Matrix metalloproteinase-1 MMP-1 inhibitor

Name	AC	CK
Flavonoids	10	12
Aloe Vera	1	10
Punicalagin	1	10
Rutin	1	10
Sesamin	2	7
Ginsenosides	2	6
Oleuropein	2	6
Ginseng	1	5
Apigenin	2	4
Astaxanthin	2	3
Curcumin	2	3
Fucoidan	2	3
Kaempferol	2	3
Polyphenols	2	3
Rose	2	3
Sea buckthorn	2	3
Acai	1	2
Antrodia Camphorate	1	2
Berberine	2	2
Chaga Mushroom (Inonotus obliquus)	1	2
Ferulic acid	1	2
Garlic	1	2
Hawthorn	1	2
Isoliquiritigenin	1	2
Lactobacillus rhamnosus GG	1	2
Orthosiphon	1	2
Phellinus Linteus	1	2
Porridge	1	2
Urolithin A	2	2
Arnica	1	1
Asiatic Acid	1	1
Baicalein	1	1
Betulinic acid	1	1
Black Currant	1	1
Blackberry	1	1
Butterfly Pea	1	1
Caffeic acid phenethyl ester	1	1
Cannabidiol	1	1
Cannabinoids	1	1
Cannabis	1	1
Carotenoids	1	1
Catechin	1	1
Dandelion	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Fenugreek	1	1
Fisetin	1	1
Flowers	1	1
Genipin	1	1
Guduchi	1	1
Honeysuckle	1	1
Hops	1	1
Lactoferrin	1	1
Lignans	1	1
Lotus	1	1
Lupeol	1	1
Melatonin	1	1
Myricetin	1	1
Nettle	1	1
Oridonin	1	1
Palash	1	1
Passion fruit	1	1
Peony	1	1
Persimmon	1	1
Piceatannol	1	1
Prickly Pear Cactus	1	1
Puerarin	1	1
Red Clover	1	1
Reishi Mushroom	1	1
Rosemary	1	1
Seaweed: Brown	1	1
Sesame Seeds	1	1
Shitake Mushroom	1	1
Silibinin	1	1
Terminalia chebula	1	1
Tomato	1	1
Wogonin	1	1

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Apigenin can regulate the gene expression, secretion, and activity of MMP-3, by directly acting on articular chondrocytes.Feb 29, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Agric Food Chem. 2018 Aug 15 ;66(32):8537-8546. Epub 2018 Jul 31. PMID: 30032605

Pubmed Data : Int Immunopharmacol. 2014 Mar ;19(1):174-7. Epub 2014 Jan 27. PMID: 24480614

Article Published Date : Feb 28, 2014

Study Type : In Vitro Study

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Substances : Astaxanthin

Diseases : Osteoarthritis

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Pubmed Data : J Oncol. 2022 ;2022:2841762. Epub 2022 Sep 13. PMID: 36147444

Article Published Date : Dec 31, 2021

Study Type : In Vitro Study

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Substances : Kaempferol

Diseases : Colon Cancer

Pharmacological Actions : Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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EGCH inhibits UVB irradiation associated changes associated with aging in human skin cells. Apr 01, 2008

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Pubmed Data : Food Chem Toxicol. 2008 Apr;46(4):1298-307. Epub 2007 Dec 8. PMID: 18226437

Article Published Date : Apr 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Catechin

Diseases : Skin Diseases: Photo-Aging

Pharmacological Actions : Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix Metalloproteinase-8 Inhibitor

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Ethanolic fenugreek extract: its molecular mechanisms against skin aging.Feb 19, 2022

Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ethnopharmacol. 2013 Jul 9 ;148(2):537-43. Epub 2013 May 13. PMID: 23680157

Article Published Date : Jul 08, 2013

Study Type : In Vitro Study

Additional Links

Substances : Palash

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Plant Extracts

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These results suggest that sesamolin induces apoptosis in HCT116 cells.Jul 30, 2019

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Pubmed Data : Cell Mol Biol (Noisy-le-grand). 2019 Jul 31 ;65(6):96-100. Epub 2019 Jul 31. PMID: 31472054

Article Published Date : Jul 30, 2019

Study Type : In Vitro Study

Additional Links

Substances : Lignans, Sesame Seeds

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Interleukin-6 Downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor

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This review describes the multiple effects of fisetin with special emphasis on its anticancer activity as investigated in cell culture and animal models.Jul 09, 2013

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Pubmed Data : Antioxid Redox Signal. 2013 Jul 10 ;19(2):151-62. Epub 2012 Dec 18. PMID: 23121441

Article Published Date : Jul 09, 2013

Study Type : Review

Additional Links

Substances : Fisetin, Flavonoids

Diseases : Cancers: All, Colon Cancer, Lung Cancer, Malignant Melanoma, Pancreatic Cancer, Prostate Cancer

Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative , Chemopreventive, Matrix metalloproteinase-1 (MMP-1) inhibitor, Neuroprotective Agents

Additional Keywords : Dietary Flavanoid

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This study demonstrates that combination of dietary carotenoids and polyphenols synergistically inhibit UV-induced skin cell damage.May 31, 2019

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View the Evidence: 88 Abstracts with Matrix metalloproteinase-1 (MMP-1) inhibitor Research

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Aloe gel significantly improves wrinkles and elasticity in photoaged human skin.Feb 01, 2009

Biological effects of rutin on skin aging.Jun 30, 2016

Punicalagin might be one of natural therapeutic compounds for relieving rheumatoid arthritis progression.Dec 31, 2020

Ginsenoside 20(S)-Rh2 has therapeutic potential for the treatment with colorectal cancer.Dec 23, 2016

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes.Dec 12, 2016

Acacetin suppresses IL-1 β-induced expression of matrix metalloproteinases in chondrocytes and protects against osteoarthritis.Dec 31, 2019

Acai berry water extracts might have potential as a wound healing agents.Mar 31, 2017

Ameliorative effects of high intensity interval training and Lactobacillus rhamnosus GG Protect against tetracycline-induced fatty liver.Dec 31, 2021

Apigenin can regulate the gene expression, secretion, and activity of MMP-3, by directly acting on articular chondrocytes.Feb 29, 2016

Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo.Jun 05, 2016

Astaxanthin ameliorates cartilage damage in experimental osteoarthritis.Aug 31, 2015

Astragalin suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis.Dec 31, 2018

Curcumin suppresses type II collagen-induced arthritis in mice.Sep 01, 2009

Ergostatrien-3β-ol has significant beneficial antiinflammatory and antiphotoaging activities.Sep 09, 2016

Ferulic acid may be a potential therapy for osteoarthritis.Jun 01, 2021

Garlic may be effective for preventing skin photoaging accelerated by UV irradiation through the antioxidative system and MMP regulation.Dec 31, 2015

Hawthorn polyphenol extract inhibits UVB-induced skin photoaging.Aug 14, 2018

I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senescence.Apr 30, 2011

Java Tea (Orthosiphon stamineus) protected against osteoarthritis.Jul 31, 2018

Kaempferol may be useful in decreasing alveolar bone resorption, attachment loss and MMP-1 and -8 production in experimental periodontitis.Mar 31, 2016

Phellinus linteus mycelium has a strong chondroprotective effect through the suppression both ROS production and inflammation.Dec 31, 2019

Rice porridge containing Welsh onion root water extract is effective in treating osteoarthritis symptoms.Jun 29, 2019

Sea buckthorn has potential as a protective and therapeutic treatment candidate against skin aging.Jul 31, 2012

Sesamin has potential for use as a skin protection agent in antiphotodamage and skin care products.Sep 11, 2019

These results suggest a potential therapeutic role of isoliquiritigenin to treat osteoarthritis.Jun 14, 2018

These results suggest that administration of fucoidan prevents the progression of osteoarthritis in a MIA-induced OA rats.Jul 20, 2015

Total saponins from Rosa laevigata can be applied as one effective candidate for the treatment of liver fibrosis.Jun 14, 2015

Oridonin inhibits IL-1β-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-γ.Mar 31, 2019

A standardized Terminalia chebula fruit extract alters the expression of genes associated with skin architecture and barrier formation.Oct 05, 2020

Acacetin inhibits expression of matrix metalloproteinases.Jul 31, 2015

Albiflorin inhibits advanced glycation end products-induced ROS and MMP-1 expression in gingival fibroblasts.Apr 26, 2024

Anti-migratory effects were confirmed for cannabinoid-treated lung cancer cell lines (H460 and H358).Sep 14, 2014

Arnica flower extracts exhibit anti-inflammatory properties.Oct 01, 2009

Asiatic acid inhibits osteosarcoma cell migration and invasionApr 02, 2024

Astaxanthin may be beneficial in the treatment of osteoarthritis.Feb 28, 2014

Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes.Mar 31, 2024

Berberine has potential as an anti-metastatic agent in melanoma.Aug 12, 2018

Berberine inhibits RA-FLS cell proliferation and adhesion by regulating RAS/MAPK/FOXO/HIF-1 signal pathway in the treatment of rheumatoid arthritis.Jan 31, 2023

Betulinic acid inhibits endometriosis through specific suppression of the ERβ signalling pathway.Dec 31, 2019

Black currants are a suitable target for further investigation as an anti-photoaging agent.May 15, 2018

Blackberry leaf extract contains phytonutrients that prevent wrinkle formation.Oct 01, 2007

Caffeic acid phenethyl ester maybe a promising agent for the prevention of skin photoaging via targeting histone acetyltransferase.Jun 21, 2019

Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.Apr 01, 2010

Chondroprotective effect of cynaroside in IL-1 β-induced primary rat chondrocytes and organ explants.Dec 31, 2019

Curcumin might provide a novel therapeutic strategy for treating gliomas.Nov 18, 2005

Diospyros kaki leaves inhibit HGF/Met signaling-mediated EMT and stemness features in hepatocellular carcinoma.Jul 31, 2020

Effect of kaempferol on the biological behavior of human colon cancer via regulating MMP1, MMP2, and MMP9.Dec 31, 2021

EGCH inhibits UVB irradiation associated changes associated with aging in human skin cells. Apr 01, 2008

Ethanolic fenugreek extract: its molecular mechanisms against skin aging.Feb 19, 2022

Galuteolin suppresses proliferation and inflammation in TNF-α-induced RA-FLS cells.Oct 20, 2020

Ganoderma polysaccharides treatment may serve as a novel strategy for antiphotoaging.Dec 31, 2016

Genipin could be used for the treatment of periodontal disease to prevent MMPs expression in periodontal lesion.Nov 30, 2014

Glycosyl flavones from Humulus japonicus suppress MMP-1 production via decreasing oxidative stress in UVB irradiated human dermal fibroblasts. Apr 21, 2020

Hyperoside reduced particulate matter 2.5-induced endoplasmic reticulum stress and senescence in skin cells.Jun 05, 2024

Isoorientin alleviates UVB-induced skin injury by regulating mitochondrial ROS and cellular autophagy.Jan 04, 2019

Lentinan inhibits AGE-induced inflammation and the expression of matrix-degrading enzymes in human chondrocytes.Dec 31, 2019

Low-molecular-weight fucoidan may have therapeutic potential in the treatment of rheumatoid arthritis.Sep 30, 2015

Lupeol may be useful as an anti-aging agent.Feb 28, 2019

Melatonin might inhibit soft tissue destruction by decreasing MMP-1 production in periodontal lesions.Jun 05, 2016

Molecular mechanisms of inhibitory effects of bovine lactoferrin on invasion of oral squamous cell carcinoma.Feb 06, 2023

Myricitrin inhibits fibroblast-like synoviocyte-mediated rheumatoid synovial inflammation and joint destruction.Dec 31, 2021

Neferine has strong antioxidative and photoprotective properties.Dec 20, 2018

O. humifusa fruit water extract has a preventive effect against solar ultraviolet-induced skin damage via suppression of pathways triggered by ROS.Aug 23, 2018

piceatannol and passion fruit seed extract containing high amounts of piceatannol are potential anti-photoageing cosmetic ingredients.Dec 31, 2012

Potential application of an aqueous extract of Tinospora cordifolia in oral submucous fibrosis.Jun 17, 2021

Protective effects of silibinin on LPS-induced inflammation in human periodontal ligament cells.Dec 31, 2021

Puerarin reduces oxidative damage and photoaging caused by UVA radiation.Nov 08, 2022

Red clover extract has a chondroprotective effect on inflammation and may be a potential preventative agent for osteoarthritis progression.Dec 31, 2017

Red light interferes in UVA-induced photoaging of human skin fibroblast cells.Dec 31, 2013

Rosa rugosa extracts and their isolated compounds, rosarugosides A and D, have the potential to prevent and protect against aging and skin damageMay 01, 2024

Seabuckthorn pulp oil prevents ultraviolet-induced damage in human fibroblasts.May 24, 2024

Matrix metalloproteinase-1 (MMP-1) inhibitor

View the Evidence:
88 Abstracts with Matrix metalloproteinase-1 (MMP-1) inhibitor Research