Insulin-Like Growth Factor Inhibition/Downregulation

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21 Substances Researched for Insulin-Like Growth Factor Inhibition/Downregulation
NameACCKFocus
Milk Thistle212Locked
Silibinin212Locked
Anthocyanins110Locked
Black Currant110Locked
Caffeic Acid110Locked
Caffeine110Locked
Carnitine110Locked
Melatonin110Locked
Resveratrol110Locked
Silymarin110Locked
Soy Protein 110Locked
phytoestrogens110Locked
Genistein23Locked
Isoflavones23Locked
Beans: All 12Locked
CLA (Conjugated Linoleic Acid)22Locked
Curcumin22Locked
Daidzein12Locked
Grape Seed Extract12Locked
Inositol Hexaphosphate12Locked
Apigenin11Locked

View the Evidence:
19 Abstracts with Insulin-Like Growth Factor Inhibition/Downregulation Research

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Blackcurrant anthocyanins has the potential to be developed to treat neurological conditions with IGF-1 deficiency.Jun 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Jun 2 ;10(6). Epub 2018 Jun 2. PMID: 29865234
Article Published Date : Jun 01, 2018
Study Type : Human Study
Additional Links
Substances : Anthocyanins, Black Currant
Diseases : Parkinson's Disease
Pharmacological Actions : Insulin-Like Growth Factor Inhibition/Downregulation, Neuroprotective Agents
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Exercise-induced Human Growth Hormone secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects.Jul 01, 1999

Pubmed Data : Eur J Endocrinol. 1999 Jul;141(1):22-6. PMID: 10407218
Article Published Date : Jul 01, 1999
Study Type : Human Study
Additional Links
Substances : Melatonin
Diseases : Athletic Performance, Human Growth Hormone: Enhancement
Pharmacological Actions : Insulin-Like Growth Factor Inhibition/Downregulation
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L-carnitine supplementation reduces exercise-induced tissue damage and recovery time. Aug 01, 2003

Pubmed Data : J Strength Cond Res. 2003 Aug;17(3):455-62. PMID: 12930169
Article Published Date : Aug 01, 2003
Study Type : Human Study
Additional Links
Substances : Carnitine
Diseases : Athletic Performance: Recovery
Pharmacological Actions : Insulin-Like Growth Factor Inhibition/Downregulation
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Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption.Feb 16, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Clin Cancer Res. 2015 Feb 17. Epub 2015 Feb 17. PMID: 25691730
Article Published Date : Feb 16, 2015
Study Type : Human Study
Additional Links
Substances : Caffeic Acid, Caffeine
Diseases : Breast Cancer, Breast Cancer: Estrogen
Pharmacological Actions : Anti-Tumor, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, Estrogen Receptor Modulators, Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords : Dose Response, Risk Reduction
Problem Substances : Tamoxifen
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Oral silibinin, an IGF-1 binder, may result in lowered IGF-1 levels in liver and colorectal cancer patients as indicated by its accumulation in blood and tissue samples. May 01, 2006

Pubmed Data : Clin Cancer Res. 2006 May 1;12(9):2944-50. PMID: 16675592
Article Published Date : May 01, 2006
Study Type : Human Study
Additional Links
Substances : Milk Thistle, Silibinin, Silymarin
Diseases : Colorectal Cancer, Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Insulin-Like Growth Factor Inhibition/Downregulation
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Resveratrol reduces insulin-like growth factor levels in healthy volunteers, indicating it may have chemopreventive properties. Apr 02, 2010

Pubmed Data : Biochem Biophys Res Commun. 2010 Apr 2;394(2):360-5. Epub 2010 Mar 6. PMID: 20935227
Article Published Date : Apr 02, 2010
Study Type : Human Study
Additional Links
Substances : Resveratrol
Diseases : Cancers: All, Insulin-like Growth Factor (IGF): Elevated
Pharmacological Actions : Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords : Stilbenes
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Soy phytoestrogen has a positive effect on bone turnover indicators in menopausal women with osteopenia. Dec 01, 1999

Pubmed Data : Hum Cell. 1999 Dec;12(4):189-96. PMID: 16255781
Article Published Date : Dec 01, 1999
Study Type : Human Study
Additional Links
Substances : phytoestrogens, Soy Protein
Diseases : Osteopenia, Osteoporosis, Postmenopausal Disorders
Pharmacological Actions : Insulin-Like Growth Factor Inhibition/Downregulation
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Dry beans inhibit rat mammary carcinogenesis in a dose-dependent fashion. Nov 01, 2008

Pubmed Data : J Nutr. 2008 Nov;138(11):2091-7. PMID: 18936203
Article Published Date : Nov 01, 2008
Study Type : Animal Study
Additional Links
Substances : Beans: All
Diseases : Breast Cancer, C-Reactive Protein
Pharmacological Actions : Insulin-Like Growth Factor Inhibition/Downregulation, Interleukin-6 Downregulation
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Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and reduces insulin-like growth factor activity. Feb 20, 2004

Pubmed Data : Int J Cancer. 2004 Feb 20;108(5):733-40. PMID: 14696100
Article Published Date : Feb 20, 2004
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Diseases : Prostate Cancer
Pharmacological Actions : Anti-Angiogenic, Anticarcinogenic Agents, Antiproliferative , Apoptotic, Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords : Plant Extracts
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Influence of the maternal high-intensity-interval-training on the cardiac Sirt6 and lipid profile of the adult male offspring in rats.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2020 ;15(8):e0237148. Epub 2020 Aug 3. PMID: 32745152
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Cardiovascular Diseases
Pharmacological Actions : Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords : Epigenetic Inheritance, Transgenerational inheritance
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Inositol hexaphosphate suppresses hormone-refractory prostate cancer growth. Jan 01, 2004

Pubmed Data : Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):244-50. PMID: 14734476
Article Published Date : Jan 01, 2004
Study Type : Transgenic Animal Study
Additional Links
Substances : Inositol Hexaphosphate
Diseases : Prostate Cancer
Pharmacological Actions : Apoptotic, Insulin-Like Growth Factor Inhibition/Downregulation, Vascular Endothelial Growth Factor A Inhibitor
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Silibinin suppresses advanced human prostate cancer growth in athymic mice through reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis.Sep 01, 2003

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):933-9. PMID: 14504208
Article Published Date : Sep 01, 2003
Study Type : Animal Study
Additional Links
Substances : Milk Thistle, Silibinin
Diseases : Prostate Cancer
Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Apoptotic, Insulin-Like Growth Factor Inhibition/Downregulation, Vascular Endothelial Growth Factor A Inhibitor
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Soy phytochemicals prevent growth and metastasis of bladder cancer in mice. Feb 01, 2006

Pubmed Data : Cancer Res. 2006 Feb 1;66(3):1851-8. PMID: 16452247
Article Published Date : Feb 01, 2006
Study Type : Animal Study
Additional Links
Substances : Daidzein, Genistein, Isoflavones
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Cell cycle arrest, Insulin-Like Growth Factor Inhibition/Downregulation, NF-kappaB Inhibitor
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Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer resulting in cancer inhibition and programmed cell death. Mar 01, 2009

Pubmed Data : Mol Carcinog. 2009 Mar;48(3):243-52. PMID: 18726972
Article Published Date : Mar 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Apigenin
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Insulin-Like Growth Factor Inhibition/Downregulation
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CLA inhibits cell proliferation and increases programmed cell death in human bladder cancer cells. Feb 01, 2010

Pubmed Data : J Med Food. 2010 Feb;13(1):13-9. PMID: 20136431
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
Diseases : Bladder Cancer
Pharmacological Actions : Apoptotic, Insulin-Like Growth Factor Inhibition/Downregulation
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CLA inhibits the growth of human colon cancer cells via the downregulation of IGF-1 receptor levels. Aug 01, 2003

Pubmed Data : J Nutr. 2003 Aug;133(8):2675-81. PMID: 12888657
Article Published Date : Aug 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : CLA (Conjugated Linoleic Acid)
Diseases : Colon Cancer
Pharmacological Actions : Insulin-Like Growth Factor Inhibition/Downregulation
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Curcumin enhances the effects of 5-fluorouracil and oxaliplatin (FOLFOX) in mediating growth inhibition of colon cancer cells.Jan 15, 2008

Pubmed Data : Int J Cancer. 2008 Jan 15;122(2):267-73. PMID: 17918158
Article Published Date : Jan 15, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Cyclooxygenase 2 Inhibitors, Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords : Drug: 5-flourouracil, Drug-Plant-Vitamin Synergies
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Genistein inhibits cell proliferation and increases programmed cell death in human colon cancer cells. Jan 01, 2005

Pubmed Data : J Med Food. 2005;8(4):431-8. PMID: 16379552
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Genistein, Isoflavones
Diseases : Colon Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Insulin-Like Growth Factor Inhibition/Downregulation
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The anti-breast cancer activity of curcumin may be due in part to its down-regulation of insulin-like growth factor. May 16, 2007

Pubmed Data : Life Sci. 2007 May 16;80(23):2161-9. Epub 2007 Apr 21. PMID: 17499312
Article Published Date : May 16, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer, Insulin-like Growth Factor (IGF): Elevated
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Insulin-Like Growth Factor Inhibition/Downregulation
Additional Keywords : Drug Synergy

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