Cyclooxygenase 2 Inhibitors

Name	AC	CK
Curcumin	78	122
Flavonoids	66	112
Ginsenosides	26	40
Resveratrol	23	35
Berberine	17	33
Frankincense	11	33
Omega-3 Fatty Acids	8	28
Polyphenols	17	26
Sulforaphane	17	26
Melatonin	12	24
Cannabis	8	23
Phloretin	7	23
Oleuropein	7	22
Vitamin C	8	22
Fisetin	14	21
Ginkgo biloba	13	21
Thymoquinone	12	21
Rose	11	18
Spirulina	5	18
Turmeric	8	18
Piperine	3	17
Mulberry	12	16
Tanshinone IIA	11	16
Ginseng (Korean)	11	15
Quercetin	11	15
Chrysin	8	14
Myricetin	10	14
Astaxanthin	8	13
Cannabinoids	4	13
DHA (Docosahexaenoic Acid)	4	13
Pterostilbene	9	13
Rosmarinic acid	8	13
Seaweed: Brown	7	13
Wogonin	9	13
Anthocyanins	8	12
Apples	2	12
Grape	7	12
Hesperidin	7	12
Sesamin	2	12
Banana	2	11
EPA (Eicosapentaenoic Acid)	2	11
Fermented Foods and Beverages	9	11
Fucoxanthin	6	11
Pomegranate	7	11
Strawberry	2	11
Bee Venom	7	10
Dandelion	7	10
Diosmin	6	10
Dogwood	6	10
Eicosapentaenoic acid (EPA)	1	10
Formononetin	7	10
Geraniol	5	10
Gingerol	6	10
MSM (Methylsulfonylmethane)	1	10
Paeoniflorin	7	10
Reishi Mushroom	8	10
Tocotrienols	1	10
Alpha-Lipoic Acid	5	9
Betulinic acid	4	9
Citrus naringin	7	9
Ginger	5	9
Grape Seed Extract	5	9
Lotus	7	9
Lycopene	6	9
Mangiferin	7	9
Oleocanthal	4	9
Oligonol	5	9
Puerarin	6	9
Royal Jelly	6	9
Rutin	5	9
Vitamin D	4	9
Walnut	6	9
Zerumbone	6	9
Adlay	6	8
Cannabidiol	6	8
Carvacrol	5	8
Emodin	4	8
Lignans	4	8
Lion's Mane (Hericium Erinaceus)	4	8
Medicinal Mushrooms	6	8
Naringenin	6	8
Nobiletin	6	8
Stilbenes	5	8
Asiatic Acid	4	7
Astragaloside	3	7
Carbon 60	3	7
EGCG (Epigallocatechin gallate)	6	7
Ellagic Acid	5	7
Fucoidan	4	7
Hydroxytyrosol	4	7
Japanese cypress	4	7
Licorice	4	7
Noni	4	7
Palmitoylethanolamide	4	7
Patchouli	4	7
Perilla	4	7
Punicalagin	5	7
Raspberry	4	7
Andrographis	4	6
Antrodia camphorata	4	6
Apigenin	4	6
Beta-Caryophyllene	4	6
Black Tea	4	6
Blueberry	4	6
Catechin	5	6
Crocin	4	6
Garlic	4	6
Ginseng	3	6
Gotu Kola	4	6
Honeysuckle	5	6
Honokiol	4	6
Indole-3-Carbinol	3	6
Isoliquiritigenin	4	6
Luteolin	6	6
Olive	5	6
Olive leaf extract	3	6
Piceatannol	4	6
Salvia miltiorrhiza	3	6
Shikonin	3	6
Silibinin	4	6
Tetrahydrocurcumin	3	6
Arctigenin	3	5
Artesunate	3	5
Bromelain	5	5
Caffeic acid phenethyl ester	3	5
Carnosol	3	5
Chaga Mushroom (Inonotus obliquus)	4	5
Citrus Peel	3	5
Diosgenin	3	5
Elecampane	5	5
Eugenol	4	5
Gastrodin	3	5
Genipin	3	5
Green Tea	2	5
Guava	3	5
Isothiocyanates	4	5
Justicia gendarussa	3	5
Lupeol	3	5
Moringa oleifera	3	5
Nettle	3	5
Parthenolide	4	5
Piperlongumine	4	5
Probiotics	3	5
Red Clover	4	5
Sesamol	3	5
Tangeretin	4	5
Vitex negundo	3	5
Water: Deuterium Depleted	3	5
White Tea	3	5
Apple Polyphenols	2	4
Arginine	2	4
Ashwagandha	3	4
Beta-glucan	2	4
Bitter Melon	4	4
Brown Rice	2	4
Cardamonin	3	4
Chamomile	3	4
Chlorogenic Acid	3	4
Cordyceps sinensis	2	4
Crocetin	3	4
D-Limonene	2	4
Daidzein	3	4
Dates	2	4
Delta-tetrahydrocannabinol (THC)	3	4
Ferulic acid	3	4
Flaxseed	2	4
Garcinia kola	2	4
Lactobacillus fermentum	2	4
Lactobacillus plantarum	3	4
Lychee	2	4
Magnolia	2	4
Magnolol	2	4
Medium Chain Triglycerides	2	4
Nexrutine (Phellodendrom)	3	4
Nigella sativa (aka Black Seed)	4	4
P-Coumaric Acid	3	4
Paeonol	3	4
Palm Oil	2	4
Peony	3	4
Phenethyl isothiocyanate	3	4
Plantago	3	4
Psychedelics:All	3	4
Rice Bran	2	4
Saffron	3	4
Saikosaponin	3	4
Saturated fatty acids	2	4
Sea buckthorn	2	4
Sweet Potato: Purple	2	4
Thymol	2	4
Toona sinensis	3	4
Ursolic Acid	4	4
Vitamin E	2	4
Xanthohumol	3	4
18β-Glycyrrhetinic Acid	2	3
Aduki bean	2	3
Aloe Vera	3	3
Avocado	2	3
Bee Propolis	2	3
Bisdemethoxycurcumin	1	3
Bitter Orange	3	3
Black Currant	2	3
Capsaicin	3	3
Carnosic Acid	3	3
Celastrol	2	3
Chinese Skullcap	2	3
Chrysanthemum Indicum	3	3
Citrus Triterpenoids	1	3
Cordyceps Militaris	2	3
Eriodictyol	2	3
Gallic Acid	2	3
Genistein	3	3
Ginseng (American)	2	3
Honey	2	3
Hops	2	3
Isoflavones	2	3
Kaempferol	2	3
Kimchi	3	3
Maitake Mushroom	2	3
Mint	2	3
Mushrooms: All	2	3
Orange	2	3
Phellinus Linteus	2	3
Phlorotannins	3	3
Pine Bark Extract	2	3
Polyunsaturated Fatty Acids (PUFAs)	2	3
Poria cocos	3	3
Psilocybin	2	3
Red Sage	2	3
Rosemary	2	3
Safflower	2	3
Selenium	2	3
Tocotrienol: Gamma	2	3
Turmerones	2	3
Vinegar	2	3
acetyl-11-keto-beta-boswellic acid	2	3
5-HTP (5-Hydroxytryptophan)	1	2
6-Shogaol	1	2
ALA (Alpha-Linolenic Acid)	1	2
Acai	1	2
African Basil	1	2
Agaricus Blazei	1	2
Alpha Linolenic Acid	1	2
Angelica	2	2
Apocynin	1	2
Apple	1	2
Artemisia asiatica	1	2
Artemisinin	2	2
Arugula	2	2
Asparagus	2	2
Bai Zhu	1	2
Barley	1	2
Benzyl isothiocyanate	1	2
Bergamot	1	2
Biotin	1	2
Boswellia	1	2
Brazil nut	1	2
Burdock	1	2
Butterbur	2	2
Butterfly Pea	2	2
Camel Milk	1	2
Carnitine	1	2
Carrot	1	2
Chickpea	2	2
Chlorella (Algae)	2	2
Chokeberry	1	2
Chrysanthemum Morifolium	2	2
Citrus Oils	1	2
Cocoa	1	2
Coptis chinensis	1	2
Corn: Purple	1	2
Cranberry	1	2
Curry Tree	1	2
Cyanidin 3-glucoside	1	2
Damnacanthal	1	2
Delphinidin	1	2
Demethoxycurcumin	1	2
Echinacea	2	2
Evening Primrose Oil	1	2
Garcinia indica	1	2
Gardenia	1	2
Garlic: Aged	1	2
Geranium	1	2
Germanium	2	2
Ginseng (Siberian)	1	2
Gold (nanoparticles)	1	2
Goldenrod	1	2
Graviola	1	2
Guggul	2	2
Hawthorn	1	2
Hazelnut	2	2
Hemp Seed	1	2
Horseradish	2	2
Hu Zhang (Polygonum cuspidatum)	1	2
Hydrogen Water	1	2
Hydrogen: Molecular	1	2
Indigo Naturalis	1	2
Isoquercitrin	1	2
Jujube	2	2
Kaempferia parviflora	1	2
Kefir	1	2
Krill	1	2
Kudzu	1	2
L-Carnitine	1	2
Lactobacillus paracasei	1	2
Lactobacillus reuteri	2	2
Lactobacillus rhamnosus	1	2
Lavender	1	2
Ligustrazine	1	2
Loquat	1	2
Mangosteen	1	2
Manuka Honey	1	2
Mugwort	1	2
Myo-inositol	1	2
Nicotinamide adenine dinucleotide (NADH)	1	2
Noni leaf extract	1	2
Nutmeg	1	2
Oak	1	2
Olive Oil	2	2
Orange: Mandarin	2	2
Oregano	1	2
Panax Ginseng	1	2
Panax Notoginseng	2	2
Papaya	1	2
Paprika	1	2
Pau D'Arco	1	2
Pea	2	2
Pelargonium sidoides	1	2
Peppermint	1	2
Persimmon	2	2
Pine Needle	1	2
Pineapple	1	2
Plantago asiatica	1	2
Polypodium leucotomos	1	2
Pomegranate Seed	1	2
Potato	1	2
Raspberry ketone	1	2
Red Wine	1	2
Rosemaric Acid	1	2
Ruta Graveolens	1	2
Safranal	1	2
Schisandra	1	2
Shiitake Mushroom	1	2
Sinomenine	1	2
Skullcap: Chinese	2	2
Sour Cherry	1	2
Tannic Acid	1	2
Taurine	1	2
Tea	1	2
Theaflavins	2	2
Theanine	1	2
Thistle	1	2
Thuja	1	2
Tongkat Ali	1	2
Turmeric: Fermented	1	2
Urolithin A	1	2
Vanillin	2	2
Verbascoside	2	2
Vitamin B-3 (Niacin)	1	2
Vitamin B12	1	2
Watermelon	1	2
Wheat Germ	2	2
Xanthones	2	2
Yam	1	2
Yeast	1	2
Yoghurt	1	2
Zeaxanthin	1	2
Achillea fragrantissima	1	1
Agrimony	1	1
Almond	1	1
Amla Fruit	1	1
Amygdalin (laetrile)	1	1
Andrographolide	1	1
Apple Pectin	1	1
Avacado	1	1
Avenanthramides	1	1
Bacopa	1	1
Baicalein	1	1
Bamboo	1	1
Beet	1	1
Bifidobacterium Breve	1	1
Biochanin A	1	1
Black Pepper	1	1
Black Raspberry	1	1
Caffeic Acid	1	1
Carotenoids	1	1
Cashew	1	1
Celery	1	1
Celery seed	1	1
Cherry: All Varieties	1	1
Cinnamaldehyde	1	1
Cinnamon	1	1
Cissus quadrangularis	1	1
Citric Acid	1	1
Coenzyme Q10	1	1
Coumestrol	1	1
Cucurbitacin B	1	1
Cumin	1	1
Cyanidin	1	1
Deguelin	1	1
False Black Pepper	1	1
Feverfew	1	1
Fish Oil	1	1
Fruit Peel	1	1
Fruit: All	1	1
Gleditsia sinensis	1	1
Glycyrrhiza uralensis	1	1
Glycyrrhizin	1	1
Goji	1	1
Green Coffee Bean	1	1
Homeopathic Medicine: All	1	1
Huperzine	1	1
Hyaluronic Acid	1	1
Kahweol	1	1
Kale	1	1
Kava Kava	1	1
Lactobacillus rhamnosus GG	1	1
Lavender: Essential Oil	1	1
Litchi	1	1
Long Pepper	1	1
Loquat Leaves	1	1
Lutein	1	1
Macadamia	1	1
Mango	1	1
Maqui	1	1
Mastic gum	1	1
Modified Citrus Pectin	1	1
Mussel: Green-lipped (Perna canaliculus)	1	1
Nuts	1	1
Oats	1	1
Onion	1	1
Oranges	1	1
Organosulfur Compounds	1	1
Oridonin	1	1
Orthosiphon	1	1
Passion Flower	1	1
Phyllanthus amarus	1	1
Pine Cone	1	1
Pistachio nut	1	1
Pomegranate Peel	1	1
Prickly Pear Cactus	1	1
Prunella vulgaris	1	1
Purple Carrots	1	1
Quince	1	1
Radish	1	1
Raisins	1	1
Rice: Black	1	1
Rooibos	1	1
Rose Hips	1	1
Sage	1	1
Sarsaparilla	1	1
Saw Palmetto	1	1
Sesame Seeds	1	1
Shallot	1	1
Shitake Mushroom	1	1
Silver (nanoparticles)	1	1
Soy	1	1
Spikenard	1	1
Sumac	1	1
Syrian rue	1	1
Tabebuia	1	1
Tamarind	1	1
Tart Cherry	1	1
Terminalia chebula	1	1
Truffles	1	1
Tyrosol	1	1
Unsaponifiables	1	1
Vegetables: All	1	1
Vinpocetine	1	1
Vitamin E: alpha tocopherol	1	1
Wasabi	2	1
White Button Mushroom	1	1
White Clover	1	1
White Mulberry	1	1
Wild basil	1	1
Wormwood	1	1
Yellow Sweet Clover (Melilotus officinalis)	1	1
Zinc	1	1
beta-Carotene	1	1

[+]

A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. PMID: 15668484

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors

Additional Keywords : Antineoplastic Agents

[+]

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

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Pubmed Data : Mol Med Rep. 2013 Nov ;8(5):1542-8. Epub 2013 Aug 29. PMID: 24002213

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Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

The data support the strategy of flavonoid supplementation to mitigate post-exercise oxidative stress in endurance athletes.Nov 20, 2019

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Pubmed Data : Int J Sport Nutr Exerc Metab. 2019 Nov 21:1-8. Epub 2019 Nov 21. PMID: 31754080

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

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Bisdemethoxycurcumin ameliorates adjuvant-induced arthritis by suppressing inflammatory reactions and macrophage migration.Jan 04, 2024

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Pubmed Data : Chem Biol Interact. 2024 Jan 5 ;387:110822. Epub 2023 Dec 5. PMID: 38056805

Article Published Date : Jan 04, 2024

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bisdemethoxycurcumin

Diseases : Arthritis, Inflammation, Lipopolysaccharide-Induced Toxicity, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells.Jan 31, 2015

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Pubmed Data : Int J Mol Med. 2015 Feb ;35(2):383-90. Epub 2014 Dec 9. PMID: 25503577

Article Published Date : Jan 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Aging Skin

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 alpha downregulation

[+]

Farrerol ameliorates TNBS-induced colonic inflammation.Jul 12, 2018

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Pubmed Data : Biomed Res Int. 2017 ;2017:3634915. Epub 2017 Nov 7. PMID: 29238715

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Colorectal Cancer

Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.Jan 31, 2019

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Pubmed Data : Cancer Lett. 2019 Feb 1 ;448:20-30. Epub 2019 Feb 1. PMID: 30716361

Article Published Date : Jan 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Colon Cancer

Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors

[+]

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

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Pubmed Data : Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID: 27468227

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Pubmed Data : Food Chem Toxicol. 2020 Jun 5 ;142:111483. Epub 2020 Jun 5. PMID: 32512025

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Pubmed Data : J Ethnopharmacol. 2013 Mar 7 ;146(1):300-10. Epub 2013 Jan 10. PMID: 23313393

Article Published Date : Mar 06, 2013

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Article Published Date : Sep 12, 2019

Study Type : Animal Study

Additional Links

Substances : Hemp Seed

Diseases : Hypercholesterolemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hypolipidemic

[+]

Ameliorative effects of loganin on arthritis in chondrocytes.Feb 07, 2021

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Pubmed Data : Foods. 2023 Apr 6 ;12(7). Epub 2023 Apr 6. PMID: 37048379

Article Published Date : Apr 05, 2023

Study Type : Animal Study

Additional Links

Substances : Garlic: Aged, Vitamin B12, Vitamin C, Vitamin D

Diseases : Cardiovascular Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vasoprotective

[+]

Anti-inflammatory effects of deuterium-depleted water plus Rosa damascena essential oil via cyclooxygenase-2 pathway.Jan 31, 2020

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Pubmed Data : J Ethnopharmacol. 2008 Aug 13;118(3):387-95. Epub 2008 May 7. PMID: 18571350

Additional Keywords : Dose Response

[+]

Artesunate affords protection against aspirin-induced gastric injury.Mar 31, 2018

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Pubmed Data : Pharmacol Rep. 2018 Apr ;70(2):390-397. Epub 2017 Jun 15. PMID: 29397336

Article Published Date : Mar 31, 2018

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Pubmed Data : Food Chem Toxicol. 2022 Dec ;170:113468. Epub 2022 Oct 14. PMID: 36244460

Article Published Date : Nov 30, 2022

Study Type : Animal Study

Additional Links

Substances : Asiatic Acid

Diseases : Kidney Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Nrf2 activation, Renoprotective

[+]

Asiatic acid is a potent nutraceutical agent against the progression of Parkinson's disease.Mar 31, 2016

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Pubmed Data : Food Funct. 2016 Apr ;7(4):1999-2005. PMID: 26999333

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Pubmed Data : Brain Res. 2016 Dec 22. Epub 2016 Dec 22. PMID: 28017669

Article Published Date : Dec 21, 2016

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Brain Inflammation , Depression, Diabetic Complications

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Prophylactic Agents

[+]

Astaxanthin significantly suppressed the occurrence of esophageal cancer.Dec 31, 2018

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Pubmed Data : Mol Med Rep. 2016 Apr ;13(4):3289-96. Epub 2016 Feb 22. PMID: 26936538

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Arthritis, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Atractylodes macrocephala or Taraxacum herba extracts can be considered natural agents that can prevent inflammatory bowel disease relapse.Sep 14, 2017

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Pubmed Data : Toxins (Basel). 2021 Sep 16 ;13(9). Epub 2021 Sep 16. PMID: 34564665

Article Published Date : Sep 15, 2021

Study Type : Animal Study

Additional Links

Substances : Bee Venom

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

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Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831

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Cloudy apple juice potentiates hepatoprotection during experimental liver injury.Aug 20, 2019

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Pubmed Data : Int J Biol Macromol. 2019 Aug 21 ;140:1006-1017. Epub 2019 Aug 21. PMID: 31445146

Article Published Date : Aug 20, 2019

Study Type : Animal Study

Additional Links

Substances : Apple

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective

[+]

Cocoa may merit further clinical investigation as a chemopreventive agent that helps prevent colitis-associated cancer. Dec 31, 2014

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Pubmed Data : BMC Complement Altern Med. 2018 Jan 19 ;18(1):20. Epub 2018 Jan 19. PMID: 29351747

Article Published Date : Jan 18, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Coptis chinensis, Pelargonium sidoides

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury.Nov 30, 2022

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View the Evidence: 1266 Abstracts with Cyclooxygenase 2 Inhibitors Research

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Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients.Dec 31, 2022

A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

Carbohydrate ingestion from bananas had positive influence in attenuating metabolic perturbation and inflammation following 75-km cycling.Dec 31, 2017

Consumption of dried apple peel powder was associated with improved joint function and improved serum antioxidant protection status.Oct 31, 2014

Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.Dec 31, 2011

Electroacupuncture may prevent ischemia-reperfusion-induced endothelial dysfunction via a COX-2 dependent mechanism.Dec 31, 2016

Electroacupuncture treatment alleviates central post-stroke pain.Dec 31, 2015

EPA supplementation significantly reduces Cox-2 enzyme expression in Barrett's esophagus.Apr 01, 2008

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritisFeb 29, 2016

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis. Jul 01, 2009

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.Feb 14, 2012

Rapid changes in histone deacetylases and inflammatory gene expression in expert meditatorsJan 31, 2014

Sesamin can relieve clinical symptoms and pathological changes that caused by inflammatory impairment in patients with rheumatoid arthritis.Aug 31, 2019

Spirulina has favorable effects on lipid profiles, immune variables and antioxidant capacity in healthy individuals.Jan 01, 2008

The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA.Dec 31, 2016

The data support the strategy of flavonoid supplementation to mitigate post-exercise oxidative stress in endurance athletes.Nov 20, 2019

These findings indicate that combination therapy of ω-3 fatty acids and nano-curcumin can be considered as a promising new approach in migraine prevention.Dec 31, 2018

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

Tocotrienols attenuate UV-induced inflammaging.Jun 01, 2018

Vitamin C attenuates aspirin-induced gastric damage. May 01, 2009

Alpha-bisobolol inhibits lipopolysaccharide-induced inflammation.Oct 01, 2011

Berberine alleviates myocardial ischemia-reperfusion injury.Nov 30, 2022

Betulinic acid exerts anti-inflammatory activity in human periodontal ligament cells stimulated with lipopolysaccharide or high glucose.May 08, 2022

Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.Nov 14, 2012

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Irradiation with 590-nm yellow light-emitting diode light attenuates oxidative stress and modulates UVB-induced change of dermal fibroblasts.May 31, 2022

Marine alga Ecklonia cava extract and dieckol attenuate prostaglandin E2 production in HaCaT keratinocytes exposed to airborne particulate matter.Jun 20, 2019

Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.Feb 13, 2017

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Oleocanthal inhibits catabolic and inflammatory mediators in LPS-activated human primary osteoarthritis chondrocytes.Dec 31, 2017

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.May 07, 2017

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.Oct 04, 2022

Anticancer investigation of fullerene C60 on DMBA induced breast cancer.Feb 14, 2022

Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer's disease.Jan 31, 2023

Bisdemethoxycurcumin ameliorates adjuvant-induced arthritis by suppressing inflammatory reactions and macrophage migration.Jan 04, 2024

Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells.Jan 31, 2015

Farrerol ameliorates TNBS-induced colonic inflammation.Jul 12, 2018

Ginkgolide A ameliorates lipopolysaccharide-induced inflammatory responses.Apr 09, 2017

In vitro and in vivo assessment of the anti-inflammatory activity of olive leaf extract in rats.May 31, 2023

Limonin inhibits IL-1 β-induced inflammation and catabolism in chondrocytes and ameliorates osteoarthritis.Dec 31, 2020

Macrophage-targeted berberine-loaded β-glucan nanoparticles enhance the treatment of ulcerative colitis.Dec 31, 2021

Myricetin suppresses traumatic brain injury-induced inflammatory response.Dec 19, 2023

Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation.Sep 12, 2023

The potential of BEN815 as an anti-inflammatory, antiviral and antioxidant agent for the treatment of COVID-19.Oct 31, 2021

Tieguanyin Oolong tea extracts alleviate behavioral abnormalities by modulating neuroinflammation in APP/PS1 mouse model of Alzheimer's disease.Dec 28, 2021

Vitamin D can relieve ulcerative colitis by inhibiting ferroptosis both in mice and in cells.Nov 19, 2023

Withaferin A alleviates inflammation in animal models of arthritis by inhibiting the NF-κB pathway and cytokine release.Jul 31, 2024

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney.Aug 14, 2020

The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study Mar 25, 2020

Therapeutic effect of melittin on a rat model of chronic prostatitis induced by complete freund's adjuvant.May 31, 2017

"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."Feb 15, 2011

18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.Dec 31, 2015

2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside may be a promising natural lead compound for treating early phases of colorectal cancer.Dec 31, 2016

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.Jan 31, 2019

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

5-hydroxytryptophan attenuates imiquimod-induced psoriasiform dermatitis.Jan 10, 2018

6-Gingerol abates benzo[a]pyrene-induced colonic injury.Apr 17, 2019

6-gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer. Jun 04, 2020

6-gingerol prevented DSS-induced chronic ulcerative colitis via anti-inflammatory and antioxidative mechanisms.Dec 31, 2017

6-Shogaol reduces progression of experimental endometriosis.Oct 31, 2018

A Burdock extract was able to reduce intestinal inflammation in an acute TNBS-induced experimental model of colitis in rats.Mar 06, 2013

A combination of ginger and peony root may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.Nov 29, 2015

A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer.Mar 26, 2019

A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss.Nov 30, 2017

A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients.Nov 03, 2016

Acacetin alleviates inflammation and matrix degradation in nucleus pulposus cells and ameliorates intervertebral disc degeneration.Dec 31, 2019

Cyclooxygenase 2 Inhibitors

View the Evidence:
1266 Abstracts with Cyclooxygenase 2 Inhibitors Research