Interleukin-17 downregulation

Name	AC	CK
Curcumin	3	14
Alpha-Lipoic Acid	2	12
Oleuropein	2	12
Paeoniflorin	7	11
Crocin	1	10
Ligustrazine	3	6
Probiotics	3	5
Berberine	2	4
Hyperforin	2	4
Lactobacillus casei	2	4
Peony	2	4
Cannabidiol	2	3
Vitamin E	2	3
Achiote	1	2
Anthocyanins	1	2
Artesunate	1	2
Astragaloside	1	2
Astragalus	1	2
Barley	1	2
Beta-Caryophyllene	1	2
Black Raspberry	1	2
Bromelain	1	2
Carnosic Acid	1	2
Carnosine	1	2
Carvacrol	1	2
EGCG (Epigallocatechin gallate)	1	2
Evening Primrose Oil	1	2
Fermented Foods and Beverages	1	2
Ferulic acid	1	2
Flavonoids	1	2
Ginseng (Korean)	1	2
Ginsenosides	1	2
Glycyrrhizin	1	2
Gotu Kola	1	2
Grape	1	2
Hemp Seed	1	2
Lactobacillus fermentum	1	2
Lactobacillus rhamnosus	1	2
Lactobacillus salivarius	1	2
Lavender: Essential Oil	1	2
Mangosteen	1	2
Noni	1	2
Okra	1	2
Oridonin	1	2
Parthenolide	1	2
Patchouli	1	2
Perillaldehyde	1	2
Phloretin	1	2
Pomegranate	1	2
Propolis: Bee	1	2
Quercetin	1	2
Raspberry	1	2
Saffron	1	2
Selenium	1	2
Shikonin	2	2
St. Johns Wort	1	2
Sulforaphane	1	2
Sweet Potato: Purple	1	2
Tarragon	1	2
Tetrahydrocurcumin	1	2
Vanillin	1	2
Vitamin D	1	2
Zinc	1	2
Almond	1	1
Cannabinoids	1	1
Capparis spinosa (caper)	1	1
Cucurbitacin E	1	1
Green Tea	1	1
Lactobacillus plantarum	1	1
Lupine	1	1
Resveratrol	1	1
Vitexins	1	1

Substances : Vitamin D

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

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Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:692-699. Epub 2018 Dec 12. PMID: 30553196

Article Published Date : Jan 31, 2019

Study Type : Animal Study

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Substances : Glycyrrhizin

Diseases : Hepatitis: Lectin-Induced (concanavalin)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-6 Downregulation

Problem Substances : Concanavalin A

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Glycyrrhizin improves the pathogenesis of psoriasis.May 26, 2021

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Pubmed Data : Pharm Biol. 2018 Dec ;56(1):455-464. PMID: 31070537

Article Published Date : Nov 30, 2018

Study Type : Animal Study

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Substances : Mangosteen

Diseases : Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation, Interleukin-17 downregulation

Additional Keywords : Natural Substance/Drug Synergy

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Okra polysaccharides could act as an effective material to enhance immune response.Dec 31, 2017

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Pubmed Data : Adv Pharmacol Sci. 2018 ;2018:8505383. Epub 2018 Oct 9. PMID: 30402093

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Pubmed Data : Mediators Inflamm. 2017 ;2017:6567432. Epub 2017 Jan 17. PMID: 28194046

Article Published Date : Dec 31, 2016

Study Type : Animal Study

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Substances : Noni

Diseases : Colitis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

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Tocotrienol-rich fraction could serve as a gut health supplement for preventive measures for ulcerative colitis condition in patients.Dec 31, 2018

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Pubmed Data : Biometals. 2021 Jan 3. Epub 2021 Jan 3. PMID: 33392795

Article Published Date : Jan 02, 2021

Study Type : Animal Study

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Substances : Zinc

Diseases : Aging, Inflammation, Zinc Deficiency

Pharmacological Actions : Immunomodulatory, Interferon Gamma Reducer, Interleukin-17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Shikonin inhibits CEBPD downregulation in IL‑17‑treated HaCaT cells and in an imiquimod‑induced psoriasis model.Aug 31, 2020

Pubmed Data : Complement Ther Med. 2019 Apr ;43:148-153. Epub 2019 Jan 19. PMID: 30935522

Article Published Date : Mar 31, 2019

Study Type : Review

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Substances : Green Tea

Diseases : Inflammatory Bowel Diseases

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Immunomodulatory effects of Lactobacillus plantarum on inflammatory response induced by Klebsiella pneumoniae.Sep 02, 2019

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Pubmed Data : Infect Immun. 2019 Sep 3. Epub 2019 Sep 3. PMID: 31481408

Article Published Date : Sep 02, 2019

Study Type : In Vitro Study

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Substances : Lactobacillus plantarum

Diseases : Klebsiella Infections

Pharmacological Actions : Immunomodulatory, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-17 downregulation, Interleukin-23 Downregulation

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L-theanine alleviates IMQ-induced psoriasis like skin inflammation.Dec 31, 2020

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Problem Substances : Bisphenol A

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Saikosaponin A may be used as a therapeutic candidate for allergic rhinitis disease.Jan 04, 2020

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Pubmed Data : Chem Biol Interact. 2020 Jan 5 ;315:108874. Epub 2019 Oct 24. PMID: 31669322

Article Published Date : Jan 04, 2020

Study Type : In Vitro Study

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Substances : Saikosaponin

Diseases : Allergic Rhinitis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, STAT3 Inhibitor

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View the Evidence: 117 Abstracts with Interleukin-17 downregulation Research

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Electroacupuncture could effectively reduce the suffering and improve the quality of life of rheumatoid arthritis patients.Jul 31, 2019

Electroacupuncture for acute ischemic stroke and its effect on plasma levels of IL-17 and IL-10.Aug 11, 2022

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations.Jan 13, 2021

Lipoic acid down-regulates inflammation in multiple sclerosis patients.Jan 01, 2010

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

These results suggest the beneficial and therapeutic effects of crocin in multiple sclerosis.Oct 15, 2019

Transmucosal administration of microgranular curcumin leads to enhanced curcumin bioavailability.Nov 30, 2015

Vitamin D modulates systemic inflammation in patients with severe COVID-19.Aug 23, 2022

Lactobacillus casei could act as a potent nutraceutical modulator forosteoarthritis treatment by reducing pain, inflammatory responses, and articular cartilage degradation.Dec 16, 2010

3, 3'- diindolylmethane hinders IL-17A/IL-17RA interaction and mitigates imiquimod-induced psoriasis.Jul 31, 2022

A herbal mixture from propolis, pomegranate, and grape pomace endowed with anti-inflammatory activity in an in vivo rheumatoid arthritis model.May 10, 2020

Administering curcumin may alleviate cerebral inflammation resulting from intracerebral hemorrhage.Mar 25, 2016

Administration of Epigallocatechin-3-gallate resulted in a significant reduction in bone loss.Sep 06, 2015

Alantolactone suppresses proliferation and the inflammatory response in human HaCaT keratinocytes.Jun 24, 2021

Anti-inflammatory effect a specific Lactiplantibacillus plantarum in an Ovalbumin-induced asthma model.Jun 07, 2022

Anti-psoriatic effect of Lavandula angustifolia essential oil and its major components linalool and linalyl acetate.Jul 01, 2020

Artemisia dracunculus L. modulates the immune system in a multiple sclerosis mouse model.Oct 30, 2019

Artemisinin alleviates intestinal inflammation and metabolic disturbance in ulcerative colitis rats induced by DSS.Dec 31, 2021

Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions.Feb 29, 2016

Astragaloside IV stimulates hippocampal neurogenesis after stroke.Dec 31, 2019

Berberine as a promising natural compound for the treatment of periodontal disease.Oct 29, 2021

Berberine attenuates arthritis in adjuvant-induced arthritis.Feb 19, 2019

Berberine exerted a superior anti-arthritic effect and the mechanism maybe involve the balance between Treg and Th17 cells.Mar 05, 2017

Beta-Caryophyllene ameliorates the development of experimental autoimmune encephalomyelitis.Apr 28, 2017

Bixin attenuates experimental autoimmune encephalomyelitis. Dec 31, 2019

Black raspberries and protocatechuic acid mitigate DNFB-induced contact hypersensitivity.Jun 05, 2020

Bromelain has a therapeutic effect in established allergic airway disease.Aug 31, 2012

Cannabidiol was found to promote neuronal survival by inhibiting JNK and p38 MAP kinases.Nov 24, 2016

Capsaicin attenuates imiquimod-induced epidermal hyperplasia and cutaneous inflammation in a murine model of psoriasis.Aug 31, 2021

Chrysin reduces hypercholesterolemia-mediated atherosclerosis through modulating oxidative stress, microflora, and apoptosis in experimental rats.Jul 26, 2022

Curcumin ameloriates experimental autoimmune encephalomyelitis through inhibition of IL-17 production.May 01, 2009

Dietary red raspberries attenuate dextran sulfate sodium-induced acute colitis.Dec 31, 2017

Dietary selenium supplementation alleviates immune toxicity in the hearts of chickens with lead-added drinking water.May 31, 2019

Diosgenin could be a good candidate for new MS treatment strategies.Sep 30, 2021

Effect of astaxanthin on neuron damage, inflammatory factors expressions and oxidative stress in mice with subarachnoid hemorrhage.Dec 31, 2020

Effect of carnosine and α-lipoic acid on hepatocyte apoptosis and the cytokine profile in induced fatty liver disease.Dec 31, 2019

Effect of combination treatment with Lactobacillus rhamnosus and corticosteroid in reducing airway inflammation in a mouse asthma model.Apr 22, 2022

Effect of electroacupuncture on expression of IL-23/IL-17 axis and TLR4 in infarcted tissue in rats with myocardial infarction.Sep 11, 2021

Effects of Astragalus membranaceus on systemic lupus erythematosus in a mouse model of pregnancy.May 31, 2022

Effects of naringenin on experimentally induced rheumatoid arthritis. Sep 30, 2021

EGCG improved lung damage in P. aeruginosa infection by inhibiting the production.Dec 31, 2021

Enteral exposure to P histicola suppresses arthritis via mucosal regulation.Jan 11, 2016

Fermented barley extract alleviates atopic dermatitis like skin lesions in NC/Nga mice.Mar 22, 2009

Fermented milk appears to potentially play a role in decreasing the Th17 response.Aug 07, 2018

Ferulic acid altered IL-17A/IL-17RA interaction and protected against imiquimod-induced psoriasis-like skin injuryJun 30, 2019

Fucoxanthin prevents the ovalbumin-induced food allergic response by enhancing the intestinal epithelial barrier and regulating the intestinal flora.Aug 09, 2022

Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation.Jun 30, 2021

Ginsenoside F2 may be a novel therapeutic approach for treating skin inflammation.Sep 29, 2016

Glycyrrhizin alleviates Con A-induced hepatitis.Jan 31, 2019

Glycyrrhizin improves the pathogenesis of psoriasis.May 26, 2021

Hemp seed and evening primrose oils treatment can be used to ameliorate the demyelination of spinal cord.Mar 31, 2019

Hyperforin could promote functional recovery when delivered in the later phases of stroke recovery.Aug 31, 2016

Hyperforin could protect against acute cerebral ischemic injury.Dec 31, 2017

Inhibitory effect of Centella asiatica extract on DNCB-induced atopic dermatitis.Feb 04, 2020

KGC3P attenuates ovalbumin-induced airway inflammation through downregulation of p-PTEN in asthmatic mice.Apr 29, 2019

Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305 attenuate skin inflammation.Feb 26, 2018

Ligustrazine could alleviate the airway inflflammation in the neutrophilic asthma mice model.Apr 30, 2018

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.Nov 30, 2018

Okra polysaccharides could act as an effective material to enhance immune response.Dec 31, 2017

Oleuropein supplementation could be a promising protective agent against colitis-associated colorectal cancer.Sep 28, 2015

Oral administration of paeoniflorin attenuates allergic contact dermatitis.Mar 31, 2015

Oridonin ameliorates experimental autoimmune encephalomyelitis.May 31, 2020

Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway.Dec 31, 2013

Paeoniflorin ameliorates experimental autoimmune encephalomyelitis.Jan 05, 2017

Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis.Nov 30, 2013

Parthenolide modulates immune response in cells from C57BL/6 mice induced with experimental autoimmune encephalomyelitis.Apr 30, 2017

Patchouli alcohol: a natural sesquiterpene against both inflammation and intestinal barrier damage of ulcerative colitis. Jul 31, 2020

Perillaldehyde has a significant preventative and therapeutic effect on vaginal candidiasis.Dec 31, 2018

Phloretin could be a potent and effective antiarthritis agent.Dec 31, 2015

Purple-fleshed potato has the potential to aid in the amelioration of ulcerative colitis symptoms.Mar 07, 2021

Quercetin may be an alternative treatment for rheumatoid arthritis because it modulates the main pathogenic pathways.Mar 21, 2017

Rosemary derived carnosic acid is a promising natural compound for the treatment of rheumatoid arthritis.Jul 31, 2018

Interleukin-17 downregulation

View the Evidence:
117 Abstracts with Interleukin-17 downregulation Research