan attenuates imiquimod-induced psoriasiform dermatitis.Jan 10, 2018

6-Gingerol abates benzo[a]pyrene-induced colonic injury.Apr 17, 2019

6-gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer. Jun 04, 2020

6-gingerol prevented DSS-induced chronic ulcerative colitis via anti-inflammatory and antioxidative mechanisms.Dec 31, 2017

6-Shogaol reduces progression of experimental endometriosis.Oct 31, 2018

A Burdock extract was able to reduce intestinal inflammation in an acute TNBS-induced experimental model of colitis in rats.Mar 06, 2013

A combination of ginger and peony root may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.Nov 29, 2015

A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer.Mar 26, 2019

A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss.Nov 30, 2017

A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients.Nov 03, 2016

Acacetin alleviates inflammation and matrix degradation in nucleus pulposus cells and ameliorates intervertebral disc degeneration.Dec 31, 2019

Acacetin attenuates neuroinflammation.Jun 30, 2012

Açaí demonstrated protective effects against AOM/DSS-induced colon carcinogenesis.Mar 14, 2017

Activities of Andrographis paniculata tablet on Cox-2 and prostaglandin expression of placental of Plasmodium berghei infection.Dec 31, 2020

Adlay bran ethanolic extract suppressed 1,2-dimethylhydrazine-indued preneoplastic lesions of the colon.Jul 13, 2010

Administration of chlorogenic acid alleviates spinal cord injury.Dec 31, 2017

Alleviative effects of pinostrobin against cadmium-induced renal toxicity.Dec 31, 2022

Allyl isothiocyanate ameliorates angiogenesis and inflammation in dextran sulfate sodium-induced acute colitis.Dec 31, 2013

Allylmethylsulfide (AMS), a volatile organosulfur derivative from garlic has radioprotective properties.Jun 01, 2009

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1204 Abstracts with Cyclooxygenase 2 Inhibitors Research