Interleukin-10 downregulation

Name	AC	CK
Quercetin	4	16
Silibinin	2	11
Bacillus Clausii	1	10
Chokeberry	1	10
Curcumin	6	10
Humic Acid	1	10
Lactobacillus paracasei	1	10
Paeoniflorin	5	10
Progesterone	1	10
Theanine	1	10
Bromelain	3	6
Ginger	3	6
Kefir	3	6
Turmeric	3	6
Flavonoids	3	5
Berberine	2	4
Gotu Kola	2	4
Grape Seed Extract	2	4
Hydrogen Water	2	4
Polyphenols	2	4
Ellagic Acid	1	3
Hesperidin	2	3
Lactobacillus plantarum	2	3
Lactobacillus rhamnosus	2	3
Alpha Linolenic Acid	1	2
Apigenin	1	2
Artichoke	1	2
Ashwagandha	1	2
Bee Propolis	1	2
Bergamot	1	2
Bitter Melon	1	2
Black Tea	1	2
Broccoli Sprouts	1	2
Burdock	1	2
Camel Milk	1	2
Cannabidiol	1	2
Cannabigerol	1	2
Cannabinoids	1	2
Cannabis	1	2
Chia	1	2
Chrysanthemum Indicum	1	2
Crocin	1	2
Diallyl sulfide	1	2
Eucalyptus	1	2
Ferulic acid	1	2
Flaxseed	1	2
Frankincense	1	2
Genistein	1	2
Ginsenosides	1	2
Green Tea	1	2
Hibiscus sabdariffa	1	2
Honokiol	1	2
Icariin	1	2
Indole-3-Carbinol	1	2
Isoliquiritigenin	1	2
Jujube	1	2
Kimchi	1	2
Lactobacillus probiotics	1	2
Lactobacillus reuteri	1	2
Lactobacillus rhamnosus GG	1	2
Loquat Leaves	1	2
Lycopene	1	2
Melatonin	1	2
Mussel: Green-lipped (Perna canaliculus)	1	2
Myrrh	1	2
Naringenin	1	2
Oridonin	1	2
Panax Notoginseng	1	2
Peony	1	2
Plantago	1	2
Plantago asiatica	1	2
Polyunsaturated Fatty Acids (PUFAs)	1	2
Pomegranate Peel	1	2
Propolis: Bee	1	2
Punicalagin	1	2
Pycnogenol (Pine Bark)	1	2
Red Sage	1	2
Rosemaric Acid	1	2
Soy	1	2
St. Johns Wort	1	2
Sulforaphane	1	2
Tangeretin	1	2
Tea	1	2
Thymoquinone	1	2
Verbascoside	1	2
Vinpocetine	1	2
Water: Deep Sea	1	2
Zerumbone	1	2
Antrodia camphorata	1	1
Astragaloside	1	1
Barberry	1	1
Beta-glucan	1	1
Celastrol	1	1
Cranberry Proanthocyanidins	1	1
Dandelion	1	1
EGCG (Epigallocatechin gallate)	1	1
Guava	1	1
Lactobacillus helveticus	1	1
Maqui	1	1
Moringa oleifera	1	1
Paeonol	1	1
Procyanidin B2	1	1
Reishi Mushroom	1	1
Resveratrol	1	1
Rose	1	1
Royal Jelly	1	1
Shikonin	1	1
Stilbenes	1	1
Sumac	1	1
Tanshinone IIA	1	1
Wogonin	1	1
Wormwood	1	1
Yoghurt	1	1

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Pubmed Data : Eur J Nutr. 2019 Mar 27. Epub 2019 Mar 27. PMID: 30919084

Article Published Date : Mar 26, 2019

Study Type : Animal Study

Additional Links

Substances : Bergamot, Flavonoids

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

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Alteration of adipose tissue immune cell milieu towards the suppression of inflammation in high fat diet fed mice by flaxseed oil supplementation.Dec 31, 2018

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Berberine reduces the occurrence of neonatal necrotizing enterocolitis by reducing the inflammatory response.Nov 30, 2018

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Pubmed Data : Exp Ther Med. 2018 Dec ;16(6):5280-5285. Epub 2018 Oct 17. PMID: 30542485

Article Published Date : Nov 30, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Enterocolitis: Necrotiziing

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Berberine was found to significantly reduce allergic inflammation in mice. Aug 14, 2015

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Pubmed Data : Rhinology. 2015 Aug 15. Epub 2015 Aug 15. PMID: 26275466

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Photoprotective

Additional Keywords : Plant Extracts

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Combined exercise training had positive effects on inflammatory and oxidative stress levels in a model of metabolic syndrome and menopause.Dec 14, 2015

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Pubmed Data : Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15 ;309(12):R1532-9. Epub 2015 Sep 30. PMID: 26423710

Article Published Date : Dec 14, 2015

Study Type : Animal Study

Additional Links

Diseases : Menopausal Syndrome, Metabolic Syndrome X, Oxidative Stress

Therapeutic Actions : Exercise

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Interleukin-10 downregulation, Renoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Concentrated deep sea water could be useful in preventing the development of atopic dermatitis.Jul 25, 2012

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Pubmed Data : Inflamm Bowel Dis. 2010 Dec;16(12):2012-21. PMID: 20848493

Article Published Date : Dec 01, 2010

Study Type : Animal Study

Additional Links

Substances : Bromelain

Diseases : Colitis, Colon Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation

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Effect of essential oils from ginger and turmeric rhizomes on some inflammatory biomarkers in cadmium induced neurotoxicity in rats.Dec 31, 2017

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Pubmed Data : J Toxicol. 2018 ;2018:4109491. Epub 2018 Oct 8. PMID: 30402094

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Ginger, Turmeric

Diseases : Cadmium Poisoning

Pharmacological Actions : Acetylcholinesterase Inhibitor, Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Essential Oils

Problem Substances : Cadmium

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Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in H22 tumor-bearing mice.Oct 31, 2019

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Pubmed Data : Neurosci Lett. 2002 Nov 29 ;333(3):167-70. PMID: 12429374

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Pubmed Data : Exp Gerontol. 2010 Dec;45(12):950-6. Epub 2010 Sep 9. PMID: 20817086

Article Published Date : Dec 01, 2010

Study Type : Animal Study

Additional Links

Substances : Melatonin

Diseases : Aging, Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Interleukin-10 downregulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction.Jan 17, 2017

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Pubmed Data : Int J Biol Macromol. 2017 Jan 18. Epub 2017 Jan 18. PMID: 28109806

Article Published Date : Jan 17, 2017

Study Type : Animal Study

Additional Links

Substances : Bitter Melon

Diseases : Myocardial Infarction

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cardioprotective, Hypolipidemic, Interleukin-10 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Polysaccharides

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Nephroprotective effect of essential oils from ginger and turmeric rhizomes against cadmium-induced nephrotoxicity.Dec 31, 2017

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Pubmed Data : J Oleo Sci. 2018 ;67(10):1339-1345. PMID: 30305562

Article Published Date : Dec 31, 2017

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Pubmed Data : Rejuvenation Res. 2010 Dec;13(6):665-74. Epub 2010 Sep 6. PMID: 20818935

Article Published Date : Dec 01, 2010

Study Type : Animal Study

Additional Links

Substances : Flavonoids, Green Tea, Polyphenols, Soy, Tea

Diseases : Aging, Aging: Immunosenecence, Lipid Peroxidation, Ovariectomy Associated Adverse Changes

Pharmacological Actions : Antioxidants, Interleukin-10 downregulation, Interleukin-6 Downregulation

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Statins exhibit complex immunomodulatory properties, including T cell-mediated tumour immune tolerance. Aug 01, 2010

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Pubmed Data : Clin Exp Immunol. 2010 Aug ;161(2):298-305. Epub 2010 May 18. PMID: 20491794

Article Published Date : Aug 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Immune Disorders: Low Immune Function, Tumors

Pharmacological Actions : Antiproliferative , Cell cycle arrest, Interleukin-10 downregulation

Problem Substances : Simvastatin

Adverse Pharmacological Actions : Immunosuppressive

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Sulforaphane exhibits antiproliferative, apoptotic, anti-inflammatory, and anti-angiogenic properties and ameliorates a rat model of endometriosis.Apr 01, 2019

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Pubmed Data : Dose Response. 2019 Apr-Jun;17(2):1559325819855538. Epub 2019 Jun 11. PMID: 31217757

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Pubmed Data : J Ethnopharmacol. 2018 Oct 28 ;225:178-188. Epub 2018 Jul 20. PMID: 30009976

Article Published Date : Oct 27, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Plantago, Verbascoside

Diseases : Wound Healing

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-12 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Z. jujuba root bark extracts could be a therapeutic agent for liver toxicity and chronic inflammation.Dec 31, 2015

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Anti-inflammatory secondary metabolites from the leaves of Rosa laevigata.May 31, 2013

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Pubmed Data : Bioorg Med Chem. 2013 Jun 1 ;21(11):3290-7. Epub 2013 Mar 24. PMID: 23632365

Article Published Date : May 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Rose

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

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Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.Dec 31, 2014

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Pubmed Data : Korean J Physiol Pharmacol. 2015 Jan ;19(1):21-7. Epub 2014 Dec 31. PMID: 25605993

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Neuroprotective effect of tanshinone IIA-incubated mesenchymal stem cells on Aβ25-35-induced neuroinflammation.Jun 02, 2019

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Pubmed Data : Behav Brain Res. 2019 Jun 3 ;365:48-55. Epub 2019 Mar 1. PMID: 30831140

View the Evidence: 135 Abstracts with Interleukin-10 downregulation Research

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Bacillus clausii exerts immuno-modulatory activity in allergic subjects.Mar 31, 2005

Consumption of chokeberry products modestly lowered blood pressure and reduced low-grade inflammation.Oct 31, 2016

Electroacupuncture at Lieque, Chize, and Zusanli can lessen the lung injury induced by severe acute pancreatitis.Dec 31, 2016

Electroacupuncture can effectively decrease the proinflammatory cytokine of IL-1 and IL-6 and increase the inhibition cytokine of IL-4 and IL-10 and improve the internal environment of occurrence and progression of rheumatoid arthritis.Oct 01, 2010

Far infrared radiation therapy provides an effective treatment modality for patients with chronic lymphedema.May 31, 2017

Low levels of progesterone in the follicular phase could be responsible for the progression of endometriosis and related pain. Mar 01, 2010

Oxihumante has immunstimulatory properties. Mar 01, 2003

Phototherapy appears to be a plausible complementary option to reduce the inflammatory component in rheumatoid arthritis.Oct 31, 2015

Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis.Jul 31, 2011

Serum oxidized low-density lipoprotein is inversely correlated to telomerase activity in peripheral blood mononuclear cells of haemodialysis patients..Dec 01, 2006

Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia.Apr 18, 2019

Supplementation with L-theanine seems to exert a beneficial effect on a disrupted Th1/Th2 balance in elite athletes.Feb 14, 2019

These data strongly suggest that probiotics may down modulate key parameters of allergic rhinitis.Mar 31, 2011

This study shows the feasibility of treating chronic HPV lesions with acupuncture.May 31, 2017

Ellagic acid protects type II collagen induced arthritis.Sep 30, 2022

Oridonin protects the lung against hyperoxia-induced injury in a mouse model.Dec 31, 2016

1,8-cineol appears to be able to augment protection against influenza viral infection in mice.Jul 31, 2016

A cocoa enriched diet produces an immunomodulatory effect that prevents anti-allergen IgE synthesis.May 31, 2012

A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer.Mar 26, 2019

Alteration of adipose tissue immune cell milieu towards the suppression of inflammation in high fat diet fed mice by flaxseed oil supplementation.Dec 31, 2018

An extract of St. Johns Wort has significant therapeutic efficacy for mice infected with influenza A virus.Jan 31, 2012

Anti-fibrotic actions of roselle extract in rat model of myocardial infarction.Aug 19, 2018

Antidepressant activity of ω-3 polyunsaturated fatty acids in ovariectomized rats: role of neuroinflammation and microglial polarization.Jan 07, 2020

Anti‑inflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide.Aug 31, 2014

Apigenin administration effectively ameliorated autoimmune myocarditis-induced cardiac hypertrophy and cardiac dysfunctionDec 10, 2015

Bee pollen and propolis protect against neuroinflammation in the rodent model of autism. Nov 15, 2019

Berberine reduces the occurrence of neonatal necrotizing enterocolitis by reducing the inflammatory response.Nov 30, 2018

Berberine was found to significantly reduce allergic inflammation in mice. Aug 14, 2015

Bromelain has immunomodulatory properties. Dec 20, 2006

Camel milk may be an interesting complementary approach for the management of inflammatory bowel diseases.Jun 30, 2014

Cannabichromene could be considered for clinical experimentation in inflammatory bowel disease patients.Apr 30, 2013

Cannabidiol could be used to prevent experimental colitis in mice.Oct 31, 2009

Centella asiatica may be useful in preventing liver damage.Oct 31, 2016

Chia intake presented low calcium bioavailability regardless of the type of diet consumed and was able to improve inflammation and the lipid profile.Dec 31, 2018

Chronic administration of the soluble, nonbacterial fraction of kefir attenuates lipid deposition.Feb 28, 2017

Chrysanthemum indicum was a novel photo-protective agent from natural resources against UV irradiation.Sep 30, 2015

Combined exercise training had positive effects on inflammatory and oxidative stress levels in a model of metabolic syndrome and menopause.Dec 14, 2015

Concentrated deep sea water could be useful in preventing the development of atopic dermatitis.Jul 25, 2012

Crocin administration may reduce inflammation-driven tissue damage in patients with hemorrhagic shock.Apr 27, 2017

Curcumin protects against hemorrhage/resuscitation injury. Feb 01, 2003

Curcumin protects against necrotizing enterocolitis in neonatal rats.Feb 01, 2010

Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts.Jul 01, 2010

Diallyl sulfide may be an effective supplement to alleviate asthma.Jan 12, 2016

Dietary gluten reduces the number of intestinal regulatory T cells in mice which may result in loss of self-tolerance and therefore increased risk of type 1 diabetes.Jun 01, 2008

Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in mice with colitis.Dec 01, 2010

Effect of essential oils from ginger and turmeric rhizomes on some inflammatory biomarkers in cadmium induced neurotoxicity in rats.Dec 31, 2017

Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in H22 tumor-bearing mice.Oct 31, 2019

Effects of three hydrogen-rich liquids on hemorrhagic shock in rats.Dec 31, 2014

Ferulic acid has ameliorative potential in mitigation of the painful states associated with vincristine-induced painful neuropathy.Dec 14, 2014

Formulations containing naringenin may be a promising approach to protecting the skin from the deleterious effects of UVB irradiation.Dec 31, 2015

Frankincense and Myrrh suppressed arthritic progression in rats more effective than single drug treatment. Dec 31, 2014

Genistein can be a potential natural agent against schistosomiasis.Feb 02, 2017

Ginger and turmeric rhizomes decreased the anti-inflammatory cytokines in hypertensive rats.Mar 21, 2016

Green mussel extract exhibits analgesic and anti-inflammatory properties in a rat adjuvant-induced arthritis model. Jun 01, 2009

GSE has protective roles on IBD through altering gut inflammation, tight junction protein expression, and gut microbiota composition.Nov 30, 2013

Honokiol can attenuate high cholesterol and high fat diet induced non-alcoholic steatohepatitis.Jul 01, 2017

Hydrogen rich water could exert a neuroprotective effect against traumatic brain injury and attenuate inflammation.Apr 14, 2016

Hyperbaric oxygen therapy may reverse oxidative stress and pro-inflammatory factors induced by radiation.Jan 31, 2017

Icariin alleviates Escherichia coli lipopolysaccharide-mediated endometritis.Sep 05, 2022

Inhibitory effect of Centella asiatica extract on DNCB-induced atopic dermatitis.Feb 04, 2020

Isoliquiritigenin attenuates spinal tuberculosis through inhibiting immune response.Jun 30, 2018

Kefir has the potential to benefit the management of MetS.Jul 06, 2016

Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats.Dec 13, 2015

Lactobacilli inhibits atopic dermatitis. May 01, 2011

Lactobacillus rhamnosus GG had beneficial effects in rotavirus-infected mice.Jul 02, 2017

Linagliptin and indole-3-carbinol combination might represent a beneficial therapeutic modality for amelioration of polycystic ovarian syndrome.Jul 31, 2017

Loquat leaf has anti-inflammatory effects in a rat model of chronic bronchitis. Jan 01, 2009

Lovastatin alters the immunological balance towards a Th2 dominant state.Nov 29, 2002

Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model.Dec 31, 2018

Malaysian propolis attenuates hepatic lesion in DM and exerts a synergistic protective effect with the anti-hyperglycemic medication, metformin.Oct 14, 2018

Melatonin improves inflammation processes in the liver of age-accelerated prone male mice.Dec 01, 2010

Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction.Jan 17, 2017

Interleukin-10 downregulation

View the Evidence:
135 Abstracts with Interleukin-10 downregulation Research