Interleukin-8 downregulation

Name	AC	CK
Coenzyme Q10	3	40
Resveratrol	7	38
Curcumin	17	34
Flavonoids	21	30
Lactobacillus plantarum	5	25
Vitamin D	6	25
Fermented Foods and Beverages	5	24
Berberine	9	23
Lactobacillus Acidophilus	4	22
Probiotics	3	21
Ursolic Acid	1	21
Omega-3 Fatty Acids	2	20
Palmitoylethanolamide	2	20
Zataria multiflora	2	20
Punicalagin	5	19
Frankincense	4	15
Ginkgo biloba	5	15
Olive leaf extract	3	14
Quercetin	5	14
Fucoidan	3	13
Black Tea	3	12
EGCG (Epigallocatechin gallate)	7	12
Kefir	2	12
Lactobacillus fermentum	2	12
Lactobacillus paracasei	2	12
Milk Thistle	2	12
Red Sage	2	12
Vitamin C	3	12
Whey	2	12
Bifidobacterium Bifidum	2	11
Fisetin	2	11
Hemp Seed	2	11
Noni	2	11
Amla Fruit	1	10
Bee Propolis	1	10
Celery Oil	1	10
Epicatechin	1	10
Germanium	1	10
Japanese cypress	1	10
Lactobacillus casei	1	10
Mango	1	10
Papaya	1	10
Pine Bark Extract	1	10
Porridge	1	10
Silibinin	1	10
Tea Tree	1	10
Vitamin B-6	1	10
Zinc	1	10
Phloretin	4	9
Lotus	3	7
Sulforaphane	5	6
Allicin	4	5
Astragaloside	4	5
Cannabidiol	4	5
Celastrol	4	5
Citral	1	5
Dandelion	4	5
Diosmetin	1	5
Geranium	1	5
Ginsenosides	4	5
Niacinamide	1	5
Rosmarinic acid	1	5
Turmeric	4	5
Eriodictyol	3	4
Genistein	3	4
Luteolin	4	4
Perilla	2	4
Polyphenols	4	4
Pomegranate	2	4
Rose	3	4
Astaxanthin	3	3
Avocado	2	3
Babchi	2	3
Betulinic acid	2	3
Blueberry	2	3
Bromelain	1	3
Chokeberry	3	3
Elecampane	2	3
Feverfew	2	3
Ginseng (Korean)	1	3
Goji	2	3
Grape Seed Extract	2	3
Hydroxytyrosol	2	3
Lycopene	2	3
Magnolol	2	3
Melatonin	3	3
Oats	2	3
Panax Notoginseng	2	3
Puerarin	2	3
Sea buckthorn	2	3
Sinomenine	2	3
Terminalia	1	3
Theaflavins	2	3
Artesunate	1	2
Ashwagandha	2	2
Biochanin A	1	2
Bitter Melon	1	2
Bixin	1	2
Cannabinoids	2	2
Cardamonin	1	2
Carnosic Acid	1	2
Carrot	2	2
Carvacrol	2	2
Catechin	2	2
Chaga Mushroom (Inonotus obliquus)	1	2
Choline	1	2
Citrus naringin	1	2
Cordyceps Militaris	1	2
Daidzein	2	2
Deguelin	1	2
Dogwood	2	2
Echinacea	2	2
Emodin	1	2
Geraniol	1	2
Ginseng	1	2
Ginseng (American)	1	2
Green Coffee Bean	1	2
Green Tea	2	2
Guduchi	1	2
Lactobacillus rhamnosus	1	2
Leonurine	1	2
Licorice	1	2
Mugwort	1	2
Myricetin	1	2
NAC (N-acetyl-L-cysteine)	1	2
Naringenin	2	2
Olive	1	2
Oridonin	2	2
Paeoniflorin	2	2
Parthenolide	2	2
Peony	2	2
Piperine	2	2
Poria cocos	1	2
Prunella vulgaris	1	2
Raisins	2	2
Reishi Mushroom	2	2
Rice	1	2
Saffron	1	2
Salvia miltiorrhiza	1	2
Shikonin	2	2
Shitake Mushroom	2	2
Syringic Acid	1	2
Tanshinone IIA	2	2
Thyme	2	2
Thymol	1	2
Turmerones	1	2
Vitamin E: alpha tocopherol	1	2
Vitexins	1	2
Wogonin	2	2
Xanthones	1	2
Yarrow	1	2
Acorus calamus	1	1
Alpha Linolenic Acid	1	1
Apigenin	1	1
Apple	1	1
Arginine	1	1
Artichoke	1	1
Asiatic Acid	1	1
Astragalus	1	1
Bee Venom	1	1
Beta-glucan	1	1
Bisdemethoxycurcumin	1	1
Bitter Apple	1	1
Caffeic acid phenethyl ester	1	1
Caffeoylquinic Acids	1	1
Cannabis	1	1
Capsaicin	1	1
Carotenoids	1	1
Chamomile	1	1
Cherry: All Varieties	1	1
Chlorogenic Acid	1	1
Chrysanthemum Morifolium	1	1
Cinnamaldehyde	1	1
Cranberry Proanthocyanidins	1	1
Crocetin	1	1
Cucumber	1	1
Cucurbitacin E	1	1
Culinary Herbs and Spices	1	1
Cyanidin 3-glucoside	1	1
Eugenol	1	1
Fenugreek	1	1
Ferulic acid	1	1
Fruit: All	1	1
Gallic Acid	1	1
Garcinia kola	1	1
Ginger	1	1
Glutamine	1	1
Glycyrrhizin	1	1
Grape	1	1
Hawthorn	1	1
Hesperidin	1	1
Honeysuckle	1	1
Honokiol	1	1
Hops	1	1
Icariin	1	1
Indigo Naturalis	1	1
Isothiocyanate	1	1
Jujube	1	1
Legumes	1	1
Lentinan	1	1
Lion's Mane (Hericium Erinaceus)	1	1
Lutein	1	1
Maca	1	1
Mangiferin	1	1
Moringa oleifera	1	1
Motherwort	1	1
Mululuza	1	1
Myrtle	1	1
Nettle	1	1
Nobiletin	1	1
Oleuropein	1	1
Orange	1	1
Palash	1	1
Passion Flower	1	1
Patchouli	1	1
Piceatannol	1	1
Plantago	1	1
Propolis: Bee	1	1
Psyllium	1	1
Purple Carrots	1	1
Raspberry	1	1
Rosemaric Acid	1	1
Royal Jelly	1	1
Sage	1	1
Saw Palmetto	1	1
Scopoletin	1	1
Seaweed	1	1
Seaweed: Brown	1	1
Selenium	1	1
Skullcap: Chinese	1	1
Sophora Flavescens	1	1
Soybean: Black	1	1
Strawberry	1	1
Sumac	1	1
Sweet Potato: Purple	1	1
Thistle	1	1
Thymoquinone	1	1
Tripterygium wilfordii	1	1
Turkey Tail Mushroom	1	1
Vanillic Acid	1	1
Vegetables: All	1	1
Vitex negundo	1	1
White Mulberry	1	1
Xanthohumol	1	1
Zeaxanthin	1	1

[+]

Anti-inflammatory and antioxidant activity of ursolic acidDec 31, 2022

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Pubmed Data : Front Pharmacol. 2023 ;14:1256946. Epub 2023 Sep 28. PMID: 37841938

Article Published Date : Dec 31, 2022

Study Type : Meta Analysis, Review

Additional Links

Substances : Ursolic Acid

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Resveratrol for inflammatory bowel disease in preclinical studies.Dec 31, 2023

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Pubmed Data : Minerva Med. 2018 Dec ;109(6):418-428. Epub 2018 Sep 13. PMID: 30221912

Article Published Date : Nov 30, 2018

Study Type : Human Study

Additional Links

Substances : Omega-3 Fatty Acids, Probiotics

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interferon Gamma Reducer, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Coenzyme Q10 supplementation could be effective in ameliorating inflammatory cytokine levels caused by breast cancer.Dec 31, 2018

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Pubmed Data : Comb Chem High Throughput Screen. 2024 Aug 12. Epub 2024 Aug 12. PMID: 39136509

Article Published Date : Aug 11, 2024

Study Type : Human Study

Additional Links

Diseases : Osteoarthritis: Knee

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-8 downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor

[+]

Fermented Carica papaya and Morinda citrifolia as perspective food supplements for the treatment of post-COVID symptoms.May 24, 2022

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Lactobacillus acidophilus modulates inflammatory activity by regulating the TLR4 and NF-κB expression in porcine peripheral blood mononuclear cells.Feb 27, 2016

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Pubmed Data : Br J Nutr. 2016 Feb 28 ;115(4):567-75. Epub 2016 Jan 15. PMID: 26769562

Article Published Date : Feb 27, 2016

Study Type : Human Study

Additional Links

Substances : Lactobacillus Acidophilus

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Interferon Gamma Reducer, Interleukin-10 upregulation, Interleukin-4 upregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation.Feb 16, 2021

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Pubmed Data : J Appl Oral Sci. 2024 ;32:e20240047. Epub 2024 Jun 21. PMID: 38922243

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Pubmed Data : Respir Med. 2008 Nov 14. PMID: 19010653

Article Published Date : Nov 14, 2008

Study Type : Human Study

Additional Links

Substances : Quercetin

Diseases : Sarcoidosis

Pharmacological Actions : Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : J Ethnopharmacol. 2016 Dec 24 ;194:1069-1077. Epub 2016 Oct 27. PMID: 27989874

Article Published Date : Dec 23, 2016

Study Type : Human Study

Additional Links

Substances : Black Tea

Diseases : Diabetes Mellitus: Type 2, Inflammation

Pharmacological Actions : Hypoglycemic Agents, Hypolipidemic, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-8 downregulation

Additional Keywords : BLACK TEA, Diabetes mellitus: Type 2, Hypoglycemic Agents, Hypolipidemic, Inflammation, Plant Extracts

[+]

The results concluded that inflammation as a major cause of hypertension was significantly decreased in patients using olive leaf extract tablets.Dec 31, 2018

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Pubmed Data : J Ethnopharmacol. 2019 Nov 7:112325. Epub 2019 Nov 7. PMID: 31707049

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Pubmed Data : Inflammation. 2015 Dec 11. Epub 2015 Dec 11. PMID: 26658749

Article Published Date : Dec 10, 2015

Study Type : Human In Vitro

Additional Links

Substances : Citral

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Curcumin may offer a viable alternative for the prevention or control of HIV replication in the female genital tract.Dec 31, 2014

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[+]

Anethole ameliorates inflammation induced by monosodium urate in an acute gouty arthritis model.Dec 31, 2021

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Pubmed Data : Oncotarget. 2015 Oct 17. Epub 2015 Oct 17. PMID: 26506421

Article Published Date : Oct 16, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cardamonin

Diseases : Breast Cancer, Breast Cancer Stem Cells

Pharmacological Actions : Chemotherapeutic, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor

Additional Keywords : Chemotherapeutic Synergy: Doxorubicin, Drug Resistant Cancer Stem Cells

[+]

Celastrol alleviates chronic obstructive pulmonary disease by inhibiting cellular inflammation induced by cigarette smoke.Dec 31, 2017

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Effect of Psoralea corylifolia in treating fatty liver disease in juvenal mouse by inhibiting hepatic NF-κB activationJun 30, 2017

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Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2017 Jul ;42(13):2546-2551. PMID: 28840697

Article Published Date : Jun 30, 2017

Study Type : Animal Study

Additional Links

Substances : Babchi

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Effects of berberine on lipid metabolism, antioxidant status, and immune response in liver of tilapia under a high-fat diet feeding.Apr 28, 2024

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Pubmed Data : Int J Mol Sci. 2022 Aug 30 ;23(17). Epub 2022 Aug 30. PMID: 36077254

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Pubmed Data : Viruses. 2023 Mar 30 ;15(4). Epub 2023 Mar 30. PMID: 37112864

Article Published Date : Mar 29, 2023

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract

Diseases : Dengue

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Hydroxytyrosol alleviates methotrexate-induced pulmonary fibrosis in rats.Dec 31, 2023

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Pubmed Data : J Cell Physiol. 2018 Aug ;233(8):6291-6303. Epub 2018 Mar 9. PMID: 29521424

Article Published Date : Jul 31, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Carnosic Acid

Diseases : Arthritis, Neuropathic Pain

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Matrix metalloproteinase-3 (MMP-3) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Salvia miltiorrhiza ameliorates endometritis.Dec 31, 2023

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Pubmed Data : Front Pharmacol. 2024 ;15:1349139. Epub 2024 Apr 3. PMID: 38633614

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Endometritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation

[+]

Salvianolic acid A attenuates early brain injury after subarachnoid hemorrhage.Dec 31, 2016

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Pubmed Data : Bioengineered. 2021 Dec ;12(1):4349-4360. PMID: 34308769

Article Published Date : Nov 30, 2021

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Sweet olive extract attenuates dextran sulfate sodium-induced colitis in mice.Aug 27, 2018

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Pubmed Data : J Med Food. 2018 Aug 28. Epub 2018 Aug 28. PMID: 30153075

Article Published Date : Aug 27, 2018

Study Type : Animal Study

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Substances : Olive

Diseases : Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation

Additional Keywords : Plant Extracts

[+]

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Pubmed Data : Am J Chin Med. 2020 ;48(5):1121-1140. PMID: 32668966

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Yarrow

Diseases : Atopic Dermatitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

This is the first demonstration of the anti-inflammatory properties of CBD in an experimental model of allergic contact dermatitis.Apr 08, 2018

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Pubmed Data : Nutrients. 2020 Jun 18 ;12(6). Epub 2020 Jun 18. PMID: 32570937

Article Published Date : Jun 17, 2020

Study Type : Animal Study

Additional Links

Substances : Choline, Feverfew, Green Coffee Bean, Milk Thistle, Vitamin E: alpha tocopherol

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hepatoprotective, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : Phytother Res. 2020 May 30. Epub 2020 May 30. PMID: 32472655

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Pubmed Data : Molecules. 2020 Sep 23 ;25(19). Epub 2020 Sep 23. PMID: 32977636

Article Published Date : Sep 22, 2020

Study Type : In Vitro Study

Additional Links

Substances : Carrot

Diseases : Breast Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor

Additional Keywords : Cancer Stem Cells

[+]

A combination of LL-37 and polyphenols from cranberry and green tea acted in synergy to reduce the secretion of cytokines by an LPS-stimulated 3D co-culture model of oral mucosal cells.May 31, 2015

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Pubmed Data : Arch Oral Biol. 2015 Jun ;60(6):845-53. Epub 2015 Feb 27. PMID: 25791329

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cranberry Proanthocyanidins, EGCG (Epigallocatechin gallate)

Diseases : Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation

Additional Keywords : Natural Substance Synergy

[+]

A polar extract of Curcuma longa protects cartilage homeostasisJan 07, 2018

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Pubmed Data : Inflammopharmacology. 2018 Jan 8. Epub 2018 Jan 8. PMID: 29313174

Article Published Date : Jan 07, 2018

Study Type : In Vitro Study

Additional Links

Substances : Turmeric

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Interleukin-8 downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Pubmed Data : Biosci Biotechnol Biochem. 2020 May 24:1-11. Epub 2020 May 24. PMID: 32448093

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Pubmed Data : Sci Rep. 2021 04 22 ;11(1):8754. Epub 2021 Apr 22. PMID: 33888745

Article Published Date : Jan 21, 2021

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Pubmed Data : Int J Mol Sci. 2023 Jul 3 ;24(13). Epub 2023 Jul 3. PMID: 37446206

Article Published Date : Jul 02, 2023

Study Type : In Vitro Study

Additional Links

Substances : Hydroxytyrosol, Oleuropein, Polyphenols

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Antioxidant and anti-Inflammatory effects of thyme essential oils.Jul 05, 2022

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Pubmed Data : Antioxidants (Basel). 2022 Jul 6 ;11(7). Epub 2022 Jul 6. PMID: 35883820

Article Published Date : Jul 05, 2022

Study Type : In Vitro Study

Additional Links

Substances : Thyme

Diseases : Lipopolysaccharide-Induced Toxicity, Pseudomonas aeruginosa

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Essential Oils

[+]

Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3.Dec 31, 2018

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Pubmed Data : J Cell Biochem. 2018 Nov 28. Epub 2018 Nov 28. PMID: 30485517

Article Published Date : Nov 27, 2018

Study Type : In Vitro Study

Additional Links

Substances : Carvacrol

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

CBD differentially regulated basal pro-inflammatory response and attenuated both LPS-induced cytokine release and NF-κB activity in monocytes.Aug 18, 2019

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Pubmed Data : Toxicol Appl Pharmacol. 2019 Aug 19:114713. Epub 2019 Aug 19. PMID: 31437494

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Pubmed Data : J Dermatol Sci. 2017 May 27. Epub 2017 May 27. PMID: 28610718

Article Published Date : May 26, 2017

Study Type : In Vitro Study

Additional Links

Substances : Echinacea

Diseases : Eczema: Atopic

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation

[+]

Effect of sweet potato purple acid phosphatase on Pseudomonas aeruginosa flagellin-mediated inflammatory response in A549 cells.Jun 29, 2022

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Pubmed Data : Anim Biosci. 2022 Jun 30. Epub 2022 Jun 30. PMID: 35798038

Article Published Date : Jun 29, 2022

Study Type : In Vitro Study

Additional Links

Substances : Sweet Potato: Purple

Diseases : Pseudomonas aeruginosa

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation

[+]

Effects of Sulforaphane on SARS‑CoV‑2 infection and NF‑κB dependent expression of genes involved in the COVID‑19 cytokine storm.Aug 31, 2023

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Pubmed Data : Int J Mol Med. 2023 Sep ;52(3). Epub 2023 Jul 21. PMID: 37477130

Article Published Date : Aug 31, 2023

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Coronavirus Infection

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor

Additional Keywords : Cytokine Storm

[+]

Effects of two polysaccharides from Lepidium meyenii (maca) on intestinal immunity and inflammation in vitro.Mar 20, 2022

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Pubmed Data : Food Funct. 2022 Mar 21 ;13(6):3441-3452. Epub 2022 Mar 21. PMID: 35244109

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Pubmed Data : Cell Physiol Biochem. 2018 ;46(5):2072-2081. Epub 2018 Apr 28. PMID: 29723847

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Pubmed Data : Biomed Pharmacother. 2016 Dec ;84:1282-1290. Epub 2016 Oct 28. PMID: 27810785

Article Published Date : Nov 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Gallic Acid

Diseases : Liver Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Interleukin-10 upregulation, Interleukin-12 upregulation, Interleukin-8 downregulation

[+]

Galuteolin suppresses proliferation and inflammation in TNF-α-induced RA-FLS cells.Oct 20, 2020

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Pubmed Data : Int Immunopharmacol. 2018 Sep ;62:86-95. Epub 2018 Jul 5. PMID: 29990698

Article Published Date : Aug 31, 2018

Study Type : In Vitro Study

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Substances : Genistein

Diseases : Melanoma

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Interleukin-8 downregulation, Postaglandin PGE2 downregulation

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Ginger extract may be developed as a functional food for the maintenance of gastrointestinal health.Mar 28, 2017

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Pubmed Data : J Food Sci. 2017 Mar 29. Epub 2017 Mar 29. PMID: 28369951

Grape seed proanthocyanidin extract helps to prevent respiratory syncytial virus induced airway disease.Mar 31, 2019

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Pubmed Data : Mol Med Rep. 2019 Apr ;19(4):3330-3336. Epub 2019 Feb 19. PMID: 30816467

Article Published Date : Mar 31, 2019

Study Type : In Vitro Study

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Substances : Grape Seed Extract

Diseases : Respiratory Syncytial Virus Infections

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation

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Green and black tea extracts are capable of disrupting the molecular link between inflammation and carcinogenesis.Sep 30, 2010

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Pubmed Data : Planta Med. 2010 Oct ;76(15):1659-65. Epub 2010 May 26. PMID: 20506079

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Highbush blueberry proanthocyanidins alleviate Porphyromonas gingivalis-induced deleterious effects on oral mucosal cells.Aug 28, 2020

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Pubmed Data : Anaerobe. 2020 Aug 29 ;65:102266. Epub 2020 Aug 29. PMID: 32871243

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Pubmed Data : Mol Cell Biochem. 2019 Mar ;453(1-2):179-186. Epub 2018 Oct 22. PMID: 30350306

Article Published Date : Feb 28, 2019

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Respiratory Infections: Infants & Children

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Icariin negatively regulated lipopolysaccharide-induced inflammation and ameliorated the odontogenic activity of human dental pulp cells.Nov 30, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2020 Nov 18. Epub 2020 Nov 18. PMID: 33220376

Article Published Date : Nov 17, 2020

Study Type : In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Skin Diseases: Inflammatory

Pharmacological Actions : Anti-Inflammatory Agents, interleukin-13 down-regulation, Interleukin-1 beta downregulation, Interleukin-5 downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Luteolin as a modulator of skin aging and inflammation.Feb 28, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biofactors. 2021 Mar ;47(2):170-180. Epub 2020 Dec 25. PMID: 33368702

Article Published Date : Feb 28, 2021

Study Type : Review

Additional Links

Substances : Luteolin

Diseases : Aging Skin, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-17 downregulation, Interleukin-1 beta downregulation, Interleukin-22 Downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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View the Evidence: 402 Abstracts with Interleukin-8 downregulation Research

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Anti-inflammatory and antioxidant activity of ursolic acidDec 31, 2022

Resveratrol for inflammatory bowel disease in preclinical studies.Dec 31, 2023

CoQ10 supplementation reduced some of the important markers of inflammation and MMPs in patients with breast cancer.May 31, 2021

A mindfulness-based stress reduction program might have beneficial effects on early stages of wound healing.May 31, 2018

A single 20 min session of yogic breathing practice could reduce the levels of key pro-inflammatory biomarkers in saliva.Aug 17, 2016

A single vitamin D3 bolus supplementation improves vitamin D status and reduces proinflammatory cytokines.Sep 23, 2022

An elemental diet reduces mucosal inflammation in patients with active Crohn's disease with remission occuring in 71% of patients. Jun 01, 2005

Anti-inflammatory effects of diet and caloric restriction in metabolic syndrome.Mar 07, 2021

Beneficial effects of probiotic combination with omega-3 fatty acids in NAFLD.Nov 30, 2018

Coenzyme Q10 supplementation could be effective in ameliorating inflammatory cytokine levels caused by breast cancer.Dec 31, 2018

Consumption of kefir made with traditional microorganisms resulted in greater improvements in LDL cholesterol and plasma markers of inflammation.May 23, 2023

CoQ10 intake for 12 weeks in PCOS women significantly improved gene expression of LDLR, PPAR-γ, IL-1, IL-8 and TNF-α.Sep 25, 2017

Curcumin could be used for improving nasal airflow and modulating immune response in patients with allergic rhinitis.Nov 30, 2016

Effect of berberine hydrochloride on the diversity of intestinal flora in Parkinson's disease patients.Dec 31, 2021

Effect of butylphthalide on serum CRP, PARK7, NT-3 and neurological function in patients with acute cerebral infarction.Dec 31, 2020

Effects of oligo-fucoidan on the immune response, inflammatory status and pulmonary function in patients with asthma.Oct 27, 2022

Effects of Pelargonium sidoides extract vs roxithromycin on chemokine levels in nasal secretions of patients with uncomplicated acute rhinosinusitis.Jan 31, 2021

Effects of standardized Brazilian green propolis extract on inflammation in haemodialysis patients.Dec 31, 2021

Electroacupuncture ameliorates knee osteoarthritis.Aug 11, 2024

Fermented Carica papaya and Morinda citrifolia as perspective food supplements for the treatment of post-COVID symptoms.May 24, 2022

Fisetin could improve the inflammatory status in colorectal cancer patients.Mar 14, 2018

Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids.Nov 30, 2019

Ginkgo is effective in treating pulmonary interstitial fibrosis.Mar 01, 2005

Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis.Mar 26, 2023

Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19.Dec 31, 2020

L. plantarum PS128 may be a potential ergogenic aid for better training management, physiological adaptations to exercise, and health promotion.Feb 06, 2019

Lactobacillus acidophilus modulates inflammatory activity by regulating the TLR4 and NF-κB expression in porcine peripheral blood mononuclear cells.Feb 27, 2016

Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation.Feb 16, 2021

Lactobacillus-fermented Chamaecyparis obtusa treatment was rapid and effective for treating acne lesions compared to tea tree oil.Dec 31, 2013

Levagen+ can alleviate allergic rhinitis symptoms, resulting in a reduction in histamine and inflammatory markers.Nov 27, 2023

Low level light effects on inflammatory cytokine production by rheumatoid arthritis synoviocytes.Mar 31, 2009

Mango polyphenols reduce IL-8, GRO, and GM-SCF plasma levels and increase lactobacillus species in patients with inflammatory bowel disease. Dec 31, 2019

Micronized palmitoylethanolamide, hempseed oil, and maritime pine bark dry extract for pelvic pain.Feb 13, 2023

Oat porridge consumption alleviates markers of inflammation and oxidative stress in hypercholesterolemic adults.Dec 31, 2018

Omega-3 fatty acid supplementation reduces inflammatory biomarkers, erythrocyte sedimentation rate, and interleukin-8 concentrations in cystic fibrosis patients.May 01, 2010

Oral administration of tannase-treated green tea extract containing antioxidants without concomitant exercise can improve muscle mass and strength.Jun 24, 2021

Oral supplementation with pressurized whey improves nutritional status and can have additional beneficial effects on inflammation in patients with cystic fibrosis.Feb 01, 2010

PBM may accelerate wound healing by stimulating production of selected mediators. May 31, 2016

PBMt is effective in decreasing pain intensity and post-surgery inflammation in patients receiving total hip arthroplasty.Nov 30, 2018

Photobiomodulation improves serum cytokine response in mild to moderate COVID-19.Dec 31, 2021

Phyllanthus emblica fruit extract alleviates halitosis and reduces the inflammatory response to oral bacteria.Dec 31, 2023

Probiotic supplementation for 12 weeks in patients with multiple sclerosis significantly improved gene expression of IL-8 and TNF-α.Oct 31, 2017

Punicalagin might be one of natural therapeutic compounds for relieving rheumatoid arthritis progression.Dec 31, 2020

Quercetin significantly improves antioxidant status of patients with sarcoidosis.Nov 14, 2008

Role of ascorbic acid infusion in critically ill patients with transfusion-related acute lung injury.Dec 04, 2021

Salvia miltiorrhiza mitigates severe acute pancreatitis.Jan 01, 2007

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Silymarin has anti-inflammatory activity superior to the drugs piroxicam and meloxicam in the treatment of osteoarthritis of the knee. Mar 10, 2010

Successful therapy of Clostridium difficile infection with fecal microbiota transplantation.Nov 30, 2016

The 3-year effect of the mediterranean diet intervention on inflammatory biomarkers related to cardiovascular disease.Jul 21, 2021

The administration of vitamin B 6 in the treatment of patients with sepsis attenuates renal injury,May 31, 2024

The effect of two-month treatment with Zataria multiflora on inflammatory cytokines, pulmonary function testes and respiratory symptoms in patients with chronic obstructive pulmonary disease.Jul 14, 2022

The present study provides evidence that Diabetea tea has hypoglycemic and antihyperlipidemic properties.Dec 23, 2016

The results concluded that inflammation as a major cause of hypertension was significantly decreased in patients using olive leaf extract tablets.Dec 31, 2018

These data strongly suggest that probiotics may down modulate key parameters of allergic rhinitis.Mar 31, 2011

This study contributes important insights into the potential benefits and mechanisms of tai chi.Aug 24, 2015

Vitamin D supplementation may contribute to reduced inflammation and improved lung function in cystic fibrosis.Dec 13, 2016

Z. multiflora reduced inflammation and improved pulmonary function tests indices in sulfur mustard-exposed patients.Nov 06, 2019

Zinc supplementation is associated with clinical and laboratory improvement in cases of neonatal respiratory distress syndrome.Dec 31, 2020

Antiviral and immunomodulatory effects of Pelargonium sidoides DC. root extract EPs® 7630 in SARS-CoV-2-infected human lung cells.Dec 31, 2020

Citral inhibits LPS-induced inflammatory response via activating PPAR-γ which attenuates NF-κB activation.Dec 10, 2015

Curcumin may offer a viable alternative for the prevention or control of HIV replication in the female genital tract.Dec 31, 2014

Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.Dec 12, 2019

Neferine exerts a cytoprotective effect against hypoxia-induced oxidative stress and inflammation in human peripheral blood mononuclear cells.Jul 08, 2017

Niacinamide mitigates SASP-related inflammation induced by environmental stressors in human epidermal keratinocytes and skin.Sep 30, 2020

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Punicalagin and EGCG can rescue keratinocyte viability and attenuate the inflammatory responses of cells due to airborne particles.Mar 21, 2018

Rosmarinic acid may be a potential candidate for the treatment of psoriasis.Jun 14, 2016

Bromelain extract exerts antiarthritic effects via chondroprotection.Oct 22, 2021

Korean Red Ginseng water extract inhibits cadmium-induced lung injury.Aug 31, 2022

Pomegranate extract affects gut biofilm forming bacteria and promotes intestinal mucosal healing.Apr 04, 2023

Terminalia chebula extract ameliorates the symptoms of atopic dermatitis.Jul 03, 2022

Interleukin-8 downregulation

View the Evidence:
402 Abstracts with Interleukin-8 downregulation Research