Cyclooxygenase 2 Inhibitors

Name	AC	CK
Curcumin	79	123
Flavonoids	72	120
Ginsenosides	26	40
Resveratrol	23	35
Berberine	17	33
Frankincense	11	33
Omega-3 Fatty Acids	8	28
Polyphenols	17	26
Sulforaphane	17	26
Melatonin	12	24
Cannabis	8	23
Oleuropein	8	23
Phloretin	7	23
Vitamin C	8	22
Fisetin	14	21
Ginkgo biloba	13	21
Thymoquinone	12	21
Rose	12	20
Turmeric	9	20
Quercetin	13	18
Spirulina	5	18
Piperine	3	17
Tanshinone IIA	12	17
Mulberry	12	16
Ginseng (Korean)	11	15
Wogonin	10	15
Cannabinoids	5	14
Chrysin	8	14
Ginger	8	14
Myricetin	10	14
Astaxanthin	8	13
DHA (Docosahexaenoic Acid)	4	13
Pterostilbene	9	13
Rosmarinic acid	8	13
Seaweed: Brown	7	13
Anthocyanins	8	12
Apples	2	12
Grape	7	12
Hesperidin	7	12
Sesamin	2	12
Banana	2	11
EPA (Eicosapentaenoic Acid)	2	11
Fermented Foods and Beverages	9	11
Fucoxanthin	6	11
Pomegranate	7	11
Reishi Mushroom	9	11
Strawberry	2	11
Bee Venom	7	10
Cannabidiol	7	10
Dandelion	7	10
Diosmin	6	10
Dogwood	6	10
Eicosapentaenoic acid (EPA)	1	10
Formononetin	7	10
Geraniol	5	10
Gingerol	6	10
Leonurine	6	10
MSM (Methylsulfonylmethane)	1	10
Medicinal Mushrooms	7	10
Paeoniflorin	7	10
Tocotrienols	1	10
Alpha-Lipoic Acid	5	9
Betulinic acid	4	9
Citrus naringin	7	9
Grape Seed Extract	5	9
Lotus	7	9
Lycopene	6	9
Mangiferin	7	9
Oleocanthal	4	9
Oligonol	5	9
Puerarin	6	9
Royal Jelly	6	9
Rutin	5	9
Vitamin D	4	9
Walnut	6	9
Zerumbone	6	9
Adlay	6	8
Ashwagandha	5	8
Carvacrol	5	8
Emodin	4	8
Lignans	4	8
Lion's Mane (Hericium Erinaceus)	4	8
Luteolin	7	8
Naringenin	6	8
Nobiletin	6	8
Salvia miltiorrhiza	4	8
Stilbenes	5	8
Asiatic Acid	4	7
Astragaloside	3	7
Carbon 60	3	7
EGCG (Epigallocatechin gallate)	6	7
Ellagic Acid	5	7
Fucoidan	4	7
Green Tea	3	7
Hydroxytyrosol	4	7
Japanese cypress	4	7
Licorice	4	7
Noni	4	7
Olive leaf extract	4	7
Palmitoylethanolamide	4	7
Patchouli	4	7
Perilla	4	7
Punicalagin	5	7
Raspberry	4	7
Syringic Acid	4	7
Vanillic Acid	5	7
Andrographis	4	6
Antrodia camphorata	4	6
Apigenin	4	6
Beta-Caryophyllene	4	6
Black Tea	4	6
Blueberry	4	6
Catechin	5	6
Crocin	4	6
Garlic	4	6
Ginseng	3	6
Gotu Kola	4	6
Honeysuckle	5	6
Honokiol	4	6
Indole-3-Carbinol	3	6
Isoliquiritigenin	4	6
Lactobacillus salivarius	3	6
Olive	5	6
Piceatannol	4	6
Shikonin	3	6
Silibinin	4	6
Tetrahydrocurcumin	3	6
Arctigenin	3	5
Artesunate	3	5
Bromelain	5	5
Caffeic acid phenethyl ester	3	5
Carnosol	3	5
Chaga Mushroom (Inonotus obliquus)	4	5
Citrus Peel	3	5
Diosgenin	3	5
Elecampane	5	5
Eugenol	4	5
Gastrodin	3	5
Genipin	3	5
Guava	3	5
Honey	3	5
Isothiocyanates	4	5
Justicia gendarussa	3	5
Lupeol	3	5
Moringa oleifera	3	5
Mushrooms: All	3	5
Nettle	3	5
Parthenolide	4	5
Piperlongumine	4	5
Probiotics	3	5
Red Clover	4	5
Sesamol	3	5
Tangeretin	4	5
Vitex negundo	3	5
Water: Deuterium Depleted	3	5
White Tea	3	5
Apple Polyphenols	2	4
Arginine	2	4
Beta-glucan	2	4
Bitter Melon	4	4
Brown Rice	2	4
Cardamonin	3	4
Chamomile	3	4
Chlorogenic Acid	3	4
Cordyceps sinensis	2	4
Crocetin	3	4
D-Limonene	2	4
Daidzein	3	4
Dates	2	4
Delta-tetrahydrocannabinol (THC)	3	4
Ferulic acid	3	4
Flaxseed	2	4
Gallic Acid	3	4
Garcinia kola	2	4
Jujube	3	4
Lactobacillus fermentum	2	4
Lactobacillus plantarum	3	4
Lychee	2	4
Magnolia	2	4
Magnolol	2	4
Medium Chain Triglycerides	2	4
Nexrutine (Phellodendrom)	3	4
Nigella sativa (aka Black Seed)	4	4
Orange	3	4
P-Coumaric Acid	3	4
Paeonol	3	4
Palm Oil	2	4
Peony	3	4
Phenethyl isothiocyanate	3	4
Plantago	3	4
Psychedelics:All	3	4
Rice Bran	2	4
Saffron	3	4
Saikosaponin	3	4
Saturated fatty acids	2	4
Sea buckthorn	2	4
Sweet Potato: Purple	2	4
Thymol	2	4
Toona sinensis	3	4
Ursolic Acid	4	4
Vitamin E	2	4
Xanthohumol	3	4
18β-Glycyrrhetinic Acid	2	3
Aduki bean	2	3
Aloe Vera	3	3
Avocado	2	3
Bee Propolis	2	3
Bisdemethoxycurcumin	1	3
Bitter Orange	3	3
Black Currant	2	3
Capsaicin	3	3
Carnosic Acid	3	3
Celastrol	2	3
Chinese Skullcap	2	3
Chrysanthemum Indicum	3	3
Citrus Triterpenoids	1	3
Cordyceps Militaris	2	3
Cucurbitacin B	3	3
Eriodictyol	2	3
Garlic: Aged	2	3
Genistein	3	3
Ginseng (American)	2	3
Hops	2	3
Isoflavones	2	3
Kaempferol	2	3
Kimchi	3	3
Maitake Mushroom	2	3
Mint	2	3
Nicotinamide Mononucleotide	2	3
Phellinus Linteus	2	3
Phlorotannins	3	3
Pine Bark Extract	2	3
Polyunsaturated Fatty Acids (PUFAs)	2	3
Poria cocos	3	3
Psilocybin	2	3
Red Sage	2	3
Rosemary	2	3
Safflower	2	3
Scopoletin	2	3
Selenium	2	3
Tea: Oolong	1	3
Tocotrienol: Gamma	2	3
Turmerones	2	3
Vinegar	2	3
acetyl-11-keto-beta-boswellic acid	2	3
5-HTP (5-Hydroxytryptophan)	1	2
6-Shogaol	1	2
ALA (Alpha-Linolenic Acid)	1	2
Acai	1	2
African Basil	1	2
Agaricus Blazei	1	2
Alpha Linolenic Acid	1	2
Andrographolide	2	2
Angelica	2	2
Apocynin	1	2
Apple	1	2
Artemisia asiatica	1	2
Artemisinin	2	2
Arugula	2	2
Asparagus	2	2
Bai Zhu	1	2
Baicalein	2	2
Barley	1	2
Benzyl isothiocyanate	1	2
Bergamot	1	2
Biotin	1	2
Boswellia	1	2
Brazil nut	1	2
Burdock	1	2
Butterbur	2	2
Butterfly Pea	2	2
Camel Milk	1	2
Carnitine	1	2
Carrot	1	2
Chickpea	2	2
Chicoric Acid	1	2
Chlorella (Algae)	2	2
Chokeberry	1	2
Chrysanthemum Morifolium	2	2
Citrus Oils	1	2
Cocoa	1	2
Coptis chinensis	1	2
Corn: Purple	1	2
Cranberry	1	2
Curry Tree	1	2
Cyanidin 3-glucoside	1	2
Damnacanthal	1	2
Delphinidin	1	2
Demethoxycurcumin	1	2
Echinacea	2	2
Evening Primrose Oil	1	2
Fiber	1	2
Garcinia indica	1	2
Gardenia	1	2
Geranium	1	2
Germanium	2	2
Ginseng (Siberian)	1	2
Gold (nanoparticles)	1	2
Goldenrod	1	2
Graviola	1	2
Guggul	2	2
Hawthorn	1	2
Hazelnut	2	2
Hemp Seed	1	2
Horse Chestnut	1	2
Horseradish	2	2
Hu Zhang (Polygonum cuspidatum)	1	2
Hydrogen Water	1	2
Hydrogen: Molecular	1	2
Indigo Naturalis	1	2
Isoquercitrin	1	2
Kaempferia parviflora	1	2
Kefir	1	2
Krill	1	2
Kudzu	1	2
L-Carnitine	1	2
Lactobacillus paracasei	1	2
Lactobacillus reuteri	2	2
Lactobacillus rhamnosus	1	2
Lavender	1	2
Lavender: Essential Oil	2	2
Ligustrazine	1	2
Loquat	1	2
Mangosteen	1	2
Manuka Honey	1	2
Mugwort	1	2
Myo-inositol	1	2
Myrtenol	1	2
Nicotinamide adenine dinucleotide (NADH)	1	2
Noni leaf extract	1	2
Nutmeg	1	2
Oak	1	2
Olive Oil	2	2
Orange: Mandarin	2	2
Oregano	1	2
Panax Ginseng	1	2
Panax Notoginseng	2	2
Papaya	1	2
Paprika	1	2
Pau D'Arco	1	2
Pea	2	2
Pelargonium sidoides	1	2
Peppermint	1	2
Persimmon	2	2
Pine Needle	1	2
Pineapple	1	2
Plantago asiatica	1	2
Polypodium leucotomos	1	2
Pomegranate Seed	1	2
Potato	1	2
Raspberry ketone	1	2
Red Wine	1	2
Rosemaric Acid	1	2
Ruta Graveolens	1	2
Safranal	1	2
Schisandra	1	2
Shiitake Mushroom	1	2
Sinomenine	1	2
Skullcap: Chinese	2	2
Sour Cherry	1	2
Tannic Acid	1	2
Taurine	1	2
Tea	1	2
Theaflavins	2	2
Theanine	1	2
Thistle	1	2
Thuja	1	2
Tongkat Ali	1	2
Turmeric: Fermented	1	2
Urolithin A	1	2
Vanillin	2	2
Verbascoside	2	2
Vitamin B-3 (Niacin)	1	2
Vitamin B12	1	2
Watermelon	1	2
Wheat Germ	2	2
Xanthones	2	2
Yam	1	2
Yeast	1	2
Yoghurt	1	2
Zeaxanthin	1	2
Achillea fragrantissima	1	1
Agrimony	1	1
Almond	1	1
Amla Fruit	1	1
Amygdalin (laetrile)	1	1
Apple Pectin	1	1
Avacado	1	1
Avenanthramides	1	1
Bacopa	1	1
Bamboo	1	1
Beet	1	1
Bifidobacterium Breve	1	1
Biochanin A	1	1
Black Pepper	1	1
Black Raspberry	1	1
Caffeic Acid	1	1
Cannabigerol	1	1
Carotenoids	1	1
Cashew	1	1
Celery	1	1
Celery seed	1	1
Cherry: All Varieties	1	1
Cinnamaldehyde	1	1
Cinnamon	1	1
Cissus quadrangularis	1	1
Citric Acid	1	1
Coenzyme Q10	1	1
Common bean	1	1
Coumestrol	1	1
Cumin	1	1
Cyanidin	1	1
Deguelin	1	1
False Black Pepper	1	1
Feverfew	1	1
Fish Oil	1	1
Fruit Peel	1	1
Fruit: All	1	1
Gleditsia sinensis	1	1
Glycyrrhiza uralensis	1	1
Glycyrrhizin	1	1
Goji	1	1
Green Coffee Bean	1	1
Homeopathic Medicine: All	1	1
Huperzine	1	1
Hyaluronic Acid	1	1
Kahweol	1	1
Kale	1	1
Kava Kava	1	1
Lactobacillus rhamnosus GG	1	1
Lactococcus lactis	1	1
Litchi	1	1
Long Pepper	1	1
Loquat Leaves	1	1
Lutein	1	1
Macadamia	1	1
Mango	1	1
Maqui	1	1
Mastic gum	1	1
Modified Citrus Pectin	1	1
Mululuza	1	1
Mussel: Green-lipped (Perna canaliculus)	1	1
Nasturtium	1	1
Nuts	1	1
Oats	1	1
Onion	1	1
Oranges	1	1
Organosulfur Compounds	1	1
Oridonin	1	1
Orthosiphon	1	1
Passion Flower	1	1
Phyllanthus amarus	1	1
Pine Cone	1	1
Pistachio nut	1	1
Pomegranate Peel	1	1
Prickly Pear Cactus	1	1
Prunella vulgaris	1	1
Purple Carrots	1	1
Quince	1	1
Radish	1	1
Raisins	1	1
Rice: Black	1	1
Rooibos	1	1
Rose Hips	1	1
Sage	1	1
Sarsaparilla	1	1
Saw Palmetto	1	1
Sesame Seeds	1	1
Shallot	1	1
Shitake Mushroom	1	1
Silver (nanoparticles)	1	1
Soy	1	1
Spikenard	1	1
Sumac	1	1
Syrian rue	1	1
Tabebuia	1	1
Tamarind	1	1
Tart Cherry	1	1
Terminalia chebula	1	1
Truffles	1	1
Tyrosol	1	1
Unsaponifiables	1	1
Vegetables: All	1	1
Vinpocetine	1	1
Vitamin E: alpha tocopherol	1	1
Wasabi	2	1
White Button Mushroom	1	1
White Clover	1	1
White Mulberry	1	1
Wild basil	1	1
Wormwood	1	1
Yellow Sweet Clover (Melilotus officinalis)	1	1
Zinc	1	1
beta-Carotene	1	1

[+]

Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients.Dec 31, 2022

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Pubmed Data : Cell Immunol. 2023 ;391-392:104752. Epub 2023 Jul 22. PMID: 37536000

Article Published Date : Dec 31, 2022

Study Type : Human In Vitro, Human Study

Additional Links

Substances : Piperine

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. PMID: 15668484

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors

Additional Keywords : Antineoplastic Agents

[+]

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Med Rep. 2013 Nov ;8(5):1542-8. Epub 2013 Aug 29. PMID: 24002213

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Psychoneuroendocrinology. 2014 Feb ;40:96-107. Epub 2013 Nov 15. PMID: 24485481

Click here to read the entire abstract

Pubmed Data : Int J Sport Nutr Exerc Metab. 2019 Nov 21:1-8. Epub 2019 Nov 21. PMID: 31754080

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Bisdemethoxycurcumin ameliorates adjuvant-induced arthritis by suppressing inflammatory reactions and macrophage migration.Jan 04, 2024

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Pubmed Data : Chem Biol Interact. 2024 Jan 5 ;387:110822. Epub 2023 Dec 5. PMID: 38056805

Article Published Date : Jan 04, 2024

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Bisdemethoxycurcumin

Diseases : Arthritis, Inflammation, Lipopolysaccharide-Induced Toxicity, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells.Jan 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2015 Feb ;35(2):383-90. Epub 2014 Dec 9. PMID: 25503577

Article Published Date : Jan 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Aging Skin

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 alpha downregulation

[+]

Farrerol ameliorates TNBS-induced colonic inflammation.Jul 12, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Biomed Res Int. 2017 ;2017:3634915. Epub 2017 Nov 7. PMID: 29238715

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Colorectal Cancer

Pharmacological Actions : Anticarcinogenic Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.Jan 31, 2019

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Pubmed Data : Cancer Lett. 2019 Feb 1 ;448:20-30. Epub 2019 Feb 1. PMID: 30716361

Article Published Date : Jan 31, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Diseases : Colon Cancer

Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors

[+]

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID: 27468227

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Pubmed Data : Food Chem Toxicol. 2020 Jun 5 ;142:111483. Epub 2020 Jun 5. PMID: 32512025

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Pubmed Data : J Ethnopharmacol. 2013 Mar 7 ;146(1):300-10. Epub 2013 Jan 10. PMID: 23313393

Article Published Date : Mar 06, 2013

Study Type : Animal Study

Additional Links

Substances : Burdock

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Article Published Date : Sep 12, 2019

Study Type : Animal Study

Additional Links

Substances : Hemp Seed

Diseases : Hypercholesterolemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Hypolipidemic

[+]

Ameliorative effects of loganin on arthritis in chondrocytes.Feb 07, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Antiosteoarthritic effect of morroniside in chondrocyte inflammation and destabilization of medial meniscus-induced mouse model.Mar 14, 2021

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Pubmed Data : J Ethnopharmacol. 2008 Aug 13;118(3):387-95. Epub 2008 May 7. PMID: 18571350

Additional Keywords : Dose Response

[+]

Artesunate affords protection against aspirin-induced gastric injury.Mar 31, 2018

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Pubmed Data : Pharmacol Rep. 2018 Apr ;70(2):390-397. Epub 2017 Jun 15. PMID: 29397336

Article Published Date : Mar 31, 2018

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Pubmed Data : Food Chem Toxicol. 2018 Apr ;114:227-236. Epub 2018 Feb 20. PMID: 29471006

Article Published Date : Mar 31, 2018

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Chemotherapy-Induced Toxicity: Cisplatin, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

[+]

Bee venom alleviated edema and pain in monosodium urate crystals-induced gouty arthritis.Sep 15, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Toxins (Basel). 2021 Sep 16 ;13(9). Epub 2021 Sep 16. PMID: 34564665

Article Published Date : Sep 15, 2021

Study Type : Animal Study

Additional Links

Substances : Bee Venom

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.Sep 28, 2006

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Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831

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Pubmed Data : J Med Food. 2017 Apr ;20(4):367-375. PMID: 28406732

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Aduki bean

Diseases : Colitis, High Fat Diet, Inflammation, Lipopolysaccharide-Induced Toxicity, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Black ginseng-enriched Chong-Myung-Tang extracts improve spatial learning behavior.Mar 31, 2017

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Cloudy apple juice potentiates hepatoprotection during experimental liver injury.Aug 20, 2019

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Pubmed Data : Int J Biol Macromol. 2019 Aug 21 ;140:1006-1017. Epub 2019 Aug 21. PMID: 31445146

Article Published Date : Aug 20, 2019

Study Type : Animal Study

Additional Links

Substances : Apple

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective

[+]

Cocoa may merit further clinical investigation as a chemopreventive agent that helps prevent colitis-associated cancer. Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chem Biol Interact. 2015 Dec 20. Epub 2015 Dec 20. PMID: 26713546

Article Published Date : Dec 19, 2015

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Inflammation, Insulin Resistance, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects.Dec 31, 2016

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Pubmed Data : Mediators Inflamm. 2017 ;2017:6280925. Epub 2017 Jan 11. PMID: 28167853

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Pubmed Data : Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10. PMID: 19903839

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Pubmed Data : Int J Cancer. 2009 Nov 1 ;125(9):2187-97. PMID: 19623659

Article Published Date : Oct 31, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

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Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model. Oct 15, 2005

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Pubmed Data : Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID: 16243823

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Dietary leonurine hydrochloride supplementation attenuates lipopolysaccharide challenge-induced intestinal inflammation and barrier dysfunction.Apr 02, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Anim Sci. 2019 Apr 3 ;97(4):1679-1692. PMID: 30789669

Article Published Date : Apr 02, 2019

Study Type : Animal Study

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Substances : Leonurine

Diseases : Gastrointestinal Inflammation, Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Chinese Traditional Medicine

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Dietary oleocanthal supplementation prevents inflammation and oxidative stress in collagen-induced arthritis.Apr 22, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Asia Pac J Clin Nutr. 2010;19(1):142-50. PMID: 20132809

Article Published Date : Jan 01, 2010

Study Type : Animal Study

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Substances : Resveratrol, Stilbenes

Diseases : Inflammation, Ulcerative Colitis

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, P38 Mitogen-Activated Protein Kinase Modulator, Prostaglandin E Synthase-1 (PGES-1) Down-Regulation

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Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Cosmet Laser Ther. 2011 Oct ;13(5):237-42. PMID: 21774661

Article Published Date : Sep 30, 2011

Study Type : Animal Study

Additional Links

Diseases : Burns, Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Vascular Endothelial Growth Factor Inhibitors

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Effect of p-cymene and rosmarinic acid on gastric ulcer healing - Involvement of multiple endogenous curative mechanisms.Feb 15, 2021

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Pubmed Data : Phytomedicine. 2021 Feb 16:153497. Epub 2021 Feb 16. PMID: 33745762

Article Published Date : Feb 15, 2021

Study Type : Animal Study

Additional Links

Substances : Rosmarinic acid

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Interleukin-1 beta downregulation, Transforming growth factor beta (TGF-β) upregulation

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Effect of ultra-Micronized-palmitoylethanolamide and acetyl-l-carnitine on experimental model of inflammatory pain.Feb 16, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Inflamm Res. 2021 ;14:859-868. Epub 2021 Mar 12. PMID: 33737826

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine.Apr 14, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Int Immunopharmacol. 2017 Feb 14 ;45:135-147. Epub 2017 Feb 14. PMID: 28213268

Article Published Date : Feb 13, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Fisetin suppresses the inflammatory response and oxidative stress in bronchial epithelial cells.Apr 27, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063

Article Published Date : Jan 31, 2011

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor

Problem Substances : Aspirin

Adverse Pharmacological Actions : Ulcerogenic

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Fucoxanthin could be a novel adjuvant for preventing exacerbations associated with skin inflammation as well as protecting skin against UV radiation.Oct 09, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mar Drugs. 2018 Oct 10 ;16(10). Epub 2018 Oct 10. PMID: 30308980

Article Published Date : Oct 09, 2018

Study Type : Animal Study

Additional Links

Substances : Fucoxanthin

Diseases : Erythema, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Photoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Fucoxanthin may have therapeutic potential as a treatment for patients with inflammatory diseases.Sep 28, 2015

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Pubmed Data : J Biochem Mol Toxicol. 2015 Sep 29. Epub 2015 Sep 29. PMID: 26418808

Article Published Date : Sep 28, 2015

Study Type : Animal Study

Additional Links

Substances : Fucoxanthin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

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Fucoxanthin prevents lipopolysaccharide-induced depressive-like behavior in mice.Dec 14, 2018

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Pubmed Data : Metab Brain Dis. 2018 Dec 15. Epub 2018 Dec 15. PMID: 30554399

Article Published Date : Dec 14, 2018

Study Type : Animal Study

Additional Links

Substances : Fucoxanthin

Diseases : Depression, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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View the Evidence: 1326 Abstracts with Cyclooxygenase 2 Inhibitors Research

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Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients.Dec 31, 2022

A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.Jan 01, 2005

A formulation containing Frankincense and Turmeric extracts demonstrated a greater improvement in the treatment of OA than celecoxib.Oct 31, 2013

Carbohydrate ingestion from bananas had positive influence in attenuating metabolic perturbation and inflammation following 75-km cycling.Dec 31, 2017

Consumption of dried apple peel powder was associated with improved joint function and improved serum antioxidant protection status.Oct 31, 2014

Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.Dec 31, 2011

Electroacupuncture may prevent ischemia-reperfusion-induced endothelial dysfunction via a COX-2 dependent mechanism.Dec 31, 2016

Electroacupuncture treatment alleviates central post-stroke pain.Dec 31, 2015

EPA supplementation significantly reduces Cox-2 enzyme expression in Barrett's esophagus.Apr 01, 2008

Influence of superpulsed laser therapy on healing processes following tooth extraction.Jul 31, 2011

Methylsulfonylmethane and boswellic acids versus glucosamine sulfate in the treatment of knee arthritisFeb 29, 2016

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis. Jul 01, 2009

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

Pre-exercise infrared laser irradiation with dose of 1.0 J enhances skeletal muscle performance and decreases post-exercise skeletal muscle damage and inflammation.Dec 31, 2010

Pycnogenol may be of value in treatment of MSU crystal-induced arthritis through its anti-inflammatory and anti-nitrosative activities.Feb 14, 2012

Rapid changes in histone deacetylases and inflammatory gene expression in expert meditatorsJan 31, 2014

Sesamin can relieve clinical symptoms and pathological changes that caused by inflammatory impairment in patients with rheumatoid arthritis.Aug 31, 2019

Spirulina has favorable effects on lipid profiles, immune variables and antioxidant capacity in healthy individuals.Jan 01, 2008

The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA.Dec 31, 2016

The data support the strategy of flavonoid supplementation to mitigate post-exercise oxidative stress in endurance athletes.Nov 20, 2019

The effect of low-level diode laser on COX-2 gene expression in chronic periodontitis patients.Aug 31, 2017

These findings indicate that combination therapy of ω-3 fatty acids and nano-curcumin can be considered as a promising new approach in migraine prevention.Dec 31, 2018

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

Tocotrienols attenuate UV-induced inflammaging.Jun 01, 2018

Vitamin C attenuates aspirin-induced gastric damage. May 01, 2009

Alpha-bisobolol inhibits lipopolysaccharide-induced inflammation.Oct 01, 2011

Berberine alleviates myocardial ischemia-reperfusion injury.Nov 30, 2022

Betulinic acid exerts anti-inflammatory activity in human periodontal ligament cells stimulated with lipopolysaccharide or high glucose.May 08, 2022

Cannabidiolic acid an active component in the cannabis plant offers potential therapeutic modality in the abrogation of cancer cell migration.Nov 14, 2012

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Irradiation with 590-nm yellow light-emitting diode light attenuates oxidative stress and modulates UVB-induced change of dermal fibroblasts.May 31, 2022

Low-power laser irradiation suppresses inflammatory response of human adipose-derived stem cells.Dec 31, 2012

Marine alga Ecklonia cava extract and dieckol attenuate prostaglandin E2 production in HaCaT keratinocytes exposed to airborne particulate matter.Jun 20, 2019

Melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.Feb 13, 2017

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Oleocanthal inhibits catabolic and inflammatory mediators in LPS-activated human primary osteoarthritis chondrocytes.Dec 31, 2017

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.May 07, 2017

Sulforaphane combats colon cancer in vitro by inhibiting COX-2 and prostaglandin E1 synthase and exhibiting anti-angiogenic, anti-proliferative, and anti-metastatic properties.Jan 01, 2018

Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.Oct 04, 2022

Anticancer investigation of fullerene C60 on DMBA induced breast cancer.Feb 14, 2022

Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer's disease.Jan 31, 2023

Bisdemethoxycurcumin ameliorates adjuvant-induced arthritis by suppressing inflammatory reactions and macrophage migration.Jan 04, 2024

Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells.Jan 31, 2015

Farrerol ameliorates TNBS-induced colonic inflammation.Jul 12, 2018

Ginkgolide A ameliorates lipopolysaccharide-induced inflammatory responses.Apr 09, 2017

In vitro and in vivo assessment of the anti-inflammatory activity of olive leaf extract in rats.May 31, 2023

Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis.Apr 30, 2019

Lactobacillus salivarius REN inhibits rat oral cancer induced by 4-nitroquioline 1-oxide.Jun 30, 2013

Limonin inhibits IL-1 β-induced inflammation and catabolism in chondrocytes and ameliorates osteoarthritis.Dec 31, 2020

Macrophage-targeted berberine-loaded β-glucan nanoparticles enhance the treatment of ulcerative colitis.Dec 31, 2021

Myricetin suppresses traumatic brain injury-induced inflammatory response.Dec 19, 2023

Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation.Sep 12, 2023

The potential of BEN815 as an anti-inflammatory, antiviral and antioxidant agent for the treatment of COVID-19.Oct 31, 2021

Tieguanyin Oolong tea extracts alleviate behavioral abnormalities by modulating neuroinflammation in APP/PS1 mouse model of Alzheimer's disease.Dec 28, 2021

Vitamin D can relieve ulcerative colitis by inhibiting ferroptosis both in mice and in cells.Nov 19, 2023

Withaferin A alleviates inflammation in animal models of arthritis by inhibiting the NF-κB pathway and cytokine release.Jul 31, 2024

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney.Aug 14, 2020

The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study Mar 25, 2020

Therapeutic effect of melittin on a rat model of chronic prostatitis induced by complete freund's adjuvant.May 31, 2017

"Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats."Feb 15, 2011

(-)-myrtenol has gastro-cytoprotective and ulcer healing properties.Jul 04, 2019

18β-Glycyrrhetinic acid significantly attenuated H. pylori-infected gastritis in gerbils.Dec 31, 2015

2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside may be a promising natural lead compound for treating early phases of colorectal cancer.Dec 31, 2016

3,3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2.Jan 31, 2019

5-FU and thymoquinone combination therapy resulted in a more significant reduction on AOM-induced colorectal tumors.Dec 31, 2015

5-hydroxytryptophan attenuates imiquimod-induced psoriasiform dermatitis.Jan 10, 2018

6-Gingerol abates benzo[a]pyrene-induced colonic injury.Apr 17, 2019

6-gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer. Jun 04, 2020

6-gingerol prevented DSS-induced chronic ulcerative colitis via anti-inflammatory and antioxidative mechanisms.Dec 31, 2017

Cyclooxygenase 2 Inhibitors

View the Evidence:
1326 Abstracts with Cyclooxygenase 2 Inhibitors Research