Immunomodulatory

Name	AC	CK
Probiotics	20	107
Vitamin D	23	106
Echinacea	19	71
Curcumin	28	60
Fermented Foods and Beverages	8	55
Vitamin C	11	45
Lactobacillus plantarum	11	43
Garlic	9	42
Yoghurt	5	42
Gc protein-derived macrophage activating factor (GcMAF)	6	39
Selenium	6	38
Ginsenosides	20	30
Whey	2	30
Zinc	2	30
Ginseng (Korean)	7	28
Maitake Mushroom	13	28
Beta-glucan	6	27
Nigella sativa (aka Black Seed)	7	27
Polyphenols	10	25
Spirulina	6	25
Arginine	4	24
Bifidobacterium Infantis	4	24
Lactobacillus paracasei	4	24
Lactobacillus rhamnosus	4	24
Cannabidiol	12	22
Cannabis	8	22
Reishi Mushroom	9	21
Shiitake Mushroom	8	21
Bifidobacterium Longum	7	20
EGCG (Epigallocatechin gallate)	11	20
Evening Primrose Oil	2	20
Fruit: All	2	20
Homeopathic Medicine: All	6	20
Lactobacillus casei	6	20
Moringa oleifera	7	19
Turmeric	6	19
Bee Venom	6	18
Lactobacillus probiotics	6	18
Lactobacillus rhamnosus GG	5	17
Astragalus	5	15
Shikonin	4	15
Thymoquinone	11	15
Cannabinoids	5	14
Ginger	4	14
Rice Bran	4	14
Royal Jelly	4	14
Bee Propolis	4	13
Blueberry	3	13
Delta-tetrahydrocannabinol (THC)	8	13
Lactobacillus fermentum	3	13
Omega-3 Fatty Acids	3	13
Bacillus Clausii	3	12
Bromelain	3	12
Chlorella (Algae)	2	12
Guduchi	3	12
Modified Arabinoxylan Rice Bran (MGN-3)	2	12
Papaya: Fermented	2	12
White Button Mushroom	2	12
Broccoli Sprouts	2	11
Cucurbitacin B	2	11
Genistein	7	11
Green Tea	6	11
Lactobacillus salivarius	2	11
Resveratrol	7	11
Sea buckthorn	2	11
Alternanthera pungens	1	10
Bifidobacterium Lactis	1	10
Bloodroot	1	10
Camel Milk	1	10
Chaga Mushroom (Inonotus obliquus)	5	10
Garlic: Aged	1	10
Glutathione	1	10
Glycyrrhiza uralensis	1	10
Goji	1	10
Hemp Seed	1	10
Homeopathic Arsenicum album	1	10
Lactobacilius bulgaricus	1	10
Lactobacillus Brevis	1	10
Lactobacillus casei: Shirota	1	10
Lactobacillus helveticus	1	10
Lithospermum erythrorhizon	1	10
Oleic acid	1	10
Olive Oil	1	10
Pantethine	1	10
Pantothenic Acid (Vitamin B-5)	1	10
Ribonucleic acid (RNA)	1	10
Theanine	1	10
Tongkat Ali	1	10
Vegetables: All	1	10
Flavonoids	5	9
Melatonin	6	9
Aloe Vera	6	8
Apigenin	6	8
Ashwagandha	3	8
Mistletoe	4	8
Noni	4	8
Quercetin	6	8
Lion's Mane (Hericium Erinaceus)	5	7
Naringenin	5	7
Oligosaccharides	2	7
Prebiotics	5	7
Tanshinone IIA	4	7
Adlay	4	6
Andrographis	4	6
Astaxanthin	3	6
Berberine	4	6
Fucoidan	4	6
Mangiferin	4	6
Olive leaf extract	2	6
Sulforaphane	4	6
Anthocyanins	3	5
Bitter Melon	3	5
Fiber	3	5
Ginseng (Siberian)	3	5
Honey	4	5
Licorice	3	5
Lotus	3	5
Phloretin	3	5
Plantago	3	5
Purslane	3	5
Astragaloside	3	4
Black Pepper	2	4
Black Raspberry	2	4
Dandelion	2	4
Fig	2	4
Glutamine	2	4
Hesperidin	2	4
Milk: Fermented	2	4
NAC (N-acetyl-L-cysteine)	2	4
Onion	2	4
Papaya	3	4
Parthenolide	2	4
Peony	2	4
Raspberry	2	4
St. Johns Wort	2	4
Sweet Potato: Purple	2	4
Vitamin E	3	4
Vitamin E: alpha tocopherol	2	4
Arctigenin	2	3
Bael	2	3
Baicalein	2	3
Banana	2	3
Bisdemethoxycurcumin	2	3
Black Currant	2	3
Blue Honeysuckle	2	3
Chokeberry	2	3
Cinnamon	2	3
Cocoa	2	3
D-Mannose	3	3
Gallic Acid	2	3
Gingerol	2	3
Grape	2	3
Gynostemma	2	3
Kanuka Honey	1	3
Kefir	2	3
Medicinal Mushrooms	2	3
Pomegranate	2	3
Prickly Pear Cactus	2	3
Saccharomyces Boulardii	1	3
Saffron	2	3
Thyme	2	3
Verbascoside	2	3
White Mulberry	2	3
Zataria multiflora	2	3
Zerumbone	2	3
Acetic Acid	1	2
Agaricus Blazei	1	2
Amla Fruit	1	2
Amygdalin (laetrile)	1	2
Anandamide	1	2
Apples	1	2
Artichoke	1	2
Bamboo	1	2
Barberry	1	2
Beta-Caryophyllene	1	2
Beta-Elemene	1	2
Bifidobacterium Breve	1	2
Burdock	1	2
Butyrate	1	2
Cardamom	1	2
Carnosol	1	2
Cat's Claw	2	2
Catechin	1	2
Chinese Skullcap	1	2
Chrysin	2	2
Cinnamaldehyde	1	2
Coconut	1	2
Common bean	1	2
Cordyceps Militaris	1	2
Coumestrol	1	2
Cucurbitacin E	1	2
Cumin	1	2
DHA (Docosahexaenoic Acid)	1	2
Dates	1	2
Diosgenin	2	2
Elderberry	1	2
Elm tree	1	2
Endocannabinoids	1	2
Ferulic acid	1	2
Fish Oil	1	2
Frankincense	1	2
Galacto-oligosaccharides	1	2
Gardenia	1	2
Genipin	1	2
Geraniol	1	2
Germanium	1	2
Ginseng	1	2
Gymnema Sylvestre	1	2
Holy Basil	1	2
Honokiol	1	2
Horse Chestnut	1	2
Hydrogen Water	1	2
Ice Man Fungus	1	2
Indole-3-Carbinol	1	2
Inulin	1	2
Isoliquiritigenin	1	2
Kiwifruit	1	2
Lactobacillus Acidophilus	1	2
Lactobacillus delbrueckii Subsp	1	2
Lactobacillus reuteri	1	2
Lactoferrin	1	2
Lemon	1	2
Ligustrazine	1	2
Longan	1	2
Loquat	1	2
Loquat Seeds	1	2
Lychee	1	2
Mangifera indica	1	2
Melia azedarach	1	2
Moxibustion	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Mung Bean	1	2
Mushrooms: All	2	2
Noni leaf extract	1	2
Oak	1	2
Okra	1	2
Oleuropein	1	2
P-Coumaric Acid	1	2
Perilla	1	2
Pine Bark Extract	1	2
Pine Buds	1	2
Pine Cone	1	2
Piperine	2	2
Plantago asiatica	2	2
Plantago lanceolata	1	2
Polyunsaturated Fatty Acids (PUFAs)	2	2
Propionibacterium freudenreichii	1	2
Propolis: Bee	1	2
Puerarin	1	2
Punicic acid	1	2
Pycnogenol (Pine Bark)	1	2
Radish	1	2
Rosemaric Acid	1	2
Rutin	1	2
Scutellaria barbata	1	2
Sea Cucumber	1	2
Sesame Seed Oil	1	2
Stigmasterol	1	2
Suma (Pfaffia Paniculata)	1	2
Testosterone	1	2
Thioproline	1	2
Thistle	1	2
Thymol	2	2
Thymus Extract	1	2
Ursolic Acid	2	2
Vaccenic acid	1	2
Vinegar	1	2
Vitamin B-5 (Pantothenic Acid)	1	2
Wogonin	1	2
Woodfordia fruticosa	1	2
Xanthohumol	1	2
Yeast	1	2
Allicin	1	1
Andrographolide	1	1
Antrodia camphorata	1	1
Asiatic Acid	1	1
Asparagus	1	1
Beans: All	1	1
Betulinic acid	1	1
Blue-Green Algae	1	1
Boron	1	1
Broccoli	1	1
Caffeic acid phenethyl ester	1	1
Capsaicin	1	1
Carnosic Acid	1	1
Carpolobia lutea	1	1
Chili pepper	1	1
Crocetin	1	1
Cruciferous Vegetables	1	1
Curry Leaves	1	1
Cycloastragenol	1	1
Durian	1	1
EPA (Eicosapentaenoic Acid)	1	1
Emodin	1	1
Epimedium	1	1
Essential Oils: Unspecified	1	1
Fisetin	1	1
Flaxseed	1	1
Guarana	1	1
Hawthorn	1	1
Jambul	1	1
Linoleic acid	1	1
Lupeol	1	1
Luteolin	1	1
Mango	1	1
Monolaurin	1	1
Paeoniflorin	1	1
Panax Ginseng	1	1
Pelargonium sidoides	1	1
Piperidines	1	1
Plum	1	1
Pomegranate Peel	1	1
Prunella vulgaris	1	1
Psyllium	1	1
Pumpkin	1	1
Pumpkin Seeds	1	1
Rehmannia	1	1
Safranal	1	1
Seaweed: Brown	1	1
Silibinin	1	1
Sodium benzoate (cinnamon metabolite)	1	1
Sorghum	1	1
Soursop	1	1
Soy	1	1
Sweet Cherry	1	1
Tansy	1	1
Thiamine (B-1)	1	1
Tomato	1	1
Triphala	1	1
Turkey Tail Mushroom	1	1
Vitamin A	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin K2	1	1
Walnut	1	1

[+]

Evidence indicates that echinacea potently lowers the risk of recurrent respiratory infections and complications.Feb 28, 2015

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Pubmed Data : Adv Ther. 2015 Mar ;32(3):187-200. Epub 2015 Mar 18. PMID: 25784510

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2019 Dec ;44(23):5174-5183. PMID: 32237355

Article Published Date : Nov 30, 2019

Study Type : Meta Analysis

Additional Links

Substances : Maitake Mushroom

Pharmacological Actions : Immunomodulatory

Additional Keywords : Polysaccharides

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Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination.Dec 31, 2013

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Pubmed Data : J Pharmacol Pharmacother. 2012 Oct ;3(4):300-3. PMID: 23326099

Article Published Date : Oct 01, 2012

Study Type : Meta Analysis

Additional Links

Substances : Vitamin D

Diseases : Respiratory Tract Infections

Pharmacological Actions : Immunomodulatory

Additional Keywords : vaccine alternatives

Anti Therapeutic Actions : Vaccination: All

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Vitamin D supplementation can be considered as a combination therapy in patients with pulmonary tuberculosis.Jun 27, 2018

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Pubmed Data : Complement Ther Med. 2013 Dec ;21(6):660-8. Epub 2013 Sep 13. PMID: 24280475

Article Published Date : Nov 30, 2013

Study Type : Human Study

Additional Links

Diseases : Mood Disorders, Stress

Therapeutic Actions : Laughter/Humor, Qigong

Pharmacological Actions : Immunomodulatory

Additional Keywords : Significant Treatment Outcome

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A maitake mushroom extract has beneficial immunomodulatory potential in patients with myelodysplastic syndromes.Oct 28, 2014

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Pubmed Data : Cancer Immunol Immunother. 2014 Oct 29. Epub 2014 Oct 29. PMID: 25351719

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Pubmed Data : Asian Pac J Cancer Prev. 2013 ;14(6):3903-7. PMID: 23886205

Article Published Date : Dec 31, 2012

Study Type : Human Study

Additional Links

Substances : Ginger

Diseases : Colorectal Cancer

Therapeutic Actions : Aromatherapy Massage

Pharmacological Actions : Immunomodulatory

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Arsenicum album appears to have great potential for ameliorating arsenic induced elevated ANA titer and other hematological toxicities.Feb 28, 2006

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Pubmed Data : Eur J Haematol. 2020 Mar 27. Epub 2020 Mar 27. PMID: 32221992

Article Published Date : Mar 26, 2020

Study Type : Human Study

Additional Links

Diseases : Inflammation

Therapeutic Actions : Exercise: Endurance, Exercise: Resistance Training

Pharmacological Actions : Immunomodulatory

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Changes in transcript, metabolite and antibody reactivity during the early protective immune response in humans to Mycobacterium tuberculosis infection.Aug 14, 2019

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Pubmed Data : Klin Lab Diagn. 2019 ;64(12):753-757. PMID: 32040900

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Lipid Peroxidation, Vitamin D Deficiency

Pharmacological Actions : Antioxidants, Immunomodulatory

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Dimethylglycine has mmunomodulating properties in humans.Nov 01, 2008

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Pubmed Data : Med Sci Sports Exerc. 2008 Nov;40(11):1863-72. PMID: 6163829

Article Published Date : Nov 01, 2008

Study Type : Human Study

Additional Links

Diseases : Immune Disorders: Low Immune Function

Pharmacological Actions : Immunomodulatory

[+]

Direct infant UV light exposure is associated with eczema and immune development.Dec 31, 2018

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Pubmed Data : J Allergy Clin Immunol. 2019 03 ;143(3):1012-1020.e2. Epub 2018 Oct 23. PMID: 30366577

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Eczema, Vitamin D Deficiency

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Risk Reduction

[+]

Ecological evidence for lower risk of lymphoma with greater exposure to sunlight and higher altitude.Feb 29, 2020

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Pubmed Data : High Alt Med Biol. 2020 Mar ;21(1):37-44. Epub 2019 Nov 25. PMID: 31765244

Article Published Date : Feb 29, 2020

[+]

Exercise training can attenuate the inflammatory milieu in women with systemic lupus erythematosus.Sep 14, 2014

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Pubmed Data : J Appl Physiol (1985). 2014 Sep 15 ;117(6):639-47. Epub 2014 Jul 18. PMID: 25038103

Article Published Date : Sep 14, 2014

Study Type : Human Study

Additional Links

Diseases : Systemic Lupus Erythematosus

Therapeutic Actions : Exercise

Pharmacological Actions : Immunomodulatory

[+]

Fermented citrus juice containing heat-killed LP0132 had beneficial effects on symptoms and QOL in patients with atopic dermatitis.Dec 31, 2015

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Pubmed Data : J Transl Med. 2014 ;12:283. Epub 2014 Oct 9. PMID: 25297058

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Pubmed Data : Complement Ther Med. 2013 Oct ;21(5):473-80. Epub 2013 Jul 25. PMID: 24050582

Article Published Date : Sep 30, 2013

Study Type : Human Study

Additional Links

Substances : Evening Primrose Oil, Hemp Seed

Diseases : Inflammation, Multiple Sclerosis: Relapsing-Remitting

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Dietary Modification, Phytotherapy, Plant Extracts

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Hydrolyzed rice bran prevents the common cold syndrome in the elderly based on its immunomodulatory action.Dec 31, 2003

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Pubmed Data : Biofactors. 2004 ;21(1-4):185-7. PMID: 15630195

Ingestion of HOKKAIDO strain yogurt tends to improve immune activity and decrease stress markers.Jun 30, 2016

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Pubmed Data : J Ginseng Res. 2017 Apr ;41(2):222-226. Epub 2017 Jan 6. PMID: 28413328

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N. sativa seed supplementation during specific immunotherapy of allergic rhinitis may be considered a potential adjuvant therapy.Dec 31, 2009

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Pubmed Data : Med Princ Pract. 2010 ;19(3):206-11. Epub 2010 Mar 29. PMID: 20357504

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Pubmed Data : Anticancer Res. 2014 Jul ;34(7):3569-78. PMID: 24982371

Article Published Date : Jun 30, 2014

Study Type : Human Study

Additional Links

Substances : Gc protein-derived macrophage activating factor (GcMAF), Oleic acid

Diseases : Cancers: All

Pharmacological Actions : Immunomodulatory

Additional Keywords : Synergistic

[+]

Oligo-fucoidan improved unbalance the Th1/Th2 and Treg/Th17 ratios in asthmatic patients.Dec 31, 2018

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Pubmed Data : Ter Arkh. 1991;63(11):58-60. PMID: 1810066

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Pubmed Data : Pak J Med Sci. 2019 Nov-Dec;35(6):1538-1543. PMID: 31777489

Article Published Date : Oct 31, 2019

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Pubmed Data : J Allergy Clin Immunol. 2015 Mar ;135(3):737-44.e8. Epub 2015 Jan 13. PMID: 25592987

Article Published Date : Feb 28, 2015

Study Type : Human Study

Additional Links

Substances : Lactobacillus rhamnosus , Probiotics

Diseases : Food Allergies

Pharmacological Actions : Immunomodulatory

Additional Keywords : Significant Treatment Outcome

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Probiotic bacteria can provide specific benefit in HIV infected patients during antiretroviral treatment by improvement of the microbiota and reducing mucosal and systemic inflammation.Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(9):e0137200. Epub 2015 Sep 16. PMID: 26376436

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Probiotics

Diseases : HIV Infections, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Microbiota

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Pubmed Data : Zhong Xi Yi Jie He Za Zhi. 1991 Oct ;11(10):598-9, 580. PMID: 1806305

Article Published Date : Sep 30, 1991

Study Type : Human Study

Additional Links

Substances : Lithospermum erythrorhizon, Shikonin

Diseases : Lung Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Immunomodulatory

[+]

Short meditation intervention in trained subjects may rapidly influence the epigenome at sites of potential relevance for immune function.Jan 31, 2020

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Pubmed Data : Brain Behav Immun. 2020 Feb ;84:36-44. Epub 2019 Nov 13. PMID: 31733290

Article Published Date : Jan 31, 2020

Study Type : Human Study

Additional Links

Therapeutic Actions : Meditation

Pharmacological Actions : Immunomodulatory

Additional Keywords : DNA Methylation, Epigenetic Modification

[+]

Short-term exposure to forest environment may have clinical and immunological effects in children with allergic diseasesJan 31, 2015

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Pubmed Data : Iran J Allergy Asthma Immunol. 2015 Feb ;14(1):28-36. PMID: 25530136

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Pubmed Data : Chiropr Osteopat. 2010 ;18:26. Epub 2010 Sep 8. PMID: 20825650

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Immune Disorders: Low Immune Function

Therapeutic Actions : Chiropractic treatment

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Immunoglobulin G up-regulation, Immunomodulatory: Immunoglobulin M Up-Regulation, Interleukin-2 upregulation

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Substituting EVOO for oils used in a typical American diet may have both cardio-metabolic and immunologic health benefits as indicated by reduced systolic blood pressure.Dec 31, 2014

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Pubmed Data : Aliment Pharmacol Ther. 2020 Jan ;51(1):110-120. Epub 2019 Dec 3. PMID: 31797399

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Bifidobacterium animalis

Diseases : Colic

Pharmacological Actions : Gastrointestinal Agents, Immunomodulatory

[+]

Supplementation with L-theanine seems to exert a beneficial effect on a disrupted Th1/Th2 balance in elite athletes.Feb 14, 2019

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Pubmed Data : J Int Soc Sports Nutr. 2019 Feb 15 ;16(1):7. Epub 2019 Feb 15. PMID: 30770758

Article Published Date : Feb 14, 2019

Study Type : Human Study

Additional Links

Substances : Theanine

Diseases : Athletic Performance, Immune Dysregulation: TH1/TH2 imbalance

Therapeutic Actions : Exercise

Pharmacological Actions : Immunomodulatory, Interleukin-10 downregulation

[+]

Synbiotic therapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients.Oct 28, 2012

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Pubmed Data : Nutr Res Pract. 2016 Aug ;10(4):418-23. Epub 2016 Apr 22. PMID: 27478549

Article Published Date : Jul 31, 2016

Study Type : Human Study

Additional Links

Substances : Spirulina

Diseases : Obesity

Pharmacological Actions : Antioxidants, Hypolipidemic, Immunomodulatory

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The study result suggests that regular structured physical activity improves the inflammatory profile of antiretroviral therapy-treated HIV-infected children.Dec 26, 2019

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Pubmed Data : Pediatr Exerc Sci. 2019 Dec 27:1-8. Epub 2019 Dec 27. PMID: 31881531

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Pubmed Data : Med Drug Discov. 2020 Dec ;8:100064. Epub 2020 Sep 18. PMID: 32964205

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Pubmed Data : Anesteziol Reanimatol. 1989 Jul-Aug(4):31-5. PMID: 2817495

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Pubmed Data : J Exp Bot. 2000 Oct;51(351):1635-45. PMID: 17127471

Article Published Date : Oct 01, 2000

Study Type : Human Study

Additional Links

Substances : Whey

Diseases : Asthma, Asthma: Childhood, Atopic Disease

Pharmacological Actions : Immunomodulatory

[+]

Whey protein supplementation can increase glutathione levels and improve nutritional status and immunity in cancer patients undergoing chemotherapy.May 31, 2018

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Pubmed Data : Biochem Biophys Res Commun. 2016 Jul 25. Epub 2016 Jul 25. PMID: 27462020

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Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2017 Nov 15. Epub 2017 Nov 15. PMID: 29149822

Article Published Date : Nov 14, 2017

Study Type : Human In Vitro

Additional Links

Substances : Olive leaf extract

Diseases : Cardiovascular Diseases, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interferon-gamma (IFN-gamma) inducer

[+]

These data suggest that vitamin C differentially influences intracytoplasmic cytokine production in adults and neonates.Dec 31, 2006

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Pubmed Data : Neonatology. 2007 ;91(1):54-60. Epub 2006 Nov 10. PMID: 17344653

Article Published Date : Dec 31, 2006

Study Type : Human In Vitro

Additional Links

Substances : Vitamin C

Pharmacological Actions : Immunomodulatory

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This study demonstrates a biomolecular effect of GcMAF in BMDMs from autistic patients, providing further evidence for a positive use of this molecule in autism treatment.Dec 31, 2013

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Pubmed Data : J Neuroinflammation. 2014 ;11:78. Epub 2014 Apr 17. PMID: 24739187

Article Published Date : Dec 31, 2013

Study Type : Human In Vitro

Additional Links

Substances : Gc protein-derived macrophage activating factor (GcMAF)

Diseases : Autism Spectrum Disorders

Pharmacological Actions : Immunomodulatory

Additional Keywords : Endocannabinoid System

[+]

This study described the immunomodulatory effects of parsley.May 01, 2012

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Pubmed Data : Expert Rev Clin Immunol. 2012 May ;8(4):295-7. PMID: 22607173

Article Published Date : May 01, 2012

Study Type : Human In Vitro

Additional Links

Substances : Parsley

Pharmacological Actions : Immunomodulatory

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Vitamin C modulated the immune system.Mar 22, 2017

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Pubmed Data : BMC Genomics. 2017 Mar 23 ;18(1):252. Epub 2017 Mar 23. PMID: 28335738

Article Published Date : Mar 22, 2017

Study Type : Human In Vitro

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Substances : Vitamin C

Diseases : Tuberculosis

Pharmacological Actions : Immunomodulatory

Additional Keywords : Gene Expression Regulation

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Vitamin D rescues impaired Mycobacterium tuberculosis-mediated tumor necrosis factor release in macrophages of HIV-seropositive individuals.Dec 31, 2012

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PMID: 24311845

Article Published Date : Dec 31, 2012

Study Type : Human: Case Report

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Substances : Nigella sativa (aka Black Seed)

Diseases : HIV Infections

Pharmacological Actions : Antiviral Agents, Immunomodulatory

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Reduction in obsessive compulsive disorder and self-injurious behaviour with saccharomyces boulardii in a child with autism.Nov 30, 2018

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Pubmed Data : Integr Med (Encinitas). 2018 Dec ;17(6):38-41. PMID: 31043927

Article Published Date : Nov 30, 2018

Study Type : Human: Case Report

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Substances : Saccharomyces Boulardii

Diseases : Autism, Obsessive-Compulsive Disorder

Pharmacological Actions : Antidiarrheals, Gastrointestinal Agents, Immunomodulatory

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The data presented here may indicate that CBD led to a partial tumour response in a patient with histologically proven adenocarcinoma of the lung.Dec 31, 2018

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Pubmed Data : J Agric Food Chem. 2007 Aug 8;55(16):6431-8. Epub 2007 Jul 14. PMID: 17630760

Article Published Date : Aug 08, 2007

Study Type : Animal Study

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Substances : Catechin , Flavonoids, Polyphenols

Diseases : Low Immune Function: Thymus Dysfunction

Pharmacological Actions : Antioxidants, Immunomodulatory

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A cocoa enriched diet produces an immunomodulatory effect that prevents anti-allergen IgE synthesis.May 31, 2012

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Pubmed Data : Pharmacol Res. 2012 Jun ;65(6):603-8. Epub 2012 Feb 10. PMID: 22342543

A fucoidan-supplemented diet can inhibit DMBA-induced tumors in rats.Oct 31, 2017

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Pubmed Data : Nutr Cancer. 2017 Nov-Dec;69(8):1234-1244. Epub 2017 Oct 18. PMID: 29043842

Article Published Date : Oct 31, 2017

Study Type : Animal Study

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Substances : Fucoidan

Diseases : Breast Cancer: Chemically-Induced

Pharmacological Actions : Chemopreventive, Immunomodulatory

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A fungal protein from H. erinaceus could be used as a drug or functional food ingredient for immunotherapy.Dec 31, 2016

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Pubmed Data : Front Immunol. 2017 ;8:666. Epub 2017 Jun 12. PMID: 28713364

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Cancers: All, Inflammatory Bowel Diseases

Pharmacological Actions : Chemotherapeutic, Immunomodulatory

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A germanium compound induces interferon and activates NK cells and macrophages in mice. Nov 01, 1982

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Pubmed Data : Gan To Kagaku Ryoho. 1982 Nov;9(11):1976-80. PMID: 6191691

Article Published Date : Nov 01, 1982

Study Type : Animal Study

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Substances : Germanium

Diseases : Immune Disorders: Low Immune Function

Pharmacological Actions : Immunomodulatory, Interferon Inducers

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A matured fruit extract of date palm tree (Phoenix dactylifera L.) stimulates the cellular immune system in mice.Oct 25, 2011

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Pubmed Data : Iran J Public Health. 2018 Jun ;47(6):838-843. PMID: 30087869

Article Published Date : May 31, 2018

Study Type : Animal Study

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Substances : Adlay

Diseases : Lung Cancer

Pharmacological Actions : Chemotherapeutic, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Immunomodulatory

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

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Adlay bran extract can reduce an allergic reaction by balancing Th1/Th2 immune responses.Sep 30, 2012

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Pubmed Data : Food Chem Toxicol. 2012 Oct ;50(10):3808-13. Epub 2012 Jul 15. PMID: 22809477

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Pubmed Data : J Food Biochem. 2019 Apr ;43(4):e12795. Epub 2019 Feb 21. PMID: 31353605

Article Published Date : Mar 31, 2019

Study Type : Animal Study

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Substances : Allicin

Diseases : Bacterial Infections

Pharmacological Actions : Antimicrobial, Gastrointestinal Agents, Immunomodulatory

Additional Keywords : Gene Expression Regulation, Microbiota

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Allium hookeri root extract regulates asthmatic changes through immunological modulation of Th1/Th2‑related factors in an ovalbumin‑induced asthma.Sep 30, 2019

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Pubmed Data : Springerplus. 2015 ;4:438. Epub 2015 Aug 21. PMID: 26312203

Article Published Date : Dec 31, 2014

Study Type : Animal Study

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Substances : Amla Fruit

Diseases : Arsenic Poisoning, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Arsenic

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Amygdalin (Vitamin B17) pretreatment attenuates experimentally induced acute autoimmune hepatitis.May 14, 2019

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Pubmed Data : Ann Anat. 2019 May 15 ;224:124-132. Epub 2019 May 15. PMID: 31100343

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Pubmed Data : Mediators Inflamm. 2014 ;2014:640746. Epub 2014 Apr 13. PMID: 24829522

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Pubmed Data : Sci Rep. 2018 Jul 12 ;8(1):10523. Epub 2018 Jul 12. PMID: 30002398

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Pubmed Data : Eur J Nutr. 2011 Oct 5. Epub 2011 Oct 5. PMID: 21972007

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View the Evidence: 1443 Abstracts with Immunomodulatory Research

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Evidence indicates that echinacea potently lowers the risk of recurrent respiratory infections and complications.Feb 28, 2015

Garlic supplements may be considered as a treatment option for hypertension, slightly elevated cholesterol, and stimulation of immunity.Jan 31, 2016

Ginsenoside Rg3 for chemotherapy-induced myelosuppression.Dec 31, 2019

Meta-analysis on effect of Grifola frondosa polysaccharide in regulating in vivo immunoregulatory function.Nov 30, 2019

Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination.Dec 31, 2013

Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis.Nov 01, 2016

The favorable effect of probiotic use in the prevention of atopic dermatitis is similar regardless of the time of probiotic use (pregnancy or early life) or the subject(s) receiving probiotics (mother, child, or both).Mar 21, 2012

Vitamin D decreases the events related to respiratory tract infections.Oct 01, 2012

Vitamin D supplementation can be considered as a combination therapy in patients with pulmonary tuberculosis.Jun 27, 2018

Whey protein supplementation raises CD4 cell counts in HIV-positive subjects.Nov 01, 2008

Zinc supplementation boosts the stress response in the elderly.May 01, 2008

A single dose of cholecalcipherol (300,000 IU) combined with standard treatment significantly ameliorates patients general health.Dec 31, 2016

SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels.Dec 31, 2019

The clinical cases presented here reinforce the hypothesis that GcMAF could become part of anticancer immunotherapeutic regimens.Jul 31, 2013

This study demonstrates an association between low levels of serum 25[OH]D and increased orthopaedic infection.Dec 31, 2019

"Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants."Dec 10, 2012

1, 25-dihydroxyvitamin D3 downregulates cytotoxic effector response in pulmonary tuberculosis.Aug 31, 2018

A Bifidobacteria mixture was able of significantly improving allergic rhinitis symptoms.Mar 06, 2017

A combined treatment of Lentinula edodes mycelia and immunotherapy might improve QOL and immunological function in cancer patients.Jun 30, 2016

A formula containing omega-3 fatty acids, arginine and RNA improves outcomes of surgery for esophageal cancer.Nov 01, 2007

A laughing Qigong program is a non-pharmacological and cost-effective means to help adolescents mitigate stresses in their everyday life.Nov 30, 2013

A maitake mushroom extract has beneficial immunomodulatory potential in patients with myelodysplastic syndromes.Oct 28, 2014

A polyphenol and antioxidant rich fruit and vegetable concentrate has therapeutic value in HIV patients due to enhanced proliferation, which could restore disturbances in T-cell homeostasis. Feb 01, 2004

A proprietary extract from the echinacea plant (Echinacea purpurea) enhances systemic immune response during a common cold.Aug 01, 2005

A vegetarian diet improves symptoms of atopic dermatitis in adults. Nov 01, 2001

Acupuncture could adjust the immune function of sepsis patients, improve their immunological indicators and prognoses.Jun 30, 2015

Acute phase proteins and vitamin D seasonal variation in end-stage renal disease patients.Mar 15, 2020

Advanced effect of Moringa oleifera bioconversion by Rhizopus oligosporus on the treatment of atopic dermatitis.Dec 31, 2017

Aerobic training modulates T cell activation in elderly women with knee osteoarthritis.Dec 31, 2015

After 14 to 25 weekly administrations of GcMAF all patients had very low serum Nagalase levels equivalent to those of healthy control, indicating that these patients are tumor-free.Jun 30, 2008

AGE supplementation may enhance immune cell function and may be partly responsible for the reduced severity of colds and flu reported.Jan 31, 2016

Aged garlic extract may be beneficial in preventing the development of chronic diseases associated with low-grade inflammation.Dec 31, 2017

Antibody titers against EBV in MS patients rise after the onset of the disease and indicate that vitamin D3 supplementation could limit augmentation of these titers in MS patients.Feb 28, 2015

Antibody titers for all HPV strains were significantly higher among those with lower vitamin D levels and among younger participants.Jul 14, 2015

Arginine supplementation in total parenteral nutrition improves postoperative cellular immune function of patients with hepatocellular carcinoma after operationJul 01, 2007

Aromatherapy massage could significantly decrease stress and enhance immune function in pregnant women.Sep 30, 2017

Aromatherapy with light Thai massage can be beneficial for the immune systems of cancer patients who are undergoing chemotherapy.Dec 31, 2012

Arsenicum album appears to have great potential for ameliorating arsenic induced elevated ANA titer and other hematological toxicities.Feb 28, 2006

Astragalus has a positive immunomodulatory effect in patients with myasthenia gravia. Apr 01, 2009

Atopic asthmatics might benefit from zinc supplements.Apr 17, 2018

B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder.Mar 01, 2005

Bacillus clausii exerts immuno-modulatory activity in allergic subjects.Mar 31, 2005

Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise.Sep 01, 2013

Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition.Nov 16, 2020

Beneficial effects of Phyllanthus amarus leaves on hangover symptoms.Nov 30, 2019

Beta-glucan, but not vitamin D or placebo, results in significant improvements of natural killer cell numbers.Apr 04, 2020

Bifidobacterium alleviated Guillain-Barré syndrome by regulating Th cells.Jul 31, 2018

Bloodroot and echinacea offset exercise-associated effects of immune activity.Nov 01, 2009

Blueberries exert immunomodulatory effects and attenuate oxidative stress and inflammation in adults with metabolic syndrome.Nov 14, 2017

Broccoli sprout homogenates increases virus-induced peripheral blood NK cell granzyme B production.Dec 31, 2015

Camel milk had a regulatory effect on multiple parameters of inflammatory mediators, immunomodulators, antiapoptosis, and antioxidants.Oct 31, 2015

Cannabis could be potentially beneficial reduction in systemic inflammation and immune activation in the context of antiretroviral-treated HIV infection.Feb 16, 2018

Cellular immune response to acute exercise: Comparison of endurance and resistance exercise.Mar 26, 2020

Changes in transcript, metabolite and antibody reactivity during the early protective immune response in humans to Mycobacterium tuberculosis infection.Aug 14, 2019

Changing of fecal flora and clinical effect of L. salivarius LS01 in adults with atopic dermatitis.Sep 30, 2012

Children with measles studied in this New York City outbreak had lower vitamin A levels and were more likely to have a high fever for more than 7 days, be hospitalized, have lower measles antibodies, and increased morbidity. Feb 01, 1992

Citrus juice fermented with Lactobacillus plantarum YIT 0132 alleviates symptoms of perennial allergic rhinitisSep 15, 2016

Consumption of yoghurt fermented with L. bulgaricus OLL1073R-1 augmented natural killer cell activity and reduced the risk of catching the common cold in elderly individuals.Oct 01, 2010

Continual intake of a probiotic drink containing Lactobacillus brevis led to a reduction in the incidence of influenza, especially in subjects not inoculated with influenza vaccine.Nov 30, 2014

Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitisApr 30, 2020

Cucurbitacin B significantly reduced the frequency of immature myeloid cells in patients with lung cancers.Sep 30, 2012

Curcumin has strong antioxidant, with anti-inflammatory, immunomodulatory and analgesic properties.Jun 30, 2014

Curcumin was demonstrated to be effective as an adjuvant therapy for the treatment of psoriasis vulgaris and to significantly reduce serum levels of IL-22.Dec 31, 2014

Daily supplementation with S. platensis to diet combined with a reasonable balanced diet has significantly increased the CD4 cells and reduced the viral load after 6 months.Dec 31, 2014

Data suggest that measurable health advantages are associated with vitamin C supplementation in men with adequate to low vitamin C status.Jun 30, 2014

Determination of plasma and leukocyte vitamin C concentrations in a randomized, double-blind, placebo-controlled trial with Ester-C.Dec 31, 2015

Determination of some indicators of immunity and lipoperoxidation in the oral fluid in persons with a low vitamin D level.Dec 31, 2018

Dimethylglycine has mmunomodulating properties in humans.Nov 01, 2008

Direct infant UV light exposure is associated with eczema and immune development.Dec 31, 2018

Ecological evidence for lower risk of lymphoma with greater exposure to sunlight and higher altitude.Feb 29, 2020

Effect of moderate exercise under hypoxia on Th1/Th2 cytokine balance.Jul 15, 2019

Effect of oral N-acetylcysteine supplementation on the immunity system in patients with acute myocardial infarction.Sep 30, 2019

Immunomodulatory

View the Evidence:
1443 Abstracts with Immunomodulatory Research