Interleukin-1 alpha downregulation

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65 Substances Researched for Interleukin-1 alpha downregulation
NameACCKFocus
Omega-3 Fatty Acids212Locked
DHA (Docosahexaenoic Acid)211Locked
Eicosapentaenoic acid (EPA) 110Locked
Fermented Foods and Beverages110Locked
Japanese cypress110Locked
Milk Thistle110Locked
Olive Oil110Locked
Sinomenine110Locked
Tea Tree110Locked
Resveratrol49Locked
Myricetin34Locked
Avocado33Locked
Carbon 6013Locked
Flavonoids23Locked
Fucoidan13Locked
Pterostilbene13Locked
Alpha-Lipoic Acid12Locked
Bee Venom12Locked
Berberine22Locked
Bergamot12Locked
Betulinic acid12Locked
Biochanin A12Locked
Carnosine12Locked
Cryptoxanthin12Locked
Curcumin12Locked
Cyanidin 3-glucoside12Locked
Fisetin12Locked
Ginkgo biloba12Locked
Hawthorn12Locked
Mussel: Green-lipped (Perna canaliculus)12Locked
Myrrh12Locked
Punicalagin12Locked
Purslane12Locked
Reishi Mushroom12Locked
Rice Bran12Locked
Sea buckthorn12Locked
Sesame Seed Oil 12Locked
Silibinin12Locked
Silver (nanoparticles)12Locked
Soy22Locked
St. Johns Wort12Locked
Thymoquinone12Locked
Unsaponifiables 22Locked
Vitamin C12Locked
Amla Fruit11Locked
Bitter Apple11Locked
Blackberry11Locked
Boneset11Locked
Boswellia11Locked
Cannabidiol11Locked
Carotenoids11Locked
Celastrol11Locked
Cucumber11Locked
Dandelion 11Locked
Ginsenosides11Locked
Lutein11Locked
Lycopene11Locked
MSM (Methylsulfonylmethane)11Locked
Parthenolide11Locked
Polyphenols11Locked
Quercetin11Locked
Scopoletin11Locked
Soybean: Black 11Locked
Vitamin D11Locked
Zeaxanthin11Locked

View the Evidence:
67 Abstracts with Interleukin-1 alpha downregulation Research

[+]

Effect of yoga therapy on disease activity, inflammatory markers, and heart rate variability in patients with rheumatoid arthritis.Apr 22, 2020

Pubmed Data : J Altern Complement Med. 2020 Apr 23. Epub 2020 Apr 23. PMID: 32326727
Article Published Date : Apr 22, 2020
Study Type : Human Study
Additional Links
Diseases : Rheumatoid Arthritis
Therapeutic Actions : Yoga
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lactobacillus-fermented Chamaecyparis obtusa treatment was rapid and effective for treating acne lesions compared to tea tree oil.Dec 31, 2013

Pubmed Data : Dermatology. 2014 ;229(2):102-9. Epub 2014 Sep 6. PMID: 25228478
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Substances : Fermented Foods and Beverages, Japanese cypress, Tea Tree
Diseases : Acne
Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-8 downregulation
Additional Keywords : Phytotherapy
[+]

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis. Jul 01, 2009

Pubmed Data : Osteoarthritis Cartilage. 2009 Jul;17(7):896-905. Epub 2009 Jan 13. PMID: 19217322
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Substances : DHA (Docosahexaenoic Acid), Eicosapentaenoic acid (EPA) , Omega-3 Fatty Acids
Diseases : Osteoarthritis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Positive effects of extra-virgin olive oil supplementation and DietBra on inflammation and glycemic profiles.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Endocrinol (Lausanne). 2022 ;13:841971. Epub 2022 May 2. PMID: 35586621
Article Published Date : Dec 31, 2021
Study Type : Human Study
Additional Links
Substances : Olive Oil
Diseases : Diabetes Mellitus: Type 2, Obesity
Pharmacological Actions : Adiponectin Down-Regulation, Anti-Inflammatory Agents, Interleukin-1 alpha downregulation
[+]

Silymarin has anti-inflammatory activity superior to the drugs piroxicam and meloxicam in the treatment of osteoarthritis of the knee. Mar 10, 2010

Pubmed Data : J Proteomics. 2010 Mar 10;73(5):951-64. Epub 2010 Jan 4. PMID: 19139781
Article Published Date : Mar 10, 2010
Study Type : Human Study
Additional Links
Substances : Milk Thistle
Diseases : Osteoarthritis, Osteoarthritis: Knee
Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-8 downregulation
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Sinomenine inhibits the progression of rheumatoid arthritis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2018 ;9:2228. Epub 2018 Sep 26. PMID: 30319663
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Sinomenine
Diseases : Arthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-12 downregulation, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Resveratrol may be a useful preventative therapeutic for pregnancies complicated by inflammation and insulin resistance.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2017 ;12(3):e0173373. Epub 2017 Mar 9. PMID: 28278187
Article Published Date : Dec 31, 2016
Study Type : Human In Vitro
Additional Links
Substances : Resveratrol
Diseases : Gestational Diabetes, Inflammation, Pregnancy Complications
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.Oct 04, 2022

Pubmed Data : Int J Biol Macromol. 2022 Oct 5. Epub 2022 Oct 5. PMID: 36208806
Article Published Date : Oct 04, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anticancer investigation of fullerene C60 on DMBA induced breast cancer.Feb 14, 2022

Pubmed Data : Life Sci. 2022 Feb 15 ;291:120281. Epub 2022 Jan 1. PMID: 34982963
Article Published Date : Feb 14, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carbon 60
Diseases : Breast Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antioxidants, Apoptotic, Cyclooxygenase 2 Inhibitors, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation
[+]

Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells.Jan 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2015 Feb ;35(2):383-90. Epub 2014 Dec 9. PMID: 25503577
Article Published Date : Jan 31, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Diseases : Aging Skin
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 alpha downregulation
[+]

Pterostilbene interferes with lipopolysaccharide-induced myocardial injury,Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2022 ;13:862187. Epub 2022 Mar 24. PMID: 35399278
Article Published Date : Dec 31, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Ganoderma lucidum polysaccharides protect against sepsis-induced cardiac dysfunction by activating SIRT1.Sep 23, 2021

Pubmed Data : J Pharm Pharmacol. 2021 Sep 24. Epub 2021 Sep 24. PMID: 34559876
Article Published Date : Sep 23, 2021
Study Type : Animal Study
Additional Links
Substances : Reishi Mushroom
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, SIRT1 Activator, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A sesame oil enriched diet could be an effective nonpharmacological treatment for atherosclerosis by controlling inflammation and regulating lipid metabolism.Dec 31, 2014

Pubmed Data : J Med Food. 2015 Jan ;18(1):11-20. PMID: 25562618
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Sesame Seed Oil
Diseases : Atherosclerosis, Inflammation
Pharmacological Actions : Anti-atherogenic, Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation
[+]

Anti-inflammatory effect and potential mechanism of betulinic acid on λ-carrageenan-induced paw edema in mice.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Oct ;118:109347. Epub 2019 Aug 16. PMID: 31545273
Article Published Date : Sep 30, 2019
Study Type : Animal Study
Additional Links
Substances : Betulinic acid
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-5 downregulation, Interleukin-6 Downregulation
[+]

Antioxidative attributes of rice bran extracts in ameliorative effects of atherosclerosis-associated risk factors.Nov 30, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2020 Dec ;6(12):e05743. Epub 2020 Dec 21. PMID: 33376820
Article Published Date : Nov 30, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Rice Bran
Diseases : Atherosclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Attenuation of lipid metabolic abnormalities, proinflammatory cytokines, and matrix metalloproteinase expression by biochanin.Mar 14, 2021

Pubmed Data : Drug Chem Toxicol. 2021 Mar 15:1-12. Epub 2021 Mar 15. PMID: 33719799
Article Published Date : Mar 14, 2021
Study Type : Animal Study
Additional Links
Substances : Biochanin A
Diseases : Myocardial Infarction
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Hypolipidemic, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Bee venom prevents cholecystokinin-induced acute pancreatitis in rats.Mar 01, 2008

Pubmed Data : Pancreas. 2008 Mar;36(2):e22-9. PMID: 18376296
Article Published Date : Mar 01, 2008
Study Type : Animal Study
Additional Links
Substances : Bee Venom
Diseases : Pancreatitis
Pharmacological Actions : Anti-Inflammatory Agents, Heat Shock Protein Inducer, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Beneficial effect of long-chain n-3 polyunsaturated fatty acid supplementation on tuberculosis.May 25, 2021

Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 2021 May 26 ;170:102304. Epub 2021 May 26. PMID: 34082319
Article Published Date : May 25, 2021
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Tuberculosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation
[+]

Curcumin can act as a suitable therapeutic agent against sepsis-induced chronic lung injury.Dec 31, 2016

Pubmed Data : J Nutr Health Aging. 2017 ;21(3):307-313. PMID: 28244571
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Lipid Peroxidation, Lung Injury: Acute, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 alpha downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Cyanidin-3-O-glucoside ameliorates diabetic nephropathy through regulation of glutathione pool.Jun 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1223-1230. Epub 2018 May 7. PMID: 29864902
Article Published Date : Jun 30, 2018
Study Type : Animal Study
Additional Links
Substances : Cyanidin 3-glucoside
Diseases : Diabetic Nephropathy, Hyperglycemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Effect of carnosine and α-lipoic acid on hepatocyte apoptosis and the cytokine profile in induced fatty liver disease.Dec 31, 2019

Pubmed Data : Vopr Pitan. 2020;89(5):6-16. Epub 2020 Sep 20. PMID: 33211913
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid, Carnosine
Diseases : Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-10 upregulation, Interleukin-17 downregulation, Interleukin-1 alpha downregulation
[+]

Essential oil and juice from bergamot and sweet orange improve acne vulgaris.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2020 ;2020:8868107. Epub 2020 Oct 6. PMID: 33082712
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Bergamot
Diseases : Acne
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation
Additional Keywords : Essential Oils
[+]

Fisetin loaded binary ethosomes for management of skin cancer by dermal application on UV exposed mice.Apr 04, 2019

Pubmed Data : Int J Pharm. 2019 Apr 5 ;560:78-91. Epub 2019 Feb 10. PMID: 30742987
Article Published Date : Apr 04, 2019
Study Type : Animal Study
Additional Links
Substances : Fisetin
Diseases : Skin Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemotherapeutic, Interleukin-1 alpha downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginkgolide B mediated alleviation of inflammatory cascades and altered lipid metabolism.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:7284767. Epub 2019 Jun 10. PMID: 31281844
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Atherosclerosis, Cholesterol: Oxidation, Inflammation
Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Green mussel extract decreases the production of cytokines associated with inflammation.Dec 01, 2008

Pubmed Data : Eur Ann Allergy Clin Immunol. 2008 Dec;40(4):148-53. PMID: 19227651
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Mussel: Green-lipped (Perna canaliculus)
Diseases : Arthritis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Adjuvant-Induced Injury
[+]

Hawthorn fruit, especially its peel, is an excellent source of natural chemopreventive agents in the treatment of liver disorders.Aug 12, 2016

Pubmed Data : Chem Biol Interact. 2016 Aug 13. Epub 2016 Aug 13. PMID: 27531227
Article Published Date : Aug 12, 2016
Study Type : Animal Study
Additional Links
Substances : Hawthorn
Diseases : Dyslipidemias, High Fructose Diet, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Hypericum perforatum may improve anxiety-like behaviour and offer brain protection by modulation of oxidative stress and inflammation.Sep 30, 2018

Pubmed Data : J Physiol Pharmacol. 2018 Oct ;69(5). Epub 2019 Jan 21. PMID: 30683830
Article Published Date : Sep 30, 2018
Study Type : Animal Study
Additional Links
Substances : St. Johns Wort
Diseases : Anxiety, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Anxiety Agents, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation
Additional Keywords : Plant Extracts
[+]

Intravenous laser wavelength irradiation effect on interleukins: IL-1α, IL-1β, IL6 in diabetic rats.Dec 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Laser Ther. 2019 Dec 31 ;28(4):267-273. PMID: 32255918
Article Published Date : Dec 30, 2019
Study Type : Animal Study
Additional Links
Diseases : Inflammation
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Myrrh oil has anti-inflammatory properties. Mar 01, 2006

Pubmed Data : Toxicol In Vitro. 2006 Mar;20(2):248-55. Epub 2005 Aug 19. PMID: 16112536
Article Published Date : Mar 01, 2006
Study Type : Animal Study
Additional Links
Substances : Myrrh
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Prostaglandin Antagonists
[+]

Oral administration of punicalagin attenuates imiquimod-induced psoriasis.Jan 31, 2024

Pubmed Data : Phytother Res. 2024 Feb ;38(2):713-726. Epub 2023 Nov 27. PMID: 38009260
Article Published Date : Jan 31, 2024
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Inflammation, Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-22 Downregulation, Interleukin-23 Downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Photobiomodulation restores spermatogenesis in the transient scrotal hyperthermia-induced mice.Jul 31, 2020

Pubmed Data : Life Sci. 2020 Aug 1 ;254:117767. Epub 2020 May 11. PMID: 32407848
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Diseases : Infertility: Male, Oxidative Stress
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Anti-Inflammatory Agents, Fertility Agents: Male, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Portulaca extract can be a potential candidate for the treatment of inflammatory bowel disease.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PPAR Res. 2018 ;2018:6079101. Epub 2018 Feb 1. PMID: 29483924
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Purslane
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effect of silibinin on lipopolysaccharide-induced endotoxemia.Mar 26, 2024

Pubmed Data : Chin J Integr Med. 2024 Mar 27. Epub 2024 Mar 27. PMID: 38532152
Article Published Date : Mar 26, 2024
Study Type : Animal Study
Additional Links
Substances : Silibinin
Diseases : Endotoxemia, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation
[+]

Resveratrol inhibits the inflammatory process associated with severe acute pancreatitis.Oct 01, 1996

Pubmed Data : Planta Med. 1996 Oct;62(5):405-9. PMID: 16389574
Article Published Date : Oct 01, 1996
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Pancreatitis, Pancreatitis: Acute Necrotizing
Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The observations of the study illustrate the protective effects of myricetin in glaucomatous trabecular meshwork cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Neurosci. 2018 ;9:132-141. Epub 2018 Nov 12. PMID: 30473883
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Myricetin
Diseases : Glaucoma
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The results suggest that systemic administration of vitamin C could be clinically beneficial in improving periodontitis-induced oxidative stress.Jan 14, 2009

Pubmed Data : Free Radic Biol Med. 2009 Jan 15 ;46(2):163-8. Epub 2008 Oct 21. PMID: 18983910
Article Published Date : Jan 14, 2009
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Oxidative Stress, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation
[+]

This is the first in vivo report demonstrating antiviral activity of silver nanoparticles during respiratory syncytial virus infection.Aug 07, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Viruses. 2019 Aug 8 ;11(8). Epub 2019 Aug 8. PMID: 31398832
Article Published Date : Aug 07, 2019
Study Type : Animal Study
Additional Links
Substances : Silver (nanoparticles)
Diseases : Respiratory Syncytial Virus Infections
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Immunomodulatory, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymoquinone prevents sequels of the multiple organ failure syndrome of sepsis by modulating the production of NO and its inflammatory sequela.Aug 14, 2015

Pubmed Data : Life Sci. 2015 Aug 15. Epub 2015 Aug 15. PMID: 26285172
Article Published Date : Aug 14, 2015
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-1 alpha downregulation, Interleukin-2 Downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor
[+]

Topical application of total flavonoids of Hippophae rhamnoides improved atopic dermatitis-like lesions.Mar 15, 2022

Pubmed Data : J Ethnopharmacol. 2022 Mar 16 ;292:115195. Epub 2022 Mar 16. PMID: 35306042
Article Published Date : Mar 15, 2022
Study Type : Animal Study
Additional Links
Substances : Flavonoids, Sea buckthorn
Diseases : Atopic Dermatitis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

β-cryptoxanthin may be useful in blocking the progression of rheumatoid arthritis and osteoarthritis.Jan 04, 2016

Pubmed Data : Biochem Biophys Res Commun. 2016 08 5 ;476(4):352-358. Epub 2016 May 27. PMID: 27240953
Article Published Date : Jan 04, 2016
Study Type : Animal Study
Additional Links
Substances : Cryptoxanthin
Diseases : Osteoarthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation
[+]

A small molecule compound berberine as an orally active therapeutic candidate against COVID-19 and SARS.Mar 31, 2021

Pubmed Data : FASEB J. 2021 Apr ;35(4):e21360. PMID: 33749932
Article Published Date : Mar 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Anti-inflammatory activity of Eupatorium perfoliatum L. extracts.Aug 31, 2011

Pubmed Data : J Ethnopharmacol. 2011 Sep 1 ;137(1):371-81. Epub 2011 Jun 6. PMID: 21669270
Article Published Date : Aug 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Boneset
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation
Additional Keywords : Plant Extracts
[+]

Anti-inflammatory properties of narrow-band blue light.Dec 31, 2005

Pubmed Data : J Drugs Dermatol. 2006 ;5(7):605-10. PMID: 16865864
Article Published Date : Dec 31, 2005
Study Type : In Vitro Study
Additional Links
Diseases : Acne, Inflammation
Therapeutic Actions : Photobiomodulation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation
[+]

Avocado/soy unsaponifiables have a protective effect against inflammation within articular chondrocytes.Jun 01, 2008

Pubmed Data : Evid Based Complement Alternat Med. 2008 Jun;5(2):191-7. PMID: 18604259
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Avocado, Soy, Unsaponifiables
Diseases : Osteoarthritis
Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Prostaglandin Antagonists
[+]

Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell.Aug 13, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2019 Aug 14 ;19(1):216. Epub 2019 Aug 14. PMID: 31412862
Article Published Date : Aug 13, 2019
Study Type : In Vitro Study
Additional Links
Substances : Berberine
Diseases : Breast Cancer: Triple Negative , Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Blackberry leaf extract contains phytonutrients that prevent wrinkle formation.Oct 01, 2007

Pubmed Data : Int J Cosmet Sci. 2007 Oct;29(5):411. PMID: 18489379
Article Published Date : Oct 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Blackberry
Diseases : Aging Skin
Pharmacological Actions : Interleukin-1 alpha downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]

Boswellia's immunomodulatory properties may make it ideal for the treatment of autoimmune and inflammatory diseases.Sep 01, 2010

Pubmed Data : Phytomedicine. 2010 Sep;17(11):862-7. Epub 2010 Aug 8. PMID: 20696559
Article Published Date : Sep 01, 2010
Study Type : Review
Additional Links
Substances : Boswellia
Diseases : Arthritis: Rheumatoid, Asthma: Bronchial, Autoimmune Diseases, Colitis: Ulcerative, Crohn's Disease, Inflammatory Bowel Diseases, Osteoarthritis
Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-2 Downregulation, Interleukin-4 downregulation, Interleukin-6 Downregulation, Leukotriene Antagonists, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Celastrol pyrazine derivative alleviates silicosis progression.Jan 21, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2024 Jan 22 ;29(2). Epub 2024 Jan 22. PMID: 38276616
Article Published Date : Jan 21, 2024
Study Type : In Vitro Study
Additional Links
Substances : Celastrol
Diseases : Inflammation, Silicosis
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Cucumis sativus L. extract attenuated lipopolysaccharide-induced inflammatory response in endothelial cells.Jun 24, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2018 Jun 25 ;18(1):194. Epub 2018 Jun 25. PMID: 29941006
Article Published Date : Jun 24, 2018
Study Type : In Vitro Study
Additional Links
Substances : Cucumber
Diseases : Alcohol Toxicity , Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-18 upregulation, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation
Additional Keywords : Plant Extracts
[+]

Dandelion inhibits inflammation in rat astrocytes, indicating it may have antiinflammatory activity in the central nervous system. Aug 01, 2000

Pubmed Data : Immunopharmacol Immunotoxicol. 2000 Aug;22(3):519-30. PMID: 10946829
Article Published Date : Aug 01, 2000
Study Type : In Vitro Study
Additional Links
Substances : Dandelion
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Dietary supplement with avocado and soybean unsaponifiables modulates osteoarthritis pathogenesis by inhibiting a number of molecules and pathways.Dec 31, 2014

Pubmed Data : Cartilage. 2015 Jan ;6(1):30-44. PMID: 25621100
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Avocado, Soybean: Black
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Significant Treatment Outcome
[+]

Docosahexaenoic acid (DHA) reduces LPS-induced inflammatory response.Nov 12, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2023 Nov 13 ;57(6):411-425. PMID: 37962278
Article Published Date : Nov 12, 2023
Study Type : In Vitro Study
Additional Links
Substances : DHA (Docosahexaenoic Acid)
Diseases : Cerebral Ischemia, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Neuroprotective Agents
[+]

Ginsenoside Rh2 may be considered as a potential therapeutic candidate for chronic inflammatory diseases.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:646728. Epub 2013 Feb 17. PMID: 23483870
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Interleukin-1 alpha downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Health benefits of polyphenols and carotenoids in age-related eye diseases.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:9783429. Epub 2019 Feb 12. PMID: 30891116
Article Published Date : Dec 31, 2018
Study Type : Review
Additional Links
Substances : Carotenoids, Lutein, Polyphenols, Quercetin, Resveratrol, Zeaxanthin
Diseases : Cataract, Diabetic Retinopathy, Eye Diseases, Glaucoma, Macular Degeneration
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation
[+]

Lycopene ameliorates propionic acid-induced autism spectrum disorders by inhibiting inflammation and oxidative stress.Sep 01, 2021

Pubmed Data : J Food Biochem. 2021 Sep 2:e13922. Epub 2021 Sep 2. PMID: 34476820
Article Published Date : Sep 01, 2021
Study Type : In Vitro Study
Additional Links
Substances : Lycopene
Diseases : Autism Spectrum Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 alpha downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Methylsulfonylmethane inhibits NLRP3 inflammasome activation.Jan 31, 2015

Pubmed Data : Cytokine. 2015 Feb ;71(2):223-31. Epub 2014 Nov 21. PMID: 25461402
Article Published Date : Jan 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : MSM (Methylsulfonylmethane)
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Myricetin inhibits SARS-CoV-2 viral replication.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:669642. Epub 2021 Jun 17. PMID: 34220507
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Antiviral Agents, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Parthenolide ameliorates fibrogenesis and inflammation in hepatic fibrosis.Sep 30, 2021

Pubmed Data : Phytother Res. 2021 Oct ;35(10):5680-5693. Epub 2021 Jul 12. PMID: 34250656
Article Published Date : Sep 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Inflammation, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-18 down-regulation, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Potential of cannabidiol as acne and acne scar treatmentJun 20, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arch Dermatol Res. 2024 Jun 21 ;316(7):428. Epub 2024 Jun 21. PMID: 38904694
Article Published Date : Jun 20, 2024
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Acne
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation
[+]

Protective effect and mechanism research of Phyllanthus emblica Linn. fruit extract on UV-induced photodamage.Apr 18, 2023

Pubmed Data : Photochem Photobiol Sci. 2023 Apr 19. Epub 2023 Apr 19. PMID: 37076760
Article Published Date : Apr 18, 2023
Study Type : In Vitro Study
Additional Links
Substances : Amla Fruit
Diseases : Aging Skin, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Photoprotective
[+]

Resveratrol may have a significant role in the treatment of severe acute pancreatitis.Jan 01, 2010

Pubmed Data : Front Biosci (Schol Ed). 2010;2:168-75. Epub 2010 Jan 1. PMID: 20036937
Article Published Date : Jan 01, 2010
Study Type : Commentary
Additional Links
Substances : Resveratrol
Diseases : Pancreatitis, Pancreatitis: Acute Necrotizing
Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Scopoletin downregulates MMP‑1 expression in human fibroblasts via inhibition of p38 phosphorylation.Sep 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Med. 2018 Oct ;42(4):2285-2293. Epub 2018 Jul 4. PMID: 30015831
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Scopoletin
Diseases : Aging Skin
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The anticancer efficiency of Citrullus colocynthis toward the colorectal cancer therapy.Aug 28, 2019

Pubmed Data : J Gastrointest Cancer. 2019 Aug 29. Epub 2019 Aug 29. PMID: 31463888
Article Published Date : Aug 28, 2019
Study Type : In Vitro Study
Additional Links
Substances : Bitter Apple
Diseases : Colorectal Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anti-metastatic, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Wnt/β-catenin signaling pathway modulation
[+]

The studies suggested that baicalin had obvious protective effect on HBMECs damaged by oxygen-glucose deprivation.Sep 30, 2020

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2020 Oct ;45(19):4686-4691. PMID: 33164433
Article Published Date : Sep 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results enrich the comprehensive bioactivities of myricetin and reveal that it has powerful anti-inflammatory properties.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2019 ;2019:3746326. Epub 2019 Mar 7. PMID: 30956980
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-2 Downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Unsaponifiable extracts of avocado and soybean may inhibit the deleterious effects of interleukin-1 in osteoarticular diseases. Apr 01, 1991

Pubmed Data : Rev Rhum Mal Osteoartic. 1991 Apr;58(4):241-5. PMID: 1647544
Article Published Date : Apr 01, 1991
Study Type : In Vitro Study
Additional Links
Substances : Avocado, Soy, Unsaponifiables
Diseases : Osteoarthritis, Rheumatoid Arthritis
Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation
Additional Keywords : Plant Extracts
[+]

Vitamin D has the ability to suppress inflammatory cytokines, while it increases the generation of anti-inflammatory cytokines.Jun 30, 2015

Pubmed Data : J Biol Regul Homeost Agents. 2015 Jul-Sep;29(3):563-7. PMID: 26403394
Article Published Date : Jun 30, 2015
Study Type : Review
Additional Links
Substances : Vitamin D
Diseases : Skin Diseases: Inflammatory
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-1 alpha downregulation, Interleukin-2 Downregulation, Interleukin-4 upregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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