Interleukin-1 beta downregulation

Name	AC	CK
Flavonoids	162	290
Ginsenosides	92	160
Curcumin	76	155
Berberine	55	133
Resveratrol	43	104
Paeoniflorin	49	94
Polyphenols	38	83
Astragaloside	42	72
Vitamin D	15	69
Astaxanthin	30	62
Sinomenine	19	59
Probiotics	12	56
Ginkgo biloba	30	53
Quercetin	30	53
Tanshinone IIA	32	53
EGCG (Epigallocatechin gallate)	18	52
Lactoferrin	11	51
Paeonol	30	51
Safflower	25	51
Hesperidin	25	47
Vitamin C	16	47
Puerarin	25	46
Melatonin	22	42
Thymoquinone	22	42
Goji	20	40
Lactobacillus plantarum	22	39
Omega-3 Fatty Acids	8	39
Piperine	13	36
Emodin	21	35
Green Tea	11	35
Luteolin	22	35
Punicalagin	13	35
Ginger	18	34
Hydrogen Water	17	34
Icariin	10	34
Sulforaphane	20	33
Anthocyanins	11	32
Chrysin	17	32
Dandelion	19	32
Fermented Foods and Beverages	20	32
Fisetin	17	32
Apigenin	18	31
Salvia miltiorrhiza	16	31
Ursolic Acid	7	31
Honokiol	17	30
Ellagic Acid	14	29
Fucoidan	18	29
Lycopene	16	29
Cannabidiol	19	28
Citrus naringin	19	28
Pterostilbene	14	28
Rose	17	28
Catechin	6	27
Frankincense	11	27
Palmitoylethanolamide	11	27
Peony	14	27
Biochanin A	14	26
Crocin	15	26
Gastrodin	15	26
Naringenin	16	26
Dogwood	15	25
Echinacea	9	25
Rosmarinic acid	12	25
Shikonin	14	25
Burdock	12	24
Leonurine	10	24
Phloretin	11	24
Reishi Mushroom	16	24
Bee Venom	8	23
Honey	6	23
Lactobacillus rhamnosus	5	23
Nobiletin	14	23
Olive leaf extract	9	23
Betulinic acid	10	22
Black Tea	8	22
Celastrol	12	22
Cinnamaldehyde	8	22
Moringa oleifera	14	22
Rutin	12	22
Silibinin	8	22
Almond	3	21
Asiatic Acid	14	21
DHA (Docosahexaenoic Acid)	3	21
Diosgenin	10	21
Lotus	13	21
Magnolol	11	21
Patchouli	13	21
Saffron	6	21
Yoghurt	3	21
Coenzyme Q10	6	20
Formononetin	11	20
Hydrogen: Molecular	10	20
Licorice	12	20
Fucoxanthin	10	19
Gingerol	11	19
Lutein	6	19
Mangiferin	12	19
Saikosaponin	12	19
Tangeretin	11	19
Wogonin	13	19
6-Shogaol	9	18
Andrographis	11	18
Chaga Mushroom (Inonotus obliquus)	10	18
Chlorogenic Acid	10	18
Honeysuckle	12	18
Isoliquiritigenin	11	18
Lactobacillus reuteri	5	18
Mulberry	10	18
Allicin	10	17
Bromelain	5	17
Carnosic Acid	9	17
Diosmin	11	17
Glycyrrhizin	12	17
Kefir	9	17
Lion's Mane (Hericium Erinaceus)	9	17
Medicinal Mushrooms	9	17
Rosemaric Acid	9	17
Syringic Acid	10	17
Vitexins	8	17
Aloe Vera	8	16
Carvacrol	10	16
Cordyceps Militaris	8	16
Ferulic acid	8	16
Geraniol	9	16
Grape Seed Extract	8	16
Hemp Seed	6	16
Kaempferol	10	16
Myricetin	10	16
Oleuropein	9	16
Panax Notoginseng	9	16
Parthenolide	10	16
Sea buckthorn	9	16
Sesamin	4	16
Bee Propolis	5	15
Gotu Kola	10	15
Lactobacillus delbrueckii Subsp	1	15
Nigella sativa (aka Black Seed)	4	15
Andrographolide	9	14
Beta-Caryophyllene	9	14
Crocetin	8	14
Cyanidin 3-glucoside	3	14
Folic Acid	3	14
Genipin	8	14
Grape	4	14
Jujube	8	14
Pine Bark Extract	3	14
Pomegranate Peel	3	14
Spirulina	3	14
Stilbenes	7	14
Sweet Potato: Purple	7	14
Tart Cherry	3	14
Turmeric	10	14
Urolithin A	9	14
Vitamin B-6	3	14
Vitamin E	3	14
Blueberry	8	13
Garlic	8	13
Ginseng (Korean)	7	13
Mangosteen	3	13
NAC (N-acetyl-L-cysteine)	7	13
Perilla	8	13
Plumbagin	7	13
Poria cocos	8	13
Psilocybin	3	13
Purslane	7	13
Strawberry	3	13
Walnut	8	13
Watercress	3	13
Bilberry	3	12
Bitter Melon	7	12
Eugenol	8	12
FOS (Fructooligosaccharides)	2	12
Hawthorn	7	12
Ketone Bodies	2	12
Maqui	2	12
Neem	9	12
Oyster Mushroom	2	12
Pomegranate	7	12
Royal Jelly	7	12
Sesamol	8	12
Ashwagandha	7	11
Baicalein	6	11
Guduchi	7	11
Lactobacillus Acidophilus	5	11
Procyanidin B2	8	11
Seaweed	2	11
Amygdalin	5	10
Apocynin	5	10
Artesunate	6	10
Bacillus coagulans	1	10
Betaine	1	10
Bloodroot	1	10
Breast Milk	1	10
Cucurbitacin B	6	10
Delphinidin	1	10
Diosmetin	4	10
Eicosapentaenoic acid (EPA)	1	10
Horse Chestnut	6	10
Inulin	1	10
Olive	1	10
Prune	1	10
Prunella vulgaris	5	10
Selenium	6	10
Virgin Coconut Oil	1	10
Vitamin A	1	10
Whey	6	10
Zinc	1	10
Alpha-Lipoic Acid	6	9
Arctigenin	5	9
Chrysanthemum Indicum	5	9
Fig	3	9
Huperzine	5	9
Isoflavones	6	9
Lactobacillus probiotics	4	9
Red Sage	5	9
Astragalus	4	8
Black Currant	4	8
Caffeic acid phenethyl ester	5	8
Lactobacillus fermentum	4	8
Lactobacillus paracasei	4	8
Ligustrazine	4	8
Lupeol	4	8
Lychee	4	8
Myrrh	4	8
Myrtenol	4	8
Oligosaccharides	4	8
Phlorotannins	5	8
Raspberry	4	8
Seaweed: Brown	5	8
Terminalia	3	8
Theaflavins	4	8
Thymol	5	8
Verbascoside	4	8
Zerumbone	6	8
Bifidobacterium Bifidum	4	7
Black Raspberry	5	7
Chamomile	4	7
Chokeberry	5	7
Citrus Triterpenoids	3	7
Elm tree	3	7
Eriodictyol	6	7
Flaxseed	4	7
Genistein	4	7
Isothiocyanates	4	7
Orange	4	7
Persimmon	4	7
Piceatannol	4	7
Plantago	5	7
Propolis: Bee	4	7
Vanillic Acid	4	7
Vanillin	6	7
beta-Carotene	4	7
18β-Glycyrrhetinic Acid	3	6
Adlay	3	6
Agaricus Blazei	3	6
Amla Fruit	3	6
Bergamot	4	6
Caffeic Acid	3	6
Chinese Skullcap	3	6
Cordyceps sinensis	3	6
Cranberry	3	6
Dong Quai	3	6
Elderberry	3	6
Eucalyptus	3	6
Ginseng	3	6
Horsetail	3	6
Indigo naturalis	4	6
Kudzu	3	6
Lactobacillus casei	3	6
Lactobacillus rhamnosus GG	3	6
Lactobacillus salivarius	3	6
Oak	4	6
P-Coumaric Acid	4	6
Perillaldehyde	3	6
Piperlongumine	3	6
Schisandra	3	6
Scopoletin	3	6
Shitake Mushroom	4	6
Vinpocetine	3	6
acetyl-11-keto-beta-boswellic acid	4	6
Apple Polyphenols	3	5
Artichoke	3	5
Billygoat Weed	2	5
Chlorella (Algae)	3	5
Cucurbitacin E	4	5
Hops	3	5
Isothiocyanate	3	5
Japanese cypress	3	5
Kiwifruit	3	5
Krill	3	5
Lactobacillus Brevis	4	5
Lavender: Essential Oil	3	5
MSM (Methylsulfonylmethane)	3	5
Oleanolic acid	3	5
Orange: Mandarin	3	5
Oridonin	4	5
Papaya: Fermented	1	5
Plantago asiatica	3	5
Theanine	3	5
White Tea	3	5
Xanthohumol	3	5
Babchi	3	4
Bee Pollen	2	4
Bifidobacterium	2	4
Boron	2	4
Buckwheat	2	4
Carrageenans	2	4
Chicoric Acid	2	4
Chondroitin Sulfate	2	4
Citral	2	4
Citrus Peel	2	4
Daidzein	2	4
Elecampane	3	4
Fiber	2	4
Fish Oil	3	4
Gallic Acid	3	4
Germanium	3	4
Ginseng (American)	2	4
Ginseng (Siberian)	2	4
Guava	3	4
Gynostemma	3	4
Harmine	2	4
Hu Zhang (Polygonum cuspidatum)	2	4
Hydroxytyrosol	2	4
Indole-3-Carbinol	2	4
Lavender	2	4
Magnesium	2	4
Magnolia	2	4
Nicotinamide Mononucleotide	2	4
Oligonol	2	4
Peanut	2	4
Pectin	2	4
Phyllanthus amarus	3	4
Pine Needle	3	4
Rosemary	2	4
Shiitake Mushroom	2	4
Silymarin	2	4
Soursop	2	4
Soy	3	4
Spikenard	3	4
Tomatidine	2	4
Toona sinensis	2	4
Agrimony	2	3
Antrodia camphorata	2	3
Bai Zhu	2	3
Banana	2	3
Bay Laurel	2	3
Benzyl isothiocyanate	3	3
Beta Sitosterol	2	3
Beta-Elemene	2	3
Beta-glucan	1	3
Broccoli	2	3
Cannabichromene	1	3
Cannabis	2	3
Capsaicin	2	3
Cardamonin	3	3
Carnosol	2	3
Carotenoids	3	3
Chrysanthemum Morifolium	2	3
Cinnamon	2	3
Cissus quadrangularis	2	3
Diallyl sulfide	2	3
Fenugreek	2	3
Ganoderic acid	2	3
Garcinia kola	2	3
Hibiscus sabdariffa	2	3
Lactobacillus gasseri	2	3
Liquiritigenin	3	3
Mango	2	3
Manuka Honey	2	3
Oats	2	3
Oleocanthal	2	3
Organosulfur Compounds	1	3
Phenethyl isothiocyanate	2	3
Pomegranate flower	2	3
Psychedelics:All	2	3
Red Clover	2	3
Red Marine Algae	2	3
Rhubarb	2	3
Rice Bran	2	3
Safranal	2	3
Sarsaparilla	2	3
Silver (nanoparticles)	2	3
Skullcap: Chinese	1	3
Tea: Oolong	1	3
Thyme	3	3
Tripterygium wilfordii	2	3
Zataria multiflora	2	3
Zeaxanthin	2	3
Acai	1	2
Alpha Linolenic Acid	1	2
Amygdalin (laetrile)	2	2
Anemarrhena asphodeloides	1	2
Apple	1	2
Apple Cider Vinegar	1	2
Apples	1	2
Arginine	1	2
Artemisinin	1	2
Arugula	1	2
Aspen	1	2
Avocado	2	2
Bael	1	2
Bamboo	1	2
Barley	1	2
Basil: Sweet	2	2
Beans: All	1	2
Beet	1	2
Betel	1	2
Bifidobacterium Lactis	1	2
Bifidobacterium Longum	1	2
Bitter Orange	2	2
Blue Honeysuckle	1	2
Brown Rice	1	2
Brown Rice: Pre-Germinated	1	2
Bufalin	1	2
Butterfly Pea	1	2
Cabbage	1	2
Camel Milk	1	2
Cannabigerol	1	2
Cannabinoids	1	2
Carbon 60	1	2
Carnitine	1	2
Carnosine	1	2
Chaenomeles speciosa	1	2
Cherry: All Varieties	2	2
Chia	1	2
Citicoline	1	2
Citrus Oils	1	2
Coconut Oil	1	2
Combretum fragrans	1	2
Common bean	1	2
Corn: Purple	1	2
Curcumol	2	2
Curry Tree	1	2
Cystine	1	2
EPA (Eicosapentaenoic Acid)	1	2
Essential Oils: Unspecified	1	2
Flavan-3-ols	1	2
Ganoderic acid B	1	2
Garcinia Mangostana	1	2
Gardenia	1	2
Glucosamine	1	2
Glycyrrhiza uralensis	2	2
Gold (nanoparticles)	1	2
Goldenrod	1	2
Guarana	1	2
Helenalin	1	2
Henna	1	2
Hibiscus	2	2
Honeydew (melon)	1	2
Hyaluronic Acid	1	2
Indian Gooseberry	1	2
Ipriflavone	1	2
Japanese mugwort	1	2
Kaempferia parviflora	1	2
Kale	2	2
Kombucha Tea	1	2
Lactobacillus sakei	1	2
Lauric acid	1	2
Lettuce	1	2
Lignans	1	2
Loquat	1	2
Marigold	1	2
Modified Rice Bran (MGN-3)	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Mussel: Green-lipped (Perna canaliculus)	1	2
Nettle	1	2
Onion	1	2
Oolong tea	1	2
Orthosiphon	1	2
Oyster Mushroom: Indian	1	2
Papaya	1	2
Passion Flower	1	2
Passion fruit	1	2
Peppermint	1	2
Phellinus Linteus	2	2
Phyllanthus emblica	1	2
Pine Nut	1	2
Pipsisssewa	1	2
Policosanol	1	2
Porridge	1	2
Prickly Pear Cactus	1	2
Proanthocyanidins	1	2
Progesterone	1	2
Propolis: Brazillian	1	2
Pulsatilla pratensis	1	2
Pumpkin	1	2
Pumpkin Seeds	1	2
Pycnogenol (Pine Bark)	1	2
Quince	1	2
Radish	1	2
Rice	1	2
Rubia Cordifolia	1	2
Salicylic acid	2	2
Sea Cucumber	1	2
Shilajit	1	2
Sour Cherry	2	2
St. Johns Wort	1	2
Stevia	1	2
Suma (Pfaffia Paniculata)	1	2

[+]

Pubmed Data : J Ethnopharmacol. 2006 Dec 6;108(3):398-406. Epub 2006 Jun 2. PMID: 16824715

Article Published Date : Dec 06, 2006

Study Type : Human Study

Additional Links

Diseases : Lipopolysaccharide-Induced Toxicity, Rheumatoid Arthritis

Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

[+]

Chondroprotective properties of human-enriched serum following polyphenol extract absorption.Dec 15, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2019 Dec 16 ;11(12). Epub 2019 Dec 16. PMID: 31888255

Article Published Date : Dec 15, 2019

Study Type : Human Study

Additional Links

Substances : Grape, Olive leaf extract, Polyphenols

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts, Proanthocyanidins

[+]

[+]

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

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Pubmed Data : J Clin Psychopharmacol. 2015 Aug ;35(4):406-10. PMID: 26066335

Article Published Date : Jul 31, 2015

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Depression

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome

Problem Substances : Antidepressants

[+]

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Dietary vitamin D mitigates coronavirus-induced lung inflammation and damage.Dec 14, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Cureus. 2023 Jul ;15(7):e41377. Epub 2023 Jul 4. PMID: 37546047

Article Published Date : Jun 30, 2023

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Pubmed Data : J Biol Regul Homeost Agents. 2018 Mar 26 ;32(2). Epub 2018 Mar 26. PMID: 29577710

Article Published Date : Mar 25, 2018

Study Type : Human Study

Additional Links

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation

[+]

Click here to read the entire abstract

Pubmed Data : Eur J Nutr. 2017 Jul 10. Epub 2017 Jul 10. PMID: 28695324

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Pubmed Data : Complement Ther Clin Pract. 2021 May ;43:101383. Epub 2021 Apr 2. PMID: 33862350

Article Published Date : Apr 30, 2021

Study Type : Human Study

Additional Links

Substances : Pomegranate Peel

Diseases : Gingivitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation

Additional Keywords : Plant Extracts

[+]

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Biomedicines. 2021 Jul 22 ;9(8). Epub 2021 Jul 22. PMID: 34440065

Article Published Date : Jul 21, 2021

Study Type : Human Study

Additional Links

Diseases : Cardiovascular Diseases, Inflammation

Therapeutic Actions : Dietary Modification: Mediterranean Diet

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Risk Reduction

[+]

The benefits of multi-strain probiotics in enhancing BDNF, ameliorating inflammation and oxidative stress in Alzheimer's disease patients.Dec 19, 2023

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Pubmed Data : Nutrients. 2023 Dec 20 ;16(1). Epub 2023 Dec 20. PMID: 38201846

Article Published Date : Dec 19, 2023

Study Type : Human Study

Additional Links

Substances : Probiotics

Diseases : Alzheimer's Disease, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Brain-derived neurotrophic factor modulator, Interleukin-1 beta downregulation, Superoxide Dismutase Up-regulation

[+]

The clinical effect of a propolis and mangosteen extract complex in subjects with gingivitis.Sep 04, 2024

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Pubmed Data : Trop Biomed. 2019 Dec 1 ;36(4):1087-1098. PMID: 33597478

Article Published Date : Nov 30, 2019

Study Type : Human In Vitro

Additional Links

Substances : Medicinal Mushrooms

Diseases : Dengue

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Anti-tumor and immunoregulatory effects of fermented papaya preparation.Dec 31, 2015

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Anti-inflammatory activity of carvacrol protects the heart from lipopolysaccharide-induced cardiac dysfunction.Jun 30, 2023

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Pubmed Data : Life Sci. 2023 Jul 1 ;324:121743. Epub 2023 Apr 27. PMID: 37120013

Article Published Date : Jun 30, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Carvacrol

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cardioprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

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[+]

Farrerol ameliorates TNBS-induced colonic inflammation.Jul 12, 2018

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Pubmed Data : Int J Mol Sci. 2018 Jul 13 ;19(7). Epub 2018 Jul 13. PMID: 30011811

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Pubmed Data : Turk J Med Sci. 2018 Aug 16 ;48(4):892-900. Epub 2018 Aug 16. PMID: 30121057

Licorice extract isoliquiritigenin protects endothelial function in type 2 diabetic mice.Sep 18, 2024

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Pubmed Data : Nutrients. 2024 Sep 19 ;16(18). Epub 2024 Sep 19. PMID: 39339760

Article Published Date : Sep 18, 2024

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Licorice

Diseases : Diabetes Mellitus: Type 2, Endothelial Dysfunction, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Limonin inhibits IL-1 β-induced inflammation and catabolism in chondrocytes and ameliorates osteoarthritis.Dec 31, 2020

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Pubmed Data : Food Funct. 2020 Jul 1 ;11(7):6666-6679. Epub 2020 Jul 13. PMID: 32658237

Article Published Date : Jun 30, 2020

Study Type : Animal Study

Additional Links

Substances : Fig

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Polysaccharides

[+]

Ginsenoside Rb2 improves insulin resistance by inhibiting adipocyte pyroptosis.Nov 30, 2020

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Pubmed Data : Adipocyte. 2020 Dec ;9(1):302-312. PMID: 32580621

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Pubmed Data : IUBMB Life. 2020 Jul 25. Epub 2020 Jul 25. PMID: 32710811

Article Published Date : Jul 24, 2020

Study Type : Animal Study

Additional Links

Substances : Oleuropein

Diseases : Lipopolysaccharide-Induced Toxicity, Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Photobiomodulation associated with lipid nanoparticles and hyaluronic acid accelerate the healing of excisional wounds Sep 30, 2022

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Pubmed Data : J Biomater Appl. 2022 Oct ;37(4):668-682. Epub 2022 Jun 15. PMID: 35705485

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Pubmed Data : Pharmacol Res. 2017 Feb 4 ;119:137-148. Epub 2017 Feb 4. PMID: 28167239

Article Published Date : Feb 03, 2017

Study Type : Animal Study

Additional Links

Substances : Gingerol

Diseases : Ischemia

Pharmacological Actions : Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

6-Shogao land dried ginger could be a potential nutraceutical candidate for AMD or other age-related eye diseases.Sep 30, 2025

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Pubmed Data : J Nutr Biochem. 2025 Oct ;144:109980. Epub 2025 May 29. PMID: 40449688

Article Published Date : Sep 30, 2025

Study Type : Animal Study

Additional Links

Substances : 6-Shogaol, Ginger

Diseases : Aging, Inflammation, Macular Degeneration

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

6-shogaol abrogates Parkinson's disease in rotenone-induced rodents.Oct 08, 2024

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Pubmed Data : Korean J Physiol Pharmacol. 2018 Nov ;22(6):627-636. Epub 2018 Oct 25. PMID: 30402023

Article Published Date : Oct 31, 2018

Study Type : Animal Study

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Substances : 6-Shogaol

Diseases : Endometriosis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation

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6-Shogaol treatment produced beneficial effects for TBI-induced anxiety/depression-like behaviors.Jan 10, 2022

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Pubmed Data : Int Immunopharmacol. 2024 Dec 5 ;142(Pt A):112953. Epub 2024 Sep 2. PMID: 39226828

Article Published Date : Dec 04, 2024

Study Type : Animal Study

Additional Links

Substances : Curcumin, Triptolide

Diseases : Arthritis, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Immunomodulatory: Th17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Proliferative, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance Synergy

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A variety of orange by-products could be used as food supplements in the potential amelioration of inflammatory bowel diseases.Sep 18, 2018

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Pubmed Data : Food Funct. 2018 Sep 19 ;9(9):4888-4896. PMID: 30167607

Article Published Date : Sep 18, 2018

Study Type : Animal Study

Additional Links

Substances : Orange

Diseases : Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

A. princeps extract might be developed as therapeutic potential in the treatment of inflammasome-mediated inflammatory disorders, such as gouty arthritis.Dec 31, 2017

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Actinidia arguta extract attenuates inflammasome activation: Potential involvement in NLRP3 ubiquitination.Feb 28, 2018

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Pubmed Data : J Ethnopharmacol. 2018 Mar 1 ;213:159-165. Epub 2017 Nov 21. PMID: 29174375

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Pubmed Data : Am J Transl Res. 2019 ;11(12):7300-7309. Epub 2019 Dec 15. PMID: 31934279

Article Published Date : Dec 31, 2018

Study Type : Animal Study

Additional Links

Substances : Peony

Diseases : Asthma

Pharmacological Actions : Anti-Asthmatic Agents, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Albiflorin alleviates severe acute pancreatitis-associated liver injury.Feb 20, 2024

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Pubmed Data : Biochem Genet. 2024 Feb 21. Epub 2024 Feb 21. PMID: 38381358

Article Published Date : Feb 20, 2024

Study Type : Animal Study

Additional Links

Substances : Peony

Diseases : Pancreatitis

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Aloesin has the therapeutic potential for treating cutaneous wounds.May 14, 2017

Alpha-lipoic acid improved neurological outcome in experimental stroke.Jul 10, 2018

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Pubmed Data : Cell Physiol Biochem. 2018 Jul 11 ;48(1):42-53. Epub 2018 Jul 11. PMID: 29996116

Article Published Date : Jul 10, 2018

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Stroke: Ischemic

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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View the Evidence: 3133 Abstracts with Interleukin-1 beta downregulation Research

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Anti-inflammatory and antioxidant activity of ursolic acidDec 31, 2022

Icariin displays promise in slowing the progression of diabetic nephropathy.Jun 17, 2025

Pharmacological effects of berberine on models of ulcerative colitis.Dec 31, 2021

Resveratrol for inflammatory bowel disease in preclinical studies.Dec 31, 2023

The immunomodulatory effects of lactoferrin and its derived peptides on NF-κB signaling pathway.Jul 31, 2023

Efficacy and safety of sinomenine for diabetic kidney diseases.Dec 28, 2023

The present review provides the evidence of LLLT-dependent reduction of IL-1β, TNF-α, and MMP-13.Aug 23, 2020

Therapeutic effects of epigallocatechin-3-gallate for inflammatory bowel disease.May 31, 2024

Bovine lactoferrin suppresses inflammatory cytokine expression in endometrial stromal cells in chronic endometritis.Nov 30, 2022

Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients.Dec 31, 2022

Tolerogenic probiotics Lactobacillus delbrueckii and Lactobacillus rhamnosus promote anti-inflammatory profile.Feb 29, 2024

A novel nonsurgical therapy for peri-implantitis using focused pulsed electromagnetic field.Dec 31, 2022

A single 20 min session of yogic breathing practice could reduce the levels of key pro-inflammatory biomarkers in saliva.Aug 17, 2016

Acupuncture attenuates postoperative inflammation in patients after craniotomy.Feb 29, 2020

An anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects.Aug 31, 2013

Astaxanthin treatment decreases pro-inflammatory cytokines and improves reproductive outcomes in patients with polycystic ovary syndrome undergoing assisted reproductive technology.Jul 31, 2024

Berberine improves negative symptoms and cognitive function in patients with chronic schizophrenia.Apr 16, 2023

Bloodroot and echinacea offset exercise-associated effects of immune activity.Nov 01, 2009

Breastfeeding protects against illness-induced anorexia and is mediated partially by docosahexaenoic acid.Jan 01, 2008

Bromelain-loaded nanocomposites decrease inflammatory and cytotoxicity effects of gliadin on Caco-2 cells and peripheral blood mononuclear cells of celiac patients.Nov 30, 2023

Cashew may have anti-inflammatory activity in rheumatoid arthritis patients.Dec 06, 2006

Chondroprotective properties of human-enriched serum following polyphenol extract absorption.Dec 15, 2019

Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction.Jan 27, 2024

Combined light therapy shows promising results in patients with chronic meibomian gland dysfunction and dry eye disease, even in recalcitrant cases.Aug 31, 2022

Concurrent alteration in inflammatory biomarker gene expression and oxidative stress: how aerobic training and vitamin D improve T2DM.Jun 21, 2022

Curcumin could reverse the development of depression and enhance the outcome of antidepressants treatment in major depressive disorder.Jul 31, 2015

Curcumin supplementation improved glycemic control, reduced systemic inflammation and oxidative stress, and significantly improved hepatic steatosis and liver stiffness in patients with MASLD.Jun 09, 2025

Curcumin suppresses inflammation in the mucosa of children and adults with inflammatory bowel disease. Nov 02, 2009

Daily consumption of BC30 by adult’s aged 65-80 y can increase beneficial groups of bacteria in the human gut.Jun 30, 2015

Dietary inulin may improve obese PCOS women disease through the gut flora-inflammation-steroid hormone pathway.Aug 30, 2024

Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee osteoarthritis.Aug 27, 2017

Dietary vitamin D mitigates coronavirus-induced lung inflammation and damage.Dec 14, 2023

Effect of adjuvant probiotic therapy (Lactobacillus reuteri) in the treatment of periodontitis associated with diabetes mellitus.Jan 05, 2024

Effect of B vitamins supplementation on cardio-metabolic factors in patients with stable coronary artery disease.Dec 31, 2019

Effect of berberine on activation of TLR4-NFκB signaling pathway and NLRP3 inflammasome in patients with gout.Sep 19, 2022

Effect of maqui-berry extract in dry eye disease - A clinical and molecular analysis.Mar 31, 2023

Effect of Pleurotus ostreatus water extract consumption on blood parameters and cytokine values.Jun 26, 2024

Effect of the intravascular low energy laser illumination during percutaneous coronary intervention on the inflammatory process in vascular wall.Apr 30, 2013

Effect of the ketone beta-hydroxybutyrate on markers of inflammation and immune function in adults with type 2 diabetes.Mar 11, 2024

Effects of 14-weeks betaine supplementation on pro-inflammatory cytokines and hematology status in professional youth soccer players.Jun 04, 2021

Effects of Sudarshan Kriya yoga and advanced meditation program on benetic expression of pro-inflammatory and antioxidants genes.Jun 30, 2023

Electroacupuncture has a therapeutic effect on patients wtih osteoarthritis. Jul 01, 2009

Electroacupuncture inhibits the corneal ROS/TXNIP/NLRP3 signaling pathway in a rat model of dry eye syndrome.Sep 22, 2021

Etiological periodontal treatment with and without low-level laser therapy on IL-1β level.Mar 25, 2018

Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids.Nov 30, 2019

Green tea chewing gum may be a safe adjunct for treatment of gingival inflammation. May 31, 2016

Green tea supplementation, in addition to SRP, may reduce salivary IL-1β levels in patients with chronic periodontitis.Dec 31, 2021

High polyphenol intake may help individuals to reduce systemic inflammation.May 04, 2023

Higher flavonoid intake is associated with lower IL-1β.Jan 29, 2020

Histological improvement and cytokine levels reduction in patients with oral lichen llanus after photobiomodulation therapy.Oct 09, 2024

Honey reduce the probable aggravating effects of intensive cycling training on spermatogenesis and fertility capacity in road cyclists.Apr 30, 2012

Hyperbaric oxygen therapy reduces oxidative stress and inflammation, and increases growth factors favouring the healing process of diabetic wounds.Apr 10, 2023

Immunomodulating effect of the consumption of watercress on exercise-induced inflammation.Jul 29, 2021

Impact of Photobiomodulation on IL1β and TGFβ-1 concentrations in patients with aphthous stomatitis.Jul 07, 2024

Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis.Mar 26, 2023

Including almonds in diets as a snack may help healthy overweight and obese individuals improve nutritional status and reduce their risk for CVD.Jul 09, 2017

Influence of superpulsed laser therapy on healing processes following tooth extraction.Jul 31, 2011

Intake of bilberries has an ameliorating effect on some markers of gingival inflammation reducing gingivitis to a similar extent compared to standard of care.Dec 31, 2014

Intestinal homeostasis is a balance between pro and anti-inflammatory responses of intestinal immunocytes and could be maintained by probiotics.Dec 31, 2012

Irritable eye syndrome: neuroimmune mechanisms and benefits of selected nutrients.Mar 31, 2014

LLLT was effective in reducing the severity of chemoradiotherapy-induced OM.Mar 31, 2015

Local ice cryotherapy had beneficial effects in human non-septic knee arthritis.Jul 29, 2019

Low level light effects on inflammatory cytokine production by rheumatoid arthritis synoviocytes.Mar 31, 2009

Lutein exerts anti-inflammatory effects in patients with coronary artery disease.May 05, 2017

Micronized palmitoylethanolamide, hempseed oil, and maritime pine bark dry extract for pelvic pain.Feb 13, 2023

Moderate-intensity exercise may help maintain cellular functions.Oct 05, 2023

Montmorency cherries significantly lowered systemic inflammatory and oxidative stress induced by a series of metabolically challenging cycling bouts.Dec 31, 2013

Oligopin supplementation in traumatic brain injury patients in ICU reduced inflammation and improved the clinical status.Aug 31, 2021

Olive fruit and almond skin extract seems to protect LDL from oxidation and to prevent inflammatory status in moderately hypercholesterolemic subjects.Aug 17, 2020

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis. Jul 01, 2009

Omega-3 long chain-polyunsaturated fatty acids could have a potential therapeutic impact on chronic inflammation in Duchenne muscular dystrophy.Sep 22, 2017

Ozone therapy is a potential therapeutic alternative for Multiple sclerosis patients.Sep 14, 2017

Interleukin-1 beta downregulation

View the Evidence:
3133 Abstracts with Interleukin-1 beta downregulation Research