Interleukin-17 downregulation

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10 Substances Researched for Interleukin-17 downregulation
NameACCKFocus
Curcumin314Locked
Alpha-Lipoic Acid110Locked
Lactobacillus casei24Locked
Probiotics23Locked
EGCG (Epigallocatechin gallate)12Locked
Oleuropein12Locked
Sulforaphane12Locked
Vitamin D12Locked
Cucurbitacin E 11Locked
Resveratrol11Locked

View the Evidence:
77 Abstracts with Interleukin-17 downregulation Research

[+]

Electroacupuncture could effectively reduce the suffering and improve the quality of life of rheumatoid arthritis patients.Jul 31, 2019

Pubmed Data : J Tradit Chin Med. 2019 Aug ;39(4):582-586. PMID: 32186107
Article Published Date : Jul 31, 2019
Study Type : Human Study
Additional Links
Diseases : Rheumatoid Arthritis
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation
[+]

Lipoic acid down-regulates inflammation in multiple sclerosis patients.Jan 01, 2010

Pubmed Data : PLoS One. 2010;5(9). Epub 2010 Sep 28. PMID: 20927401
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Substances : Alpha-Lipoic Acid
Diseases : Brain Inflammation , Multiple Sclerosis
Pharmacological Actions : cAMP up-regulation, Interleukin-17 downregulation, Interleukin-6 Downregulation
[+]

These new data support a potential role of oleuropein in the treatment of ulcerative colitis.Apr 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Apr 15 ;9(4). Epub 2017 Apr 15. PMID: 28420140
Article Published Date : Apr 14, 2017
Study Type : Human Study
Additional Links
Substances : Oleuropein
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation
[+]

These results suggest the beneficial and therapeutic effects of crocin in multiple sclerosis.Oct 15, 2019

Pubmed Data : J Biochem Mol Toxicol. 2019 Oct 16:e22410. Epub 2019 Oct 16. PMID: 31617649
Article Published Date : Oct 15, 2019
Study Type : Human Study
Additional Links
Substances : Crocin
Diseases : Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Transmucosal administration of microgranular curcumin leads to enhanced curcumin bioavailability.Nov 30, 2015

Pubmed Data : Anticancer Res. 2015 Dec ;35(12):6411-8. PMID: 26637850
Article Published Date : Nov 30, 2015
Study Type : Human Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Interleukin-17 downregulation
Additional Keywords : Increased Bioavailability
[+]

Lactobacillus casei could act as a potent nutraceutical modulator forosteoarthritis treatment by reducing pain, inflammatory responses, and articular cartilage degradation.Dec 16, 2010

Pubmed Data : Life Sci. 2010 Dec 16. Epub 2010 Dec 16. PMID: 21167838
Article Published Date : Dec 16, 2010
Study Type : Animal Study
Additional Links
Substances : Lactobacillus casei
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-12 downregulation, Interleukin-17 downregulation, Interleukin-2 Downregulation, Matrix Metalloproteinases Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A herbal mixture from propolis, pomegranate, and grape pomace endowed with anti-inflammatory activity in an in vivo rheumatoid arthritis model.May 10, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 May 11 ;25(9). Epub 2020 May 11. PMID: 32403241
Article Published Date : May 10, 2020
Study Type : Animal Study
Additional Links
Substances : Grape, Pomegranate, Propolis: Bee
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation
[+]

Administering curcumin may alleviate cerebral inflammation resulting from intracerebral hemorrhage.Mar 25, 2016

Pubmed Data : Neurosci Lett. 2016 Mar 26 ;620:74-82. Epub 2016 Mar 26. PMID: 27026486
Article Published Date : Mar 25, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Brain Inflammation , Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation
[+]

Administration of Epigallocatechin-3-gallate resulted in a significant reduction in bone loss.Sep 06, 2015

Pubmed Data : Int Immunopharmacol. 2015 Sep 7. Epub 2015 Sep 7. PMID: 26359545
Article Published Date : Sep 06, 2015
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Gingivitis, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anti-psoriatic effect of Lavandula angustifolia essential oil and its major components linalool and linalyl acetate.Jul 01, 2020

Pubmed Data : J Ethnopharmacol. 2020 Jul 2:113127. Epub 2020 Jul 2. PMID: 32623016
Article Published Date : Jul 01, 2020
Study Type : Animal Study
Additional Links
Substances : Lavender: Essential Oil
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, NF-kappaB Inhibitor
[+]

Artemisia dracunculus L. modulates the immune system in a multiple sclerosis mouse model.Oct 30, 2019

Pubmed Data : Nutr Neurosci. 2019 Oct 31:1-7. Epub 2019 Oct 31. PMID: 31665978
Article Published Date : Oct 30, 2019
Study Type : Animal Study
Additional Links
Substances : Tarragon
Diseases : Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-17 downregulation, Interleukin-23 Downregulation
[+]

Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions.Feb 29, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int Immunopharmacol. 2016 Mar ;32:32-38. Epub 2016 Jan 16. PMID: 26784569
Article Published Date : Feb 29, 2016
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-2 Downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Astragaloside IV stimulates hippocampal neurogenesis after stroke.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:421. Epub 2020 Apr 3. PMID: 32317974
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Astragaloside
Diseases : Stroke
Pharmacological Actions : Interleukin-17 downregulation, Neurogenesis
[+]

Berberine attenuates arthritis in adjuvant-induced arthritis.Feb 19, 2019

Pubmed Data : Eur J Pharmacol. 2019 Feb 20. Epub 2019 Feb 20. PMID: 30796904
Article Published Date : Feb 19, 2019
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation, NF-kappaB Inhibitor
[+]

Berberine exerted a superior anti-arthritic effect and the mechanism maybe involve the balance between Treg and Th17 cells.Mar 05, 2017

Pubmed Data : Biomed Pharmacother. 2017 Mar 6 ;89:887-893. Epub 2017 Mar 6. PMID: 28282791
Article Published Date : Mar 05, 2017
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-17 downregulation, Interleukin-6 Downregulation
[+]

Beta-Caryophyllene ameliorates the development of experimental autoimmune encephalomyelitis.Apr 28, 2017

Pubmed Data : Biomed Pharmacother. 2017 Apr 29 ;91:257-264. Epub 2017 Apr 29. PMID: 28463791
Article Published Date : Apr 28, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Autoimmune Diseases, Encephalomyelitis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Black raspberries and protocatechuic acid mitigate DNFB-induced contact hypersensitivity.Jun 05, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Jun 6 ;12(6). Epub 2020 Jun 6. PMID: 32517233
Article Published Date : Jun 05, 2020
Study Type : Animal Study
Additional Links
Substances : Black Raspberry
Diseases : Hypersensitivity
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-12 downregulation, Interleukin-17 downregulation
[+]

Bromelain has a therapeutic effect in established allergic airway disease.Aug 31, 2012

Pubmed Data : Altern Ther Health Med. 2012 Sep-Oct;18(5):9-17. PMID: 22894886
Article Published Date : Aug 31, 2012
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Allergic Airway Diseases, Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-12 downregulation, Interleukin-17 downregulation, Interleukin-4 downregulation
[+]

Cannabidiol was found to promote neuronal survival by inhibiting JNK and p38 MAP kinases.Nov 24, 2016

Pubmed Data : Fitoterapia. 2016 Nov 25 ;116:77-84. Epub 2016 Nov 25. PMID: 27890794
Article Published Date : Nov 24, 2016
Study Type : Animal Study
Additional Links
Substances : Cannabidiol
Diseases : Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation, Neuroprotective Agents
[+]

Curcumin ameloriates experimental autoimmune encephalomyelitis through inhibition of IL-17 production.May 01, 2009

Pubmed Data : Int Immunopharmacol. 2009 May;9(5):575-81. Epub 2009 Feb 3. PMID: 19539560
Article Published Date : May 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Multiple Sclerosis
Pharmacological Actions : Antiproliferative , Interleukin-17 downregulation, Interleukin-21 downregulation, Interleukin-6 Downregulation
[+]

Dietary red raspberries attenuate dextran sulfate sodium-induced acute colitis.Dec 31, 2017

Pubmed Data : J Nutr Biochem. 2018 01 ;51:40-46. Epub 2017 Sep 14. PMID: 29091813
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Raspberry
Diseases : Colitis, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Dietary selenium supplementation alleviates immune toxicity in the hearts of chickens with lead-added drinking water.May 31, 2019

Pubmed Data : Avian Pathol. 2019 Jun ;48(3):230-237. Epub 2019 Feb 18. PMID: 30663336
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Selenium
Diseases : Lead Poisoning
Pharmacological Actions : Cardioprotective, Immunomodulatory, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-2 Downregulation, Interleukin-4 downregulation, Interleukin-6 Downregulation
Problem Substances : Lead
[+]

Enteral exposure to P histicola suppresses arthritis via mucosal regulation.Jan 11, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arthritis Rheumatol. 2016 12 ;68(12):2878-2888. PMID: 27337150
Article Published Date : Jan 11, 2016
Study Type : Transgenic Animal Study
Additional Links
Substances : Probiotics
Diseases : Arthritis, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-17 downregulation
[+]

Fermented barley extract alleviates atopic dermatitis like skin lesions in NC/Nga mice.Mar 22, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biosci Biotechnol Biochem. 2009 Mar 23 ;73(3):489-93. Epub 2009 Mar 7. PMID: 19270394
Article Published Date : Mar 22, 2009
Study Type : Animal Study
Additional Links
Substances : Barley, Fermented Foods and Beverages
Diseases : Atopic Dermatitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation
Additional Keywords : Plant Extracts
[+]

Fermented milk appears to potentially play a role in decreasing the Th17 response.Aug 07, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2018 Aug 8 ;10(8). Epub 2018 Aug 8. PMID: 30096797
Article Published Date : Aug 07, 2018
Study Type : Animal Study
Additional Links
Substances : Lactobacillus fermentum
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation
[+]

Ferulic acid altered IL-17A/IL-17RA interaction and protected against imiquimod-induced psoriasis-like skin injuryJun 30, 2019

Pubmed Data : Food Chem Toxicol. 2019 Jul ;129:365-375. Epub 2019 May 3. PMID: 31054998
Article Published Date : Jun 30, 2019
Study Type : Animal Study
Additional Links
Substances : Ferulic acid
Diseases : Psoriasis
Pharmacological Actions : Interleukin-17 downregulation
Additional Keywords : Gene Expression Regulation
[+]

Ginsenoside F2 may be a novel therapeutic approach for treating skin inflammation.Sep 29, 2016

Pubmed Data : Biochem Biophys Res Commun. 2016 Sep 30 ;478(4):1713-9. Epub 2016 Sep 3. PMID: 27596969
Article Published Date : Sep 29, 2016
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Dermatitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-17 downregulation
[+]

Glycyrrhizin alleviates Con A-induced hepatitis.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Feb ;110:692-699. Epub 2018 Dec 12. PMID: 30553196
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Glycyrrhizin
Diseases : Hepatitis: Lectin-Induced (concanavalin)
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-6 Downregulation
Problem Substances : Concanavalin A
[+]

Hemp seed and evening primrose oils treatment can be used to ameliorate the demyelination of spinal cord.Mar 31, 2019

Pubmed Data : Res Pharm Sci. 2019 Apr ;14(2):146-154. Epub 2019 Mar 8. PMID: 31620191
Article Published Date : Mar 31, 2019
Study Type : Animal Study
Additional Links
Substances : Evening Primrose Oil, Hemp Seed
Diseases : Encephalomyelitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, STAT3 Inhibitor
[+]

Hyperforin could promote functional recovery when delivered in the later phases of stroke recovery.Aug 31, 2016

Pubmed Data : Brain Res. 2016 Sep 1 ;1646:504-13. Epub 2016 Jun 17. PMID: 27328426
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Hyperforin, St. Johns Wort
Diseases : Stroke: Attenuation/Recovery
Pharmacological Actions : Interleukin-17 downregulation, Neuroprotective Agents
[+]

Hyperforin could protect against acute cerebral ischemic injury.Dec 31, 2017

Pubmed Data : Brain Res. 2018 Jan 1 ;1678:254-261. Epub 2017 Sep 1. PMID: 28870826
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Hyperforin
Diseases : Cerebral Ischemia
Pharmacological Actions : Interleukin-17 downregulation, Neuroprotective Agents
[+]

Inhibitory effect of Centella asiatica extract on DNCB-induced atopic dermatitis.Feb 04, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2020 Feb 5 ;12(2). Epub 2020 Feb 5. PMID: 32033291
Article Published Date : Feb 04, 2020
Study Type : Animal Study
Additional Links
Substances : Gotu Kola
Diseases : Atopic Dermatitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, Interleukin-17 downregulation, Interleukin-4 downregulation, Interleukin-5 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

KGC3P attenuates ovalbumin-induced airway inflammation through downregulation of p-PTEN in asthmatic mice.Apr 29, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2019 Apr 30 ;62:152942. Epub 2019 Apr 30. PMID: 31102886
Article Published Date : Apr 29, 2019
Study Type : Animal Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-17 downregulation, Interleukin-4 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305 attenuate skin inflammation.Feb 26, 2018

Pubmed Data : Benef Microbes. 2018 Feb 27 ;9(2):299-309. Epub 2018 Feb 7. PMID: 29409331
Article Published Date : Feb 26, 2018
Study Type : Animal Study
Additional Links
Substances : Lactobacillus rhamnosus , Lactobacillus salivarius
Diseases : Atopic Dermatitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-22 Downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ligustrazine could alleviate the airway inflflammation in the neutrophilic asthma mice model.Apr 30, 2018

Pubmed Data : Chin J Integr Med. 2018 May ;24(5):353-358. Epub 2017 Oct 30. PMID: 29086220
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-17 downregulation
[+]

Mangosteen ethanol extract alleviated the severity of collagen-induced arthritis in rats and produced synergistic effects with methotrexate.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2018 Dec ;56(1):455-464. PMID: 31070537
Article Published Date : Nov 30, 2018
Study Type : Animal Study
Additional Links
Substances : Mangosteen
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-10 upregulation, Interleukin-17 downregulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Okra polysaccharides could act as an effective material to enhance immune response.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Adv Pharmacol Sci. 2018 ;2018:8505383. Epub 2018 Oct 9. PMID: 30402093
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Okra
Diseases : Staphylococcus aureus infection
Pharmacological Actions : Immunostimulatory, Interleukin-17 downregulation
Additional Keywords : Polysaccharides
[+]

Oleuropein supplementation could be a promising protective agent against colitis-associated colorectal cancer.Sep 28, 2015

Pubmed Data : Mol Nutr Food Res. 2015 Sep 29. Epub 2015 Sep 29. PMID: 26502315
Article Published Date : Sep 28, 2015
Study Type : Animal Study
Additional Links
Substances : Oleuropein
Diseases : Colitis, Colorectal Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Wnt/β-catenin pathway down-regulation
[+]

Oral administration of paeoniflorin attenuates allergic contact dermatitis.Mar 31, 2015

Pubmed Data : Int Immunopharmacol. 2015 Apr ;25(2):432-9. Epub 2015 Mar 3. PMID: 25744601
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Dermatitis
Pharmacological Actions : Interferon Gamma Reducer, Interleukin-10 downregulation, Interleukin-17 downregulation
[+]

Oridonin ameliorates experimental autoimmune encephalomyelitis.May 31, 2020

Pubmed Data : Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2020 Jun ;36(6):492-498. PMID: 32696738
Article Published Date : May 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Encephalomyelitis
Pharmacological Actions : Immunomodulatory, Interferon Gamma Reducer, Interleukin-17 downregulation
[+]

Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2014 Jan 1 ;306(1):G27-36. Epub 2013 Nov 14. PMID: 24232001
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Colitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeoniflorin ameliorates experimental autoimmune encephalomyelitis.Jan 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 02 6 ;7:41887. Epub 2017 Feb 6. PMID: 28165507
Article Published Date : Jan 05, 2017
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Multiple Sclerosis
Pharmacological Actions : Interleukin-17 downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor
[+]

Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis.Nov 30, 2013

Pubmed Data : Inflamm Res. 2013 Dec ;62(12):1035-44. Epub 2013 Oct 5. PMID: 24096935
Article Published Date : Nov 30, 2013
Study Type : Animal Study
Additional Links
Substances : Paeoniflorin
Diseases : Dermatitis: Contact
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-17 downregulation, Interleukin-2 Downregulation, Interleukin-4 upregulation
[+]

Parthenolide modulates immune response in cells from C57BL/6 mice induced with experimental autoimmune encephalomyelitis.Apr 30, 2017

Pubmed Data : Planta Med. 2017 May ;83(8):693-700. Epub 2016 Dec 20. PMID: 27997959
Article Published Date : Apr 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Multiple Sclerosis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Patchouli alcohol: a natural sesquiterpene against both inflammation and intestinal barrier damage of ulcerative colitis. Jul 31, 2020

Pubmed Data : Inflammation. 2020 Aug ;43(4):1423-1435. PMID: 32388657
Article Published Date : Jul 31, 2020
Study Type : Animal Study
Additional Links
Substances : Patchouli
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Perillaldehyde has a significant preventative and therapeutic effect on vaginal candidiasis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2019 ;10:1466. Epub 2019 Jul 2. PMID: 31333606
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Perillaldehyde
Diseases : Candidiasis: Vulvovaginal
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-22 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Phloretin could be a potent and effective antiarthritis agent.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2016 ;2016:9831263. Epub 2016 Dec 4. PMID: 28044086
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Phloretin
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Quercetin may be an alternative treatment for rheumatoid arthritis because it modulates the main pathogenic pathways.Mar 21, 2017

Pubmed Data : Biomed Pharmacother. 2017 Mar 22 ;90:38-46. Epub 2017 Mar 22. PMID: 28342364
Article Published Date : Mar 21, 2017
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Superiority of Natural Substances versus Drugs
[+]

Rosemary derived carnosic acid is a promising natural compound for the treatment of rheumatoid arthritis.Jul 31, 2018

Pubmed Data : J Cell Physiol. 2018 Aug ;233(8):6291-6303. Epub 2018 Mar 9. PMID: 29521424
Article Published Date : Jul 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Arthritis, Neuropathic Pain
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Matrix metalloproteinase-3 (MMP-3) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Study on the physicochemical properties and anti-inflammatory effects of paeonol in rats with TNBS-induced ulcerative colitis.Dec 31, 2016

Pubmed Data : Int Immunopharmacol. 2017 Jan ;42:32-38. Epub 2016 Nov 15. PMID: 27863299
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Peony
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-6 Downregulation
[+]

Sulforaphane may have therapeutic value in the treatment of rheumatoid arthritis.Jan 01, 2010

Pubmed Data : Arthritis Rheum. 2010 Jan;62(1):159-70. PMID: 20039434
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Interleukin-17 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Tetramethylpyrazine ameliorates experimental autoimmune encephalomyelitis by modulating the inflammatory response.Jul 31, 2018

Pubmed Data : Biochem Biophys Res Commun. 2018 Aug 1. Epub 2018 Aug 1. PMID: 30078676
Article Published Date : Jul 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Multiple Sclerosis
Pharmacological Actions : Interleukin-10 upregulation, Interleukin-17 downregulation, Interleukin-18 down-regulation
[+]

The administration of probiotic L. casei exerted an anti-inflammatory response in mice fed an high fat diet.Jun 30, 2015

Pubmed Data : Nutrition. 2015 Jul-Aug;31(7-8):1000-7. Epub 2015 Feb 24. PMID: 26059375
Article Published Date : Jun 30, 2015
Study Type : Animal Study
Additional Links
Substances : Lactobacillus casei, Probiotics
Diseases : High Fat Diet, Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Cytokine Modulation
[+]

The combination of Astragalus membranaceus extract and ligustrazine to improve the inflammation in rats with thrombolytic cerebral ischemia.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419869055. PMID: 31409163
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Astragalus, Ligustrazine
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Neuroprotective Agents
[+]

The hydroalcoholic extract of saffron can be considered as a useful strategy in the treatment of type 1 diabetes.Jan 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Allergy Asthma Immunol. 2019 Feb ;18(1):38-47. PMID: 30848572
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Saffron
Diseases : Diabetes Mellitus: Type 1
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-17 downregulation
[+]

The protective effects of 18 β-glycyrrhetinic acid on imiquimod-induced psoriasis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Immunol Res. 2020 ;2020:1980456. Epub 2020 Aug 27. PMID: 32908937
Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-23 Downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The study provides scientific reference for artesunate usage in preventing autoimmune liver injury.Apr 30, 2018

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 May ;43(10):2123-2128. PMID: 29933681
Article Published Date : Apr 30, 2018
Study Type : Animal Study
Additional Links
Substances : Artesunate
Diseases : Autoimmune Diseases, Chemically-Induced Liver Damage, Liver Damage
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interferon Gamma Reducer, Interleukin-17 downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Concanavalin A
[+]

These results may point to noni fruit as an important source of anti-inflammatory molecules.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2017 ;2017:6567432. Epub 2017 Jan 17. PMID: 28194046
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Noni
Diseases : Colitis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Tocotrienol-rich fraction could serve as a gut health supplement for preventive measures for ulcerative colitis condition in patients.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2019 ;65(4):318-327. PMID: 31474681
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Total glycosides of peony protects against inflammatory bowel disease.Dec 31, 2018

Pubmed Data : Am J Chin Med. 2019 ;47(1):177-201. Epub 2019 Jan 7. PMID: 30612460
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Peony
Diseases : Colitis, Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-23 Downregulation
Additional Keywords : Phytotherapy
[+]

Vanillin was an effective bioactive compound against psoriatic skin inflammation.Nov 28, 2017

Pubmed Data : J Agric Food Chem. 2017 Nov 29 ;65(47):10233-10242. Epub 2017 Nov 14. PMID: 29073354
Article Published Date : Nov 28, 2017
Study Type : Animal Study
Additional Links
Substances : Vanillin
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-23 Downregulation
[+]

Vitamin D3 supplementation diminished the inflammatory conditions in systemic lupus erythematosus.Mar 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Basic Med Sci. 2016 Apr ;19(4):374-80. PMID: 27279980
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Vitamin D
Diseases : Systemic Lupus Erythematosus
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation
[+]

Shikonin inhibits CEBPD downregulation in IL‑17‑treated HaCaT cells and in an imiquimod‑induced psoriasis model.Aug 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2020 Sep ;22(3):2263-2272. Epub 2020 Jul 9. PMID: 32705251
Article Published Date : Aug 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Psoriasis
Pharmacological Actions : Antiproliferative , Interleukin-17 downregulation
[+]

A novel probiotic mixture, slows down the tumor growth significantly and reduces the tumor size and weight by 40% compared with the control.Feb 15, 2016

Pubmed Data : Proc Natl Acad Sci U S A. 2016 Feb 16. Epub 2016 Feb 16. PMID: 26884164
Article Published Date : Feb 15, 2016
Study Type : In Vitro Study
Additional Links
Substances : Probiotics
Diseases : Gastrointestinal Inflammation, Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Immunomodulatory, Immunomodulatory: Th17 downregulation, Interleukin-17 downregulation
Additional Keywords : Microbiota
[+]

Cannabinoids could be possible agents for treatment of psoriasis. Jan 31, 2017

Pubmed Data : Med Hypotheses. 2017 Feb ;99:15-18. Epub 2016 Dec 14. PMID: 28110689
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cannabinoids
Diseases : Psoriasis
Pharmacological Actions : Angiogenesis Inhibitors, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Interleukin-17 downregulation, Interleukin-8 downregulation, Vascular Endothelial Growth Factor Inhibitors
[+]

Capparis Spinosa L. promotes anti-inflammatory responses in vitro.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Immunol. 2016 ;17(1):26. Epub 2016 Aug 2. PMID: 27483999
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Capparis spinosa (caper)
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-4 upregulation
[+]

CBD treatment may ameliorate experimental autoimmune encephalomyelitis through induction of immunosuppressive myeloid-derived suppressor cells.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Immunol. 2018 ;9:1782. Epub 2018 Aug 3. PMID: 30123217
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Cannabidiol
Diseases : Multiple Sclerosis
Pharmacological Actions : Immunosuppressive Agents, Interferon Gamma Reducer, Interleukin-17 downregulation
[+]

Green tea could reduce inflammatory and oxidant patterns in Inflammatory bowel diseases.Mar 31, 2019

Pubmed Data : Complement Ther Med. 2019 Apr ;43:148-153. Epub 2019 Jan 19. PMID: 30935522
Article Published Date : Mar 31, 2019
Study Type : Review
Additional Links
Substances : Green Tea
Diseases : Inflammatory Bowel Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Immunomodulatory effects of Lactobacillus plantarum on inflammatory response induced by Klebsiella pneumoniae.Sep 02, 2019

Pubmed Data : Infect Immun. 2019 Sep 3. Epub 2019 Sep 3. PMID: 31481408
Article Published Date : Sep 02, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus plantarum
Diseases : Klebsiella Infections
Pharmacological Actions : Immunomodulatory, Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-17 downregulation, Interleukin-23 Downregulation
[+]

Narrow-leafed lupin seeds gamma-conglutin is an anti-inflammatory protein promoting insulin resistance improvement and oxidative stress.Dec 22, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Dec 23 ;9(1). Epub 2019 Dec 23. PMID: 31877933
Article Published Date : Dec 22, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lupine
Diseases : Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-12 downregulation, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeoniflorin attenuates allergic inflammation in asthma.Dec 31, 2014

Pubmed Data : Int Immunopharmacol. 2015 Jan ;24(1):88-94. Epub 2014 Nov 26. PMID: 25433342
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-17 downregulation, Interleukin-5 downregulation
[+]

Paeoniflorin suppresses inflammatory response in imiquimod-induced psoriasis.Jul 31, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 Aug ;94(8):888-94. Epub 2016 Mar 10. PMID: 27348512
Article Published Date : Jul 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Psoriasis
Pharmacological Actions : Anti-Inflammatory Agents, Interferon Gamma Reducer, Interleukin-17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Paeoniflorin-6'-o-benzene sulfonate (CP-25) improves vasculitis.Oct 01, 2020

Pubmed Data : Phytother Res. 2020 Oct 2. Epub 2020 Oct 2. PMID: 33006176
Article Published Date : Oct 01, 2020
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Rheumatoid Arthritis, Vasculitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, STAT3 Inhibitor
[+]

Resveratrol prevents bisphenol A-induced autism, type 2 diabetes mellitus and metabolic syndrome.Jan 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrition. 2016 Feb ;32(2):174-8. Epub 2015 Sep 25. PMID: 26706021
Article Published Date : Jan 31, 2016
Study Type : Review
Additional Links
Substances : Resveratrol
Diseases : Autism Spectrum Disorders, Bisphenol-A Toxicity, Diabetes Mellitus: Type 2: Prevention, Metabolic Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Interleukin-17 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Microbiota, Risk Reduction
Problem Substances : Bisphenol A
[+]

Shikonin has anti-inflammatory effects on collagen-induced arthritis.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:2428546. Epub 2018 Dec 16. PMID: 30643526
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Shikonin
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation
[+]

These results imply that cucurbitacin E possesses powerful anti-encephalitogenic activity.Jun 21, 2016

Pubmed Data : J Agric Food Chem. 2016 Jun 22 ;64(24):4900-7. Epub 2016 Jun 8. PMID: 27225664
Article Published Date : Jun 21, 2016
Study Type : In Vitro Study
Additional Links
Substances : Cucurbitacin E
Diseases : Autoimmune Diseases, Encephalitis
Pharmacological Actions : Antioxidants, Interferon Gamma Reducer, Interleukin-17 downregulation, MicroRNA modulator, Nitric Oxide Inhibitor
[+]

These results may explain the antiviral potential of almond skins.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2015 ;20(5):8816-22. Epub 2015 May 15. PMID: 25988612
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Almond
Diseases : Herpes Simplex Virus Type 2
Pharmacological Actions : Antiviral Agents, Interleukin-17 downregulation
Additional Keywords : Plant Extracts

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