Heat Shock Protein Down-Regulation

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26 Substances Researched for Heat Shock Protein Down-Regulation
NameACCKFocus
Beta Sitosterol15Locked
Kahweol15Locked
Ginkgo biloba23Locked
Ginsenosides23Locked
Hesperidin23Locked
Agaricus Blazei12Locked
Ashwagandha12Locked
Bael 12Locked
Curcumin22Locked
DHA (Docosahexaenoic Acid)12Locked
Diosgenin12Locked
Grape Seed Extract12Locked
Melatonin12Locked
Myricetin12Locked
Pomegranate12Locked
Vitamin D12Locked
Betulinic acid11Locked
Cannabidiol11Locked
Carvacrol11Locked
Gallic Acid11Locked
Lemongrass: Essential Oil11Locked
Luteolin11Locked
Resveratrol11Locked
Stilbenes11Locked
Theaflavins11Locked
Ursolic Acid11Locked

View the Evidence:
28 Abstracts with Heat Shock Protein Down-Regulation Research

[+]

Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells.Dec 31, 2017

Pubmed Data : Biochem Pharmacol. 2018 06 ;152:60-70. Epub 2018 Mar 17. PMID: 29559312
Article Published Date : Dec 31, 2017
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Beta Sitosterol
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Heat Shock Protein Down-Regulation
[+]

Kahweol inhibits colorectal tumor cell growth by promoting apoptosis and suppressing HSP70 expression.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 Mar ;23(2):128-33. Epub 2015 Mar 1. PMID: 25767680
Article Published Date : Feb 28, 2015
Study Type : Human In Vitro
Additional Links
Substances : Kahweol
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Heat Shock Protein Down-Regulation
[+]

Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β.Jun 10, 2020

Pubmed Data : Biochem Pharmacol. 2020 Jun 11 ;178:114097. Epub 2020 Jun 11. PMID: 32535102
Article Published Date : Jun 10, 2020
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Heat Shock Protein Down-Regulation, Transforming growth factor beta (TGF-β) inhibitor
[+]

A ashwagandha water extract suppressed the tumor growth of glioma cells.Jul 25, 2015

Pubmed Data : Mol Neurobiol. 2015 Jul 26. Epub 2015 Jul 26. PMID: 26208698
Article Published Date : Jul 25, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ashwagandha
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Heat Shock Protein Down-Regulation, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Plant Extracts
[+]

Anti-inflammatory mechanisms could be involved in pomegranate-mediated prevention of breast cancer.Apr 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Apr 28 ;9(5). Epub 2017 Apr 28. PMID: 28452959
Article Published Date : Apr 27, 2017
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation
[+]

Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70.Aug 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Aug 3 ;8(1):11707. Epub 2018 Aug 3. PMID: 30076345
Article Published Date : Aug 02, 2018
Study Type : Animal Study
Additional Links
Substances : Diosgenin
Diseases : Alzheimer's Disease
Pharmacological Actions : Heat Shock Protein Down-Regulation, Neuroprotective Agents
[+]

Ginkgolic acids from G. biloba might represent promising Hsp90 inhibitors for the development of anti-nasopharyngeal carcinoma agents.Oct 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Oct 30 ;26(21). Epub 2021 Oct 30. PMID: 34770993
Article Published Date : Oct 29, 2021
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Heat Shock Protein Down-Regulation
[+]

Ginsenoside Rg2 may represent a potential treatment strategy for vascular dementia or other ischemic insults.Feb 11, 2008

Pubmed Data : J Ethnopharmacol. 2008 Feb 12 ;115(3):441-8. Epub 2007 Oct 25. PMID: 18083315
Article Published Date : Feb 11, 2008
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Dementia, Memory Disorders
Pharmacological Actions : Anti-Apoptotic, Heat Shock Protein Down-Regulation, Neuroprotective Agents
[+]

Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension.Apr 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 May ;101:123-128. Epub 2018 Feb 23. PMID: 29482057
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Hypertension: Pulmonary
Pharmacological Actions : Heat Shock Protein Down-Regulation
Additional Keywords : Proanthocyanidins
[+]

Hesperidin has protective effect against sepsis-induced lung injury.Jan 03, 2019

Pubmed Data : Med Sci Monit. 2019 Jan 4 ;25:107-114. Epub 2019 Jan 4. PMID: 30608918
Article Published Date : Jan 03, 2019
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heat Shock Protein Down-Regulation
[+]

Melatonin can be useful as a therapeutic adjuvant for patients under long-term opioid treatment for pain relief.Mar 20, 2016

Pubmed Data : Life Sci. 2016 Mar 21. Epub 2016 Mar 21. PMID: 27012766
Article Published Date : Mar 20, 2016
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Brain Inflammation , Morphine Tolerance/Dependence
Pharmacological Actions : Anti-Inflammatory Agents, Heat Shock Protein Down-Regulation
[+]

Results suggest that Agaricus blazei polysaccharide for the mitigation of damage induced by cadmium in chicken testis.Nov 09, 2017

Pubmed Data : Biol Trace Elem Res. 2017 Nov 10. Epub 2017 Nov 10. PMID: 29127548
Article Published Date : Nov 09, 2017
Study Type : Animal Study
Additional Links
Substances : Agaricus Blazei
Diseases : Testicular Injury: Cadmium-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Heat Shock Protein Down-Regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These data support a role for dietary intervention to improve cancer therapy in tumors overexpressing Hsp90 and its client proteins.Nov 22, 2016

Pubmed Data : Nutr Cancer. 2016 Nov 23:1-13. Epub 2016 Nov 23. PMID: 27880046
Article Published Date : Nov 22, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : DHA (Docosahexaenoic Acid)
Diseases : Breast Cancer, Lung Cancer
Pharmacological Actions : Heat Shock Protein Down-Regulation, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
Additional Keywords : Dose Response
[+]

This study demonstrates the anti-fatigue properties of A. marmelos fruit.Apr 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2014 May ;52(5):551-9. Epub 2014 Feb 6. PMID: 24707972
Article Published Date : Apr 30, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bael
Diseases : Fatigue: Excercise-Induced, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Heat Shock Protein Down-Regulation
Additional Keywords : Plant Extracts
[+]

Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.Jul 24, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2015 Jul 25 ;34:71. Epub 2015 Jul 25. PMID: 26205949
Article Published Date : Jul 24, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Betulinic acid modulates the expression of HSPA and activates apoptosis in two cell lines of human colorectal cancer.Oct 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Oct 22 ;26(21). Epub 2021 Oct 22. PMID: 34770786
Article Published Date : Oct 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Heat Shock Protein Down-Regulation, Heat Shock Protein Inducer
[+]

Cannabidiol-induced crosstalk of apoptosis and macroautophagy in colorectal cancer cells.Aug 04, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Discov. 2023 Aug 5 ;9(1):286. Epub 2023 Aug 5. PMID: 37542074
Article Published Date : Aug 04, 2023
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Heat Shock Protein Down-Regulation
[+]

Computational investigation of ginkgetin and theaflavin as potential inhibitors of heat shock protein 90.Dec 31, 2021

Pubmed Data : J Biomol Struct Dyn. 2022 ;40(24):13675-13681. Epub 2021 Oct 25. PMID: 34693877
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba, Theaflavins
Diseases : Cancers: All
Pharmacological Actions : Heat Shock Protein Down-Regulation
[+]

Curcumin enhanced the efficacy of anti-tumor drugs imatinib-mesylate and cytarabine through the inhibition of the tumor markers.Dec 31, 2013

Pubmed Data : J Environ Pathol Toxicol Oncol. 2014 ;33(3):247-63. PMID: 25272063
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia, Oxidative Stress
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cell cycle arrest, Heat Shock Protein Down-Regulation
Additional Keywords : Chemothapeutic Synergy: Cytarabine, Chemothapeutic Synergy: Imatinib
[+]

Essential oil from Cymbopogon flexuosus as the potential inhibitor for HSP90.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Rep. 2018 ;5:489-496. Epub 2018 Apr 5. PMID: 29854620
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lemongrass: Essential Oil
Diseases : Breast Cancer, Cancers: All
Pharmacological Actions : Chemotherapeutic, Heat Shock Protein Down-Regulation
Additional Keywords : Essential Oils
[+]

Gallic acid has an inhibitory effect on skin squamous cell carcinoma.Jan 29, 2023

Pubmed Data : Gene. 2023 Jan 30 ;851:147041. Epub 2022 Nov 12. PMID: 36375658
Article Published Date : Jan 29, 2023
Study Type : In Vitro Study
Additional Links
Substances : Gallic Acid
Diseases : Skin Cancer, Squamous cell carcinoma
Pharmacological Actions : Anti-metastatic, Heat Shock Protein Down-Regulation
[+]

Ginsenoside Rg1 could inhibit cerebral ischemia-induced nerve cell apoptosis.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2016 Jul ;11(7):1159-64. PMID: 27630703
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Cerebral Ischemia, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Heat Shock Protein Down-Regulation, Neuroprotective Agents
Additional Keywords : Dose Response
[+]

Hesperetin induces apoptosis in A549 cells via the Hsp70‑mediated activation of Bax.Nov 30, 2022

Pubmed Data : Int J Oncol. 2022 Dec ;61(6). Epub 2022 Oct 5. PMID: 36196892
Article Published Date : Nov 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Hesperidin
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Heat Shock Protein Down-Regulation
[+]

Luteolin can relieve the lesions and symptoms of psoriasis through reversing the effects of IFN-γ, inhibiting the expression and exosome secretion of HSP90.Jan 31, 2020

Pubmed Data : Int Immunopharmacol. 2020 Feb ;79:106070. Epub 2020 Jan 6. PMID: 31918062
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Psoriasis
Pharmacological Actions : Heat Shock Protein Down-Regulation, Immunomodulatory, Interferon Gamma Reducer
Additional Keywords : Exosomes
[+]

Resveratrol has chemotherapeutic potential in treating chronic myelogenous leukemia.Jan 01, 2010

Pubmed Data : PLoS One. 2010;5(1):e8719. Epub 2010 Jan 14. PMID: 20090934
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Heat Shock Protein Down-Regulation
Additional Keywords : Drug Synergy
[+]

Thermotherapy in combination with chemotherapy showed more strong inhibitory effect than those of thermotherapy or chemotherapy alone.Aug 31, 2008

Pubmed Data : Wei Sheng Yan Jiu. 2008 Sep ;37(5):529-32. PMID: 19069644
Article Published Date : Aug 31, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Lung Cancer
Therapeutic Actions : Heat Therapy
Pharmacological Actions : Heat Shock Protein Down-Regulation
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Therapeutic Action Synergy with Drugs
[+]

This study reported that the pharmacogenomics of curcumin are similar to that of the antiviral drug, geldanamycin.Jun 21, 2015

Pubmed Data : Mol Med Rep. 2015 Jun 22. Epub 2015 Jun 22. PMID: 26100249
Article Published Date : Jun 21, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cytomegalovirus Infections
Pharmacological Actions : Antiviral Agents, Heat Shock Protein Down-Regulation
Additional Keywords : Natural Substances Versus Drugs
[+]

Ursolic acid and carvacrol may be potential inhibitors of dormancy protein small heat shock protein16.3 of Mycobacterium tuberculosis.Sep 30, 2018

Pubmed Data : J Biomol Struct Dyn. 2018 Oct ;36(13):3434-3443. Epub 2017 Oct 20. PMID: 28984500
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Ursolic Acid
Diseases : Mycobacterium Tuberculosis
Pharmacological Actions : Heat Shock Protein Down-Regulation

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