Matrix metalloproteinase-2 MMP-2 inhibitor

Name	AC	CK
Curcumin	35	50
Ginsenosides	30	43
Flavonoids	19	23
Coenzyme Q10	1	20
EGCG (Epigallocatechin gallate)	7	18
Ginseng	4	18
Pomegranate	7	18
Berberine	13	17
Catechin	5	16
Fisetin	5	14
Genistein	4	14
Omega-3 Fatty Acids	3	14
Polyphenols	9	14
Isoflavones	3	13
DHA (Docosahexaenoic Acid)	2	12
Luteolin	8	12
Hesperidin	2	11
Lycopene	6	11
Quercetin	8	11
Red Sage	6	11
Sulforaphane	6	11
Corni Fructus	1	10
Eicosapentaenoic acid (EPA)	1	10
Melatonin	5	10
Olive	1	10
Purslane	1	10
Resveratrol	9	10
Selenium	1	10
Soy Protein	1	10
Torilus Fructus	1	10
Unspecified Species	1	10
Yoghurt	1	10
Baicalein	7	9
Ellagic Acid	6	9
Paeoniflorin	5	9
Biochanin A	5	8
Fucoidan	5	8
Ginkgo biloba	5	8
Shikonin	4	8
Tanshinone IIA	5	8
Anthocyanins	6	7
Grape	5	7
Mangiferin	5	7
Naringenin	7	7
Parthenolide	2	7
Pterostilbene	6	7
Aloe Vera	4	6
Apigenin	4	6
Chrysanthemum Indicum	2	6
Formononetin	5	6
Garlic	4	6
Nobiletin	4	6
Orange: Mandarin	2	6
Piperine	2	6
Salvia miltiorrhiza	4	6
Thymoquinone	4	6
Broccoli	1	5
Chrysin	4	5
Feverfew	1	5
Isoliquiritigenin	3	5
Ligustrazine	3	5
Silibinin	4	5
Watercress	1	5
Astragaloside	3	4
Benzyl isothiocyanate	4	4
Beta-Elemene	4	4
Bisdemethoxycurcumin	4	4
Cordyceps Militaris	3	4
Crocin	3	4
Fermented Foods and Beverages	2	4
Ginger	3	4
Green Tea	3	4
Guduchi	3	4
Isothiocyanates	4	4
Kaempferol	3	4
Punicalagin	4	4
Rhubarb	4	4
Rosmarinic acid	3	4
Soy	2	4
St. Johns Wort	3	4
Turmeric	3	4
Vitamin E	2	4
Zerumbone	3	4
Allicin	2	3
Avocado	2	3
Bee Propolis	2	3
Deguelin	3	3
Diosgenin	3	3
Gallic Acid	3	3
Huaier (Trametes robiniophila murr)	3	3
Lignans	2	3
Liquiritigenin	2	3
Lotus	3	3
Oridonin	3	3
Paeonol	2	3
Persimmon	3	3
Phlorotannins	3	3
Sinomenine	3	3
Tomato	2	3
Vitamin C	2	3
Apple	1	2
Apple Polyphenols	2	2
Artemisinin	1	2
Ashwagandha	2	2
Bee Venom	2	2
Berbamine	2	2
Black Pepper	1	2
Blueberry	1	2
Bufalin	2	2
Burdock	2	2
Caffeic acid phenethyl ester	1	2
Camptothecin	1	2
Cannabidiol	1	2
Cannabinoids	1	2
Carnosine	1	2
Carotenoids	1	2
Celastrol	2	2
Celery Oil	1	2
Chamomile	1	2
Chlorogenic Acid	2	2
Cucurbitacin B	2	2
D-Limonene	1	2
Daidzein	1	2
Dogwood	1	2
EPA (Eicosapentaenoic Acid)	1	2
Eggplant	2	2
Elecampane	2	2
Folic Acid	1	2
Frankincense	2	2
Gac	2	2
Geraniol	1	2
Gleditsia sinensis	1	2
Harmine	2	2
Herb Bennet	2	2
Hu Zhang (Polygonum cuspidatum)	1	2
Hydrogen Water	1	2
Kaempferia parviflora	1	2
Kefir	1	2
Lactobacillus paracasei	1	2
Lactobacillus rhamnosus GG	1	2
Lemon Peel	2	2
Lettuce	1	2
Licorice	2	2
Loquat Leaves	2	2
Lupeol	2	2
Magnolol	2	2
Manuka Honey	2	2
Mulberry	2	2
NAC (N-acetyl-L-cysteine)	2	2
Nettle	1	2
Noni	1	2
Oolong tea	1	2
Orange	1	2
Palm Oil	1	2
Phyllanthus amarus	2	2
Phyllanthus niruri (Stonebreaker)	2	2
Phyllanthus urinaria	2	2
Piceatannol	2	2
Probiotics	1	2
Red Yeast Rice	1	2
Riboflavin (Vitamin B-2)	1	2
Rice Bran	1	2
Rose	1	2
Rosemary	1	2
Safflower	2	2
Saffron	1	2
Saikosaponin	2	2
Schisandra	2	2
Sea Cucumber	1	2
Seaweed: Brown	2	2
Sesamin	2	2
Sesamol	1	2
Stevia	1	2
Terminalia chebula	2	2
Theaflavins	2	2
Thistle	2	2
Tomatidine	2	2
Triptolide	1	2
Unsaponifiables	1	2
Ursolic Acid	1	2
Velvet antler	1	2
Verbascoside	1	2
Vitamin K	1	2
strawbrries	1	2
6-Shogaol	1	1
Andrographis	1	1
Andrographolide	1	1
Antrodia camphorata	1	1
Arctigenin	1	1
Artesunate	1	1
Artichoke	1	1
Asiatic Acid	1	1
Bai Zhu	1	1
Beta-Caryophyllene	1	1
Black Tea	1	1
Blackberry	1	1
Butterfly Pea	1	1
Caffeic Acid	1	1
Cannabinoids: Synthetic	1	1
Capsaicin	1	1
Cardamonin	1	1
Catechols	1	1
Chaga Mushroom (Inonotus obliquus)	1	1
Chili pepper	1	1
Chokeberry	1	1
Cinnamaldehyde	1	1
Citrus Peel	1	1
Cocoa	1	1
Crocetin	1	1
Cucurbitacin E	1	1
Curcuma phaeocaulis	1	1
Curcumol	1	1
Dandelion	1	1
Delphinidin	1	1
Demethoxycurcumin	1	1
Echinacea	1	1
Elm tree	1	1
Emodin	1	1
Enterolactone	1	1
Eugenol	1	1
False Black Pepper	1	1
Fenugreek	1	1
Ferulic acid	1	1
Garcinia Mangostana	1	1
Genipin	1	1
Geum japonicum	1	1
Ginseng (Siberian)	1	1
Glycyrrhizin	1	1
Grape Seed Extract	1	1
Gynostemma	1	1
Hawthorn	1	1
Holy Basil	1	1
Honokiol	1	1
Hops	1	1
Hydrangea	1	1
Hydroxytyrosol	1	1
Isothiocyanate	1	1
Jujube	1	1
Juniper	1	1
Kahweol	1	1
Lithospermum erythrorhizon	1	1
Lysine	1	1
Mangosteen	1	1
Marigold	1	1
Marjoram	1	1
Myricetin	1	1
Neem	1	1
Nexrutine (Phellodendrom)	1	1
Nisin	1	1
Oak	1	1
Oleuropein	1	1
Olive leaf extract	1	1
Onion	1	1
Organosulfur Compounds	1	1
Oyster Mushroom	1	1
Palash	1	1
Panax Notoginseng	1	1
Passion Flower	1	1
Patchouli	1	1
Peach	1	1
Phellinus Linteus	1	1
Phenethyl isothiocyanate	1	1
Phloretin	1	1
Piperlongumine	1	1
Plantago	1	1
Pomegranate Peel	1	1
Poria cocos	1	1
Prunella vulgaris	1	1
Psychedelics:All	1	1
Puerarin	1	1
Pycnogenol (Pine Bark)	1	1
Raspberry	1	1
Reishi Mushroom	1	1
Rice: Black	1	1
Rosemaric Acid	1	1
Sesame Seeds	1	1
Soursop	1	1
Soybean: Black	1	1
Syrian rue	1	1
Terminalia	1	1
Terminalia Chebula Gall Extract	1	1
Tocotrienol: Gamma	1	1
Toona sinensis	1	1
Traditional Chinese Medicine: Mylabris	1	1
Tyrosol	1	1
Urolithin A	1	1
Vitamin A	1	1
Wheat Grass	1	1
Wogonin	1	1
Xanthohumol	1	1

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Pubmed Data : J Med Food. 2009 Dec;12(6):1252-9. PMID: 20041778

Article Published Date : Dec 01, 2009

Study Type : Human Study

Additional Links

Substances : Corni Fructus, Ginseng, Torilus Fructus, Unspecified Species

Diseases : Aging Skin

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Plant Extracts

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Regular probiotic yoghurt consumption guarded against exhaustive exercise-inducing oxidative injury in young healthy females.Nov 30, 2018

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Pubmed Data : J Pak Med Assoc. 2018 Dec ;68(12):1748-1754. PMID: 30504936

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Pubmed Data : Am J Cardiol. 2008 Jul 1;102(1):84-6. Epub 2008 Apr 16. PMID: 18572041

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Substances : Isoflavones, Soy Protein

Diseases : C-Reactive Protein, Hypertension, Inflammation

Pharmacological Actions : Interleukin-6 Downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Cell Adhesion Molecule-1 Inhibitor

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This study showed a clinically relevant decrease in MMP-2 activity in patients with migraine treated with acupuncture.Sep 30, 2014

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Pubmed Data : Acupunct Med. 2014 Oct ;32(5):376-80. Epub 2014 Aug 27. PMID: 25164776

Article Published Date : Sep 30, 2014

Study Type : Human Study

Additional Links

Diseases : Headache: Migraine

Therapeutic Actions : Acupuncture

Pharmacological Actions : Analgesics, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Significant Treatment Outcome

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Ginsenoside 20(S)-Rh2 has therapeutic potential for the treatment with colorectal cancer.Dec 23, 2016

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Pubmed Data : J Ethnopharmacol. 2016 Dec 24 ;194:83-90. Epub 2016 Aug 23. PMID: 27566200

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Pubmed Data : EXCLI J. 2022 ;21:991-1006. Epub 2022 Jul 21. PMID: 36110559

Article Published Date : Dec 31, 2021

Study Type : Animal Study

Additional Links

Substances : Lactobacillus rhamnosus GG

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Exercise

Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor

Additional Keywords : Gene Expression Regulation

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Anthocyanins derived from Vitis coignetiae Pulliat contributes anti-cancer effects in Hep3B human hepatocellular carcinoma cells.Nov 19, 2020

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Pubmed Data : Anticancer Res. 2017 02 ;37(2):465-473. PMID: 28179291

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Pubmed Data : Life Sci. 2016 Jan 15 ;145:213-23. Epub 2015 Dec 17. PMID: 26706290

Article Published Date : Jan 14, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Baicalein

Diseases : Heart Failure

Pharmacological Actions : Anti-Apoptotic, Cardioprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Berberine as a promising natural compound for the treatment of periodontal disease.Oct 29, 2021

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Crocin's role in modulating MMP2/TIMP1 and mitigating hypoxia-induced pulmonary hypertension in mice.Jun 02, 2024

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Pubmed Data : Sci Rep. 2024 Jun 3 ;14(1):12716. Epub 2024 Jun 3. PMID: 38830933

Article Published Date : Jun 02, 2024

Study Type : Animal Study

Additional Links

Substances : Crocin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Transforming growth factor beta (TGF-β) inhibitor

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Cryptotanshinone could be developed as a potential therapeutic agent for the treatment of chronic diabetic wound healing.Nov 30, 2020

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Pubmed Data : J Biol Chem. 2005 Mar 11;280(10):9409-15. Epub 2004 Dec 22. PMID: 15615723

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Pubmed Data : Mol Med Rep. 2016 Jul ;14(1):955-62. Epub 2016 May 18. PMID: 27222119

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Daidzein, Isoflavones

Diseases : Aneurysm: Aortic

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Dietary intake of EPA and DHA prevented abdominal aortic aneurysm development.Dec 31, 2014

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Pubmed Data : Oncol Rep. 2017 Feb ;37(2):1084-1092. Epub 2016 Dec 22. PMID: 28035411

Article Published Date : Jan 31, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ellagic Acid

Diseases : Glioblastoma

Pharmacological Actions : Antiproliferative , Bcl-2 protein down-regulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.Jan 31, 2016

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Pubmed Data : Nutrients. 2023 Feb 23 ;15(5). Epub 2023 Feb 23. PMID: 36904105

Article Published Date : Feb 22, 2023

Study Type : Animal Study

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Substances : Fermented Foods and Beverages, Lettuce

Diseases : Arthritis, Rheumatoid Arthritis

Pharmacological Actions : Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Plant Extracts

[+]

Folic acid modulates matrix metalloproteinase-9 expression following spinal cord injury.Mar 31, 2019

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Pubmed Data : Ann Neurosci. 2019 Apr ;26(2):60-65. Epub 2019 Apr 1. PMID: 31975775

Article Published Date : Mar 31, 2019

Study Type : Animal Study

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Substances : Folic Acid

Diseases : Spinal Cord Injuries

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Pubmed Data : Biomed Pharmacother. 2018 Jun ;102:510-516. Epub 2018 Mar 24. PMID: 29579712

Article Published Date : May 31, 2018

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba

Diseases : Atherosclerosis

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Nitric Oxide Inhibitor

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Ginkgo biloba extract inhibits metastasis and in gastric cancer.Sep 10, 2019

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Pharmacological Actions : Anti-metastatic, Chemotherapeutic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

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Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma.Dec 31, 2015

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Pubmed Data : Sci Rep. 2016 ;6:21731. Epub 2016 Feb 25. PMID: 26911838

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Cancer Metastasis, Melanoma

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, STAT3 Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in mice.Jan 31, 2017

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Pubmed Data : Bioorg Med Chem. 2017 Feb 1 ;25(3):1057-1065. Epub 2016 Dec 18. PMID: 28031152

Article Published Date : Jan 31, 2017

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Pubmed Data : Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30. PMID: 16934674

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Pubmed Data : Biosci Biotechnol Biochem. 2016 Apr 4:1-9. Epub 2016 Apr 4. PMID: 27045316

Article Published Date : Apr 03, 2016

Study Type : Animal Study

Additional Links

Substances : Aloe Vera

Diseases : Ultraviolet Radiation Induced Damage

Pharmacological Actions : Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Photoprotective

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Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.Mar 31, 2012

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Pubmed Data : Biol Pharm Bull. 2009 Jul ;32(7):1142-7. PMID: 19571375

Article Published Date : Jun 30, 2009

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Cancers: All

Pharmacological Actions : Anti-Angiogenic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

[+]

Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells.Oct 30, 2013

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Pubmed Data : Indian J Pharmacol. 2022 May-Jun;54(3):198-207. PMID: 35848691

Pubmed Data : Prostate. 2019 Mar 19. Epub 2019 Mar 19. PMID: 30889629

Article Published Date : Mar 18, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Sea Cucumber

Diseases : Prostate Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights.Dec 31, 2017

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Pubmed Data : Redox Biol. 2018 06 ;16:169-178. Epub 2018 Mar 1. PMID: 29505920

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Pubmed Data : Nutr Cancer. 2015 Nov-Dec;67(8):1268-75. Epub 2015 Oct 16. PMID: 26474105

Article Published Date : Oct 31, 2015

Study Type : Animal Study

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Substances : Lycopene, Tomato

Diseases : Liver Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Anti-metastatic, Anticarcinogenic Agents, Chemopreventive, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Vascular Endothelial Growth Factor Inhibitors

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Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer.Aug 01, 2010

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Pubmed Data : Mol Cancer Ther. 2010 Aug;9(8):2255-64. Epub 2010 Jul 20. PMID: 20647339

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Pubmed Data : Photodermatol Photoimmunol Photomed. 2016 Dec 20. Epub 2016 Dec 20. PMID: 27995657

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Pubmed Data : Oxid Med Cell Longev. 2023 ;2023:6144967. Epub 2023 Jan 5. PMID: 36644578

Article Published Date : Dec 31, 2022

Study Type : Animal Study

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Substances : Polyphenols, Pomegranate

Diseases : Chronic Kidney Disease (CKD), Metabolic Syndrome X, Oxidative Stress

Pharmacological Actions : Antioxidants, Matrix metalloproteinase-2 (MMP-2) inhibitor, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

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This study demonstrated tanshinone IIA suppressed the progression of atherosclerosis.Apr 14, 2017

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Pubmed Data : Oncotarget. 2016 Jan 12 ;7(2):1544-58. PMID: 26637807

Article Published Date : Jan 11, 2016

Study Type : Animal Study, In Vitro Study

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Substances : Zerumbone

Diseases : Breast Cancer: Triple Negative , Cancer Metastasis

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Zingerone suppresses angiogenesis via inhibition of matrix metalloproteinases during tumor development.Jul 25, 2016

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Pubmed Data : Mol Biol Rep. 2019 Oct 30. Epub 2019 Oct 30. PMID: 31673889

Article Published Date : Oct 29, 2019

Study Type : In Vitro Study

Additional Links

Substances : Black Tea, Citrus Peel , Orange: Mandarin

Diseases : Liver Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Dose Response

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A hydroalcoholic extract of oak acorn shell acts as a potent antiangiogenic agent.Feb 28, 2013

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Pubmed Data : J Ethnopharmacol. 2023 Aug 10 ;312:116457. Epub 2023 Apr 21. PMID: 37088235

Article Published Date : Aug 09, 2023

Study Type : In Vitro Study

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Substances : Panax Notoginseng

Diseases : Cancers: All

Pharmacological Actions : Anti-Bacterial Agents, Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor

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Anti-inflammatory effect of luteoloside against methylglyoxal induced human dental pulp cells.Feb 29, 2024

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Pubmed Data : Polymers (Basel). 2024 May 3 ;16(9). Epub 2024 May 3. PMID: 38732748

Article Published Date : May 02, 2024

Study Type : In Vitro Study

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Substances : Persimmon

Diseases : Colon Cancer

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

Additional Keywords : Polysaccharides

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Anti-osteoarthritic effects of an herbal composition LI73014F2 on interleukin-1β-induced primary human articular chondrocytes. Apr 26, 2020

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Berberine hydrochloride inhibits cell proliferation and promotes apoptosis of non-small cell lung cancer.Apr 30, 2018

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Pubmed Data : Mol Biol Rep. 2020 Oct 19. Epub 2020 Oct 19. PMID: 33074411

Article Published Date : Oct 18, 2020

Study Type : In Vitro Study

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Substances : Berberine

Diseases : Osteosarcoma

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-2 (MMP-2) inhibitor

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Berberine suppresses tumorigenicity of triple negative breast cancer cells.Jan 30, 2018

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Pubmed Data : Cell Physiol Biochem. 2018 Jan 31 ;45(2):795-807. Epub 2018 Jan 31. PMID: 29414799

Article Published Date : Jan 30, 2018

Study Type : In Vitro Study

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Substances : Berberine

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor

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Beta-elemene inhibits tumor growth by downregulating the expression of uPA, uPAR, MMP-2, and MMP-9.Jan 31, 2015

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Pubmed Data : Melanoma Res. 2015 Feb ;25(1):15-21. PMID: 25405459

Article Published Date : Jan 31, 2015

Study Type : In Vitro Study

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Substances : Beta-Elemene

Diseases : Cancer Metastasis, Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor

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Beta-elemene reduces the malignancy of non-small cell lung cancer.Dec 31, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Oncol. 2021 ;11:571476. Epub 2021 May 7. PMID:

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View the Evidence: 580 Abstracts with Matrix metalloproteinase-2 (MMP-2) inhibitor Research

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CoQ10 supplementation reduced some of the important markers of inflammation and MMPs in patients with breast cancer.May 31, 2021

A vegetarian diet is associated with a healthier profile of cardiovascular biomarkers compared to omnivorous.Aug 01, 2016

Aerobic training and purslane seed ere effective in the regulation of diabetic biomarkers associated with atherosclerosis in women with T2D.Dec 04, 2016

EGCG has a protective effect against matrix metallopreinase in recessive dystrophic epidermolysis bullosa patients. Apr 01, 2007

Epigallocatechin gallate could potentially be used as a supplement of traditional rt-PA treatment among stroke patients.Dec 08, 2016

Fisetin prolongs therapy window of brain ischemic stroke using tissue plasminogen activator.Dec 31, 2018

Genistein may block metastasis and mortality in prostate cancer through blocking the activation of MEK4 and MMP-2 expression. Aug 19, 2009

Hesperidin reduces adverse symptomatic intracerebral hemorrhage.Sep 01, 2019

Olive oil inhibits ageing signs induced by chronic stress.Mar 31, 2019

Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis. Jul 01, 2009

Pomegranate juice significantly modulates matrix metalloproteinases 2 and 9 and serum levels of inflammatory factors protecting against exercise induced oxidative injury.Jun 30, 2014

Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin.Dec 01, 2009

Regular probiotic yoghurt consumption guarded against exhaustive exercise-inducing oxidative injury in young healthy females.Nov 30, 2018

Selenium supplementation among diabetic nephropathy patients had favourable effects on serum MMP-2, plasma NO, TAC and GSH.Sep 19, 2016

Slow-velocity eccentric-only resistance training improves symptoms of type 2 diabetic mellitus patients by regulating plasma MMP-2 and -9.Jul 18, 2024

The hypotensive and anti-inflammatory effect of soy nut consumption may be due to a reduction in solube vascular cell adhesion molecule-1 which results in an improvement in endothelial function. Jul 01, 2008

This study showed a clinically relevant decrease in MMP-2 activity in patients with migraine treated with acupuncture.Sep 30, 2014

Ginsenoside 20(S)-Rh2 has therapeutic potential for the treatment with colorectal cancer.Dec 23, 2016

Mandarin juice exerts in vitro antiproliferative effects on anaplastic thyroid carcinoma cells, associated with a reduction of migration.Sep 11, 2015

Parthenolide is a potential novel therapeutic agent for aggressive colorectal cancer treatment.Mar 31, 2017

Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.Dec 31, 2014

Shikonin and temozolomide may constitute a powerful new tool for Glioblastoma treatment by reducing therapy resistance and tumor recurrence.Apr 10, 2017

The addition of broccoli and watercress in the diet may reduce risk of breast cancerDec 01, 2005

Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoagingFeb 29, 2016

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

"Low molecular weight fucoidan prevents intimal hyperplasia in rat injured thoracic aorta through the modulation of matrix metalloproteinase-2 expression."Jan 14, 2011

A Chinese herbal formula containing Red Sage, Cordyceps and Peach kernel is superior to methylprednisone against experimental pulmonary fibrosis. May 01, 2007

A combination of Omega-3 fatty acids and vitamin E ameliorates or prevents vascular reactivity alterations in diabetes. Dec 01, 2009

A lipid-soluble ginseng extract potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner.Dec 31, 2014

A red yeast rice extract inhibits the proliferation of colorectal cancer cells.Mar 01, 2008

Allicin inhibits the proliferation and invasion in cholangiocarcinoma.May 21, 2018

Ameliorative effects of high intensity interval training and Lactobacillus rhamnosus GG Protect against tetracycline-induced fatty liver.Dec 31, 2021

Anthocyanins derived from Vitis coignetiae Pulliat contributes anti-cancer effects in Hep3B human hepatocellular carcinoma cells.Nov 19, 2020

Anti-obesity effect of rice bran extract on high-fat diet-induced obese mice. Jun 29, 2022

Anticancer effects of Gleditsia sinensis extract in rats transplanted with hepatocellular carcinoma cells.Aug 07, 2019

Antitumor activity of ginsenoside Rg3 in melanoma through downregulation of the ERK and Akt pathways.May 31, 2019

Apigenin protects against ovalbumin-induced asthma. Jul 01, 2009

Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells.Jan 14, 2011

Astragaloside IV and curcumin alone and in combination significantly reduced mean tumor weight compared to vehicle control.Dec 31, 2016

Attenuation of lipid metabolic abnormalities, proinflammatory cytokines, and matrix metalloproteinase expression by biochanin.Mar 14, 2021

Avocado/soybean unsaponifiables have a protective effect against experimental dog osteoarthritis. Jan 01, 2009

Baicalein alleviated myocardial remodelling and improved cardiac function.Jan 14, 2016

Berberine as a promising natural compound for the treatment of periodontal disease.Oct 29, 2021

Berberine attenuates experimental autoimmune encephalomyelitis in mice.Jan 01, 2010

Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway.Jul 22, 2018

Biochanin-A alleviates fibrosis and inflammation in cardiac injury.Jun 30, 2023

Blue LED irradiation inhibits cancer cell migration and invasion in vitro and in vivo.Jan 17, 2017

Blueberry inhibits the growth and metastatic potential of triple negative breast cancer in vitro and in vivo.May 01, 2010

Caffeic acid phenethyl ester may be a potential therapeutic agent for patients with advanced PCa.May 14, 2016

Camptothecin encapsulated with N-trimethyl chitosan exhibits anti-cancer properties in a preclinical mouse model of liver cancer.Nov 01, 2010

Cannabinoids inhibit the growth of gliomas in vivo by targeting both tumor cells and vascular endothelial cells.Feb 28, 2003

Carnosine protects against cerebral ischemic injury by inhibiting matrix-metalloproteinases.Jul 12, 2021

Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice.Nov 29, 2020

CBD can be used as a novel therapeutic option to inhibit growth and metastasis of highly aggressive breast cancer subtypes including TNBC.Mar 31, 2015

Chamomile and Nettle extract may be an effective supplement in improving the histological and immunological changes of PCOS.Apr 02, 2023

Chrysin attenuates interstitial fibrosis and improves cardiac function in a rat model of acute myocardial infarction.Sep 16, 2018

Components of Salvia miltiorrhiza Bunge, could inhibit the development of elastase-induced experimental abdominal aortic aneurysms.Nov 30, 2012

Cordyceps militaris fraction inhibits the invasion and metastasis of lung cancer cellsNov 30, 2018

Crocin's role in modulating MMP2/TIMP1 and mitigating hypoxia-induced pulmonary hypertension in mice.Jun 02, 2024

Cryptotanshinone could be developed as a potential therapeutic agent for the treatment of chronic diabetic wound healing.Nov 30, 2020

Curcumin improves left ventricular function in pressure overloaded rabbits. Feb 01, 2004

Curcumin inhibits prostate cancer tumors. Dec 01, 2009

Curcumin inhibits the growth of choroidal melanoma. Jan 15, 2011

Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts.Aug 01, 2010

Curcumin may have a beneficial effect in degenerative aortic aneurysms. May 01, 2006

Curcumin prevents human aortic smooth muscle cells migration associated with the development atherosclerosis.Feb 01, 2010

Curcumin protects against alcohol and oxidized fat-induced liver toxicity.Jul 01, 2004

Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model. Oct 15, 2005

Curcumin's antiulcer activity is primarily attributed to MMP-9 inhibition, one of the major path-ways of ulcer healing.Mar 11, 2005

Curcumin, when used as a complementary treatment to albendazole, could help to alleviate eosinophilic meningitis through suppression of eosinophil count in the cerebrospinal fluid.Feb 29, 2012

D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis.Mar 31, 2017

Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways.Jun 30, 2016

Matrix metalloproteinase-2 (MMP-2) inhibitor

View the Evidence:
580 Abstracts with Matrix metalloproteinase-2 (MMP-2) inhibitor Research