Immunomodulatory

Name	AC	CK
Vitamin D	197	752
Probiotics	77	251
Curcumin	107	239
Vitamin C	79	200
Selenium	30	119
Lactobacillus plantarum	36	116
Echinacea	31	112
Ginsenosides	51	106
Flavonoids	46	104
Fermented Foods and Beverages	22	89
Nigella sativa (aka Black Seed)	29	81
Yoghurt	12	79
Beta-glucan	18	73
Maitake Mushroom	21	67
Polyphenols	21	66
Zinc	25	65
Fucoidan	20	63
Moringa oleifera	16	61
Garlic	22	59
Apigenin	22	53
Omega-3 Fatty Acids	14	52
Cannabidiol	26	47
Resveratrol	28	46
Hydrogen: Molecular	15	44
Peony	16	43
Whey	5	43
Fruit: All	6	42
NAC (N-acetyl-L-cysteine)	11	42
Lactobacillus rhamnosus	13	41
Reishi Mushroom	24	41
Spirulina	13	41
Bifidobacterium Infantis	8	40
EGCG (Epigallocatechin gallate)	27	40
Goji	15	40
Bee Propolis	9	39
Berberine	26	39
Gc protein-derived macrophage activating factor (GcMAF)	6	39
Lactobacillus rhamnosus GG	13	39
Chlorella (Algae)	12	38
Ginger	13	38
Astaxanthin	16	37
Chokeberry	11	37
Ginseng (Korean)	12	37
Thymoquinone	17	37
Lactobacillus paracasei	6	36
Shiitake Mushroom	13	36
Lactoferrin	26	34
Bifidobacterium Longum	10	33
Lactobacillus casei	13	33
Melatonin	24	33
Sophora Flavescens	13	33
Ashwagandha	14	32
Bee Venom	13	32
Vitamin E	19	32
Andrographis	9	30
Homeopathic Medicine: All	7	30
Vegetables: All	3	30
Bifidobacterium animalis	7	29
Kefir	7	29
Lactobacillus reuteri	11	29
Anthocyanins	8	28
Oligosaccharides	10	28
Palmitoylethanolamide	8	28
Quercetin	21	27
Shikonin	12	27
Paeoniflorin	18	26
Turmeric	11	26
Fiber	5	25
Rice Bran	6	25
Arginine	4	24
Astragalus	12	24
Bifidobacterium Bifidum	4	24
Cannabis	10	24
Royal Jelly	11	24
Astragaloside	16	23
Modified Arabinoxylan Rice Bran (MGN-3)	4	23
Vitamin A	13	23
Evening Primrose Oil	3	22
Garlic: Aged	3	22
Iodine	3	22
Lactobacillus helveticus	4	22
Naringenin	14	22
Riboflavin (Vitamin B-2)	4	22
Apple	3	21
Glutathione	3	21
Guduchi	10	21
Lactobacillus fermentum	7	21
Oyster Mushroom	3	21
Pantothenic Acid (Vitamin B-5)	3	21
Cordyceps Militaris	14	20
Ginkgo biloba	5	20
Olive Oil	2	20
Medicinal Mushrooms	16	19
Andrographolide	12	18
Black Tea	6	18
Chaga Mushroom (Inonotus obliquus)	10	18
Fig	6	18
Honey	13	18
Lactobacillus probiotics	6	18
Lion's Mane (Hericium Erinaceus)	12	18
Purslane	7	18
Sea buckthorn	6	18
Cannabinoids	8	17
Glycyrrhizin	7	17
Lactobacillus Acidophilus	5	17
Papaya: Fermented	3	17
Polyunsaturated Fatty Acids (PUFAs)	7	17
Adlay	5	16
Cucurbitacin B	6	16
Glutamine	4	16
Grape	6	16
Green Tea	10	16
Lactobacillus salivarius	5	16
Neem	6	16
Sulforaphane	9	16
Urolithin A	5	16
Blueberry	4	15
Fish Oil	4	15
Licorice	10	15
Prunella vulgaris	11	15
Puerarin	4	15
Tanshinone IIA	9	15
Carotenoids	4	14
Honeysuckle	10	14
Panax Notoginseng	4	14
Salvia miltiorrhiza	8	14
Silibinin	5	14
Bromelain	4	13
Delta-tetrahydrocannabinol (THC)	8	13
Lactobacillus Brevis	3	13
Mangiferin	9	13
Papaya	9	13
Persimmon	3	13
Prebiotics	9	13
Terminalia	4	13
Wheat Grass	2	13
White Button Mushroom	3	13
Bacillus Clausii	3	12
Coenzyme Q10	3	12
Dandelion	7	12
Elderberry	5	12
Genistein	8	12
Ginseng	10	12
Glycyrrhiza uralensis	2	12
Hemp Seed	2	12
Lactococcus lactis	8	12
Moxibustion	2	12
Noni	7	12
Seaweed: Brown	7	12
Testosterone	2	12
Theanine	3	12
Vitamin B-6	3	12
Black Pepper	6	11
Broccoli Sprouts	2	11
Celastrol	7	11
Copper	2	11
Hesperidin	7	11
Pectin	2	11
Psilocybin	2	11
Vitamin C: Intravenous	2	11
Alternanthera pungens	1	10
Arabinoxylans	1	10
Bifidobacterium Lactis	1	10
Bloodroot	1	10
Camel Milk	1	10
Carnitine	1	10
Guar gum	1	10
Homeopathic Arsenicum album	1	10
Human Cord Blood	1	10
Infection/Infectitious Agent Byproducts (Beneficial)	1	10
L-Carnitine	1	10
Lactobacilius bulgaricus	1	10
Lactobacillus casei: Shirota	1	10
Lithospermum erythrorhizon	1	10
Modified Rice Bran (MGN-3)	1	10
Oleic acid	1	10
Pantethine	1	10
Phyllanthus amarus	1	10
Poria cocos	8	10
Ribonucleic acid (RNA)	1	10
Saffron	8	10
Tongkat Ali	1	10
Zeolite	1	10
Agaricus Blazei	5	9
Aloe Vera	7	9
Baicalein	6	9
Bitter Melon	5	9
Emodin	7	9
Mistletoe	5	9
Onion	5	9
Phloretin	6	9
Black Raspberry	5	8
Cordyceps sinensis	5	8
Gallic Acid	4	8
Hydrogen Water	4	8
Lotus	5	8
Luteolin	7	8
Ursolic Acid	5	8
Zataria multiflora	5	8
Burdock	4	7
Cocoa	5	7
Holy Basil	4	7
Kaempferol	5	7
Lycopene	5	7
Milk: Fermented	4	7
Mushrooms: All	6	7
Myricetin	5	7
Oleuropein	4	7
Olive leaf extract	3	7
Oridonin	4	7
Piperine	6	7
Plantago	4	7
Pomegranate	5	7
Walnut	4	7
18β-Glycyrrhetinic Acid	3	6
Allicin	4	6
Arctigenin	4	6
Basil	3	6
Cinnamon	4	6
Geranium	2	6
Icariin	5	6
Lactobacillus delbrueckii Subsp	3	6
Lupeol	4	6
Parsley	2	6
St. Johns Wort	4	6
Sweet Potato: Purple	3	6
Vitamin E: alpha tocopherol	3	6
Asiatic Acid	3	5
Bamboo	3	5
Beta-Caryophyllene	3	5
Boron	3	5
Crocin	4	5
Daisy	1	5
Diosmetin	2	5
Fisetin	3	5
Frankincense	2	5
Gingerol	4	5
Ginseng (Siberian)	3	5
Nicotinamide	1	5
Paeonol	3	5
Parthenolide	3	5
Plantago asiatica	3	5
Plumbagin	3	5
Psychedelics:All	4	5
Rutin	3	5
Seaweed	4	5
Thiamine (B-1)	4	5
Woodfordia fruticosa	3	5
Zerumbone	4	5
Alpha-Lipoic Acid	3	4
Angelica	2	4
Artesunate	2	4
Asparagus	3	4
Bai Zhu	2	4
Beta Sitosterol	2	4
Black Currant	3	4
Boswellic Acid	2	4
Caffeic acid phenethyl ester	3	4
Carvacrol	2	4
Chrysin	3	4
Cinnamaldehyde	3	4
DHA (Docosahexaenoic Acid)	2	4
Daidzein	2	4
Dates	3	4
Gynostemma	3	4
Hawthorn	3	4
Honokiol	2	4
Indole-3-Carbinol	2	4
Mango	3	4
Manuka Honey	2	4
Mucuna pruriens (aka Velvet Beans)	2	4
Okra	2	4
Perilla	3	4
Phellinus Linteus	3	4
Phlorotannins	3	4
Raspberry	2	4
Rosemaric Acid	3	4
Rubia Cordifolia	2	4
Safflower	2	4
Sea Cucumber	2	4
Shitake Mushroom	3	4
Silver (nanoparticles)	3	4
Stigmasterol	2	4
Turkey Tail Mushroom	4	4
Verbascoside	3	4
Vitexins	2	4
Bael	2	3
Banana	2	3
Beta-Elemene	2	3
Bifidobacterium Breve	2	3
Bisdemethoxycurcumin	2	3
Blue Honeysuckle	2	3
Butyrate	2	3
Carnosol	2	3
Catechin	2	3
Celery Oil	1	3
Coconut Oil	2	3
Crocetin	3	3
Curcuminoids	1	3
D-Mannose	3	3
Diosgenin	3	3
EPA (Eicosapentaenoic Acid)	2	3
Eriodictyol	2	3
Eugenol	2	3
Gambogic Acid	3	3
Gastrodin	2	3
Hops	2	3
Jujube	2	3
Kanuka Honey	1	3
Ketone Bodies	2	3
Kiwifruit	2	3
Kombucha Tea	3	3
Magnesium	3	3
Magnolol	2	3
Nobiletin	2	3
Organosulfur Compounds	3	3
Piperlongumine	2	3
Prickly Pear Cactus	2	3
Propolis: Bee	2	3
Pterostilbene	3	3
Pumpkin	2	3
Red Marine Algae	1	3
Rose	3	3
Rosemary	3	3
Saccharomyces Boulardii	1	3
Sinomenine	2	3
Strawberry	2	3
Thyme	2	3
White Mulberry	2	3
Wogonin	2	3
6-Shogaol	1	2
Acacia catechu	1	2
Acai	1	2
Acetic Acid	1	2
Algae	1	2
Alpha Linolenic Acid	1	2
Amaranth	1	2
Amla Fruit	1	2
Amygdalin (laetrile)	1	2
Anandamide	1	2
Antrodia camphorata	2	2
Apples	1	2
Artemisinin	1	2
Artichoke	1	2
Babchi	1	2
Bacillus subtilis	1	2
Barberry	1	2
Bee Pollen	1	2
Beet	1	2
Betulinic acid	2	2
Biochanin A	1	2
Broccoli	2	2
Buckwheat	1	2
Bufalin	1	2
Cardamom	1	2
Carnosic Acid	2	2
Carrageenans	1	2
Cat's Claw	2	2
Chicoric Acid	1	2
Chinese Skullcap	1	2
Chlorogenic Acid	2	2
Citrus Pectin	1	2
Citrus Triterpenoids	1	2
Coconut	1	2
Codonopsis pilosula	1	2
Common bean	1	2
Coriolus versicolor	1	2
Coumestrol	1	2
Cranberry	1	2
Cucurbitacin E	1	2
Cumin	1	2
Diallyl sulfide	1	2
Diosmin	1	2
Elm tree	1	2
Endocannabinoids	1	2
Eucalyptus	1	2
FOS (Fructooligosaccharides)	1	2
Ferulic acid	1	2
Fruit Peel	1	2
Fucoxanthin	2	2
Galacto-oligosaccharides	1	2
Galactooligosaccharides	1	2
Ganoderic acid	2	2
Garcinia hanburyi	2	2
Garcinia kola	1	2
Garden Cress (Lepidium sativum)	2	2
Gardenia	1	2
Genipin	1	2
Geraniol	1	2
Germanium	1	2
Ginseng (American)	2	2
Goldenrod	1	2
Guarana	2	2
Gymnema Sylvestre	1	2
Horse Chestnut	1	2
Horsetail	1	2
Ice Man Fungus	1	2
Inulin	1	2
Iron	2	2
Isoliquiritigenin	1	2
Jambul	2	2
Kimchi	1	2
Lactobacillus sakei	1	2
Lemon	1	2
Ligustrazine	1	2
Liquiritigenin	1	2
Longan	1	2
Loquat	1	2
Loquat Seeds	1	2
Lupine	1	2
Lychee	1	2
Lysergic Acid Diethylamide (LSD)	2	2
Mangifera indica	1	2
Mangosteen	1	2
Melia azedarach	1	2
Motherwort	1	2
Mululuza	1	2
Mung Bean	1	2
Myrrh	2	2
Myrtenol	1	2
Nicotinamide Mononucleotide	1	2
Noni leaf extract	1	2
Oak	1	2
Oleanolic acid	1	2
Olive	1	2
Orchid	2	2
Orthosiphon	1	2
P-Coumaric Acid	1	2
Panaxadiol	1	2
Patchouli	1	2
Peanut	1	2
Pine Bark Extract	1	2
Pine Buds	1	2
Pine Cone	1	2
Pine Needle	1	2
Plantago lanceolata	1	2
Pomegranate Peel	2	2
Propionibacterium freudenreichii	1	2
Propolis: Brazillian	2	2
Punicic acid	1	2
Pycnogenol (Pine Bark)	1	2
Radish	1	2
Scutellaria barbata	1	2
Sea Salt	1	2
Sesame Seed Oil	1	2
Silymarin	2	2
Soup	1	2
Stilbenes	1	2
Streptococcus thermophilus	1	2
Suma (Pfaffia Paniculata)	1	2
Sumac	1	2
Tarragon	1	2
Thioproline	1	2
Thistle	1	2
Thymol	2	2
Thymus Extract	1	2
Triphala	2	2
Vaccenic acid	1	2
Vanillic Acid	1	2
Vinegar	1	2
Vinpocetine	1	2
Viruses: Beneficial	2	2
Vitamin B-12	2	2
Vitamin B-5 (Pantothenic Acid)	1	2
Xanthohumol	1	2
Xanthones	2	2
Yeast	1	2
beta-Carotene	2	2
neohesperidin	1	2
Amygdalin	1	1
Antioxidant formulas	1	1
Apricot	1	1
B-Carotene	1	1
Bacopa	1	1
Beans: All	1	1
Bifidobacterium	1	1
Bitter Orange	1	1
Blue-Green Algae	1	1
Butterfly Pea	1	1
Cabbage	1	1
Caffeic Acid	1	1
Capsaicin	1	1
Carpolobia lutea	1	1
Celery seed	1	1
Chia	1	1
Chili pepper	1	1
Chrysanthemum Indicum	1	1
Citrulline	1	1
Cod Liver Oil	1	1
Cruciferous Vegetables	1	1
Curry Leaves	1	1
Cycloastragenol	1	1
Dogwood	1	1
Dragon Fruit	1	1
Durian	1	1
Elecampane	1	1
Ellagic Acid	1	1
Enterococcus faecium	1	1
Epimedium	1	1
Essential Oils: Unspecified	1	1

[+]

Bioactive compounds from kefir and their potential benefits on health.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Thyroid. 2016 Nov 2. Epub 2016 Nov 2. PMID: 27702392

Article Published Date : Nov 01, 2016

Study Type : Meta Analysis, Review

Additional Links

Substances : Selenium

Diseases : Autoimmune Thyroiditis

Pharmacological Actions : Immunomodulatory

[+]

The effects of Tai chi and Qigong on immune responses.Jun 29, 2020

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Pubmed Data : J Pharmacol Pharmacother. 2012 Oct ;3(4):300-3. PMID: 23326099

Article Published Date : Oct 01, 2012

Study Type : Meta Analysis

Additional Links

Substances : Vitamin D

Diseases : Respiratory Tract Infections

Pharmacological Actions : Immunomodulatory

Additional Keywords : vaccine alternatives

Anti Therapeutic Actions : Vaccination: All

[+]

Vitamin D supplementation can be considered as a combination therapy in patients with pulmonary tuberculosis.Jun 27, 2018

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Pubmed Data : Hum Exp Toxicol. 2021 Dec ;40(12):2113-2122. Epub 2021 Jun 4. PMID: 34085585

Article Published Date : Nov 30, 2021

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Pubmed Data : Front Nutr. 2023 ;10:1152680. Epub 2023 Apr 17. PMID: 37139438

Article Published Date : Dec 31, 2022

Study Type : Human Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Pharmacological Actions : Immunomodulatory

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Hum Vaccin Immunother. 2015 Jul 15:0. Epub 2015 Jul 15. PMID: 26176493

Article Published Date : Jul 14, 2015

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Pubmed Data : Asian Pac J Cancer Prev. 2013 ;14(6):3903-7. PMID: 23886205

Article Published Date : Dec 31, 2012

Study Type : Human Study

Additional Links

Substances : Ginger

Diseases : Colorectal Cancer

Therapeutic Actions : Aromatherapy Massage

Pharmacological Actions : Immunomodulatory

[+]

Pubmed Data : Eur J Haematol. 2020 Mar 27. Epub 2020 Mar 27. PMID: 32221992

Article Published Date : Mar 26, 2020

Study Type : Human Study

Additional Links

Diseases : Inflammation

Therapeutic Actions : Exercise: Endurance, Exercise: Resistance Training

Pharmacological Actions : Immunomodulatory

[+]

Changes in transcript, metabolite and antibody reactivity during the early protective immune response in humans to Mycobacterium tuberculosis infection.Aug 14, 2019

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Pubmed Data : BMC Oral Health. 2023 Sep 19 ;23(1):678. Epub 2023 Sep 19. PMID: 37726676

Article Published Date : Sep 18, 2023

Study Type : Human Study

Additional Links

Substances : Purslane

Diseases : Oral Lichen Planus

Pharmacological Actions : Immunomodulatory

Additional Keywords : Significant Treatment Outcome

[+]

Consumption of yoghurt fermented with L. bulgaricus OLL1073R-1 augmented natural killer cell activity and reduced the risk of catching the common cold in elderly individuals.Oct 01, 2010

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Pubmed Data : Br J Nutr. 2010 Oct;104(7):998-1006. Epub 2010 May 21. PMID: 20487575

Article Published Date : Oct 01, 2010

Study Type : Human Study

Additional Links

Substances : Fermented Foods and Beverages, Lactobacilius bulgaricus, Yoghurt

Diseases : Common Cold, Low Immune Function: Natural Killer Cells

Pharmacological Actions : Immunomodulatory

[+]

Continual intake of a probiotic drink containing Lactobacillus brevis led to a reduction in the incidence of influenza, especially in subjects not inoculated with influenza vaccine.Nov 30, 2014

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Pubmed Data : J Cardiovasc Pharmacol Ther. 2025 ;30:10742484251351124. Epub 2025 Jul 6. PMID: 40619868

Article Published Date : Dec 31, 2024

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Myocardial Infarction

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Immunomodulatory, Interleukin-6 Downregulation

[+]

Curcumin mitigates systemic lupus erythematosus by suppressing double-negative T cells through cell apoptosis.Jul 31, 2025

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Pubmed Data : Cell Immunol. 2025 Aug ;414:104996. Epub 2025 Jun 16. PMID: 40532482

Article Published Date : Jul 31, 2025

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Anti-Apoptotic, Immunomodulatory

[+]

Curcumin was demonstrated to be effective as an adjuvant therapy for the treatment of psoriasis vulgaris and to significantly reduce serum levels of IL-22.Dec 31, 2014

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Pubmed Data : Viruses. 2023 Dec 15 ;15(12). Epub 2023 Dec 15. PMID: 38140675

Article Published Date : Dec 14, 2023

Study Type : Human Study

Additional Links

Substances : Vitamin D

Diseases : Coronavirus Disease (Covid-19), Lung Damage, Lung Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Dimethylglycine has mmunomodulating properties in humans.Nov 01, 2008

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Pubmed Data : Med Sci Sports Exerc. 2008 Nov;40(11):1863-72. PMID: 6163829

Article Published Date : Nov 01, 2008

Study Type : Human Study

Additional Links

Diseases : Immune Disorders: Low Immune Function

Pharmacological Actions : Immunomodulatory

[+]

Diospyros peregrina fruit preparation mediated immunomodulation of lymphocytes isolated from the blood of breast cancer patients.Dec 31, 2020

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Pubmed Data : Iran J Immunol. 2021 06 ;18(2):111-118. PMID: 34190692

Article Published Date : Dec 31, 2020

Study Type : Human Study

Additional Links

Substances : Persimmon

Diseases : Breast Cancer

Pharmacological Actions : Immunomodulatory

Additional Keywords : Gene Expression Regulation

[+]

Direct infant UV light exposure is associated with eczema and immune development.Dec 31, 2018

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Pubmed Data : J Allergy Clin Immunol. 2019 03 ;143(3):1012-1020.e2. Epub 2018 Oct 23. PMID: 30366577

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Pubmed Data : Benef Microbes. 2019 Oct 14 ;10(7):729-739. Epub 2019 Jul 24. PMID: 31965842

Article Published Date : Oct 13, 2019

Study Type : Human Study

Additional Links

Substances : Bifidobacterium Bifidum, Bifidobacterium Infantis, Lactobacillus helveticus, Probiotics

Pharmacological Actions : Immunomodulatory

[+]

Ginsan significantly enhanced natural killer (NK) cell cytotoxic activity by 40% after administration for 14 weeks.Dec 31, 2013

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Pubmed Data : J Transl Med. 2014 ;12:283. Epub 2014 Oct 9. PMID: 25297058

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Pubmed Data : J Clin Med. 2025 Feb 11 ;14(4). Epub 2025 Feb 11. PMID: 40004710

Article Published Date : Feb 10, 2025

Study Type : Human Study

Additional Links

Diseases : Coronavirus Disease (Covid-19)

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Cytokine Storm

[+]

Hemp seed and evening primrose oils with hot-nature diet have beneficial effects in improving the clinical score in multiple sclerosis patients.Sep 30, 2013

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Pubmed Data : Complement Ther Med. 2013 Oct ;21(5):473-80. Epub 2013 Jul 25. PMID: 24050582

Article Published Date : Sep 30, 2013

Study Type : Human Study

Additional Links

Substances : Evening Primrose Oil, Hemp Seed

Diseases : Inflammation, Multiple Sclerosis: Relapsing-Remitting

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Dietary Modification, Phytotherapy, Plant Extracts

[+]

High dose intravenous vitamin C for preventing the disease aggravation of moderate COVID-19 pneumonia.Dec 31, 2020

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Pubmed Data : J Pediatr Endocrinol Metab. 2020 May 26 ;33(5):613-621. PMID: 32352398

Article Published Date : May 25, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin D

Pharmacological Actions : Immunomodulatory

[+]

High-fiber dietary supplementation decreased the markers of bone erosion in rheumatoid arthritis patients.Oct 06, 2019

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Pubmed Data : Int J Environ Res Public Health. 2021 Jun 17 ;18(12). Epub 2021 Jun 17. PMID: 34204400

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Pubmed Data : Homeopathy. 2023 Mar 7. Epub 2023 Mar 7. PMID: 36882111

Article Published Date : Mar 06, 2023

Study Type : Human Study

Additional Links

Substances : Homeopathic Medicine: All

Diseases : Atopic Dermatitis

Pharmacological Actions : Immunomodulatory

[+]

Infants with total 25(OH)D <20 ng/mL had increased risk of intensive care and longer hospital stay.Jan 11, 2018

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Pubmed Data : J Pediatr. 2018 12 ;203:416-422.e1. Epub 2018 Sep 20. PMID: 30243543

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Pubmed Data : Adv Ther. 1998 Nov-Dec;15(6):362-71. PMID: 10351119

Article Published Date : Oct 31, 1998

Study Type : Human Study

Additional Links

Substances : Homeopathic Medicine: All

Diseases : Tonsillitis

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Plant Extracts

[+]

Korean red ginseng prolongs survival in HIV-1 patients, possibly by slowing the decrease in CD4+ T-cell count.Mar 31, 2017

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Pubmed Data : J Ginseng Res. 2017 Apr ;41(2):222-226. Epub 2017 Jan 6. PMID: 28413328

Article Published Date : Mar 31, 2017

Study Type : Human Study

Additional Links

Substances : Ginseng (Korean)

Diseases : HIV Infections

Pharmacological Actions : Immunomodulatory

Additional Keywords : Significant Treatment Outcome

[+]

Lacticaseibacillus rhamnosus GG in a chewable colonizes the nose and facilitates local immune benefits in allergic rhinoconjunctivitis patients.Oct 06, 2025

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Pubmed Data : J Interferon Cytokine Res. 2015 Nov ;35(11):875-87. Epub 2015 Jul 2. PMID: 26133750

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Mumps parotitis may lead to expression and immune recognition of a tumor-associated form of MUC1 and create effective immune surveillance of ovarian cancer cells that express this form of MUC1.Aug 01, 2010

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Additional Keywords : Natural Substances Versus Drugs

[+]

Probiotic administration could have beneficial effects on systemic humoral and mucosal immune responses.Dec 31, 2016

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Pubmed Data : J Strength Cond Res. 2017 Jan ;31(1):62-70. PMID: 27100317

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Lactobacillus helveticus

Pharmacological Actions : Immunomodulatory

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Probiotic administration in the elderly normalises the response to endotoxin, and modulates activation markers in blood phagocytes, and therefore may help reduce low-grade chronic inflammation.Jan 01, 2009

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Pubmed Data : Nutr Cancer. 2009;61(5):680-6. PMID: 19353762

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Substances : Fermented Foods and Beverages, Probiotics, Yoghurt

Diseases : Aging, Endotoxemia, Immune Disorders: Low Immune Function, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Immunomodulatory

[+]

Probiotic and peanut oral immunotherapy was effective in reducing the reactions to peanut skin prick test responses and peanut-specific IgE levels.Feb 28, 2015

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Pubmed Data : J Allergy Clin Immunol. 2015 Mar ;135(3):737-44.e8. Epub 2015 Jan 13. PMID: 25592987

Article Published Date : Feb 28, 2015

Study Type : Human Study

Additional Links

Substances : Lactobacillus rhamnosus , Probiotics

Diseases : Food Allergies

Pharmacological Actions : Immunomodulatory

Additional Keywords : Significant Treatment Outcome

[+]

Probiotic bacteria can provide specific benefit in HIV infected patients during antiretroviral treatment by improvement of the microbiota and reducing mucosal and systemic inflammation.Dec 31, 2014

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Pubmed Data : Mult Scler. 2011 Jun;17(6):743-54. Epub 2011 Mar 3. PMID: 21372112

Article Published Date : Jun 01, 2011

Study Type : Human Study

Additional Links

Substances : Probiotics

Diseases : Multiple Sclerosis, Multiple Sclerosis: Relapsing-Remitting

Pharmacological Actions : Immunomodulatory, Interleukin-10 upregulation, Interleukin-4 upregulation

[+]

Probiotics ingestion prevents HDAC11-induced DEC205+ dendritic cell dysfunction in night shift nurses.Nov 28, 2019

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Pubmed Data : Sci Rep. 2019 Nov 29 ;9(1):18002. Epub 2019 Nov 29. PMID: 31784669

Rice bran arabinoxylan compound and quality of life of cancer patients.Dec 31, 2023

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Pubmed Data : Zhong Xi Yi Jie He Za Zhi. 1991 Oct ;11(10):598-9, 580. PMID: 1806305

Article Published Date : Sep 30, 1991

Study Type : Human Study

Additional Links

Substances : Lithospermum erythrorhizon, Shikonin

Diseases : Lung Cancer, Squamous cell carcinoma

Pharmacological Actions : Antiproliferative , Immunomodulatory

[+]

Short meditation intervention in trained subjects may rapidly influence the epigenome at sites of potential relevance for immune function.Jan 31, 2020

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Pubmed Data : Brain Behav Immun. 2020 Feb ;84:36-44. Epub 2019 Nov 13. PMID: 31733290

Article Published Date : Jan 31, 2020

Study Type : Human Study

Additional Links

Therapeutic Actions : Meditation

Pharmacological Actions : Immunomodulatory

Additional Keywords : DNA Methylation, Epigenetic Modification

[+]

Short-term exposure to forest environment may have clinical and immunological effects in children with allergic diseasesJan 31, 2015

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Pubmed Data : Iran J Allergy Asthma Immunol. 2015 Feb ;14(1):28-36. PMID: 25530136

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Pubmed Data : Chiropr Osteopat. 2010 ;18:26. Epub 2010 Sep 8. PMID: 20825650

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Immune Disorders: Low Immune Function

Therapeutic Actions : Chiropractic treatment

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Immunoglobulin G up-regulation, Immunomodulatory: Immunoglobulin M Up-Regulation, Interleukin-2 upregulation

[+]

Substituting EVOO for oils used in a typical American diet may have both cardio-metabolic and immunologic health benefits as indicated by reduced systolic blood pressure.Dec 31, 2014

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Pubmed Data : Aliment Pharmacol Ther. 2020 Jan ;51(1):110-120. Epub 2019 Dec 3. PMID: 31797399

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Bifidobacterium animalis

Diseases : Colic

Pharmacological Actions : Gastrointestinal Agents, Immunomodulatory

[+]

Supplementation with L-theanine seems to exert a beneficial effect on a disrupted Th1/Th2 balance in elite athletes.Feb 14, 2019

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Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2023 ;69(5):326-339. PMID: 37940573

Article Published Date : Dec 31, 2022

Study Type : Human Study

Additional Links

Substances : Black Tea

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

[+]

The effects of nanocurcumin on immune-related factors in the ankylosing spondylitis patients.Mar 18, 2025

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Pubmed Data : Mol Biol Rep. 2025 Mar 19 ;52(1):324. Epub 2025 Mar 19. PMID: 40106064

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health. 2020 Nov 23 ;19(1):118. Epub 2020 Nov 23. PMID: 33228714

Article Published Date : Nov 22, 2020

Study Type : Human Study

Additional Links

Diseases : Aging, Electromagnetic Radiation Mitigation, Inflammation, Oxidative Stress

Pharmacological Actions : Immunomodulatory

Anti Therapeutic Actions : Electromagnetic Field Harms

Adverse Pharmacological Actions : Immunoreactive

[+]

The use of Alternanthera pungens herb tea by HIV-infected patients may lead to significant increase T lymphocytes and decrease in biomarkers of oxidative stress, and might help in the prevention of the opportunist diseasesSep 01, 2009

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Pubmed Data : Ann Biol Clin (Paris). 2009 Sep-Oct;67(5):563-8. PMID: 19789129

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : Alternanthera pungens

Diseases : HIV Infections

Pharmacological Actions : Antioxidants, Immunomodulatory

[+]

The use of palmitoylethanolamide in the treatment of long COVID.Jul 13, 2022

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Pubmed Data : Med Sci (Basel). 2022 Jul 14 ;10(3). Epub 2022 Jul 14. PMID: 35893119

Article Published Date : Jul 13, 2022

Study Type : Human Study

Additional Links

Substances : Palmitoylethanolamide

Diseases : Coronavirus Disease (Covid-19), Covid: Long

Pharmacological Actions : Immunomodulatory

Additional Keywords : Cytokine Storm, Long Covid

[+]

Therapeutic effect of vitamin D in Hashimoto's thyroiditis.Dec 31, 2022

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These results showed improvements with 3-month royal jelly treatment in regard to the clinical severity score and laboratory markers for the disease.Dec 31, 2015

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Pubmed Data : Food Nutr Res. 2016 ;60:32963. Epub 2016 Nov 24. PMID: 27887663

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Royal Jelly

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Immunomodulatory

[+]

These results suggest that acute exercise could be used to offset mucosal associated invariant T cell deficiencies observed with certain pathologies.Aug 31, 2017

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Pubmed Data : Eur J Appl Physiol. 2017 Sep 1. Epub 2017 Sep 1. PMID: 28864849

Article Published Date : Aug 31, 2017

Study Type : Human Study

Additional Links

Therapeutic Actions : Exercise: Aerobic

Pharmacological Actions : Immunomodulatory

[+]

Third-trimester high-dose vitD3 supplementation in healthy pregnant women had balanced effects on biomarkers of cord blood Th1 and Th2 responses.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutr J. 2016 ;15(1):75. Epub 2016 Aug 9. PMID: 27506771

Article Published Date : Dec 31, 2015

Study Type : Human Study

Additional Links

Substances : Vitamin D

Pharmacological Actions : Immunomodulatory

Additional Keywords : Gene Expression Regulation

[+]

This pilot study found low serum levels of vitamin C and vitamin D in most of our critically ill COVID-19 ICU patients.Nov 30, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Med Drug Discov. 2020 Dec ;8:100064. Epub 2020 Sep 18. PMID: 32964205

Article Published Date : Nov 30, 2020

Study Type : Human Study

Additional Links

Substances : Vitamin C, Vitamin D

Diseases : Coronavirus Infection, Vitamin C Deficiency, Vitamin D Deficiency

Pharmacological Actions : Immunomodulatory

Additional Keywords : Risk Factors

[+]

This pilot study showed the beneficial effect of sea buckthorn as add on treatment for idiopathic nephrotic syndrome.May 31, 2013

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Pubmed Data : J Assoc Physicians India. 2013 Jun ;61(6):397-9. PMID: 24640205

Article Published Date : May 31, 2013

Study Type : Human Study

Additional Links

Substances : Sea buckthorn

Diseases : Nephrotic Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory

Additional Keywords : Plant Extracts

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View the Evidence: 2519 Abstracts with Immunomodulatory Research

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Acupuncture can be a possible treatment for respiratory diseases through its modulation of various cytokines, leading to reduced inflammation.Dec 31, 2021

Add-on effects of total glucosides of paeony on conventional therapies for psoriasis.Dec 31, 2024

Moringa oleifera supplementation significantly improves immune function and nutritional status in individuals living with HIV.Dec 31, 2024

Rhinophototherapy showed to be an effective treatment for reducing the nasal symptom scores triggered by allergic rhinitis.Dec 31, 2020

The effect of ginsenoside Rg3 combined with chemotherapy on immune function in non-small cell lung cancer.Apr 06, 2023

The effects of apigenin administration on the inhibition of inflammatory responses and oxidative stress in the lung injury models.Jun 03, 2022

Bioactive compounds from kefir and their potential benefits on health.Dec 31, 2020

Efficacy of high-dose vitamin D supplementation as an adjuvant treatment on pneumonia.Mar 31, 2021

Evidence indicates that echinacea potently lowers the risk of recurrent respiratory infections and complications.Feb 28, 2015

Garlic supplements may be considered as a treatment option for hypertension, slightly elevated cholesterol, and stimulation of immunity.Jan 31, 2016

Ginsenoside Rg3 for chemotherapy-induced myelosuppression.Dec 31, 2019

Horticultural therapy for general health in the older adults.Dec 31, 2021

Meta-analysis on effect of Grifola frondosa polysaccharide in regulating in vivo immunoregulatory function.Nov 30, 2019

Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination.Dec 31, 2013

Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis.Nov 01, 2016

The effects of Tai chi and Qigong on immune responses.Jun 29, 2020

The favorable effect of probiotic use in the prevention of atopic dermatitis is similar regardless of the time of probiotic use (pregnancy or early life) or the subject(s) receiving probiotics (mother, child, or both).Mar 21, 2012

The probable protective effect of photobiomodulation on the inflammation of the airway and lung in COVID-19 treatment.Dec 31, 2021

Vitamin D decreases the events related to respiratory tract infections.Oct 01, 2012

Vitamin D supplementation can be considered as a combination therapy in patients with pulmonary tuberculosis.Jun 27, 2018

Whey protein supplementation raises CD4 cell counts in HIV-positive subjects.Nov 01, 2008

Zinc supplementation boosts the stress response in the elderly.May 01, 2008

Assessing the potential value and mechanism of Ginkgo biloba L. On coal-fired arsenic-induced skin damage.Nov 30, 2021

Ex vivo soft-laser treatment inhibits the synovial expression of vimentin and α-enolase, potential autoantigens in rheumatoid arthritis.Apr 30, 2011

Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans.Sep 21, 2023

Thymoquinone, a novel multi-strike inhibitor of pro-tumorigenic breast cancer markers.Sep 18, 2023

A single dose of cholecalcipherol (300,000 IU) combined with standard treatment significantly ameliorates patients general health.Dec 31, 2016

SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels.Dec 31, 2019

The clinical cases presented here reinforce the hypothesis that GcMAF could become part of anticancer immunotherapeutic regimens.Jul 31, 2013

This study demonstrates an association between low levels of serum 25[OH]D and increased orthopaedic infection.Dec 31, 2019

"Chlorella intake attenuates reduced salivary SIgA secretion in kendo training camp participants."Dec 10, 2012

1, 25-dihydroxyvitamin D3 downregulates cytotoxic effector response in pulmonary tuberculosis.Aug 31, 2018

1,25-dihydroxyvitamin D3 induces stable and reproducible therapeutic tolerogenic dendritic cells with specific epigenetic modifications.Dec 31, 2020

1,25-dihydroxyvitamin D3 provides benefits in vitiligo.Nov 05, 2023

A Bifidobacteria mixture was able of significantly improving allergic rhinitis symptoms.Mar 06, 2017

A combined treatment of Lentinula edodes mycelia and immunotherapy might improve QOL and immunological function in cancer patients.Jun 30, 2016

A formula containing omega-3 fatty acids, arginine and RNA improves outcomes of surgery for esophageal cancer.Nov 01, 2007

A laughing Qigong program is a non-pharmacological and cost-effective means to help adolescents mitigate stresses in their everyday life.Nov 30, 2013

A maitake mushroom extract has beneficial immunomodulatory potential in patients with myelodysplastic syndromes.Oct 28, 2014

A phase I/II trial of a polysaccharide extract from Maitake mushroom in breast cancer patients.Aug 31, 2009

A polyphenol and antioxidant rich fruit and vegetable concentrate has therapeutic value in HIV patients due to enhanced proliferation, which could restore disturbances in T-cell homeostasis. Feb 01, 2004

A pro-oxidant combination of resveratrol and copper down-regulates hallmarks of cancer and immune checkpoints in patients with advanced oral cancer.Dec 31, 2021

A proprietary black cumin oil extract modulates stress-sleep-immunity axis safely.Dec 31, 2022

A proprietary extract from the echinacea plant (Echinacea purpurea) enhances systemic immune response during a common cold.Aug 01, 2005

A prospective study to evaluate the possible role of cholecalciferol supplementation on autoimmunity in Hashimoto's thyroiditis.Dec 31, 2022

A red-fleshed apple rich in anthocyanins improves endothelial function, reduces inflammation, and modulates the immune system in hypercholesterolemic subjects.Jun 03, 2024

A standardized combination of Terminalia chebula and Withania somnifera extracts enhances immune function in adults.Dec 31, 2023

A study on immune improvement effects of ethanolic extract of Echinacea purpurea.May 13, 2024

A study on the clinical effect and immunological mechanism in the treatment of Hashimoto's thyroiditis by moxibustion.Feb 28, 1993

A vegetarian diet improves symptoms of atopic dermatitis in adults. Nov 01, 2001

Acupuncture could adjust the immune function of sepsis patients, improve their immunological indicators and prognoses.Jun 30, 2015

Acupuncture improves immunity and fatigue after chemotherapy in breast cancer patients.Aug 04, 2023

Acute natural killer cells response to a continuous moderate intensity and a work-matched high intensity interval exercise session in metastatic cancer patients.Sep 30, 2024

Acute phase proteins and vitamin D seasonal variation in end-stage renal disease patients.Mar 15, 2020

Adding L-carnitine and selenium to methimazole in Graves' disease.Aug 19, 2025

Addition of propolis to the standard care procedures resulted in clinical benefits for the hospitalized COVID-19 patients.May 31, 2021

Advanced effect of Moringa oleifera bioconversion by Rhizopus oligosporus on the treatment of atopic dermatitis.Dec 31, 2017

Aerobic exercise affects sleep, psychological wellbeing and immune system parameters among subjects with chronic primary insomnia.Nov 30, 2020

Aerobic training modulates T cell activation in elderly women with knee osteoarthritis.Dec 31, 2015

After 14 to 25 weekly administrations of GcMAF all patients had very low serum Nagalase levels equivalent to those of healthy control, indicating that these patients are tumor-free.Jun 30, 2008

AGE supplementation may enhance immune cell function and may be partly responsible for the reduced severity of colds and flu reported.Jan 31, 2016

Aged garlic extract may be beneficial in preventing the development of chronic diseases associated with low-grade inflammation.Dec 31, 2017

Andrographis paniculate might be used as a potential natural drug for treating COVID-19.Jan 31, 2023

Anthocyanin-rich apples may influence immune function compared to control apples.Mar 26, 2021

Antibody titers against EBV in MS patients rise after the onset of the disease and indicate that vitamin D3 supplementation could limit augmentation of these titers in MS patients.Feb 28, 2015

Antibody titers for all HPV strains were significantly higher among those with lower vitamin D levels and among younger participants.Jul 14, 2015

Arginine supplementation in total parenteral nutrition improves postoperative cellular immune function of patients with hepatocellular carcinoma after operationJul 01, 2007

Aromatherapy massage could significantly decrease stress and enhance immune function in pregnant women.Sep 30, 2017

Aromatherapy with light Thai massage can be beneficial for the immune systems of cancer patients who are undergoing chemotherapy.Dec 31, 2012

Arsenicum album appears to have great potential for ameliorating arsenic induced elevated ANA titer and other hematological toxicities.Feb 28, 2006

Association between serum vitamin D level and immune imbalance in advanced schistosomiasis patients with liver fibrosis.Feb 03, 2021

Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins.Dec 31, 2022

Immunomodulatory

View the Evidence:
2519 Abstracts with Immunomodulatory Research