Immunomodulatory

Name	AC	CK
Vitamin D	126	435
Probiotics	56	206
Vitamin C	65	157
Curcumin	73	140
Lactobacillus plantarum	24	88
Yoghurt	11	77
Selenium	22	75
Echinacea	22	74
Fermented Foods and Beverages	16	73
Ginsenosides	29	59
Beta-glucan	13	53
Zinc	21	52
Maitake Mushroom	16	51
Polyphenols	16	51
Garlic	13	47
Whey	4	41
Gc protein-derived macrophage activating factor (GcMAF)	6	39
Bifidobacterium Infantis	7	38
EGCG (Epigallocatechin gallate)	22	34
Fucoidan	12	34
Lactobacillus paracasei	5	34
Nigella sativa (aka Black Seed)	12	33
Fruit: All	4	31
Ginseng (Korean)	9	31
Omega-3 Fatty Acids	11	31
Bifidobacterium Longum	8	30
Vitamin E	16	29
Lactobacillus rhamnosus	6	28
Oligosaccharides	10	28
Resveratrol	20	28
Spirulina	9	28
Lactobacillus casei	10	27
Cannabidiol	16	26
Flavonoids	14	26
Bee Venom	10	25
Bifidobacterium animalis	5	25
Shiitake Mushroom	11	25
Arginine	4	24
Bifidobacterium Bifidum	4	24
Moringa oleifera	10	24
Reishi Mushroom	12	24
Turmeric	9	23
Cannabis	8	22
Evening Primrose Oil	3	22
Garlic: Aged	3	22
Iodine	3	22
Lactobacillus reuteri	7	22
Lactobacillus rhamnosus GG	8	22
Melatonin	17	22
Riboflavin (Vitamin B-2)	4	22
Vitamin A	12	22
Glutathione	3	21
Lactobacillus helveticus	3	21
Pantothenic Acid (Vitamin B-5)	3	21
Apigenin	12	20
Homeopathic Medicine: All	6	20
Vegetables: All	2	20
Astragalus	8	19
Ginger	8	19
Lactobacillus fermentum	6	19
Lactoferrin	16	19
NAC (N-acetyl-L-cysteine)	7	19
Lactobacillus probiotics	6	18
Chokeberry	5	17
Papaya: Fermented	3	17
Polyunsaturated Fatty Acids (PUFAs)	7	17
Royal Jelly	6	17
Anthocyanins	5	16
Berberine	12	16
Medicinal Mushrooms	13	16
Shikonin	5	16
Bee Propolis	5	15
Blueberry	4	15
Fiber	4	15
Fish Oil	4	15
Goji	5	15
Grape	5	15
Guduchi	5	15
Paeoniflorin	12	15
Rice Bran	5	15
Thymoquinone	11	15
Cannabinoids	5	14
Lactobacillus Acidophilus	3	14
Astaxanthin	7	13
Chaga Mushroom (Inonotus obliquus)	7	13
Chlorella (Algae)	3	13
Delta-tetrahydrocannabinol (THC)	8	13
Modified Arabinoxylan Rice Bran (MGN-3)	3	13
Peony	9	13
Prebiotics	9	13
Quercetin	10	13
Sea buckthorn	3	13
Bacillus Clausii	3	12
Bromelain	3	12
Hemp Seed	2	12
Lion's Mane (Hericium Erinaceus)	8	12
Mangiferin	8	12
Vitamin B-6	3	12
White Button Mushroom	2	12
Broccoli Sprouts	2	11
Carotenoids	2	11
Cucurbitacin B	2	11
Genistein	7	11
Green Tea	6	11
Lactobacillus Brevis	2	11
Lactobacillus salivarius	2	11
Noni	6	11
Theanine	2	11
Vitamin C: Intravenous	2	11
Alternanthera pungens	1	10
Apple	1	10
Bifidobacterium Lactis	1	10
Bloodroot	1	10
Camel Milk	1	10
Coenzyme Q10	1	10
Glycyrrhiza uralensis	1	10
Homeopathic Arsenicum album	1	10
Infection/Infectitious Agent Byproducts (Beneficial)	1	10
L-Carnitine	1	10
Lactobacilius bulgaricus	1	10
Lactobacillus casei: Shirota	1	10
Lithospermum erythrorhizon	1	10
Naringenin	7	10
Oleic acid	1	10
Olive Oil	1	10
Oyster Mushroom	1	10
Pantethine	1	10
Phyllanthus amarus	1	10
Ribonucleic acid (RNA)	1	10
Tongkat Ali	1	10
Agaricus Blazei	5	9
Ashwagandha	4	9
Astragaloside	6	9
Elderberry	3	9
Licorice	6	9
Mistletoe	5	9
Phloretin	6	9
Sulforaphane	6	9
Aloe Vera	6	8
Honey	7	8
Onion	4	8
Tanshinone IIA	5	8
Bitter Melon	4	7
Fig	4	7
Hesperidin	4	7
Olive leaf extract	3	7
Oridonin	4	7
Purslane	5	7
Adlay	4	6
Andrographis	4	6
Arctigenin	4	6
Cordyceps Militaris	4	6
Ginseng	5	6
Glutamine	3	6
Honeysuckle	4	6
Papaya	4	6
Parsley	2	6
St. Johns Wort	4	6
Vitamin E: alpha tocopherol	3	6
Baicalein	3	5
Bamboo	3	5
Burdock	3	5
Dandelion	3	5
Frankincense	2	5
Ginseng (Siberian)	3	5
Kefir	3	5
Lactococcus lactis	4	5
Lotus	3	5
Luteolin	4	5
Milk: Fermented	3	5
Parthenolide	3	5
Plantago	3	5
Pomegranate	4	5
Poria cocos	4	5
Saffron	4	5
Thiamine (B-1)	4	5
Zataria multiflora	3	5
Zerumbone	4	5
Artesunate	2	4
Bai Zhu	2	4
Black Pepper	2	4
Black Raspberry	2	4
Caffeic acid phenethyl ester	3	4
Carvacrol	2	4
DHA (Docosahexaenoic Acid)	2	4
Daidzein	2	4
Gingerol	3	4
Gynostemma	3	4
Hydrogen Water	2	4
Indole-3-Carbinol	2	4
Lactobacillus delbrueckii Subsp	2	4
Lupeol	3	4
Okra	2	4
Phellinus Linteus	3	4
Piperine	3	4
Prunella vulgaris	3	4
Puerarin	2	4
Raspberry	2	4
Sweet Potato: Purple	2	4
Ursolic Acid	3	4
Allicin	2	3
Bael	2	3
Banana	2	3
Bifidobacterium Breve	2	3
Bisdemethoxycurcumin	2	3
Black Currant	2	3
Blue Honeysuckle	2	3
Butyrate	2	3
Carnosol	2	3
Cinnamon	2	3
Cocoa	2	3
Coconut Oil	2	3
D-Mannose	3	3
EPA (Eicosapentaenoic Acid)	2	3
Emodin	3	3
Eriodictyol	2	3
Eugenol	2	3
Fisetin	2	3
Gallic Acid	2	3
Jujube	2	3
Kanuka Honey	1	3
Myricetin	2	3
Paeonol	2	3
Prickly Pear Cactus	2	3
Rutin	2	3
Saccharomyces Boulardii	1	3
Silver (nanoparticles)	2	3
Thyme	2	3
Turkey Tail Mushroom	3	3
Verbascoside	2	3
Walnut	2	3
White Mulberry	2	3
Wogonin	2	3
Acacia catechu	1	2
Acetic Acid	1	2
Algae	1	2
Alpha Linolenic Acid	1	2
Amla Fruit	1	2
Amygdalin (laetrile)	1	2
Anandamide	1	2
Angelica	1	2
Antrodia camphorata	2	2
Apples	1	2
Artichoke	1	2
Asparagus	2	2
Babchi	1	2
Barberry	1	2
Basil	1	2
Beta-Caryophyllene	1	2
Beta-Elemene	1	2
Black Tea	1	2
Bufalin	1	2
Cardamom	1	2
Carrageenans	1	2
Cat's Claw	2	2
Catechin	1	2
Celastrol	1	2
Chinese Skullcap	1	2
Chrysin	2	2
Cinnamaldehyde	1	2
Coconut	1	2
Codonopsis pilosula	1	2
Common bean	1	2
Cordyceps sinensis	1	2
Coriolus versicolor	1	2
Coumestrol	1	2
Cranberry	1	2
Crocetin	2	2
Crocin	2	2
Cucurbitacin E	1	2
Cumin	1	2
Dates	1	2
Diallyl sulfide	1	2
Diosgenin	2	2
Elm tree	1	2
Endocannabinoids	1	2
Eucalyptus	1	2
FOS (Fructooligosaccharides)	1	2
Ferulic acid	1	2
Fruit Peel	1	2
Galacto-oligosaccharides	1	2
Galactooligosaccharides	1	2
Gardenia	1	2
Genipin	1	2
Geraniol	1	2
Germanium	1	2
Ginseng (American)	2	2
Glycyrrhizin	2	2
Gymnema Sylvestre	1	2
Hawthorn	2	2
Holy Basil	1	2
Honokiol	1	2
Hops	1	2
Horse Chestnut	1	2
Horsetail	1	2
Ice Man Fungus	1	2
Inulin	1	2
Iron	2	2
Isoliquiritigenin	1	2
Kiwifruit	1	2
Kombucha Tea	2	2
Lactobacillus sakei	1	2
Lemon	1	2
Ligustrazine	1	2
Liquiritigenin	1	2
Longan	1	2
Loquat	1	2
Loquat Seeds	1	2
Lupine	1	2
Lychee	1	2
Lycopene	1	2
Magnesium	2	2
Mangifera indica	1	2
Mangosteen	1	2
Melia azedarach	1	2
Motherwort	1	2
Moxibustion	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Mung Bean	1	2
Mushrooms: All	2	2
Noni leaf extract	1	2
Oak	1	2
Oleanolic acid	1	2
Oleuropein	1	2
Olive	1	2
Orthosiphon	1	2
P-Coumaric Acid	1	2
Peanut	1	2
Perilla	1	2
Persimmon	1	2
Pine Bark Extract	1	2
Pine Buds	1	2
Pine Cone	1	2
Plantago asiatica	2	2
Plantago lanceolata	1	2
Propionibacterium freudenreichii	1	2
Propolis: Bee	1	2
Punicic acid	1	2
Pycnogenol (Pine Bark)	1	2
Radish	1	2
Rose	2	2
Rosemaric Acid	1	2
Rosemary	2	2
Safflower	1	2
Scutellaria barbata	1	2
Sea Cucumber	1	2
Seaweed	1	2
Sesame Seed Oil	1	2
Silymarin	2	2
Stigmasterol	1	2
Streptococcus thermophilus	1	2
Suma (Pfaffia Paniculata)	1	2
Tarragon	1	2
Testosterone	1	2
Thioproline	1	2
Thistle	1	2
Thymol	2	2
Thymus Extract	1	2
Triphala	2	2
Vaccenic acid	1	2
Vinegar	1	2
Viruses: Beneficial	2	2
Vitamin B-12	2	2
Vitamin B-5 (Pantothenic Acid)	1	2
Woodfordia fruticosa	1	2
Xanthohumol	1	2
Yeast	1	2
beta-Carotene	2	2
neohesperidin	1	2
Alpha-Lipoic Acid	1	1
Andrographolide	1	1
Antioxidant formulas	1	1
Apricot	1	1
Asiatic Acid	1	1
Beans: All	1	1
Beta Sitosterol	1	1
Betulinic acid	1	1
Bifidobacterium	1	1
Bitter Orange	1	1
Blue-Green Algae	1	1
Boron	1	1
Broccoli	1	1
Capsaicin	1	1
Carnosic Acid	1	1
Carpolobia lutea	1	1
Chia	1	1
Chili pepper	1	1
Chlorogenic Acid	1	1
Chrysanthemum Indicum	1	1
Cod Liver Oil	1	1
Copper	1	1
Cruciferous Vegetables	1	1
Curry Leaves	1	1
Cycloastragenol	1	1
Dragon Fruit	1	1
Durian	1	1
Ellagic Acid	1	1
Enterococcus faecium	1	1
Epimedium	1	1
Essential Oils: Unspecified	1	1
Feverfew	1	1
Flaxseed	1	1
Folate	1	1
Formononetin	1	1
Fructans	1	1
Fucoxanthin	1	1
Guarana	1	1
Henna	1	1
Isothiocyanates	1	1
Jambul	1	1
Japanese mugwort	1	1
Lentinan	1	1
Lignans	1	1
Linoleic acid	1	1
Lysergic Acid Diethylamide (LSD)	1	1
Magnolol	1	1
Mango	1	1
Manuka Honey	1	1
Monolaurin	1	1
Mustard: Field/Turnip	1	1
Myo-inositol	1	1
Myrrh	1	1
Neem	1	1
Panax Ginseng	1	1
Pelargonium sidoides	1	1
Piperidines	1	1
Plum	1	1
Pomegranate Peel	1	1
Psychedelics:All	1	1
Psyllium	1	1
Pumpkin	1	1
Pumpkin Seeds	1	1
Quince	1	1
Quinic acid	1	1
Quinoa	1	1
Red Wine Extract	1	1
Rehmannia	1	1
Safranal	1	1
Seaweed: Brown	1	1
Sesame Seeds	1	1
Sesamin	1	1
Silibinin	1	1
Sodium benzoate (cinnamon metabolite)	1	1
Sorghum	1	1
Soursop	1	1
Soy	1	1
Strawberry	1	1
Sweet Cherry	1	1
Tansy	1	1
Tomato	1	1
Toona sinensis	1	1
Vitamin E: Gamma-tocotrienol	1	1
Vitamin K2	1	1
Wheat Germ	1	1
White Tea	1	1
Wormwood	1	1

[+]

Acupuncture can be a possible treatment for respiratory diseases through its modulation of various cytokines, leading to reduced inflammation.Dec 31, 2021

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Pubmed Data : Nutr Clin Pract. 2021 Apr ;36(2):368-384. Epub 2020 Oct 9. PMID: 33037694

Article Published Date : Mar 31, 2021

Study Type : Meta Analysis, Review

Additional Links

Substances : Vitamin D

Diseases : Pneumonia

Pharmacological Actions : Immunomodulatory

[+]

Evidence indicates that echinacea potently lowers the risk of recurrent respiratory infections and complications.Feb 28, 2015

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Pubmed Data : Adv Ther. 2015 Mar ;32(3):187-200. Epub 2015 Mar 18. PMID: 25784510

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Pubmed Data : Thyroid. 2016 Nov 2. Epub 2016 Nov 2. PMID: 27702392

Article Published Date : Nov 01, 2016

Study Type : Meta Analysis, Review

Additional Links

Substances : Selenium

Diseases : Autoimmune Thyroiditis

Pharmacological Actions : Immunomodulatory

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Vitamin D supplementation can be considered as a combination therapy in patients with pulmonary tuberculosis.Jun 27, 2018

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Pubmed Data : Cytotherapy. 2021 03 ;23(3):242-255. Epub 2021 Jan 15. PMID: 33461863

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Diabetes Mellitus: Type 1: Prevention

Pharmacological Actions : Immunomodulatory

Additional Keywords : Epigenetic Modification, Gene Expression Regulation

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A Bifidobacteria mixture was able of significantly improving allergic rhinitis symptoms.Mar 06, 2017

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Pubmed Data : Complement Ther Med. 2013 Dec ;21(6):660-8. Epub 2013 Sep 13. PMID: 24280475

Article Published Date : Nov 30, 2013

Study Type : Human Study

Additional Links

Diseases : Mood Disorders, Stress

Therapeutic Actions : Laughter/Humor, Qigong

Pharmacological Actions : Immunomodulatory

Additional Keywords : Significant Treatment Outcome

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A maitake mushroom extract has beneficial immunomodulatory potential in patients with myelodysplastic syndromes.Oct 28, 2014

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Pubmed Data : Cancer Immunol Immunother. 2014 Oct 29. Epub 2014 Oct 29. PMID: 25351719

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Pubmed Data : Hum Vaccin Immunother. 2015 Jul 15:0. Epub 2015 Jul 15. PMID: 26176493

Article Published Date : Jul 14, 2015

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Pubmed Data : Asian Pac J Cancer Prev. 2013 ;14(6):3903-7. PMID: 23886205

Article Published Date : Dec 31, 2012

Study Type : Human Study

Additional Links

Substances : Ginger

Diseases : Colorectal Cancer

Therapeutic Actions : Aromatherapy Massage

Pharmacological Actions : Immunomodulatory

[+]

Arsenicum album appears to have great potential for ameliorating arsenic induced elevated ANA titer and other hematological toxicities.Feb 28, 2006

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Pubmed Data : Eur J Haematol. 2020 Mar 27. Epub 2020 Mar 27. PMID: 32221992

Article Published Date : Mar 26, 2020

Study Type : Human Study

Additional Links

Diseases : Inflammation

Therapeutic Actions : Exercise: Endurance, Exercise: Resistance Training

Pharmacological Actions : Immunomodulatory

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Changes in transcript, metabolite and antibody reactivity during the early protective immune response in humans to Mycobacterium tuberculosis infection.Aug 14, 2019

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Pubmed Data : Klin Lab Diagn. 2019 ;64(12):753-757. PMID: 32040900

Article Published Date : Dec 31, 2018

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Lipid Peroxidation, Vitamin D Deficiency

Pharmacological Actions : Antioxidants, Immunomodulatory

[+]

Dimethylglycine has mmunomodulating properties in humans.Nov 01, 2008

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Pubmed Data : Med Sci Sports Exerc. 2008 Nov;40(11):1863-72. PMID: 6163829

Article Published Date : Nov 01, 2008

Study Type : Human Study

Additional Links

Diseases : Immune Disorders: Low Immune Function

Pharmacological Actions : Immunomodulatory

[+]

Diospyros peregrina fruit preparation mediated immunomodulation of lymphocytes isolated from the blood of breast cancer patients.Dec 31, 2020

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Pubmed Data : Iran J Immunol. 2021 06 ;18(2):111-118. PMID: 34190692

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Persimmon

Diseases : Breast Cancer

Pharmacological Actions : Immunomodulatory

Additional Keywords : Gene Expression Regulation

[+]

Direct infant UV light exposure is associated with eczema and immune development.Dec 31, 2018

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Pubmed Data : J Allergy Clin Immunol. 2019 03 ;143(3):1012-1020.e2. Epub 2018 Oct 23. PMID: 30366577

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Pubmed Data : Biomed Res Int. 2019 ;2019:3548396. Epub 2019 Apr 11. PMID: 31111049

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Pubmed Data : J Transl Med. 2014 ;12:283. Epub 2014 Oct 9. PMID: 25297058

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Pubmed Data : Complement Ther Med. 2013 Oct ;21(5):473-80. Epub 2013 Jul 25. PMID: 24050582

Article Published Date : Sep 30, 2013

Study Type : Human Study

Additional Links

Substances : Evening Primrose Oil, Hemp Seed

Diseases : Inflammation, Multiple Sclerosis: Relapsing-Remitting

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Dietary Modification, Phytotherapy, Plant Extracts

[+]

High dose intravenous vitamin C for preventing the disease aggravation of moderate COVID-19 pneumonia.Dec 31, 2020

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Pubmed Data : J Pediatr Endocrinol Metab. 2020 May 26 ;33(5):613-621. PMID: 32352398

Article Published Date : May 25, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin D

Pharmacological Actions : Immunomodulatory

[+]

High-fiber dietary supplementation decreased the markers of bone erosion in rheumatoid arthritis patients.Oct 06, 2019

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Pubmed Data : Nutrients. 2019 Oct 7 ;11(10). Epub 2019 Oct 7. PMID: 31591345

Article Published Date : Oct 06, 2019

Study Type : Human Study

Additional Links

Substances : Fiber

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Immunomodulatory

Additional Keywords : Gut-joint axis

[+]

Hydrolyzed rice bran prevents the common cold syndrome in the elderly based on its immunomodulatory action.Dec 31, 2003

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Pubmed Data : Biofactors. 2004 ;21(1-4):185-7. PMID: 15630195

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Pubmed Data : Int J Environ Res Public Health. 2021 Jun 17 ;18(12). Epub 2021 Jun 17. PMID: 34204400

Article Published Date : Jun 16, 2021

Study Type : Human Study

Additional Links

Diseases : Depression

Therapeutic Actions : Exercise

Pharmacological Actions : Immunomodulatory

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Pubmed Data : J Pediatr. 2018 12 ;203:416-422.e1. Epub 2018 Sep 20. PMID: 30243543

Article Published Date : Jan 11, 2018

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Bronchiolitis, Vitamin D Deficiency

Pharmacological Actions : Immunomodulatory

Additional Keywords : Increased Risk

[+]

Ingestion of HOKKAIDO strain yogurt tends to improve immune activity and decrease stress markers.Jun 30, 2016

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Pubmed Data : J Ginseng Res. 2017 Apr ;41(2):222-226. Epub 2017 Jan 6. PMID: 28413328

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Mumps parotitis may lead to expression and immune recognition of a tumor-associated form of MUC1 and create effective immune surveillance of ovarian cancer cells that express this form of MUC1.Aug 01, 2010

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Pubmed Data : Anticancer Res. 2014 Jul ;34(7):3569-78. PMID: 24982371

Article Published Date : Jun 30, 2014

Study Type : Human Study

Additional Links

Substances : Gc protein-derived macrophage activating factor (GcMAF), Oleic acid

Diseases : Cancers: All

Pharmacological Actions : Immunomodulatory

Additional Keywords : Synergistic

[+]

Oligo-fucoidan improved unbalance the Th1/Th2 and Treg/Th17 ratios in asthmatic patients.Dec 31, 2018

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Pubmed Data : Pak J Med Sci. 2019 Nov-Dec;35(6):1538-1543. PMID: 31777489

Article Published Date : Oct 31, 2019

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Pubmed Data : J Allergy Clin Immunol. 2015 Mar ;135(3):737-44.e8. Epub 2015 Jan 13. PMID: 25592987

Article Published Date : Feb 28, 2015

Study Type : Human Study

Additional Links

Substances : Lactobacillus rhamnosus , Probiotics

Diseases : Food Allergies

Pharmacological Actions : Immunomodulatory

Additional Keywords : Significant Treatment Outcome

[+]

Probiotic bacteria can provide specific benefit in HIV infected patients during antiretroviral treatment by improvement of the microbiota and reducing mucosal and systemic inflammation.Dec 31, 2014

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Pubmed Data : PLoS One. 2015 ;10(9):e0137200. Epub 2015 Sep 16. PMID: 26376436

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Probiotics

Diseases : HIV Infections, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Microbiota

[+]

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Pubmed Data : Zhong Xi Yi Jie He Za Zhi. 1991 Oct ;11(10):598-9, 580. PMID: 1806305

Article Published Date : Sep 30, 1991

Study Type : Human Study

Additional Links

Substances : Lithospermum erythrorhizon, Shikonin

Diseases : Lung Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Immunomodulatory

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Short meditation intervention in trained subjects may rapidly influence the epigenome at sites of potential relevance for immune function.Jan 31, 2020

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Pubmed Data : Brain Behav Immun. 2020 Feb ;84:36-44. Epub 2019 Nov 13. PMID: 31733290

Article Published Date : Jan 31, 2020

Study Type : Human Study

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Therapeutic Actions : Meditation

Pharmacological Actions : Immunomodulatory

Additional Keywords : DNA Methylation, Epigenetic Modification

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Short-term exposure to forest environment may have clinical and immunological effects in children with allergic diseasesJan 31, 2015

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Pubmed Data : Iran J Allergy Asthma Immunol. 2015 Feb ;14(1):28-36. PMID: 25530136

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Pubmed Data : Chiropr Osteopat. 2010 ;18:26. Epub 2010 Sep 8. PMID: 20825650

Article Published Date : Jan 01, 2010

Study Type : Human Study

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Diseases : Immune Disorders: Low Immune Function

Therapeutic Actions : Chiropractic treatment

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Immunoglobulin G up-regulation, Immunomodulatory: Immunoglobulin M Up-Regulation, Interleukin-2 upregulation

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Substituting EVOO for oils used in a typical American diet may have both cardio-metabolic and immunologic health benefits as indicated by reduced systolic blood pressure.Dec 31, 2014

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Pubmed Data : Aliment Pharmacol Ther. 2020 Jan ;51(1):110-120. Epub 2019 Dec 3. PMID: 31797399

Article Published Date : Dec 31, 2019

Study Type : Human Study

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Substances : Bifidobacterium animalis

Diseases : Colic

Pharmacological Actions : Gastrointestinal Agents, Immunomodulatory

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Supplementation with L-theanine seems to exert a beneficial effect on a disrupted Th1/Th2 balance in elite athletes.Feb 14, 2019

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Pubmed Data : J Int Soc Sports Nutr. 2019 Feb 15 ;16(1):7. Epub 2019 Feb 15. PMID: 30770758

Article Published Date : Feb 14, 2019

Study Type : Human Study

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Substances : Theanine

Diseases : Athletic Performance, Immune Dysregulation: TH1/TH2 imbalance

Therapeutic Actions : Exercise

Pharmacological Actions : Immunomodulatory, Interleukin-10 downregulation

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Synbiotic therapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients.Oct 28, 2012

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Pubmed Data : ScientificWorldJournal. 2014 ;2014:898361. Epub 2014 Feb 11. PMID: 24678280

Article Published Date : Dec 31, 2013

Study Type : Human Study

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Substances : Curcumin

Diseases : Obesity

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-1 beta downregulation, Interleukin-4 downregulation, VEGFR3 inhibition

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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The results indicate that repetitive mild hyperthermia treatment might suppress excessive sympathetic dominance and modify immunity.Dec 31, 2014

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Pubmed Data : Biomed Res. 2015 ;36(2):135-42. PMID: 25876664

Article Published Date : Dec 31, 2014

Study Type : Human Study

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Therapeutic Actions : Sauna Therapy

Pharmacological Actions : Central Nervous System Depressants, Immunomodulatory, Immunomodulatory: Innate Immunity Up-Regulation

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Pubmed Data : Food Nutr Res. 2016 ;60:32963. Epub 2016 Nov 24. PMID: 27887663

Article Published Date : Dec 31, 2015

Study Type : Human Study

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Substances : Royal Jelly

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Immunomodulatory

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These results suggest that acute exercise could be used to offset mucosal associated invariant T cell deficiencies observed with certain pathologies.Aug 31, 2017

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Pubmed Data : Eur J Appl Physiol. 2017 Sep 1. Epub 2017 Sep 1. PMID: 28864849

Article Published Date : Aug 31, 2017

Study Type : Human Study

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Therapeutic Actions : Exercise: Aerobic

Pharmacological Actions : Immunomodulatory

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Third-trimester high-dose vitD3 supplementation in healthy pregnant women had balanced effects on biomarkers of cord blood Th1 and Th2 responses.Dec 31, 2015

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Pubmed Data : Nutr J. 2016 ;15(1):75. Epub 2016 Aug 9. PMID: 27506771

Article Published Date : Dec 31, 2015

Study Type : Human Study

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Substances : Vitamin D

Pharmacological Actions : Immunomodulatory

Additional Keywords : Gene Expression Regulation

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This pilot study found low serum levels of vitamin C and vitamin D in most of our critically ill COVID-19 ICU patients.Nov 30, 2020

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Pubmed Data : Med Drug Discov. 2020 Dec ;8:100064. Epub 2020 Sep 18. PMID: 32964205

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Pubmed Data : Anesteziol Reanimatol. 1989 Jul-Aug(4):31-5. PMID: 2817495

Pubmed Data : Immunopharmacol Immunotoxicol. 1997 Aug ;19(3):291-312. PMID: 9248859

Article Published Date : Jul 31, 1997

Study Type : Human Study

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Substances : Vitamin C

Pharmacological Actions : Immunomodulatory, Immunostimulatory

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Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease.Jan 25, 2022

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Pubmed Data : BMJ. 2022 01 26 ;376:e066452. Epub 2022 Jan 26. PMID: 35082139

Article Published Date : Jan 25, 2022

Study Type : Human Study

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Substances : Omega-3 Fatty Acids, Vitamin D

Diseases : Autoimmune Diseases

Pharmacological Actions : Immunomodulatory

Additional Keywords : Risk Reduction

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Vitamin D and upper respiratory tract infections in young active males exposed to cold environments.Sep 15, 2021

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Pubmed Data : J Infect Dis. 2022 09 21 ;226(6):949-957. PMID: 35780325

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Pubmed Data : Free Radic Res. 2008 Mar ;42(3):272-80. PMID: 18344122

Article Published Date : Feb 29, 2008

Study Type : Human Study

Additional Links

Substances : Vitamin E

Diseases : Aging

Pharmacological Actions : Antioxidants, Immunomodulatory, Immunostimulatory

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Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-γ-mediated immune activation.Oct 13, 2014

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Pubmed Data : Cancer. 2015 Sep 1 ;121(17):2942-50. Epub 2015 May 18. PMID: 25989179

Article Published Date : Aug 31, 2015

Study Type : Human Study

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Substances : White Button Mushroom

Diseases : Prostate Cancer

Pharmacological Actions : Antineoplastic Agents, Immunomodulatory

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Yogic practices have rapid effects at the molecular level in circulating immune cells.Dec 31, 2012

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Pubmed Data : Front Pharmacol. 2021 ;12:757666. Epub 2021 Oct 25. PMID: 34759825

Article Published Date : Dec 31, 2020

Study Type : Human In Vitro

Additional Links

Substances : Geranium

Diseases : Coronavirus Infection

Pharmacological Actions : Antiviral Agents, Immunomodulatory, interleukin-13 down-regulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor A Inhibitor

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Bellis perennis extract mitigates UVA-induced keratinocyte damage.Jul 31, 2021

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Pubmed Data : J Photochem Photobiol B. 2021 Aug ;221:112247. Epub 2021 Jun 19. PMID: 34175580

Article Published Date : Jul 31, 2021

Study Type : Human In Vitro

Additional Links

Substances : Daisy

Diseases : Ultraviolet Radiation Induced Damage

Therapeutic Actions : Sunlight exposure

Pharmacological Actions : Antioxidants, Immunomodulatory, Photoprotective

Additional Keywords : Plant Extracts

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Elderberry and elderflower extracts inhibit nitric oxide production in lipopolysaccharide-activated macrophages.Mar 08, 2017

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Pubmed Data : Int J Mol Sci. 2017 Mar 8 ;18(3). Epub 2017 Mar 8. PMID: 28282861

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View the Evidence: 1953 Abstracts with Immunomodulatory Research

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Acupuncture can be a possible treatment for respiratory diseases through its modulation of various cytokines, leading to reduced inflammation.Dec 31, 2021

The effects of apigenin administration on the inhibition of inflammatory responses and oxidative stress in the lung injury models.Jun 03, 2022

Bioactive compounds from kefir and their potential benefits on health.Dec 31, 2020

Efficacy of high-dose vitamin D supplementation as an adjuvant treatment on pneumonia.Mar 31, 2021

Evidence indicates that echinacea potently lowers the risk of recurrent respiratory infections and complications.Feb 28, 2015

Garlic supplements may be considered as a treatment option for hypertension, slightly elevated cholesterol, and stimulation of immunity.Jan 31, 2016

Ginsenoside Rg3 for chemotherapy-induced myelosuppression.Dec 31, 2019

Horticultural therapy for general health in the older adults.Dec 31, 2021

Meta-analysis on effect of Grifola frondosa polysaccharide in regulating in vivo immunoregulatory function.Nov 30, 2019

Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination.Dec 31, 2013

Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis.Nov 01, 2016

The effects of Tai chi and Qigong on immune responses.Jun 29, 2020

The favorable effect of probiotic use in the prevention of atopic dermatitis is similar regardless of the time of probiotic use (pregnancy or early life) or the subject(s) receiving probiotics (mother, child, or both).Mar 21, 2012

Vitamin D decreases the events related to respiratory tract infections.Oct 01, 2012

Vitamin D supplementation can be considered as a combination therapy in patients with pulmonary tuberculosis.Jun 27, 2018

Whey protein supplementation raises CD4 cell counts in HIV-positive subjects.Nov 01, 2008

Zinc supplementation boosts the stress response in the elderly.May 01, 2008

A single dose of cholecalcipherol (300,000 IU) combined with standard treatment significantly ameliorates patients general health.Dec 31, 2016

SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels.Dec 31, 2019

The clinical cases presented here reinforce the hypothesis that GcMAF could become part of anticancer immunotherapeutic regimens.Jul 31, 2013

This study demonstrates an association between low levels of serum 25[OH]D and increased orthopaedic infection.Dec 31, 2019

"Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants."Dec 10, 2012

1, 25-dihydroxyvitamin D3 downregulates cytotoxic effector response in pulmonary tuberculosis.Aug 31, 2018

1,25-dihydroxyvitamin D3 induces stable and reproducible therapeutic tolerogenic dendritic cells with specific epigenetic modifications.Dec 31, 2020

A Bifidobacteria mixture was able of significantly improving allergic rhinitis symptoms.Mar 06, 2017

A combined treatment of Lentinula edodes mycelia and immunotherapy might improve QOL and immunological function in cancer patients.Jun 30, 2016

A formula containing omega-3 fatty acids, arginine and RNA improves outcomes of surgery for esophageal cancer.Nov 01, 2007

A laughing Qigong program is a non-pharmacological and cost-effective means to help adolescents mitigate stresses in their everyday life.Nov 30, 2013

A maitake mushroom extract has beneficial immunomodulatory potential in patients with myelodysplastic syndromes.Oct 28, 2014

A polyphenol and antioxidant rich fruit and vegetable concentrate has therapeutic value in HIV patients due to enhanced proliferation, which could restore disturbances in T-cell homeostasis. Feb 01, 2004

A proprietary extract from the echinacea plant (Echinacea purpurea) enhances systemic immune response during a common cold.Aug 01, 2005

A vegetarian diet improves symptoms of atopic dermatitis in adults. Nov 01, 2001

Acupuncture could adjust the immune function of sepsis patients, improve their immunological indicators and prognoses.Jun 30, 2015

Acute phase proteins and vitamin D seasonal variation in end-stage renal disease patients.Mar 15, 2020

Addition of propolis to the standard care procedures resulted in clinical benefits for the hospitalized COVID-19 patients.May 31, 2021

Advanced effect of Moringa oleifera bioconversion by Rhizopus oligosporus on the treatment of atopic dermatitis.Dec 31, 2017

Aerobic exercise affects sleep, psychological wellbeing and immune system parameters among subjects with chronic primary insomnia.Nov 30, 2020

Aerobic training modulates T cell activation in elderly women with knee osteoarthritis.Dec 31, 2015

After 14 to 25 weekly administrations of GcMAF all patients had very low serum Nagalase levels equivalent to those of healthy control, indicating that these patients are tumor-free.Jun 30, 2008

AGE supplementation may enhance immune cell function and may be partly responsible for the reduced severity of colds and flu reported.Jan 31, 2016

Aged garlic extract may be beneficial in preventing the development of chronic diseases associated with low-grade inflammation.Dec 31, 2017

Andrographis paniculate might be used as a potential natural drug for treating COVID-19.Jan 31, 2023

Anthocyanin-rich apples may influence immune function compared to control apples.Mar 26, 2021

Antibody titers against EBV in MS patients rise after the onset of the disease and indicate that vitamin D3 supplementation could limit augmentation of these titers in MS patients.Feb 28, 2015

Antibody titers for all HPV strains were significantly higher among those with lower vitamin D levels and among younger participants.Jul 14, 2015

Arginine supplementation in total parenteral nutrition improves postoperative cellular immune function of patients with hepatocellular carcinoma after operationJul 01, 2007

Aromatherapy massage could significantly decrease stress and enhance immune function in pregnant women.Sep 30, 2017

Aromatherapy with light Thai massage can be beneficial for the immune systems of cancer patients who are undergoing chemotherapy.Dec 31, 2012

Arsenicum album appears to have great potential for ameliorating arsenic induced elevated ANA titer and other hematological toxicities.Feb 28, 2006

Association between serum vitamin D level and immune imbalance in advanced schistosomiasis patients with liver fibrosis.Feb 03, 2021

Astragalus has a positive immunomodulatory effect in patients with myasthenia gravia. Apr 01, 2009

Atopic asthmatics might benefit from zinc supplements.Apr 17, 2018

B infantis 35624 alleviates symptoms in IBS; this symptomatic response was associated with normalization of the ratio of an anti-inflammatory to a proinflammatory cytokine, suggesting an immune-modulating role for this organism, in this disorder.Mar 01, 2005

Bacillus clausii exerts immuno-modulatory activity in allergic subjects.Mar 31, 2005

Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise.Sep 01, 2013

Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition.Nov 16, 2020

Beneficial effects of Phyllanthus amarus leaves on hangover symptoms.Nov 30, 2019

Beta-glucan, but not vitamin D or placebo, results in significant improvements of natural killer cell numbers.Apr 04, 2020

Bifidobacterium alleviated Guillain-Barré syndrome by regulating Th cells.Jul 31, 2018

Bloodroot and echinacea offset exercise-associated effects of immune activity.Nov 01, 2009

Blueberries exert immunomodulatory effects and attenuate oxidative stress and inflammation in adults with metabolic syndrome.Nov 14, 2017

Broccoli sprout homogenates increases virus-induced peripheral blood NK cell granzyme B production.Dec 31, 2015

Camel milk had a regulatory effect on multiple parameters of inflammatory mediators, immunomodulators, antiapoptosis, and antioxidants.Oct 31, 2015

Cannabis could be potentially beneficial reduction in systemic inflammation and immune activation in the context of antiretroviral-treated HIV infection.Feb 16, 2018

Cellular immune response to acute exercise: Comparison of endurance and resistance exercise.Mar 26, 2020

Changes in transcript, metabolite and antibody reactivity during the early protective immune response in humans to Mycobacterium tuberculosis infection.Aug 14, 2019

Changing of fecal flora and clinical effect of L. salivarius LS01 in adults with atopic dermatitis.Sep 30, 2012

Children with measles studied in this New York City outbreak had lower vitamin A levels and were more likely to have a high fever for more than 7 days, be hospitalized, have lower measles antibodies, and increased morbidity. Feb 01, 1992

Citrus juice fermented with Lactobacillus plantarum YIT 0132 alleviates symptoms of perennial allergic rhinitisSep 15, 2016

Coix seed consumption affects the gut microbiota and the peripheral lymphocyte subset profiles of healthy male adults.Nov 14, 2021

Consumption of yoghurt fermented with L. bulgaricus OLL1073R-1 augmented natural killer cell activity and reduced the risk of catching the common cold in elderly individuals.Oct 01, 2010

Continual intake of a probiotic drink containing Lactobacillus brevis led to a reduction in the incidence of influenza, especially in subjects not inoculated with influenza vaccine.Nov 30, 2014

Immunomodulatory

View the Evidence:
1953 Abstracts with Immunomodulatory Research