Epidermal growth factor receptor EGFR inhibitor

Name	AC	CK
Curcumin	14	16
Cherry: All Varieties	1	10
Cherry: Bing	1	10
Honokiol	4	4
Omega-3 Fatty Acids	2	4
EGCG (Epigallocatechin gallate)	2	3
Polyphenols	2	3
Berberine	1	2
Cannabidiol	1	2
Cucurbitacin B	1	2
Flaxseed	1	2
Fucoidan	1	2
Ginsenosides	1	2
Graviola	1	2
Homeopathic Medicine: All	1	2
Luteolin	1	2
Noni	1	2
Noni leaf extract	1	2
Plantago	1	2
Quercetin	1	2
Resveratrol	2	2
Saccharomyces Boulardii	1	2
Sulforaphane	1	2
Anandamide	1	1
Andrographis	1	1
Arctigenin	1	1
Avocado	1	1
Berries: All	1	1
Beta-Elemene	1	1
Betulinic acid	1	1
Bifidobacterium Breve	1	1
Catechin	1	1
Cinnamon	1	1
Cranberry	1	1
Flavan-3-ols	1	1
Garlic	1	1
Genistein	1	1
Gingerol	1	1
Grape Seed Extract	1	1
Hydroxytyrosol	1	1
Isoliquiritigenin	1	1
Kaempferol	1	1
Lactobacillus reuteri	1	1
Lauric acid	1	1
Litchi	1	1
Lithospermum erythrorhizon	1	1
Lupeol	1	1
Myricetin	1	1
Parthenolide	1	1
Proanthocyanidins	1	1
Probiotics	1	1
Shikonin	1	1
Silibinin	1	1

[+]

Curcumol exerts antitumor effect via inhibiting EGFR-Akt-Mcl-1 signaling. Mar 01, 2023

Click here to read the entire abstract

Pubmed Data : Am J Chin Med. 2023 Mar 2:1-20. Epub 2023 Mar 2. PMID: 36869017

Article Published Date : Mar 01, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumol

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

[+]

Berberine induced senescence of human glioblastoma cells.Jan 31, 2015

Click here to read the entire abstract

Pubmed Data : Mol Cancer Ther. 2015 Feb ;14(2):355-63. Epub 2014 Dec 12. PMID: 25504754

Article Published Date : Jan 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Glioblastoma

Pharmacological Actions : Anti-Tumor, Apoptotic, Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor

[+]

CBD can be used as a novel therapeutic option to inhibit growth and metastasis of highly aggressive breast cancer subtypes including TNBC.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : Mol Oncol. 2015 Apr ;9(4):906-19. Epub 2015 Jan 19. PMID: 25660577

Article Published Date : Mar 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabidiol

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

[+]

Cucurbitacin B administration inhibited MDA-MB-231 orthotopic tumors by 55%, and 4T-1 tumors by 40%.Apr 14, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2014 Apr 15 ;5(7):1812-28. PMID: 24729020

Article Published Date : Apr 14, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed, Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Dose Response

[+]

Curcumin holds promise as an adjuvant to broaden the spectrum of gefitinib therapy to improve the efficacy of gefitinib among the NSCLC patients with different EGFR status.Dec 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2011 ;6(8):e23756. Epub 2011 Aug 17. PMID: 21858220

Article Published Date : Dec 31, 2010

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Chemotherapeutic Synergy: Gefitinib

[+]

Curcumin inhibits amyloid-petpide induced changes associated with the progression of Alzheimer's disease. Dec 01, 2004

Click here to read the entire abstract

Pubmed Data : J Neurochem. 2004 Dec;91(5):1199-210. PMID: 15569263

Article Published Date : Dec 01, 2004

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Alzheimer's Disease

Pharmacological Actions : Enzyme Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor, Neuroprotective Agents

[+]

EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2.May 31, 2014

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2014 Jun ;35(6):5593-8. Epub 2014 Feb 21. PMID: 24557544

Article Published Date : May 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells.Dec 31, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Cell Int. 2019 ;19:43. Epub 2019 Feb 28. PMID: 30858760

Article Published Date : Dec 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Thyroid Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Flaxseed oil reduces the growth of human breast tumors (MCF-7) at high levels of circulating estrogen.Oct 01, 2010

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2010 Oct;54(10):1414-21. PMID: 20425756

Article Published Date : Oct 01, 2010

Study Type : Animal Study

Additional Links

Substances : Flaxseed, Omega-3 Fatty Acids

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063

Article Published Date : Jan 31, 2011

Study Type : Animal Study

Additional Links

Substances : Fucoidan

Diseases : Aspirin-Induced Toxicity , Gastric Ulcer

Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor

Problem Substances : Aspirin

Adverse Pharmacological Actions : Ulcerogenic

[+]

Graviola selectively suppresses human breast cancer cells. Jan 01, 2011

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2011 ;63(5):795-801. Epub 2011 Jun 22. PMID: 21767082

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Graviola

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor, Oncogene Suppressor

Additional Keywords : Plant Extracts

[+]

Luteolin may be a potential candidate for NSCLC therapy, especially for treatment of patients with acquired erlotinib-resistant NSCLC.May 31, 2014

Click here to read the entire abstract

Pubmed Data : Br J Pharmacol. 2014 Jun ;171(11):2842-53. PMID: 24471765

Article Published Date : May 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Luteolin

Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Chemotherapeutic Synergy: Erlotinib

[+]

Morinda citrifolia leaf was more effective than the erlotinib in suppressing lung adenocarcinoma in mice. Jan 13, 2016

Click here to read the entire abstract

Pubmed Data : Food Funct. 2016 Jan 14. Epub 2016 Jan 14. PMID: 26765787

Article Published Date : Jan 13, 2016

Study Type : Animal Study

Additional Links

Substances : Noni, Noni leaf extract

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor, Immunomodulatory

Additional Keywords : Dose Response, Superiority of Natural Substances versus Drugs

[+]

Omega-3 polyunsaturated fatty acids has a preventive effect against atrial fibrillation in a canine model of pericarditis.Apr 01, 2010

Click here to read the entire abstract

Pubmed Data : Heart Rhythm. 2010 Apr;7(4):520-8. Epub 2009 Dec 28. PMID: 20156610

Article Published Date : Apr 01, 2010

Study Type : Animal Study

Additional Links

Substances : Omega-3 Fatty Acids

Diseases : Atrial Fibrillation, Pericarditis

Pharmacological Actions : Cardiovascular Agents, Epidermal growth factor receptor (EGFR) inhibitor, JAM3 gene down-regulation , Myosin heavy chain alpha (MHCalpha) reducer, Protein Kinase Inhibitors

[+]

Plantago major suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase.Sep 30, 2012

Click here to read the entire abstract

Pubmed Data : Mol Med Rep. 2012 Oct ;6(4):843-7. Epub 2012 Jul 4. PMID: 22767187

Article Published Date : Sep 30, 2012

Study Type : Animal Study

Additional Links

Substances : Plantago

Diseases : Preneoplastic Conditions

Pharmacological Actions : Chemopreventive, Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Plant Extracts

[+]

Quercetin was effective in preventing prostate cancer progression by inhibiting the EGFR signaling pathway and by regulating cell adhesion molecules.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Food Funct. 2014 Oct ;5(10):2632-45. Epub 2014 Aug 28. PMID: 25164625

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Polyphenols, Quercetin

Diseases : Prostate Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Epidermal growth factor receptor (EGFR) inhibitor, MicroRNA modulator

[+]

Saccharomyces boulardii may have a preventive role in intestinal and colon cancer. Sep 01, 2009

Click here to read the entire abstract

Pubmed Data : Gastroenterology. 2009 Sep;137(3):914-23. Epub 2009 May 29. PMID: 19482027

Article Published Date : Sep 01, 2009

Study Type : Animal Study

Additional Links

Substances : Saccharomyces Boulardii

Diseases : Colon Cancer, Intestinal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biomed Sci. 2015 ;22:38. Epub 2015 Jun 3. PMID: 26036303

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antiproliferative , Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

The overall result validated a positive effect of Condurango 30C in ameliorating lung cancer.Aug 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pharmacopuncture. 2013 Sep ;16(3):11-22. PMID: 25780671

Article Published Date : Aug 31, 2013

Study Type : Animal Study

Additional Links

Substances : Homeopathic Medicine: All

Diseases : Lung Cancer

Pharmacological Actions : Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

Problem Substances : Benzo(a)pyrene

[+]

10-gingerol showed selective cytotoxicity against malignant T4-2 breast cancer cells, and could revert the malignant phenotype.Jan 22, 2017

Click here to read the entire abstract

Pubmed Data : J Cell Biochem. 2017 Jan 23. Epub 2017 Jan 23. PMID: 28112417

Article Published Date : Jan 22, 2017

Study Type : In Vitro Study

Additional Links

Substances : Gingerol

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Selective Cytotoxicity

[+]

Anandamide possessed potent anti-proliferative and cytotoxic effects on metastatic prostatic cancer cells.Jun 14, 2003

Click here to read the entire abstract

Pubmed Data : Prostate. 2003 Jun 15 ;56(1):1-12. PMID: 12746841

Article Published Date : Jun 14, 2003

Study Type : In Vitro Study

Additional Links

Substances : Anandamide

Diseases : Prostate Cancer, Prostate Cancer: Metastatic

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Andrographis contains a compound which may induce cancer cell death through epidermal factor receptor and transferrin receptor modulation.Apr 01, 2010

Click here to read the entire abstract

Pubmed Data : Br J Pharmacol. 2010 Apr;159(7):1497-510. Epub 2010 Feb 19. PMID: 20233216

Article Published Date : Apr 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Andrographis

Diseases : Skin Cancer: Squamous Cell

Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor

[+]

Anti-cancer effects of bifidobacterium species in colon cancer cells and a mouse model of carcinogenesis. Dec 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2020 ;15(5):e0232930. Epub 2020 May 13. PMID: 32401801

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bifidobacterium Breve, Lactobacillus reuteri, Probiotics

Diseases : Colon Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway.Apr 30, 2017

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2017 May ;39(5):1010428317698359. PMID: 28459363

Article Published Date : Apr 30, 2017

Study Type : In Vitro Study

Additional Links

Substances : Arctigenin

Diseases : Gallbladder Cancer

Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

[+]

Beta-Elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells.Sep 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Oncol. 2016 Oct ;49(4):1427-36. Epub 2016 Jul 21. PMID: 27498706

Article Published Date : Sep 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Beta-Elemene

Diseases : Glioblastoma Multiforme

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Chemotherapeutic Synergy: Gefitinib

[+]

Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells.Jul 24, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Phytomedicine. 2023 Jul 25 ;116:154860. Epub 2023 May 3. PMID: 37201366

Article Published Date : Jul 24, 2023

Study Type : In Vitro Study

Additional Links

Substances : Caffeic acid phenethyl ester

Diseases : Prostate Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

[+]

Constituents of avocado fruits inhibit human oral cancer cell proliferation. Jun 10, 2011

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2011 Jun 10 ;409(3):465-9. Epub 2011 May 8. PMID: 21596018

Article Published Date : Jun 10, 2011

Study Type : In Vitro Study

Additional Links

Substances : Avocado

Diseases : Oral Cancer

Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

[+]

Cranberry flavonols and PACs possess cytotoxic properties against ovarian cancer cells. Apr 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Oncol. 2015 May ;46(5):1924-34. Epub 2015 Mar 17. PMID: 25776829

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cranberry, Flavan-3-ols

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer, Cytotoxic, Epidermal growth factor receptor (EGFR) inhibitor, P21 Activation

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

[+]

Curcumin and betulinic acid downregulate epidermal growth factor receptor in bladder cancer cells.May 01, 2010

Click here to read the entire abstract

Pubmed Data : Mol Cancer Res. 2010 May;8(5):739-50. Epub 2010 Apr 20. PMID: 20407012

Article Published Date : May 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Betulinic acid, Curcumin

Diseases : Bladder Cancer

Pharmacological Actions : Antineoplastic Agents, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Curcumin and genistein may positively modulate EGF and therefore playing a therapeutic role in periodontal disease. Dec 01, 2004

Click here to read the entire abstract

Pubmed Data : J Periodontal Res. 2004 Dec;39(6):380-7. PMID: 15491342

Article Published Date : Dec 01, 2004

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Genistein

Diseases : Periodontal Diseases

Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor

[+]

Curcumin exhibits anticarcinogenic and anti-inflammatory properties.Dec 01, 1997

Click here to read the entire abstract

Pubmed Data : Arterioscler Thromb Vasc Biol. 1997 Dec;17(12):3406-13. PMID: 9437186

Article Published Date : Dec 01, 1997

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cancers: All, Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Curcumin has anti-pancreatic and lung cancer activity.Nov 01, 2006

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2006 Nov-Dec;26(6B):4423-30. PMID: 17201164

Article Published Date : Nov 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Lung Cancer, Pancreatic Cancer

Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Curcumin has therapeutic potential in prostate cancer.Jan 01, 2000

Click here to read the entire abstract

Pubmed Data : Mol Urol. 2000;4(1):1-6. PMID: 10851300

Article Published Date : Jan 01, 2000

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Prostate Cancer

Pharmacological Actions : Antineoplastic Agents, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Curcumin induces apoptosis of triple-negative breast cancer cells.Sep 25, 2012

Click here to read the entire abstract

Pubmed Data : Mol Med Report. 2012 Sep 26. Epub 2012 Sep 26. PMID: 23023821

Article Published Date : Sep 25, 2012

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : apoptosis, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Curcumin inhibits epidermal growth factor receptor activity in human epidermoid cancer cells.Dec 30, 1994

Click here to read the entire abstract

Pubmed Data : Biochim Biophys Acta. 1994 Dec 30;1224(3):597-600. PMID: 7803521

Article Published Date : Dec 30, 1994

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Skin Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

[+]

Curcumin inhibits human colon cancer cell growth.Jan 12, 2006

Click here to read the entire abstract

Pubmed Data : Oncogene. 2006 Jan 12;25(2):278-87. PMID: 16170359

Article Published Date : Jan 12, 2006

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Colon Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

[+]

Curcumin inhibits ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation associated with tumor cell growth.Aug 01, 1995

Click here to read the entire abstract

Pubmed Data : Carcinogenesis. 1995 Aug;16(8):1741-5. PMID: 7634398

Article Published Date : Aug 01, 1995

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Tumors

Pharmacological Actions : Anti-Tumor, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

[+]

Curcumin is able to inhibit directly the enzymatic activity of the EGFR intracellular domain.May 10, 2015

Click here to read the entire abstract

Pubmed Data : Biomacromolecules. 2015 May 11 ;16(5):1634-42. Epub 2015 Apr 24. PMID: 25893361

Article Published Date : May 10, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Squamous cell carcinoma

Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor

[+]

Curcumin may provide an ideal therapy to down-regulate epidermal growth factor receptor activity.Oct 31, 2012

Click here to read the entire abstract

Pubmed Data : J Mol Recognit. 2012 Nov ;25(11):623-9. PMID: 23108622

Article Published Date : Oct 31, 2012

Study Type : Review

Additional Links

Substances : Curcumin

Diseases : Cancers: All

Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor

[+]

Curcumin suppresses transcription factor Egr-1.Feb 15, 2000

Click here to read the entire abstract

Pubmed Data : Thromb Res. 2000 Feb 15;97(4):179-89. PMID: 10674404

Article Published Date : Feb 15, 2000

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor

[+]

EGCG exhibits anti-cancer activity against tamoxifen-resistant breast cancer lines.Apr 01, 2011

Click here to read the entire abstract

Pubmed Data : Biosci Rep. 2011 Apr ;31(2):99-108. PMID: 20446926

Article Published Date : Apr 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Catechin

Diseases : Breast Cancer, Cancer Metastasis, Cancers: Drug Resistant

Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Drug: Tamoxifen, Tamoxifen Resistance

[+]

Essential oil of Cinnamon exhibits significant anticancer activity against head and neck squamous cell carcinoma cells in vitro.Oct 31, 2015

Click here to read the entire abstract

Pubmed Data : J BUON. 2015 Nov-Dec;20(6):1518-25. PMID: 26854449

Article Published Date : Oct 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cinnamon

Diseases : Head and Neck Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Essential Oils

[+]

Garlic phytocompounds could regulate EGFR expression in colorectal cancer cells.Mar 26, 2017

Click here to read the entire abstract

Pubmed Data : Interdiscip Sci. 2017 Mar 27. Epub 2017 Mar 27. PMID: 28349439

Article Published Date : Mar 26, 2017

Study Type : In Vitro Study

Additional Links

Substances : Garlic

Diseases : Colorectal Cancer

Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : COLORECTAL CANCER, Epidermal growth factor receptor (EGFR) inhibitor, Garlic

[+]

Grape seed proanthocyanidins, honokiol and EGCG appear to be promising bioactive phytochemicals for the management of head and neck cancer.Nov 23, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2016 Nov 24 ;21(12). Epub 2016 Nov 24. PMID: 27886147

Article Published Date : Nov 23, 2016

Study Type : Review

Additional Links

Substances : EGCG (Epigallocatechin gallate), Grape Seed Extract, Honokiol, Proanthocyanidins

Diseases : Head and Neck Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Honokiol eliminates glioma/glioblastoma stem cell-like cells and inhibits tumor progression.Dec 25, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancers (Basel). 2018 Dec 26 ;11(1). Epub 2018 Dec 26. PMID: 30587839

Article Published Date : Dec 25, 2018

Study Type : In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Glioblastoma, Glioma

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Cancer Stem Cells

[+]

Honokiol inhibits growth and the progression of cancers of different organs.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Adv Exp Med Biol. 2016 ;928:245-265. PMID: 27671820

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Bladder Cancer, Breast Cancer, Gastric Cancer, Head and Neck Cancer, Lung Cancer, Melanoma, Neuroblastoma, Prostate Cancer, Skin Cancer: Non-Melanoma

Pharmacological Actions : Antiproliferative , Chemopreventive, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Honokiol is a promising candidate to suppress the development and even progression of lung tumors driven by EGFR deregulation.Jul 20, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2016 Jul 21. Epub 2016 Jul 21. PMID: 27458163

Article Published Date : Jul 20, 2016

Study Type : In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Lung Cancer, Lung Cancer: Prevention

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive, Chemosensitizer, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Chemotherapeutic Synergy: Erlotinib, Superiority of Natural Substances versus Drugs

[+]

Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy.Oct 09, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2017 Oct 10 ;8(47):83207-83224. Epub 2017 Aug 24. PMID: 29137335

Article Published Date : Oct 09, 2017

Study Type : In Vitro Study

Additional Links

Substances : Hydroxytyrosol

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.May 06, 2008

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Pubmed Data : J Natl Cancer Inst. 2008 May 7 ;100(9):672-9. Epub 2008 Apr 29. PMID: 18445819

Article Published Date : May 06, 2008

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer, Cancer Stem Cells, Cancers: Drug Resistant

Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor

Anti Therapeutic Actions : Chemotherapy

Problem Substances : Chemotherapy

[+]

Isoliquiritigenin suppresses NSCLC cell growth by directly targeting wild type or mutant EGFR.Dec 25, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Biol Chem. 2014 Dec 26 ;289(52):35839-48. Epub 2014 Nov 3. PMID: 25368326

Article Published Date : Dec 25, 2014

Study Type : In Vitro Study

Additional Links

Substances : Isoliquiritigenin

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Kaempferol may be a safe inhibitor against malignant pancreatic cancers.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(5):e0155264. Epub 2016 May 13. PMID: 27175782

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Kaempferol

Diseases : Pancreatic Cancer, Pancreatic Cancer: Metastatic

Pharmacological Actions : Anti-metastatic, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Dose Response

[+]

Lauric acid induce cell death in colon cancer cells mediated by the epidermal growth factor receptor downregulation.Apr 02, 2019

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Pubmed Data : Hum Exp Toxicol. 2019 Apr 3:960327119839185. Epub 2019 Apr 3. PMID: 30942101

Article Published Date : Apr 02, 2019

Study Type : In Vitro Study

Additional Links

Substances : Lauric acid

Diseases : Colon Cancer

Pharmacological Actions : Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Litchi seed extract suppressed EGFR signalling and inhibited NSCLC cell growth.Jan 04, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2017 Jan 5 ;17(1):16. Epub 2017 Jan 5. PMID: 28056952

Article Published Date : Jan 04, 2017

Study Type : In Vitro Study

Additional Links

Substances : Litchi

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Plant Extracts

[+]

Lupeol may act as a potent inhibitor of the EGFR signalling in oral squamous cell carcinoma.May 31, 2016

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Pubmed Data : Mol Cell Biochem. 2016 Jun ;417(1-2):97-110. Epub 2016 May 20. PMID: 27206736

Article Published Date : May 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Lupeol

Diseases : Oral Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Magnolol and honokiol inhibited the function and expression of BCRP with mechanism exploration.Dec 05, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2021 Dec 6 ;26(23). Epub 2021 Dec 6. PMID: 34885972

Article Published Date : Dec 05, 2021

Study Type : In Vitro Study

Additional Links

Substances : Honokiol, Magnolol

Diseases : Breast Cancer

Pharmacological Actions : Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor, Multidrug Resistance Gene Modulators

[+]

Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.Aug 31, 2007

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Carcinogenesis. 2007 Sep ;28(9):1918-27. Epub 2007 Aug 11. PMID: 17693661

Article Published Date : Aug 31, 2007

Study Type : In Vitro Study

Additional Links

Substances : Myricetin

Diseases : Cancers: All, Preneoplastic Conditions

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor

[+]

Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells.Nov 30, 2013

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Pubmed Data : Int J Oncol. 2013 Dec ;43(6):1895-900. Epub 2013 Oct 14. PMID: 24126683

Article Published Date : Nov 30, 2013

Study Type : In Vitro Study

Additional Links

Substances : Parthenolide

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Pharmacological Actions : Antioxidants, Enzyme Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor, NF-kappaB Inhibitor

[+]

Quercetin-loaded liposomes effectively induced apoptosis and decreased the epidermal growth factor receptor expression in colorectal cancer cells.Apr 30, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Med Sci. 2023 May ;48(3):321-328. PMID: 37791331

Article Published Date : Apr 30, 2023

Study Type : In Vitro Study

Additional Links

Substances : Quercetin

Diseases : Colorectal Cancer

Pharmacological Actions : Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

[+]

Resveratrol inhibits EGF-induced invasion of human lung cancer cells. Apr 01, 2010

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Pubmed Data : Zhongguo Fei Ai Za Zhi. 2010 Apr;13(4):287-91. PMID: 20677551

Article Published Date : Apr 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Cancer Metastasis, Lung Cancer

Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Stilbenes

[+]

Resveratrol may have value as a potential adjunctive treatment for late-stage hormone refractory prostate cancer.Nov 15, 2010

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Pubmed Data : Hum Mol Genet. 2010 Nov 15;19(22):4319-29. Epub 2010 Aug 20. PMID: 20729295

Article Published Date : Nov 15, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Prostate Cancer

Pharmacological Actions : Anti-Androgen, Antiproliferative , Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Drug Synergy, Stilbenes

[+]

Silibinin prevents the EGFR signaling pathway and may be used as an effective drug for the inhibition of metastasis of human breast cancer.Nov 01, 2011

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2011 Nov ;31(11):3767-73. PMID: 22110198

Article Published Date : Nov 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Silibinin

Diseases : Breast Cancer, Breast Cancer: Metastatic, Cancer Metastasis

Pharmacological Actions : Antioxidants, Epidermal growth factor receptor (EGFR) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor

[+]

The combination of erlotinib with shikonin or its derivatives might be a potential strategy to overcome drug resistance to erlotinib.Feb 15, 2015

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2015 Feb 16. Epub 2015 Feb 16. PMID: 25688715

Article Published Date : Feb 15, 2015

Study Type : In Vitro Study

Additional Links

Substances : Lithospermum erythrorhizon, Shikonin

Diseases : Glioblastoma Multiforme

Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Chemotherapeutic Synergy: Erlotinib, Drug Resistance

[+]

Therapeutic potential of curcumin and its nanoformulations for treating oral cancer.Jun 19, 2023

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Methodol. 2023 Jun 20 ;13(3):29-45. Epub 2023 Jun 20. PMID: 37456978

Article Published Date : Jun 19, 2023

Study Type : Review

Additional Links

Substances : Curcumin

Diseases : Oral Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Epidermal growth factor receptor (EGFR) inhibitor, NF-kappaB Inhibitor

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View the Evidence: 65 Abstracts with Epidermal growth factor receptor (EGFR) inhibitor Research

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Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans.Feb 28, 2013

Curcumol exerts antitumor effect via inhibiting EGFR-Akt-Mcl-1 signaling. Mar 01, 2023

Berberine induced senescence of human glioblastoma cells.Jan 31, 2015

CBD can be used as a novel therapeutic option to inhibit growth and metastasis of highly aggressive breast cancer subtypes including TNBC.Mar 31, 2015

Cucurbitacin B administration inhibited MDA-MB-231 orthotopic tumors by 55%, and 4T-1 tumors by 40%.Apr 14, 2014

Curcumin holds promise as an adjuvant to broaden the spectrum of gefitinib therapy to improve the efficacy of gefitinib among the NSCLC patients with different EGFR status.Dec 31, 2010

Curcumin inhibits amyloid-petpide induced changes associated with the progression of Alzheimer's disease. Dec 01, 2004

EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2.May 31, 2014

Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells.Dec 31, 2018

Flaxseed oil reduces the growth of human breast tumors (MCF-7) at high levels of circulating estrogen.Oct 01, 2010

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Graviola selectively suppresses human breast cancer cells. Jan 01, 2011

Luteolin may be a potential candidate for NSCLC therapy, especially for treatment of patients with acquired erlotinib-resistant NSCLC.May 31, 2014

Morinda citrifolia leaf was more effective than the erlotinib in suppressing lung adenocarcinoma in mice. Jan 13, 2016

Omega-3 polyunsaturated fatty acids has a preventive effect against atrial fibrillation in a canine model of pericarditis.Apr 01, 2010

Plantago major suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase.Sep 30, 2012

Quercetin was effective in preventing prostate cancer progression by inhibiting the EGFR signaling pathway and by regulating cell adhesion molecules.Sep 30, 2014

Saccharomyces boulardii may have a preventive role in intestinal and colon cancer. Sep 01, 2009

Sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells.Dec 31, 2014

The overall result validated a positive effect of Condurango 30C in ameliorating lung cancer.Aug 31, 2013

10-gingerol showed selective cytotoxicity against malignant T4-2 breast cancer cells, and could revert the malignant phenotype.Jan 22, 2017

Anandamide possessed potent anti-proliferative and cytotoxic effects on metastatic prostatic cancer cells.Jun 14, 2003

Andrographis contains a compound which may induce cancer cell death through epidermal factor receptor and transferrin receptor modulation.Apr 01, 2010

Anti-cancer effects of bifidobacterium species in colon cancer cells and a mouse model of carcinogenesis. Dec 31, 2019

Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway.Apr 30, 2017

Beta-Elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells.Sep 30, 2016

Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells.Jul 24, 2023

Constituents of avocado fruits inhibit human oral cancer cell proliferation. Jun 10, 2011

Cranberry flavonols and PACs possess cytotoxic properties against ovarian cancer cells. Apr 30, 2015

Curcumin and betulinic acid downregulate epidermal growth factor receptor in bladder cancer cells.May 01, 2010

Curcumin and genistein may positively modulate EGF and therefore playing a therapeutic role in periodontal disease. Dec 01, 2004

Curcumin exhibits anticarcinogenic and anti-inflammatory properties.Dec 01, 1997

Curcumin has anti-pancreatic and lung cancer activity.Nov 01, 2006

Curcumin has therapeutic potential in prostate cancer.Jan 01, 2000

Curcumin induces apoptosis of triple-negative breast cancer cells.Sep 25, 2012

Curcumin inhibits epidermal growth factor receptor activity in human epidermoid cancer cells.Dec 30, 1994

Curcumin inhibits human colon cancer cell growth.Jan 12, 2006

Curcumin inhibits ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation associated with tumor cell growth.Aug 01, 1995

Curcumin is able to inhibit directly the enzymatic activity of the EGFR intracellular domain.May 10, 2015

Curcumin may provide an ideal therapy to down-regulate epidermal growth factor receptor activity.Oct 31, 2012

Curcumin suppresses transcription factor Egr-1.Feb 15, 2000

EGCG exhibits anti-cancer activity against tamoxifen-resistant breast cancer lines.Apr 01, 2011

Essential oil of Cinnamon exhibits significant anticancer activity against head and neck squamous cell carcinoma cells in vitro.Oct 31, 2015

Garlic phytocompounds could regulate EGFR expression in colorectal cancer cells.Mar 26, 2017

Grape seed proanthocyanidins, honokiol and EGCG appear to be promising bioactive phytochemicals for the management of head and neck cancer.Nov 23, 2016

Honokiol eliminates glioma/glioblastoma stem cell-like cells and inhibits tumor progression.Dec 25, 2018

Honokiol inhibits growth and the progression of cancers of different organs.Dec 31, 2015

Honokiol is a promising candidate to suppress the development and even progression of lung tumors driven by EGFR deregulation.Jul 20, 2016

Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy.Oct 09, 2017

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.May 06, 2008

Isoliquiritigenin suppresses NSCLC cell growth by directly targeting wild type or mutant EGFR.Dec 25, 2014

Kaempferol may be a safe inhibitor against malignant pancreatic cancers.Dec 31, 2015

Lauric acid induce cell death in colon cancer cells mediated by the epidermal growth factor receptor downregulation.Apr 02, 2019

Litchi seed extract suppressed EGFR signalling and inhibited NSCLC cell growth.Jan 04, 2017

Lupeol may act as a potent inhibitor of the EGFR signalling in oral squamous cell carcinoma.May 31, 2016

Magnolol and honokiol inhibited the function and expression of BCRP with mechanism exploration.Dec 05, 2021

Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.Aug 31, 2007

Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells.Nov 30, 2013

Quercetin-loaded liposomes effectively induced apoptosis and decreased the epidermal growth factor receptor expression in colorectal cancer cells.Apr 30, 2023

Resveratrol inhibits EGF-induced invasion of human lung cancer cells. Apr 01, 2010

Resveratrol may have value as a potential adjunctive treatment for late-stage hormone refractory prostate cancer.Nov 15, 2010

Silibinin prevents the EGFR signaling pathway and may be used as an effective drug for the inhibition of metastasis of human breast cancer.Nov 01, 2011

The combination of erlotinib with shikonin or its derivatives might be a potential strategy to overcome drug resistance to erlotinib.Feb 15, 2015

Therapeutic potential of curcumin and its nanoformulations for treating oral cancer.Jun 19, 2023

This review summarizes in vitro data regarding the interaction of berry polyphenols with the specific receptors and the mechanisms by which they induce cell death.Jun 12, 2012

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Epidermal growth factor receptor (EGFR) inhibitor

View the Evidence:
65 Abstracts with Epidermal growth factor receptor (EGFR) inhibitor Research