Estrogen Receptor Modulators

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34 Substances Researched for Estrogen Receptor Modulators
NameACCKFocus
Genistein312Locked
Caffeic Acid110Locked
Caffeine110Locked
Hyaluronic Acid110Locked
Resveratrol78Locked
Quercetin26Locked
Silibinin15Locked
Catechin 23Locked
Curcumin23Locked
Polyphenols23Locked
Curcuma Comosa 12Locked
Dandelion 12Locked
Soy Germ: Fermented12Locked
Wogonin12Locked
Allspice11Locked
Apigenin11Locked
Bee Propolis11Locked
Betulinic acid11Locked
CLA (Conjugated Linoleic Acid)11Locked
Estradiol (E(2))11Locked
Huaier (Trametes robiniophila murr)11Locked
Indole-3-Carbinol11Locked
Kaempferol11Locked
Lignans11Locked
Phellinus Linteus11Locked
Pomegranate11Locked
Prunella vulgaris11Locked
Pumpkin Seeds11Locked
Reishi Mushroom11Locked
Rhodiola (Tibetan Ginseng)11Locked
Stilbenes11Locked
Sulforaphane11Locked
Urolithin A 11Locked
Ursolic Acid11Locked

View the Evidence:
39 Abstracts with Estrogen Receptor Modulators Research

[+]

Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption.Feb 16, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cancer Res. 2015 Feb 17. Epub 2015 Feb 17. PMID: 25691730
Article Published Date : Feb 16, 2015
Study Type : Human Study
Additional Links
Substances : Caffeic Acid, Caffeine
Diseases : Breast Cancer, Breast Cancer: Estrogen
Pharmacological Actions : Anti-Tumor, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Estrogen Receptor Modulators, Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords : Dose Response, Risk Reduction
Problem Substances : Tamoxifen
[+]

Vaginally administered genistein and hyaluronic acid both improve symptoms of vaginal atrophy in postmenopausal women.May 31, 2011

Pubmed Data : Arch Gynecol Obstet. 2011 Jun ;283(6):1319-23. Epub 2010 Jun 25. PMID: 20577750
Article Published Date : May 31, 2011
Study Type : Human Study
Additional Links
Substances : Genistein, Hyaluronic Acid
Diseases : Atrophic Vaginitis (Vaginal Atrophy)
Pharmacological Actions : Estrogen Receptor Modulators
[+]

Quercetin stimulates bone marrow mesenchymal stem cell differentiation through an estrogen receptor-mediated pathway.Jan 01, 2018

Pubmed Data : Biomed Res Int. 2018 ;2018:4178021. Epub 2018 Mar 15. PMID: 29736392
Article Published Date : Jan 01, 2018
Study Type : Human In Vitro
Additional Links
Substances : Quercetin
Pharmacological Actions : Estrogen Receptor Modulators, Osteogenic, Osteoprotective , Regenerative
Additional Keywords : Bone Regeneration
[+]

Treatment with silibinin of ERα-positive MCF-7 cells down-regulates the expression of ERα.May 11, 2015

Pubmed Data : J Pharmacol Sci. 2015 May 12. Epub 2015 May 12. PMID: 26117209
Article Published Date : May 11, 2015
Study Type : Human In Vitro
Additional Links
Substances : Silibinin
Diseases : Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Apoptotic, Autophagy Up-regulation, Estrogen Receptor Modulators
[+]

Methyl-hispolon from Phellinus lonicerinus affects estrogen signals in MCF-7 breast cancer cells and premature aging in rats.Dec 31, 2018

Pubmed Data : Int J Med Mushrooms. 2019 ;21(4):381-392. PMID: 31002633
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Polyphenols
Diseases : Aging, Breast Cancer
Pharmacological Actions : Antiproliferative , Estrogen Receptor Modulators
Additional Keywords : Estrogen Receptor Beta
[+]

A new soy germ fermented ingredient displays estrogenic and protease inhibitor activities able to prevent irritable bowel syndrome-like symptoms in stressed female rats.Jun 21, 2012

Pubmed Data : Clin Nutr. 2012 Jun 22. Epub 2012 Jun 22. PMID: 22727545
Article Published Date : Jun 21, 2012
Study Type : Animal Study
Additional Links
Substances : Soy Germ: Fermented
Diseases : Irritable Bowel Syndrome
Pharmacological Actions : Estrogen Receptor Modulators, HIV Protease Inhibitors
[+]

Curcuma cornosa compares favorably with estradiol in improving spatial memory in ovariectomized rats.Jan 01, 2011

Pubmed Data : J Nat Med. 2011 Jan;65(1):57-62. Epub 2010 Sep 3. PMID: 20814755
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Curcuma Comosa
Diseases : Memory Impairment: Hormone Deficiency Induced
Pharmacological Actions : Estrogen Receptor Modulators
Additional Keywords : Ovariectomy-Induced Changes, Plant Extracts
[+]

Dandelion extract up-regulates reproductive hormone receptor expression in mice.Sep 01, 2007

Pubmed Data : Int J Mol Med. 2007 Sep;20(3):287-92. PMID: 17671731
Article Published Date : Sep 01, 2007
Study Type : Animal Study
Additional Links
Substances : Dandelion
Diseases : Infertility: Female
Pharmacological Actions : ER alpha receptor up-regulation, ER beta receptor up-regulation, Estrogen Receptor Modulators, Follicle-stimulating hormone receptor (FSHR) up-regulation, Progesterone receptor (PR) up-regulation
Additional Keywords : Estrogen Receptor Beta, Plant Extracts
[+]

Electroacupuncture at sensitization points and CV4 can regulate the expression of estrogen and ER-α in polycystic ovary syndrome.May 24, 2022

Pubmed Data : Zhen Ci Yan Jiu. 2022 May 25 ;47(5):377-85. PMID: 35616410
Article Published Date : May 24, 2022
Study Type : Animal Study
Additional Links
Diseases : Anxiety, Bisphenol Toxicity, Polycystic Ovary Syndrome
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Anxiety Agents, Estrogen Receptor Modulators
Problem Substances : Bisphenol A
[+]

Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposureMar 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Reprod Toxicol. 2007 Apr-May;23(3):383-90. Epub 2006 Oct 24. PMID: 17123778
Article Published Date : Mar 31, 2007
Study Type : Animal Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: Prevention, Prenatal Chemical Exposures
Pharmacological Actions : Estrogen Receptor Modulators
Problem Substances : Bisphenol A
Adverse Pharmacological Actions : Carcinogenic
[+]

Resveratrol inhibits restenosis in an animal model. Nov 01, 2010

Pubmed Data : Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1451-8. Epub 2010 Aug 13. PMID: 20709862
Article Published Date : Nov 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Restenosis
Pharmacological Actions : Antiproliferative , Enzyme Inhibitors, Estrogen Receptor Modulators, Nitric Oxide Inhibitor
Additional Keywords : Stilbenes
[+]

The combination of epigallocatechin gallate and curcumin suppresses ER alpha-breast cancer cell growth in vitro and in vivo.May 01, 2008

Pubmed Data : Int J Cancer. 2008 May 1;122(9):1966-71. PMID: 18098290
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Catechin , Curcumin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Estrogen Receptor Modulators, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : ER Alpha-Breast Cancer
[+]

Wogonin has anticancer activity in both ER-positive and -negative breast cancer cells. Feb 15, 2008

Pubmed Data : Int J Cancer. 2008 Feb 15;122(4):816-22. PMID: 17957784
Article Published Date : Feb 15, 2008
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Estrogen Receptor Modulators
[+]

All spice (P. dioca) has estrogenic effects and has been used by Costa Rican women to treat menopausal symptoms. Jul 01, 2009

Pubmed Data : Menopause. 2009 Jul-Aug;16(4):748-55. PMID: 19424091
Article Published Date : Jul 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Allspice
Diseases : Menopausal Syndrome
Pharmacological Actions : Estrogen Receptor Modulators
[+]

Apigenin inhibits antiestrogen-resistant breast cancer cell growth. Nov 01, 2006

Pubmed Data : J Pineal Res. 2006 Nov;41(4):358-62. PMID: 18645020
Article Published Date : Nov 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Breast Cancer, Cancers: Drug Resistant
Pharmacological Actions : Antiproliferative , Estrogen Receptor Modulators, Selective estrogen enzyme modulator (SEEM)
Additional Keywords : Drug-Plant-Vitamin Synergies
[+]

Bee propolis contains a component which is a novel selective estrogen receptor modulator. Feb 01, 2010

Pubmed Data : Phytother Res. 2010 Feb;24(2):295-300. PMID: 19655397
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Bee Propolis
Pharmacological Actions : Antiproliferative , Estrogen Receptor Modulators, Selective estrogen enzyme modulator (SEEM)
[+]

Betulinic acid and ursolic acid have potential use as therapeutic agents against estrogen-dependent tumors.Aug 21, 2014

Pubmed Data : Biochem Biophys Res Commun. 2014 Aug 22 ;451(2):282-7. Epub 2014 Aug 1. PMID: 25088993
Article Published Date : Aug 21, 2014
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid, Prunella vulgaris, Ursolic Acid
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive, Prostate Cancer
Pharmacological Actions : Estrogen Receptor Modulators
[+]

BPA at environmentally relevant doses reduces the efficacy of chemotherapeutic agents doxorubicin, cisplatin, and vinblastine.Jan 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Health Perspect. 2009 Feb ;117(2):175-80. Epub 2008 Oct 8. PMID: 19270784
Article Published Date : Jan 31, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive, Breast Cancer: Triple Negative
Pharmacological Actions : Apoptotic, Estrogen Receptor Modulators
Additional Keywords : Drug: Cisplatin, Drug: Doxorubicin, Drug: Vinblastine
Problem Substances : Bisphenol A
Adverse Pharmacological Actions : Chemoresistance upregulation
[+]

BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 cells.Sep 30, 2012

Pubmed Data : J Nutr Biochem. 2012 Oct ;23(10):1324-32. Epub 2011 Dec 23. PMID: 22197621
Article Published Date : Sep 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Breast Cancer
Pharmacological Actions : Estrogen Receptor Modulators
Problem Substances : Dioxins
[+]

BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.Feb 12, 2006

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Cancer. 2006 Feb 13 ;94(3):407-26. PMID: 16434996
Article Published Date : Feb 12, 2006
Study Type : In Vitro Study
Additional Links
Substances : Genistein, Indole-3-Carbinol
Diseases : Breast Cancer, Breast Cancer: BRCA1, Prostate Cancer
Pharmacological Actions : Chemopreventive, Estrogen Receptor Modulators
[+]

Curcumin exhibits estrogen-like activity.Jan 01, 2010

Pubmed Data : Cell Physiol Biochem. 2010;26(3):471-82. Epub 2010 Aug 24. PMID: 20798532
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin, Lignans, Quercetin
Diseases : Estrogen Deficiency
Pharmacological Actions : Estrogen Receptor Modulators
[+]

EGCG is capable of killing tamoxifen-resistant breast cancer cells.Jan 01, 2007

Pubmed Data : Cancer Detect Prev. 2007 ;31(6):499-504. PMID: 18061364
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Catechin
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Estrogen Receptor Modulators
Additional Keywords : Drug: Tamoxifen, Tamoxifen Resistance
[+]

Estradiol may play a role in the neuroprotection of spinal astrocytes in amyotrophic lateral sclerosis patients.Nov 01, 2005

Pubmed Data : Neurobiol Dis. 2005 Nov;20(2):461-70. PMID: 15893467
Article Published Date : Nov 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Estradiol (E(2))
Diseases : Amyotrophic Lateral Sclerosis
Pharmacological Actions : Estrogen Receptor Modulators, Neuroprotective Agents
[+]

Estrogen-like activity of metals in MCF-7 breast cancer cells.May 31, 2003

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Endocrinology. 2003 Jun ;144(6):2425-36. PMID: 12746304
Article Published Date : May 31, 2003
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer
Pharmacological Actions : Estrogen Receptor Modulators
Additional Keywords : Metalloestrogens
Problem Substances : Cobalt, Industrial Copper (inorganic), Lead, Nickel, unspecified type, Tin
Adverse Pharmacological Actions : Estrogenic
[+]

Genistein derivatives inhibit estrogen receptor alpha-positive breast cancer.May 15, 2011

Pubmed Data : Cancer Biol Ther. 2011 May 15 ;11(10):883-92. Epub 2011 May 15. PMID: 21389782
Article Published Date : May 15, 2011
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Antiproliferative , Apoptotic, Estrogen Receptor Modulators
Additional Keywords : Estrogen Receptor Beta
[+]

Hispolon inhibits the growth of estrogen receptor positive human breast cancer cells through modulation of estrogen receptor alpha.Aug 06, 2015

Pubmed Data : Biochem Biophys Res Commun. 2015 Aug 7 ;463(4):917-22. Epub 2015 Jun 6. PMID: 26056942
Article Published Date : Aug 06, 2015
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus, Polyphenols
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Estrogen Receptor Modulators
[+]

Huaier extract is a novel estrogen receptor modulator and is a promising drug for the prevention and treatment of ERα-positive human breast cancers.Jun 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Oncol. 2013 Jul ;43(1):321-8. Epub 2013 May 20. PMID: 23686317
Article Published Date : Jun 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Huaier (Trametes robiniophila murr)
Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive
Pharmacological Actions : Antiproliferative , Chemopreventive, Estrogen Receptor Modulators, NF-kappaB Inhibitor
Additional Keywords : Plant Extracts
[+]

Pomegranate seed compounds have estrogen receptor enzyme modulating activity.Aug 01, 2007

Pubmed Data : Atherosclerosis. 2007 Aug;193(2):277-82. Epub 2006 Sep 29. PMID: 20136514
Article Published Date : Aug 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid), Pomegranate
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Estrogen Receptor Modulators, Selective estrogen enzyme modulator (SEEM), Selective Estrogen Receptor Modulators
Additional Keywords : Estrogen Receptor Beta
[+]

Pumpkin seed's lignans could have a potential role in breast cancer prevention and treatment.Dec 31, 2012

Pubmed Data : Nutr Cancer. 2013 ;65(5):739-45. PMID: 23859042
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive, Estrogen Receptor Modulators
Additional Keywords : Estrogen Receptor Beta, Plant Extracts
[+]

R. rosea should be investigated as a potential selective estrogen receptor modulator to prevent or delay menopause-related conditions.Dec 11, 2015

Pubmed Data : Phytomedicine. 2015 Dec 12. Epub 2015 Dec 12. PMID: 26776957
Article Published Date : Dec 11, 2015
Study Type : Review
Additional Links
Substances : Rhodiola (Tibetan Ginseng)
Diseases : Cognitive Decline/Dysfunction, Postmenopausal Disorders: Memory Impairment
Pharmacological Actions : Anti-Inflammatory Agents, Estrogen Receptor Modulators, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Reishi inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappa B signaling. Sep 01, 2006

Pubmed Data : Int J Oncol. 2006 Sep;29(3):695-703. PMID: 16865287
Article Published Date : Sep 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Reishi Mushroom
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Estrogen Receptor Modulators, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Estrogen Receptor Beta, Plant Extracts
[+]

Resveratraol and kaempferol exhibit anti-breast cancer activity. Dec 28, 2010

Pubmed Data : Cancer Lett. 2010 Dec 28;299(2):119-29. Epub 2010 Sep 16. PMID: 20846786
Article Published Date : Dec 28, 2010
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol, Resveratrol
Diseases : Breast Cancer
Pharmacological Actions : Estrogen Receptor Modulators
Additional Keywords : Stilbenes
[+]

Resveratrol and 3,3'-diindolylmethane differentially regulate aryl hydrocarbon receptor and estrogen receptor alpha activity.Sep 25, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Sep 26 ;24(19). Epub 2023 Sep 26. PMID: 37834026
Article Published Date : Sep 25, 2023
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Breast Cancer
Pharmacological Actions : Estrogen Receptor Modulators
[+]

Resveratrol exhibits anti-cancer properties against tamoxifen-resistant breast cancer cells.Sep 30, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : FASEB J. 2011 Oct ;25(10):3695-707. Epub 2011 Jul 7. PMID: 21737614
Article Published Date : Sep 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Breast Cancer: Drug Resistant
Pharmacological Actions : Estrogen Receptor Modulators, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Tamoxifen Resistance
Problem Substances : Tamoxifen
[+]

Resveratrol may prevent epigenetic silencing of the BRCA-1 gene by the aromatic hydrocarbon receptor in human breast cancer cells.Sep 01, 2010

Pubmed Data : J Nutr. 2010 Sep;140(9):1607-14. Epub 2010 Jul 14. PMID: 20631324
Article Published Date : Sep 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Breast Cancer, Breast Cancer: BRCA1, DNA damage
Pharmacological Actions : Anticarcinogenic Agents, Estrogen Receptor Modulators
Additional Keywords : Epigenetic Modification, Stilbenes
[+]

Resveratrol may repress aryl hydrocarbon receptor activity in cancer cell lines. Nov 01, 2010

Pubmed Data : J Pharmacol Exp Ther. 2010 Nov;335(2):273-83. Epub 2010 Aug 17. PMID: 20716622
Article Published Date : Nov 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Dioxin Toxicity , Polycyclic aromatic hydrocarbon (PAH) toxicity
Pharmacological Actions : Chemopreventive, Estrogen Receptor Modulators
Additional Keywords : Stilbenes
[+]

Sulforaphane regulates estrogen receptor alpha expression in human bresat cancer cells in a manner which may inhibit proliferation and down-regulate hormone receptor expression.Mar 01, 2009

Pubmed Data : J Nutr Biochem. 2009 Mar;20(3):195-201. Epub 2008 Jul 7. PMID: 18602823
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Estrogen Receptor Modulators
[+]

The timing and manner of fixation of a breast biopsy sample may determine the immunohistochemical outcome.Jan 01, 2007

Pubmed Data : Breast Cancer. 2007;14(2):182-8. PMID: 17485904
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer
Pharmacological Actions : Estrogen Receptor Modulators
Anti Therapeutic Actions : Breast Biopsy
[+]

Urolithin A: A promising selective estrogen receptor modulator and 27-hydroxycholesterol attenuator in breast cancer.Jun 20, 2023

Pubmed Data : Phytother Res. 2023 Jun 21. Epub 2023 Jun 21. PMID: 37345359
Article Published Date : Jun 20, 2023
Study Type : In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Estrogen Receptor Modulators

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