Immunomodulatory: Th17 downregulation

Name	AC	CK
Zataria multiflora	3	13
Lactobacillus plantarum	2	12
Curcumin	2	11
Ginger	1	10
Omega-3 Fatty Acids	1	10
Silibinin	1	10
Resveratrol	4	7
Sulforaphane	3	7
Vitamin D	4	7
Berberine	3	6
EGCG (Epigallocatechin gallate)	3	6
Apigenin	1	5
Arctigenin	3	5
Fisetin	1	5
Astragalus	2	4
Burdock	2	4
Ginseng (Korean)	2	4
Mangosteen	2	4
Paeoniflorin	2	4
Cannabidiol	2	3
Flavonoids	2	3
Ginsenosides	2	3
Honeysuckle	2	3
Parthenolide	2	3
Peony	2	3
Acetic Acid	1	2
Agaricus Blazei	1	2
Astragaloside	2	2
Beta-Elemene	1	2
Black Pepper	1	2
Butyrate	1	2
Cannabis	1	2
Cinnamon	1	2
Coenzyme Q10	1	2
Cucurbitacin E	1	2
DHA (Docosahexaenoic Acid)	1	2
Delphinidin	1	2
Delta-tetrahydrocannabinol (THC)	1	2
Dong Quai	1	2
Evening Primrose Oil	1	2
Flaxseed	1	2
Gallic Acid	1	2
Hemp Seed	1	2
Honokiol	1	2
Hydrogen Water	1	2
Indole-3-Carbinol	1	2
Kudzu	1	2
Lactobacillus casei	1	2
Lactobacillus reuteri	1	2
Lactobacillus rhamnosus GG	1	2
Licorice	1	2
Mangiferin	1	2
Okra	1	2
Probiotics	2	2
Prunella vulgaris	1	2
Tanshinone IIA	1	2
Vinegar	1	2
Betulinic acid	1	1
Carnosol	1	1
Eriodictyol	1	1
Maitake Mushroom	1	1
Melatonin	1	1
Panax Notoginseng	1	1
Piperlongumine	1	1
Punicalagin	1	1
Red Wine Extract	1	1
Scopoletin	1	1
Tangeretin	1	1
Thymol	1	1
Urolithin A	1	1

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Pubmed Data : Am J Rhinol Allergy. 2022 May 18:19458924221098847. Epub 2022 May 18. PMID: 35585694

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Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation, Interferon Gamma Reducer

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Lactobacillus rhammosus GG might be an additional or supplementary therapy for allergic airway diseases.Mar 22, 2019

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Pubmed Data : PLoS One. 2015 ;10(1):e0116566. Epub 2015 Jan 8. PMID: 25569428

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Pubmed Data : Inflammopharmacology. 2019 Jul 15. Epub 2019 Jul 15. PMID: 31309485

Article Published Date : Jul 14, 2019

Study Type : Insect Study

Additional Links

Substances : Paeoniflorin

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Mol Nutr Food Res. 2020 01 ;64(1):e1900633. Epub 2019 Dec 11. PMID: 31730734

Article Published Date : Dec 31, 2019

Study Type : Animal Study

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Substances : Resveratrol

Diseases : Colitis

Pharmacological Actions : Immunomodulatory: Th17 downregulation, MicroRNA modulator

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SIRT3 activator honokiol inhibits Th17 cell differentiation and alleviates colitis.Jun 18, 2023

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The significance of Agaricus blazei as an immunomodulator of the level of IL-17 in Balb/C mice with atherosclerosis.Dec 31, 2019

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Pubmed Data : Cent Eur J Immunol. 2020 ;45(1):1-8. PMID: 32425674

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Agaricus Blazei

Diseases : Atherosclerosis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation

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These obtained results suggest that P. nigrum fruit extract has the promising strategy for immunotherapy in allergic rhinitis disease.Dec 31, 2018

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Pubmed Data : J Neuroimmunol. 2015 Jul 15 ;284:67-73. Epub 2015 May 12. PMID: 26025060

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HS-23, a Lonicera japonica extract, reverses sepsis-induced immunosuppression by inhibiting lymphocyte apoptosis.Aug 01, 2015

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Pubmed Data : J Ethnopharmacol. 2015 Aug 2 ;171:231-9. Epub 2015 Jun 9. PMID: 26068428

Article Published Date : Aug 01, 2015

Study Type : In Vitro Study

Additional Links

Substances : Honeysuckle

Diseases : Sepsis

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Immunomodulatory, Immunomodulatory: Th17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

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Tangeretin attenuates lipopolysaccharide-induced acute lung injury.Oct 28, 2019

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Pubmed Data : Microb Pathog. 2019 Oct 29:103826. Epub 2019 Oct 29. PMID: 31676364

Article Published Date : Oct 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Tangeretin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Inflammation

Pharmacological Actions : Immunomodulatory: Th17 downregulation, Interleukin-22 Downregulation

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Th17 cells as potential probiotic therapeutic targets in Inflammatory bowel diseases.Aug 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : EBioMedicine. 2021 Feb ;64:103227. Epub 2021 Jan 30. PMID: 33530002

Article Published Date : Jan 31, 2021

Study Type : In Vitro Study

Additional Links

Substances : Urolithin A

Diseases : Encephalomyelitis

Pharmacological Actions : Immunomodulatory, Immunomodulatory: Th17 downregulation

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Z. multiflora showed anti-inflammatory, antioxidant, and immunomodulatory effects.Jan 31, 2018

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Pubmed Data : Fundam Clin Pharmacol. 2018 Feb ;32(1):26-50. PMID: 29125648

Article Published Date : Jan 31, 2018

Study Type : Review

Additional Links

Substances : Zataria multiflora

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-4 downregulation

Additional Keywords : Phytotherapy, Plant Extracts

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View the Evidence: 100 Abstracts with Immunomodulatory: Th17 downregulation Research

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Ginger may be an effective adjuvant therapy for patients with relapsing-remitting MS.Apr 23, 2023

Immunomodulatory effects of nanocurcumin on Th17 cell responses in mild and severe COVID-19 patients.Dec 27, 2020

Lactobacillus plantarum IS-10506 supplementation reduced SCORAD in children with atopic dermatitis.Oct 12, 2017

Omega 3 supplementation can regulate inflammatory states in gas station workers.Mar 12, 2020

Oral administration of Zataria multiflora extract decreases IL-17 expression in perennial allergic rhinitis.Mar 31, 2018

Significant immunomodulatory and hepatoprotective impacts of Silymarin in MS patients.Apr 28, 2021

Modulation of Th17 proliferation and IL-17A gene expression by acetylated form of apigenin in patients with multiple sclerosis.Feb 25, 2020

These results suggest that fisetin has a great potential to be developed as an effective and inexpensive agent for the treatment of psoriasis.Sep 14, 2019

Sulforaphane effectively inhibits HBV by altering Treg/Th17 immune balance and the MIF-macrophages polarizing axis in vitro and in vivo.Feb 29, 2024

1,25(OH)2 D3 inhibited Th17 cells differentiation via regulating the NF-κB activity and expression of IL-17.Sep 30, 2018

Amelioration of experimental autoimmune encephalomyelitis by β-elemene treatment is associated with Th17 and Treg cell balance.Apr 30, 2011

Angelica sinensis polysaccharide prevents mitochondrial apoptosis by regulating the Treg/Th17 ratio in aplastic anemia.Jun 21, 2020

Anti-allergic rhinitis activity of α-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling.Jul 26, 2020

Arctigenin ameliorates colitis through down-regulating the differentiation of Th1 and Th17 cells via mTORC1 pathway. Aug 14, 2015

Arctigenin may have anti-inflammatory and immunosuppressive properties via inhibiting Th17 cells.Oct 05, 2015

Astilbin ameliorates experimental autoimmune myasthenia gravis.Jan 14, 2016

Astragalus polysaccharide exerts an effective therapeutic effect against experimental colitis by recovering the functional status of Treg cells.Mar 20, 2016

Astragalus polysaccharide relieves inflammatory responses in guinea pigs with allergic rhinitis.May 17, 2022

Autism is associated with dysregulation of transcription factor signalling that can be corrected by resveratrol treatment in mice. Aug 29, 2016

Berberine has anti-inflammatory effects on H. pylori-induced chronic gastritis.Jan 17, 2018

Berberine prevents ulcerative colitis by modifying gut microbiota and regulating the balance of Treg/Th17.Dec 31, 2017

Cucurbitacin E ameliorates acute graft-versus-host disease.Sep 17, 2018

Delphinidin diminishes in vitro interferon-γ and interleukin-17 producing cells in patients with psoriatic disease.Nov 24, 2021

Dietary indole-3-carbinol alleviated spleen enlargement, enhanced IgG response in C3H/HeN mice infected with Citrobacter rodentium.Oct 14, 2020

Docosahexaenoic acid Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis suppresses experimental autoimmune encephalomyelitis.Sep 18, 2010

EGCG decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice.Mar 07, 2016

EGCG has an antiarthritic effect by regulating the oxidative-antioxidant balance and cytokine levels.Nov 18, 2019

Evening primrose/hemp seed oil was able to reduce the severity of autoimmune encephalomyelitis and inhibited the development of the disease.Apr 15, 2020

Flos Abelmoschus manihot extract attenuates DSS-induced colitis by regulating gut microbiota and Th17/Treg balance.Aug 31, 2019

Gallic acid may be used as a therapeutic agent for allergic rhinitis.Mar 14, 2019

Green tea catechins alleviate autoimmune symptoms and visual impairment in a murine model for human chronic intraocular inflammation.Jan 18, 2019

Hydrogen rich water may have great potential in the treatment of Multiple sclerosis.May 14, 2016

Immunomodulatory effects of licochalcone A on experimental autoimmune encephalomyelitis.May 31, 2014

Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis.Feb 02, 2021

Isogarcinol has the potential to be an effective therapeutic agent of low toxicity for treating MS and other autoimmune diseases.Nov 29, 2016

Isogarcinol is a promising immunosuppressive agent for treating psoriasis.Jan 31, 2017

Ketogenic diet suppresses colorectal cancer through the gut microbiome long chain fatty acid stearate.Feb 19, 2025

Ketogenic diets alter the gut microbiome resulting in decreased intestinal Th17 cells. May 13, 2020

Korean red ginseng extract alleviated neurological impairment of myelin oligodendrocyte glycoprotein induced mouse model of chronic experimental autoimmune encephalomyelitis.Apr 06, 2015

Lactobacillus casei HY2782 and Pueraria lobata root extract complex ameliorates particulate matter-induced airway inflammation.Jun 29, 2022

Lactobacillus plantarum strains attenuated DSS-induced colitis.Apr 11, 2022

Lactobacillus reuteri reduces the severity of experimental autoimmune encephalomyelitis.Dec 31, 2018

Lactobacillus rhammosus GG might be an additional or supplementary therapy for allergic airway diseases.Mar 22, 2019

Mangiferin may ameliorate colitis by the restoration of disturbed Th17/Treg cells and inhibition of macrophage activation.Apr 30, 2016

NMN supplementation mitigated PM-induced lung injury by regulating immune functions and improving lipid metabolism in male mice.Jun 30, 2023

Oral administration of cinnamon powder may be beneficial in MS patients and that no other existing anti-MS therapies could be so economical and trouble free as this approach.Dec 31, 2014

Oral berberine exerted anti-arthritic effect through inhibiting Th17 cell response.Jun 20, 2017

Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated TH17/Treg balanceMay 28, 2020

Paeoniflorin inhibits Th1 and Th17 cells in gut-associated lymphoid tissues to produce anti-arthritis activities.Jul 14, 2019

Parthenolide suppresses T helper 17 and alleviates experimental autoimmune encephalomyelitis.Dec 31, 2021

Physical exercise attenuates experimental autoimmune encephalomyelitis.Dec 31, 2016

Prophylactic effects of Lonicera japonica extract on dextran sulphate sodium-induced colitis.Jan 27, 2013

Prunella vulgaris can improve the pregnancy outcomes of experimental autoimmune thyroiditis.Dec 23, 2021

Red ginseng extracts can ameliorate arthritis in mice with CIA by targeting pathogenic Th17 and osteoclast differentiation, suggesting a novel therapy for treatment of RA.Dec 31, 2013

Resveratrol modulates the gut microbiota to prevent murine colitis development.Mar 20, 2019

Resveratrol-mediated attenuation of colitis may be regulated by miR-31 through induction of Tregs and miR-31 may serve as a therapeutic target for human colitis.Dec 31, 2019

SIRT3 activator honokiol inhibits Th17 cell differentiation and alleviates colitis.Jun 18, 2023

Sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signalling and rectification of oxidant-antioxidant imbalance.Feb 18, 2019

Sulforaphane treatment reverses corticosteroid resistance in a mixed granulocytic mouse model of asthma.Jul 14, 2019

Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats.Jul 31, 2016

THC treatment during Delayed-type hypersensitivity response can simultaneously inhibit Th1/Th17 activation via regulation of microRNA expression.Mar 31, 2016

The consumption of phenolic and protein compounds extracted from flaxseeds has a protective effect on TNBS-induced colitis.Jun 21, 2018

The effect of Zataria multiflora on Th1/Th2 and Th17/T regulatory in a mouse model of allergic asthma.Dec 31, 2016

The significance of Agaricus blazei as an immunomodulator of the level of IL-17 in Balb/C mice with atherosclerosis.Dec 31, 2019

These obtained results suggest that P. nigrum fruit extract has the promising strategy for immunotherapy in allergic rhinitis disease.Dec 31, 2018

These results provide insights into butyrate as a potential therapeutic for the treatment of inflammatory bowel disease.Mar 26, 2019

These results suggest that vinegar supplementation might provide a new dietary strategy for the prevention of ulcerative colitis.Feb 09, 2016

These results support the use of CoQ10 as a potential targeted therapy for the treatment of colitis.Aug 31, 2017

This data suggests that CBD exerts its immunoregulatory effects via induction of CD4(+)CD25(-)CD69(+)LAG3(+) cells.Dec 31, 2014

Total glucosides of peony could be a potential therapeutic agent for multiple sclerosis.Jul 14, 2015

Vitamin D down-regulates the expression of inflammatory cytokines, chemokines and chemokine receptors in experimental autoimmune encephalomyelitis.Feb 14, 2018

Vitamin D has an effect on airway inflammation and Th17/Treg balance in asthmatic mice.Aug 29, 2021

Immunomodulatory: Th17 downregulation

View the Evidence:
100 Abstracts with Immunomodulatory: Th17 downregulation Research