Epidermal growth factor receptor (EGFR) inhibitor

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58 Substances Researched for Epidermal growth factor receptor (EGFR) inhibitor
NameACCKFocus
Curcumin1517Locked
Cherry: All Varieties110Locked
Cherry: Bing110Locked
Honokiol55Locked
Omega-3 Fatty Acids24Locked
Curcumol13Locked
EGCG (Epigallocatechin gallate)23Locked
Polyphenols23Locked
Quercetin23Locked
Berberine12Locked
Cannabidiol12Locked
Cucurbitacin B 12Locked
Flaxseed12Locked
Fucoidan12Locked
Ginsenosides12Locked
Graviola 12Locked
Homeopathic Medicine: All12Locked
Luteolin12Locked
Noni12Locked
Noni leaf extract12Locked
Plantago12Locked
Resveratrol22Locked
Saccharomyces Boulardii12Locked
Sulforaphane12Locked
Anandamide11Locked
Andrographis11Locked
Arctigenin11Locked
Avocado11Locked
Berries: All11Locked
Beta-Elemene11Locked
Betulinic acid11Locked
Bifidobacterium Breve11Locked
Caffeic acid phenethyl ester11Locked
Catechin 11Locked
Cinnamon11Locked
Cranberry11Locked
Cucurbitacin E 11Locked
Flavan-3-ols11Locked
Garlic11Locked
Genistein11Locked
Gingerol 11Locked
Grape Seed Extract11Locked
Hydroxytyrosol11Locked
Isoliquiritigenin11Locked
Kaempferol11Locked
Lactobacillus reuteri11Locked
Lauric acid11Locked
Litchi11Locked
Lithospermum erythrorhizon11Locked
Lupeol11Locked
Magnolol11Locked
Myricetin11Locked
Parthenolide11Locked
Proanthocyanidins11Locked
Probiotics11Locked
Shikonin11Locked
Silibinin11Locked
Tanshinone IIA11Locked

View the Evidence:
67 Abstracts with Epidermal growth factor receptor (EGFR) inhibitor Research

[+]

Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans.Feb 28, 2013

Pubmed Data : J Nutr. 2013 Mar ;143(3):340-4. Epub 2013 Jan 23. PMID: 23343675
Article Published Date : Feb 28, 2013
Study Type : Human Study
Additional Links
Substances : Cherry: All Varieties, Cherry: Bing
Diseases : C-Reactive Protein, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Endothelin-1 Inhibitor, Epidermal growth factor receptor (EGFR) inhibitor, Interleukin-18 down-regulation
Additional Keywords : Phytotherapy
[+]

Curcumol exerts antitumor effect via inhibiting EGFR-Akt-Mcl-1 signaling. Mar 01, 2023

Pubmed Data : Am J Chin Med. 2023 Mar 2:1-20. Epub 2023 Mar 2. PMID: 36869017
Article Published Date : Mar 01, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
[+]

Berberine induced senescence of human glioblastoma cells.Jan 31, 2015

Pubmed Data : Mol Cancer Ther. 2015 Feb ;14(2):355-63. Epub 2014 Dec 12. PMID: 25504754
Article Published Date : Jan 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Glioblastoma
Pharmacological Actions : Anti-Tumor, Apoptotic, Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor
[+]

CBD can be used as a novel therapeutic option to inhibit growth and metastasis of highly aggressive breast cancer subtypes including TNBC.Mar 31, 2015

Pubmed Data : Mol Oncol. 2015 Apr ;9(4):906-19. Epub 2015 Jan 19. PMID: 25660577
Article Published Date : Mar 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Anti-metastatic, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor
[+]

Cucurbitacin B administration inhibited MDA-MB-231 orthotopic tumors by 55%, and 4T-1 tumors by 40%.Apr 14, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2014 Apr 15 ;5(7):1812-28. PMID: 24729020
Article Published Date : Apr 14, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Dose Response
[+]

Curcumin holds promise as an adjuvant to broaden the spectrum of gefitinib therapy to improve the efficacy of gefitinib among the NSCLC patients with different EGFR status.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2011 ;6(8):e23756. Epub 2011 Aug 17. PMID: 21858220
Article Published Date : Dec 31, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gefitinib
[+]

Curcumin inhibits amyloid-petpide induced changes associated with the progression of Alzheimer's disease. Dec 01, 2004

Pubmed Data : J Neurochem. 2004 Dec;91(5):1199-210. PMID: 15569263
Article Published Date : Dec 01, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Alzheimer's Disease
Pharmacological Actions : Enzyme Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor, Neuroprotective Agents
[+]

EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2.May 31, 2014

Pubmed Data : Tumour Biol. 2014 Jun ;35(6):5593-8. Epub 2014 Feb 21. PMID: 24557544
Article Published Date : May 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Cell Int. 2019 ;19:43. Epub 2019 Feb 28. PMID: 30858760
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Thyroid Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Flaxseed oil reduces the growth of human breast tumors (MCF-7) at high levels of circulating estrogen.Oct 01, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Oct;54(10):1414-21. PMID: 20425756
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Substances : Flaxseed, Omega-3 Fatty Acids
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Fucoidan exhibits a gastro-protective effect against aspirin-induced ulceration in rats.Jan 31, 2011

Pubmed Data : Int Immunopharmacol. 2011 Feb ;11(2):157-63. Epub 2010 Nov 26. PMID: 21084063
Article Published Date : Jan 31, 2011
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
Problem Substances : Aspirin
Adverse Pharmacological Actions : Ulcerogenic
[+]

Graviola selectively suppresses human breast cancer cells. Jan 01, 2011

Pubmed Data : Nutr Cancer. 2011 ;63(5):795-801. Epub 2011 Jun 22. PMID: 21767082
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Graviola
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor, Oncogene Suppressor
Additional Keywords : Plant Extracts
[+]

Luteolin may be a potential candidate for NSCLC therapy, especially for treatment of patients with acquired erlotinib-resistant NSCLC.May 31, 2014

Pubmed Data : Br J Pharmacol. 2014 Jun ;171(11):2842-53. PMID: 24471765
Article Published Date : May 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Cancers: Drug Resistant, Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Chemotherapeutic Synergy: Erlotinib
[+]

Morinda citrifolia leaf was more effective than the erlotinib in suppressing lung adenocarcinoma in mice. Jan 13, 2016

Pubmed Data : Food Funct. 2016 Jan 14. Epub 2016 Jan 14. PMID: 26765787
Article Published Date : Jan 13, 2016
Study Type : Animal Study
Additional Links
Substances : Noni, Noni leaf extract
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor, Immunomodulatory
Additional Keywords : Dose Response, Superiority of Natural Substances versus Drugs
[+]

Omega-3 polyunsaturated fatty acids has a preventive effect against atrial fibrillation in a canine model of pericarditis.Apr 01, 2010

Pubmed Data : Heart Rhythm. 2010 Apr;7(4):520-8. Epub 2009 Dec 28. PMID: 20156610
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Atrial Fibrillation, Pericarditis
Pharmacological Actions : Cardiovascular Agents, Epidermal growth factor receptor (EGFR) inhibitor, JAM3 gene down-regulation , Myosin heavy chain alpha (MHCalpha) reducer, Protein Kinase Inhibitors
[+]

Plantago major suppress neoplastic cell transformation through the inhibition of epidermal growth factor receptor kinase.Sep 30, 2012

Pubmed Data : Mol Med Rep. 2012 Oct ;6(4):843-7. Epub 2012 Jul 4. PMID: 22767187
Article Published Date : Sep 30, 2012
Study Type : Animal Study
Additional Links
Substances : Plantago
Diseases : Preneoplastic Conditions
Pharmacological Actions : Chemopreventive, Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Plant Extracts
[+]

Quercetin was effective in preventing prostate cancer progression by inhibiting the EGFR signaling pathway and by regulating cell adhesion molecules.Sep 30, 2014

Pubmed Data : Food Funct. 2014 Oct ;5(10):2632-45. Epub 2014 Aug 28. PMID: 25164625
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Polyphenols, Quercetin
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Epidermal growth factor receptor (EGFR) inhibitor, MicroRNA modulator
[+]

Saccharomyces boulardii may have a preventive role in intestinal and colon cancer. Sep 01, 2009

Pubmed Data : Gastroenterology. 2009 Sep;137(3):914-23. Epub 2009 May 29. PMID: 19482027
Article Published Date : Sep 01, 2009
Study Type : Animal Study
Additional Links
Substances : Saccharomyces Boulardii
Diseases : Colon Cancer, Intestinal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biomed Sci. 2015 ;22:38. Epub 2015 Jun 3. PMID: 26036303
Article Published Date : Dec 31, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

The overall result validated a positive effect of Condurango 30C in ameliorating lung cancer.Aug 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2013 Sep ;16(3):11-22. PMID: 25780671
Article Published Date : Aug 31, 2013
Study Type : Animal Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
Problem Substances : Benzo(a)pyrene
[+]

10-gingerol showed selective cytotoxicity against malignant T4-2 breast cancer cells, and could revert the malignant phenotype.Jan 22, 2017

Pubmed Data : J Cell Biochem. 2017 Jan 23. Epub 2017 Jan 23. PMID: 28112417
Article Published Date : Jan 22, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Selective Cytotoxicity
[+]

Anandamide possessed potent anti-proliferative and cytotoxic effects on metastatic prostatic cancer cells.Jun 14, 2003

Pubmed Data : Prostate. 2003 Jun 15 ;56(1):1-12. PMID: 12746841
Article Published Date : Jun 14, 2003
Study Type : In Vitro Study
Additional Links
Substances : Anandamide
Diseases : Prostate Cancer, Prostate Cancer: Metastatic
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Andrographis contains a compound which may induce cancer cell death through epidermal factor receptor and transferrin receptor modulation.Apr 01, 2010

Pubmed Data : Br J Pharmacol. 2010 Apr;159(7):1497-510. Epub 2010 Feb 19. PMID: 20233216
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Andrographis
Diseases : Skin Cancer: Squamous Cell
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor
[+]

Anti-cancer effects of bifidobacterium species in colon cancer cells and a mouse model of carcinogenesis. Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2020 ;15(5):e0232930. Epub 2020 May 13. PMID: 32401801
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bifidobacterium Breve, Lactobacillus reuteri, Probiotics
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Arctigenin induced gallbladder cancer senescence through modulating epidermal growth factor receptor pathway.Apr 30, 2017

Pubmed Data : Tumour Biol. 2017 May ;39(5):1010428317698359. PMID: 28459363
Article Published Date : Apr 30, 2017
Study Type : In Vitro Study
Additional Links
Substances : Arctigenin
Diseases : Gallbladder Cancer
Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
[+]

Beta-Elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2016 Oct ;49(4):1427-36. Epub 2016 Jul 21. PMID: 27498706
Article Published Date : Sep 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Beta-Elemene
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Chemotherapeutic Synergy: Gefitinib
[+]

Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells.Jul 24, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2023 Jul 25 ;116:154860. Epub 2023 May 3. PMID: 37201366
Article Published Date : Jul 24, 2023
Study Type : In Vitro Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Prostate Cancer
Pharmacological Actions : Anti-metastatic, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
[+]

Constituents of avocado fruits inhibit human oral cancer cell proliferation. Jun 10, 2011

Pubmed Data : Biochem Biophys Res Commun. 2011 Jun 10 ;409(3):465-9. Epub 2011 May 8. PMID: 21596018
Article Published Date : Jun 10, 2011
Study Type : In Vitro Study
Additional Links
Substances : Avocado
Diseases : Oral Cancer
Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
[+]

Cranberry flavonols and PACs possess cytotoxic properties against ovarian cancer cells. Apr 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2015 May ;46(5):1924-34. Epub 2015 Mar 17. PMID: 25776829
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cranberry, Flavan-3-ols
Diseases : Ovarian Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer, Cytotoxic, Epidermal growth factor receptor (EGFR) inhibitor, P21 Activation
Additional Keywords : Chemotherapeutic Synergy: Cisplatin
[+]

Cucurbitacin E inhibits the proliferation of glioblastoma cells.Nov 30, 2023

Pubmed Data : Oncol Rep. 2023 Dec ;50(6). Epub 2023 Nov 3. PMID: 37921057
Article Published Date : Nov 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin E
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Cyclin D1 Down-Regulation, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin and betulinic acid downregulate epidermal growth factor receptor in bladder cancer cells.May 01, 2010

Pubmed Data : Mol Cancer Res. 2010 May;8(5):739-50. Epub 2010 Apr 20. PMID: 20407012
Article Published Date : May 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid, Curcumin
Diseases : Bladder Cancer
Pharmacological Actions : Antineoplastic Agents, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin and genistein may positively modulate EGF and therefore playing a therapeutic role in periodontal disease. Dec 01, 2004

Pubmed Data : J Periodontal Res. 2004 Dec;39(6):380-7. PMID: 15491342
Article Published Date : Dec 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Genistein
Diseases : Periodontal Diseases
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin exhibits anticarcinogenic and anti-inflammatory properties.Dec 01, 1997

Pubmed Data : Arterioscler Thromb Vasc Biol. 1997 Dec;17(12):3406-13. PMID: 9437186
Article Published Date : Dec 01, 1997
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: All, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin has anti-pancreatic and lung cancer activity.Nov 01, 2006

Pubmed Data : Anticancer Res. 2006 Nov-Dec;26(6B):4423-30. PMID: 17201164
Article Published Date : Nov 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Lung Cancer, Pancreatic Cancer
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin has therapeutic potential in prostate cancer.Jan 01, 2000

Pubmed Data : Mol Urol. 2000;4(1):1-6. PMID: 10851300
Article Published Date : Jan 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin induces apoptosis of triple-negative breast cancer cells.Sep 25, 2012

Pubmed Data : Mol Med Report. 2012 Sep 26. Epub 2012 Sep 26. PMID: 23023821
Article Published Date : Sep 25, 2012
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : apoptosis, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin inhibits epidermal growth factor receptor activity in human epidermoid cancer cells.Dec 30, 1994

Pubmed Data : Biochim Biophys Acta. 1994 Dec 30;1224(3):597-600. PMID: 7803521
Article Published Date : Dec 30, 1994
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Skin Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin inhibits human colon cancer cell growth.Jan 12, 2006

Pubmed Data : Oncogene. 2006 Jan 12;25(2):278-87. PMID: 16170359
Article Published Date : Jan 12, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin inhibits ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation associated with tumor cell growth.Aug 01, 1995

Pubmed Data : Carcinogenesis. 1995 Aug;16(8):1741-5. PMID: 7634398
Article Published Date : Aug 01, 1995
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Tumors
Pharmacological Actions : Anti-Tumor, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin is able to inhibit directly the enzymatic activity of the EGFR intracellular domain.May 10, 2015

Pubmed Data : Biomacromolecules. 2015 May 11 ;16(5):1634-42. Epub 2015 Apr 24. PMID: 25893361
Article Published Date : May 10, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Squamous cell carcinoma
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin may provide an ideal therapy to down-regulate epidermal growth factor receptor activity.Oct 31, 2012

Pubmed Data : J Mol Recognit. 2012 Nov ;25(11):623-9. PMID: 23108622
Article Published Date : Oct 31, 2012
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Cancers: All
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor
[+]

Curcumin suppresses transcription factor Egr-1.Feb 15, 2000

Pubmed Data : Thromb Res. 2000 Feb 15;97(4):179-89. PMID: 10674404
Article Published Date : Feb 15, 2000
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor
[+]

EGCG exhibits anti-cancer activity against tamoxifen-resistant breast cancer lines.Apr 01, 2011

Pubmed Data : Biosci Rep. 2011 Apr ;31(2):99-108. PMID: 20446926
Article Published Date : Apr 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Catechin
Diseases : Breast Cancer, Cancer Metastasis, Cancers: Drug Resistant
Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : Drug: Tamoxifen, Tamoxifen Resistance
[+]

Essential oil of Cinnamon exhibits significant anticancer activity against head and neck squamous cell carcinoma cells in vitro.Oct 31, 2015

Pubmed Data : J BUON. 2015 Nov-Dec;20(6):1518-25. PMID: 26854449
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cinnamon
Diseases : Head and Neck Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Essential Oils
[+]

Garlic phytocompounds could regulate EGFR expression in colorectal cancer cells.Mar 26, 2017

Pubmed Data : Interdiscip Sci. 2017 Mar 27. Epub 2017 Mar 27. PMID: 28349439
Article Published Date : Mar 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Garlic
Diseases : Colorectal Cancer
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : COLORECTAL CANCER, Epidermal growth factor receptor (EGFR) inhibitor, Garlic
[+]

Grape seed proanthocyanidins, honokiol and EGCG appear to be promising bioactive phytochemicals for the management of head and neck cancer.Nov 23, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2016 Nov 24 ;21(12). Epub 2016 Nov 24. PMID: 27886147
Article Published Date : Nov 23, 2016
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Grape Seed Extract, Honokiol, Proanthocyanidins
Diseases : Head and Neck Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Honokiol eliminates glioma/glioblastoma stem cell-like cells and inhibits tumor progression.Dec 25, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2018 Dec 26 ;11(1). Epub 2018 Dec 26. PMID: 30587839
Article Published Date : Dec 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Glioblastoma, Glioma
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Cancer Stem Cells
[+]

Honokiol inhibits growth and the progression of cancers of different organs.Dec 31, 2015

Pubmed Data : Adv Exp Med Biol. 2016 ;928:245-265. PMID: 27671820
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Bladder Cancer, Breast Cancer, Gastric Cancer, Head and Neck Cancer, Lung Cancer, Melanoma, Neuroblastoma, Prostate Cancer, Skin Cancer: Non-Melanoma
Pharmacological Actions : Antiproliferative , Chemopreventive, Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Honokiol is a promising candidate to suppress the development and even progression of lung tumors driven by EGFR deregulation.Jul 20, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Jul 21. Epub 2016 Jul 21. PMID: 27458163
Article Published Date : Jul 20, 2016
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive, Chemosensitizer, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Chemotherapeutic Synergy: Erlotinib, Superiority of Natural Substances versus Drugs
[+]

Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy.Oct 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Oct 10 ;8(47):83207-83224. Epub 2017 Aug 24. PMID: 29137335
Article Published Date : Oct 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Hydroxytyrosol
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.May 06, 2008

Pubmed Data : J Natl Cancer Inst. 2008 May 7 ;100(9):672-9. Epub 2008 Apr 29. PMID: 18445819
Article Published Date : May 06, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer, Cancer Stem Cells, Cancers: Drug Resistant
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor
Anti Therapeutic Actions : Chemotherapy
Problem Substances : Chemotherapy
[+]

Isoliquiritigenin suppresses NSCLC cell growth by directly targeting wild type or mutant EGFR.Dec 25, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Chem. 2014 Dec 26 ;289(52):35839-48. Epub 2014 Nov 3. PMID: 25368326
Article Published Date : Dec 25, 2014
Study Type : In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Kaempferol may be a safe inhibitor against malignant pancreatic cancers.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(5):e0155264. Epub 2016 May 13. PMID: 27175782
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Pancreatic Cancer, Pancreatic Cancer: Metastatic
Pharmacological Actions : Anti-metastatic, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Dose Response
[+]

Lauric acid induce cell death in colon cancer cells mediated by the epidermal growth factor receptor downregulation.Apr 02, 2019

Pubmed Data : Hum Exp Toxicol. 2019 Apr 3:960327119839185. Epub 2019 Apr 3. PMID: 30942101
Article Published Date : Apr 02, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lauric acid
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Litchi seed extract suppressed EGFR signalling and inhibited NSCLC cell growth.Jan 04, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Jan 5 ;17(1):16. Epub 2017 Jan 5. PMID: 28056952
Article Published Date : Jan 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Litchi
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Plant Extracts
[+]

Lupeol may act as a potent inhibitor of the EGFR signalling in oral squamous cell carcinoma.May 31, 2016

Pubmed Data : Mol Cell Biochem. 2016 Jun ;417(1-2):97-110. Epub 2016 May 20. PMID: 27206736
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Lupeol
Diseases : Oral Cancer, Squamous cell carcinoma
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Magnolol and honokiol inhibited the function and expression of BCRP with mechanism exploration.Dec 05, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Dec 6 ;26(23). Epub 2021 Dec 6. PMID: 34885972
Article Published Date : Dec 05, 2021
Study Type : In Vitro Study
Additional Links
Substances : Honokiol, Magnolol
Diseases : Breast Cancer
Pharmacological Actions : Chemotherapeutic, Epidermal growth factor receptor (EGFR) inhibitor, Multidrug Resistance Gene Modulators
[+]

Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.Aug 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Carcinogenesis. 2007 Sep ;28(9):1918-27. Epub 2007 Aug 11. PMID: 17693661
Article Published Date : Aug 31, 2007
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Cancers: All, Preneoplastic Conditions
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor
[+]

Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells.Nov 30, 2013

Pubmed Data : Int J Oncol. 2013 Dec ;43(6):1895-900. Epub 2013 Oct 14. PMID: 24126683
Article Published Date : Nov 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antioxidants, Enzyme Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor, NF-kappaB Inhibitor
[+]

Quercetin-loaded liposomes effectively induced apoptosis and decreased the epidermal growth factor receptor expression in colorectal cancer cells.Apr 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Med Sci. 2023 May ;48(3):321-328. PMID: 37791331
Article Published Date : Apr 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor
[+]

Resveratrol inhibits EGF-induced invasion of human lung cancer cells. Apr 01, 2010

Pubmed Data : Zhongguo Fei Ai Za Zhi. 2010 Apr;13(4):287-91. PMID: 20677551
Article Published Date : Apr 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Cancer Metastasis, Lung Cancer
Pharmacological Actions : Anti-metastatic, Anticarcinogenic Agents, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Stilbenes
[+]

Resveratrol may have value as a potential adjunctive treatment for late-stage hormone refractory prostate cancer.Nov 15, 2010

Pubmed Data : Hum Mol Genet. 2010 Nov 15;19(22):4319-29. Epub 2010 Aug 20. PMID: 20729295
Article Published Date : Nov 15, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Prostate Cancer
Pharmacological Actions : Anti-Androgen, Antiproliferative , Cell cycle arrest, Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Drug Synergy, Stilbenes
[+]

Silibinin prevents the EGFR signaling pathway and may be used as an effective drug for the inhibition of metastasis of human breast cancer.Nov 01, 2011

Pubmed Data : Anticancer Res. 2011 Nov ;31(11):3767-73. PMID: 22110198
Article Published Date : Nov 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Breast Cancer, Breast Cancer: Metastatic, Cancer Metastasis
Pharmacological Actions : Antioxidants, Epidermal growth factor receptor (EGFR) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]

Tanshinone IIA attenuates osteoarthritis via inhibiting aberrant angiogenesis in subchondral bone.Feb 29, 2024

Pubmed Data : Arch Biochem Biophys. 2024 Mar ;753:109904. Epub 2024 Jan 20. PMID: 38253247
Article Published Date : Feb 29, 2024
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Osteoarthritis
Pharmacological Actions : Angiogenesis Inhibitors, Epidermal growth factor receptor (EGFR) inhibitor
[+]

The combination of erlotinib with shikonin or its derivatives might be a potential strategy to overcome drug resistance to erlotinib.Feb 15, 2015

Pubmed Data : Int J Cancer. 2015 Feb 16. Epub 2015 Feb 16. PMID: 25688715
Article Published Date : Feb 15, 2015
Study Type : In Vitro Study
Additional Links
Substances : Lithospermum erythrorhizon, Shikonin
Diseases : Glioblastoma Multiforme
Pharmacological Actions : Epidermal growth factor receptor (EGFR) inhibitor
Additional Keywords : Chemotherapeutic Synergy: Erlotinib, Drug Resistance
[+]

Therapeutic potential of curcumin and its nanoformulations for treating oral cancer.Jun 19, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Methodol. 2023 Jun 20 ;13(3):29-45. Epub 2023 Jun 20. PMID: 37456978
Article Published Date : Jun 19, 2023
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Oral Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Epidermal growth factor receptor (EGFR) inhibitor, NF-kappaB Inhibitor
[+]

This review summarizes in vitro data regarding the interaction of berry polyphenols with the specific receptors and the mechanisms by which they induce cell death.Jun 12, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Agric Food Chem. 2012 Jun 13 ;60(23):5693-708. Epub 2012 Feb 22. PMID: 22300613
Article Published Date : Jun 12, 2012
Study Type : Review
Additional Links
Substances : Berries: All, Polyphenols
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemopreventive, Epidermal growth factor receptor (EGFR) inhibitor

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