Interleukin-6 Downregulation

Name	AC	CK
Curcumin	112	299
Flavonoids	154	276
Berberine	69	236
Resveratrol	58	211
Probiotics	29	170
Ginsenosides	78	162
Vitamin C	30	147
Vitamin D	34	143
Coenzyme Q10	18	135
Omega-3 Fatty Acids	14	106
Polyphenols	49	106
Astaxanthin	38	101
Pomegranate	17	90
Ginkgo biloba	34	84
Astragaloside	45	78
Paeoniflorin	44	78
Thymoquinone	35	77
Lycopene	23	75
Almond	6	72
Quercetin	39	70
Peony	31	66
Flaxseed	7	64
Luteolin	37	62
EGCG (Epigallocatechin gallate)	20	61
Lactobacillus plantarum	25	58
Melatonin	14	58
Fish Oil	7	56
Hydrogen Water	24	55
Spirulina	11	53
Sulforaphane	29	53
Tanshinone IIA	34	52
NAC (N-acetyl-L-cysteine)	9	51
Puerarin	24	50
Vitamin E	9	50
Fermented Foods and Beverages	26	49
Alpha-Lipoic Acid	7	47
Fucoidan	22	47
Sesame Seeds	8	47
Ellagic Acid	22	46
Safflower	15	46
Garlic	10	45
Nigella sativa (aka Black Seed)	13	45
Saffron	12	45
Sinomenine	17	45
Ginger	24	44
Rose	21	43
Turmeric	23	43
Crocin	14	41
DHA (Docosahexaenoic Acid)	9	41
Frankincense	16	41
Ginseng	10	41
Reishi Mushroom	22	41
Citrus naringin	25	40
Anthocyanins	19	39
Cannabidiol	20	39
Garlic: Aged	7	39
Salvia miltiorrhiza	22	39
Paeonol	22	38
Green Tea	19	37
Hesperidin	23	37
Chlorogenic Acid	16	36
Lactoferrin	10	36
Diosmin	15	35
Palmitoylethanolamide	6	35
Punicalagin	16	35
Tart Cherry	4	35
Ashwagandha	16	34
Gastrodin	14	34
Lactobacillus casei	9	34
Lactobacillus fermentum	14	34
Moringa oleifera	22	33
Dandelion	19	32
Genistein	15	32
Grape Seed Extract	12	32
Ursolic Acid	8	32
Andrographis	14	31
Apigenin	20	31
Chrysin	19	31
Fisetin	15	31
Lactobacillus Acidophilus	7	31
Tomato	3	31
Tripterygium wilfordii	2	31
Folic Acid	2	30
Panax Notoginseng	16	30
Piperine	10	30
Bee Propolis	9	29
Burdock	11	29
Naringenin	18	29
Pterostilbene	14	28
Red Sage	11	28
Fucoxanthin	11	27
Honokiol	15	27
Kaempferol	17	27
Leonurine	12	27
Patchouli	17	27
Purslane	15	27
Hydrogen: Molecular	5	26
Magnolol	15	26
Sea buckthorn	14	26
Sesamin	6	26
Yoghurt	5	26
Astragalus	10	25
Catechin	4	25
Cinnamaldehyde	9	25
Glycyrrhizin	9	25
Icariin	14	25
Lactobacillus rhamnosus GG	9	25
Mulberry	16	25
Royal Jelly	9	25
Allicin	14	24
Diosgenin	11	24
Gallic Acid	12	24
Lotus	13	24
Nobiletin	15	24
Silymarin	4	24
Strawberry	4	24
Apple	4	23
Asiatic Acid	15	23
Barberry	2	23
Isoflavones	4	22
Mangiferin	14	22
Olive Oil	3	22
Phloretin	12	22
Silibinin	9	22
Vitamin B-12	3	22
Whey	8	22
Black Raspberry	8	21
Emodin	13	21
Ginseng (Korean)	12	21
Goji	12	21
Honey	5	21
Oleuropein	10	21
Syringic Acid	9	21
Echinacea	13	20
Shikonin	12	20
Soy Protein	2	20
Baicalein	10	19
Bee Venom	12	19
Black Currant	6	19
Bromelain	6	19
Formononetin	11	19
Honeysuckle	12	19
Kefir	10	19
Lactobacillus reuteri	10	19
Lactobacillus rhamnosus	10	19
Myricetin	12	19
Rosmarinic acid	8	19
Bifidobacterium Longum	5	18
Blueberry	12	18
Caffeic acid phenethyl ester	6	18
Eugenol	9	18
Lactobacillus probiotics	5	18
Olive leaf extract	5	18
Plantago	6	18
Vitexins	8	18
Aloe Vera	10	17
Beta-glucan	5	17
Celastrol	11	17
Chokeberry	11	17
Elderberry	5	17
Ferulic acid	10	17
Nettle	5	17
Olive	6	17
Wogonin	12	17
Amla Fruit	5	16
Cyanidin 3-glucoside	4	16
Hemp Seed	6	16
Indole-3-Carbinol	8	16
Perilla	9	16
Pomegranate Peel	4	16
Pumpkin Seeds	4	16
Vitamin E: alpha tocopherol	4	16
beta-Carotene	4	16
Black Tea	8	15
Cinnamon	4	15
Cordyceps Militaris	8	15
Hydroxytyrosol	4	15
Isothiocyanate	4	15
Lactobacillus paracasei	8	15
Licorice	9	15
Orange	4	15
Psilocybin	4	15
Raspberry	8	15
Urolithin A	10	15
Betulinic acid	9	14
Biochanin A	8	14
Cardamonin	4	14
Carnosic Acid	7	14
Carotenoids	5	14
Chlorella (Algae)	4	14
Coconut Oil	3	14
EPA (Eicosapentaenoic Acid)	3	14
Lutein	5	14
Verbascoside	8	14
Andrographolide	9	13
Dogwood	8	13
Ligustrazine	7	13
Lychee	5	13
Magnesium	3	13
Papaya	3	13
Parthenolide	8	13
Seaweed: Brown	9	13
Zataria multiflora	3	13
Chrysanthemum Indicum	7	12
Crocetin	7	12
Evening Primrose Oil	2	12
Flaxseed Oil	2	12
Geraniol	7	12
Gotu Kola	8	12
Hawthorn	7	12
L-Carnitine	2	12
L-arginine	2	12
Lion's Mane (Hericium Erinaceus)	7	12
Mastic gum	2	12
Medicinal Mushrooms	6	12
Noni	2	12
Nuts	3	12
Phlorotannins	8	12
Porridge	2	12
Rosemaric Acid	8	12
Selenium	8	12
Tangeretin	7	12
Tocotrienols	2	12
Vanillin	8	12
Vitamin B-6	2	12
Yerba Mate	2	12
Beta-Caryophyllene	7	11
Bilberry	2	11
Boswellia	2	11
Broccoli Sprouts	2	11
Carnosol	5	11
Lactobacillus delbrueckii Subsp	2	11
P-Coumaric Acid	6	11
Piceatannol	8	11
Pine Bark Extract	2	11
Rutin	8	11
Watercress	2	11
Amygdalin	5	10
Antioxidant formulas	1	10
Apocynin	5	10
Bacillus coagulans	1	10
Beta-Elemene	6	10
Betaine	1	10
Bitter Melon	7	10
Capsaicin	6	10
Carnitine	1	10
Celery Oil	1	10
Chaga Mushroom (Inonotus obliquus)	6	10
Chocolate	1	10
Cruciferous Vegetables	1	10
Delphinidin	1	10
Epicatechin	1	10
Fiber	1	10
Folate	1	10
Gingerol	7	10
Guduchi	6	10
Hops	6	10
Inulin	1	10
Isoliquiritigenin	6	10
Isothiocyanates	6	10
Marshmallow Root	1	10
Passion fruit	1	10
Persimmon	6	10
Poria cocos	6	10
Prunella vulgaris	6	10
Pycnogenol (Pine Bark)	1	10
Raisins	1	10
Red Wine Extract	1	10
Resistant Starch	1	10
Soup	1	10
Stilbenes	6	10
Thunder god vine	1	10
Tocotrienol: Delta	1	10
Ubiquinol	1	10
Vitamin A	1	10
Water: Electrolyzed Reduced	1	10
yerba de tago	1	10
6-Shogaol	5	9
Adlay	6	9
Artesunate	5	9
Citrus Peel	5	9
Fig	4	9
Genipin	5	9
Neem	5	9
Saikosaponin	6	9
Sweet Potato: Purple	6	9
Walnut	5	9
Zerumbone	6	9
Agaricus Blazei	4	8
Bamboo	3	8
Citrus Triterpenoids	4	8
Eriodictyol	6	8
Nicotinamide Mononucleotide	4	8
Piperlongumine	5	8
Scopoletin	5	8
Vanillic Acid	5	8
White Tea	4	8
Arctigenin	4	7
Artichoke	5	7
Dates	4	7
Hibiscus sabdariffa	4	7
Manuka Honey	5	7
Oleanolic acid	4	7
Oleocanthal	2	7
Oligosaccharides	4	7
Oridonin	5	7
Sesamol	4	7
Shitake Mushroom	5	7
Theaflavins	4	7
Alpha Linolenic Acid	3	6
Bergamot	4	6
Carvacrol	6	6
Citral	3	6
Cranberry	4	6
Diosmetin	2	6
Eucalyptus	3	6
FOS (Fructooligosaccharides)	3	6
Garcinia kola	4	6
Gold (nanoparticles)	3	6
Guava	3	6
Histidine	3	6
Hu Zhang (Polygonum cuspidatum)	3	6
Huperzine	3	6
Jujube	4	6
Lignans	4	6
Liquiritigenin	4	6
Lupeol	3	6
Mangosteen	4	6
Mucuna pruriens (aka Velvet Beans)	4	6
Oligonol	3	6
Pectin	3	6
Procyanidin B2	4	6
Propolis: Brazillian	3	6
Rice	3	6
Rooibos	3	6
Rosemary	4	6
Schisandra	3	6
Shiitake Mushroom	3	6
Xanthohumol	4	6
Yellow Tea	3	6
Agrimony	3	5
Babchi	4	5
Beta Sitosterol	3	5
Bifidobacterium Bifidum	3	5
Bitter Apple	3	5
Bitter Orange	4	5
Black Pepper	4	5
Caffeic Acid	3	5
Cocoa	3	5
Elecampane	4	5
Horse Chestnut	3	5
Japanese cypress	3	5
Krill	3	5
Lactobacillus gasseri	4	5
Maitake Mushroom	3	5
Myrrh	3	5
Niacinamide	1	5
Organosulfur Compounds	3	5
Pine Needle	4	5
Propolis: Bee	3	5
Safranal	3	5
Silver (nanoparticles)	3	5
Terminalia	2	5
Theanine	3	5
Thyme	4	5
Velvet antler	2	5
acetyl-11-keto-beta-boswellic acid	3	5
Acai	2	4
Arginine	2	4
Bacopa	3	4
Bael	2	4
Beans: All	2	4
Bee Pollen	2	4
Bifidobacterium	2	4
Bifidobacterium Infantis	2	4
Bifidobacterium Lactis	2	4
Blackberry	2	4
Boron	2	4
Brown Rice: Pre-Germinated	2	4
Buckwheat	2	4
Camel Milk	2	4
Carnosine	2	4
Chamomile	3	4
Chinese Skullcap	2	4
Citrulline	2	4
Cordyceps sinensis	2	4
Corn: Purple	2	4
Daidzein	3	4
Elm tree	2	4
Fenugreek	3	4
Geranium	2	4
Harmine	2	4
Kimchi	3	4
Kombucha Tea	3	4
Lactobacillus Brevis	3	4
Lactobacillus helveticus	2	4
Lavender	2	4
Loquat	2	4
Milk Thistle	2	4
Mint	3	4
Mussel: Green-lipped (Perna canaliculus)	2	4
Nattokinase	2	4
Onion	2	4
Oolong tea	2	4
Passion Flower	2	4
Perillaldehyde	2	4
Policosanol	2	4
Purple Carrots	3	4
Red Yeast Rice	2	4
Sembung Leaf	3	4
Sesame Seed Oil	2	4
Soy	2	4
St. Johns Wort	2	4
Sweet Potato	2	4
Tetrahydrocurcumin	2	4
Thymol	3	4
Tomatidine	2	4
Vinpocetine	2	4
Vitamin B12	2	4
Zeaxanthin	3	4
Angelica	2	3
Apple Cider Vinegar	2	3
Banana	2	3
Barley	2	3
Cannabichromene	1	3
Cannabinoids	3	3
Carbon 60	1	3
Carrot	2	3
Chia	2	3
Cucurbitacin B	2	3
Cucurbitacin E	2	3
Curcumin: Degradiation byproducts	2	3
Garcinia Mangostana	2	3
Garden Cress (Lepidium sativum)	2	3
Grape	2	3
Hibiscus	3	3
Justicia gendarussa	2	3
Kiwifruit	2	3
Litchi	2	3
Loquat Leaves	2	3
MSM (Methylsulfonylmethane)	2	3
Mushrooms: All	2	3
Oats	2	3
Peanut	2	3
Phenethyl isothiocyanate	2	3
Pistachio nut	2	3
Quince	2	3
Red Clover	2	3
Red Marine Algae	2	3
Sage	3	3
Sarsaparilla	2	3
Seaweed	2	3
Soybean: Black	2	3
Tamarind	1	3
Tea: Oolong	1	3
Vitex negundo	2	3
Wheat Germ	2	3
White Mulberry	3	3
Xanthones	2	3
18β-Glycyrrhetinic Acid	1	2
5-HTP (5-Hydroxytryptophan)	1	2
ALA (Alpha-Linolenic Acid)	1	2
Aduki bean	1	2
African Basil	1	2
Antrodia Camphorate	1	2
Asparagus	1	2
Banaba	1	2
Banana Leaf	1	2
Basil	1	2
Basil: Sweet	2	2
Bay Laurel	1	2
Bifidobacterium Breve	1	2
Billygoat Weed	1	2
Bixin	1	2
Blue Honeysuckle	1	2
Brown Rice	1	2
Bufalin	1	2
Butterfly Pea	1	2
Butyrate	1	2
Cannabis	2	2
Carrageenans	1	2
Celadrin	1	2
Celery	1	2
Chaenomeles speciosa	1	2
Chicoric Acid	1	2
Chondroitin Sulfate	1	2
Coffee: Green/Unroasted	1	2
Common bean	1	2
Curcumol	2	2
Cystine	1	2
D-Chiro-Inositol	1	2
Diallyl sulfide	1	2
Dill	1	2
Dong Quai	1	2
Essential Oils: Unspecified	1	2
Galactooligosaccharides	1	2
Ganoderic acid B	1	2
Ginseng (American)	1	2
Goldenrod	1	2
Guarana	1	2

[+]

Acupuncture and moxibustion has a good effect on Myasthenia gravis, which is better than conventional Western medicine.May 02, 2024

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Ginkgo biloba extract as adjuvant therapy for intracerebral hemorrhage has better efficacy and is relatively safe compared with conventional treatment alone.Mar 14, 2024

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Pubmed Data : Heliyon. 2024 Mar 15 ;10(5):e26861. Epub 2024 Feb 23. PMID: 38439880

Article Published Date : Mar 14, 2024

Study Type : Meta Analysis, Review

Additional Links

Substances : Ginkgo biloba

Diseases : Intracerebral Hemorrhage

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ginseng supplementation may be an effective strategy for improving cardiometabolic profiles in individuals with prediabetes and T2DM.Jun 08, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

The beneficial effect of tart cherry on plasma levels of inflammatory mediators (not recovery after exercise).Aug 31, 2022

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Pubmed Data : Complement Ther Med. 2022 Sep ;68:102842. Epub 2022 May 30. PMID: 35653966

Article Published Date : Aug 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Effects of sesame consumption on inflammatory biomarkers in humans.Dec 31, 2020

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Pubmed Data : Evid Based Complement Alternat Med. 2021 ;2021:6622981. Epub 2021 Nov 1. PMID: 34760018

Article Published Date : Dec 31, 2020

Study Type : Meta Analysis, Review

Additional Links

Substances : Sesame Seeds

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Efficacy and safety of sinomenine for diabetic kidney diseases.Dec 28, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Pharmacol Res. 2016 Jul 5. Epub 2016 Jul 5. PMID: 27392742

Article Published Date : Jul 04, 2016

Study Type : Meta Analysis

Additional Links

Substances : Curcumin

Diseases : Inflammation

Pharmacological Actions : Interleukin-6 Downregulation

[+]

Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Vitamin C supplementation attenuates the oxidative stress and inflammatory response to a single bout of exercise.Mar 10, 2020

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Pubmed Data : Eur J Nutr. 2020 Mar 11. Epub 2020 Mar 11. PMID: 32162041

A hydro alcoholic extract of nettle could decrease the levels of IL-6 and hs-CRP in patients with type 2 diabetes.Jul 31, 2011

Click here to read the entire abstract

Pubmed Data : Pak J Biol Sci. 2011 Aug 1 ;14(15):775-9. PMID: 22303583

Article Published Date : Jul 31, 2011

Study Type : Human Study

Additional Links

Substances : Nettle

Diseases : C-Reactive Protein, Diabetes Mellitus: Type 2, Inflammation, Insulin Resistance

Therapeutic Actions : Placebo Effect

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

Additional Keywords : Plant Extracts

[+]

A single vitamin D3 bolus supplementation improves vitamin D status and reduces proinflammatory cytokines.Sep 23, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer.Apr 19, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2023 Apr 20 ;13(1):6449. Epub 2023 Apr 20. PMID: 37081029

Article Published Date : Apr 19, 2023

Study Type : Human Study

Additional Links

Substances : Evening Primrose Oil, Fish Oil

Diseases : Breast Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Chemotherapeutic, Interleukin-6 Downregulation

[+]

Anti-inflammatory effects of diet and caloric restriction in metabolic syndrome.Mar 07, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Front Endocrinol (Lausanne). 2023 ;14:1144323. Epub 2023 Mar 20. PMID: 37020589

Article Published Date : Dec 31, 2022

Study Type : Human Study

Additional Links

Substances : Astaxanthin

Diseases : Endometriosis, Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Astaxanthin treatment decreases pro-inflammatory cytokines and improves reproductive outcomes in patients with polycystic ovary syndrome undergoing assisted reproductive technology.Jul 31, 2024

Click here to read the entire abstract

Pubmed Data : Inflammopharmacology. 2024 Aug ;32(4):2337-2347. Epub 2024 Jun 25. PMID: 38916710

Article Published Date : Jul 31, 2024

Study Type : Human Study

Additional Links

Substances : Astaxanthin

Diseases : Oxidative Stress, Polycystic Ovary Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

[+]

Astragalosides supplementation enhances intrinsic muscle repair capacity following eccentric exercise-induced injury.Oct 16, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2022 Oct 17 ;14(20). Epub 2022 Oct 17. PMID: 36297022

Article Published Date : Oct 16, 2022

Berberine possesses potential lipid-regulating, antiarthritis, and synovial hyperplasia inhibition activities against rheumatoid arthritis.Dec 31, 2018

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Bromelain-loaded nanocomposites decrease inflammatory and cytotoxicity effects of gliadin on Caco-2 cells and peripheral blood mononuclear cells of celiac patients.Nov 30, 2023

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Children and adolescents with ADHD who received Lactobacillus rhamnosus GG supplementation reported better health-related quality of life.Dec 31, 2019

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Pubmed Data : Front Psychiatry. 2020 ;11:181. Epub 2020 Mar 17. PMID: 32256407

Article Published Date : Dec 31, 2019

Study Type : Human Study

Additional Links

Substances : Lactobacillus rhamnosus GG

Diseases : Attention Deficit Disorder with Hyperactivity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Chlorella ingestion may be useful in preventing or ameliorating the course of type 2 diabetes development.May 31, 2015

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Pubmed Data : Clin Nutr ESPEN. 2015 Jun ;10(3):e95-e101. Epub 2015 May 21. PMID: 28531388

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Diet Suppl. 2016 ;13(1):1-15. Epub 2014 Aug 25. PMID: 25153307

Article Published Date : Dec 31, 2015

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Pubmed Data : BMC Geriatr. 2019 Aug 12 ;19(1):218. Epub 2019 Aug 12. PMID: 31405365

Article Published Date : Aug 11, 2019

Study Type : Human Study

Additional Links

Diseases : Diabetes Mellitus: Type 2, Neuropathic Pain

Therapeutic Actions : Laser Treatment

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

[+]

Defatted flaxseed flour improves weight loss and lipid profile in overweight and obese adults.Sep 22, 2020

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Pubmed Data : Food Funct. 2020 Sep 23 ;11(9):8237-8247. PMID: 32966475

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Pubmed Data : Nephrol Dial Transplant. 2006 Aug;21(8):2239-46. Epub 2006 Jun 9. PMID: 16766544

Article Published Date : Aug 01, 2006

Study Type : Human Study

Additional Links

Substances : Isoflavones

Diseases : C-Reactive Protein, Hemodialysis, Inflammation, Kidney Failure

Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee osteoarthritis.Aug 27, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2017 Aug 28 ;9(9). Epub 2017 Aug 28. PMID: 28846633

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Pubmed Data : J Sport Exerc Psychol. 2019 Apr 1 ;41(2):96-106. Epub 2019 Apr 26. PMID: 31027457

Article Published Date : Mar 31, 2019

Study Type : Human Study

Additional Links

Diseases : C-Reactive Protein, Inflammation

Therapeutic Actions : Exercise: Aerobic, Mindfullness Training

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

[+]

Docosahexaenoic acid counteracts the hypoxic-induced inflammatory and metabolic alterations.Oct 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Eur J Clin Nutr. 2019 Feb ;73(2):258-265. Epub 2018 Aug 20. PMID: 30127374

Article Published Date : Jan 31, 2019

Study Type : Human Study

Additional Links

Substances : Flaxseed

Diseases : C-Reactive Protein, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Effect of high-dose Spirulina supplementation on hospitalized adults with COVID-19.Dec 31, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Phytother Res. 2022 Jun ;36(6):2605-2615. Epub 2022 Apr 26. PMID: 35470916

Article Published Date : May 31, 2022

Study Type : Human Study

Additional Links

Substances : Crocin

Diseases : Insulin Resistance, Polycystic Ovary Syndrome

Pharmacological Actions : Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Effects of N-acetylcysteine on aging cell and obesity complications in obese adults.Dec 31, 2022

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Pubmed Data : Cureus. 2023 Jul ;15(7):e41377. Epub 2023 Jul 4. PMID: 37546047

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Pubmed Data : Cancer Prev Res (Phila). 2015 Nov 24. Epub 2015 Nov 24. PMID: 26603740

Article Published Date : Nov 23, 2015

Study Type : Human Study

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Diseases : C-Reactive Protein, Inflammation

Therapeutic Actions : Exercise

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

[+]

Fermented Carica papaya and Morinda citrifolia as perspective food supplements for the treatment of post-COVID symptoms.May 24, 2022

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Pubmed Data : Clin Nutr. 2017 Jun 1. Epub 2017 Jun 1. PMID: 28647291

Article Published Date : May 31, 2017

Study Type : Human Study

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Substances : Genistein

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Genistein, Nonalcoholic fatty liver disease (NAFLD)

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Ginkgo is effective in treating pulmonary interstitial fibrosis.Mar 01, 2005

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Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Mar;25(3):222-4. PMID: 15842142

Article Published Date : Mar 01, 2005

Study Type : Human Study

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Substances : Ginkgo biloba

Diseases : Interstitial Lung Diseases, Pulmonary Fibrosis

Pharmacological Actions : Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substances Versus Drugs

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Impact of resveratrol supplementation on inflammatory, antioxidant, and periodontal markers in type 2 diabetic patients with chronic periodontitis.Jul 31, 2019

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Pubmed Data : Diabetes Metab Syndr. 2019 Jul - Aug;13(4):2769-2774. Epub 2019 Jul 24. PMID: 31405706

Article Published Date : Jul 31, 2019

Study Type : Human Study

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Substances : Resveratrol

Diseases : Diabetes Mellitus: Type 2, Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation

[+]

Improvement of inflammatory status following saffron and resistance training in elderly hypertensive men.May 31, 2022

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Pubmed Data : Exp Gerontol. 2022 Jun 1 ;162:111756. Epub 2022 Feb 27. PMID: 35235859

Article Published Date : May 31, 2022

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Pubmed Data : J Nutr. 2008 Apr ;138(4):732-9. PMID: 18356328

Article Published Date : Apr 01, 2008

Study Type : Human Study

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Substances : Fiber

Diseases : Adiponectin: Low Levels, Inflammation, Insulin Resistance

Pharmacological Actions : Adiponectin upregulation, Interleukin-6 Downregulation

Problem Substances : Insulin

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Infrared low-level laser therapy therapy before intense progressive running test of high-level soccer players.Dec 31, 2018

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Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:6239058. Epub 2019 Nov 16. PMID: 31827687

Article Published Date : Dec 31, 2018

Study Type : Human Study

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Diseases : Inflammation, Muscle Damage: Exercise-Induced, Oxidative Stress

Therapeutic Actions : Photobiomodulation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation

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Intake of bilberries has an ameliorating effect on some markers of gingival inflammation reducing gingivitis to a similar extent compared to standard of care.Dec 31, 2014

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Pubmed Data : Nutrients. 2019 Feb 7 ;11(2). Epub 2019 Feb 7. PMID: 30736479

Article Published Date : Feb 06, 2019

Study Type : Human Study

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Substances : Lactobacillus plantarum

Diseases : Athletic Performance, Inflammation

Therapeutic Actions : Exercise

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Lactobacillus acidophilus modulates inflammatory activity by regulating the TLR4 and NF-κB expression in porcine peripheral blood mononuclear cells.Feb 27, 2016

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Pubmed Data : Br J Nutr. 2016 Feb 28 ;115(4):567-75. Epub 2016 Jan 15. PMID: 26769562

Article Published Date : Feb 27, 2016

Study Type : Human Study

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Substances : Lactobacillus Acidophilus

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-4 upregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Lactobacillus casei modulates inflammatory cytokines and metabolites during tuberculosis treatmentFeb 28, 2022

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Pubmed Data : Asia Pac J Clin Nutr. 2022 Mar ;31(1):66-77. PMID: 35357105

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Pubmed Data : Front Immunol. 2023 ;14:1282280. Epub 2024 Jan 12. PMID: 38283346

Article Published Date : Dec 31, 2022

Study Type : Human Study

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Substances : Glycyrrhizin

Diseases : Coronavirus Disease (Covid-19)

Pharmacological Actions : Antiviral Agents, Immunomodulatory, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Cytokine Storm

[+]

Nigella sativa oil mouth rinse improves chemotherapy-induced oral mucositis in patients with acute myeloid leukemia.Dec 31, 2018

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Pubmed Data : Clin Nutr. 2017 Sep 23. Epub 2017 Sep 23. PMID: 28987470

Article Published Date : Sep 22, 2017

Study Type : Human Study

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Substances : Omega-3 Fatty Acids

Diseases : Duchenne's Muscular Dystrophy

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation

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Omega-3 supplementation improves isometric strength in response to resistance exercise in healthy older adults.Feb 24, 2021

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Pubmed Data : J Gerontol A Biol Sci Med Sci. 2021 Feb 25 ;76(3):406-414. PMID: 33284965

Article Published Date : Feb 24, 2021

Study Type : Human Study

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Substances : Omega-3 Fatty Acids

Diseases : Sarcopenia

Therapeutic Actions : Exercise: Resistance Training

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

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One week of magnesium supplementation lowers IL-6, muscle soreness and increases post-exercise blood glucose in response to downhill running.Oct 16, 2019

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Pubmed Data : Eur J Appl Physiol. 2019 Oct 17. Epub 2019 Oct 17. PMID: 31624951

Article Published Date : Oct 16, 2019

Study Type : Human Study

Additional Links

Substances : Magnesium

Diseases : Muscle Soreness

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation

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Oral administration of tannase-treated green tea extract containing antioxidants without concomitant exercise can improve muscle mass and strength.Jun 24, 2021

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Pubmed Data : Antioxidants (Basel). 2021 Jun 25 ;10(7). Epub 2021 Jun 25. PMID: 34202133

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Pubmed Data : J Appl Oral Sci. 2024 ;32:e20240047. Epub 2024 Jun 21. PMID: 38922243

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Pubmed Data : Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221121313. PMID: 35968550

Article Published Date : Dec 31, 2021

Study Type : Human Study

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Substances : Rose

Diseases : Arsenic Poisoning, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-6 Downregulation, STAT3 Inhibitor

Additional Keywords : Phytotherapy

Problem Substances : Arsenic

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PQQ supplementation enhanced mitochondria related functions.Nov 30, 2013

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Pubmed Data : Med Sci Monit. 2019 Jan 14 ;25:402-408. Epub 2019 Jan 14. PMID: 30636768

Article Published Date : Jan 13, 2019

Study Type : Human Study

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Substances : Puerarin

Diseases : Coronary Artery Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Punicalagin might be one of natural therapeutic compounds for relieving rheumatoid arthritis progression.Dec 31, 2020

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Pubmed Data : Am J Reprod Immunol. 2023 Mar ;89(3):e13644. Epub 2022 Dec 11. PMID: 36317442

Article Published Date : Feb 28, 2023

Study Type : Human Study

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Substances : Quercetin

Diseases : Inflammation, Polycystic Ovary Syndrome

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Randomized clinical trial of astaxanthin supplement on serum inflammatory markers and ER stress-apoptosis gene expression in PBMCs of women with PCOS.Jun 30, 2024

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Pubmed Data : Diabetes Res Clin Pract. 2020 Dec 25 ;172:108644. Epub 2020 Dec 25. PMID: 33359750

Article Published Date : Dec 24, 2020

Study Type : Human Study

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Diseases : Diabetes Mellitus: Type 2

Therapeutic Actions : Yoga

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypoglycemic Agents, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Role of resveratrol in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2.May 31, 2022

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Pubmed Data : Oman Med J. 2016 Jul ;31(4):263-9. PMID: 27403238

Article Published Date : Jun 30, 2016

Study Type : Human Study

Additional Links

Substances : Silibinin

Diseases : C-Reactive Protein, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Silymarin significantly reduced interleukin-6 levels, sizes of endometrioma lesions, and pain-related symptoms.Oct 19, 2022

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Pubmed Data : Sci Rep. 2022 Oct 20 ;12(1):17549. Epub 2022 Oct 20. PMID: 36266431

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Pubmed Data : Br J Clin Pharmacol. 2022 Jan 9. Epub 2022 Jan 9. PMID: 35001410

Article Published Date : Jan 08, 2022

Study Type : Human Study

Additional Links

Substances : Saffron

Diseases : Diabetes Mellitus: Type 2

Therapeutic Actions : Exercise

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection.Oct 31, 2023

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Pubmed Data : Am J Epidemiol. 2019 Nov 1 ;188(11):1944-1952. PMID: 31497846

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Pubmed Data : Med Sci (Basel). 2020 Oct 9 ;8(4). Epub 2020 Oct 9. PMID: 33050250

Article Published Date : Oct 08, 2020

Study Type : Human Study

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Substances : Royal Jelly

Diseases : Cachexia: Cancer, Cancer: Fatigue, Kidney Cancer

Pharmacological Actions : Anti-Cachexic Agents, Anti-Inflammatory Agents, Interleukin-6 Downregulation, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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View the Evidence: 3637 Abstracts with Interleukin-6 Downregulation Research

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Acupuncture and moxibustion has a good effect on Myasthenia gravis, which is better than conventional Western medicine.May 02, 2024

Anti-inflammatory and antioxidant activity of ursolic acidDec 31, 2022

Anti-inflammatory effects of resveratrol in patients with cardiovascular disease.Oct 31, 2022

Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults.Mar 31, 2023

Effects of berberine and barberry on selected inflammatory biomarkers in adults.Sep 06, 2023

Efficacy and safety of total glucosides of paeony in the treatment of 5 types of inflammatory arthritis.Aug 31, 2023

Ginkgo biloba extract as adjuvant therapy for intracerebral hemorrhage has better efficacy and is relatively safe compared with conventional treatment alone.Mar 14, 2024

Ginseng supplementation may be an effective strategy for improving cardiometabolic profiles in individuals with prediabetes and T2DM.Jun 08, 2022

Ginsenoside can protect against the renal failure in diabetes.Oct 28, 2022

Pharmacological effects of berberine on models of ulcerative colitis.Dec 31, 2021

Protective effect of berberine in diabetic nephropathy.Oct 02, 2022

Resveratrol as an anti-inflammatory agent in coronary artery disease.Jul 02, 2024

Resveratrol for inflammatory bowel disease in preclinical studies.Dec 31, 2023

The beneficial effect of tart cherry on plasma levels of inflammatory mediators (not recovery after exercise).Aug 31, 2022

The combination of tripterygium glycosides is superior to conventional DMARD monotherapy in improving rheumatoid arthritis conditions.Aug 23, 2022

The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes.Nov 03, 2022

The effects of pomegranate consumption on inflammatory and oxidative stress.Sep 30, 2023

The immunomodulatory effects of lactoferrin and its derived peptides on NF-κB signaling pathway.Jul 31, 2023

Acupuncture is beneficial for relieving pain and ameliorating quality of life and health index in patients with rheumatoid arthritis.Dec 31, 2021

Almond consumption beneficially affects CRP and IL-6 concentrations in adults.Dec 29, 2021

Alpha-lipoic acid supplementation had beneficial effects on inflammatory markers among patients with metabolic syndrome and related disorders.Dec 31, 2017

Anti-inflammatory effects of oral supplementation with curcumin.Aug 08, 2021

Antioxidant and anti-inflammatory properties of hydroxyl safflower yellow a in diabetic nephropathy.Dec 31, 2021

Beneficial effects of folic acid on inflammatory markers in the patients with metabolic syndrome.Dec 27, 2022

Coenzyme Q10 could have significant inflammatory lowering effects.Feb 04, 2017

Coenzyme Q10 supplementation may partly improve the process of inflammatory state.Dec 31, 2016

Dietary probiotics are effective in improving the symptoms of inflammatory bowel disease.Nov 26, 2019

Effectiveness of photobiomodulation in the treatment of primary burning mouth syndrome.Feb 28, 2021

Effects of probiotic supplementation on respiratory infection and immune function in athletes.Jan 21, 2021

Effects of sesame consumption on inflammatory biomarkers in humans.Dec 31, 2020

Efficacy and safety of sinomenine for diabetic kidney diseases.Dec 28, 2023

Flaxseed supplementation may improve some circulating concentrations of specific adhesion molecules and inflammatory cytokines.Nov 14, 2019

Garlic supplementation reduces circulating C-reactive protein, tumor necrosis factor, and interleukin-6 in adults.Mar 31, 2019

Meta-analysis of the effect of curcumin supplementation on skeletal muscle damage status.Dec 31, 2023

Meta-analysis: curcumin down-regulates inteleukin-6. Jul 04, 2016

Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination.Dec 31, 2013

Probiotic supplementation significantly reduced serum concentrations of pro-inflammatory cytokines.Mar 10, 2019

Probiotics lowered pro-inflammatory cytokines IL-6 in rheumatoid arthritis.Sep 14, 2017

Prolonged vitamin C supplementation has some modest beneficial effects on recovery from unaccustomed exercise.Nov 30, 2001

Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension.Apr 30, 2017

Supplementation of fish oil may reduce the circulating levels of TNF-α, IL-1 and IL-6 in patients with chronic heart failure.Dec 31, 2011

The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders.Mar 28, 2022

The effects of NAC on amending TNF-α and IL-6 levels were significant after sensitivity analysis.Jul 25, 2020

The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction.Feb 29, 2020

The present review provides the evidence of LLLT-dependent reduction of IL-1β, TNF-α, and MMP-13.Aug 23, 2020

Therapeutic effects of epigallocatechin-3-gallate for inflammatory bowel disease.May 31, 2024

This meta-analysis showed the promising effect of melatonin administration on reducing CRP and IL-6 among patients with MetS and related disorders.Jun 14, 2018

This meta-analysis suggests that resveratrol can be a clinically effective therapy for rheumatoid arthritis.Nov 04, 2021

This suggests that CQ10 supplementation likely attenuates subclinical inflammation.Aug 24, 2017

Tomato products and lycopene supplementation have positive effects on blood lipids, blood pressure and endothelial function.Jan 12, 2017

Vitamin C supplementation attenuates the oxidative stress and inflammatory response to a single bout of exercise.Mar 10, 2020

Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients.Dec 31, 2022

Anti-inflammatory effects of a period of aerobic training and vitamin D supplementation in postmenopausal women with metabolic syndrome.Dec 31, 2021

Fish Oil supplementation improves the repeated-bout effect and redox balance in 20-30-year-old men submitted to strength training.Mar 30, 2023

A combination of gastrodin, folate, and vitamin-B12 in addition to standard antiepileptic treatment can effectively control epileptic seizures.Oct 31, 2017

A dietary mixture of sesame, pumpkin and flax seed added to a habitual diet lowered triglyceride and CRP, TNF-alpha, IL-6 levelsDec 31, 2013

A hydro alcoholic extract of nettle could decrease the levels of IL-6 and hs-CRP in patients with type 2 diabetes.Jul 31, 2011

A single vitamin D3 bolus supplementation improves vitamin D status and reduces proinflammatory cytokines.Sep 23, 2022

A standardized preparation of curcuminoids compares favorably with atorvastatin on endothelial dysfunction in association with reductions in inflammatory cytokines and markers of oxidative stress. Jan 01, 2008

Active polymyalgia rheumatica is characterized by increased serum levels of Interleukin-6 probably originating in inflamed tissue. Mar 01, 2009

Adherence to the mediterranean diet is inversely associated with inflammation (circulating interleukin-6) among middle-aged men. Jan 15, 2008

Adjuvant pomegranate juice intake improves the inflammatory status of hospitalized COVID-19 patients.Jul 31, 2023

Aerobic exercise training with or without saffron supplementation on diabetes-specific markers and inflammation in women with type 2 diabetes.Jun 30, 2024

Aged garlic extract inhibits coronary artery calcification progression, lowers IL–6, glucose levels and blood pressure.Apr 28, 2020

Aged garlic extract may be beneficial in preventing the development of chronic diseases associated with low-grade inflammation.Dec 31, 2017

Almonds can be considered as part of food-based strategies for preventing pre-diabetes.Dec 31, 2020

An anthocyanin mixture reduced the inflammatory response in hypercholesterolemic subjects.Aug 31, 2013

An elemental diet reduces mucosal inflammation in patients with active Crohn's disease with remission occuring in 71% of patients. Jun 01, 2005

Andrographis paniculate might be used as a potential natural drug for treating COVID-19.Jan 31, 2023

Annatto carotenoids attenuate oxidative stress and inflammatory response after high-calorie meal in healthy subjects.Jan 09, 2017

Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer.Apr 19, 2023

Anti-inflammatory effects of diet and caloric restriction in metabolic syndrome.Mar 07, 2021

Interleukin-6 Downregulation

View the Evidence:
3637 Abstracts with Interleukin-6 Downregulation Research