Hepatoprotective

Name	AC	CK
Curcumin	179	467
Flavonoids	124	224
Ginsenosides	87	175
Vitamin C	46	143
Vitamin D	28	134
Vitamin E	25	124
Coffee	13	120
Berberine	65	118
NAC (N-acetyl-L-cysteine)	37	118
Silymarin	24	115
Resveratrol	50	111
Garlic	34	108
Silibinin	32	97
Green Tea	28	96
Melatonin	42	93
Nigella sativa (aka Black Seed)	31	91
Polyphenols	49	91
Thymoquinone	45	90
Peony	17	85
Quercetin	36	83
Licorice	27	82
Anthocyanins	32	75
Naringenin	37	74
Milk Thistle	20	71
Hydrogen Water	19	69
Astaxanthin	39	68
Lycopene	33	68
Turmeric	27	68
Alpha-Lipoic Acid	27	67
Hesperidin	27	65
Probiotics	21	64
Saffron	15	64
Fermented Foods and Beverages	28	63
Sulforaphane	32	63
Pomegranate	20	56
Chlorogenic Acid	22	55
Coenzyme Q10	20	55
Lactobacillus plantarum	24	55
Moringa oleifera	31	55
Flaxseed	11	54
Glycyrrhizin	19	53
Grape Seed Extract	19	53
Artichoke	14	52
Omega-3 Fatty Acids	14	52
Puerarin	28	51
Rose	23	51
Spirulina	22	51
Fucoidan	22	50
Astragaloside	18	49
Citrus naringin	28	49
Bee Propolis	12	48
Fenugreek	17	48
Royal Jelly	21	48
Blueberry	20	47
Ginger	23	45
Ginseng	19	45
Reishi Mushroom	20	45
Zinc	11	45
Hydroxytyrosol	14	44
Salvia miltiorrhiza	18	44
EGCG (Epigallocatechin gallate)	23	41
Chrysin	21	40
Ellagic Acid	21	40
Ginkgo biloba	24	40
Selenium	20	40
Tanshinone IIA	14	40
Chokeberry	16	38
Crocin	19	38
Goji	15	38
Dandelion	19	37
Luteolin	13	37
L-Carnitine	7	36
Magnesium	6	36
Paeoniflorin	20	36
Pterostilbene	21	36
Apigenin	19	35
Almond	4	34
Polyunsaturated Fatty Acids (PUFAs)	4	34
Ginseng (Korean)	10	33
Mangiferin	18	33
Fisetin	16	32
Bitter Melon	7	31
Lotus	18	31
DHA (Docosahexaenoic Acid)	7	30
Mulberry	18	30
Nobiletin	17	30
Rutin	16	30
Honeysuckle	17	29
Lactobacillus rhamnosus GG	15	29
Lignans	12	28
Piperine	11	28
Yoghurt	6	28
Guduchi	6	27
Olive Oil	10	27
Rosemary	14	27
Zataria multiflora	10	27
Black Tea	13	26
Apple Polyphenols	13	25
Artesunate	3	25
Blue Honeysuckle	13	25
Genistein	14	24
Honey	12	24
Honokiol	15	24
Sea buckthorn	12	24
Baicalein	12	23
Diosmin	12	23
Gingerol	12	23
Hawthorn	14	23
Paeonol	12	23
Piperidines	3	23
Ursolic Acid	12	23
Asiatic Acid	12	22
Betulinic acid	12	22
Chicory	7	22
Ferulic acid	11	22
Folic Acid	7	22
Hibiscus sabdariffa	7	22
Raspberry	11	22
Sesame Seed Oil	3	22
Artemisia princeps	1	21
Cannabidiol	11	21
Carvacrol	12	21
Catechin	8	21
Chlorella (Algae)	11	21
Lactobacillus fermentum	7	21
Lactobacillus salivarius	10	21
Rosmarinic acid	10	21
Sesamol	12	21
Walnut	11	21
Burdock	10	20
Chia	6	20
Cranberry	6	20
Diosgenin	11	20
Gallic Acid	11	20
Lutein	7	20
Nuts	2	20
Onion	6	20
Pomegranate Peel	6	20
Syringic Acid	10	20
Tea: Black	1	20
Tea: Green	1	20
Xanthohumol	11	20
Geraniol	9	19
Lactobacillus rhamnosus	5	19
Olive leaf extract	10	19
Vanillic Acid	10	19
Beet	9	18
Bilberry	5	18
Black Currant	5	18
Carotenoids	6	18
Cryptoxanthin	6	18
Garcinia kola	10	18
Kaempferol	10	18
Krill	9	18
Lactobacillus casei	5	18
Punicalagin	10	18
Shiitake Mushroom	5	18
Caffeic acid phenethyl ester	9	17
Echinacea	9	17
Fish Oil	5	17
Fucoxanthin	6	17
Garden Cress (Lepidium sativum)	7	17
Grape	9	17
Kombucha Tea	9	17
Myricetin	10	17
Poria cocos	10	17
Shikonin	9	17
Sweet Potato: Purple	9	17
Andrographis	10	16
Broccoli	4	16
Cordyceps Militaris	9	16
Curcumol	9	16
Radish	9	16
Strawberry	9	16
Aloe Vera	8	15
Cordyceps sinensis	6	15
Dates	8	15
Lactoferrin	8	15
Mangosteen	8	15
Organosulfur Compounds	11	15
Phlorotannins	9	15
Vitexins	8	15
Allicin	8	14
Astragalus	9	14
Lactobacillus helveticus	3	14
Panax Notoginseng	7	14
Papaya	7	14
Schisandra	8	14
Tetrahydrocurcumin	9	14
Turmeric: Fermented	3	14
White Tea	7	14
Diallyl sulfide	7	13
Eugenol	7	13
Fig	7	13
Folate	2	13
Frankincense	7	13
Jujube	7	13
Medicinal Mushrooms	7	13
Oleuropein	7	13
Plantago	3	13
Safflower	8	13
Amla Fruit	7	12
Andrographolide	8	12
Apocynin	6	12
Bifidobacterium Longum	6	12
Caffeic Acid	7	12
Camel Milk	6	12
Celery	6	12
Gastrodin	6	12
Holy Basil	2	12
Maitake Mushroom	6	12
Oolong tea	2	12
Phloretin	7	12
Raspberry ketone	6	12
Rice Bran	6	12
Rosemaric Acid	8	12
Taurine	6	12
Vitamin K2	2	12
Whey	6	12
beta-Carotene	2	12
Bromelain	5	11
Capsaicin	6	11
Chaga Mushroom (Inonotus obliquus)	8	11
Curcuminoids	2	11
Genipin	6	11
Indole-3-Carbinol	6	11
Isoliquiritigenin	6	11
Lemon Balm	6	11
Lychee	6	11
Purslane	7	11
Alpha-Carotene	1	10
Amino Acids	1	10
Ashwagandha	6	10
Bael	6	10
Bamboo	5	10
Barley	5	10
Beta Sitosterol	5	10
Biochanin A	6	10
Carnosic Acid	5	10
Egg	1	10
Garlic: Aged	5	10
Guava	6	10
Lactobacillus paracasei	5	10
Lingonberry	5	10
Litchi	5	10
Loquat	5	10
Menatetrenone	1	10
Multivitamin	1	10
Mululuza	6	10
Myo-inositol	1	10
Nattokinase	1	10
Noni	5	10
Nuts: All	1	10
Oleocanthal	1	10
Olive	5	10
Patchouli	5	10
Policosanol	5	10
Procyanidin B2	4	10
Propolis: Bee	5	10
Pumpkin Seeds	5	10
Seeds	1	10
Sesamin	5	10
Sumac	1	10
Thyme	5	10
Vitamin E: delta-tocopherol	1	10
Vitamin K2: Menaquinones (MK-4-14)	1	10
Zeaxanthin	1	10
Amygdalin	5	9
Antrodia camphorata	5	9
Apple	5	9
Babchi	5	9
Bee Venom	5	9
Beta-Caryophyllene	5	9
Cinnamon	5	9
Coconut Oil	4	9
Crocetin	5	9
Isothiocyanates	5	9
Kefir	5	9
Lactobacillus reuteri	5	9
Liquiritigenin	5	9
Nettle	5	9
Oyster Mushroom	5	9
Sage	5	9
Wheat Grass	5	9
Basil	4	8
Bee Pollen	4	8
Berries: All	4	8
Black Raspberry	4	8
Blackberry	5	8
Carbon 60	4	8
Carrot	4	8
Celastrol	5	8
Choline	4	8
Citrus Peel	5	8
Citrus Triterpenoids	4	8
Dill	4	8
Emodin	5	8
FOS (Fructooligosaccharides)	4	8
Fruit: All	5	8
Gotu Kola	5	8
Jambul	4	8
Lemon	4	8
Mucuna pruriens (aka Velvet Beans)	4	8
Orthosiphon	5	8
Piceatannol	4	8
Pomegranate Seed	4	8
Prickly Pear Cactus	5	8
Rhubarb	4	8
Scopoletin	5	8
Solanum nigrum (black nightshade)	4	8
Stevia	4	8
Stigmasterol	4	8
Tamarind	5	8
Tangeretin	6	8
Urolithin A	4	8
Xanthones	4	8
Yellow Tea	4	8
18β-Glycyrrhetinic Acid	3	7
6-Shogaol	4	7
Acai	4	7
Adlay	3	7
Arctigenin	4	7
Barberry	4	7
Berbamine	4	7
Betaine	4	7
Bixin	4	7
Chamomile	4	7
Eriodictyol	4	7
Gynostemma	5	7
Hops	4	7
Lupeol	4	7
Mugwort	5	7
Neem	4	7
Oleanolic acid	4	7
Oridonin	4	7
Palash	4	7
Sweet Potato	4	7
Thistle	5	7
Thymol	4	7
Vitamin B-12	3	7
Woodfordia fruticosa	4	7
Acacia catechu	3	6
Acorus calamus	4	6
Angelica	3	6
Apple Cider Vinegar	3	6
Ayurvedic formulation: Liv52	3	6
Bacopa	3	6
Banana	3	6
Betanin	3	6
Chicoric Acid	4	6
Coconut Water	3	6
Date Seeds	3	6
Dragon Fruit	3	6
EPA (Eicosapentaenoic Acid)	3	6
Horse Chestnut	3	6
Hu Zhang (Polygonum cuspidatum)	3	6
Juniper	3	6
Kiwifruit	3	6
Kudzu	4	6
Lactobacillus Acidophilus	3	6
Lactobacillus probiotics	3	6
Magnolol	3	6
Mango	3	6
Marjoram	3	6
Oregano	4	6
Parsley	3	6
Passion Flower	3	6
Phellinus Linteus	4	6
Phosphatidylcholine	3	6
Pumpkin Seed Oil/Meal	3	6
Pycnogenol (Pine Bark)	3	6
Saikosaponin	4	6
Seaweed	5	6
Shilajit	3	6
Sinomenine	3	6
Verbascoside	3	6
Wogonin	4	6
Zerumbone	3	6
acetyl-11-keto-beta-boswellic acid	3	6
Algae	3	5
Bifidobacterium animalis	3	5
Cannabinoids	3	5
Cocoa	3	5
Cucurbitacin B	3	5
Delphinidin	3	5
Formononetin	3	5
Harmine	3	5
Isoflavones	3	5
Lion's Mane (Hericium Erinaceus)	3	5
Nicotinamide Mononucleotide	3	5
Nicotinamide adenine dinucleotide (NADH)	3	5
Nutmeg	3	5
Okra	3	5
Oligosaccharides	3	5
Persimmon	3	5
Quince	3	5
Red Cabbage	3	5
Rooibos	3	5
Sesame Seeds	3	5
Skullcap: Chinese	2	5
Terminalia chebula	3	5
Theanine	2	5
Tomatidine	3	5
Toona sinensis	3	5
Vitamin E: alpha tocopherol	3	5
Watercress	3	5
Amaranth	2	4
Amygdalin (laetrile)	2	4
Anise	2	4
Baccharis trimera	2	4
Beeswax	2	4
Benzyl isothiocyanate	2	4
Bitter Apple	2	4
Bitter Orange	2	4
Boswellic Acid	2	4
Caffeine	2	4
Cannabis	2	4
Carnosine	2	4
Cashew	2	4
Cherry: All Varieties	2	4
Chrysanthemum Indicum	3	4
Cissus quadrangularis	2	4
Citicoline	2	4
Coffee: Green/Unroasted	2	4
Coriandrum sativum	2	4
Corn: Purple	2	4
Curcuma Comosa	2	4
D-Limonene	2	4
Dogwood	2	4
Embelia ribes	2	4
Feverfew	2	4
Flaxseed Oil	2	4
Geranium	2	4
Ginseng (American)	2	4
Green Coffee Bean	2	4
Guarana	2	4
Henna	2	4
Horehound	2	4
Icariin	2	4
Indian Gooseberry	2	4
Kimchi	2	4
Lauric acid	2	4
Ligustrazine	2	4
Long Pepper	2	4
Methionine	2	4
Myrrh	2	4
Oleic acid	2	4
Orange	2	4
Palmitoylethanolamide	2	4
Panax Ginseng	2	4
Pectin	2	4
Pine Nut	2	4
Potato	2	4
Pumpkin	2	4
Safranal	2	4
Seaweed: Brown	2	4
Silver (nanoparticles)	2	4
Soursop	2	4
Sweet Cherry	2	4
Syrian rue	2	4
Tannic Acid	2	4
Terminalia	2	4
Theaflavins	2	4
Tomato	2	4
Vanillin	2	4
Vitex negundo	2	4
White Mulberry	3	4
Yeast	2	4
Agaricus Blazei	2	3
Asparagus	2	3
Bergamot	2	3
Celery seed	2	3
Clove	2	3
Cucumber	2	3
Dong Quai	2	3
Glycyrrhiza uralensis	2	3
Huperzine	2	3
Leonurine	2	3
Lime: Key	1	3
Lingans	1	3
Motherwort	2	3
Mung Bean	2	3
Parthenolide	2	3
Phyllanthus urinaria	2	3
Pine Bark Extract	2	3
Pomelo	2	3
Prunella vulgaris	2	3
Water: Deep Sea	2	3
2-Methoxyestradiol	1	2
Acerola	1	2
Achiote	1	2
Ajwain	1	2
Apples	1	2
Apricot	1	2
Apricot Kernel	1	2
Arginine	1	2
Artemisinin	1	2
Avacado	1	2
Avocado	1	2
Banana Peel	1	2

[+]

Any form of intermittent fasting could be potentially beneficial for NAFLD treatment.Jan 18, 2024

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Pubmed Data : Curr Vasc Pharmacol. 2024 Jan 19. Epub 2024 Jan 19. PMID: 38321893

Article Published Date : Jan 18, 2024

Study Type : Meta Analysis, Review

Additional Links

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Fasting/Caloric Restriction

Pharmacological Actions : Hepatoprotective

[+]

Effects of artichoke supplementation on liver enzymes.Jun 30, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : PLoS One. 2015;10(11):e0142457. Epub 2015 Nov 10. PMID: 26556483

Article Published Date : Dec 31, 2014

Study Type : Meta Analysis

Additional Links

Substances : Coffee

Diseases : Liver Cirrhosis, Liver Fibrosis

Pharmacological Actions : Hepatoprotective

Additional Keywords : Risk Reduction

[+]

Coffee consumption could lower the risks of liver cancers, liver diseases and liver cirrhosis.Dec 31, 2015

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Pubmed Data : Drug Des Devel Ther. 2019 ;13:1969-1984. Epub 2019 Jun 17. PMID: 31354242

Pubmed Data : Semin Liver Dis. 2021 Jun 19. Epub 2021 Jun 19. PMID: 34147036

Article Published Date : Jun 18, 2021

Study Type : Meta Analysis

Additional Links

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Dietary Modification: Mediterranean Diet

Pharmacological Actions : Hepatoprotective

[+]

Physical activity reduces intrahepatic lipid content and markers of hepatocellular injury in patients with NAFLD.May 03, 2016

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Pubmed Data : Clin Gastroenterol Hepatol. 2016 May 4. Epub 2016 May 4. PMID: 27155553

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Eur J Gastroenterol Hepatol. 2016 Nov 7. Epub 2016 Aug 7. PMID: 27824642

[+]

A multivitamin and phospholipids complex protects the hepatic cells from androgenic-anabolic-steroids-induced toxicity.Jan 01, 2008

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Pubmed Data : Clin Toxicol (Phila). 2008 Jan;46(1):57-66. PMID: 17852158

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Multivitamin

Diseases : Androgen-Induced Diseases, Steroid-Induced Toxicity: Androgenic-Anabolic steroids

Pharmacological Actions : Hepatoprotective

[+]

A probiotic yogurt demonstrates a significant rate of minimal hepatic encephalopathy reversal. Jul 01, 2008

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Pubmed Data : Am J Gastroenterol. 2008 Jul;103(7):1707-15. PMID: 18691193

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Gastroenterology. 2018 Mar 28. Epub 2018 Mar 28. PMID: 29604292

Cranberry supplementation had a positive effect on some lipid profiles, insulin resistance, and hepatic steatosis in patients with NAFLD.Nov 18, 2021

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Pubmed Data : BMC Complement Med Ther. 2021 Nov 19 ;21(1):283. Epub 2021 Nov 19. PMID: 34798892

Article Published Date : Nov 18, 2021

Study Type : Human Study

Additional Links

Substances : Cranberry

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anticholesteremic Agents, Hepatoprotective, Hypolipidemic

[+]

Curcuma longa (turmeric) and tinospora cordifolia (guduchi) prevents antibiotic-induced liver damage in patients with tubercolosis. Aug 14, 2008

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Pubmed Data : World J Gastroenterol. 2008 Aug 14;14(30):4753-62.PMID:18720535

[+]

Diets with a higher intake of nuts may be associated with a decreased risk of NAFLD.Sep 03, 2019

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Pubmed Data : BMJ Open. 2019 Sep 4 ;9(9):e028961. Epub 2019 Sep 4. PMID: 31488477

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Pubmed Data : Nutrients. 2024 Feb 13 ;16(4). Epub 2024 Feb 13. PMID: 38398840

Article Published Date : Feb 12, 2024

Study Type : Human Study

Additional Links

Substances : Blueberry

Diseases : Prediabetes

Pharmacological Actions : Autophagy Inhibitors, Hepatoprotective, Hypolipidemic

[+]

Effect of branched-chain amino acid supplementation on functional liver regeneration in patients undergoing portal vein embolization and sequential hepatectomy.Nov 30, 2015

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Pubmed Data : J Gastroenterol. 2015 Dec ;50(12):1197-205. Epub 2015 Apr 8. PMID: 25847401

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Pubmed Data : Biomed Rep. 2020 Dec ;13(6):65. Epub 2020 Oct 20. PMID: 33149909

Article Published Date : Nov 30, 2020

Study Type : Human Study

Additional Links

Substances : L-Carnitine

Diseases : Liver Cirrhosis

Pharmacological Actions : Antioxidants, Hepatoprotective

[+]

Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury.Jan 28, 2021

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Pubmed Data : J Altern Complement Med. 2019 Oct 29. Epub 2019 Oct 29. PMID: 31657614

Article Published Date : Oct 28, 2019

Study Type : Human Study

Additional Links

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Electroacupuncture, Exercise: Aerobic

Pharmacological Actions : Hepatoprotective

[+]

Exercise in the management of metabolic-associated fatty liver disease. Sep 10, 2023

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Pubmed Data : Sports Med. 2023 Sep 11. Epub 2023 Sep 11. PMID: 37695493

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Adv Biomed Res. 2016 ;5:2. Epub 2016 Jan 27. PMID: 26955623

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Pubmed Data : Public Health Nutr. 2018 Apr 2:1-8. Epub 2018 Apr 2. PMID: 29607802

Article Published Date : Apr 01, 2018

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Nonalcoholic fatty liver disease (NAFLD), Prediabetes

Pharmacological Actions : Hepatoprotective

Additional Keywords : Risk Reduction

[+]

High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes.Dec 31, 2015

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Pubmed Data : J Nutr. 2021 Sep 15. Epub 2021 Sep 15. PMID: 34522969

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Pubmed Data : BMC Med. 2011 Jul 12 ;9:85. Epub 2011 Jul 12. PMID: 21749681

Pubmed Data : Nutrients. 2022 Sep 13 ;14(18). Epub 2022 Sep 13. PMID: 36145146

Article Published Date : Sep 12, 2022

Study Type : Human Study

Additional Links

Diseases : Nonalcoholic fatty liver disease (NAFLD), Obesity

Pharmacological Actions : Hepatoprotective

[+]

Melatonin ingestion prevents liver damage and improves biomarkers of renal function following a maximal exercise.Aug 31, 2023

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Pubmed Data : Res Q Exerc Sport. 2023 Sep ;94(3):869-879. Epub 2022 May 16. PMID: 35575746

Article Published Date : Aug 31, 2023

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Liver Damage

Therapeutic Actions : Exercise

Pharmacological Actions : Hepatoprotective

[+]

n-3 PUFA treatment is safe and efficacious in obese children with NAFLD and can improve ultrasonographic findings and the elevated transaminase levels.Jun 04, 2015

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[+]

Oral silymarin formulation efficacy in management of AC-T protocol induced hepatotoxicity in breast cancer patients.Apr 15, 2021

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Pubmed Data : J Oncol Pharm Pract. 2021 Apr 16:10781552211006182. Epub 2021 Apr 16. PMID: 33861657

Article Published Date : Apr 15, 2021

Study Type : Human Study

Additional Links

Substances : Silibinin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Doxorubicin, Chemotherapy-Induced Toxicity: Paclitaxel, Liver Damage: Drug-Induced

Pharmacological Actions : Chemoprotective Agents, Chemotherapeutic, Hepatoprotective

[+]

Pomegranate peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease.Aug 21, 2023

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Pubmed Data : Nutr J. 2023 Aug 22 ;22(1):40. Epub 2023 Aug 22. PMID: 37605174

Article Published Date : Aug 21, 2023

Study Type : Human Study

Additional Links

Substances : Pomegranate Peel

Diseases : Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anticholesteremic Agents, Antihypertensive Agents, Hepatoprotective, Hypolipidemic

Additional Keywords : Plant Extracts

[+]

Prevalence of Vitamin-D deficiency is related to severity of liver damage in Hepatitis-C patients.Feb 29, 2020

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Pubmed Data : Pak J Med Sci. 2020 Mar-Apr;36(3):445-450. PMID: 32292450

Article Published Date : Feb 29, 2020

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Pubmed Data : Food Funct. 2022 Nov 14 ;13(22):11568-11578. Epub 2022 Nov 14. PMID: 36263703

Article Published Date : Nov 13, 2022

Study Type : Human Study

Additional Links

Substances : Bee Propolis

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Dietary Modification: Low Calorie Diet

Pharmacological Actions : Hepatoprotective, Hypolipidemic

[+]

Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.Oct 31, 2017

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Supplementation with sulforaphane rich broccoli sprout extract could improve liver function through reduction of oxidative stress.Nov 20, 2015

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Pubmed Data : World J Gastroenterol. 2015 Nov 21 ;21(43):12457-67. PMID: 26604653

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Pubmed Data : Sci Rep. 2024 Jan 11 ;14(1):1053. Epub 2024 Jan 11. PMID: 38200253

Article Published Date : Jan 10, 2024

Study Type : Human Study

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Substances : Piperidines

Diseases : Liver Cirrhosis, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective, Hypoglycemic Agents

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The increased amount of coffee consumption lowers the incidence of fatty liver disease in Korean men.Jun 01, 2020

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Pubmed Data : Nutr Metab Cardiovasc Dis. 2020 Jun 2. Epub 2020 Jun 2. PMID: 32631703

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Pubmed Data : Nutrients. 2019 Dec 28 ;12(1). Epub 2019 Dec 28. PMID: 31905615

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Pubmed Data : Sci Rep. 2024 Jan 31 ;14(1):2592. Epub 2024 Jan 31. PMID: 38296998

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Pubmed Data : J Complement Integr Med. 2019 Jun 13 ;16(4). Epub 2019 Jun 13. PMID: 31199767

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Pubmed Data : Environ Toxicol. 2017 Feb ;32(2):630-644. Epub 2016 Mar 28. PMID: 28071871

Article Published Date : Jan 31, 2017

Study Type : Human In Vitro

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Substances : Mangiferin

Diseases : Chemically-Induced Liver Damage, Mercury Poisoning, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Antioxidants, Hepatoprotective

Additional Keywords : Methylmercury

Problem Substances : Mercury

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Procyanidin B2 alleviates palmitic acid-Induced injury in HepG2 cells.Dec 31, 2020

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Novel use of N-acetylcysteine in management of tyrosine kinase inhibitor induced acute liver injury.Nov 26, 2019

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Pubmed Data : Cureus. 2019 Nov 27 ;11(11):e6251. Epub 2019 Nov 27. PMID: 31890447

Article Published Date : Nov 26, 2019

Study Type : Human: Case Report

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Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen, Paracetamol

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Paeoniflorin ameliorates diabetic liver injury.Apr 24, 2022

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Pubmed Data : J Dairy Sci. 2024 Apr 10. Epub 2024 Apr 10. PMID: 38608952

Article Published Date : Apr 09, 2024

Study Type : Animal Study, In Vitro Study

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Substances : Lactoferrin

Diseases : Alcoholic Liver Disease, Iron Overload

Pharmacological Actions : Hepatoprotective

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Pubmed Data : Antioxidants (Basel). 2023 Mar 3 ;12(3). Epub 2023 Mar 3. PMID: 36978874

Article Published Date : Mar 02, 2023

Study Type : Animal Study, In Vitro Study

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Substances : Rosemary

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Hepatoprotective

Problem Substances : Acetaminophen

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Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride-induced liver damage.Dec 31, 2021

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Pubmed Data : Food Nutr Res. 2022 ;66. Epub 2022 Nov 18. PMID: 36590857

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

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Substances : Rosmarinic acid

Diseases : Chemically-Induced Liver Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Salvianolic acid A protects against acetaminophen-induced hepatotoxicity.Apr 02, 2023

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Pubmed Data : Antioxidants (Basel). 2023 Apr 3 ;12(4). Epub 2023 Apr 3. PMID: 37107244

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Pubmed Data : AMB Express. 2024 Mar 15 ;14(1):30. Epub 2024 Mar 15. PMID: 38491208

Article Published Date : Mar 14, 2024

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Lactobacillus rhamnosus

Diseases : Hangover

Pharmacological Actions : Hepatoprotective

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Synergistic therapy with celastrol-curcumin multifunctional nanomedicine: Anti-hepatocellular carcinoma and reduced hepatotoxicity.Feb 24, 2025

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Pubmed Data : Int J Pharm. 2025 Feb 25 ;671:125289. Epub 2025 Jan 27. PMID: 39880142

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Pubmed Data : Front Pharmacol. 2022 ;13:876550. Epub 2022 Apr 12. PMID: 35496312

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

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Substances : Quercetin

Diseases : High Fat Diet, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

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TFE3-mediated impairment of lysosomal biogenesis and defective autophagy contribute to fluoride-induced hepatotoxicity.Mar 14, 2023

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Pubmed Data : J Food Biochem. 2020 Jul 26:e13399. Epub 2020 Jul 26. PMID: 32713084

Article Published Date : Jul 25, 2020

Study Type : Animal Study

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Substances : Celery

Diseases : Acetaminophen (Tylenol) Toxicity , Liver Damage: Drug-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective

Problem Substances : Acetaminophen

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Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3 Aug 19, 2021

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Pubmed Data : Acta Pharmacol Sin. 2021 Aug 20. Epub 2021 Aug 20. PMID: 34417576

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Pubmed Data : An Acad Bras Cienc. 2020 ;92(2):e20191230. Epub 2020 Aug 10. PMID: 32785427

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Grape, Red Wine, Resveratrol

Diseases : High Fat Diet, Liver Damage

Pharmacological Actions : Hepatoprotective

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Epigallocatechin gallate but not catechin prevents nonalcoholic steatohepatitis in mice similar to green tea extract while differentially affecting the gut microbiota.Jun 19, 2020

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Pubmed Data : J Nutr Biochem. 2020 Jun 20 ;84:108455. Epub 2020 Jun 20. PMID: 32688217

Article Published Date : Jun 19, 2020

Study Type : Animal Study

Additional Links

Substances : EGCG (Epigallocatechin gallate)

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

[+]

F. religisoa protects against isoniazid, rifampicin and paracetamol induced oxidative liver injury in rats.Sep 30, 2013

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Pubmed Data : Pharmacognosy Res. 2013 Oct ;5(4):271-6. PMID: 24174821

Article Published Date : Sep 30, 2013

Study Type : Animal Study

Additional Links

Substances : Fig

Diseases : Liver Damage: Drug-Induced, Oxidative Stress

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

Problem Substances : Isoniazid, Paracetamol

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Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy Nov 09, 2021

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The hepatoprotective effect of prazosin is comparable to N- acetylcysteine against acetaminophen induced hepatotoxicity.Feb 29, 2020

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Pubmed Data : J Ayub Med Coll Abbottabad. 2020 Jan- Mar;32(1):28-32. PMID: 32468750

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Pubmed Data : Exp Ther Med. 2016 Jul ;12(1):369-376. Epub 2016 May 11. PMID: 27347064

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Ginger

Diseases : Hepatic Steatosis, Obesity

Pharmacological Actions : Hepatoprotective, Hypolipidemic

Additional Keywords : Anti-Obesity Agents

[+]

Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation.Nov 29, 2020

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Pubmed Data : Phytomedicine. 2020 Nov 30 ;81:153426. Epub 2020 Nov 30. PMID: 33341026

Article Published Date : Nov 29, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids , Cannabis

Diseases : Inflammation, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective

[+]

"Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats."Oct 01, 2006

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Pubmed Data : Mol Cell Biochem. 2006 Oct ;290(1-2):61-7. Epub 2006 Aug 26. PMID: 16937016

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : Vitamin E

Diseases : Chemically-Induced Liver Damage, Formaldehyde Toxicity, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

Problem Substances : Formaldehyde

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View the Evidence: 3874 Abstracts with Hepatoprotective Research

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Any form of intermittent fasting could be potentially beneficial for NAFLD treatment.Jan 18, 2024

Effects of artichoke supplementation on liver enzymes.Jun 30, 2022

Green tea intake had a significant lowering effect on the risk of developing liver cancer.Aug 28, 2022

Intermittent fasting improves hepatic end points in nonalcoholic fatty liver disease.Jul 31, 2023

Licorice and liver function in patients with primary liver disease.Aug 31, 2024

The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes.Nov 03, 2022

The effect of ginsenosides on liver injury.Dec 31, 2022

The effectiveness of curcumin, resveratrol, and silymarin on MASLD.Nov 30, 2024

The effects of pomegranate consumption on liver function enzymes in adults.Nov 28, 2023

The findings of this systematic review and meta-analysis support the potential effect of curcumin on the management of NAFLD.Dec 31, 2024

Therapeutic potential of artichoke in the treatment of fatty liver.Sep 30, 2022

Acupuncture may be effective and safe for treatment of NAFLD.Sep 23, 2021

Coffee consumption can significantly reduce the risk for hepatic fibrosis and cirrhosis.Dec 31, 2014

Coffee consumption could lower the risks of liver cancers, liver diseases and liver cirrhosis.Dec 31, 2015

Effect of Nigella sativa in the treatment of nonalcoholic fatty liver disease/Mar 15, 2021

Effect of saffron supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.Oct 11, 2021

Effects of garlic supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.Jul 31, 2020

Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.Dec 31, 2018

Evaluation of astragaloside IV in hepatic fibrosis: A meta-analysis. Apr 01, 2021

Green tea intake reduces the risk of liver disease.Dec 31, 2014

Impact of silymarin in individuals with nonalcoholic fatty liver disease.Dec 31, 2020

Influence of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease.Dec 26, 2024

Med-Diet is a beneficial pharmaconutritional therapy in patients with NAFLD. Jun 18, 2021

Physical activity reduces intrahepatic lipid content and markers of hepatocellular injury in patients with NAFLD.May 03, 2016

Polyunsaturated fatty acids supplementation can improve liver steatosis and liver functions.Dec 22, 2016

Prophylactic therapy of milk thistle on anti-tuberculosis drug-induced liver injury.Dec 31, 2018

Saffron supplementation can reduce ALT serum concentrations without significant effects on other liver function indicators.Mar 15, 2021

Silymarin can regulate energy metabolism, attenuate liver damage, and improve liver histology in NAFLD patients.Dec 31, 2023

Studies on coffee and NAFLD suggest that coffee consumption could have a protective role on fibrosis.Mar 29, 2016

Synergistic and hepatoprotective effect of total glucosides of paeony on ankylosing spondylitis.Dec 31, 2018

Tanshinone IIA can effectively improve liver fibrosis and liver function.Dec 31, 2018

The safety and efficacy of Momordica charantia L. in animal models of type 2 diabetes mellitus.Jan 31, 2021

These results found a significantly decreased risk of NAFLD among coffee drinkers and significantly decreased risk of liver fibrosis.Nov 06, 2016

This study determines the positive efficacy of vitamin D supplementation for chronic liver disease.Apr 30, 2020

Total glucosides of paeony adjuvant therapy might alleviate the incidence of hepatic adverse effect and leukopenia for the rheumatoid arthritis treatment.Mar 25, 2021

Vitamin E significantly improved liver function and histologic changes in patients with NAFLD/NASH.Jun 30, 2015

Vitamin E supplementation in the treatment on nonalcoholic fatty liver disease.Dec 31, 2022

8 weeks of provision of a diet low in free sugar content compared with usual diet resulted in significant improvement in hepatic steatosis.Jan 21, 2019

A 12-week supplement of purified anthocyanin improved insulin resistance, indicators of liver injury, and clinical evolution in NAFLD patients. Apr 30, 2015

A multivitamin and phospholipids complex protects the hepatic cells from androgenic-anabolic-steroids-induced toxicity.Jan 01, 2008

A probiotic yogurt demonstrates a significant rate of minimal hepatic encephalopathy reversal. Jul 01, 2008

A vitamin K2 preparation inhibits the development of liver cancer in patients with type C cirrhosis. Sep 01, 2010

Acetylcysteine for the treatment of suspected remdesivir-associated acute liver Failure in COVID-19.Oct 01, 2020

AGM possibly improves insulin sensitivity and β-cell function and reduces liver damage and inflammation in prediabetic adults.Jul 04, 2021

Almond protects the liver in coronary artery disease.Feb 28, 2021

Altilix supplementation was a beneficial approach in the management of hepatic and cardiometabolic alterations in metabolic syndrome subjects.Oct 24, 2019

An improved diet is particularly important for individuals with a high genetic risk for NAFLD.Mar 27, 2018

Antioxidant activity of hydroxytyrosol and vitamin E reduces systemic inflammation in children with paediatric NAFLD.Oct 11, 2020

Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing-remitting multiple sclerosis.May 01, 2021

Artichoke leaf extracts have benefits in the management of NASH.Dec 31, 2015

Association between dietary magnesium intake and liver fibrosis among type 2 diabetes mellitus patients.Jun 30, 2024

Association between serum vitamin D level and immune imbalance in advanced schistosomiasis patients with liver fibrosis.Feb 03, 2021

Beneficial effects of a novel fenugreek seed extract in women with polycystic ovary syndrome.Nov 27, 2022

Beneficial effects of curcumin supplementation were observed in decreasing disease activity scores and severity of cirrhosis in patients with cirrhosis.Feb 02, 2020

Beneficial effects of ketogenic diet in women with polycystic ovary syndrome and liver dysfunction who are obese.Feb 28, 2021

Beneficial effects of probiotic combination with omega-3 fatty acids in NAFLD.Nov 30, 2018

Beneficial effects of silybin treatment after viral eradication in patients with HCV.Dec 31, 2021

Beneficial shifts in gut microbiota by Lacticaseibacillus rhamnosus R0011 and Lactobacillus helveticus R0052 in alcoholic hepatitis.Jul 20, 2022

Biological effects of hydrogen water on subjects with NAFLD.Sep 27, 2022

Black cumin seeds decreased Methotrexate hepatotoxicity and improved survival in children with ALLMar 19, 2015

Chia-supplemented diet ameliorates non-alcoholic fatty liver disease and its metabolic abnormalities in humans.May 18, 2020

Clinical effectiveness of α-lipoic acid, myo-inositol and propolis supplementation on metabolic profiles and liver function in obese patients with NAFLD.Mar 31, 2023

Coffee consumption attenuates hepatic insulin resistance.Jan 31, 2014

Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechin-enriched green and oolong tea Jan 30, 2018

Compared with the hormone treatment, glycyrrhizic acid preparation might be a safe and effective treatment for autoimmune hepatitis.Jan 17, 2023

Consumption of hibiscus sabdariffa extracts reduced obesity, abdominal fat, serum FFA and improved liver steatosis.Mar 31, 2014

Cranberry supplementation had a positive effect on some lipid profiles, insulin resistance, and hepatic steatosis in patients with NAFLD.Nov 18, 2021

Curcuma longa (turmeric) and tinospora cordifolia (guduchi) prevents antibiotic-induced liver damage in patients with tubercolosis. Aug 14, 2008

Curcumin alleviates ethanol-induced oxidative damage in liver cells. Jan 18, 2010

Curcumin prevented the development of immunological alterations in NAFLD.Dec 31, 2016

Curcumin supplementation as a preventive strategy against tamoxifen-induced nonalcoholic fatty liver disease.Dec 31, 2024

curcumin supplementation can improve serum levels of inflammatory cytokines in subjects with NAFLD.Feb 29, 2020

Hepatoprotective

View the Evidence:
3874 Abstracts with Hepatoprotective Research