Histone deacetylase inhibitor

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52 Substances Researched for Histone deacetylase inhibitor
NameACCKFocus
Sulforaphane1627Locked
Curcumin1517Locked
Ginsenosides46Locked
Ketone Bodies45Locked
Thymoquinone15Locked
Butyrate34Locked
Genistein34Locked
Resveratrol33Locked
Astragaloside12Locked
Cucurbitacin B 12Locked
Curcumol12Locked
EGCG (Epigallocatechin gallate)22Locked
Gallic Acid12Locked
Polyphenols22Locked
Probiotics22Locked
Antineoplastons11Locked
Apples11Locked
Asafoetida11Locked
Astaxanthin11Locked
Avocado11Locked
Belamcanda chinensis 11Locked
Camptothecin11Locked
Catechin 11Locked
Charcone11Locked
Chrysin11Locked
Cruciferous Vegetables11Locked
Feijoa11Locked
Flavonoids11Locked
Formononetin11Locked
Ginger11Locked
Ginseng (Siberian)11Locked
Green Tea11Locked
Homeopathic Medicine: All11Locked
Indole-3-Carbinol11Locked
Isothiocyanates11Locked
Magnolia11Locked
Magnolol11Locked
Nigella sativa (aka Black Seed)11Locked
Oleuropein11Locked
Organosulfur Compounds11Locked
Parthenolide11Locked
Patchouli11Locked
Phenethyl isothiocyanate11Locked
Quercetin11Locked
Rose 11Locked
Spermidine 11Locked
Spirulina11Locked
Stilbenes11Locked
Theophylline11Locked
Thyme11Locked
Vitamin C11Locked
phytoestrogens11Locked

View the Evidence:
83 Abstracts with Histone deacetylase inhibitor Research

[+]

Rapid changes in histone deacetylases and inflammatory gene expression in expert meditatorsJan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Psychoneuroendocrinology. 2014 Feb ;40:96-107. Epub 2013 Nov 15. PMID: 24485481
Article Published Date : Jan 31, 2014
Study Type : Human Study
Additional Links
Diseases : Inflammation
Therapeutic Actions : Meditation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Histone deacetylase inhibitor
Additional Keywords : Gene Expression Regulation
[+]

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Pubmed Data : Exp Biol Med (Maywood). 2007 Feb;232(2):227-34. PMID: 17259330
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer, Prostate Cancer, Prostate Cancer: Prevention
Pharmacological Actions : Chemopreventive, Enzyme Inhibitors, Histone deacetylase inhibitor
[+]

Thymoquinone promotes pancreatic cancer cell death and reduction of tumor size.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Prev Med. 2016 ;2016:1407840. Epub 2016 Dec 26. PMID: 28105374
Article Published Date : Dec 31, 2015
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Thymoquinone
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Histone deacetylase inhibitor, P21 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Dose Response
[+]

Curcumin prevents neurodegeneration by blocking HDAC6-NLRP3 pathway-dependent neuroinflammation in Parkinson's disease.Jan 26, 2025

Pubmed Data : Int Immunopharmacol. 2025 Jan 27 ;146:113928. Epub 2024 Dec 25. PMID: 39724731
Article Published Date : Jan 26, 2025
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Brain Inflammation , Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Histone deacetylase inhibitor, Neuroprotective Agents
[+]

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain.Dec 27, 2020

Pubmed Data : Front Med. 2020 Dec 28. Epub 2020 Dec 28. PMID: 33369712
Article Published Date : Dec 27, 2020
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Brain Ischemia
Pharmacological Actions : Histone deacetylase inhibitor, Immunomodulatory
[+]

Curcumol controls choriocarcinoma stem-like cells self-renewal.Jan 23, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Jan 24 ;24:461-472. Epub 2018 Jan 24. PMID: 29363667
Article Published Date : Jan 23, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Choriocarcinoma
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : Cancer Stem Cells, Epigenetic Modification In Cancer
[+]

Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression.Sep 30, 2020

Pubmed Data : J Nutr Biochem. 2020 Oct ;84:108444. Epub 2020 Jun 2. PMID: 32615369
Article Published Date : Sep 30, 2020
Study Type : Animal Study
Additional Links
Substances : Gallic Acid
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor
[+]

Ginsenoside 20(s)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells.Dec 04, 2015

Pubmed Data : Chem Biol Interact. 2015 Dec 5 ;242:227-34. Epub 2015 Oct 19. PMID: 26482938
Article Published Date : Dec 04, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Leukemia
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor
[+]

Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(12):e115401. Epub 2014 Dec 18. PMID: 25521755
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Melanoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Histone deacetylase inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Ketone body β-hydroxybutyrate prevents myocardial oxidative stress in septic cardiomyopathy.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:2513837. Epub 2022 Mar 18. PMID: 35340211
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Ketone Bodies
Diseases : Cardiomyopathy, Lipopolysaccharide-Induced Toxicity, Oxidative Stress, Sepsis
Pharmacological Actions : Antioxidants, Cardioprotective, Histone deacetylase inhibitor
[+]

Sulforaphane attenuates cisplatin-induced hearing loss.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2021 ;35:20587384211034086. PMID: 34344210
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Histone deacetylase inhibitor
[+]

The effects of combinatorial genistein and sulforaphane in breast tumor inhibition: role in epigenetic regulation.Jun 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Jun 13 ;19(6). Epub 2018 Jun 13. PMID: 29899271
Article Published Date : Jun 12, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genistein, Sulforaphane
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antineoplastic Agents, Chemotherapeutic, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer, Natural Substance Synergy
[+]

This study is the first to show a beneficial effect of butyrate on muscle mass during aging.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Cell. 2015 Dec ;14(6):957-70. Epub 2015 Aug 20. PMID: 26290460
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Sarcopenia
Pharmacological Actions : Antioxidants, Histone deacetylase inhibitor
[+]

This study provides new insights into cucurbitacin B mediated epigenetic alterations and its chemotherapeutic effects on lung cancer.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2015 Jun ;8(6):552-62. Epub 2015 Mar 26. PMID: 25813524
Article Published Date : May 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer, Gene Expression Regulation, Reactivation Of Tumor Suppressor Gene
[+]

"EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity."Jun 30, 2012

Pubmed Data : Int J Mol Med. 2012 Jul ;30(1):69-74. Epub 2012 Apr 10. PMID: 22505206
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Histone deacetylase inhibitor
[+]

"Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases."Jun 30, 2012

Pubmed Data : Int J Oncol. 2012 Jul ;41(1):353-61. Epub 2012 Apr 26. PMID: 22552582
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Polyphenols
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Histone deacetylase inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Epigenetic Modification, Plant Extracts
[+]

21 hTERT down-regulation by HDAC1 inhibition is a promising approach for delaying or preventing colorectal cancer.Feb 04, 2017

Pubmed Data : Curr Cancer Drug Targets. 2017 Feb 5. Epub 2017 Feb 5. PMID: 28176652
Article Published Date : Feb 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Modification In Cancer
[+]

3,3'-Diindolylmethane inhibits histone deacetylase activity in prostate cancer cells.Sep 14, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Appl Pharmacol. 2012 Sep 15 ;263(3):345-51. Epub 2012 Jul 16. PMID: 22800507
Article Published Date : Sep 14, 2012
Study Type : In Vitro Study
Additional Links
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Histone deacetylase inhibitor, P21 Activation
[+]

A curcumin-based HDACs inhibitor for targeted sonodynamic therapy of breast cancer.Dec 31, 2024

Pubmed Data : Int J Biol Macromol. 2025 Jan ;287:138616. Epub 2024 Dec 11. PMID: 39672420
Article Published Date : Dec 31, 2024
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Histone deacetylase inhibitor
[+]

A. senticosus exhibited a potential for inhibition of histone deacetylase.May 31, 2016

Pubmed Data : Exp Hematol. 2016 Jun ;44(6):466-73. Epub 2016 Mar 15. PMID: 26992299
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (Siberian)
Diseases : Cancers: Drug Resistant, Leukemia, Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer, Plant Extracts
[+]

Anti-rheumatic activity of phenethyl isothiocyanate via inhibition of histone deacetylase-1.May 31, 2020

Pubmed Data : Chem Biol Interact. 2020 Jun 1 ;324:109095. Epub 2020 Apr 11. PMID: 32289289
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Apple may exert its protective effect against colorectal cancer through acting as a histone-deacetylase inhibitor. Apr 01, 2008

Pubmed Data : Nutrition. 2008 Apr;24(4):366-74. Epub 2008 Feb 11. PMID: 18262392
Article Published Date : Apr 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Apples
Diseases : Colorectal Cancer
Pharmacological Actions : Enzyme Inhibitors, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification, Plant Extracts
[+]

Astaxanthin reduced the protein expression of DNMT3b and significantly inhibited DNMT and HDAC activities in vitro.Dec 01, 2016

Pubmed Data : AAPS J. 2016 Dec 2. Epub 2016 Dec 2. PMID: 27913949
Article Published Date : Dec 01, 2016
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Prostate Cancer
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : DNA Methyltransferase, Epigenetic Modification In Cancer
[+]

Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases.Jun 04, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Jun 5 ;9(43):27280-27292. Epub 2018 Jun 5. PMID: 29930765
Article Published Date : Jun 04, 2018
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor
[+]

Butyrate induced apoptosis and inhibited cell proliferation via enhancing the intracellular expression of miR-22.Mar 06, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2017 Mar 7 ;12:340-349. Epub 2017 Mar 7. PMID: 28288414
Article Published Date : Mar 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Antiproliferative, Apoptotic, Butyrate, Histone deacetylase inhibitor, liver cancer, MicroRNA modulator
[+]

Chalcone and curcumin derivatives: a way ahead for malarial treatment.Nov 30, 2013

Pubmed Data : Mini Rev Med Chem. 2013 Dec ;13(14):2116-33. PMID: 24160709
Article Published Date : Nov 30, 2013
Study Type : Review
Additional Links
Substances : Charcone, Curcumin
Diseases : Malaria
Pharmacological Actions : Antimalarials, Histone deacetylase inhibitor
[+]

Chrysin as an emerging histone deacetylase inhibitor for prosperous epigenetic-based anticancer therapy.Sep 14, 2020

Pubmed Data : Phytother Res. 2020 Sep 15. Epub 2020 Sep 15. PMID: 32930436
Article Published Date : Sep 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Chrysin
Diseases : Cancers: All
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Condurango 30C appeared to trigger key epigenetic events of gene modulation in effectively combating cancer cells, which the placebo was unable to do.Nov 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2013 Dec ;16(4):7-13. PMID: 25780677
Article Published Date : Nov 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Histone deacetylase inhibitor, P21 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Epigenetic Modification In Cancer, Homeopathic Vs. Conventional Treatment, Low-Dose Pharmacology
[+]

Curcumin exhibits B-cell lymphoma cell proliferation.May 01, 2006

Pubmed Data : Ai Zheng. 2006 May;25(5):582-6. PMID: 16687078
Article Published Date : May 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Lymphoma: B-Cell
Pharmacological Actions : Anti-Proliferative, Antineoplastic Agents, Cell cycle arrest, Histone deacetylase inhibitor
[+]

Curcumin exhibits histone deacetylase inhibitor activity in malignant hematologic cells.Feb 01, 2009

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2009 Feb;29(1):25-8. Epub 2009 Feb 18. PMID: 19224157
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Hematologic Diseases
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Histone deacetylase inhibitor
[+]

Curcumin had an inhibitory effect on anchorage independent growth of HT29 cells at least in part by the epigenetic demethylation and up-regulation of DLEC1.Mar 14, 2015

Pubmed Data : Biochem Pharmacol. 2015 Mar 15 ;94(2):69-78. Epub 2015 Jan 29. PMID: 25640947
Article Published Date : Mar 14, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Chemotherapeutic, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification, Reactivation Of Tumor Suppressor Gene
[+]

Curcumin is a histone deacetylase inhibitor.Apr 15, 2005

Pubmed Data : Biochem Pharmacol. 2005 Apr 15;69(8):1205-13. PMID: 15794941
Article Published Date : Apr 15, 2005
Study Type : Review
Additional Links
Substances : Curcumin
Pharmacological Actions : Antineoplastic Agents, Histone deacetylase inhibitor
[+]

Curcumin is a natural pan-histone deacetylase inhibitor in cancer.Nov 13, 2017

Pubmed Data : Curr Pharm Des. 2017 Nov 14. Epub 2017 Nov 14. PMID: 29141538
Article Published Date : Nov 13, 2017
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Cancers: All
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Curcumin is an inhibitor of p300 histone acetylatransferase capable of blocking prostate cancer cells.Mar 01, 2006

Pubmed Data : Med Chem. 2006 Mar;2(2):169-74. PMID: 16787365
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Enzyme Inhibitors, Histone deacetylase inhibitor, Proteasome Inhibitors
[+]

Curcumin may have therapeutic value in HIV infection.Feb 19, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Feb 19. Epub 2010 Feb 19. PMID: 15383533
Article Published Date : Feb 19, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : HIV Infections
Pharmacological Actions : Antiproliferative , Apoptotic, Enzyme Inhibitors, Histone deacetylase inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-Cell lymphoma cell line proliferation.May 01, 2005

Pubmed Data : Acta Pharmacol Sin. 2005 May;26(5):603-9. PMID: 15842781
Article Published Date : May 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Lymphoma: B-Cell
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Histone deacetylase inhibitor
[+]

Diallyl trisulfides, a natural histone deacetylase inhibitor, attenuate HIF-1α synthesis, and decreases breast cancer metastasis.Jan 09, 2017

Pubmed Data : Mol Carcinog. 2017 10 ;56(10):2317-2331. Epub 2017 Jul 6. PMID: 28574600
Article Published Date : Jan 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Organosulfur Compounds
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Histone deacetylase inhibitor, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Diet, microbiota and gut microbial metabolites can modulate the progression of inflammatory diseases and autoimmunity.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Transl Immunology. 2016 May ;5(5):e82. Epub 2016 May 13. PMID: 27350881
Article Published Date : Apr 30, 2016
Study Type : Review
Additional Links
Substances : Probiotics
Diseases : Arthritis, Asthma, Autoimmune Diseases, Inflammation, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Histone deacetylase inhibitor
Additional Keywords : Dietary Modification, Microbiota
[+]

Dietary sulforaphane is a histone deacetylase inhibitor for cancer prevention.Dec 01, 2009

Pubmed Data : J Nutr. 2009 Dec;139(12):2393-6. Epub 2009 Oct 7. PMID: 19812222
Article Published Date : Dec 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Enzyme Inhibitors, Histone deacetylase inhibitor
[+]

Downregulation of HDAC3 by ginsenoside Rg3 inhibits epithelial-mesenchymal transition of cutaneous squamous cell carcinoma.Jun 12, 2019

Pubmed Data : J Cell Physiol. 2019 Jun 13. Epub 2019 Jun 13. PMID: 31192452
Article Published Date : Jun 12, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Squamous cell carcinoma
Pharmacological Actions : Anti-metastatic, Chemotherapeutic, Histone deacetylase inhibitor
[+]

Farnesiferol C induces apoptosis in chronic myelogenous leukemia cells as an imatinib sensitizer.Nov 05, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Nov 6 ;20(22). Epub 2019 Nov 6. PMID: 31698777
Article Published Date : Nov 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Asafoetida
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Chemosensitizer, Histone deacetylase inhibitor
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Feijoa apoptotic active principle is the Flavone and that this activity correlates with the induction of HDAC inhibitionDec 31, 2006

Pubmed Data : Int J Biochem Cell Biol. 2007 ;39(10):1902-14. Epub 2007 May 25. PMID: 17604209
Article Published Date : Dec 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : Feijoa
Diseases : Acute Myeloid Leukemia, Cancers: All
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Histone deacetylase inhibitor
Additional Keywords : Plant Extracts, Selective Cytotoxicity
[+]

Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(6):6434-41. Epub 2015 Jun 1. PMID: 26261519
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Chemosensitizer, Histone deacetylase inhibitor
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Ginsenoside Rh2 markedly inhibited the migration ability of HepG2 cells.Sep 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2014 Oct ;10(4):1779-85. Epub 2014 Jul 18. PMID: 25051397
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor
[+]

HDAC inhibition by Nigella sativa L. sprouts extract in hepatocellular carcinoma.Nov 09, 2023

Pubmed Data : J Biomol Struct Dyn. 2023 Nov 10:1-19. Epub 2023 Nov 10. PMID: 37948309
Article Published Date : Nov 09, 2023
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Liver Cancer
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : Natural Substances Versus Drugs
[+]

HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.Apr 05, 2018

Pubmed Data : Int J Cancer. 2018 Apr 6. Epub 2018 Apr 6. PMID: 29633255
Article Published Date : Apr 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Histone deacetylase modifications by probiotics in colorectal cancer.Dec 05, 2019

Pubmed Data : J Gastrointest Cancer. 2019 Dec 6. Epub 2019 Dec 6. PMID: 31808058
Article Published Date : Dec 05, 2019
Study Type : Review
Additional Links
Substances : Probiotics
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Histone deacetylase inhibitor
[+]

In this review, they discuss the biochemical and biological properties of sulforaphane with a particular emphasis on the anticancer properties of the dietary compound.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxid Redox Signal. 2015 Jun 1 ;22(16):1382-424. Epub 2014 Dec 19. PMID: 25364882
Article Published Date : May 31, 2015
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive, Histone deacetylase inhibitor, NF-kappaB Inhibitor, Phase II Detoxification Enzyme Inducer
Additional Keywords : Dietary Concentrations, Selective Cytotoxicity
[+]

Incorporation of an epigenetic diet may in fact be the key to chemoprevention.Jan 31, 2015

Pubmed Data : Curr Pharmacol Rep. 2015 Feb 1 ;1(1):46-51. PMID: 25774338
Article Published Date : Jan 31, 2015
Study Type : Review
Additional Links
Substances : Cruciferous Vegetables
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Diet, Epigenetic Modification
[+]

Magnolol and polyphenol mixture remarkably induced cell apoptosis by arresting the cell cycle in the G0/G1 phase.Jun 02, 2016

Pubmed Data : Pharmacol Res. 2016 Jun 3 ;111:113-125. Epub 2016 Jun 3. PMID: 27268146
Article Published Date : Jun 02, 2016
Study Type : In Vitro Study
Additional Links
Substances : Magnolia, Magnolol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor
[+]

Oleuropein has the potential to be a therapeutic drug for breast cancer prevention and treatment.May 21, 2019

Pubmed Data : J Cell Biochem. 2019 May 22. Epub 2019 May 22. PMID: 31119806
Article Published Date : May 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oleuropein
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive, Histone deacetylase inhibitor
[+]

PaDef a plant peptide triggers apoptosis, and induces global epigenetic modifications on histone 3 in an acute lymphoid leukemia cell line.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Mol Biosci. 2022 ;9:801816. Epub 2022 Jan 24. PMID: 35141282
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Avocado
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Apoptotic, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer
[+]

Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells.May 31, 2013

Pubmed Data : Int Immunopharmacol. 2013 Jun ;16(2):184-90. Epub 2013 Apr 17. PMID: 23602914
Article Published Date : May 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Patchouli
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Histone deacetylase inhibitor, NF-kappaB Inhibitor
[+]

Phytoestrogens regulate the proliferation and expression of stem cell factors in cell lines of malignant testicular germ cell tumors.Aug 19, 2013

Pubmed Data : Int J Oncol. 2013 Aug 20. Epub 2013 Aug 20. PMID: 23969837
Article Published Date : Aug 19, 2013
Study Type : In Vitro Study
Additional Links
Substances : Belamcanda chinensis , phytoestrogens
Diseases : Testicular Cancer Stem Cells
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor
[+]

Polyphenols from green tea inhibit the growth of melanoma cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genes Cancer. 2015 Jan ;6(1-2):49-61. PMID: 25821561
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Green Tea
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor
[+]

Quercetin induces human leukemia cell death via histone hyperacetylation.May 01, 2008

Pubmed Data : Pharmazie. 2008 May;63(5):379-83. PMID: 18557424
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Leukemia
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Review: curcumin may be an ideal epigenetic agent.Oct 15, 2010

Pubmed Data : Cancer. 2010 Oct 15;116(20):4670-6. PMID: 20597137
Article Published Date : Oct 15, 2010
Study Type : Review
Additional Links
Substances : Curcumin
Pharmacological Actions : Antineoplastic Agents, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification
[+]

Review: The present state of antineoplaston research (1)Mar 01, 2004

Pubmed Data : Integr Cancer Ther. 2004 Mar ;3(1):47-58. PMID: 15035876
Article Published Date : Mar 01, 2004
Study Type : Review
Additional Links
Substances : Antineoplastons
Diseases : Colon Cancer, Glioma, Glioma: Progressive Brainstem, Liver Cancer
Pharmacological Actions : 1-Glutamine Uptake Inhibitor, 1-Leucine Uptake Inhibitor, Histone deacetylase inhibitor, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Rosa rugosa extracts decreased androgen receptor-mediated transcription and reduced LNCaP cell growth.Aug 12, 2008

Pubmed Data : J Ethnopharmacol. 2008 Aug 13 ;118(3):412-7. Epub 2008 May 13. PMID: 18562138
Article Published Date : Aug 12, 2008
Study Type : In Vitro Study
Additional Links
Substances : Rose
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Enzyme Inhibitors, Histone deacetylase inhibitor
Additional Keywords : Plant Extracts
[+]

SAHA and parthenolide has a synergistic effect in MDA-MB231 breast cancer cells.May 31, 2015

Pubmed Data : J Cell Physiol. 2015 Jun ;230(6):1276-89. PMID: 25370819
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Histone deacetylase inhibitor, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Spermidine and resveratrol mediates pharmacological lifespan extension through the up-regulation of autophagy.Dec 01, 2009

Pubmed Data : Aging (Albany NY). 2009 Dec;1(12):961-70. Epub 2009 Dec 23. PMID: 20157579
Article Published Date : Dec 01, 2009
Study Type : Review
Additional Links
Substances : Resveratrol, Spermidine
Diseases : Aging
Pharmacological Actions : Autophagy Up-regulation, Histone deacetylase inhibitor
Additional Keywords : Stilbenes
[+]

Sulforaphane and epigallocatechin-3-gallate (EGCG) can positively modulate the epigenome and lead to many health benefits.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Biol. 2015 Jan 1 ;218(Pt 1):59-70. PMID: 25568452
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Polyphenols, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Modification, Histone Modifications
[+]

Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma.Mar 24, 2020

Pubmed Data : Eur J Nutr. 2020 Mar 25. Epub 2020 Mar 25. PMID: 32215717
Article Published Date : Mar 24, 2020
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Sulforaphane
Diseases : Malignant Melanoma
Pharmacological Actions : Chemotherapeutic, Histone deacetylase inhibitor
[+]

Sulforaphane can increase the antimicrobial peptide secretion of beta-defensin 2 in intestinal cells.Oct 01, 2008

Pubmed Data : Immunology. 2008 Oct;125(2):241-51. Epub 2008 Mar 27. PMID: 18373608
Article Published Date : Oct 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Gastrointestinal Diseases, Immune Disorders: Low Immune Function, Intestinal Diseases, Low Disorders: Low TH1
Pharmacological Actions : Beta-Defensin-2 Up-Regulation, Enzyme Inhibitors, Histone deacetylase inhibitor, NF-kappaB Inhibitor
[+]

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.Sep 29, 2009

Pubmed Data : Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16663-8. Epub 2009 Sep 15. PMID: 19805354
Article Published Date : Sep 29, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Androgen-Induced Diseases, Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Histone deacetylase inhibitor
[+]

Sulforaphane may be a therapeutic agent for lung cancer through the inhibition of HDAC.Feb 29, 2016

Pubmed Data : Biomed Pharmacother. 2016 Mar ;78:74-80. Epub 2016 Jan 14. PMID: 26898427
Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Histone deacetylase inhibitor
[+]

Sulforaphane's antioxidant, anti-inflammatory, and histone deacetylase inhibiting properties may improve schizophrenia symptoms.Jun 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019 Jun 28 ;44(6):701-705. PMID: 31304933
Article Published Date : Jun 28, 2019
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Schizophrenia, Schizophrenic Disorders
Pharmacological Actions : Anti Inflammatory, Antioxidant Effects, Histone deacetylase inhibitor
Additional Keywords : Isothiocyanates
[+]

Sulforaphane's multifaceted potential: from neuroprotection to anticancer action.Sep 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2023 Oct 1 ;28(19). Epub 2023 Oct 1. PMID: 37836745
Article Published Date : Sep 30, 2023
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Cerebral Ischemia
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Chemosensitizer, Histone deacetylase inhibitor, Neuroprotective Agents, Nrf2 activation
[+]

Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.Jan 10, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Science. 2013 Jan 11 ;339(6116):211-4. Epub 2012 Dec 6. PMID: 23223453
Article Published Date : Jan 10, 2013
Study Type : In Vitro Study
Additional Links
Substances : Ketone Bodies
Diseases : Lipid Peroxidation, Oxidative Stress
Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic
Pharmacological Actions : Antioxidants, Histone deacetylase inhibitor, Superoxide Dismutase Up-regulation
[+]

T. serpyllum extract induced significant cytotoxicity in breast cancer cells MCF-7 and MDA-MB-231 but not in normal cells.Dec 31, 2011

Pubmed Data : Nutr Cancer. 2012 ;64(8):1245-50. PMID: 23163852
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Thyme
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification, Plant Extracts, Selective Cytotoxicity
[+]

The anti-inflammatory effects of Spirulina platensis extracts act via the modulation of histone deacetylases.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 ;8(6). Epub 2016 Jun 21. PMID: 27338466
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Spirulina
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Histone deacetylase inhibitor
Additional Keywords : Dose Response, Epigenetic Modification
[+]

The intake of dietary compounds that regulate epigenetic modifications can provide significant health benefits preventing various processes in the development of cancer and other life-threatening diseases.May 09, 2015

Pubmed Data : Gene. 2015 May 10 ;562(1):8-15. Epub 2015 Feb 19. PMID: 25701602
Article Published Date : May 09, 2015
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Flavonoids, Genistein, Indole-3-Carbinol, Resveratrol, Stilbenes
Diseases : Cancers: All
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification
[+]

The ketone body metabolite β-hydroxybutyrate induces an antidepression-associated ramification of microglia.Jan 31, 2018

Pubmed Data : Glia. 2018 Feb ;66(2):256-278. Epub 2017 Oct 23. PMID: 29058362
Article Published Date : Jan 31, 2018
Study Type : Review
Additional Links
Substances : Ketone Bodies
Diseases : Brain: Microglial Activation, Depression
Pharmacological Actions : Antidepressive Agents, Histone deacetylase inhibitor
[+]

The ketone metabolite β-hydroxybutyrate attenuates oxidative stress in spinal cord injury.Sep 14, 2017

Pubmed Data : J Neurotrauma. 2017 Sep 15 ;34(18):2645-2655. Epub 2017 Aug 4. PMID: 28683591
Article Published Date : Sep 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ketone Bodies
Diseases : Oxidative Stress, Spinal Cord Injuries
Pharmacological Actions : Antioxidants, Histone deacetylase inhibitor
[+]

Theophylline and curcumin may restore corticosteroid insensitivity. Jun 01, 2007

Pubmed Data : Expert Opin Ther Targets. 2007 Jun;11(6):745-55. PMID: 17504013
Article Published Date : Jun 01, 2007
Study Type : Review
Additional Links
Substances : Curcumin, Theophylline
Diseases : Asthma, Corticosteroid-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : Corticosteroid Sparing
[+]

This review focuses on plant derived HDACi Sulforaphane as a promising molecule against pancreatic cancer therapy.Jun 05, 2016

Pubmed Data : Anticancer Agents Med Chem. 2016 Jun 6. Epub 2016 Jun 6. PMID: 27281367
Article Published Date : Jun 05, 2016
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor
[+]

This review summarizes the current knowledge on the effect of curcumin in the treatment and prevention of inflammation, neurodegenerative diseases and cancers.Mar 31, 2015

Pubmed Data : Curr Pharmacol Rep. 2015 Apr ;1(2):129-139. Epub 2015 Jan 30. PMID: 26457241
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Cancers: All, Inflammation, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Histone deacetylase inhibitor, Neuroprotective Agents
Additional Keywords : Epigenetic Modification
[+]

This review summarizes the epigenetic mechanisms by which active compounds from Chinese herbs exert their anti-cancer effect.Sep 29, 2016

Pubmed Data : Pharmacol Res. 2016 Sep 30. Epub 2016 Aug 30. PMID: 27697644
Article Published Date : Sep 29, 2016
Study Type : Review
Additional Links
Substances : Curcumin, Resveratrol
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer
[+]

This review summarizes the mechanisms, namely through targeting DNA methyltransferases, inhibiting histone deactylases, and activating Nrf2.Jan 01, 2018

Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5438179. Epub 2018 Jun 6. PMID: 29977456
Article Published Date : Jan 01, 2018
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antioxidant Effects, Histone deacetylase inhibitor, Nrf2 activation
Additional Keywords : DNA Methylation, DNA Methyltransferase, Epigenetic Modification, Isothiocyanates
[+]

This shows that genistein could be an important arsenal in the development of epigenetic based cancer therapy.Sep 17, 2017

Pubmed Data : Anticancer Agents Med Chem. 2017 Sep 18. Epub 2017 Sep 18. PMID: 28925878
Article Published Date : Sep 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification
[+]

Treatment of HT29 human colorectal cancer cell line with nanocarrier-encapsulated camptothecin.Nov 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Nov 13 ;22(22). Epub 2021 Nov 13. PMID: 34830168
Article Published Date : Nov 12, 2021
Study Type : In Vitro Study
Additional Links
Substances : Camptothecin
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Histone deacetylase inhibitor, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Epigenetic Modification In Cancer
[+]

Vitamin C supplied protection against the cell cycle arrest induced by aromatic alkylanilines.Apr 30, 2015

Pubmed Data : J Appl Toxicol. 2015 May ;35(5):466-77. Epub 2014 Sep 1. PMID: 25178734
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Bladder Cancer, DNA damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification
[+]

Zingiber zerumbet (a member of the ginger family) contains compounds that inhibit histone deacetylase and exhibited growth inhibitory activity on various human tumor cell lines.Oct 01, 2008

Pubmed Data : Pharmazie. 2008 Oct;63(10):774-6. PMID: 18972844
Article Published Date : Oct 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Ginger
Diseases : Tumors
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor

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