Heme oxygenase-1 up-regulation

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178 Substances Researched for Heme oxygenase-1 up-regulation
NameACCKFocus
Astaxanthin1625Locked
Curcumin1625Locked
Paeoniflorin814Locked
Pterostilbene814Locked
Crocin813Locked
Quercetin712Locked
Formononetin611Locked
Ginsenosides611Locked
Dandelion 610Locked
EGCG (Epigallocatechin gallate)610Locked
Luteolin610Locked
Omega-3 Fatty Acids110Locked
Pine Bark Extract110Locked
Sulforaphane810Locked
Astragaloside69Locked
Flavonoids58Locked
Hydrogen Water48Locked
Thymoquinone58Locked
Carnosic Acid27Locked
Crocetin47Locked
Melatonin67Locked
Piceatannol 57Locked
Polyphenols47Locked
Puerarin47Locked
Punicalagin37Locked
Apigenin46Locked
Ferulic acid46Locked
Fisetin56Locked
Fucoxanthin 46Locked
Garlic: Aged26Locked
Gastrodin46Locked
Grape Seed Extract36Locked
Hesperidin46Locked
Myricetin46Locked
Paeonol36Locked
Resveratrol46Locked
Rosemaric Acid46Locked
Seaweed: Brown 46Locked
Alpha-Lipoic Acid35Locked
Chokeberry15Locked
Coenzyme Q1035Locked
Sesamin15Locked
Wogonin35Locked
Berberine34Locked
Caffeic acid phenethyl ester24Locked
Chrysin24Locked
Dogwood24Locked
Eriodictyol44Locked
Genipin24Locked
Indole-3-Carbinol24Locked
Ligustrazine24Locked
Lotus 44Locked
Lutein24Locked
Lycopene34Locked
Mangiferin34Locked
Moringa oleifera34Locked
Naringenin 34Locked
Safflower34Locked
Tanshinone IIA34Locked
Vitamin C24Locked
6-Shogaol23Locked
Betulinic acid23Locked
Blue Honeysuckle23Locked
Butterbur23Locked
Diosmetin23Locked
Emodin23Locked
Fucoidan23Locked
Genistein23Locked
Ginkgo biloba23Locked
Ginseng23Locked
Ginseng (Korean)23Locked
Heme oxygenase-123Locked
Isoliquiritigenin23Locked
Isothiocyanates23Locked
Nigella sativa (aka Black Seed)23Locked
Perillaldehyde23Locked
Phellinus Linteus33Locked
Phlorotannins23Locked
Thymol23Locked
Vitexins23Locked
Zinc23Locked
Allicin12Locked
Alpha Linolenic Acid22Locked
Andrographolide12Locked
Anthocyanins22Locked
Arctigenin12Locked
Asiatic Acid12Locked
Bacopa12Locked
Bai Zhu12Locked
Biochanin A12Locked
Black Pepper12Locked
Buckwheat12Locked
Chaga Mushroom (Inonotus obliquus)12Locked
Cinnamaldehyde12Locked
Cinnamon12Locked
Dibenzoylmethane (DBM)12Locked
Eucalyptus12Locked
Geraniol 12Locked
Ginger12Locked
Gingerol 12Locked
Glycyrrhizin12Locked
Gotu Kola12Locked
Green Tea12Locked
Guduchi 12Locked
Gynostemma12Locked
Hawthorn12Locked
Hemp Seed12Locked
Jujube12Locked
Krill12Locked
Lactobacillus plantarum12Locked
Lavender12Locked
Lavender: Essential Oil12Locked
Magnolol12Locked
Medicinal Mushrooms12Locked
Nutmeg12Locked
Oligonol12Locked
Olive Oil12Locked
Olive leaf extract12Locked
Proanthocyanidins12Locked
Propolis: Bee12Locked
Pterocarpus marsupium12Locked
Radish22Locked
Raspberry12Locked
Rutin12Locked
Salvia miltiorrhiza12Locked
Selenium12Locked
Soursop22Locked
Strawberry12Locked
Tangeretin 22Locked
Theaflavins12Locked
Verbascoside12Locked
Xanthohumol12Locked
Yeast12Locked
Zeaxanthin12Locked
acetyl-11-keto-beta-boswellic acid12Locked
Apocynin11Locked
Avenanthramides11Locked
Bisdemethoxycurcumin11Locked
Black Currant11Locked
Blueberry11Locked
Burdock11Locked
Camel Milk 11Locked
Cashew11Locked
Chlorogenic Acid11Locked
Citric Acid 11Locked
Citrus Peel 11Locked
Elderberry11Locked
Ellagic Acid11Locked
Fermented Foods and Beverages11Locked
Glutathione11Locked
Hibiscus11Locked
Honeysuckle11Locked
Horseradish11Locked
Hydrangea11Locked
Kaempferol11Locked
Lemon Peel11Locked
Lignans11Locked
Lion's Mane (Hericium Erinaceus)11Locked
Maple11Locked
Milk Thistle11Locked
NAC (N-acetyl-L-cysteine)11Locked
Oats11Locked
Okra11Locked
Oleocanthal11Locked
Peony11Locked
Persimmon 11Locked
Phyllanthus amarus 11Locked
Piperlongumine 11Locked
Pomegranate11Locked
Poria cocos11Locked
Prickly Pear Cactus11Locked
Prunella vulgaris11Locked
Pycnogenol (Pine Bark)11Locked
Red Yeast Rice11Locked
Rock-rose11Locked
Royal Jelly11Locked
Sweet Potato: Purple11Locked
Wheat Germ11Locked

View the Evidence:
682 Abstracts with Heme oxygenase-1 up-regulation Research

[+]

Astaxanthin treatment has been shown to increase both serum TAC levels and activation of the Nrf2 axis in PCOS patients' GCs.Mar 02, 2022

Pubmed Data : J Assist Reprod Genet. 2022 Mar 3. Epub 2022 Mar 3. PMID: 35237893
Article Published Date : Mar 02, 2022
Study Type : Human Study
Additional Links
Substances : Astaxanthin
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1.Mar 31, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arterioscler Thromb Vasc Biol. 2008 Apr ;28(4):739-45. Epub 2008 Jan 17. PMID: 18202320
Article Published Date : Mar 31, 2008
Study Type : Human Study
Additional Links
Diseases : Endothelial Dysfunction, Hemodialysis, Inflammation
Therapeutic Actions : Thermal Therapy: Far-Infrared
Pharmacological Actions : Heme oxygenase-1 up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Omega-3 fatty acids decrease oxidative stress and inflammation in macrophages from patients with small abdominal aortic aneurysmSep 09, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Sep 10 ;9(1):12978. Epub 2019 Sep 10. PMID: 31506475
Article Published Date : Sep 09, 2019
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Aneurysm: Aortic
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pine bark extract significantly prolonged the lag time of LDL oxidation.Dec 31, 2014

Pubmed Data : Nutr Res. 2015 Jan ;35(1):56-64. Epub 2014 Oct 20. PMID: 25458248
Article Published Date : Dec 31, 2014
Study Type : Human Study, In Vitro Study
Additional Links
Substances : Pine Bark Extract
Diseases : Atherosclerosis, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation
Additional Keywords : Plant Extracts
[+]

Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS model.Jan 29, 2023

Pubmed Data : J Ethnopharmacol. 2023 Jan 30 ;301:115824. Epub 2022 Oct 20. PMID: 36273747
Article Published Date : Jan 29, 2023
Study Type : Human Study
Additional Links
Diseases : Inflammation, Insulin Resistance, Obesity, Polycystic Ovary Syndrome
Therapeutic Actions : Qigong
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression in human endothelial cells.Jan 31, 2016

Pubmed Data : Nutr Res. 2016 Feb ;36(2):143-9. Epub 2015 Oct 24. PMID: 26507778
Article Published Date : Jan 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Garlic: Aged
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Carnosic acid attenuates cartilage degeneration in human articular chondrocytes.Jul 04, 2018

Pubmed Data : Eur J Pharmacol. 2018 Jul 5 ;830:1-8. Epub 2018 Apr 17. PMID: 29678719
Article Published Date : Jul 04, 2018
Study Type : Human In Vitro
Additional Links
Substances : Carnosic Acid
Diseases : Osteoarthritis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Osteoprotective
[+]

Chokeberry extract may protect endothelial progenitor cells against angiotensin II-induced dysfunction.Dec 14, 2015

Pubmed Data : Phytomedicine. 2015 Dec 15 ;22(14):1238-46. Epub 2015 Nov 10. PMID: 26655406
Article Published Date : Dec 14, 2015
Study Type : Human In Vitro
Additional Links
Substances : Chokeberry
Diseases : Coronary Artery Disease, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Punicalagin protects human retinal pigment epithelium cells from ultraviolet radiation-induced oxidative damage.Jun 01, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2020 Jun 2 ;9(6). Epub 2020 Jun 2. PMID: 32498245
Article Published Date : Jun 01, 2020
Study Type : Human In Vitro
Additional Links
Substances : Punicalagin
Diseases : Eye Damage, Photooxidative Stress, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes.Dec 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Dec 13 ;7(50):83720-83726. PMID: 27863411
Article Published Date : Dec 12, 2016
Study Type : Human In Vitro
Additional Links
Substances : Sesamin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Nrf2 activation, Postaglandin PGE2 downregulation
[+]

Acetyl-11-keto-β-boswellic acid may serve as a promising treatment for age-related cataract progression.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:927871. Epub 2022 Jul 11. PMID: 35899124
Article Published Date : Dec 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Cataract, Hydrogen Peroxide Induced Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Andrographolide alleviated blood-brain barrier disruption, neuronal apoptosis, and oxidative stress in subarachnoid hemorrhage.Mar 18, 2022

Pubmed Data : Neurotox Res. 2022 Mar 19. Epub 2022 Mar 19. PMID: 35305248
Article Published Date : Mar 18, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Andrographolide
Diseases : Subarachnoid hemorrhage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Andrographolide inhibits static mechanical pressure-induced intervertebral disc degeneration.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2023 ;17:535-550. Epub 2023 Feb 20. PMID: 36845666
Article Published Date : Dec 31, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Degenerative Disk Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye.Apr 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eye Vis (Lond). 2023 May 1 ;10(1):17. Epub 2023 May 1. PMID: 37122017
Article Published Date : Apr 30, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gallic Acid
Diseases : Dry Eye Syndromes
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Baicalin improved hepatic injury of NASH by regulating NRF2/HO-1/NRLP3 pathway.Nov 04, 2022

Pubmed Data : Eur J Pharmacol. 2022 Nov 5 ;934:175270. Epub 2022 Sep 20. PMID: 36184988
Article Published Date : Nov 04, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids, Skullcap: Chinese
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Epicatechin gallate blocked cellular foam formation in atherosclerosis.Mar 05, 2023

Pubmed Data : Food Funct. 2023 Mar 6 ;14(5):2444-2458. Epub 2023 Mar 6. PMID: 36786689
Article Published Date : Mar 05, 2023
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Ginkgolide C slows the progression of osteoarthritis.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:1027553. Epub 2022 Oct 28. PMID: 36386227
Article Published Date : Dec 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Osteoarthritis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis.Sep 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Oct ;75:105819. Epub 2019 Aug 14. PMID: 31421546
Article Published Date : Sep 30, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginkgo biloba
Diseases : Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Remyelination
Additional Keywords : Remyelination
[+]

Protective effects of Lycium barbarum L. berry extracts against oxidative stress-induced damage of the retina of aging mouse and ARPE-19 cells.Dec 12, 2022

Pubmed Data : Food Funct. 2022 Dec 13. Epub 2022 Dec 13. PMID: 36512065
Article Published Date : Dec 12, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Goji
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Urolithin A attenuates ferroptosis in lipopolysaccharide-induced acute lung injury.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2023 ;14:1067402. Epub 2023 Mar 9. PMID: 36969874
Article Published Date : Dec 31, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model.May 26, 2020

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 May 27. Epub 2020 May 27. PMID: 32458011
Article Published Date : May 26, 2020
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Lung Injury: Acute, Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis Feb 22, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ecotoxicol Environ Saf. 2022 Feb 23 ;233:113339. Epub 2022 Feb 23. PMID: 35219255
Article Published Date : Feb 22, 2022
Study Type : Animal Study
Additional Links
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

The results suggested that the protective effects of Loganin on AKI during sepsis might be mediated by AKT and Nrf2/HO-1 pathway.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2021 ;15:501-513. Epub 2021 Feb 11. PMID: 33603340
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Dogwood
Diseases : Kidney Damage, Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

6-gingerol alleviates ferroptosis and inflammation of diabetic cardiomyopathy.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:3027514. Epub 2022 Dec 31. PMID: 36624878
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Cardiomyopathy, Diabetes: Cardiovascular Illness
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

6-Shogaol can alleviate allergic dermatitis-like skin lesions.Oct 31, 2016

Pubmed Data : Toxicol Appl Pharmacol. 2016 Nov 1 ;310:51-59. Epub 2016 Aug 22. PMID: 27562088
Article Published Date : Oct 31, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Dermatitis
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

6-Shogaol protects against ischemic acute kidney injury by modulating NFκB and heme oxygenase-1 pathways.Jul 16, 2019

Pubmed Data : Am J Physiol Renal Physiol. 2019 Jul 17. Epub 2019 Jul 17. PMID: 31313953
Article Published Date : Jul 16, 2019
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Renoprotective
[+]

6-Shogaol protects against isoproterenol-induced cardiac injury.Nov 30, 2022

Pubmed Data : J Physiol Pharmacol. 2022 Dec ;73(6). Epub 2023 Apr 17. PMID: 37087565
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence.May 31, 2020

Pubmed Data : Psychopharmacology (Berl). 2020 Jun ;237(6):1827-1840. Epub 2020 Mar 23. PMID: 32206827
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Diseases : Alcohol Toxicity , High Fat Diet, Memory Disorders, Oxidative Stress
Pharmacological Actions : Antioxidants, Brain-derived neurotrophic factor modulator, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Acacetin alleviates myocardial ischaemia/reperfusion injury.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2022 Dec ;60(1):553-561. PMID: 35244510
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Myocardial Ischemia, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Bcl-2 protein down-regulation, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Acacetin alleviates neuroinflammation and oxidative stress injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Neurosci. 2022 Jan 1 ;13(1):483-494. Epub 2022 Dec 21. PMID: 36590896
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Brain Inflammation , Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Neuroprotective Agents, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Acacetin attenuates mice endotoxin-induced acute lung injury via augmentation of heme oxygenase-1 activity.Mar 31, 2018

Pubmed Data : Inflammopharmacology. 2018 Apr ;26(2):635-643. Epub 2017 Oct 7. PMID: 28988328
Article Published Date : Mar 31, 2018
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Endotoxemia, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Açai berry mitigates Parkinson's disease progression showing dopaminergic neuroprotection.Sep 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Neurobiol. 2022 Oct ;59(10):6519-6533. Epub 2022 Aug 15. PMID: 35970975
Article Published Date : Sep 30, 2022
Study Type : Animal Study
Additional Links
Substances : Acai
Diseases : Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Acetyl-11-keto-beta boswellic acid can serve as an effective basis for developing a novel OCD treatment.Aug 04, 2023

Pubmed Data : Neurotoxicology. 2023 Aug 5 ;98:61-85. Epub 2023 Aug 5. PMID: 37549874
Article Published Date : Aug 04, 2023
Study Type : Animal Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Obsessive-Compulsive Disorder
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Acetyl-11-keto-beta-boswellic acid is a promising therapeutic agent to promote sciatic nerve repair by alleviating excessive oxidative stress.Aug 22, 2023

Pubmed Data : Planta Med. 2023 Aug 23. Epub 2023 Aug 23. PMID: 37541437
Article Published Date : Aug 22, 2023
Study Type : Animal Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Sciatic Nerve Crush Injury
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Nerve Regeneration
[+]

Acetyl-11-keto-β-boswellic acid ameliorates cognitive deficits and reduces amyloid-β levels.Mar 31, 2020

Pubmed Data : Free Radic Biol Med. 2020 Apr ;150:96-108. Epub 2020 Feb 25. PMID: 32109514
Article Published Date : Mar 31, 2020
Study Type : Animal Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Acetyl-11-keto-β-boswellic acid restores altered neurochemical levels, potentially preventing gross pathological abnormalities during MS progression.Jul 24, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genes (Basel). 2022 Jul 25 ;13(8). Epub 2022 Jul 25. PMID: 35893061
Article Published Date : Jul 24, 2022
Study Type : Animal Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Acteoside reduces HMGB1 release and may be beneficial for the treatment of sepsis.Mar 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Cells. 2013 Apr ;35(4):348-54. Epub 2013 Apr 4. PMID: 23563799
Article Published Date : Mar 31, 2013
Study Type : Animal Study
Additional Links
Substances : Verbascoside
Diseases : Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nitric Oxide Inhibitor, Nrf2 activation
[+]

Alleviative effects of astragaloside IV on cyclophosphamide-induced oxidative damage and immunosuppression.Nov 07, 2022

Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2022 Nov 8:109503. Epub 2022 Nov 8. PMID: 36368505
Article Published Date : Nov 07, 2022
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Immunomodulatory, Nrf2 activation
Problem Substances : Cyclophosphamide
[+]

Allicin ameliorates sepsis-induced acute kidney injury.Sep 04, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nat Med. 2023 Sep 5. Epub 2023 Sep 5. PMID: 37668824
Article Published Date : Sep 04, 2023
Study Type : Animal Study
Additional Links
Substances : Allicin
Diseases : Kidney Damage, Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Allicin has powerful protective effects against ischemia/hypoxia-induced cell apoptosis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:3207973. Epub 2018 Apr 16. PMID: 29849702
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Allicin
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Superoxide Dismutase Up-regulation
[+]

Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-κB pathways in traumatic brain injury.Jan 31, 2019

Pubmed Data : Mol Biol Rep. 2019 Feb ;46(1):241-250. Epub 2018 Nov 8. PMID: 30406889
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Isothiocyanates
Diseases : Brain: Oxidative Stress, Inflammation, Traumatic Brain Injury
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

Aloe polysaccharides ameliorate acute colitis.Jul 02, 2021

Pubmed Data : Int J Biol Macromol. 2021 Jul 3 ;185:804-812. Epub 2021 Jul 3. PMID: 34229016
Article Published Date : Jul 02, 2021
Study Type : Animal Study
Additional Links
Substances : Aloe Vera
Diseases : Colitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.Jan 20, 2021

Pubmed Data : Food Funct. 2021 Jan 21 ;12(2):696-705. Epub 2021 Jan 7. PMID: 33410857
Article Published Date : Jan 20, 2021
Study Type : Animal Study
Additional Links
Substances : Aloe Vera
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Aloin reduces HMGB1-mediated septic responses and improves survival in septic mice.Dec 31, 2018

Pubmed Data : Am J Chin Med. 2019 ;47(3):613-633. Epub 2019 Apr 9. PMID: 30966773
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Aloe Vera
Diseases : Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, SIRT1 Activator
Additional Keywords : Phytotherapy
[+]

Alpha-boswellic acid protects against ethanol-induced gastric injury.Mar 31, 2016

Pubmed Data : J Pharm Pharmacol. 2016 Apr ;68(4):514-22. Epub 2016 Mar 14. PMID: 26992040
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Frankincense
Diseases : Gastric Ulcer, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Anti-Ulcer Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Alpha-lipoic acid ameliorates doxorubicin-induced cognitive impairments.Jul 31, 2023

Pubmed Data : Neurochem Res. 2023 Aug ;48(8):2476-2489. Epub 2023 Apr 5. PMID: 37017891
Article Published Date : Jul 31, 2023
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation
[+]

Alpha-lipoic acid has ameliorative effects on the oxidative stress of a high fat diet. Aug 03, 2016

Pubmed Data : Free Radic Res. 2016 Aug 4:1-10. Epub 2016 Aug 4. PMID: 27383289
Article Published Date : Aug 03, 2016
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : High Fat Diet, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, NF-E2-Related Factor-2 (Nrf2) Modulator
[+]

Ameliorative effect of Ecklonia cava polyphenol extract on renal inflammation.May 16, 2017

Pubmed Data : J Agric Food Chem. 2017 May 17 ;65(19):3811-3818. Epub 2017 May 5. PMID: 28459555
Article Published Date : May 16, 2017
Study Type : Animal Study
Additional Links
Substances : Polyphenols, Seaweed: Brown
Diseases : Kidney Damage, Obesity, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Ameliorative impacts of Glycyrrhiza glabra root extract against nephrotoxicity induced by gentamicin in mice.Jun 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2021 Jul ;9(7):3405-3413. Epub 2021 May 22. PMID: 34262702
Article Published Date : Jun 30, 2021
Study Type : Animal Study
Additional Links
Substances : Licorice
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Renoprotective
[+]

Andrographolide alleviates paraquat-induced acute lung injury.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2023 ;26(6):653-661. PMID: 37275765
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Lung Injury: Acute, Pesticide Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Paraquat
[+]

Andrographolide contributes to spinal cord injury repair.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:949502. Epub 2022 Oct 7. PMID: 36278181
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Andrographolide protects against cigarette smoke-induced lung inflammation through activation of heme oxygenase-1.Apr 30, 2013

Pubmed Data : J Biochem Mol Toxicol. 2013 May ;27(5):259-65. Epub 2013 Apr 29. PMID: 23629921
Article Published Date : Apr 30, 2013
Study Type : Animal Study
Additional Links
Substances : Andrographolide
Diseases : Lung Injury: Smoke-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation
[+]

Anti-allergic rhinitis activity of α-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling.Jul 26, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2020 Jul 27 ;10(1):12528. Epub 2020 Jul 27. PMID: 32719431
Article Published Date : Jul 26, 2020
Study Type : Animal Study
Additional Links
Diseases : Allergic Rhinitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Immunomodulatory: Th17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antitumor activity of ferulic acid against Ehrlich solid carcinoma in rats via affecting hypoxia, oxidative stress and cell proliferation.Jun 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cureus. 2023 Jul ;15(7):e41985. Epub 2023 Jul 17. PMID: 37465088
Article Published Date : Jun 30, 2023
Study Type : Animal Study
Additional Links
Substances : Ferulic acid
Diseases : Ehrlich carcinoma
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Nrf2 activation
[+]

Apigenin has good hepatoprotective effects and potential as a promising therapeutic agent for acute liver failure in clinical application.Jan 10, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jan 11 ;68:171-178. Epub 2019 Jan 11. PMID: 30641432
Article Published Date : Jan 10, 2019
Study Type : Animal Study
Additional Links
Substances : Apigenin, Chrysin, Luteolin
Diseases : Liver Failure: Acute
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Malondialdehyde Down-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway.Aug 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Sep ;105:1283-1290. Epub 2018 Jun 22. PMID: 30021365
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Apigenin
Diseases : High Fructose Diet, Insulin Resistance, Metabolic Syndrome X
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Arctigenin exerts protective effects against myocardial infarction.Feb 28, 2018

Pubmed Data : Mol Med Rep. 2018 Mar ;17(3):4839-4845. Epub 2018 Jan 10. PMID: 29328478
Article Published Date : Feb 28, 2018
Study Type : Animal Study
Additional Links
Substances : Arctigenin
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Arctigenin, Myocardial Infarction
[+]

Asiatic acid attenuates pressure overload-induced cardiac fibrosis.Jun 25, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jun 26 ;74:105712. Epub 2019 Jun 26. PMID: 31254954
Article Published Date : Jun 25, 2019
Study Type : Animal Study
Additional Links
Substances : Asiatic Acid
Diseases : Hypertension, Myocardial Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astaxanthin alleviates inflammatory pain.Dec 12, 2021

Pubmed Data : Food Funct. 2021 Dec 13 ;12(24):12381-12394. Epub 2021 Dec 13. PMID: 34825683
Article Published Date : Dec 12, 2021
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astaxanthin ameliorated acetaminophen-induced liver injury.Sep 11, 2022

Pubmed Data : ACS Appl Mater Interfaces. 2022 Sep 12. Epub 2022 Sep 12. PMID: 36094079
Article Published Date : Sep 11, 2022
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Acetaminophen (Tylenol) Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen
[+]

Astaxanthin ameliorates the lipopolysaccharides-induced subfertility.Jun 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Dose Response. 2019 Jul-Sep;17(3):1559325819878537. Epub 2019 Sep 25. PMID: 31598118
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Infertility: Male, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Antioxidants, Fertility Agents: Male, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astaxanthin attenuates acute cerebral infarction via Nrf-2/HO-1 pathway in rats.Jan 17, 2021

Pubmed Data : Curr Res Transl Med. 2021 Jan 18 ;69(2):103271. Epub 2021 Jan 18. PMID: 33476935
Article Published Date : Jan 17, 2021
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Stroke
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Astaxanthin attenuates ferroptosis via Keap1-Nrf2/HO-1 signaling pathways in LPS-induced acute lung injury.Oct 13, 2022

Pubmed Data : Life Sci. 2022 Oct 14:121091. Epub 2022 Oct 14. PMID: 36252699
Article Published Date : Oct 13, 2022
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Lipid Peroxidation, Lipopolysaccharide-Induced Toxicity, Lung Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astaxanthin from haematococcus pluvialis ameliorates the chemotherapeutic drug doxorubicin induced liver injury. May 13, 2020

Pubmed Data : Food Funct. 2020 May 14. Epub 2020 May 14. PMID: 32405635
Article Published Date : May 13, 2020
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Astaxanthin prevents nephrotoxicity through Nrf2/ HO-1 pathway.Sep 07, 2023

Pubmed Data : Can J Physiol Pharmacol. 2023 Sep 8. Epub 2023 Sep 8. PMID: 37683291
Article Published Date : Sep 07, 2023
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Astaxanthin protects against early acute kidney injury in severely burned rats.Mar 22, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 Mar 23 ;11(1):6679. Epub 2021 Mar 23. PMID: 33758309
Article Published Date : Mar 22, 2021
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Burns, Kidney Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Renoprotective
[+]

Astaxanthin protects dendritic cells from lipopolysaccharide-induced immune dysfunction.Jun 16, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2021 Jun 17 ;19(6). Epub 2021 Jun 17. PMID: 34204220
Article Published Date : Jun 16, 2021
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Immunomodulatory, Nrf2 activation
[+]

Astaxanthin protects ochratoxin -induced lung injury in mice through the Nrf2/NF-κB pathway.Sep 16, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxins (Basel). 2019 Sep 17 ;11(9). Epub 2019 Sep 17. PMID: 31533259
Article Published Date : Sep 16, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Lung Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Astaxanthin provides neuroprotection in an experimental model of traumatic brain injury.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2021 ;13(3):1483-1493. Epub 2021 Mar 15. PMID: 33841672
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Astragalin reduces lipopolysaccharide-induced acute lung injury in rats via induction of heme oxygenase-1.Jul 31, 2019

Pubmed Data : Arch Pharm Res. 2019 Aug ;42(8):704-711. Epub 2019 Jun 27. PMID: 31250343
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV ameliorates preeclampsia-induced oxidative stress.Sep 13, 2020

Pubmed Data : Am J Physiol Endocrinol Metab. 2020 Sep 14. Epub 2020 Sep 14. PMID: 32924527
Article Published Date : Sep 13, 2020
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Oxidative Stress, Pre-Eclampsia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV attenuates myocardial ischemia-reperfusion injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:9137654. Epub 2019 Jun 24. PMID: 31341538
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:4625912. Epub 2019 Jun 11. PMID: 31285785
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Cardiac Hypertrophy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV inhibits AOM/DSS-induced colitis-associated tumorigenesis.Nov 30, 2023

Pubmed Data : Phytomedicine. 2023 Dec ;121:155116. Epub 2023 Sep 23. PMID: 37776619
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Colitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemopreventive, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV inhibits hepatocellular carcinoma by continually suppressing the development of fibrosis and regulating pSmad3C/3L and Nrf2/HO-1 pathways.Jun 18, 2021

Pubmed Data : J Ethnopharmacol. 2021 Jun 19 ;279:114350. Epub 2021 Jun 19. PMID: 34157326
Article Published Date : Jun 18, 2021
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Liver Cancer
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Chemopreventive, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Astragaloside IV protects against ischemia/reperfusion (I/R)-induced kidney injury based on the Keap1-Nrf2/ARE signaling pathway.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Androl Urol. 2022 Aug ;11(8):1177-1188. PMID: 36092836
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Atractylodes macrocephala or Taraxacum herba extracts can be considered natural agents that can prevent inflammatory bowel disease relapse.Sep 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Gut Liver. 2017 Sep 15 ;11(5):655-666. PMID: 28651306
Article Published Date : Sep 14, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Bai Zhu, Dandelion
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts, Risk Reduction, Superiority of Natural Substances versus Drugs
[+]

Attenuation of inflammatory pain by puerarin.Jul 31, 2018

Pubmed Data : Int Immunopharmacol. 2018 Aug ;61:306-316. Epub 2018 Jun 15. PMID: 29909234
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Bacopa monniera extract mitigates isoproterenol-induced cardiac stress.Nov 21, 2019

Pubmed Data : Arch Physiol Biochem. 2019 Nov 22:1-11. Epub 2019 Nov 22. PMID: 31755309
Article Published Date : Nov 21, 2019
Study Type : Animal Study
Additional Links
Substances : Bacopa
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Isoproterenol
[+]

Beneficial effects of Chrysin on Cadmium-induced nephrotoxicity.Jul 29, 2023

Pubmed Data : Gene. 2023 Jul 30 ;875:147502. Epub 2023 May 22. PMID: 37224935
Article Published Date : Jul 29, 2023
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Inflammation, Kidney Damage: Chemically-Induced, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, Renoprotective
Problem Substances : Cadmium
[+]

Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis in indomethacin-induced gastric injury.Jul 06, 2021

Pubmed Data : Food Funct. 2021 Jul 7 ;12(13):6001-6013. Epub 2021 May 26. PMID: 34037056
Article Published Date : Jul 06, 2021
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate
Diseases : Drug-Induced Toxicity: Indomethacin, Gastric Ulcer, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Ulcer Agents, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
Problem Substances : Indomethacin
[+]

Berberine can ameliorate tubulointerstitial fibrosis in diabetic nephropathy.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(8). Epub 2016 Aug 12. PMID: 27529235
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Diabetes Mellitus: Type 1, Diabetic Nephropathy, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Betanin prevents experimental abdominal aortic aneurysm progression.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2021 ;44(9):1254-1262. PMID: 34471054
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Betanin
Diseases : Aneurysm: Aortic
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity.Jul 26, 2019

Pubmed Data : Inflammopharmacology. 2019 Jul 27. Epub 2019 Jul 27. PMID: 31352642
Article Published Date : Jul 26, 2019
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Sepsis
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation, Vasodilator Agents
[+]

Betulinic acid mitigates zearalenone-induced liver injury.Jun 30, 2023

Pubmed Data : Food Chem Toxicol. 2023 Jul ;177:113811. Epub 2023 May 11. PMID: 37179046
Article Published Date : Jun 30, 2023
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Chemically-Induced Liver Damage, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Betulinic Acid Protects from Ischemia-Reperfusion Injury in the Mouse Retina Jan 15, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cells. 2021 09 16 ;10(9). Epub 2021 Sep 16. PMID: 34572088
Article Published Date : Jan 15, 2021
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Eye Damage, Ischemia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, MicroRNA modulator
[+]

Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury.Aug 31, 2016

Pubmed Data : Int Immunopharmacol. 2016 Sep ;38:324-31. Epub 2016 Jun 23. PMID: 27344638
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney.Dec 31, 2020

Pubmed Data : Int Immunopharmacol. 2021 Jan ;90:107117. Epub 2020 Nov 6. PMID: 33162346
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Bixin
Diseases : Kidney Damage: Chemically-Induced, Kidney Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective, Superoxide Dismutase Up-regulation
[+]

Broccoli seed extract was shown to reduce lipopolysaccharide-induced acute liver injury.Jul 20, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2023 Jul 21 ;12(14). Epub 2023 Jul 21. PMID: 37509878
Article Published Date : Jul 20, 2023
Study Type : Animal Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Lipopolysaccharide-Induced Toxicity, Liver Cancer
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

C60 fullerene prevents restraint stress-induced oxidative disorders.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:2518676. Epub 2018 Nov 13. PMID: 30538799
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Carbon 60
Diseases : Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Caffeic acid phenethyl ester could be considered as a promising neuroprotective agent against progressive neurodegenerative diseases.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Dis. 2018 Aug ;9(4):605-622. Epub 2018 Aug 1. PMID: 30090650
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2018 Jan ;22(1):101-110. Epub 2017 Dec 22. PMID: 29302217
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-10 upregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Caffeic acid phenethyl ester, Heme oxygenase-1 up-regulation, Ischemia
[+]

Cardamonin attenuates phorbol 12-myristate 13-acetate-induced pulmonary inflammation in alveolar macrophages.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Chem Toxicol. 2022 Jan ;159:112761. Epub 2021 Dec 8. PMID: 34890758
Article Published Date : Dec 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cardamonin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Cardio protective role of wogonin loaded nanoparticle against isoproterenol induced myocardial infarction.Nov 09, 2019

Pubmed Data : Colloids Surf B Biointerfaces. 2019 Nov 10:110635. Epub 2019 Nov 10. PMID: 31744760
Article Published Date : Nov 09, 2019
Study Type : Animal Study
Additional Links
Substances : Wogonin
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Carnosic acid ameliorates indomethacin-induced gastric ulceration.Mar 08, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2023 Mar 9 ;11(3). Epub 2023 Mar 9. PMID: 36979808
Article Published Date : Mar 08, 2023
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
Problem Substances : Indomethacin
[+]

Carnosic acid attenuates cadmium induced nephrotoxicity.Nov 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Nov 18 ;24(22). Epub 2019 Nov 18. PMID: 31752142
Article Published Date : Nov 17, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Kidney Damage: Chemically-Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
Problem Substances : Cadmium
[+]

Carnosic acid mitigates depression-like behavior in ovariectomized mice.Jan 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Neurobiol. 2023 Feb ;60(2):610-628. Epub 2022 Nov 4. PMID: 36331794
Article Published Date : Jan 31, 2023
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Diseases : Depression
Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Carvacrol mitigates vancomycin-induced nephrotoxicity.Nov 30, 2022

Pubmed Data : Eur Rev Med Pharmacol Sci. 2022 Dec ;26(23):8738-8755. PMID: 36524493
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Carvacrol
Diseases : Kidney Damage: Chemically-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, Renoprotective
Additional Keywords : Drug: Vancomycin
Problem Substances : Vancomycin
[+]

Celastrol treatment ameliorated acute ischemic stroke-induced brain injury.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2023 ;2023:1076522. Epub 2023 Apr 11. PMID: 37082194
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Celastrol
Diseases : Stroke: Ischemic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Centella asiatica extract prevents visual impairment by promoting the production of rhodopsin in the retina.May 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2020 Jun ;14(3):203-217. Epub 2020 Jan 28. PMID: 32528628
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Eye Diseases, Glaucoma, Macular Degeneration
Pharmacological Actions : Antioxidants, Cytoprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis.Aug 08, 2022

Pubmed Data : Int Immunopharmacol. 2022 Aug 9 ;111:109129. Epub 2022 Aug 9. PMID: 35961266
Article Published Date : Aug 08, 2022
Study Type : Animal Study
Additional Links
Substances : Chicoric Acid, Dandelion
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Chicoric acid prevents methotrexate hepatotoxicity.May 31, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2020 Jun ;27(17):20725-20735. Epub 2020 Apr 3. PMID: 32246423
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Chicoric Acid
Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Cinnamaldehyde ameliorates high-glucose-induced oxidative stress and cardiomyocyte injury.Jun 30, 2019

Pubmed Data : J Cardiovasc Pharmacol. 2019 Jul ;74(1):30-37. PMID: 31274840
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Cinnamaldehyde
Diseases : Cardiomyopathy, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:1583098. Epub 2017 Mar 15. PMID: 28396714
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Cinnamon
Diseases : High Fat Diet, Hyperlipidemia, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hypolipidemic, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Co-administration of geraniol with methotrexate may attenuate methotrexate-induced acute kidney injury.Oct 23, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Issues Mol Biol. 2021 Oct 24 ;43(3):1741-1755. Epub 2021 Oct 24. PMID: 34889889
Article Published Date : Oct 23, 2021
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Drug Toxicity: Methotrexate, Kidney Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
Problem Substances : Methotrexate
[+]

Coenzyme Q10 attenuated placental inflammatory and oxidative stress, thereby protecting against preeclampsia.Jul 21, 2020

Pubmed Data : Microcirculation. 2020 Jul 22:e12651. Epub 2020 Jul 22. PMID: 32697403
Article Published Date : Jul 21, 2020
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Pre-Eclampsia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Risk Reduction
[+]

Coenzyme Q10 has a coloprotective effect against experimentally induced ulcerative colitis.Jan 02, 2017

Pubmed Data : Inflammopharmacology. 2017 Jan 3. Epub 2017 Jan 3. PMID: 28050757
Article Published Date : Jan 02, 2017
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Glutathione Upregulation , Heme oxygenase-1 up-regulation, Malondialdehyde Down-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Coenzyme Q10, biochanin A, and phloretin counteracted the neurotoxic effect due to Cr(VI) exposure in scavenging of free radicals.Aug 11, 2022

Pubmed Data : Biol Trace Elem Res. 2022 Aug 12. Epub 2022 Aug 12. PMID: 35953644
Article Published Date : Aug 11, 2022
Study Type : Animal Study
Additional Links
Substances : Biochanin A, Coenzyme Q10, Phloretin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Cordyceps cicadae mycelia ameliorate cisplatin-induced acute kidney injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:7912763. Epub 2020 Feb 6. PMID: 32089779
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Medicinal Mushrooms
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Cordyceps militaris acidic polysaccharides improve learning and memory impairment.Dec 11, 2022

Pubmed Data : Int J Biol Macromol. 2022 Dec 12. Epub 2022 Dec 12. PMID: 36521708
Article Published Date : Dec 11, 2022
Study Type : Animal Study
Additional Links
Substances : Cordyceps Militaris
Diseases : Fatigue: Excercise-Induced
Therapeutic Actions : Exercise
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

Crocetin alleviates myocardial ischemia/reperfusion injury.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Feb ;21(2):641-648. Epub 2019 Dec 17. PMID: 31974615
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Crocetin suppresses uterine ischemia/reperfusion-induced inflammation and apoptosis through Nrf-2/HO-1 pathway.May 19, 2022

Pubmed Data : Curr Mol Med. 2022 May 20. Epub 2022 May 20. PMID: 35619323
Article Published Date : May 19, 2022
Study Type : Animal Study
Additional Links
Substances : Crocetin
Diseases : Inflammation, Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Crocetin was an effective agent in attenuating the adjuvant-induced arthritis rats in a concentration-dependent manner.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1341. Epub 2018 Dec 12. PMID: 30618728
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Crocetin
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Dose Response
[+]

Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis.Aug 25, 2019

Pubmed Data : Life Sci. 2019 Aug 26:116794. Epub 2019 Aug 26. PMID: 31465731
Article Published Date : Aug 25, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin exhibits an antihypertensive effect in a rat model of gestational hypertension and activates the Nrf-2/HO-1 signaling pathway.Jan 12, 2021

Pubmed Data : Hypertens Res. 2021 Jan 13. Epub 2021 Jan 13. PMID: 33442028
Article Published Date : Jan 12, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Gestational Hypertensive, Hypertension
Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Crocin has a role in attenuation of induced ulcerative colitis in rats.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:389-399. Epub 2018 Dec 5. PMID: 30530041
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Ulcerative Colitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation
[+]

Crocin improves the renal autophagy in rat experimental membranous nephropathy.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ren Fail. 2023 ;45(2):2253924. Epub 2023 Sep 19. PMID: 37724538
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Nephropathy
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective, SIRT1 Activator
[+]

Cryptotanshinone ameliorates hemorrhagic shock-induced liver injury.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Folia Histochem Cytobiol. 2023 ;61(2):109-122. PMID: 37435898
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Hemorrhagic Shock, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Cucurbitacin E glucoside alleviates concanavalin A-induced hepatitis.Jun 27, 2022

Pubmed Data : J Ethnopharmacol. 2022 Jun 28 ;292:115223. Epub 2022 Mar 27. PMID: 35354089
Article Published Date : Jun 27, 2022
Study Type : Animal Study
Additional Links
Substances : Cucurbitacin E
Diseases : Hepatitis: Lectin-Induced (concanavalin)
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, SIRT1 Activator
Problem Substances : Concanavalin A
[+]

Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity through heme oxygenase-1 induction.May 31, 2014

Pubmed Data : Otol Neurotol. 2014 Jun ;35(5):e169-77. PMID: 24608370
Article Published Date : May 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin, Heme oxygenase-1
Diseases : Ebola Virus Infections
Pharmacological Actions : Heme oxygenase-1 inducer, Heme oxygenase-1 up-regulation
[+]

Curcumin administration can limit the poisonous impacts of deltamethrin.Sep 30, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Oct ;33(10):e22386. Epub 2019 Aug 27. PMID: 31454128
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Pyrethroid Insecticide Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
Problem Substances : Deltamethrin
[+]

Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production.Dec 31, 2017

Pubmed Data : Clin Exp Pharmacol Physiol. 2018 Jan ;45(1):84-93. Epub 2017 Oct 3. PMID: 28853207
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Influenza A, Pneumonia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor
[+]

Curcumin exerts a protective effect on doxorubicin-induced nephrotic syndrome.Dec 23, 2019

Pubmed Data : J Ethnopharmacol. 2019 Dec 24 ;250:112502. Epub 2019 Dec 24. PMID: 31881321
Article Published Date : Dec 23, 2019
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Curcumin pretreatment is a promising adjuvant strategy for stem cells transplantation in myocardial restoration. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Stem Cells Int. 2015 ;2015:638153. Epub 2015 May 5. PMID: 26074974
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Ischemia: Myocardial, Oxidative Stress
Pharmacological Actions : Angiogenesis Inducing Agents, Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation
Additional Keywords : Mesenchymal Stem Cells
[+]

Curcumin protects against the age-related hearing loss.May 31, 2023

Pubmed Data : Biochem Pharmacol. 2023 Jun ;212:115575. Epub 2023 Apr 30. PMID: 37334787
Article Published Date : May 31, 2023
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Hearing Loss
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Curcumin restrains oxidative stress of after intracerebral hemorrhage.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:889226. Epub 2022 Apr 27. PMID: 35571134
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Intracerebral Hemorrhage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Cyanidin-3-galactoside from Aronia melanocarpa ameliorates silica-induced pulmonary fibrosis.Jul 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Food Sci Nutr. 2022 Aug ;10(8):2558-2567. Epub 2022 Mar 30. PMID: 35959254
Article Published Date : Jul 31, 2022
Study Type : Animal Study
Additional Links
Substances : Chokeberry, Cyanidin 3-glucoside
Diseases : Pulmonary Fibrosis, Silicosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Transforming growth factor beta (TGF-β) upregulation
[+]

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity.Jan 31, 2020

Pubmed Data : Chin J Nat Med. 2020 Feb ;18(2):103-113. PMID: 32172946
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Dandelion , Polyphenols
Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB.Aug 18, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Aug 19 ;142:111995. Epub 2021 Aug 19. PMID: 34435595
Article Published Date : Aug 18, 2021
Study Type : Animal Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Danshensu plus hydroxysafflor yellow A could achieve remarkable synergistic neuroprotective effects on ischemia-reperfusion injury.Dec 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2017 Dec 29 ;8(70):115434-115443. Epub 2017 Dec 15. PMID: 29383171
Article Published Date : Dec 28, 2017
Study Type : Animal Study
Additional Links
Substances : Safflower, Salvia miltiorrhiza
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Natural Substance Synergy
[+]

Dibenzoylmethane protects against carbon tetrachloride induced acute liver injury.Oct 31, 2017

Pubmed Data : AAPS J. 2017 Nov ;19(6):1703-1714. Epub 2017 Aug 21. PMID: 28828752
Article Published Date : Oct 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Dibenzoylmethane (DBM)
Diseases : Chemically-Induced Liver Damage, Liver Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Dieckol alleviates dextran sulfate sodium-induced colitis.Apr 30, 2021

Pubmed Data : Environ Toxicol. 2021 May ;36(5):782-788. Epub 2020 Dec 17. PMID: 33331035
Article Published Date : Apr 30, 2021
Study Type : Animal Study
Additional Links
Substances : Phlorotannins
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Dietary hydrolyzed jujube extract can reduce benzo(a)pyrene-induced lung inflammation.Jul 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2020 Aug 1 ;9(8). Epub 2020 Aug 1. PMID: 32752184
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : Jujube
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cytoprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Plant Extracts
Problem Substances : Benzo(a)pyrene
[+]

Dietary puerarin supplementation alleviates oxidative stress in the small intestines.Apr 06, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Animals (Basel). 2020 Apr 7 ;10(4). Epub 2020 Apr 7. PMID: 32272553
Article Published Date : Apr 06, 2020
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Diosmetin protects against ischemia/reperfusion-induced acute kidney injury.Jan 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Surg Res. 2017 06 15 ;214:69-78. Epub 2017 Mar 6. PMID: 28624062
Article Published Date : Jan 14, 2017
Study Type : Animal Study
Additional Links
Substances : Diosmetin
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Discovering the effects of fisetin on NF-κB/NLRP-3/NRF-2 molecular pathways in a mouse model of vascular dementia.Jun 18, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicines. 2022 Jun 19 ;10(6). Epub 2022 Jun 19. PMID: 35740470
Article Published Date : Jun 18, 2022
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Dementia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Echinacea purpurea polysaccharide prepared by fractional precipitation prevents alcoholic liver injury.Jul 19, 2021

Pubmed Data : Int J Biol Macromol. 2021 Jul 20 ;187:143-156. Epub 2021 Jul 20. PMID: 34293362
Article Published Date : Jul 19, 2021
Study Type : Animal Study
Additional Links
Substances : Echinacea
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Antioxidants, Gastroprotective, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

Echinacoside alleviates osteoarthritis in rats by activating the Nrf2-HO-1 signaling pathway.Jul 10, 2022

Pubmed Data : Immunopharmacol Immunotoxicol. 2022 Jul 11:1-10. Epub 2022 Jul 11. PMID: 35815581
Article Published Date : Jul 10, 2022
Study Type : Animal Study
Additional Links
Substances : Echinacea
Diseases : Osteoarthritis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Osteoprotective
[+]

Ecklonia cava ethanol extract has potential therapeutic effects for the alleviation of periodontal disease.May 21, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 May 22 ;11(5). Epub 2019 May 22. PMID: 31121899
Article Published Date : May 21, 2019
Study Type : Animal Study
Additional Links
Substances : Phlorotannins, Seaweed: Brown
Diseases : Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.Nov 30, 2019

Pubmed Data : J Bioenerg Biomembr. 2019 Dec ;51(6):393-402. Epub 2019 Nov 25. PMID: 31768722
Article Published Date : Nov 30, 2019
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Effects of epigallocatechin-3-gallate on oxidative stress, inflammation, and bone loss in a rat periodontitis model.Sep 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Dent Sci. 2023 Oct ;18(4):1567-1575. Epub 2023 Mar 11. PMID: 37799898
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Oxidative Stress, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia.Sep 03, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Cir Bras. 2020 Sep 4 ;35(8):e202000802. Epub 2020 Sep 4. PMID: 32901679
Article Published Date : Sep 03, 2020
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract, Proanthocyanidins
Diseases : Ischemia, Kidney Damage, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Proanthocyanidins
[+]

Effects of taraxasterol against ethanol and high-fat diet-induced liver injury.Nov 30, 2020

Pubmed Data : Life Sci. 2020 Dec 1 ;262:118546. Epub 2020 Oct 6. PMID: 33035580
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Dandelion
Diseases : Alcohol Toxicity , Alcoholic Liver Disease, High Fat Diet, Inflammation, Liver Damage, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

EGCG could be useful for the prevention and treatment of rheumatoid arthritis and other inflammatory disorders.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm (Lond). 2015 ;12:53. Epub 2015 Sep 15. PMID: 26379475
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate), Green Tea
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Immunomodulatory, NF-E2-Related Factor-2 (Nrf2) Modulator
[+]

EGCG decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice.Mar 07, 2016

Pubmed Data : J Leukoc Biol. 2016 Mar 8. Epub 2016 Mar 8. PMID: 26957211
Article Published Date : Mar 07, 2016
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Heme oxygenase-1 up-regulation, Immunomodulatory: Th17 downregulation, NF-E2-Related Factor-2 (Nrf2) Modulator, STAT3 Inhibitor
[+]

EGCG has an antiarthritic effect by regulating the oxidative-antioxidant balance and cytokine levels.Nov 18, 2019

Pubmed Data : Biotechnol Appl Biochem. 2019 Nov 19. Epub 2019 Nov 19. PMID: 31746064
Article Published Date : Nov 18, 2019
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Immunomodulatory: Th17 downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

EGCG may reduce atherosclerotic plaque and alleviate pathological damage in the cardiac tissue.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Contrast Media Mol Imaging. 2022 ;2022:8639139. Epub 2022 Jul 11. PMID: 35919501
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Coronary Artery Disease
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Electroacupuncture attenuates limb ischemia-reperfusion-induced lung injury.Dec 31, 2019

Pubmed Data : J Surg Res. 2020 02 ;246:170-181. Epub 2019 Oct 4. PMID: 31590030
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Liver Injury: Ischemia/reperfusion
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Electroacupuncture improves locomotor function by regulating expression of inflammation and oxidative stress-related proteins in mice with spinal cord injury.Nov 24, 2019

Pubmed Data : Zhen Ci Yan Jiu. 2019 Nov 25 ;44(11):781-6. PMID: 31777225
Article Published Date : Nov 24, 2019
Study Type : Animal Study
Additional Links
Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Electroacupuncture intervention may increase testosterone level of the aged rats.Aug 24, 2019

Pubmed Data : Zhen Ci Yan Jiu. 2019 Aug 25 ;44(8):566-70. PMID: 31475489
Article Published Date : Aug 24, 2019
Study Type : Animal Study
Additional Links
Diseases : Aging, Testosterone: Too Low
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Electroacupuncture relieves hippocampal injury by heme oxygenase-1 to improve mitochondrial function.Dec 31, 2021

Pubmed Data : J Surg Res. 2022 05 ;273:15-23. Epub 2022 Jan 10. PMID: 35016152
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Lipopolysaccharide-Induced Toxicity, Oxidative Stress, Sepsis
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation
[+]

Emodin protects against acute pancreatitis-associated lung injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2020 ;14:1971-1982. Epub 2020 May 21. PMID: 32546964
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Lung Injury: Acute, Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Emodin protects sepsis associated damage to the intestinal mucosal barrier through the VDR/ Nrf2 /HO-1 pathway.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:724511. Epub 2021 Dec 20. PMID: 34987380
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Emodin
Diseases : Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Evaluation of the hepatoprotective effects of curcumin and nanocurcumin against paraquat-induced liver injury.Feb 04, 2021

Pubmed Data : J Biochem Mol Toxicol. 2021 Feb 5:e22739. Epub 2021 Feb 5. PMID: 33544450
Article Published Date : Feb 04, 2021
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Pesticide Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Paraquat
[+]

Evaluation of the protective effect of olive leaf extract on cisplatin-induced testicular damage.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8487248. Epub 2018 Apr 26. PMID: 30013722
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Examining hepatoprotective effects of astaxanthin against methotrexate-induced hepatotoxicity.Jul 13, 2023

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2023 Jul 14. Epub 2023 Jul 14. PMID: 37450013
Article Published Date : Jul 13, 2023
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Drug Toxicity: Methotrexate, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Methotrexate
[+]

Farrerol alleviates hypoxic-ischemic encephalopathy by inhibiting ferroptosis.Aug 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Physiol Res. 2023 Aug 31 ;72(4):511-520. PMID: 37795893
Article Published Date : Aug 30, 2023
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Encephalopathy
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Fermented Aloe arborescens leaf extract suppresses acute alcoholic liver injury.Apr 27, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2023 Apr 28 ;33(4):463-470. Epub 2023 Jan 27. PMID: 36788475
Article Published Date : Apr 27, 2023
Study Type : Animal Study
Additional Links
Substances : Aloe Vera, Fermented Foods and Beverages
Diseases : Alcohol Toxicity , Alcoholic Liver Disease, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Ferulic acid exerts a protective effect against cyclosporine-induced liver injury.Sep 30, 2023

Pubmed Data : J Biochem Mol Toxicol. 2023 Oct ;37(10):e23427. Epub 2023 Jun 24. PMID: 37354073
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Substances : Ferulic acid
Diseases : Drug-Induced Toxicity: Cyclosporine
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Cyclosporine
[+]

Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats.Dec 30, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Dec 31. Epub 2019 Dec 31. PMID: 31889292
Article Published Date : Dec 30, 2019
Study Type : Animal Study
Additional Links
Substances : Ferulic acid
Diseases : Drug Toxicity: Methotrexate, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Methotrexate
[+]

Ferulic acid protects against methotrexate nephrotoxicity.Jul 31, 2019

Pubmed Data : Food Funct. 2019 Aug 1 ;10(8):4593-4607. Epub 2019 Jul 10. PMID: 31289794
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Ferulic acid
Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Fisetin alleviates liver damage, cell apoptosis, and oxidative stress induced by liver hepatic ischemia-reperfusion injury.Jan 31, 2021

Pubmed Data : Arch Med Res. 2021 Feb ;52(2):163-173. Epub 2020 Oct 21. PMID: 33645502
Article Published Date : Jan 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Fisetin ameliorates the inflammation and oxidative stress in lipopolysaccharide-induced endometritis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm Res. 2021 ;14:2963-2978. Epub 2021 Jul 5. PMID: 34262322
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Endometritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fisetin attenuates doxorubicin-induced cardiomyopathy.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:808480. Epub 2022 Feb 22. PMID: 35273493
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Cardioprotective, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Fisetin protects C2C12 mouse myoblasts from oxidative stress-induced cytotoxicity.May 27, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2023 May 28 ;33(5):591-599. Epub 2023 Jan 20. PMID: 36859395
Article Published Date : May 27, 2023
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Apoptotic, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Formononetin as a promising agent for preventing gentamicin-induced organ damage.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:916732. Epub 2022 May 26. PMID: 35712704
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Formononetin could improve the cognitive function by inhibiting neuroinflammation.Aug 06, 2019

Pubmed Data : CNS Neurol Disord Drug Targets. 2019 Aug 7. Epub 2019 Aug 7. PMID: 31389320
Article Published Date : Aug 06, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Alzheimer's Disease, Brain Inflammation , High Fat Diet
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Formononetin had the therapeutic effects in attenuating airway inflammation and oxidative stress in asthma.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:533841. Epub 2020 Sep 4. PMID: 33013383
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Asthma, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Formononetin protects against cisplatin‑induced acute kidney injury.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2020 Dec 1. Epub 2020 Dec 1. PMID: 33416097
Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Fucoidan inhibits lipopolysaccharide-induced acute lung injury.May 31, 2020

Pubmed Data : Arch Pharm Res. 2020 Jun ;43(6):646-654. Epub 2020 Jun 13. PMID: 32533502
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fucoidan reduces oxidative stress in alloxan-induced diabetic cardiomyopathy.Sep 03, 2023

Pubmed Data : Mol Biol Rep. 2023 Sep 4. Epub 2023 Sep 4. PMID: 37665545
Article Published Date : Sep 03, 2023
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Cardiomyopathy, Diabetic Complications
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Fucoxanthin attenuates oxidative damage by activating the Sirt1/Nrf2/HO-1 Signaling pathway to protect the kidney from ischemia-reperfusion injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:7444430. Epub 2022 Jan 28. PMID: 35126819
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Ischemia, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective, SIRT1 Activator
[+]

Fucoxanthin could be a novel adjuvant for preventing exacerbations associated with skin inflammation as well as protecting skin against UV radiation.Oct 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mar Drugs. 2018 Oct 10 ;16(10). Epub 2018 Oct 10. PMID: 30308980
Article Published Date : Oct 09, 2018
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Erythema, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Nrf2 activation, Photoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fucoxanthin could be exploited as a therapeutic target for protecting neurons from cerebral ischemic/reperfusion injury.Sep 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Oct ;106:1484-1489. Epub 2018 Jul 24. PMID: 30119223
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Cerebral Ischemia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetes.May 19, 2022

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2022 May 20 ;42(5):752-759. PMID: 35673921
Article Published Date : May 19, 2022
Study Type : Animal Study
Additional Links
Substances : Fucoxanthin
Diseases : Cardiomegaly, Myocardial Fibrosis
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation
Additional Keywords : Drug: Metformin
[+]

Galangin exhibits neuroprotective effects in 6-OHDA-induced models of Parkinson's disease.Aug 16, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Aug 17 ;15(8). Epub 2022 Aug 17. PMID: 36015161
Article Published Date : Aug 16, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Parkinson's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Galangin may represent a promising treatment for severe acute pancreatitis.Oct 07, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Oct 8 ;144:112293. Epub 2021 Oct 8. PMID: 34634559
Article Published Date : Oct 07, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Pancreatitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Gastrodin alleviates Tourette syndrome via Nrf-2/HO-1/HMGB1/NF-кB pathway.Aug 29, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Aug 30:e22389. Epub 2019 Aug 30. PMID: 31468582
Article Published Date : Aug 29, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Tourette Syndrome
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Gastrodin could be of importance for the treatment of Parkinson's disease.Aug 31, 2014

Pubmed Data : Neurochem Int. 2014 Sep ;75:79-88. Epub 2014 Jun 14. PMID: 24932697
Article Published Date : Aug 31, 2014
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Oxidative Stress, Parkinson's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Gastrodin pretreatment protects liver against ischemia-reperfusion injury.Dec 31, 2019

Pubmed Data : Am J Chin Med. 2020 ;48(5):1159-1178. PMID: 32668973
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Gastrodin
Diseases : Liver Injury: Ischemia/reperfusion , Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Additional Keywords : Phytotherapy
[+]

Genipin attenuates dextran sulfate sodium-induced colitis via suppressing inflammatory and oxidative responses.Oct 22, 2019

Pubmed Data : Inflammopharmacology. 2019 Oct 23. Epub 2019 Oct 23. PMID: 31646411
Article Published Date : Oct 22, 2019
Study Type : Animal Study
Additional Links
Substances : Genipin
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Genipin inhibited LPS-induced inflammatory response by activating Nrf2 signalling pathway in BV2 microglia.Sep 30, 2017

Pubmed Data : Neurochem Res. 2017 Oct ;42(10):2769-2776. Epub 2017 May 11. PMID: 28497344
Article Published Date : Sep 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Nrf2 activation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Genistein exerted antioxidant effects on myocardial injury in diabetic rats.Aug 27, 2019

Pubmed Data : Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019 Aug 28 ;44(8):850-856. PMID: 31570670
Article Published Date : Aug 27, 2019
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Diabetic Complications
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Genistein mitigates oxidative stress and inflammation by regulating Nrf2/HO-1 and NF-κB signaling pathways in hypoxic-ischemic brain damage.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2022 Jan ;10(2):32. PMID: 35282070
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Brain Ischemia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Geraniol protects against oxidative stress-induced apoptosis in hepatic ischemia-reperfusion injury.Sep 30, 2020

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2020 Oct ;393(10):1849-1858. Epub 2020 May 16. PMID: 32417955
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Substances : Geraniol
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginger extract ameliorates bisphenol A induced disruption in thyroid hormones synthesis and metabolism.Nov 02, 2019

Pubmed Data : Sci Total Environ. 2019 Nov 3:134664. Epub 2019 Nov 3. PMID: 31757552
Article Published Date : Nov 02, 2019
Study Type : Animal Study
Additional Links
Substances : Ginger
Diseases : Bisphenol Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Bisphenol A
[+]

Ginkgo biloba extract protected podocytes against hyperglycemia and prevented the development of diabetic nephropathy.Feb 09, 2021

Pubmed Data : J Ethnopharmacol. 2021 Feb 10 ;266:113474. Epub 2020 Oct 14. PMID: 33068650
Article Published Date : Feb 09, 2021
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy.Sep 30, 2023

Pubmed Data : J Tradit Chin Med. 2023 Oct ;43(5):906-914. PMID: 37679978
Article Published Date : Sep 30, 2023
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetes: Cardiovascular Illness
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ginsenoside Rb1 has beneficial effects on oxidative stress injury in rat spinal cords.Jul 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Aug ;16(2):1079-1086. Epub 2018 Jun 12. PMID: 30116359
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ginsenoside Rc attenuates myocardial ischaemic injury through antioxidative and anti-inflammatory effects.Nov 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2022 Dec ;60(1):1038-1046. PMID: 35634656
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Myocardial Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Metab Syndr Obes. 2019 ;12:1091-1103. Epub 2019 Jul 10. PMID: 31372019
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetes: Oxidative Stress, Diabetes Mellitus: Type 2, Diabetic Complications
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ginsenoside Rg1 inhibits oxidative stress and inflammation in rats with spinal cord injury.Jan 18, 2022

Pubmed Data : Neuroreport. 2022 01 19 ;33(2):81-89. PMID: 34954769
Article Published Date : Jan 18, 2022
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
[+]

Ginsenoside Rg1 may be a promising agent for prevention against acute liver injury.Jun 10, 2018

Pubmed Data : Int Immunopharmacol. 2018 Jun 11 ;61:266-276. Epub 2018 Jun 11. PMID: 29902710
Article Published Date : Jun 10, 2018
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetes. Jan 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Eur J Pharmacol. 2020 Jan 5 ;866:172801. Epub 2019 Nov 16. PMID: 31738935
Article Published Date : Jan 04, 2020
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Nrf2 activation
[+]

Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2/HO‑1‑mediated ferroptosis pathway.Jun 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2022 Jul ;50(1). Epub 2022 May 18. PMID: 35582998
Article Published Date : Jun 30, 2022
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Pancreatitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota.Jan 19, 2022

Pubmed Data : Food Funct. 2022 Jan 20. Epub 2022 Jan 20. PMID: 35048917
Article Published Date : Jan 19, 2022
Study Type : Animal Study
Additional Links
Substances : Medicinal Mushrooms
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Antioxidants, Gastrointestinal Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Gut-liver axis
[+]

Grape seed proanthocyanidin extract is a potential natural agent for the treatment of diabetic nephropathy.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:5205903. Epub 2020 Sep 29. PMID: 33062013
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis.Jan 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pathog Dis. 2013 Feb ;67(1):76-83. Epub 2012 Nov 15. PMID: 23620122
Article Published Date : Jan 31, 2013
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Atherosclerosis, Porphyromonas gingivalis
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, MicroRNA modulator
Additional Keywords : Gene Expression Regulation
[+]

Gypenoside attenuates renal ischemia/reperfusion injury in mice.Mar 31, 2016

Pubmed Data : Exp Ther Med. 2016 Apr ;11(4):1499-1505. Epub 2016 Jan 29. PMID: 27073472
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Gynostemma
Diseases : Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Renoprotective
[+]

Hawthorn extract could have protective effects in ovariectomized rats.May 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 May 13 ;8(5). Epub 2016 May 13. PMID: 27187458
Article Published Date : May 12, 2016
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Ovariectomy-Induced Changes, Plant Extracts
[+]

Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Nutr. 2022 ;9:936229. Epub 2022 Aug 3. PMID: 35990322
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Hyperlipidemia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Hepatoprotective effects of different extracts from triphala against CCl4-induced acute liver injury.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:664607. Epub 2021 Jul 5. PMID: 34290606
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Triphala
Diseases : Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : EXCLI J. 2019 ;18:723-745. Epub 2019 Aug 29. PMID: 31611754
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Pulmonary Fibrosis: Bleomycin-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

High dose of ascorbic acid may be useful in the treatment of sepsis, at least, by activation of Nrf2/HO-1 signals.Jun 14, 2015

Pubmed Data : Biochem Pharmacol. 2015 Jun 15 ;95(4):279-89. Epub 2015 Apr 17. PMID: 25896849
Article Published Date : Jun 14, 2015
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Significant Treatment Outcome
[+]

High-dose vitamin C alleviates pancreatic injury.Jun 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2020 Jul ;8(14):852. PMID: 32793696
Article Published Date : Jun 30, 2020
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Pancreatitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Pancreato Protective Agents
[+]

Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway.Jul 31, 2018

Pubmed Data : J Surg Res. 2018 Aug ;228:238-246. Epub 2018 Apr 11. PMID: 29907217
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Hydrogen-rich water protects against inflammatory bowel disease in mice.Feb 27, 2017

Pubmed Data : World J Gastroenterol. 2017 Feb 28 ;23(8):1375-1386. PMID: 28293084
Article Published Date : Feb 27, 2017
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Inflammatory Bowel Diseases, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis.Dec 31, 2020

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2021 04 1 ;320(4):G450-G463. Epub 2021 Jan 13. PMID: 33439102
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-10 upregulation
[+]

Hydroxysafflor yellow A attenuates allergic response of ovalbumin induced allergic rhinitis.Jun 30, 2023

Pubmed Data : Environ Toxicol. 2023 Jul ;38(7):1520-1534. Epub 2023 May 17. PMID: 37195255
Article Published Date : Jun 30, 2023
Study Type : Animal Study
Additional Links
Substances : Safflower
Diseases : Allergic Rhinitis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Hydroxysafflor yellow A improved retinopathy via Nrf2/HO-1 pathway.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Open Life Sci. 2022 ;17(1):284-292. Epub 2022 Mar 24. PMID: 35434371
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Safflower
Diseases : Diabetic Retinopathy
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Hydroxytyrosol acetate supplements might provide a basis for developing a new dietary strategy for the prevention of rheumatoid arthritis.Sep 17, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Sep 18. Epub 2015 Sep 18. PMID: 26382723
Article Published Date : Sep 17, 2015
Study Type : Animal Study
Additional Links
Substances : Olive Oil
Diseases : Oxidative Stress, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Hyperbaric oxygen has a neuroprotective role in traumatic brain injury.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genet Mol Res. 2016 ;15(1). Epub 2016 Jan 29. PMID: 26909929
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Diseases : Traumatic Brain Injury
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Anti-Apoptotic, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Hyperoside protected against oxidative stress-induced liver injury.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:1065. Epub 2020 Jul 17. PMID: 32765271
Article Published Date : Dec 31, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Liver Disease: Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Hypoglycemic effect of a novel polysaccharide from Lentinus edodes.Mar 06, 2022

Pubmed Data : Food Funct. 2022 Mar 7 ;13(5):3036-3049. Epub 2022 Mar 7. PMID: 35199807
Article Published Date : Mar 06, 2022
Study Type : Animal Study
Additional Links
Substances : Shiitake Mushroom
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hypoglycemic Agents, Nrf2 activation
Additional Keywords : Polysaccharides
[+]

Icariin improves erectile function in spontaneously hypertensive rats by up-regulating Nrf2.Jan 31, 2021

Pubmed Data : Zhonghua Nan Ke Xue. 2021 Feb ;27(2):106-113. PMID: 34914325
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Erectile Dysfunction, Hypertension
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:937502. Epub 2022 Sep 13. PMID: 36176424
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Icariin
Diseases : Degenerative Disk Disease
Pharmacological Actions : Antioxidants, Chondroprotective, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Improved anti-inflammatory effects of liposomal astaxanthin on a phthalic anhydride-induced atopic dermatitis model.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2020 ;11:565285. Epub 2020 Dec 1. PMID: 33335525
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Atopic Dermatitis
Pharmacological Actions : Antioxidants, Glutathione Peroxidase 1 (GPx1) Up-Regulation, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor
[+]

Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury.Dec 13, 2020

Pubmed Data : J Drug Target. 2020 Dec 14:1-11. Epub 2020 Dec 14. PMID: 33263461
Article Published Date : Dec 13, 2020
Study Type : Animal Study
Additional Links
Substances : Eucalyptus
Diseases : Endothelial Damage, Hyperglycemia
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Increased HO-1 expression, along with suppressed oxidative stress as well as reduced hepatic fat accumulation and fibrotic changes, contribute to the beneficial effects of curcumin.Sep 30, 2014

Pubmed Data : Can J Physiol Pharmacol. 2014 Oct ;92(10):805-12. Epub 2014 Aug 11. PMID: 25211173
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Fatty Liver, High Fat Diet, Metabolic Diseases
Pharmacological Actions : Heme oxygenase-1 up-regulation
[+]

Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2017 ;9(12):5653-5661. Epub 2017 Dec 15. PMID: 29312517
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Brain Injury: Traumatic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, MicroRNA modulator, Neuroprotective Agents
[+]

Indole-3-carbinol derivative DIM mitigates carbon tetrachloride-induced acute liver injury.Mar 16, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2020 Mar 17 ;21(6). Epub 2020 Mar 17. PMID: 32192079
Article Published Date : Mar 16, 2020
Study Type : Animal Study
Additional Links
Diseases : Liver Damage
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Indole-3-carbinol enhances the sensitivity of murine breast adenocarcinoma cells to doxorubicin.Jun 24, 2018

Pubmed Data : Chem Biol Interact. 2018 Jun 25 ;290:19-36. Epub 2018 May 15. PMID: 29775573
Article Published Date : Jun 24, 2018
Study Type : Animal Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Breast Cancer, Oxidative Stress
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Antioxidants, Apoptotic, Chemosensitizer, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Isorhamnetin alleviates airway inflammation by regulating the Nrf2/Keap1 pathway.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:860362. Epub 2022 Mar 24. PMID: 35401244
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Sea buckthorn
Diseases : Chronic Obstructive Pulmonary Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Ketogenic diet alleviates cognitive dysfunction and neuroinflammation.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neural Regen Res. 2023 Dec ;18(12):2767-2772. PMID: 37449643
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Diseases : Alzheimer's Disease, Brain Inflammation
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Krill oil might be a new candidate for treatment of iron overload-induced toxicity.Jan 31, 2020

Pubmed Data : Environ Sci Pollut Res Int. 2020 Feb ;27(4):3950-3961. Epub 2019 Dec 10. PMID: 31823254
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Krill
Diseases : Iron Overload, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Lactobacillus fermentum CQPC08 protects rats from lead-induced oxidative damage by regulating the Keap1/Nrf2/ARE pathway.Jul 04, 2021

Pubmed Data : Food Funct. 2021 Jul 5 ;12(13):6029-6044. PMID: 34037025
Article Published Date : Jul 04, 2021
Study Type : Animal Study
Additional Links
Substances : Lactobacillus fermentum
Diseases : Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
Problem Substances : Lead
[+]

Lactobacillus reuteri improves function of the intestinal barrier in rats with acute liver failure.Jun 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrition. 2022 Jul-Aug;99-100:111673. Epub 2022 Apr 1. PMID: 35567844
Article Published Date : Jun 30, 2022
Study Type : Animal Study
Additional Links
Substances : Lactobacillus reuteri
Diseases : Inflammation, Liver Failure: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation
[+]

Lactoferrin averts neurological and behavioral impairments of thioacetamide-induced hepatic encephalopathy.Sep 14, 2023

Pubmed Data : Neuropharmacology. 2023 Sep 15 ;236:109575. Epub 2023 May 16. PMID: 37201650
Article Published Date : Sep 14, 2023
Study Type : Animal Study
Additional Links
Substances : Lactoferrin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Laminaria japonica fucoidan ameliorates cyclophosphamide-induced liver and kidney injury.Oct 23, 2021

Pubmed Data : J Sci Food Agric. 2021 Oct 24. Epub 2021 Oct 24. PMID: 34689333
Article Published Date : Oct 23, 2021
Study Type : Animal Study
Additional Links
Substances : Fucoidan
Diseases : Chemically-Induced Liver Damage, Chemotherapy-Induced Toxicity: Cyclophosphamide, Kidney Damage: Chemically-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Cyclophosphamide
[+]

Lavender oil and especially linalool could be a potential agent for improving cognitive impairment in Alzheimer's disease.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:7426538. Epub 2017 Apr 26. PMID: 28529531
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Lavender, Lavender: Essential Oil
Diseases : Alzheimer's Disease, Cognitive Decline/Dysfunction
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Additional Keywords : Alzheimer's disease, Antioxidants, Cognitive Decline/Dysfunction, lavender, Lavender: Essential Oil
Problem Substances : Aluminum
[+]

Licochalcone B confers protective effects against LPS-Induced acute lung injury.Nov 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Rep. 2023 Dec ;28(1):2243423. PMID: 37565601
Article Published Date : Nov 30, 2023
Study Type : Animal Study
Additional Links
Substances : Licorice
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Linagliptin and indole-3-carbinol combination might represent a beneficial therapeutic modality for amelioration of polycystic ovarian syndrome.Jul 31, 2017

Pubmed Data : Chem Biol Interact. 2017 Aug 1 ;273:190-199. Epub 2017 Jun 13. PMID: 28619389
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Indole-3-Carbinol
Diseases : Polycystic Ovary Syndrome
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-10 downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lonicera caerulea L. polyphenols alleviate oxidative stress-induced intestinal environment imbalance and lipopolysaccharide-induced liver injury.Apr 05, 2020

Pubmed Data : Mol Nutr Food Res. 2020 Apr 6:e1901315. Epub 2020 Apr 6. PMID: 32250024
Article Published Date : Apr 05, 2020
Study Type : Animal Study
Additional Links
Substances : Blue Honeysuckle
Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Low-level laser therapy has an important anti-inflammatory action in acute lung inflammation.Sep 19, 2016

Pubmed Data : J Biophotonics. 2016 Sep 20. Epub 2016 Sep 20. PMID: 27649282
Article Published Date : Sep 19, 2016
Study Type : Animal Study
Additional Links
Diseases : Experimental Lung Inflammation
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation
[+]

Lutein and zeaxanthin isomers may attenuate photo-oxidative retinal damage.Aug 12, 2019

Pubmed Data : Biochem Biophys Res Commun. 2019 Aug 13 ;516(1):163-170. Epub 2019 Jun 13. PMID: 31204054
Article Published Date : Aug 12, 2019
Study Type : Animal Study
Additional Links
Substances : Lutein, Zeaxanthin
Diseases : Eye Damage, Photooxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lutein can alleviate oxidative stress, inflammation, and apoptosis induced by excessive alcohol to ameliorate reproductive damage.Jun 08, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2022 Jun 9 ;14(12). Epub 2022 Jun 9. PMID: 35745115
Article Published Date : Jun 08, 2022
Study Type : Animal Study
Additional Links
Substances : Lutein
Diseases : Alcohol Toxicity , Inflammation, Oxidative Stress, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Luteolin may suppress experimental colitis through the Nrf2 signaling pathway.Aug 24, 2016

Pubmed Data : Int Immunopharmacol. 2016 Aug 25 ;40:24-31. Epub 2016 Aug 25. PMID: 27569028
Article Published Date : Aug 24, 2016
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Luteolin protects against testicular injury induced by lead acetate.May 31, 2020

Pubmed Data : IUBMB Life. 2020 Jun 1. Epub 2020 Jun 1. PMID: 32478470
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Luteolin
Diseases : Lead Poisoning, Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Lead
[+]

Lycopene alleviates hepatic ischemia reperfusion injury.Mar 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2021 Apr ;9(8):631. PMID: 33987329
Article Published Date : Mar 31, 2021
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Lycopene ameliorates atrazine-induced spatial learning and memory impairments.Mar 31, 2023

Pubmed Data : Food Chem Toxicol. 2023 Apr ;174:113655. Epub 2023 Feb 13. PMID: 36791905
Article Published Date : Mar 31, 2023
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Memory Disorders, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway.Aug 15, 2018

Pubmed Data : Aging (Albany NY). 2018 Aug 16. Epub 2018 Aug 16. PMID: 30115814
Article Published Date : Aug 15, 2018
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Aging, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Lycopene exerts protective effects against Atrazine induced toxicity in rat adrenal cortex.Apr 21, 2016

Pubmed Data : Environ Sci Pollut Res Int. 2016 Apr 22. Epub 2016 Apr 22. PMID: 27102619
Article Published Date : Apr 21, 2016
Study Type : Animal Study
Additional Links
Diseases : Pesticide Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Problem Substances : Pesticides
[+]

Lycopene prevents phthalate-Induced cognitive impairment.Oct 22, 2023

Pubmed Data : J Agric Food Chem. 2023 Oct 23. Epub 2023 Oct 23. PMID: 37871231
Article Published Date : Oct 22, 2023
Study Type : Animal Study
Additional Links
Substances : Lycopene
Diseases : Phthalate Toxicity
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Problem Substances : Phthalates
[+]

Magnolol might be used as a potential treatment for alcoholic liver damage.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:1459. Epub 2019 Dec 5. PMID: 31920652
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Mangiferin alleviates arsenic induced oxidative lung injury.Feb 11, 2019

Pubmed Data : Food Chem Toxicol. 2019 Feb 12 ;126:41-55. Epub 2019 Feb 12. PMID: 30769048
Article Published Date : Feb 11, 2019
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Arsenic Poisoning
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Arsenic
[+]

Mangiferin mitigates di-(2-ethylhexyl) phthalate-induced testicular injury.Oct 29, 2021

Pubmed Data : Arch Biochem Biophys. 2021 Oct 30 ;711:108982. Epub 2021 Aug 13. PMID: 34400143
Article Published Date : Oct 29, 2021
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Phthalates
[+]

Manjari medika grape seed extract protects methotrexate-induced hepatic inflammation. Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Inflamm Res. 2023 ;16:467-492. Epub 2023 Feb 7. PMID: 36785716
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Inflammation, Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Maternal omega-3 fatty acid supplementation against prenatal lead exposure induced cognitive impairment in offspring mice.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Toxicol Sci. 2022 ;47(5):183-192. PMID: 35527006
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Cognitive Decline/Dysfunction, Lead Poisoning, Prenatal Chemical Exposures
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation
Problem Substances : Lead
[+]

Melatonin ameliorated sodium fluoride-induced testicular metabolic stress.Dec 10, 2019

Pubmed Data : Biol Trace Elem Res. 2019 Dec 11. Epub 2019 Dec 11. PMID: 31828722
Article Published Date : Dec 10, 2019
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
Problem Substances : Sodium Fluoride
[+]

Modulation of the TLR4/MyD88/NF- κ B pathway by Humulus japonicus extract protects against alcohol-induced liver injury.Dec 31, 2020

Pubmed Data : J Med Food. 2021 Jan ;24(1):18-27. Epub 2020 Dec 7. PMID: 33290158
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Hops
Diseases : Alcoholic Liver Disease, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Additional Keywords : Plant Extracts
[+]

Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy.Nov 15, 2021

Pubmed Data : Phytomedicine. 2021 Nov 16 ;95:153856. Epub 2021 Nov 16. PMID: 34856477
Article Published Date : Nov 15, 2021
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Diabetic Nephropathy
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Moringa oleifera protects SH-SY5YCells from DEHP-induced endoplasmic reticulum stress and apoptosis.Mar 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2021 Mar 29 ;10(4). Epub 2021 Mar 29. PMID: 33805396
Article Published Date : Mar 28, 2021
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Cognitive Decline/Dysfunction, Memory Disorders
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Myricetin may be a potential candidate for mitigating motor defects and demyelination.Oct 11, 2016

Pubmed Data : Food Funct. 2016 Oct 12 ;7(10):4332-4342. PMID: 27713953
Article Published Date : Oct 11, 2016
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Demyelinating Diseases
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Myristica fragrans kernels prevent paracetamol-induced hepatotoxicity.Feb 24, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Feb 25 ;20(4). Epub 2019 Feb 25. PMID: 30823534
Article Published Date : Feb 24, 2019
Study Type : Animal Study
Additional Links
Substances : Nutmeg
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Problem Substances : Acetaminophen, Paracetamol
[+]

Naringenin alleviates renal ischemia reperfusion injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:5992436. Epub 2022 Oct 10. PMID: 36262286
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Ischemia, Kidney Damage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Naringenin exerts anti-arthritic effects by downregulating NF-κB and activating the Nrf-2/HO-1 pathway.Sep 30, 2017

Pubmed Data : Pharmacol Rep. 2017 Oct ;69(5):1021-1029. Epub 2017 Apr 13. PMID: 28943290
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Arthritis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation
[+]

Naringenin protects against iron overload-induced osteoarthritis by suppressing oxidative stress.Sep 30, 2022

Pubmed Data : Phytomedicine. 2022 Oct ;105:154330. Epub 2022 Jul 14. PMID: 35905566
Article Published Date : Sep 30, 2022
Study Type : Animal Study
Additional Links
Substances : Naringenin
Diseases : Iron Overload, Osteoarthritis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Nrf2 activation
[+]

Naringin attenuates fructose-induced NAFLD progression.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:1049818. Epub 2022 Dec 15. PMID: 36588703
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity.May 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Environ Sci Pollut Res Int. 2022 Jun 1. Epub 2022 Jun 1. PMID: 35648353
Article Published Date : May 31, 2022
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Bisphenol Toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Bisphenol A
[+]

Nattokinase attenuates retinal neovascularization. May 02, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Invest Ophthalmol Vis Sci. 2021 May 3 ;62(6):25. PMID: 34036312
Article Published Date : May 02, 2021
Study Type : Animal Study
Additional Links
Substances : Nattokinase
Diseases : Corneal Neovascularization, Retinal Diseases
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Neuroprotective effect of ginsenoside Rb-1 on a rat model of Alzheimer's disease.Aug 17, 2020

Pubmed Data : Zhonghua Yi Xue Za Zhi. 2020 Aug 18 ;100(31):2462-2466. PMID: 32819064
Article Published Date : Aug 17, 2020
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Neuroprotective effects of erinacine A on an experimental model of traumatic optic neuropathy.Jan 11, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2023 Jan 12 ;24(2). Epub 2023 Jan 12. PMID: 36675019
Article Published Date : Jan 11, 2023
Study Type : Animal Study
Additional Links
Substances : Lion's Mane (Hericium Erinaceus)
Diseases : Optic Neuropathy
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neuroprotective effects of phytochemicals against aluminum chloride-induced Alzheimer's Disease.Aug 16, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Aug 17 ;15(8). Epub 2022 Aug 17. PMID: 36015156
Article Published Date : Aug 16, 2022
Study Type : Animal Study
Additional Links
Substances : Thymol, Thymoquinone
Diseases : Aluminum Toxicity , Alzheimer's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
Problem Substances : Aluminum Chloride
[+]

Neuroprotective effects of some nutraceuticals against manganese-induced parkinson's disease.Dec 13, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Dec 14 ;15(12). Epub 2022 Dec 14. PMID: 36559006
Article Published Date : Dec 13, 2022
Study Type : Animal Study
Additional Links
Substances : Coenzyme Q10, Sesamol, Thymol
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Neuroprotective role of chrysin-loaded poly(lactic-co-glycolic acid) nanoparticle against kindling-induced epilepsy.Sep 28, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 Sep 29:e22634. Epub 2020 Sep 29. PMID: 32991785
Article Published Date : Sep 28, 2020
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Brain: Oxidative Stress, Epilepsy
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Nigella sativa oil might be beneficial for controlling hypertension.Oct 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clinics (Sao Paulo). 2015 Nov ;70(11):751-7. PMID: 26602523
Article Published Date : Oct 31, 2015
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Hypertension
Pharmacological Actions : Antihypertensive Agents, Heme oxygenase-1 up-regulation
Additional Keywords : Natural Substances Versus Drugs
[+]

Notoginsenoside R1 alleviates spinal cord injury by inhibiting oxidative stress, neuronal apoptosis, and inflammation.Jan 02, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Neuroreport. 2022 08 3 ;33(11):451-462. Epub 2022 Jun 27. PMID: 35775321
Article Published Date : Jan 02, 2022
Study Type : Animal Study
Additional Links
Substances : Ginsenosides, Panax Notoginseng
Diseases : Inflammation, Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Notoginsenoside R1 alleviates spinal cord injury.Jun 27, 2022

Pubmed Data : Neuroreport. 2022 Jun 28 ;33(11). Epub 2022 Jun 28. PMID: 35776939
Article Published Date : Jun 27, 2022
Study Type : Animal Study
Additional Links
Substances : Ginsenosides, Panax Notoginseng
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Oligonol can be applied during maintenance therapy of inflammatory bowel disease to prevent relapse.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Physiol Pharmacol. 2018 Jun ;69(3). Epub 2018 Aug 22. PMID: 30149369
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Oligonol
Diseases : Inflammatory Bowel Diseases, Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Risk Reduction
[+]

Orange juice attenuated cardiac remodeling in infarcted rats and HO-1 may be play an important role in this process.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arq Bras Cardiol. 2021 06 ;116(6):1127-1136. PMID: 34133599
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Orange
Diseases : Myocardial Infarction
Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation
[+]

Pachymic acid ameliorates sepsis-induced acute kidney injury.Mar 31, 2017

Pubmed Data : Eur Rev Med Pharmacol Sci. 2017 Apr ;21(8):1924-1931. PMID: 28485784
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Poria cocos
Diseases : Inflammation, Kidney Damage, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage.Apr 02, 2020

Pubmed Data : Metab Brain Dis. 2020 Apr 3. Epub 2020 Apr 3. PMID: 32246322
Article Published Date : Apr 02, 2020
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Subarachnoid hemorrhage
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Paeoniflorin could effectively alleviate CCl4-induced hepatic fibrosis.Mar 05, 2021

Pubmed Data : J Pharm Pharmacol. 2021 Mar 6 ;73(3):338-346. PMID: 33793876
Article Published Date : Mar 05, 2021
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation
[+]

Paeoniflorin improves acute lung injury in sepsis.Aug 31, 2020

Pubmed Data : Sichuan Da Xue Xue Bao Yi Xue Ban. 2020 Sep ;51(5):664-669. PMID: 32975081
Article Published Date : Aug 31, 2020
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol alleviated acute alcohol-induced liver injury.May 31, 2018

Pubmed Data : Environ Toxicol Pharmacol. 2018 Jun ;60:110-117. Epub 2018 Apr 22. PMID: 29704732
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Alcoholic Liver Disease, Chemically-Induced Liver Damage, Lipid Peroxidation
Pharmacological Actions : Heme oxygenase-1 up-regulation, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation
[+]

Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways.Jan 14, 2017

Pubmed Data : Eur J Pharmacol. 2017 Jan 15 ;795:84-93. Epub 2016 Dec 6. PMID: 27940053
Article Published Date : Jan 14, 2017
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Epirubicin
Pharmacological Actions : Anti-Apoptotic, Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective
[+]

Paeonol attenuates hepatic ischemia/reperfusion injury.Aug 28, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2022 Aug 29 ;11(9). Epub 2022 Aug 29. PMID: 36139761
Article Published Date : Aug 28, 2022
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeonol pretreatment attenuates cerebral ischemic injury.Sep 30, 2014

Pubmed Data : Brain Res Bull. 2014 Oct ;109:61-7. Epub 2014 Oct 5. PMID: 25286445
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Paeonol
Diseases : Stroke: Ischemic
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Malondialdehyde Down-regulation, Neuroprotective Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury.Jan 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Transl Med. 2021 03 2 ;19(1):96. Epub 2021 Mar 2. PMID: 33653364
Article Published Date : Jan 01, 2021
Study Type : Animal Study
Additional Links
Substances : Ginseng
Diseases : Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Parthenolide phytosomes attenuated gentamicin-induced nephrotoxicity.Mar 16, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2023 Mar 17 ;28(6). Epub 2023 Mar 17. PMID: 36985711
Article Published Date : Mar 16, 2023
Study Type : Animal Study
Additional Links
Substances : Parthenolide
Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Gentamicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective, SIRT1 Activator
[+]

Peoniflorin activates Nrf2/ARE pathway to alleviate the Abeta(1-42)-induced hippocampal neuron injuryJul 31, 2013

Pubmed Data : Yao Xue Xue Bao. 2013 Aug ;48(8):1353-7. PMID: 24187848
Article Published Date : Jul 31, 2013
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Malondialdehyde Down-regulation, Nrf2 activation
[+]

Peptides from Antarctic krill ameliorate acute liver injury.Apr 23, 2023

Pubmed Data : Food Funct. 2023 Apr 24 ;14(8):3526-3537. Epub 2023 Apr 24. PMID: 37014333
Article Published Date : Apr 23, 2023
Study Type : Animal Study
Additional Links
Substances : Krill
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Perillaldehyde ameliorates aspergillus fumigatus keratitis.Jun 02, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Invest Ophthalmol Vis Sci. 2020 Jun 3 ;61(6):51. PMID: 32579678
Article Published Date : Jun 02, 2020
Study Type : Animal Study
Additional Links
Substances : Perillaldehyde
Diseases : Aspergillosis, Inflammation, Keratitis
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Phenethyl isothiocyanate attenuates diabetic nephropathy.Jun 28, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2021 Jun 29:111666. Epub 2021 Jun 29. PMID: 34215478
Article Published Date : Jun 28, 2021
Study Type : Animal Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Diabetic Nephropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Piceatannol attenuates testosterone-induced benign prostatic hyperplasia.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:614897. Epub 2020 Dec 21. PMID: 33519479
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Piceatannol
Diseases : Prostatic Hyperplasia: Benign
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Piceatannol protects rat neuron cells from oxygen-glucose deprivation reperfusion injury.Nov 24, 2022

Pubmed Data : Zhejiang Da Xue Xue Bao Yi Xue Ban. 2022 Nov 25 ;51(5):552-562. PMID: 36581571
Article Published Date : Nov 24, 2022
Study Type : Animal Study
Additional Links
Substances : Piceatannol
Diseases : Cerebral Ischemia, Oxidative Stress
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Piceatannol treatment results in significant protection against cadmium-induced testicular dysfunctions.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2019 ;13:2811-2824. Epub 2019 Aug 13. PMID: 31496657
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Piceatannol
Diseases : Testicular Injury: Chemical/Metal Induced
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
Problem Substances : Cadmium
[+]

Pinocembrin-7-methylether protects SH-SY5Y cells against 6-hydroxydopamine-induced neurotoxicity.Jul 31, 2021

Pubmed Data : Neurotox Res. 2021 Aug ;39(4):1323-1337. Epub 2021 May 17. PMID: 33999357
Article Published Date : Jul 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Parkinson's Disease
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation
[+]

Piper Nigrum extract improves OVA-induced nasal epithelial barrier dysfunction via activating Nrf2/HO-1 signaling.Dec 29, 2019

Pubmed Data : Cell Immunol. 2019 Dec 30:104035. Epub 2019 Dec 30. PMID: 32051090
Article Published Date : Dec 29, 2019
Study Type : Animal Study
Additional Links
Substances : Black Pepper
Diseases : Allergic Rhinitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation
[+]

Piperine improves experimental autoimmune encephalomyelitis.Aug 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Neurobiol. 2021 Aug 2. Epub 2021 Aug 2. PMID: 34338970
Article Published Date : Aug 01, 2021
Study Type : Animal Study
Additional Links
Diseases : Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Neuroprotective Agents, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Polysaccharides from hemp seed protect against cyclophosphamide-induced intestinal oxidative damage. Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:1813798. Epub 2020 Aug 25. PMID: 32908623
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Hemp Seed
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation
Additional Keywords : Polysaccharides
Problem Substances : Cyclophosphamide
[+]

Pomegranate peel has anti-inflammatory, antiapoptotic, free-radical-scavenging, and powerful antioxidant activity that protects against acrylamide toxicity.Jan 30, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Life (Basel). 2022 Jan 31 ;12(2). Epub 2022 Jan 31. PMID: 35207511
Article Published Date : Jan 30, 2022
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid, Pomegranate Peel
Diseases : Acrylamide-induced toxicity
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation
Problem Substances : Acrylamide
[+]

Pramipexole and Lactoferrin ameliorate Cyclophosphamide-Induced haemorrhagic cystitis.Oct 31, 2022

Pubmed Data : Int Immunopharmacol. 2022 Nov ;112:109282. Epub 2022 Oct 3. PMID: 36194984
Article Published Date : Oct 31, 2022
Study Type : Animal Study
Additional Links
Substances : Lactoferrin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis: Hemorrhagic, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pre-administration of hydrogen-rich water protects against lipopolysaccharide-induced sepsis and attenuates liver injury.Dec 31, 2016

Pubmed Data : Shock. 2017 07 ;48(1):85-93. PMID: 27918369
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Hydrogen Water
Diseases : Lipopolysaccharide-Induced Toxicity, Oxidative Stress, Sepsis
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pre-treatment with astaxanthin has a protective effect and is a safe therapeutic treatment for ischemia-reperfusion injury.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(11):e0187810. Epub 2017 Nov 9. PMID: 29121675
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Hypoxia, Liver Injury: Ischemia/reperfusion
Pharmacological Actions : Anti-Apoptotic, Bcl-2 protein down-regulation, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Preventive electroacupuncture alleviates oxidative stress and inflammation in rats with cyclophosphamide-induced premature ovarian Insufficiency.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2022 ;2022:6718592. Epub 2022 Aug 25. PMID: 36060148
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Inflammation, Oxidative Stress
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation
[+]

Protective effect of boswellic acids against doxorubicin-induced hepatotoxicity.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:8296451. Epub 2018 Feb 6. PMID: 29541348
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Frankincense
Diseases : Chemotherapy-Induced Toxicity: Doxorubicin, Liver Damage: Drug-Induced
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
Additional Keywords : Drug: Doxorubicin
[+]

Protective effect of crocin on liver function and survival in rats with traumatic hemorrhagic shock.Apr 30, 2021

Pubmed Data : J Surg Res. 2021 May ;261:301-309. Epub 2021 Jan 20. PMID: 33482612
Article Published Date : Apr 30, 2021
Study Type : Animal Study
Additional Links
Substances : Crocin
Diseases : Hemorrhagic Shock
Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization.Nov 14, 2021

Pubmed Data : Eur J Pharmacol. 2021 Nov 15 ;911:174522. Epub 2021 Sep 22. PMID: 34560076
Article Published Date : Nov 14, 2021
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
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Protective effect of fisetin on the lipopolysaccharide-induced preeclampsia.Dec 21, 2021

Pubmed Data : Hypertens Pregnancy. 2021 Dec 22:1-8. Epub 2021 Dec 22. PMID: 34933650
Article Published Date : Dec 21, 2021
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Lipopolysaccharide-Induced Toxicity, Pre-Eclampsia
Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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