Heat Shock Protein Down-Regulation

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21 Substances Researched for Heat Shock Protein Down-Regulation
NameACCKFocus
Beta Sitosterol15Locked
Kahweol15Locked
Ginsenosides23Locked
Agaricus Blazei12Locked
Ashwagandha12Locked
Bael 12Locked
Curcumin22Locked
DHA (Docosahexaenoic Acid)12Locked
Diosgenin12Locked
Grape Seed Extract12Locked
Hesperidin12Locked
Melatonin12Locked
Myricetin12Locked
Pomegranate12Locked
Vitamin D12Locked
Carvacrol11Locked
Lemongrass: Essential Oil11Locked
Luteolin11Locked
Resveratrol11Locked
Stilbenes11Locked
Ursolic Acid11Locked

View the Evidence:
28 Abstracts with Heat Shock Protein Down-Regulation Research

[+]

Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells.Dec 31, 2017

Pubmed Data : Biochem Pharmacol. 2018 06 ;152:60-70. Epub 2018 Mar 17. PMID: 29559312
Article Published Date : Dec 31, 2017
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Beta Sitosterol
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic, Heat Shock Protein Down-Regulation
[+]

Kahweol inhibits colorectal tumor cell growth by promoting apoptosis and suppressing HSP70 expression.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomol Ther (Seoul). 2015 Mar ;23(2):128-33. Epub 2015 Mar 1. PMID: 25767680
Article Published Date : Feb 28, 2015
Study Type : Human In Vitro
Additional Links
Substances : Kahweol
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Heat Shock Protein Down-Regulation
[+]

Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β.Jun 10, 2020

Pubmed Data : Biochem Pharmacol. 2020 Jun 11 ;178:114097. Epub 2020 Jun 11. PMID: 32535102
Article Published Date : Jun 10, 2020
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Chemoprotective Agents, Heat Shock Protein Down-Regulation, Transforming growth factor beta (TGF-β) inhibitor
[+]

A ashwagandha water extract suppressed the tumor growth of glioma cells.Jul 25, 2015

Pubmed Data : Mol Neurobiol. 2015 Jul 26. Epub 2015 Jul 26. PMID: 26208698
Article Published Date : Jul 25, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ashwagandha
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Heat Shock Protein Down-Regulation, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Plant Extracts
[+]

Anti-inflammatory mechanisms could be involved in pomegranate-mediated prevention of breast cancer.Apr 27, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Apr 28 ;9(5). Epub 2017 Apr 28. PMID: 28452959
Article Published Date : Apr 27, 2017
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Breast Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation
[+]

Diosgenin restores Aβ-induced axonal degeneration by reducing the expression of heat shock cognate 70.Aug 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2018 Aug 3 ;8(1):11707. Epub 2018 Aug 3. PMID: 30076345
Article Published Date : Aug 02, 2018
Study Type : Animal Study
Additional Links
Substances : Diosgenin
Diseases : Alzheimer's Disease
Pharmacological Actions : Heat Shock Protein Down-Regulation, Neuroprotective Agents
[+]

Ginkgolic acids from G. biloba might represent promising Hsp90 inhibitors for the development of anti-nasopharyngeal carcinoma agents.Oct 29, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Oct 30 ;26(21). Epub 2021 Oct 30. PMID: 34770993
Article Published Date : Oct 29, 2021
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Nasopharyngeal Cancer
Pharmacological Actions : Antiproliferative , Heat Shock Protein Down-Regulation
[+]

Ginsenoside Rg2 may represent a potential treatment strategy for vascular dementia or other ischemic insults.Feb 11, 2008

Pubmed Data : J Ethnopharmacol. 2008 Feb 12 ;115(3):441-8. Epub 2007 Oct 25. PMID: 18083315
Article Published Date : Feb 11, 2008
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Dementia, Memory Disorders
Pharmacological Actions : Anti-Apoptotic, Heat Shock Protein Down-Regulation, Neuroprotective Agents
[+]

Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension.Apr 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 May ;101:123-128. Epub 2018 Feb 23. PMID: 29482057
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Hypertension: Pulmonary
Pharmacological Actions : Heat Shock Protein Down-Regulation
Additional Keywords : Proanthocyanidins
[+]

Hesperidin has protective effect against sepsis-induced lung injury.Jan 03, 2019

Pubmed Data : Med Sci Monit. 2019 Jan 4 ;25:107-114. Epub 2019 Jan 4. PMID: 30608918
Article Published Date : Jan 03, 2019
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heat Shock Protein Down-Regulation
[+]

Melatonin can be useful as a therapeutic adjuvant for patients under long-term opioid treatment for pain relief.Mar 20, 2016

Pubmed Data : Life Sci. 2016 Mar 21. Epub 2016 Mar 21. PMID: 27012766
Article Published Date : Mar 20, 2016
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Brain Inflammation , Morphine Tolerance/Dependence
Pharmacological Actions : Anti-Inflammatory Agents, Heat Shock Protein Down-Regulation
[+]

Results suggest that Agaricus blazei polysaccharide for the mitigation of damage induced by cadmium in chicken testis.Nov 09, 2017

Pubmed Data : Biol Trace Elem Res. 2017 Nov 10. Epub 2017 Nov 10. PMID: 29127548
Article Published Date : Nov 09, 2017
Study Type : Animal Study
Additional Links
Substances : Agaricus Blazei
Diseases : Testicular Injury: Cadmium-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Heat Shock Protein Down-Regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These data support a role for dietary intervention to improve cancer therapy in tumors overexpressing Hsp90 and its client proteins.Nov 22, 2016

Pubmed Data : Nutr Cancer. 2016 Nov 23:1-13. Epub 2016 Nov 23. PMID: 27880046
Article Published Date : Nov 22, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : DHA (Docosahexaenoic Acid)
Diseases : Breast Cancer, Lung Cancer
Pharmacological Actions : Heat Shock Protein Down-Regulation, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
Additional Keywords : Dose Response
[+]

This study demonstrates the anti-fatigue properties of A. marmelos fruit.Apr 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2014 May ;52(5):551-9. Epub 2014 Feb 6. PMID: 24707972
Article Published Date : Apr 30, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bael
Diseases : Fatigue: Excercise-Induced, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Heat Shock Protein Down-Regulation
Additional Keywords : Plant Extracts
[+]

Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/β-catenin pathway.Jul 24, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Clin Cancer Res. 2015 Jul 25 ;34:71. Epub 2015 Jul 25. PMID: 26205949
Article Published Date : Jul 24, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Colon Cancer
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Heat Shock Protein Down-Regulation, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Chemothapeutic Synergy: 5-flourouracil
[+]

Betulinic acid modulates the expression of HSPA and activates apoptosis in two cell lines of human colorectal cancer.Oct 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2021 Oct 22 ;26(21). Epub 2021 Oct 22. PMID: 34770786
Article Published Date : Oct 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Heat Shock Protein Down-Regulation, Heat Shock Protein Inducer
[+]

Cannabidiol-induced crosstalk of apoptosis and macroautophagy in colorectal cancer cells.Aug 04, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Discov. 2023 Aug 5 ;9(1):286. Epub 2023 Aug 5. PMID: 37542074
Article Published Date : Aug 04, 2023
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Heat Shock Protein Down-Regulation
[+]

Computational investigation of ginkgetin and theaflavin as potential inhibitors of heat shock protein 90.Dec 31, 2021

Pubmed Data : J Biomol Struct Dyn. 2022 ;40(24):13675-13681. Epub 2021 Oct 25. PMID: 34693877
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Ginkgo biloba, Theaflavins
Diseases : Cancers: All
Pharmacological Actions : Heat Shock Protein Down-Regulation
[+]

Curcumin enhanced the efficacy of anti-tumor drugs imatinib-mesylate and cytarabine through the inhibition of the tumor markers.Dec 31, 2013

Pubmed Data : J Environ Pathol Toxicol Oncol. 2014 ;33(3):247-63. PMID: 25272063
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Leukemia, Oxidative Stress
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cell cycle arrest, Heat Shock Protein Down-Regulation
Additional Keywords : Chemothapeutic Synergy: Cytarabine, Chemothapeutic Synergy: Imatinib
[+]

Essential oil from Cymbopogon flexuosus as the potential inhibitor for HSP90.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Rep. 2018 ;5:489-496. Epub 2018 Apr 5. PMID: 29854620
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lemongrass: Essential Oil
Diseases : Breast Cancer, Cancers: All
Pharmacological Actions : Chemotherapeutic, Heat Shock Protein Down-Regulation
Additional Keywords : Essential Oils
[+]

Gallic acid has an inhibitory effect on skin squamous cell carcinoma.Jan 29, 2023

Pubmed Data : Gene. 2023 Jan 30 ;851:147041. Epub 2022 Nov 12. PMID: 36375658
Article Published Date : Jan 29, 2023
Study Type : In Vitro Study
Additional Links
Substances : Gallic Acid
Diseases : Skin Cancer, Squamous cell carcinoma
Pharmacological Actions : Anti-metastatic, Heat Shock Protein Down-Regulation
[+]

Ginsenoside Rg1 could inhibit cerebral ischemia-induced nerve cell apoptosis.Jun 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2016 Jul ;11(7):1159-64. PMID: 27630703
Article Published Date : Jun 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Cerebral Ischemia, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Heat Shock Protein Down-Regulation, Neuroprotective Agents
Additional Keywords : Dose Response
[+]

Hesperetin induces apoptosis in A549 cells via the Hsp70‑mediated activation of Bax.Nov 30, 2022

Pubmed Data : Int J Oncol. 2022 Dec ;61(6). Epub 2022 Oct 5. PMID: 36196892
Article Published Date : Nov 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Hesperidin
Diseases : Lung Cancer
Pharmacological Actions : Apoptotic, Heat Shock Protein Down-Regulation
[+]

Luteolin can relieve the lesions and symptoms of psoriasis through reversing the effects of IFN-γ, inhibiting the expression and exosome secretion of HSP90.Jan 31, 2020

Pubmed Data : Int Immunopharmacol. 2020 Feb ;79:106070. Epub 2020 Jan 6. PMID: 31918062
Article Published Date : Jan 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Luteolin
Diseases : Psoriasis
Pharmacological Actions : Heat Shock Protein Down-Regulation, Immunomodulatory, Interferon Gamma Reducer
Additional Keywords : Exosomes
[+]

Resveratrol has chemotherapeutic potential in treating chronic myelogenous leukemia.Jan 01, 2010

Pubmed Data : PLoS One. 2010;5(1):e8719. Epub 2010 Jan 14. PMID: 20090934
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Heat Shock Protein Down-Regulation
Additional Keywords : Drug Synergy
[+]

Thermotherapy in combination with chemotherapy showed more strong inhibitory effect than those of thermotherapy or chemotherapy alone.Aug 31, 2008

Pubmed Data : Wei Sheng Yan Jiu. 2008 Sep ;37(5):529-32. PMID: 19069644
Article Published Date : Aug 31, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Lung Cancer
Therapeutic Actions : Heat Therapy
Pharmacological Actions : Heat Shock Protein Down-Regulation
Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Therapeutic Action Synergy with Drugs
[+]

This study reported that the pharmacogenomics of curcumin are similar to that of the antiviral drug, geldanamycin.Jun 21, 2015

Pubmed Data : Mol Med Rep. 2015 Jun 22. Epub 2015 Jun 22. PMID: 26100249
Article Published Date : Jun 21, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cytomegalovirus Infections
Pharmacological Actions : Antiviral Agents, Heat Shock Protein Down-Regulation
Additional Keywords : Natural Substances Versus Drugs
[+]

Ursolic acid and carvacrol may be potential inhibitors of dormancy protein small heat shock protein16.3 of Mycobacterium tuberculosis.Sep 30, 2018

Pubmed Data : J Biomol Struct Dyn. 2018 Oct ;36(13):3434-3443. Epub 2017 Oct 20. PMID: 28984500
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Ursolic Acid
Diseases : Mycobacterium Tuberculosis
Pharmacological Actions : Heat Shock Protein Down-Regulation

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