Interleukin-18 down-regulation

Name	AC	CK
Flavonoids	12	21
Ginsenosides	10	18
Berberine	4	14
Cherry: All Varieties	1	10
Cherry: Bing	1	10
Astragaloside	5	8
Emodin	4	7
Apigenin	3	6
Isoflavones	4	6
Mangiferin	4	6
Curcumin	3	5
EGCG (Epigallocatechin gallate)	3	5
Ginkgo biloba	3	5
Resveratrol	3	5
Biochanin A	2	4
Celastrol	2	4
Fucoidan	2	4
Gastrodin	2	4
Gingerol	2	4
Lutein	2	4
Paeoniflorin	2	4
Procyanidin B2	2	4
Punicalagin	2	4
Quercetin	2	4
Tanshinone IIA	2	4
Thymoquinone	2	4
Ursolic Acid	2	4
Billygoat Weed	1	3
Carvacrol	1	3
Glycyrrhizin	1	3
Panax Notoginseng	2	3
Safflower	2	3
6-Shogaol	1	2
Acai	1	2
Agrimony	1	2
Arctigenin	1	2
Artesunate	1	2
Beta Sitosterol	1	2
Betulinic acid	1	2
Broccoli	1	2
Cabbage	1	2
Catechin	1	2
Cinnamaldehyde	1	2
Crocin	1	2
Cyanidin 3-glucoside	1	2
Galactooligosaccharides	1	2
Geraniol	1	2
Goji	1	2
Green Tea	1	2
Gynostemma	1	2
Honokiol	1	2
Hydrogen: Molecular	1	2
Isoliquiritigenin	1	2
Kaempferol	1	2
Ligustrazine	1	2
Modified Arabinoxylan Rice Bran (MGN-3)	1	2
Mulberry	1	2
Naringenin	1	2
Paeonol	1	2
Patchouli	1	2
Persimmon	1	2
Piceatannol	1	2
Polyphenols	1	2
Pomegranate	1	2
Poria cocos	1	2
Prunella vulgaris	1	2
Puerarin	1	2
Raspberry	1	2
Reishi Mushroom	1	2
Rosemaric Acid	1	2
Stigmasterol	1	2
Sulforaphane	1	2
Tangeretin	1	2
Theaflavins	1	2
Verbascoside	1	2
acetyl-11-keto-beta-boswellic acid	1	2
Allicin	1	1
Alpha-Lipoic Acid	1	1
Asiatic Acid	1	1
Citrus naringin	1	1
Coriolus versicolor	1	1
Cucurbitacin B	1	1
Dogwood	1	1
Egg	1	1
Garlic	1	1
Lactobacillus plantarum	1	1
Licorice	1	1
Lotus	1	1
Luteolin	1	1
Nobiletin	1	1
Olive	1	1
Oridonin	1	1
Parthenolide	1	1
Perilla	1	1
Saikosaponin	1	1
Salvia miltiorrhiza	1	1
Sinomenine	1	1
Urolithin A	1	1
Vitamin C	1	1
Vitamin D	1	1
Vitamin E: Gamma-tocotrienol	1	1
Walnut	1	1
Watercress	1	1

Therapeutic Actions : Exercise: Cycling

Pharmacological Actions : Antidepressive Agents, Interleukin-18 down-regulation, Interleukin-6 Downregulation

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Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans.Feb 28, 2013

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Pubmed Data : J Nutr. 2013 Mar ;143(3):340-4. Epub 2013 Jan 23. PMID: 23343675

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Pubmed Data : Drug Des Devel Ther. 2022 ;16:3353-3364. Epub 2022 Sep 28. PMID: 36196145

Article Published Date : Dec 31, 2021

Study Type : Animal Study

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Substances : Flavonoids

Diseases : Kidney Damage

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Malondialdehyde Down-regulation, Renoprotective, Superoxide Dismutase Up-regulation

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Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice.Oct 31, 2020

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Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons.Jan 11, 2019

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Pubmed Data : Behav Pharmacol. 2019 12 ;30(8):700-711. PMID: 31703032

Article Published Date : Jan 11, 2019

Study Type : Animal Study

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Substances : Biochanin A

Diseases : Brain Inflammation , Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Cabbage extracts have a pancreato-protective effect.Jan 19, 2017

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Pubmed Data : Nat Prod Res. 2017 Jan 20:1-4. Epub 2017 Jan 20. PMID: 28107794

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Pubmed Data : ACS Omega. 2020 May 19 ;5(19):10878-10890. Epub 2020 May 5. PMID: 32455208

Article Published Date : May 18, 2020

Study Type : Animal Study

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Substances : Ginsenosides

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interleukin-18 down-regulation, Interleukin-6 Downregulation, Interleukin-8 downregulation

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Ginsenoside Rg1 may have protective effects on neuroinflammation and neuronal injury induced by chronic glucocorticoids exposure.Sep 30, 2017

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Pubmed Data : Behav Pharmacol. 2017 Apr 13. Epub 2017 Apr 13. PMID: 28410265

Article Published Date : Apr 12, 2017

Study Type : Animal Study

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Substances : Mangiferin

Diseases : Depression

Pharmacological Actions : Anti-Inflammatory Agents, Antidepressive Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

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Quercetin protects cadmium-induced renal injuries in mice by inhibiting cell pyroptosis.Dec 31, 2022

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Pubmed Data : Front Vet Sci. 2023 ;10:1319857. Epub 2023 Nov 16. PMID: 38033639

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Tangeretin attenuates acute lung injury in septic mice.Dec 31, 2023

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Pubmed Data : Inflamm Res. 2024 Jan ;73(1):47-63. Epub 2023 Dec 26. PMID: 38147126

Article Published Date : Dec 31, 2023

Study Type : Animal Study

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Substances : Tangeretin

Diseases : Lipopolysaccharide-Induced Toxicity, Lung Damage, Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

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Tanshinone IIA alleviates early brain injury after subarachnoid hemorrhage.Jan 25, 2024

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Pubmed Data : Exp Gerontol. 2024 Jun 17:112495. Epub 2024 Jun 17. PMID: 38897393

Article Published Date : Jun 16, 2024

Study Type : Animal Study

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Substances : Naringenin

Diseases : Aging: Brain

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-18 down-regulation, Interleukin-6 Downregulation, Nrf2 activation

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The effects of curcumin on inflammasome: latest update. Jan 10, 2023

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Pubmed Data : Inflamm Bowel Dis. 2019 Aug 20 ;25(9):1510-1521. PMID: 31107535

Article Published Date : Aug 19, 2019

Study Type : Animal Study

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Substances : Cyanidin 3-glucoside

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, Interleukin-18 down-regulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage.Dec 31, 2017

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Pubmed Data : Drug Des Devel Ther. 2018 ;12:1609-1619. Epub 2018 Jun 12. PMID: 29928110

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Theaflavins

Diseases : Brain Inflammation , Cerebral Hemorrhage

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor

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Pubmed Data : Front Immunol. 2022 ;13:912933. Epub 2022 Jun 21. PMID: 35799788

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Mangiferin

Diseases : Inflammation, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, ER beta receptor up-regulation, Interleukin-18 down-regulation, NF-kappaB Inhibitor

Additional Keywords : Xanthones

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Allicin alleviated acrylamide-induced NLRP3 inflammasome activation.Jan 31, 2021

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Pubmed Data : Food Chem Toxicol. 2021 Feb ;148:111937. Epub 2020 Dec 24. PMID: 33348049

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Pubmed Data : Life Sci. 2022 Oct 24 ;310:121123. Epub 2022 Oct 24. PMID: 36302499

Article Published Date : Oct 23, 2022

Study Type : In Vitro Study

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Substances : Astragaloside

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-18 down-regulation, Interleukin-1 beta downregulation

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Astragaloside IV inhibits inflammation caused by influenza virus.May 31, 2024

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Pubmed Data : J Lipid Res. 2016 Jan ;57(1):66-76. Epub 2015 Dec 1. PMID: 26628639

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Vitamin E: Gamma-tocotrienol

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation

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Ginkgolide attenuates memory impairment and neuroinflammation by suppressing the NLRP3/caspase-1 pathway in Alzheimer's disease.Oct 02, 2023

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Pubmed Data : J Cell Physiol. 2023 Jun ;238(6):1336-1353. Epub 2023 Apr 13. PMID: 37052047

Article Published Date : May 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Lactobacillus plantarum

Diseases : Salmonella Infections

Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Licochalcone E improves insulin sensitivity in palmitic acid-treated HepG2 cells through inhibition of the NLRP3 signaling pathway.Sep 30, 2021

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Pubmed Data : Int Immunopharmacol. 2021 Oct ;99:107923. Epub 2021 Jul 3. PMID: 34229177

Article Published Date : Sep 30, 2021

Study Type : In Vitro Study

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Substances : Licorice

Diseases : Insulin Resistance

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Insulin Sensitizers, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Pubmed Data : Int Immunopharmacol. 2023 Feb ;115:109613. Epub 2022 Dec 26. PMID: 36577154

Article Published Date : Jan 31, 2023

Study Type : In Vitro Study

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Substances : Lotus

Diseases : Colitis, Inflammation, Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Oridonin attenuates myocardial ischemia/reperfusion injury.Dec 31, 2019

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Pubmed Data : Oxid Med Cell Longev. 2022 ;2022:2042163. Epub 2022 Aug 16. PMID: 36017235

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View the Evidence: 181 Abstracts with Interleukin-18 down-regulation Research

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Effect of berberine on activation of TLR4-NFκB signaling pathway and NLRP3 inflammasome in patients with gout.Sep 19, 2022

Electroacupuncture ameliorates knee osteoarthritis.Aug 11, 2024

Electroacupuncture inhibits the corneal ROS/TXNIP/NLRP3 signaling pathway in a rat model of dry eye syndrome.Sep 22, 2021

Far infrared radiation therapy provides an effective treatment modality for patients with chronic lymphedema.May 31, 2017

Long-term bicycle riding improves the quality of life and reduces the severity of depression in patients suffering from chronic hemodialysis.Dec 31, 2016

Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans.Feb 28, 2013

Anti-inflammatory activity of carvacrol protects the heart from lipopolysaccharide-induced cardiac dysfunction.Jun 30, 2023

Glycyrrhizin mitigates acute lung injury by inhibiting the NLRP3 inflammasome.Feb 28, 2023

Lutein attenuates Propionibacterium acnes-induced inflammation.Mar 31, 2023

The aqueous extracts of Ageratum conyzoides inhibit inflammation by suppressing NLRP3 inflammasome activation.Jun 11, 2023

6-shogaol and 6-gingerol active ingredients may improve neuropathic pain.Dec 31, 2022

Acacetin alleviates neuroinflammation and oxidative stress injury.Dec 31, 2021

Açai berry administration promotes wound healing.Jan 02, 2023

Acetyl-11-Keto-β-boswellic acid accelerates the repair of spinal cord injury.Dec 25, 2023

Aerobic exercise improves depressive-like behavior.Aug 08, 2023

Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in H 22 liver tumor-bearing mice.Jul 11, 2018

Apigenin ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways.Jun 13, 2019

Apigenin supplement might provide a basis for developing a new dietary strategy for the prevention of chronic ulcerative colitis.Mar 31, 2016

Arctigenin may confer protection against ischemic stroke.Nov 03, 2017

Astragaloside IV attenuates inflammatory response mediated by NLRP-3/calpain-1 is involved in the development of pulmonary hypertension.Dec 07, 2020

Astragaloside IV inhibits rotenone-induced α-syn presentation and the CD4 T-cell immune response.Aug 20, 2023

Astragaloside IV treatment ameliorated the severity of diabetic nephropathy.Dec 31, 2019

Baicalin alleviates contrast-induced acute kidney injury.Dec 31, 2021

Baicalin ameliorates atherosclerosis by inhibiting NLRP3 inflammasome in apolipoprotein E-deficient mice.Oct 31, 2020

Baicalin ameliorates lung injury.Dec 31, 2022

Baicalin could potentially prevent and improve mice lung inflammatory injury induced by PM2.5 exposure.Nov 24, 2022

Baicalin reduces the activity of the NLRP3 inflammasome and consequently inhibits cerebral ischemia-reperfusion injury.Sep 30, 2021

Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation.Sep 15, 2022

Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway.Dec 31, 2018

Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons.Jan 11, 2019

Cabbage extracts have a pancreato-protective effect.Jan 19, 2017

Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/ reperfusion injury.Nov 30, 2022

Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation.May 19, 2024

Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats.Dec 31, 2018

Celastrol relieves myocardial infarction-induced cardiac fibrosis.Jul 31, 2023

Crocin alleviates the inflammation and oxidative stress responses associated with diabetic nephropathy.Apr 25, 2021

Curcumin improves cardiac function and reduces cardiac fibrosis after myocardial infarction.Dec 31, 2020

Dietary glucoraphanin provides a dietary strategy to alleviate inflammatory bowel diseases symptoms.Dec 03, 2022

EA may be a promising therapeutic approach for extending the thrombolytic therapy window by protecting the BBB and inhibiting GSDMD-mediated pyroptosis.Dec 14, 2024

Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism.Dec 31, 2020

Effects of electroacupuncture on learning-memory function and synaptic plasticity in rats with cerebral ischemia-reperfusion injury.Sep 11, 2024

Effects of epigallocatechin-3-gallate on oxidative stress, inflammation, and bone loss in a rat periodontitis model.Sep 30, 2023

Effects of hydrogen gas on NOD-like receptor protein 3 inflammasomes in the cerebral cortex of rats with traumatic brain injury.Apr 30, 2023

Electro-acupuncture alleviates chronic unpredictable stress-induced depressive- and anxiety-like behaviour and neuroinflammation.Dec 31, 2017

Electroacupuncture alleviated post-stroke cognitive impairment.Nov 04, 2024

Electroacupuncture ameliorates inflammatory response of mice with acute myocardial ischemia.Oct 24, 2022

Electroacupuncture can alleviate the inflammatory response of synovial tissues of knee joints in knee osteoarthritis.Jun 24, 2022

Electroacupuncture can improve the neurological function and alleviate the degree of nerve injury in rats with cerebral I/R injury.Jun 24, 2022

Electroacupuncture can significantly improve the learning and memory ability of vascular dementia.Oct 24, 2022

Electroacupuncture inhibits NLRP3 activation by regulating CMPK2 after spinal cord injury.Dec 31, 2021

Electroacupuncture preconditioning prevents urticaria by regulating inflammatory response.Oct 24, 2024

Electroacupuncture prevents the depression-like behavior by inhibiting the NF-κB/NLRP3 inflammatory pathway. Jan 10, 2022

Emodin alleviated pancreatic and intestinal mucosa injury in experimental severe acute pancreatitis.Aug 14, 2017

Emodin attenuates LPS-induced acute lung injury. Nov 16, 2021

Emodin attenuates severe acute pancreatitis via antioxidant and anti-inflammatory activity.Nov 30, 2019

Enhanced anti-inflammatory effect of rosmarinic acid by encapsulation and combination with the exosome.Jul 10, 2023

Epigallocatechin gallate prevents cardiomyocytes from pyroptosis through lncRNA MEG3/TAF15/AIM2 axis in myocardial infarction.Dec 05, 2023

Fucoidan mitigates gastric ulcer injury through managing inflammation, oxidative stress, and NLRP3-mediated pyroptosis.Jun 30, 2023

Galactooligosaccharides protects against DSS-induced murine colitis.Jan 31, 2020

Gastrodin alleviates cerebral ischaemia/reperfusion injury.Jun 30, 2021

Gastrodin is anti-inflammatory as it effectively suppresses inflammasome in oxygen-glucose-deprivation-stimulated astrocytes.Jun 18, 2019

Geraniol isolated from lemon grass to mitigate doxorubicin-induced cardiotoxicity through Nrf2 and NF-κB signaling.Jul 30, 2021

Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic-ischemic brain injury.Sep 30, 2018

Ginsenoside Rg1 alleviates acute liver injury through the induction of autophagy.Dec 31, 2020

Ginsenoside Rg1 can inhibit inflammatory reaction, regulate lipid metabolism, and alleviate liver injury in NAFLD.May 18, 2020

Ginsenoside Rg1 may have protective effects on neuroinflammation and neuronal injury induced by chronic glucocorticoids exposure.Sep 30, 2017

Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetes. Jan 04, 2020

Ginsenosides Rb1 attenuates chronic social defeat stress-induced depressive behavior.Dec 31, 2021

Glabridin attenuates lipopolysaccharide-induced acute lung injury.Mar 20, 2017

Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury.Jun 11, 2019

Gypenosides improve diabetic cardiomyopathy by inhibiting ROS‐mediated NLRP3 inflammasome activation.Dec 31, 2017

Honokiol could alleviate lipopolysaccharide-induced acute lung injury by reducing the oxidative stress and inhibiting NLRP3 inflammasome.Nov 28, 2021

Interleukin-18 down-regulation

View the Evidence:
181 Abstracts with Interleukin-18 down-regulation Research