Histone deacetylase inhibitor

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45 Substances Researched for Histone deacetylase inhibitor
NameACCKFocus
Sulforaphane1424Locked
Curcumin1313Locked
Ginsenosides46Locked
Thymoquinone15Locked
Butyrate34Locked
Genistein34Locked
Resveratrol33Locked
Astragaloside12Locked
Cucurbitacin B 12Locked
Curcumol12Locked
EGCG (Epigallocatechin gallate)22Locked
Polyphenols22Locked
Probiotics22Locked
Antineoplastons11Locked
Apples11Locked
Astaxanthin11Locked
Belamcanda chinensis 11Locked
Catechin 11Locked
Charcone11Locked
Chrysin11Locked
Cruciferous Vegetables11Locked
Feijoa11Locked
Flavonoids11Locked
Formononetin11Locked
Ginger11Locked
Ginseng (Siberian)11Locked
Green Tea11Locked
Homeopathic Medicine: All11Locked
Indole-3-Carbinol11Locked
Isothiocyanates11Locked
Magnolia11Locked
Magnolol11Locked
Oleuropein11Locked
Parthenolide11Locked
Patchouli11Locked
Phenethyl isothiocyanate11Locked
Quercetin11Locked
Rose 11Locked
Spermidine 11Locked
Spirulina11Locked
Stilbenes11Locked
Theophylline11Locked
Thyme11Locked
Vitamin C11Locked
phytoestrogens11Locked

View the Evidence:
74 Abstracts with Histone deacetylase inhibitor Research

[+]

Rapid changes in histone deacetylases and inflammatory gene expression in expert meditatorsJan 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Psychoneuroendocrinology. 2014 Feb ;40:96-107. Epub 2013 Nov 15. PMID: 24485481
Article Published Date : Jan 31, 2014
Study Type : Human Study
Additional Links
Diseases : Inflammation
Therapeutic Actions : Meditation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Histone deacetylase inhibitor
Additional Keywords : Gene Expression Regulation
[+]

Sulforaphane has a novel chemopreventive mechanism in human colon cancer cells and prostate epithelial cells, namely the inhibition of histone deacetylase (HDAC). IFeb 01, 2007

Pubmed Data : Exp Biol Med (Maywood). 2007 Feb;232(2):227-34. PMID: 17259330
Article Published Date : Feb 01, 2007
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer, Prostate Cancer, Prostate Cancer: Prevention
Pharmacological Actions : Chemopreventive, Enzyme Inhibitors, Histone deacetylase inhibitor
[+]

Thymoquinone promotes pancreatic cancer cell death and reduction of tumor size.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Prev Med. 2016 ;2016:1407840. Epub 2016 Dec 26. PMID: 28105374
Article Published Date : Dec 31, 2015
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Thymoquinone
Diseases : Pancreatic Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Histone deacetylase inhibitor, P21 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Dose Response
[+]

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain.Dec 27, 2020

Pubmed Data : Front Med. 2020 Dec 28. Epub 2020 Dec 28. PMID: 33369712
Article Published Date : Dec 27, 2020
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Brain Ischemia
Pharmacological Actions : Histone deacetylase inhibitor, Immunomodulatory
[+]

Curcumol controls choriocarcinoma stem-like cells self-renewal.Jan 23, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Jan 24 ;24:461-472. Epub 2018 Jan 24. PMID: 29363667
Article Published Date : Jan 23, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Choriocarcinoma
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : Cancer Stem Cells, Epigenetic Modification In Cancer
[+]

Ginsenoside 20(s)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells.Dec 04, 2015

Pubmed Data : Chem Biol Interact. 2015 Dec 5 ;242:227-34. Epub 2015 Oct 19. PMID: 26482938
Article Published Date : Dec 04, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Leukemia
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor
[+]

Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(12):e115401. Epub 2014 Dec 18. PMID: 25521755
Article Published Date : Dec 31, 2013
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Melanoma
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Histone deacetylase inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Sulforaphane attenuates cisplatin-induced hearing loss.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2021 ;35:20587384211034086. PMID: 34344210
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemotherapy-Induced Toxicity: Cisplatin
Pharmacological Actions : Chemoprotective Agents, Histone deacetylase inhibitor
[+]

The effects of combinatorial genistein and sulforaphane in breast tumor inhibition: role in epigenetic regulation.Jun 12, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2018 Jun 13 ;19(6). Epub 2018 Jun 13. PMID: 29899271
Article Published Date : Jun 12, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genistein, Sulforaphane
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antineoplastic Agents, Chemotherapeutic, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer, Natural Substance Synergy
[+]

This study is the first to show a beneficial effect of butyrate on muscle mass during aging.Nov 30, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Cell. 2015 Dec ;14(6):957-70. Epub 2015 Aug 20. PMID: 26290460
Article Published Date : Nov 30, 2015
Study Type : Animal Study
Additional Links
Substances : Butyrate
Diseases : Sarcopenia
Pharmacological Actions : Antioxidants, Histone deacetylase inhibitor
[+]

This study provides new insights into cucurbitacin B mediated epigenetic alterations and its chemotherapeutic effects on lung cancer.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Prev Res (Phila). 2015 Jun ;8(6):552-62. Epub 2015 Mar 26. PMID: 25813524
Article Published Date : May 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Cucurbitacin B
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer, Gene Expression Regulation, Reactivation Of Tumor Suppressor Gene
[+]

"EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity."Jun 30, 2012

Pubmed Data : Int J Mol Med. 2012 Jul ;30(1):69-74. Epub 2012 Apr 10. PMID: 22505206
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Histone deacetylase inhibitor
[+]

"Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class I histone deacetylases."Jun 30, 2012

Pubmed Data : Int J Oncol. 2012 Jul ;41(1):353-61. Epub 2012 Apr 26. PMID: 22552582
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Catechin , Polyphenols
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Histone deacetylase inhibitor, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Epigenetic Modification, Plant Extracts
[+]

21 hTERT down-regulation by HDAC1 inhibition is a promising approach for delaying or preventing colorectal cancer.Feb 04, 2017

Pubmed Data : Curr Cancer Drug Targets. 2017 Feb 5. Epub 2017 Feb 5. PMID: 28176652
Article Published Date : Feb 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Modification In Cancer
[+]

3,3'-Diindolylmethane inhibits histone deacetylase activity in prostate cancer cells.Sep 14, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Appl Pharmacol. 2012 Sep 15 ;263(3):345-51. Epub 2012 Jul 16. PMID: 22800507
Article Published Date : Sep 14, 2012
Study Type : In Vitro Study
Additional Links
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Histone deacetylase inhibitor, P21 Activation
[+]

A. senticosus exhibited a potential for inhibition of histone deacetylase.May 31, 2016

Pubmed Data : Exp Hematol. 2016 Jun ;44(6):466-73. Epub 2016 Mar 15. PMID: 26992299
Article Published Date : May 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Ginseng (Siberian)
Diseases : Cancers: Drug Resistant, Leukemia, Promyelocytic leukemia
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer, Plant Extracts
[+]

Anti-rheumatic activity of phenethyl isothiocyanate via inhibition of histone deacetylase-1.May 31, 2020

Pubmed Data : Chem Biol Interact. 2020 Jun 1 ;324:109095. Epub 2020 Apr 11. PMID: 32289289
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Phenethyl isothiocyanate
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Apple may exert its protective effect against colorectal cancer through acting as a histone-deacetylase inhibitor. Apr 01, 2008

Pubmed Data : Nutrition. 2008 Apr;24(4):366-74. Epub 2008 Feb 11. PMID: 18262392
Article Published Date : Apr 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Apples
Diseases : Colorectal Cancer
Pharmacological Actions : Enzyme Inhibitors, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification, Plant Extracts
[+]

Astaxanthin reduced the protein expression of DNMT3b and significantly inhibited DNMT and HDAC activities in vitro.Dec 01, 2016

Pubmed Data : AAPS J. 2016 Dec 2. Epub 2016 Dec 2. PMID: 27913949
Article Published Date : Dec 01, 2016
Study Type : In Vitro Study
Additional Links
Substances : Astaxanthin
Diseases : Prostate Cancer
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : DNA Methyltransferase, Epigenetic Modification In Cancer
[+]

Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases.Jun 04, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2018 Jun 5 ;9(43):27280-27292. Epub 2018 Jun 5. PMID: 29930765
Article Published Date : Jun 04, 2018
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Colorectal Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor
[+]

Butyrate induced apoptosis and inhibited cell proliferation via enhancing the intracellular expression of miR-22.Mar 06, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2017 Mar 7 ;12:340-349. Epub 2017 Mar 7. PMID: 28288414
Article Published Date : Mar 06, 2017
Study Type : In Vitro Study
Additional Links
Substances : Butyrate
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Antiproliferative, Apoptotic, Butyrate, Histone deacetylase inhibitor, liver cancer, MicroRNA modulator
[+]

Chalcone and curcumin derivatives: a way ahead for malarial treatment.Nov 30, 2013

Pubmed Data : Mini Rev Med Chem. 2013 Dec ;13(14):2116-33. PMID: 24160709
Article Published Date : Nov 30, 2013
Study Type : Review
Additional Links
Substances : Charcone, Curcumin
Diseases : Malaria
Pharmacological Actions : Antimalarials, Histone deacetylase inhibitor
[+]

Chrysin as an emerging histone deacetylase inhibitor for prosperous epigenetic-based anticancer therapy.Sep 14, 2020

Pubmed Data : Phytother Res. 2020 Sep 15. Epub 2020 Sep 15. PMID: 32930436
Article Published Date : Sep 14, 2020
Study Type : In Vitro Study
Additional Links
Substances : Chrysin
Diseases : Cancers: All
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Condurango 30C appeared to trigger key epigenetic events of gene modulation in effectively combating cancer cells, which the placebo was unable to do.Nov 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacopuncture. 2013 Dec ;16(4):7-13. PMID: 25780677
Article Published Date : Nov 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Homeopathic Medicine: All
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Histone deacetylase inhibitor, P21 Activation, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Epigenetic Modification In Cancer, Homeopathic Vs. Conventional Treatment, Low-Dose Pharmacology
[+]

Curcumin exhibits B-cell lymphoma cell proliferation.May 01, 2006

Pubmed Data : Ai Zheng. 2006 May;25(5):582-6. PMID: 16687078
Article Published Date : May 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Lymphoma: B-Cell
Pharmacological Actions : Anti-Proliferative, Antineoplastic Agents, Cell cycle arrest, Histone deacetylase inhibitor
[+]

Curcumin exhibits histone deacetylase inhibitor activity in malignant hematologic cells.Feb 01, 2009

Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2009 Feb;29(1):25-8. Epub 2009 Feb 18. PMID: 19224157
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Hematologic Diseases
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Histone deacetylase inhibitor
[+]

Curcumin had an inhibitory effect on anchorage independent growth of HT29 cells at least in part by the epigenetic demethylation and up-regulation of DLEC1.Mar 14, 2015

Pubmed Data : Biochem Pharmacol. 2015 Mar 15 ;94(2):69-78. Epub 2015 Jan 29. PMID: 25640947
Article Published Date : Mar 14, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer, Colon Cancer: Prevention
Pharmacological Actions : Chemotherapeutic, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification, Reactivation Of Tumor Suppressor Gene
[+]

Curcumin is a histone deacetylase inhibitor.Apr 15, 2005

Pubmed Data : Biochem Pharmacol. 2005 Apr 15;69(8):1205-13. PMID: 15794941
Article Published Date : Apr 15, 2005
Study Type : Review
Additional Links
Substances : Curcumin
Pharmacological Actions : Antineoplastic Agents, Histone deacetylase inhibitor
[+]

Curcumin is a natural pan-histone deacetylase inhibitor in cancer.Nov 13, 2017

Pubmed Data : Curr Pharm Des. 2017 Nov 14. Epub 2017 Nov 14. PMID: 29141538
Article Published Date : Nov 13, 2017
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Cancers: All
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Curcumin is an inhibitor of p300 histone acetylatransferase capable of blocking prostate cancer cells.Mar 01, 2006

Pubmed Data : Med Chem. 2006 Mar;2(2):169-74. PMID: 16787365
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Enzyme Inhibitors, Histone deacetylase inhibitor, Proteasome Inhibitors
[+]

Curcumin may have therapeutic value in HIV infection.Feb 19, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Feb 19. Epub 2010 Feb 19. PMID: 15383533
Article Published Date : Feb 19, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : HIV Infections
Pharmacological Actions : Antiproliferative , Apoptotic, Enzyme Inhibitors, Histone deacetylase inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-Cell lymphoma cell line proliferation.May 01, 2005

Pubmed Data : Acta Pharmacol Sin. 2005 May;26(5):603-9. PMID: 15842781
Article Published Date : May 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Lymphoma: B-Cell
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Histone deacetylase inhibitor
[+]

Diallyl trisulfides, a natural histone deacetylase inhibitor, attenuate HIF-1α synthesis, and decreases breast cancer metastasis.Jan 09, 2017

Pubmed Data : Mol Carcinog. 2017 10 ;56(10):2317-2331. Epub 2017 Jul 6. PMID: 28574600
Article Published Date : Jan 09, 2017
Study Type : In Vitro Study
Additional Links
Substances : Organosulfur Compounds
Diseases : Breast Cancer
Pharmacological Actions : Anti-metastatic, Histone deacetylase inhibitor, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
[+]

Diet, microbiota and gut microbial metabolites can modulate the progression of inflammatory diseases and autoimmunity.Apr 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Transl Immunology. 2016 May ;5(5):e82. Epub 2016 May 13. PMID: 27350881
Article Published Date : Apr 30, 2016
Study Type : Review
Additional Links
Substances : Probiotics
Diseases : Arthritis, Asthma, Autoimmune Diseases, Inflammation, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Histone deacetylase inhibitor
Additional Keywords : Dietary Modification, Microbiota
[+]

Dietary sulforaphane is a histone deacetylase inhibitor for cancer prevention.Dec 01, 2009

Pubmed Data : J Nutr. 2009 Dec;139(12):2393-6. Epub 2009 Oct 7. PMID: 19812222
Article Published Date : Dec 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Enzyme Inhibitors, Histone deacetylase inhibitor
[+]

Downregulation of HDAC3 by ginsenoside Rg3 inhibits epithelial-mesenchymal transition of cutaneous squamous cell carcinoma.Jun 12, 2019

Pubmed Data : J Cell Physiol. 2019 Jun 13. Epub 2019 Jun 13. PMID: 31192452
Article Published Date : Jun 12, 2019
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Squamous cell carcinoma
Pharmacological Actions : Anti-metastatic, Chemotherapeutic, Histone deacetylase inhibitor
[+]

Farnesiferol C induces apoptosis in chronic myelogenous leukemia cells as an imatinib sensitizer.Nov 05, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Nov 6 ;20(22). Epub 2019 Nov 6. PMID: 31698777
Article Published Date : Nov 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Asafoetida
Diseases : Leukemia: Chronic myelogenous leukemia (CML)
Pharmacological Actions : Apoptotic, Chemosensitizer, Histone deacetylase inhibitor
Additional Keywords : Chemothapeutic Synergy: Imatinib
[+]

Feijoa apoptotic active principle is the Flavone and that this activity correlates with the induction of HDAC inhibitionDec 31, 2006

Pubmed Data : Int J Biochem Cell Biol. 2007 ;39(10):1902-14. Epub 2007 May 25. PMID: 17604209
Article Published Date : Dec 31, 2006
Study Type : In Vitro Study
Additional Links
Substances : Feijoa
Diseases : Acute Myeloid Leukemia, Cancers: All
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Histone deacetylase inhibitor
Additional Keywords : Plant Extracts, Selective Cytotoxicity
[+]

Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(6):6434-41. Epub 2015 Jun 1. PMID: 26261519
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Glioma
Pharmacological Actions : Antiproliferative , Chemosensitizer, Histone deacetylase inhibitor
Additional Keywords : Chemotherapeutic Synergy: Doxorubicin
[+]

Ginsenoside Rh2 markedly inhibited the migration ability of HepG2 cells.Sep 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2014 Oct ;10(4):1779-85. Epub 2014 Jul 18. PMID: 25051397
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Liver Cancer
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor
[+]

HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.Apr 05, 2018

Pubmed Data : Int J Cancer. 2018 Apr 6. Epub 2018 Apr 6. PMID: 29633255
Article Published Date : Apr 05, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Histone deacetylase modifications by probiotics in colorectal cancer.Dec 05, 2019

Pubmed Data : J Gastrointest Cancer. 2019 Dec 6. Epub 2019 Dec 6. PMID: 31808058
Article Published Date : Dec 05, 2019
Study Type : Review
Additional Links
Substances : Probiotics
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Histone deacetylase inhibitor
[+]

In this review, they discuss the biochemical and biological properties of sulforaphane with a particular emphasis on the anticancer properties of the dietary compound.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxid Redox Signal. 2015 Jun 1 ;22(16):1382-424. Epub 2014 Dec 19. PMID: 25364882
Article Published Date : May 31, 2015
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive, Histone deacetylase inhibitor, NF-kappaB Inhibitor, Phase II Detoxification Enzyme Inducer
Additional Keywords : Dietary Concentrations, Selective Cytotoxicity
[+]

Incorporation of an epigenetic diet may in fact be the key to chemoprevention.Jan 31, 2015

Pubmed Data : Curr Pharmacol Rep. 2015 Feb 1 ;1(1):46-51. PMID: 25774338
Article Published Date : Jan 31, 2015
Study Type : Review
Additional Links
Substances : Cruciferous Vegetables
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Diet, Epigenetic Modification
[+]

Magnolol and polyphenol mixture remarkably induced cell apoptosis by arresting the cell cycle in the G0/G1 phase.Jun 02, 2016

Pubmed Data : Pharmacol Res. 2016 Jun 3 ;111:113-125. Epub 2016 Jun 3. PMID: 27268146
Article Published Date : Jun 02, 2016
Study Type : In Vitro Study
Additional Links
Substances : Magnolia, Magnolol
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor
[+]

Oleuropein has the potential to be a therapeutic drug for breast cancer prevention and treatment.May 21, 2019

Pubmed Data : J Cell Biochem. 2019 May 22. Epub 2019 May 22. PMID: 31119806
Article Published Date : May 21, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oleuropein
Diseases : Breast Cancer
Pharmacological Actions : Chemopreventive, Histone deacetylase inhibitor
[+]

PaDef a plant peptide triggers apoptosis, and induces global epigenetic modifications on histone 3 in an acute lymphoid leukemia cell line.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Mol Biosci. 2022 ;9:801816. Epub 2022 Jan 24. PMID: 35141282
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Avocado
Diseases : Acute lymphoblastic leukemia (ALL)
Pharmacological Actions : Apoptotic, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer
[+]

Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells.May 31, 2013

Pubmed Data : Int Immunopharmacol. 2013 Jun ;16(2):184-90. Epub 2013 Apr 17. PMID: 23602914
Article Published Date : May 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Patchouli
Diseases : Colorectal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Histone deacetylase inhibitor, NF-kappaB Inhibitor
[+]

Phytoestrogens regulate the proliferation and expression of stem cell factors in cell lines of malignant testicular germ cell tumors.Aug 19, 2013

Pubmed Data : Int J Oncol. 2013 Aug 20. Epub 2013 Aug 20. PMID: 23969837
Article Published Date : Aug 19, 2013
Study Type : In Vitro Study
Additional Links
Substances : Belamcanda chinensis , phytoestrogens
Diseases : Testicular Cancer Stem Cells
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor
[+]

Polyphenols from green tea inhibit the growth of melanoma cells.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Genes Cancer. 2015 Jan ;6(1-2):49-61. PMID: 25821561
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Green Tea
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor
[+]

Quercetin induces human leukemia cell death via histone hyperacetylation.May 01, 2008

Pubmed Data : Pharmazie. 2008 May;63(5):379-83. PMID: 18557424
Article Published Date : May 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Leukemia
Pharmacological Actions : Histone deacetylase inhibitor
[+]

Review: curcumin may be an ideal epigenetic agent.Oct 15, 2010

Pubmed Data : Cancer. 2010 Oct 15;116(20):4670-6. PMID: 20597137
Article Published Date : Oct 15, 2010
Study Type : Review
Additional Links
Substances : Curcumin
Pharmacological Actions : Antineoplastic Agents, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification
[+]

Review: The present state of antineoplaston research (1)Mar 01, 2004

Pubmed Data : Integr Cancer Ther. 2004 Mar ;3(1):47-58. PMID: 15035876
Article Published Date : Mar 01, 2004
Study Type : Review
Additional Links
Substances : Antineoplastons
Diseases : Colon Cancer, Glioma, Glioma: Progressive Brainstem, Liver Cancer
Pharmacological Actions : 1-Glutamine Uptake Inhibitor, 1-Leucine Uptake Inhibitor, Histone deacetylase inhibitor, P21 Activation, Tumor Suppressor Protein p53 Upregulation
[+]

Rosa rugosa extracts decreased androgen receptor-mediated transcription and reduced LNCaP cell growth.Aug 12, 2008

Pubmed Data : J Ethnopharmacol. 2008 Aug 13 ;118(3):412-7. Epub 2008 May 13. PMID: 18562138
Article Published Date : Aug 12, 2008
Study Type : In Vitro Study
Additional Links
Substances : Rose
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Enzyme Inhibitors, Histone deacetylase inhibitor
Additional Keywords : Plant Extracts
[+]

SAHA and parthenolide has a synergistic effect in MDA-MB231 breast cancer cells.May 31, 2015

Pubmed Data : J Cell Physiol. 2015 Jun ;230(6):1276-89. PMID: 25370819
Article Published Date : May 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Breast Cancer
Pharmacological Actions : Apoptotic, Histone deacetylase inhibitor, NF-kappaB Inhibitor
Additional Keywords : Natural Substance/Drug Synergy
[+]

Spermidine and resveratrol mediates pharmacological lifespan extension through the up-regulation of autophagy.Dec 01, 2009

Pubmed Data : Aging (Albany NY). 2009 Dec;1(12):961-70. Epub 2009 Dec 23. PMID: 20157579
Article Published Date : Dec 01, 2009
Study Type : Review
Additional Links
Substances : Resveratrol, Spermidine
Diseases : Aging
Pharmacological Actions : Autophagy Up-regulation, Histone deacetylase inhibitor
Additional Keywords : Stilbenes
[+]

Sulforaphane and epigallocatechin-3-gallate (EGCG) can positively modulate the epigenome and lead to many health benefits.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Exp Biol. 2015 Jan 1 ;218(Pt 1):59-70. PMID: 25568452
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Polyphenols, Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Histone deacetylase inhibitor, MicroRNA modulator
Additional Keywords : Epigenetic Modification, Histone Modifications
[+]

Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma.Mar 24, 2020

Pubmed Data : Eur J Nutr. 2020 Mar 25. Epub 2020 Mar 25. PMID: 32215717
Article Published Date : Mar 24, 2020
Study Type : In Vitro Study
Additional Links
Substances : Isothiocyanates, Sulforaphane
Diseases : Malignant Melanoma
Pharmacological Actions : Chemotherapeutic, Histone deacetylase inhibitor
[+]

Sulforaphane can increase the antimicrobial peptide secretion of beta-defensin 2 in intestinal cells.Oct 01, 2008

Pubmed Data : Immunology. 2008 Oct;125(2):241-51. Epub 2008 Mar 27. PMID: 18373608
Article Published Date : Oct 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Gastrointestinal Diseases, Immune Disorders: Low Immune Function, Intestinal Diseases, Low Disorders: Low TH1
Pharmacological Actions : Beta-Defensin-2 Up-Regulation, Enzyme Inhibitors, Histone deacetylase inhibitor, NF-kappaB Inhibitor
[+]

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.Sep 29, 2009

Pubmed Data : Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16663-8. Epub 2009 Sep 15. PMID: 19805354
Article Published Date : Sep 29, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Androgen-Induced Diseases, Prostate Cancer
Pharmacological Actions : Anticarcinogenic Agents, Histone deacetylase inhibitor
[+]

Sulforaphane may be a therapeutic agent for lung cancer through the inhibition of HDAC.Feb 29, 2016

Pubmed Data : Biomed Pharmacother. 2016 Mar ;78:74-80. Epub 2016 Jan 14. PMID: 26898427
Article Published Date : Feb 29, 2016
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Lung Cancer, Lung Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Histone deacetylase inhibitor
[+]

Sulforaphane's antioxidant, anti-inflammatory, and histone deacetylase inhibiting properties may improve schizophrenia symptoms.Jun 28, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019 Jun 28 ;44(6):701-705. PMID: 31304933
Article Published Date : Jun 28, 2019
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Schizophrenia, Schizophrenic Disorders
Pharmacological Actions : Anti Inflammatory, Antioxidant Effects, Histone deacetylase inhibitor
Additional Keywords : Isothiocyanates
[+]

T. serpyllum extract induced significant cytotoxicity in breast cancer cells MCF-7 and MDA-MB-231 but not in normal cells.Dec 31, 2011

Pubmed Data : Nutr Cancer. 2012 ;64(8):1245-50. PMID: 23163852
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Thyme
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification, Plant Extracts, Selective Cytotoxicity
[+]

The anti-inflammatory effects of Spirulina platensis extracts act via the modulation of histone deacetylases.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 ;8(6). Epub 2016 Jun 21. PMID: 27338466
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Spirulina
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Histone deacetylase inhibitor
Additional Keywords : Dose Response, Epigenetic Modification
[+]

The intake of dietary compounds that regulate epigenetic modifications can provide significant health benefits preventing various processes in the development of cancer and other life-threatening diseases.May 09, 2015

Pubmed Data : Gene. 2015 May 10 ;562(1):8-15. Epub 2015 Feb 19. PMID: 25701602
Article Published Date : May 09, 2015
Study Type : Review
Additional Links
Substances : EGCG (Epigallocatechin gallate), Flavonoids, Genistein, Indole-3-Carbinol, Resveratrol, Stilbenes
Diseases : Cancers: All
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification
[+]

Theophylline and curcumin may restore corticosteroid insensitivity. Jun 01, 2007

Pubmed Data : Expert Opin Ther Targets. 2007 Jun;11(6):745-55. PMID: 17504013
Article Published Date : Jun 01, 2007
Study Type : Review
Additional Links
Substances : Curcumin, Theophylline
Diseases : Asthma, Corticosteroid-Induced Toxicity, Oxidative Stress
Pharmacological Actions : Histone deacetylase inhibitor
Additional Keywords : Corticosteroid Sparing
[+]

This review focuses on plant derived HDACi Sulforaphane as a promising molecule against pancreatic cancer therapy.Jun 05, 2016

Pubmed Data : Anticancer Agents Med Chem. 2016 Jun 6. Epub 2016 Jun 6. PMID: 27281367
Article Published Date : Jun 05, 2016
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Pancreatic Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Histone deacetylase inhibitor
[+]

This review summarizes the current knowledge on the effect of curcumin in the treatment and prevention of inflammation, neurodegenerative diseases and cancers.Mar 31, 2015

Pubmed Data : Curr Pharmacol Rep. 2015 Apr ;1(2):129-139. Epub 2015 Jan 30. PMID: 26457241
Article Published Date : Mar 31, 2015
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Cancers: All, Inflammation, Neurodegenerative Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Histone deacetylase inhibitor, Neuroprotective Agents
Additional Keywords : Epigenetic Modification
[+]

This review summarizes the epigenetic mechanisms by which active compounds from Chinese herbs exert their anti-cancer effect.Sep 29, 2016

Pubmed Data : Pharmacol Res. 2016 Sep 30. Epub 2016 Aug 30. PMID: 27697644
Article Published Date : Sep 29, 2016
Study Type : Review
Additional Links
Substances : Curcumin, Resveratrol
Diseases : Cancers: All
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification In Cancer
[+]

This review summarizes the mechanisms, namely through targeting DNA methyltransferases, inhibiting histone deactylases, and activating Nrf2.Jan 01, 2018

Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5438179. Epub 2018 Jun 6. PMID: 29977456
Article Published Date : Jan 01, 2018
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress
Pharmacological Actions : Anticarcinogenic Agents, Antioxidant Effects, Histone deacetylase inhibitor, Nrf2 activation
Additional Keywords : DNA Methylation, DNA Methyltransferase, Epigenetic Modification, Isothiocyanates
[+]

This shows that genistein could be an important arsenal in the development of epigenetic based cancer therapy.Sep 17, 2017

Pubmed Data : Anticancer Agents Med Chem. 2017 Sep 18. Epub 2017 Sep 18. PMID: 28925878
Article Published Date : Sep 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification
[+]

Treatment of HT29 human colorectal cancer cell line with nanocarrier-encapsulated camptothecin.Nov 12, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Nov 13 ;22(22). Epub 2021 Nov 13. PMID: 34830168
Article Published Date : Nov 12, 2021
Study Type : In Vitro Study
Additional Links
Substances : Camptothecin
Diseases : Colorectal Cancer
Pharmacological Actions : Chemopreventive, Histone deacetylase inhibitor, Wnt/β-catenin signaling pathway modulation
Additional Keywords : Epigenetic Modification In Cancer
[+]

Vitamin C supplied protection against the cell cycle arrest induced by aromatic alkylanilines.Apr 30, 2015

Pubmed Data : J Appl Toxicol. 2015 May ;35(5):466-77. Epub 2014 Sep 1. PMID: 25178734
Article Published Date : Apr 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Vitamin C
Diseases : Bladder Cancer, DNA damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Histone deacetylase inhibitor
Additional Keywords : Epigenetic Modification
[+]

Zingiber zerumbet (a member of the ginger family) contains compounds that inhibit histone deacetylase and exhibited growth inhibitory activity on various human tumor cell lines.Oct 01, 2008

Pubmed Data : Pharmazie. 2008 Oct;63(10):774-6. PMID: 18972844
Article Published Date : Oct 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Ginger
Diseases : Tumors
Pharmacological Actions : Antiproliferative , Histone deacetylase inhibitor

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