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Matrix metalloproteinase-2 (MMP-2) inhibitor
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238 Substances Researched for Matrix metalloproteinase-2 (MMP-2) inhibitor
Name
AC
CK
Focus
Curcumin
34
49
Ginsenosides
24
35
EGCG (Epigallocatechin gallate)
7
18
Ginseng
4
18
Catechin
5
16
Pomegranate
5
15
Genistein
4
14
Omega-3 Fatty Acids
3
14
Berberine
10
12
DHA (Docosahexaenoic Acid)
2
12
Fisetin
3
12
Flavonoids
9
12
Isoflavones
2
12
Hesperidin
2
11
Lycopene
6
11
Polyphenols
7
11
Red Sage
6
11
Sulforaphane
6
11
Corni Fructus
1
10
Eicosapentaenoic acid (EPA)
1
10
Melatonin
5
10
Purslane
1
10
Selenium
1
10
Soy Protein
1
10
Torilus Fructus
1
10
Unspecified Species
1
10
Yoghurt
1
10
Baicalein
7
9
Paeoniflorin
5
9
Fucoidan
5
8
Luteolin
5
8
Quercetin
6
8
Resveratrol
7
8
Anthocyanins
6
7
Grape
5
7
Parthenolide
2
7
Shikonin
3
7
Aloe Vera
4
6
Apigenin
4
6
Chrysanthemum Indicum
2
6
Formononetin
5
6
Naringenin
6
6
Nobiletin
4
6
Orange: Mandarin
2
6
Piperine
2
6
Tanshinone IIA
4
6
Biochanin A
3
5
Broccoli
1
5
Chrysin
4
5
Ellagic Acid
3
5
Feverfew
1
5
Isoliquiritigenin
3
5
Ligustrazine
3
5
Watercress
1
5
Astragaloside
3
4
Benzyl isothiocyanate
4
4
Ginger
3
4
Ginkgo biloba
2
4
Green Tea
3
4
Isothiocyanates
4
4
Pterostilbene
4
4
Rhubarb
4
4
Soy
2
4
Thymoquinone
3
4
Vitamin E
2
4
Allicin
2
3
Avocado
2
3
Bee Propolis
2
3
Deguelin
3
3
Garlic
2
3
Huaier (Trametes robiniophila murr)
3
3
Kaempferol
2
3
Liquiritigenin
2
3
Lotus
3
3
Oridonin
3
3
Paeonol
2
3
Punicalagin
3
3
Rosmarinic acid
2
3
Silibinin
3
3
St. Johns Wort
2
3
Tomato
2
3
Vitamin C
2
3
Zerumbone
2
3
Apple
1
2
Apple Polyphenols
2
2
Artemisinin
1
2
Ashwagandha
2
2
Beta-Elemene
2
2
Bisdemethoxycurcumin
2
2
Black Pepper
1
2
Blueberry
1
2
Bufalin
2
2
Burdock
2
2
Caffeic acid phenethyl ester
1
2
Camptothecin
1
2
Cannabidiol
1
2
Cannabinoids
1
2
Carotenoids
1
2
Cordyceps Militaris
1
2
Cucurbitacin B
2
2
D-Limonene
1
2
Daidzein
1
2
EPA (Eicosapentaenoic Acid)
1
2
Eggplant
2
2
Fermented Foods and Beverages
1
2
Folic Acid
1
2
Frankincense
2
2
Gac
2
2
Gallic Acid
2
2
Gleditsia sinensis
1
2
Hu Zhang (Polygonum cuspidatum)
1
2
Kaempferia parviflora
1
2
Lactobacillus paracasei
1
2
Licorice
2
2
Loquat Leaves
2
2
Lupeol
2
2
Magnolol
2
2
Mangiferin
2
2
Manuka Honey
2
2
Noni
1
2
Oolong tea
1
2
Orange
1
2
Palm Oil
1
2
Persimmon
2
2
Phyllanthus amarus
2
2
Phyllanthus niruri (Stonebreaker)
2
2
Phyllanthus urinaria
2
2
Probiotics
1
2
Red Yeast Rice
1
2
Riboflavin (Vitamin B-2)
1
2
Rose
1
2
Rosemary
1
2
Safflower
2
2
Saffron
1
2
Salvia miltiorrhiza
1
2
Schisandra
2
2
Sea Cucumber
1
2
Sesamin
2
2
Sesamol
1
2
Stevia
1
2
Terminalia chebula
2
2
Tomatidine
2
2
Triptolide
1
2
Unsaponifiables
1
2
Ursolic Acid
1
2
Verbascoside
1
2
Vitamin K
1
2
Andrographis
1
1
Antrodia camphorata
1
1
Arctigenin
1
1
Artesunate
1
1
Artichoke
1
1
Asiatic Acid
1
1
Bai Zhu
1
1
Bee Venom
1
1
Berbamine
1
1
Black Tea
1
1
Blackberry
1
1
Caffeic Acid
1
1
Cannabinoids: Synthetic
1
1
Capsaicin
1
1
Catechols
1
1
Celastrol
1
1
Chaga Mushroom (Inonotus obliquus)
1
1
Chili pepper
1
1
Chlorogenic Acid
1
1
Chokeberry
1
1
Citrus Peel
1
1
Cocoa
1
1
Crocin
1
1
Cucurbitacin E
1
1
Curcumol
1
1
Delphinidin
1
1
Diosgenin
1
1
Emodin
1
1
Enterolactone
1
1
False Black Pepper
1
1
Ferulic acid
1
1
Garcinia Mangostana
1
1
Genipin
1
1
Ginseng (Siberian)
1
1
Grape Seed Extract
1
1
Guduchi
1
1
Gynostemma
1
1
Holy Basil
1
1
Honokiol
1
1
Hydrangea
1
1
Hydroxytyrosol
1
1
Jujube
1
1
Juniper
1
1
Kahweol
1
1
Lemon Peel
1
1
Lignans
1
1
Lithospermum erythrorhizon
1
1
Lysine
1
1
Mangosteen
1
1
Marigold
1
1
Marjoram
1
1
Mulberry
1
1
Myricetin
1
1
NAC (N-acetyl-L-cysteine)
1
1
Nexrutine (Phellodendrom)
1
1
Oak
1
1
Oleuropein
1
1
Olive leaf extract
1
1
Palash
1
1
Passion Flower
1
1
Peach
1
1
Phellinus Linteus
1
1
Phenethyl isothiocyanate
1
1
Phloretin
1
1
Piceatannol
1
1
Piperlongumine
1
1
Pomegranate Peel
1
1
Prunella vulgaris
1
1
Psychedelics:All
1
1
Puerarin
1
1
Pycnogenol (Pine Bark)
1
1
Raspberry
1
1
Reishi Mushroom
1
1
Rice: Black
1
1
Rosemaric Acid
1
1
Sesame Seeds
1
1
Soursop
1
1
Soybean: Black
1
1
Syrian rue
1
1
Terminalia
1
1
Terminalia Chebula Gall Extract
1
1
Theaflavins
1
1
Thistle
1
1
Tocotrienol: Gamma
1
1
Toona sinensis
1
1
Traditional Chinese Medicine: Mylabris
1
1
Turmeric
1
1
Tyrosol
1
1
Vitamin A
1
1
Wheat Grass
1
1
Wogonin
1
1
Research Articles
442
Cumulative Knowledge Score
715
Overall Research Rating
EXCELLENT
View the Evidence:
555 Abstracts with Matrix metalloproteinase-2 (MMP-2) inhibitor Research
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[+]
CoQ10 supplementation reduced some of the important markers of inflammation and MMPs in patients with breast cancer.
May 31, 2021
Click here to read the entire abstract
Pubmed Data
: Inflammopharmacology. 2021 Jun ;29(3):579-593. Epub 2021 May 18. PMID:
34008150
Article Published Date
: May 31, 2021
Study Type
: Meta Analysis, Review
Additional Links
Substances
:
Coenzyme Q10
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-8 downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
A vegetarian diet is associated with a healthier profile of cardiovascular biomarkers compared to omnivorous.
Aug 01, 2016
Click here to read the entire abstract
Pubmed Data
: Clin Chim Acta. 2016 Aug 2 ;461:110-113. Epub 2016 Aug 2. PMID:
27496081
Article Published Date
: Aug 01, 2016
Study Type
: Human Study
Additional Links
Diseases
:
Cardiovascular Disease: Prevention
,
Cardiovascular Diseases
Therapeutic Actions
:
Dietary Modification: Vegetarian
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Risk Reduction
[+]
Aerobic training and purslane seed ere effective in the regulation of diabetic biomarkers associated with atherosclerosis in women with T2D.
Dec 04, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 Dec 5 ;6:37819. Epub 2016 Dec 5. PMID:
27917862
Article Published Date
: Dec 04, 2016
Study Type
: Human Study
Additional Links
Substances
:
Purslane
Diseases
:
Atherosclerosis
,
Diabetes Mellitus: Type 2
Therapeutic Actions
:
Exercise: Aerobic
Pharmacological Actions
:
Hypoglycemic Agents
,
Hypolipidemic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
MicroRNA modulator
,
NF-kappaB Inhibitor
,
Uricosuric Agents
Additional Keywords
:
Risk Reduction
[+]
EGCG has a protective effect against matrix metallopreinase in recessive dystrophic epidermolysis bullosa patients.
Apr 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Invest Dermatol. 2007 Apr;127(4):821-8. Epub 2006 Nov 30. PMID:
17139264
Article Published Date
: Apr 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Catechin
Diseases
:
Epidermolysis Bullosa
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Epigallocatechin gallate could potentially be used as a supplement of traditional rt-PA treatment among stroke patients.
Dec 08, 2016
Click here to read the entire abstract
Pubmed Data
: Clin Neuropharmacol. 2016 Dec 9. Epub 2016 Dec 9. PMID:
27941526
Article Published Date
: Dec 08, 2016
Study Type
: Human Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Brain Ischemia
,
Stroke: Attenuation/Recovery
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
[+]
Fisetin prolongs therapy window of brain ischemic stroke using tissue plasminogen activator.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619871359. PMID:
31434498
Article Published Date
: Dec 31, 2018
Study Type
: Human Study
Additional Links
Substances
:
Fisetin
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
[+]
Genistein may block metastasis and mortality in prostate cancer through blocking the activation of MEK4 and MMP-2 expression.
Aug 19, 2009
Click here to read the entire abstract
Pubmed Data
: J Natl Cancer Inst. 2009 Aug 19;101(16):1141-55. Epub 2009 Jul 28. PMID:
19638505
Article Published Date
: Aug 19, 2009
Study Type
: Human Study
Additional Links
Substances
:
Genistein
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Mitogen-activated protein kinase kinase 4 (MEK4)
[+]
Hesperidin reduces adverse symptomatic intracerebral hemorrhage.
Sep 01, 2019
Click here to read the entire abstract
Pubmed Data
: Neurol Sci. 2019 Sep 2. Epub 2019 Sep 2. PMID:
31478148
Article Published Date
: Sep 01, 2019
Study Type
: Human Study
Additional Links
Substances
:
Hesperidin
Diseases
:
Cerebral Hemorrhage
,
Stroke: Ischemic
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Olive oil inhibits ageing signs induced by chronic stress.
Mar 31, 2019
Click here to read the entire abstract
Pubmed Data
: Int J Cosmet Sci. 2019 Apr ;41(2):156-163. Epub 2019 Mar 6. PMID:
30740755
Article Published Date
: Mar 31, 2019
Study Type
: Human Study
Additional Links
Substances
:
Olive
Diseases
:
Aging Skin
,
Oxidative Stress
,
Stress
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Omega-3 fatty acids cause a reduction in the mRNA levels for various proteins known to be important in the pathology of osteoarthritis.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Osteoarthritis Cartilage. 2009 Jul;17(7):896-905. Epub 2009 Jan 13. PMID:
19217322
Article Published Date
: Jul 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
DHA (Docosahexaenoic Acid)
,
Eicosapentaenoic acid (EPA)
,
Omega-3 Fatty Acids
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 alpha downregulation
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Pomegranate juice significantly modulates matrix metalloproteinases 2 and 9 and serum levels of inflammatory factors protecting against exercise induced oxidative injury.
Jun 30, 2014
Click here to read the entire abstract
Pubmed Data
: J Pak Med Assoc. 2014 Jul ;64(7):785-90. PMID:
25255587
Article Published Date
: Jun 30, 2014
Study Type
: Human Study
Additional Links
Substances
:
Pomegranate
Diseases
:
Oxidative Stress
Pharmacological Actions
:
Anti Inflammatory
,
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Phytotherapy
,
Prolonged Exercise
[+]
Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2009 Dec;12(6):1252-9. PMID:
20041778
Article Published Date
: Dec 01, 2009
Study Type
: Human Study
Additional Links
Substances
:
Corni Fructus
,
Ginseng
,
Torilus Fructus
,
Unspecified Species
Diseases
:
Aging Skin
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Regular probiotic yoghurt consumption guarded against exhaustive exercise-inducing oxidative injury in young healthy females.
Nov 30, 2018
Click here to read the entire abstract
Pubmed Data
: J Pak Med Assoc. 2018 Dec ;68(12):1748-1754. PMID:
30504936
Article Published Date
: Nov 30, 2018
Study Type
: Human Study
Additional Links
Substances
:
Yoghurt
Diseases
:
Inflammation
,
Muscle Damage: Exercise-Induced
,
Oxidative Stress
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Selenium supplementation among diabetic nephropathy patients had favourable effects on serum MMP-2, plasma NO, TAC and GSH.
Sep 19, 2016
Click here to read the entire abstract
Pubmed Data
: Br J Nutr. 2016 Sep 20:1-7. Epub 2016 Sep 20. PMID:
27647263
Article Published Date
: Sep 19, 2016
Study Type
: Human Study
Additional Links
Substances
:
Selenium
Diseases
:
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Nitric Oxide Inhibitor
[+]
The hypotensive and anti-inflammatory effect of soy nut consumption may be due to a reduction in solube vascular cell adhesion molecule-1 which results in an improvement in endothelial function.
Jul 01, 2008
Click here to read the entire abstract
Pubmed Data
: Am J Cardiol. 2008 Jul 1;102(1):84-6. Epub 2008 Apr 16. PMID:
18572041
Article Published Date
: Jul 01, 2008
Study Type
: Human Study
Additional Links
Substances
:
Isoflavones
,
Soy Protein
Diseases
:
C-Reactive Protein
,
Hypertension
,
Inflammation
Pharmacological Actions
:
Interleukin-6 Downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Vascular Cell Adhesion Molecule-1 Inhibitor
[+]
This study showed a clinically relevant decrease in MMP-2 activity in patients with migraine treated with acupuncture.
Sep 30, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acupunct Med. 2014 Oct ;32(5):376-80. Epub 2014 Aug 27. PMID:
25164776
Article Published Date
: Sep 30, 2014
Study Type
: Human Study
Additional Links
Diseases
:
Headache: Migraine
Therapeutic Actions
:
Acupuncture
Pharmacological Actions
:
Analgesics
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Significant Treatment Outcome
[+]
Ginsenoside 20(S)-Rh2 has therapeutic potential for the treatment with colorectal cancer.
Dec 23, 2016
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2016 Dec 24 ;194:83-90. Epub 2016 Aug 23. PMID:
27566200
Article Published Date
: Dec 23, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Ginseng
,
Ginsenosides
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Chemosensitizer
,
Interleukin-6 Downregulation
,
Matrix metalloproteinase-1 (MMP-1) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Chemotherapeutic Synergy: Doxorubicin
[+]
Mandarin juice exerts in vitro antiproliferative effects on anaplastic thyroid carcinoma cells, associated with a reduction of migration.
Sep 11, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 Sep 12:1-8. Epub 2015 Sep 12. PMID:
26365817
Article Published Date
: Sep 11, 2015
Study Type
: Human In Vitro
Additional Links
Substances
:
Orange: Mandarin
Diseases
:
Thyroid Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Autophagy Up-regulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Parthenolide is a potential novel therapeutic agent for aggressive colorectal cancer treatment.
Mar 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Intest Res. 2017 Apr ;15(2):174-181. Epub 2017 Apr 27. PMID:
28522946
Article Published Date
: Mar 31, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Feverfew
,
Parthenolide
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Bcl-xL down-regulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Piperine inhibits the proliferation of human osteosarcoma cells via G2/M phase arrest and prevents metastasis.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2015 Jan ;24(1):50-8. Epub 2014 Nov 20. PMID:
25479727
Article Published Date
: Dec 31, 2014
Study Type
: Human In Vitro
Additional Links
Substances
:
Piperine
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Shikonin and temozolomide may constitute a powerful new tool for Glioblastoma treatment by reducing therapy resistance and tumor recurrence.
Apr 10, 2017
Click here to read the entire abstract
Pubmed Data
: Cell Oncol (Dordr). 2017 Apr 11. Epub 2017 Apr 11. PMID:
28401486
Article Published Date
: Apr 10, 2017
Study Type
: Human In Vitro
Additional Links
Substances
:
Shikonin
Diseases
:
Glioblastoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Anti-metastatic
,
Antiproliferative
,
Chemotherapeutic Synergy: Temozolomide
,
Glioblastoma
,
Shikonin
[+]
The addition of broccoli and watercress in the diet may reduce risk of breast cancer
Dec 01, 2005
Click here to read the entire abstract
Pubmed Data
: Toxicol Appl Pharmacol. 2005 Dec 1 ;209(2):105-13. Epub 2005 Jun 13. PMID:
15953625
Article Published Date
: Dec 01, 2005
Study Type
: Human In Vitro
Additional Links
Substances
:
Broccoli
,
Sulforaphane
,
Watercress
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Isothiocyanates
,
Plant Extracts
[+]
Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging
Feb 29, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cytotechnology. 2016 Mar ;68(2):229-40. Epub 2014 Jul 23. PMID:
25052044
Article Published Date
: Feb 29, 2016
Study Type
: Human In Vitro
Additional Links
Substances
:
Chrysanthemum Indicum
Diseases
:
Aging Skin
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Photoprotective
[+]
Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID:
25954974
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Prostaglandin PGE2 downregulation
[+]
"Low molecular weight fucoidan prevents intimal hyperplasia in rat injured thoracic aorta through the modulation of matrix metalloproteinase-2 expression."
Jan 14, 2011
Click here to read the entire abstract
Pubmed Data
: Biochem Pharmacol. 2011 Jan 15 ;81(2):233-43. Epub 2010 Sep 29. PMID:
20887714
Article Published Date
: Jan 14, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Aortic Plaques
,
Intima Media Thickening
Pharmacological Actions
:
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
A Chinese herbal formula containing Red Sage, Cordyceps and Peach kernel is superior to methylprednisone against experimental pulmonary fibrosis.
May 01, 2007
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Yao Za Zhi. 2007 May;32(9):835-9. PMID:
17639988
Article Published Date
: May 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Red Sage
Diseases
:
Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Superiority of Natural Substances versus Drugs
[+]
A combination of Omega-3 fatty acids and vitamin E ameliorates or prevents vascular reactivity alterations in diabetes.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2009 Dec;87(12):1063-73. PMID:
20029543
Article Published Date
: Dec 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Omega-3 Fatty Acids
,
Vitamin E
Diseases
:
Diabetes: Cardiovascular Illness
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
A lipid-soluble ginseng extract potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2015 Jan ;18(1):102-8. PMID:
25354136
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Ginseng
Diseases
:
Melanoma
,
Melanoma: Metastasis
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Dose Response
[+]
A red yeast rice extract inhibits the proliferation of colorectal cancer cells.
Mar 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2008 Mar;11(1):91-8. PMID:
20356949
Article Published Date
: Mar 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Red Yeast Rice
Diseases
:
Cancer Metastasis
,
Colorectal Cancer
Pharmacological Actions
:
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Allicin inhibits the proliferation and invasion in cholangiocarcinoma.
May 21, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2018 May 22 ;47(2):641-653. Epub 2018 May 22. PMID:
29794468
Article Published Date
: May 21, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Allicin
Diseases
:
Cholangiocarcinoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Ameliorative effects of high intensity interval training and Lactobacillus rhamnosus GG Protect against tetracycline-induced fatty liver.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: EXCLI J. 2022 ;21:991-1006. Epub 2022 Jul 21. PMID:
36110559
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus rhamnosus GG
Diseases
:
Nonalcoholic fatty liver disease (NAFLD)
Therapeutic Actions
:
Exercise
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-1 (MMP-1) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Gene Expression Regulation
[+]
Anthocyanins derived from Vitis coignetiae Pulliat contributes anti-cancer effects in Hep3B human hepatocellular carcinoma cells.
Nov 19, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2020 Nov 20 ;25(22). Epub 2020 Nov 20. PMID:
33233701
Article Published Date
: Nov 19, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Anthocyanins
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Anti-obesity effect of rice bran extract on high-fat diet-induced obese mice.
Jun 29, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Prev Nutr Food Sci. 2022 Jun 30 ;27(2):172-179. PMID:
35919566
Article Published Date
: Jun 29, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Rice Bran
Diseases
:
High Fat Diet
,
Obesity
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Anticancer effects of Gleditsia sinensis extract in rats transplanted with hepatocellular carcinoma cells.
Aug 07, 2019
Click here to read the entire abstract
Pubmed Data
: Oncol Res. 2019 Aug 8 ;27(8):889-899. Epub 2019 Apr 2. PMID:
30940289
Article Published Date
: Aug 07, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Gleditsia sinensis
Diseases
:
Breast Cancer
,
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Antitumor activity of ginsenoside Rg3 in melanoma through downregulation of the ERK and Akt pathways.
May 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Oncol. 2019 Jun ;54(6):2069-2079. Epub 2019 Apr 16. PMID:
31081060
Article Published Date
: May 31, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Melanoma
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Apigenin protects against ovalbumin-induced asthma.
Jul 01, 2009
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2009 Jul;9(7-8):918-24. Epub 2009 Apr 5. PMID:
19345747
Article Published Date
: Jul 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Asthma
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells.
Jan 14, 2011
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2011 Jan 15 ;18(2-3):158-62. Epub 2010 Aug 23. PMID:
20739158
Article Published Date
: Jan 14, 2011
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Artemisinin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Astragaloside IV and curcumin alone and in combination significantly reduced mean tumor weight compared to vehicle control.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2017 02 ;37(2):465-473. PMID:
28179291
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Astragaloside
,
Curcumin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
MicroRNA modulator
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Natural Substance Synergy
[+]
Attenuation of lipid metabolic abnormalities, proinflammatory cytokines, and matrix metalloproteinase expression by biochanin.
Mar 14, 2021
Click here to read the entire abstract
Pubmed Data
: Drug Chem Toxicol. 2021 Mar 15:1-12. Epub 2021 Mar 15. PMID:
33719799
Article Published Date
: Mar 14, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Biochanin A
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Hypolipidemic
,
Interleukin-1 alpha downregulation
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Avocado/soybean unsaponifiables have a protective effect against experimental dog osteoarthritis.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: Arthritis Res Ther. 2009;11(2):R41. Epub 2009 Mar 16. PMID:
19291317
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Avocado
,
Soy
,
Unsaponifiables
,
Vitamin E
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Nitric Oxide Inhibitor
Additional Keywords
:
Plant Extracts
[+]
Baicalein alleviated myocardial remodelling and improved cardiac function.
Jan 14, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Jan 15 ;145:213-23. Epub 2015 Dec 17. PMID:
26706290
Article Published Date
: Jan 14, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Baicalein
Diseases
:
Heart Failure
Pharmacological Actions
:
Anti-Apoptotic
,
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Berberine as a promising natural compound for the treatment of periodontal disease.
Oct 29, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cell Mol Med. 2021 Oct 30. Epub 2021 Oct 30. PMID:
34719112
Article Published Date
: Oct 29, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Periodontal Diseases
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-17 downregulation
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Berberine attenuates experimental autoimmune encephalomyelitis in mice.
Jan 01, 2010
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2010;5(10):e13489. Epub 2010 Oct 19. PMID:
20976070
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Blood-Brain-Barrier Disorders
,
Brain Inflammation
,
Multiple Sclerosis
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway.
Jul 22, 2018
Click here to read the entire abstract
Pubmed Data
: Oncol Res. 2018 Jul 23. Epub 2018 Jul 23. PMID:
30037363
Article Published Date
: Jul 22, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Biochanin A
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Biochanin-A alleviates fibrosis and inflammation in cardiac injury.
Jun 30, 2023
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2023 Jul ;37(7):e23360. Epub 2023 Apr 4. PMID:
37016276
Article Published Date
: Jun 30, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Biochanin A
Diseases
:
Inflammation
,
Myocardial Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Blue LED irradiation inhibits cancer cell migration and invasion in vitro and in vivo.
Jan 17, 2017
Click here to read the entire abstract
Pubmed Data
: J Cell Physiol. 2017 Jan 18. Epub 2017 Jan 18. PMID:
28098340
Article Published Date
: Jan 17, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Diseases
:
Colon Cancer
,
Fibrosarcoma
Therapeutic Actions
:
Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Blueberry inhibits the growth and metastatic potential of triple negative breast cancer in vitro and in vivo.
May 01, 2010
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2010 May 1;70(9):3594-605. Epub 2010 Apr 13. PMID:
20388778
Article Published Date
: May 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Blueberry
,
Flavonoids
,
Polyphenols
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Caffeic acid phenethyl ester may be a potential therapeutic agent for patients with advanced PCa.
May 14, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 May 15. Epub 2016 May 15. PMID:
27191743
Article Published Date
: May 14, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Bee Propolis
,
Caffeic acid phenethyl ester
Diseases
:
Cancer Metastasis
,
Prostate Cancer
Pharmacological Actions
:
Anti-metastatic
,
Chemotherapeutic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Wnt/β-catenin signaling pathway modulation
[+]
Camptothecin encapsulated with N-trimethyl chitosan exhibits anti-cancer properties in a preclinical mouse model of liver cancer.
Nov 01, 2010
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2010 Nov 1 ;297(1):56-64. Epub 2010 May 23. PMID:
20546992
Article Published Date
: Nov 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Camptothecin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Antiproliferative
,
Apoptotic
,
Chemopreventive
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Cannabinoids inhibit the growth of gliomas in vivo by targeting both tumor cells and vascular endothelial cells.
Feb 28, 2003
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: FASEB J. 2003 Mar ;17(3):529-31. Epub 2003 Jan 2. PMID:
12514108
Article Published Date
: Feb 28, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Cannabinoids
Diseases
:
Cancers: All
,
Gliomas
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Vascular Endothelial Growth Factor Regulator
Additional Keywords
:
Disease Regression
[+]
Carnosine protects against cerebral ischemic injury by inhibiting matrix-metalloproteinases.
Jul 12, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2021 Jul 13 ;22(14). Epub 2021 Jul 13. PMID:
34299128
Article Published Date
: Jul 12, 2021
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Carnosine
Diseases
:
Brain Ischemia
,
Stroke
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
[+]
Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice.
Nov 29, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Chin Med. 2020 Nov 30 ;15(1):125. Epub 2020 Nov 30. PMID:
33292347
Article Published Date
: Nov 29, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
Oolong tea
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
CBD can be used as a novel therapeutic option to inhibit growth and metastasis of highly aggressive breast cancer subtypes including TNBC.
Mar 31, 2015
Click here to read the entire abstract
Pubmed Data
: Mol Oncol. 2015 Apr ;9(4):906-19. Epub 2015 Jan 19. PMID:
25660577
Article Published Date
: Mar 31, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cannabidiol
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Epidermal growth factor receptor (EGFR) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
Chamomile and Nettle extract may be an effective supplement in improving the histological and immunological changes of PCOS.
Apr 02, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: BMC Complement Med Ther. 2023 Apr 3 ;23(1):102. Epub 2023 Apr 3. PMID:
37013510
Article Published Date
: Apr 02, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Chamomile
,
Nettle
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Chrysin attenuates interstitial fibrosis and improves cardiac function in a rat model of acute myocardial infarction.
Sep 16, 2018
Click here to read the entire abstract
Pubmed Data
: J Mol Histol. 2018 Sep 17. Epub 2018 Sep 17. PMID:
30225683
Article Published Date
: Sep 16, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Chrysin
Diseases
:
Fibrosis
,
Myocardial Infarction
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
Components of Salvia miltiorrhiza Bunge, could inhibit the development of elastase-induced experimental abdominal aortic aneurysms.
Nov 30, 2012
Click here to read the entire abstract
Pubmed Data
: J Surg Res. 2012 Dec ;178(2):1029-37. Epub 2012 May 17. PMID:
22640888
Article Published Date
: Nov 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Red Sage
Diseases
:
Aneurysm: Aortic
,
Hypertension
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Cordyceps militaris fraction inhibits the invasion and metastasis of lung cancer cells
Nov 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2018 Dec ;16(6):6930-6939. Epub 2018 Sep 27. PMID:
30546425
Article Published Date
: Nov 30, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Cordyceps Militaris
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Cryptotanshinone could be developed as a potential therapeutic agent for the treatment of chronic diabetic wound healing.
Nov 30, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharm Biol. 2020 Dec ;58(1):845-853. PMID:
32870741
Article Published Date
: Nov 30, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Salvia miltiorrhiza
Diseases
:
Diabetes Mellitus: Type 2
,
Wound Healing
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Curcumin improves left ventricular function in pressure overloaded rabbits.
Feb 01, 2004
Click here to read the entire abstract
Pubmed Data
: Biol Pharm Bull. 2004 Feb;27(2):198-202. PMID:
14758033
Article Published Date
: Feb 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Left Ventricular Dysfunction
,
Left Ventricular Hypertrophy
Pharmacological Actions
:
Cardiovascular Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin inhibits prostate cancer tumors.
Dec 01, 2009
Click here to read the entire abstract
Pubmed Data
: Peptides. 2009 Dec;30(12):2357-64. Epub 2009 Sep 20. PMID:
19772879
Article Published Date
: Dec 01, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Curcumin inhibits the growth of choroidal melanoma.
Jan 15, 2011
Click here to read the entire abstract
Pubmed Data
: Cancer Biol Ther. 2011 Jan 15;11(2):229-35. Epub 2011 Jan 15. PMID:
21084858
Article Published Date
: Jan 15, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Melanoma
,
Melanoma: Choroidal
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts.
Aug 01, 2010
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2010 Aug;54(8):1192-201. PMID:
20087857
Article Published Date
: Aug 01, 2010
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Glioblastoma
Pharmacological Actions
:
Anti-Angiogenic
,
Anticarcinogenic Agents
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Curcumin may have a beneficial effect in degenerative aortic aneurysms.
May 01, 2006
Click here to read the entire abstract
Pubmed Data
: Ann Vasc Surg. 2006 May;20(3):360-8. Epub 2006 May 19. PMID:
16779518
Article Published Date
: May 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Aortic Aneurysm
Pharmacological Actions
:
Interleukin-6 Downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
[+]
Curcumin prevents human aortic smooth muscle cells migration associated with the development atherosclerosis.
Feb 01, 2010
Click here to read the entire abstract
Pubmed Data
: Nutr Metab Cardiovasc Dis. 2010 Feb;20(2):125-32. Epub 2009 May 17. PMID:
19447587
Article Published Date
: Feb 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Curcumin protects against alcohol and oxidized fat-induced liver toxicity.
Jul 01, 2004
Click here to read the entire abstract
Pubmed Data
: Ital J Biochem. 2004 Jul;53(2):61-6. PMID:
15646009
Article Published Date
: Jul 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Alcohol Toxicity
,
Chemically-Induced Liver Damage
Pharmacological Actions
:
Hepatoprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Curcumin works synergistically with paclitaxel to inhibit breast cancer cell metastasis to the lung in a mouse model.
Oct 15, 2005
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2005 Oct 15;11(20):7490-8. PMID:
16243823
Article Published Date
: Oct 15, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Breast Cancer
,
Breast Cancer: Lung Metastasis
,
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
Additional Keywords
:
Drug: Paclitaxel
,
Drug-Plant-Vitamin Synergies
[+]
Curcumin's antiulcer activity is primarily attributed to MMP-9 inhibition, one of the major path-ways of ulcer healing.
Mar 11, 2005
Click here to read the entire abstract
Pubmed Data
: J Biol Chem. 2005 Mar 11;280(10):9409-15. Epub 2004 Dec 22. PMID:
15615723
Article Published Date
: Mar 11, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Gastric Ulcer
,
Oxidative Stress
Pharmacological Actions
:
Anti-Ulcer Agents
,
Gastroprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Drug: Indomethacin
[+]
Curcumin, when used as a complementary treatment to albendazole, could help to alleviate eosinophilic meningitis through suppression of eosinophil count in the cerebrospinal fluid.
Feb 29, 2012
Click here to read the entire abstract
Pubmed Data
: Parasitology. 2012 Mar ;139(3):358-65. Epub 2011 Nov 7. PMID:
22053741
Article Published Date
: Feb 29, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Angiostrongylus Cantonensis Infection
,
Eosinophilic Meningitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis.
Mar 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2017 Apr ;15(4):2339-2346. Epub 2017 Feb 22. PMID:
28260017
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
D-Limonene
Diseases
:
Ulcerative Colitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Postaglandin PGE2 downregulation
[+]
Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2016 Jul ;14(1):955-62. Epub 2016 May 18. PMID:
27222119
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Daidzein
,
Isoflavones
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Dietary intake of EPA and DHA prevented abdominal aortic aneurysm development.
Dec 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Circ J. 2015 ;79(7):1470-8. Epub 2015 Apr 30. PMID:
25925976
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
DHA (Docosahexaenoic Acid)
,
EPA (Eicosapentaenoic Acid)
,
Omega-3 Fatty Acids
Diseases
:
Aneurysm: Aortic
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Dietary red palm oil supplementation reduces myocardial infarct size in an isolated perfused rat heart model.
Mar 01, 2002
Click here to read the entire abstract
Pubmed Data
: J Clin Endocrinol Metab. 2002 Mar;87(3):1010-4. PMID:
20565865
Article Published Date
: Mar 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Palm Oil
Diseases
:
Myocardial Infarction
Pharmacological Actions
:
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Dl-3-n-butylphthalide attenuates spinal cord injury.
Aug 31, 2021
Click here to read the entire abstract
Pubmed Data
: Neurochem Res. 2021 Sep ;46(9):2297-2306. Epub 2021 Jun 4. PMID:
34086144
Article Published Date
: Aug 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Celery Oil
Diseases
:
Hypoxia
,
Spinal Cord Injuries
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
[+]
ECG may be used as an anti-invasion agent for the adjuvant treatment and metastasis control of human lung cancer cells.
Jul 31, 2016
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2016 Aug ;94:1-10. Epub 2016 May 17. PMID:
27224248
Article Published Date
: Jul 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Fibronectin
[+]
Effect of hyperbaric oxygen treatment in a rat model of abdominal aortic aneurysm.
Dec 31, 2013
Click here to read the entire abstract
Pubmed Data
: Undersea Hyperb Med. 2014 Jan-Feb;41(1):9-15. PMID:
24649712
Article Published Date
: Dec 31, 2013
Study Type
: Animal Study
Additional Links
Diseases
:
Aneurysm: Aortic
Therapeutic Actions
:
Hyperbaric Treatment
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Effect of silibinin on the expression of MMP2, MMP3, MMP9 and TIMP2 in kidney and lung after hepatic ischemia/reperfusion injury.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Acta Cir Bras. 2021 ;36(9):e360904. Epub 2021 Nov 8. PMID:
34755764
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Silibinin
Diseases
:
Liver Injury: Ischemia/reperfusion
Pharmacological Actions
:
Hepatoprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
EGCG attenuated abdominal aortic aneurysm progression in a rat model by preserving the aortic thickness and elastin content of the medial layer.
May 31, 2017
Click here to read the entire abstract
Pubmed Data
: J Vasc Surg. 2017 Jun ;65(6):1803-1812.e2. Epub 2016 Jul 26. PMID:
27473778
Article Published Date
: May 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate)
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Ellagic acid may be beneficial for the treatment of glioblastoma.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Feb ;37(2):1084-1092. Epub 2016 Dec 22. PMID:
28035411
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ellagic Acid
Diseases
:
Glioblastoma
Pharmacological Actions
:
Antiproliferative
,
Bcl-2 protein down-regulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug.
Jan 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Trop Med. 2016 Feb ;9(2):180-3. Epub 2016 Jan 11. PMID:
26919952
Article Published Date
: Jan 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor A Inhibitor
,
Vascular Endothelial Growth Factor C Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.
Dec 21, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Dec 22 ;86:441-449. Epub 2016 Dec 22. PMID:
28012923
Article Published Date
: Dec 21, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Rosemary
,
Rosmarinic acid
Diseases
:
Brain Inflammation
,
Neuropathic Pain
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Nitric Oxide Inhibitor
,
Prostaglandin PGE2 downregulation
Additional Keywords
:
Plant Extracts
[+]
Fermented lettuce extract containing nitric oxide metabolites attenuates inflammatory parameters.
Feb 22, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2023 Feb 23 ;15(5). Epub 2023 Feb 23. PMID:
36904105
Article Published Date
: Feb 22, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Fermented Foods and Beverages
,
Lettuce
Diseases
:
Arthritis
,
Rheumatoid Arthritis
Pharmacological Actions
:
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Folic acid modulates matrix metalloproteinase-9 expression following spinal cord injury.
Mar 31, 2019
Click here to read the entire abstract
Pubmed Data
: Ann Neurosci. 2019 Apr ;26(2):60-65. Epub 2019 Apr 1. PMID:
31975775
Article Published Date
: Mar 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Folic Acid
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Fucoidan ameliorated the development of high fat diet-induced NAFLD.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2015 Nov ;40(3):907-14. Epub 2015 Oct 23. PMID:
26498267
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Insulin Resistance
,
Nonalcoholic fatty liver disease (NAFLD)
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Fucoidan suppresses hypoxia-induced lymphangiogenesis and lymphatic metastasis in mouse hepatocarcinoma.
Jun 02, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mar Drugs. 2015 Jun 3 ;13(6):3514-30. Epub 2015 Jun 3. PMID:
26047481
Article Published Date
: Jun 02, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Fucoidan
Diseases
:
Hypoxia
,
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Garlic may be effective for preventing skin photoaging accelerated by UV irradiation through the antioxidative system and MMP regulation.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2016 ;21(1). Epub 2016 Jan 8. PMID:
26760989
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Garlic
Diseases
:
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Matrix metalloproteinase-1 (MMP-1) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Photoprotective
[+]
Genistein aglycone might be an effective alternative therapy for the management of age-related skin changes in postmenopausal women.
Jan 31, 2012
Click here to read the entire abstract
Pubmed Data
: Br J Pharmacol. 2012 Feb ;165(4):994-1005. PMID:
21827449
Article Published Date
: Jan 31, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Genistein
,
Soy
Diseases
:
Aging Skin
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords
:
Drug: Raloxifene
,
Ovariectomy-Induced Changes
[+]
Geraniol enhances peroxiredoxin-1, and prevents isoproterenol-induced oxidative stress and inflammation associated with myocardial infarction.
Jul 31, 2022
Click here to read the entire abstract
Pubmed Data
: J Biochem Mol Toxicol. 2022 Aug ;36(8):e23098. Epub 2022 May 24. PMID:
35608392
Article Published Date
: Jul 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Geraniol
Diseases
:
Inflammation
,
Lipid Peroxidation
,
Myocardial Infarction
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Problem Substances
:
Isoproterenol
[+]
Ginkgetin ameliorates experimental atherosclerosis.
May 31, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Jun ;102:510-516. Epub 2018 Mar 24. PMID:
29579712
Article Published Date
: May 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Nitric Oxide Inhibitor
[+]
Ginkgo biloba extract inhibits metastasis and in gastric cancer.
Sep 10, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Med Sci Monit. 2019 Sep 11 ;25:6836-6845. Epub 2019 Sep 11. PMID:
31509521
Article Published Date
: Sep 10, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Ginsenoside AD-2 ameliorating lipopolysaccharide-induced activation in HSC-T6 cells and carbon tetrachloride-induced hepatic fibrosis.
Jan 15, 2023
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2023 Jan 16. Epub 2023 Jan 16. PMID:
36644954
Article Published Date
: Jan 15, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Chemically-Induced Liver Damage
,
Lipopolysaccharide-Induced Toxicity
,
Liver Fibrosis
Pharmacological Actions
:
Hepatoprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Ginsenoside Rb1 attenuates angiotensin II-induced abdominal aortic aneurysm.
Sep 30, 2015
Click here to read the entire abstract
Pubmed Data
: Vascul Pharmacol. 2015 Oct ;73:86-95. Epub 2015 Apr 22. PMID:
25912763
Article Published Date
: Sep 30, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Ginsenoside Rg1 may represent a novel treatment target for spinal cord injury.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Pharm Bull. 2017 ;40(10):1630-1637. PMID:
28966235
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Spinal Cord Injuries
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Ginsenoside Rg3 decreases fibrotic and invasive nature of endometriosis.
Dec 14, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2017 Dec 15 ;7(1):17670. Epub 2017 Dec 15. PMID:
29247225
Article Published Date
: Dec 14, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Endometriosis
Pharmacological Actions
:
Anti-Fibrotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
MicroRNA modulator
[+]
Ginsenoside Rg3 inhibition of vasculogenic mimicry in pancreatic cancer.
Aug 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Oncol. 2014 Sep ;45(3):1065-72. Epub 2014 Jun 16. PMID:
24938458
Article Published Date
: Aug 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Ginsenoside Rg3 might be a useful agent for the treatment of metastatic thyroid cancers.
Aug 31, 2018
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2018 Sep ;21(9):849-857. Epub 2018 Aug 23. PMID:
30136914
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Thyroid Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Grape juice concentrate protects rat liver against cadmium intoxication.
Jun 30, 2016
Click here to read the entire abstract
Pubmed Data
: Drug Res (Stuttg). 2016 Jul ;66(7):339-44. Epub 2016 Apr 7. PMID:
27056637
Article Published Date
: Jun 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Grape
Diseases
:
Chemically-Induced Liver Damage
Pharmacological Actions
:
Hepatoprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Plant Extracts
Problem Substances
:
Cadmium
[+]
Grape juice has a hypolipidemic and cardiac protective potential.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2020 ;15(9):e0238163. Epub 2020 Sep 3. PMID:
32881885
Article Published Date
: Dec 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Grape
Diseases
:
Dyslipidemias
Pharmacological Actions
:
Hypolipidemic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Natural Substances Versus Drugs
[+]
Green tea polyphenol and EGCG induce programmed cell death and inhibit invasion in human breast cancer cells.
Dec 01, 2007
Click here to read the entire abstract
Pubmed Data
: Cancer Biol Ther. 2007 Dec;6(12):1938-43. Epub 2007 Sep 1. PMID:
18059161
Article Published Date
: Dec 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
Catechin
,
Flavonoids
,
Polyphenols
Diseases
:
Breast Cancer
,
Breast Cancer: Metastatic
Pharmacological Actions
:
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Hu Zhang (Polygonum cuspidatum), a rich source of resveratrol, inhibits the expression of inflammation in lung fibroblasts and reduces alveolitis and pulmonary fibrosis.
Jun 01, 2009
Click here to read the entire abstract
Pubmed Data
: Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(12):1574-7. PMID:
19777850
Article Published Date
: Jun 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Hu Zhang (Polygonum cuspidatum)
,
Resveratrol
Diseases
:
Chemotherapy-Induced Toxicity: Bleomycin
,
Pulmonary Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Hyperforin, a compound found within St. John's wort, has powerful anti-inflammatory therapeutic potential in reducing lung fibrosis.
May 01, 2007
Click here to read the entire abstract
Pubmed Data
: J Pharmacol Exp Ther. 2007 May;321(2):492-500. Epub 2007 Feb 8. PMID:
17289834
Article Published Date
: May 01, 2007
Study Type
: Animal Study
Additional Links
Substances
:
St. Johns Wort
Diseases
:
Chemotherapy-Induced Toxicity: Bleomycin
,
Cystic Fibrosis
,
Pulmonary Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Inhibiting tumour metastasis by DQA modified paclitaxel plus ligustrazine micelles in treatment of non-small-cell lung cancer.
Nov 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):3465-3477. PMID:
31432702
Article Published Date
: Nov 30, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ligustrazine
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Anti-metastatic
,
Chemotherapeutic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Chemothapeutic Synergy: Paclitaxel
[+]
Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma.
Dec 31, 2015
Click here to read the entire abstract
Pubmed Data
: Sci Rep. 2016 ;6:21731. Epub 2016 Feb 25. PMID:
26911838
Article Published Date
: Dec 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Apigenin
Diseases
:
Cancer Metastasis
,
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
STAT3 Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Inhibitory effects of formononetin on the monocrotaline‑induced pulmonary arterial hypertension.
Feb 29, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2020 Mar ;21(3):1192-1200. Epub 2020 Jan 3. PMID:
31922224
Article Published Date
: Feb 29, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Formononetin
Diseases
:
Hypertension: Pulmonary
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antihypertensive Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
Isoliquiritigenin suppresses the proliferation and induced apoptosis via miR-32/LATS2/Wnt in nasopharyngeal carcinoma.
Aug 04, 2019
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2019 Aug 5 ;856:172352. Epub 2019 Apr 17. PMID:
31004603
Article Published Date
: Aug 04, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Isoliquiritigenin
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
MicroRNA modulator
,
Wnt/β-catenin signaling pathway modulation
[+]
Kaempferol can safely inhibit the metastasis of the 786-O RCC cells into the lungs by about 87.4%.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Med Sci. 2017 ;14(10):984-993. Epub 2017 Aug 18. PMID:
28924370
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Kaempferol
Diseases
:
Kidney Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
treatment outcome
[+]
Lactobacillus paracasei GMNL-32 exerts a therapeutic effect on cardiac abnormalities in mice.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: PLoS One. 2017 ;12(9):e0185098. Epub 2017 Sep 21. PMID:
28934296
Article Published Date
: Dec 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Lactobacillus paracasei
Diseases
:
Cardiovascular Disease
,
Lupus Erythematosus: Systemic
Pharmacological Actions
:
Anti-Apoptotic
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Light-emitting diode therapy increases collagen deposition during the repair process of skeletal muscle.
Feb 11, 2016
Click here to read the entire abstract
Pubmed Data
: Lasers Med Sci. 2016 Feb 12. Epub 2016 Feb 12. PMID:
26873500
Article Published Date
: Feb 11, 2016
Study Type
: Animal Study
Additional Links
Diseases
:
Inflammation
,
Wounds and Injuries
Therapeutic Actions
:
Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Liquiritigenin potentiates the inhibitory effects of cisplatin on invasion and metastasis in B16F10 melanoma cells.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 ;67(5):761-70. Epub 2015 May 15. PMID:
25978595
Article Published Date
: Dec 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Liquiritigenin
Diseases
:
Cancer Metastasis
,
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Chemotherapeutic Synergy: Cisplatin
[+]
Luteolin can be a chemotherapeutic agent against colorectal cancer.
Oct 31, 2014
Click here to read the entire abstract
Pubmed Data
: Hum Exp Toxicol. 2014 Nov ;33(11):1176-85. Epub 2014 Feb 14. PMID:
24532706
Article Published Date
: Oct 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Luteolin
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Chemotherapeutic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Luteolin inhibits proliferation and induces apoptosis of human melanoma cells.
Jan 20, 2019
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2019 Jan 21. Epub 2019 Jan 21. PMID:
30663726
Article Published Date
: Jan 20, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Luteolin
Diseases
:
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Lycopene inhibits experimental metastasis of human hepatoma in athymic mice.
Mar 01, 2008
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2008 Mar ;138(3):538-43. PMID:
18287363
Article Published Date
: Mar 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Lycopene
Diseases
:
Cancer Metastasis
,
Liver Cancer
,
Lung Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Vascular Endothelial Growth Factor A Inhibitor
[+]
Lycopene is a natural compound that was able to inhibit the production of ROS and mitigate the damage caused by acetaminophen.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2017 Feb 1 ;263:7-17. Epub 2016 Dec 15. PMID:
27989599
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Carotenoids
,
Lycopene
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Liver Damage: Drug-Induced
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Acetaminophen (Tylenol) Toxicity
,
Antioxidants
,
CAROTENOIDS
,
Hepatoprotective
,
Liver Damage: Drug-Induced
,
lycopene
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
oxidative stress
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in mice.
Jan 31, 2017
Click here to read the entire abstract
Pubmed Data
: Bioorg Med Chem. 2017 Feb 1 ;25(3):1057-1065. Epub 2016 Dec 18. PMID:
28031152
Article Published Date
: Jan 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Lycopene
Diseases
:
Acetaminophen (Tylenol) Toxicity
,
Liver Damage: Drug-Induced
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Acetaminophen (Tylenol) Toxicity
,
Anti-Inflammatory Agents
,
Hepatoprotective
,
Liver Damage: Drug-Induced
,
lycopene
Problem Substances
:
Acetaminophen
,
Paracetamol
[+]
Lycopene provides protection against development of diabetic nephropathy.
Oct 09, 2015
Click here to read the entire abstract
Pubmed Data
: Biofactors. 2015 Oct 10. Epub 2015 Oct 10. PMID:
26453295
Article Published Date
: Oct 09, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Lycopene
Diseases
:
Advanced Glycation End products (AGE)
,
Diabetic Nephropathy
Pharmacological Actions
:
Anti-Glycation Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
[+]
Mangiferin relieves carbon tetrachloride-induced liver fibrosis.
Mar 12, 2023
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2023 Mar 13 ;13(1):4172. Epub 2023 Mar 13. PMID:
36914687
Article Published Date
: Mar 12, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Mangiferin
Diseases
:
Liver Cirrhosis
,
Liver Fibrosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Hepatoprotective
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Melatonin and curcumin protect against ndomethacin-induced acute gastric ulceration.
Sep 15, 2006
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30. PMID:
16934674
Article Published Date
: Sep 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
,
Melatonin
Diseases
:
Drug-Induced Toxicity: Indomethacin
,
Gastric Ulcer
Pharmacological Actions
:
Antioxidants
,
Gastroprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Drug: Indomethacin
[+]
Melatonin and pycnogenol have a therapeutic role in the treatment fo endothelial dysfunction.
Aug 01, 2003
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2003 Aug;12(2):269-73. PMID:
20421515
Article Published Date
: Aug 01, 2003
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
,
Melatonin
Diseases
:
Endothelial Dysfunction
,
Hypertension
Pharmacological Actions
:
Antihypertensive Agents
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Melatonin has cardioprotective effects in a rat model of cardiorenal syndrome.
Jul 27, 2016
Click here to read the entire abstract
Pubmed Data
: J Pineal Res. 2016 Jul 28. Epub 2016 Jul 28. PMID:
27465663
Article Published Date
: Jul 27, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Heart Disease
,
Kidney Diseases
,
Multi-Organ Failure
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cardioprotective
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway.
May 01, 2006
Click here to read the entire abstract
Pubmed Data
: Ai Zheng. 2006 May;25(5):582-6. PMID:
20609072
Article Published Date
: May 01, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Endometriosis
Pharmacological Actions
:
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Metformin in combination with curcumin inhibits the growth, metastasis and angiogenesis of hepatocellular carcinoma.
Aug 18, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Carcinog. 2017 Aug 19. Epub 2017 Aug 19. PMID:
28833603
Article Published Date
: Aug 18, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Curcumin
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Natural Substance/Drug Synergy
[+]
Morroniside protects against cerebral ischemia/reperfusion injury.
Aug 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2018 Sep ;16(3):2229-2234. Epub 2018 Jul 17. PMID:
30186462
Article Published Date
: Aug 31, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Dogwood
Diseases
:
Cerebral Ischemia
Pharmacological Actions
:
Anti-Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
[+]
Naturally fermented Noni juice manifests a protective potential on liver fibrosis.
Mar 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Chin Med Assoc. 2017 Apr ;80(4):212-221. Epub 2017 Mar 6. PMID:
28268174
Article Published Date
: Mar 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Fermented Foods and Beverages
,
Noni
Diseases
:
Liver Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Antioxidants
,
Hepatoprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke.
Jan 07, 2021
Click here to read the entire abstract
Pubmed Data
: Neuroreport. 2021 09 8 ;32(13):1140-1146. PMID:
34284451
Article Published Date
: Jan 07, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Ginsenosides
,
Salvia miltiorrhiza
Diseases
:
Stroke: Ischemic
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
[+]
Nobiletin ameliorates the cardiovascular dysfunction of diabetes by inhibiting oxidative stress, MMP-2 and MMP-9.
Jul 12, 2016
Click here to read the entire abstract
Pubmed Data
: Food Funct. 2016 Jul 13 ;7(7):3121-9. PMID:
27279123
Article Published Date
: Jul 12, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Nobiletin
Diseases
:
Cardiovascular Diseases
,
Diabetic Complications
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Nobiletin may have potential use as a chemopreventive agent against nasopharyngeal cancer metastasis.
Feb 28, 2015
Click here to read the entire abstract
Pubmed Data
: Expert Opin Ther Targets. 2015 Mar ;19(3):307-20. Epub 2015 Jan 7. PMID:
25563790
Article Published Date
: Feb 28, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Nobiletin
Diseases
:
Nasopharyngeal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Chemopreventive
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Oral administration of black ginger extract significantly prevents UVB-induced photoaging in hairless mice.
Sep 30, 2014
Click here to read the entire abstract
Pubmed Data
: Photodermatol Photoimmunol Photomed. 2014 Oct ;30(5):237-45. Epub 2014 Jan 9. PMID:
24313661
Article Published Date
: Sep 30, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Kaempferia parviflora
Diseases
:
Aging Skin
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Catalase Up-Regulation
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
,
Photoprotective
Additional Keywords
:
Plant Extracts
[+]
Oral Aloe vera gel powder has the ability to prevent the skin photoaging.
Apr 03, 2016
Click here to read the entire abstract
Pubmed Data
: Biosci Biotechnol Biochem. 2016 Apr 4:1-9. Epub 2016 Apr 4. PMID:
27045316
Article Published Date
: Apr 03, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Aloe Vera
Diseases
:
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Photoprotective
[+]
Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin induced toxicity.
Apr 01, 2010
Click here to read the entire abstract
Pubmed Data
: Am J Clin Nutr. 2010 Apr;91(4):940-9. Epub 2010 Mar 3. PMID:
20200256
Article Published Date
: Apr 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Orange
Diseases
:
Endotoxemia
,
Inflammation
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Paeoniflorin attenuates DHEA-induced polycystic ovary syndrome.
Feb 25, 2021
Click here to read the entire abstract
Pubmed Data
: Aging (Albany NY). 2021 Feb 26 ;13(5):7084-7095. Epub 2021 Feb 26. PMID:
33638949
Article Published Date
: Feb 25, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Paeoniflorin
Diseases
:
Polycystic Ovary Syndrome
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Paeoniflorin attenuates postoperative pain by suppressing matrix metalloproteinase-9/2 in mice.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Eur J Pain. 2018 02 ;22(2):272-281. Epub 2017 Oct 29. PMID:
29081070
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Paeoniflorin
Diseases
:
Allodynia
,
Hyperalgesia
Pharmacological Actions
:
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Paeoniflorin inhibits migration and invasion of human glioblastoma cells.
Feb 28, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Neurochem Res. 2018 Mar ;43(3):760-774. Epub 2018 Feb 8. PMID:
29423667
Article Published Date
: Feb 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Paeoniflorin
Diseases
:
Cancer Metastasis
,
Glioblastoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Paeonol exerts anti-angiogenic and anti-metastatic activities.
Jun 30, 2009
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Pharm Bull. 2009 Jul ;32(7):1142-7. PMID:
19571375
Article Published Date
: Jun 30, 2009
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Paeonol
Diseases
:
Cancers: All
Pharmacological Actions
:
Anti-Angiogenic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Parthenolide generates reactive oxygen species and autophagy in MDA-MB231 cells.
Oct 30, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Death Dis. 2013 Oct 31 ;4:e891. Epub 2013 Oct 31. PMID:
24176849
Article Published Date
: Oct 30, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Parthenolide
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Autophagy Up-regulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Pharmacological effects of natural components against ovarian cancer and mechanisms.
Dec 31, 2020
Click here to read the entire abstract
Pubmed Data
: Adv Exp Med Biol. 2021 ;1330:55-73. PMID:
34339030
Article Published Date
: Dec 31, 2020
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ellagic Acid
,
Lignans
,
Luteolin
,
Mangiferin
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Pinocembrin pretreatment may represent a novel means of increasing the safety and the therapeutic time window of t-PA following ischemic stroke.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Res Int. 2018 ;2018:8943210. Epub 2018 Apr 22. PMID:
29850586
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Brain Ischemia
,
Stroke
,
Thrombosis
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Neuroprotective Agents
[+]
Pro-apoptotic, anti-metastatic, and anti-telomerase activity of Tinospora cordifolia and its active polysaccharide arabinogalactan during Benzo(a)pyrene-induced lung carcinogenesis.
Apr 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Indian J Pharmacol. 2022 May-Jun;54(3):198-207. PMID:
35848691
Article Published Date
: Apr 30, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Guduchi
Diseases
:
Benzo[a]pyrene-induced Toxicity
,
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Plant Extracts
,
Polysaccharides
[+]
probiotic treatment attenuates fibrosis in a diet-induced nonalcoholic fatty liver model in mice.
Mar 01, 2009
Click here to read the entire abstract
Pubmed Data
: Hepatology. 2009 Mar;49(3):989-97. PMID:
19115316
Article Published Date
: Mar 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Probiotics
Diseases
:
Fatty Liver
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
[+]
Protective effects of paeoniflorin on alveolar bone resorption and soft-tissue breakdown in experimental periodontitis.
Mar 31, 2016
Click here to read the entire abstract
Pubmed Data
: J Periodontal Res. 2016 Apr ;51(2):257-64. Epub 2015 Jul 14. PMID:
26179445
Article Published Date
: Mar 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Paeoniflorin
Diseases
:
Periodontitis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Pterostilbene attenuates high-fat diet and dextran sulfate sodium-induced colitis.
Jun 20, 2021
Click here to read the entire abstract
Pubmed Data
: J Agric Food Chem. 2021 Jun 21. Epub 2021 Jun 21. PMID:
34152136
Article Published Date
: Jun 20, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Pterostilbene
Diseases
:
Colitis
,
Fibrosis
Pharmacological Actions
:
Anti-Fibrotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Gastroprotective
,
Interleukin-1 beta downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Quercetin alleviates pulmonary fibrosis in mice exposed to silica by inhibiting macrophage senescence.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2022 ;13:912029. Epub 2022 Jul 26. PMID:
35959439
Article Published Date
: Dec 31, 2021
Study Type
: Animal Study
Additional Links
Substances
:
Quercetin
Diseases
:
Pulmonary Fibrosis
,
Silicosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Matrix Metalloproteinase-12 (MMP-12) Inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Transforming growth factor beta (TGF-β) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Quercetin reduces oxidative stress and inhibits activation of c Jun N terminal kinase/activator protein 1 signalling.
Jan 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2014 Feb ;9(2):435-42. Epub 2013 Dec 6. PMID:
24337353
Article Published Date
: Jan 31, 2014
Study Type
: Animal Study
Additional Links
Substances
:
Quercetin
Diseases
:
Aneurysm: Aortic
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Riboflavin and ultraviolet A irradiation for the prevention of progressive myopia.
Jan 11, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Eye Res. 2017 12 ;165:1-6. Epub 2017 Aug 31. PMID:
28864176
Article Published Date
: Jan 11, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Riboflavin (Vitamin B-2)
Diseases
:
Myopia
Therapeutic Actions
:
Sunlight exposure
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Saffron aqueous extract exerted dose-dependent anti-atherosclerotic and plaque-stabilizing effects in mice.
Oct 31, 2017
Click here to read the entire abstract
Pubmed Data
: Atherosclerosis. 2017 Nov 1. Epub 2017 Nov 1. PMID:
29128090
Article Published Date
: Oct 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Saffron
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-atherogenic
,
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Salvianolic acid C significantly ameliorated the progression of aortic aneurysm in mice.
Nov 30, 2016
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2016 Dec 1 ;166:75-81. Epub 2016 Sep 20. PMID:
27663582
Article Published Date
: Nov 30, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Polyphenols
,
Red Sage
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Sea cucumber extract TBL-12 could suppress the proliferation and metastasis of human prostate cancer cells.
Mar 18, 2019
Click here to read the entire abstract
Pubmed Data
: Prostate. 2019 Mar 19. Epub 2019 Mar 19. PMID:
30889629
Article Published Date
: Mar 18, 2019
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Sea Cucumber
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights.
Dec 31, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Redox Biol. 2018 06 ;16:169-178. Epub 2018 Mar 1. PMID:
29505920
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Verbascoside
Diseases
:
Lung Cancer
Pharmacological Actions
:
Apoptotic
,
Immunomodulatory
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Selective Cytotoxicity
[+]
Sesamol attenuates experimentally induced myocardial infarction.
Jan 01, 2011
Click here to read the entire abstract
Pubmed Data
: Cell Physiol Biochem. 2011 ;27(3-4):273-80. Epub 2011 Apr 1. PMID:
21471716
Article Published Date
: Jan 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Sesamol
Diseases
:
Hypertension
,
Myocardial Infarction
Pharmacological Actions
:
Antioxidants
,
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Short-interval exposure to ambient fine particulate matter (PM2.5) exacerbates the susceptibility of pulmonary damage.
Apr 30, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biomed Pharmacother. 2019 May ;113:108737. Epub 2019 Mar 7. PMID:
30852418
Article Published Date
: Apr 30, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Melatonin
Diseases
:
Air Pollution Linked Toxicity
,
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Sika deer (Cervus nippon) velvet antler extract attenuates prostate cancer in xenograft model.
Jan 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biosci Biotechnol Biochem. 2019 Feb ;83(2):348-356. Epub 2018 Oct 31. PMID:
30381032
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Velvet antler
Diseases
:
Prostate Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Stevia prevents experimental cirrhosis by reducing hepatic myofibroblasts and modulating molecular profibrotic pathways.
Jan 31, 2019
Click here to read the entire abstract
Pubmed Data
: Hepatol Res. 2019 Feb ;49(2):212-223. Epub 2018 Nov 19. PMID:
30338893
Article Published Date
: Jan 31, 2019
Study Type
: Animal Study
Additional Links
Substances
:
Stevia
Diseases
:
Liver Cirrhosis
,
Liver Disease
Pharmacological Actions
:
Hepatoprotective
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Transforming growth factor beta (TGF-β) inhibitor
[+]
Sulforaphane elicits antioxidant, anti-inflammatory, and extracellular matrix remodelling effects in a rat model of diabetic peripheral neuropathy.
Aug 01, 2018
Click here to read the entire abstract
Pubmed Data
: Inflammation. 2018 Aug ;41(4):1460-1476. PMID:
29704151
Article Published Date
: Aug 01, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane
Diseases
:
Inflammation
,
Oxidative Stress
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Interleukin-10 upregulation
,
Malonaldehyde (MDA) Down-Regulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Neuroprotective Agents
,
NF-kappaB Inhibitor
,
Nitric Oxide Inhibitor
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Broccoli
,
Broccoli Sprouts
,
Cruciferous Vegetables
,
Isothiocyanates
[+]
Supplementation with lycopene-enriched tomato extract may counteract hepatocellular carcinoma progression or protect against disease onset.
Oct 31, 2015
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 Nov-Dec;67(8):1268-75. Epub 2015 Oct 16. PMID:
26474105
Article Published Date
: Oct 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Lycopene
,
Tomato
Diseases
:
Liver Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-metastatic
,
Anticarcinogenic Agents
,
Chemopreventive
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer.
Aug 01, 2010
Click here to read the entire abstract
Pubmed Data
: Mol Cancer Ther. 2010 Aug;9(8):2255-64. Epub 2010 Jul 20. PMID:
20647339
Article Published Date
: Aug 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
Additional Keywords
:
Drug Synergy
[+]
Tanshinone II A can improve cardiac function, inhibit myocardial fibrosis and improve myocardial remodeling in rats with I/R-induced heart failure.
May 31, 2022
Click here to read the entire abstract
Pubmed Data
: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2022 Jun ;34(6):640-645. PMID:
35924522
Article Published Date
: May 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Tanshinone IIA
Diseases
:
Heart Failure
,
Myocardial Fibrosis
,
Myocardial Ischemia
Pharmacological Actions
:
Anti-Fibrotic
,
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Tanshinone IIA attenuates the development of elastase-induced experimental abdominal aortic aneurysms.
Sep 30, 2012
Click here to read the entire abstract
Pubmed Data
: Zhonghua Wai Ke Za Zhi. 2012 Oct ;50(10):923-7. PMID:
23302465
Article Published Date
: Sep 30, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Red Sage
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Tanshinone IIA reduces the risk of Alzheimer's disease.
Jul 31, 2014
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2014 Aug ;10(2):689-94. Epub 2014 May 20. PMID:
24859152
Article Published Date
: Jul 31, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Tanshinone IIA
Diseases
:
Alzheimer's Disease
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Neuroprotective Agents
Additional Keywords
:
Risk Reduction
[+]
Tetramethylpyrazine may be a potential candidate for neuropathic pain treatment.
Aug 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Neuroinflammation. 2017 Aug 31 ;14(1):174. Epub 2017 Aug 31. PMID:
28859670
Article Published Date
: Aug 30, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Ligustrazine
Diseases
:
Neuropathic Pain
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vasodilator Agents
[+]
The combination of CS plus metronomic ZOL demonstrated significant antitumor, anti-metastatic and anti-osteolytic effects against breast cancer
May 19, 2015
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2015 May 20. Epub 2015 May 20. PMID:
25998578
Article Published Date
: May 19, 2015
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Green Tea
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Natural Substance/Drug Synergy
Problem Substances
:
Zoledronic Acid
[+]
The dietary ingestion of Aloe sterols protected against chronic UVB damage in mouse skin.
Dec 19, 2016
Click here to read the entire abstract
Pubmed Data
: Photodermatol Photoimmunol Photomed. 2016 Dec 20. Epub 2016 Dec 20. PMID:
27995657
Article Published Date
: Dec 19, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Aloe Vera
Diseases
:
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Matrix Metalloproteinase-12 (MMP-12) Inhibitor
,
Matrix Metalloproteinase-13 (MMP-13) Inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Photoprotective
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords
:
Aloe vera
,
Anti-Inflammatory Agents
,
Interleukin-1 beta downregulation
,
Ultraviolet Radiation Induced Damage
[+]
The main components of pomegranate can inhibit metastasis of ovarian cancer.
Nov 26, 2017
Click here to read the entire abstract
Pubmed Data
: Cancer Biol Ther. 2017 Nov 27:1-10. Epub 2017 Nov 27. PMID:
29173024
Article Published Date
: Nov 26, 2017
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Ellagic Acid
,
Luteolin
,
Pomegranate
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Therapeutic applications of garlic and turmeric for the diabetic wound healing in mice.
Nov 03, 2022
Click here to read the entire abstract
Pubmed Data
: J Burn Care Res. 2022 Nov 4. Epub 2022 Nov 4. PMID:
36331804
Article Published Date
: Nov 03, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Garlic
,
Turmeric
Diseases
:
Diabetic Complications
,
Wound Healing
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix Metalloproteinase-7 (MMP-7) Inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
These data indicate that quercetin may be useful for the prevention and treatment of abdominal aortic aneurysms.
Sep 04, 2012
Click here to read the entire abstract
Pubmed Data
: Eur J Pharmacol. 2012 Sep 5 ;690(1-3):133-41. Epub 2012 Jun 19. PMID:
22728078
Article Published Date
: Sep 04, 2012
Study Type
: Animal Study
Additional Links
Substances
:
Quercetin
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
These findings reveal a new potential therapeutic application of curcumin in anti-metastatic therapy for endometrial carcinoma.
Aug 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2015 Sep ;10(3):1297-1302. Epub 2015 Jul 9. PMID:
26622667
Article Published Date
: Aug 31, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin
Diseases
:
Endometrial Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
These findings show that baicalein is an effective agent for abdominal aortic aneurysm prevention.
Aug 31, 2016
Click here to read the entire abstract
Pubmed Data
: Sci China Life Sci. 2016 Sep ;59(9):940-9. Epub 2016 Jun 22. PMID:
27333787
Article Published Date
: Aug 31, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Baicalein
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
These results demonstrated that salvianolic acid A held great potential for aortic aneurysm therapy.
Sep 14, 2014
Click here to read the entire abstract
Pubmed Data
: Phytomedicine. 2014 Sep 15 ;21(10):1137-45. Epub 2014 Jun 7. PMID:
24916705
Article Published Date
: Sep 14, 2014
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Red Sage
Diseases
:
Aortic Aneurysm
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Superiority of Natural Substances versus Drugs
[+]
These results indicated that isoliquiritigenin attenuates progression of osteoarthritis.
Jan 28, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2018 01 29 ;8(1):1721. Epub 2018 Jan 29. PMID:
29379010
Article Published Date
: Jan 28, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Isoliquiritigenin
Diseases
:
Osteoarthritis
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Osteoprotective
[+]
These results suggest that kefir ameliorated chronic unpredictable stress-induced anxiety-like behavior.
Mar 31, 2023
Click here to read the entire abstract
Pubmed Data
: Probiotics Antimicrob Proteins. 2023 Apr ;15(2):411-423. Epub 2022 Dec 19. PMID:
36534210
Article Published Date
: Mar 31, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Kefir
Diseases
:
Anxiety
,
Oxidative Stress
Pharmacological Actions
:
Anti-Anxiety Agents
,
Antioxidants
,
Brain-derived neurotrophic factor modulator
,
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Renoprotective
,
Superoxide Dismutase Up-regulation
[+]
These results suggest that piperine free P. nigrum extracts can enhance breast cancer cell response to phytochemicals.
May 03, 2016
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2016 May 4. Epub 2016 May 4. PMID:
27155135
Article Published Date
: May 03, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Black Pepper
Diseases
:
Breast Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Suppressor Protein p53 Upregulation
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Bioenhancer
,
Natural Substance Synergy
[+]
These results suggest that treatment with EGb 761 in mice prevented the development of CaCl2-induced abdominal aortic aneurysm.
Oct 27, 2013
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2013 Oct 28 ;150(1):308-15. Epub 2013 Sep 5. PMID:
24012526
Article Published Date
: Oct 27, 2013
Study Type
: Animal Study
Additional Links
Substances
:
Ginkgo biloba
Diseases
:
Aneurysm: Aortic
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
This study confirmed the usefulness of pomegranate polyphenols in the treatment of MetS and the prevention of kidney damage.
Dec 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oxid Med Cell Longev. 2023 ;2023:6144967. Epub 2023 Jan 5. PMID:
36644578
Article Published Date
: Dec 31, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Polyphenols
,
Pomegranate
Diseases
:
Chronic Kidney Disease (CKD)
,
Metabolic Syndrome X
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Superoxide Dismutase Up-regulation
Additional Keywords
:
Plant Extracts
[+]
This study demonstrated tanshinone IIA suppressed the progression of atherosclerosis.
Apr 14, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Biol Open. 2017 Apr 15 ;6(4):489-495. Epub 2017 Apr 15. PMID:
28412716
Article Published Date
: Apr 14, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Tanshinone IIA
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
This study suggests an effect of apple polyphenols and apple anthocyanin Cy3Gal against colon carcinogenesis.
May 18, 2020
Click here to read the entire abstract
Pubmed Data
: J Nutr Biochem. 2020 May 19 ;83:108418. Epub 2020 May 19. PMID:
32592950
Article Published Date
: May 18, 2020
Study Type
: Animal Study
Additional Links
Substances
:
Apple
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anticarcinogenic Agents
,
Chemopreventive
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Thymoquinone loaded in nanostructured lipid carrier showed enhanced anticancer activity.
Dec 31, 2017
Click here to read the entire abstract
Pubmed Data
: Nanomedicine (Lond). 2018 07 ;13(13):1567-1582. PMID:
30028248
Article Published Date
: Dec 31, 2017
Study Type
: Animal Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Thymoquinone suppresses angiogenesis in DEN-induced hepatocellular carcinoma by targeting miR-1-3p.
Dec 13, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2022 Dec 14 ;23(24). Epub 2022 Dec 14. PMID:
36555545
Article Published Date
: Dec 13, 2022
Study Type
: Animal Study
Additional Links
Substances
:
Thymoquinone
Diseases
:
Liver Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Total saponins from Rosa laevigata can be applied as one effective candidate for the treatment of liver fibrosis.
Jun 14, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Nutrients. 2015 Jun 15 ;7(6):4829-50. Epub 2015 Jun 15. PMID:
26083117
Article Published Date
: Jun 14, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Rose
Diseases
:
Chemically-Induced Liver Damage
,
Liver Cirrhosis
,
Oxidative Stress
Pharmacological Actions
:
Antioxidants
,
Hepatoprotective
,
Malondialdehyde Down-regulation
,
Matrix metalloproteinase-1 (MMP-1) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Superoxide Dismutase Up-regulation
[+]
Treatment of berberine alleviates diabetic nephropathy by reducing iron overload and inhibiting oxidative stress.
Feb 23, 2023
Click here to read the entire abstract
Pubmed Data
: Histol Histopathol. 2023 Feb 24:18599. Epub 2023 Feb 24. PMID:
36861878
Article Published Date
: Feb 23, 2023
Study Type
: Animal Study
Additional Links
Substances
:
Berberine
Diseases
:
Diabetic Nephropathy
,
Iron Overload
Pharmacological Actions
:
Anti-Fibrotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Renoprotective
[+]
Triptolide inhibited B16F10 cell migration and invasion via the inhibition of NF-κB expression
Sep 28, 2015
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2015 Sep 29. Epub 2015 Sep 29. PMID:
26420756
Article Published Date
: Sep 28, 2015
Study Type
: Animal Study
Additional Links
Substances
:
Triptolide
Diseases
:
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
Ursolic acid ameliorated the severity of abdominal aortic aneurysms.
Feb 14, 2018
Click here to read the entire abstract
Pubmed Data
: Atherosclerosis. 2018 Feb 15 ;271:128-135. Epub 2018 Feb 15. PMID:
29499360
Article Published Date
: Feb 14, 2018
Study Type
: Animal Study
Additional Links
Substances
:
Ursolic Acid
Diseases
:
Aortic Aneurysm
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Vitamin C in combination with vitamin K3 inhibits primary tumor growth and exhibits antimetastastic potential in vivo through attenuated tumor invasion and proliferation.
Dec 31, 2010
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2011 ;63(7):1036-43. Epub 2011 Sep 2. PMID:
21888506
Article Published Date
: Dec 31, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Vitamin C
,
Vitamin K
Diseases
:
Lung Cancer
,
Lung Cancer: Metastatic
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Disease Regression
,
Dose Response
[+]
Zerumbone suppresses the motility and tumorigenecity of triple negative breast cancer cells.
Jan 11, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Jan 12 ;7(2):1544-58. PMID:
26637807
Article Published Date
: Jan 11, 2016
Study Type
: Animal Study, In Vitro Study
Additional Links
Substances
:
Zerumbone
Diseases
:
Breast Cancer: Triple Negative
,
Cancer Metastasis
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Zingerone suppresses angiogenesis via inhibition of matrix metalloproteinases during tumor development.
Jul 25, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2016 Jul 26 ;7(30):47232-47241. PMID:
27323807
Article Published Date
: Jul 25, 2016
Study Type
: Animal Study
Additional Links
Substances
:
Ginger
,
Polyphenols
Diseases
:
Cancers: All
Pharmacological Actions
:
angiogenesis
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Inhibition of programmed death ligand 1 (PD-L1) expression in breast cancer cells by sesamin.
Aug 31, 2020
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2020 Sep ;86:106759. Epub 2020 Jul 11. PMID:
32663768
Article Published Date
: Aug 31, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Sesamin
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Theaflavins suppress the growth and metastasis of human hepatocellular carcinoma.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Onco Targets Ther. 2016 ;9:4265-75. Epub 2016 Jul 14. PMID:
27478384
Article Published Date
: Dec 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Theaflavins
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
2,3,5,4 tetrahydroxy diphenylethylene 2 O glucoside inhibits the adhesion and invasion of A549 human lung cancer cells.
Nov 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2017 Dec ;16(6):8900-8906. Epub 2017 Oct 2. PMID:
28990072
Article Published Date
: Nov 30, 2017
Study Type
: In Vitro Study
Additional Links
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Dose Response
[+]
2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside suppresses human colorectal cancer cell metastasis.
Jul 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Oncol. 2016 Aug ;49(2):629-38. Epub 2016 Jun 9. PMID:
27278328
Article Published Date
: Jul 31, 2016
Study Type
: In Vitro Study
Additional Links
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
[+]
3,4,5-trihydroxybenzaldehyde from Geum japonicum has dual inhibitory effect on matrix metalloproteinase 9; inhibition of gelatinoytic activity.
Sep 30, 2008
Click here to read the entire abstract
Pubmed Data
: J Cell Biochem. 2008 Oct 1 ;105(2):524-33. PMID:
18773430
Article Published Date
: Sep 30, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Geum japonicum
,
Herb Bennet
Diseases
:
Atherosclerosis
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
6-shogaol inhibits the cell migration of colon cancer.
Dec 31, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Integr Cancer Ther. 2023 ;22:15347354231172732. PMID:
37157810
Article Published Date
: Dec 31, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
6-Shogaol
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
[+]
A combination of Citrus reticulata peel and black tea inhibits migration and invasion of liver cancer.
Oct 29, 2019
Click here to read the entire abstract
Pubmed Data
: Mol Biol Rep. 2019 Oct 30. Epub 2019 Oct 30. PMID:
31673889
Article Published Date
: Oct 29, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Black Tea
,
Citrus Peel
,
Orange: Mandarin
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Dose Response
[+]
A hydroalcoholic extract of oak acorn shell acts as a potent antiangiogenic agent.
Feb 28, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharm Biol. 2013 Mar ;51(3):361-8. Epub 2012 Nov 8. PMID:
23137183
Article Published Date
: Feb 28, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Oak
Diseases
:
Cancers: All
Pharmacological Actions
:
Anti-Angiogenic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Plant Extracts
[+]
A novel function of artesunate on inhibiting migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.
Jun 23, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Arthritis Res Ther. 2019 Jun 24 ;21(1):153. Epub 2019 Jun 24. PMID:
31234900
Article Published Date
: Jun 23, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Artesunate
Diseases
:
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
A review of formononetin and its anticancer potentials and mechanisms.
Dec 31, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Pharmacol. 2019 ;10:820. Epub 2019 Jul 26. PMID:
31402861
Article Published Date
: Dec 31, 2018
Study Type
: Review
Additional Links
Substances
:
Formononetin
Diseases
:
Cancers: All
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Chemopreventive
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
A Rheum palmatum extract has potential anti-metastatic activity.
Jun 30, 2015
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol Pharmacol. 2015 Jul ;40(1):30-8. Epub 2015 May 16. PMID:
26056975
Article Published Date
: Jun 30, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Rhubarb
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
A standardized Terminalia chebula fruit extract alters the expression of genes associated with skin architecture and barrier formation.
Oct 05, 2020
Click here to read the entire abstract
Pubmed Data
: Eur J Dermatol. 2020 Oct 6. Epub 2020 Oct 6. PMID:
33021480
Article Published Date
: Oct 05, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Terminalia chebula
Diseases
:
Aging Skin
,
Ultraviolet Radiation Induced Damage
Pharmacological Actions
:
Matrix Metalloproteinase-12 (MMP-12) Inhibitor
,
Matrix metalloproteinase-1 (MMP-1) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Photoprotective
[+]
Acacetin inhibits the invasion and migration of human non-small cell lung cancer A549 cells.
Mar 31, 2011
Click here to read the entire abstract
Pubmed Data
: Mol Cell Biochem. 2011 Apr ;350(1-2):135-48. Epub 2011 Jan 6. PMID:
21210297
Article Published Date
: Mar 31, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Flavonoids
Diseases
:
Cancer Metastasis
,
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
[+]
Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human lung cancer cells.
Dec 31, 2009
Click here to read the entire abstract
Pubmed Data
: J Food Sci. 2010 ;75(1):H30-8. PMID:
20492175
Article Published Date
: Dec 31, 2009
Study Type
: In Vitro Study
Additional Links
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
[+]
Acanthopanax senticosus polysaccharide suppressed the proliferation and metastasis of the human non-small cell lung cancer NCI-H520 cells.
Jul 22, 2019
Click here to read the entire abstract
Pubmed Data
: Neoplasma. 2019 Jul 23 ;66(4):555-563. Epub 2019 Mar 30. PMID:
30943746
Article Published Date
: Jul 22, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Ginseng (Siberian)
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Wnt/β-catenin signaling pathway modulation
Additional Keywords
:
Polysaccharides
[+]
Allicin may be recognized as an anti-invasive agent for lung adenocarcinoma treatment.
Jun 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2017 Jul ;14(1):468-474. Epub 2017 May 5. PMID:
28693193
Article Published Date
: Jun 30, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Allicin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Allyl isothiocyanate may be beneficial in the treatment of human colorectal adenocarcinoma in the future.
Dec 31, 2013
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Rep. 2014 Jan ;31(1):189-96. Epub 2013 Nov 20. PMID:
24270601
Article Published Date
: Dec 31, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Isothiocyanates
Diseases
:
Cancer Metastasis
,
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Aloin inhibits the proliferation and migration of gastric cancer cells.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Drug Des Devel Ther. 2020 ;14:145-155. Epub 2020 Jan 14. PMID:
32021099
Article Published Date
: Dec 31, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Aloe Vera
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
An ethanol extract of root of Prunus persica inhibited the growth of liver cancer cells.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Evid Based Complement Alternat Med. 2017 ;2017:8231936. Epub 2017 Oct 12. PMID:
29234432
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Peach
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cell cycle arrest
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Plant Extracts
[+]
An extract of Lotus may be a powerful agent against colon cancer cells.
Feb 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2017 Mar ;13(3):1470-1478. Epub 2016 Dec 28. PMID:
28454279
Article Published Date
: Feb 28, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Lotus
Diseases
:
Colon Cancer
Pharmacological Actions
:
Apoptotic
,
Bcl-2 protein down-regulation
,
Bcl-xL down-regulation
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
Additional Keywords
:
Apoptotic
,
Bcl-2 protein down-regulation
,
COLON CANCER
,
Lotus
,
Plant Extracts
[+]
Andrographolide may inhibit human colorectal cancer migration and invasion.
Aug 14, 2009
Click here to read the entire abstract
Pubmed Data
: Chem Biol Interact. 2009 Aug 14;180(3):344-52. Epub 2009 May 6. PMID:
19426720
Article Published Date
: Aug 14, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Andrographis
Diseases
:
Cancer Metastasis
,
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Annurca apple polyphenol extract promotes mesenchymal-to-epithelial transition and inhibits migration in triple-negative breast cancer cells.
Sep 27, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2020 Sep 28 ;10(1):15921. Epub 2020 Sep 28. PMID:
32985606
Article Published Date
: Sep 27, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Apple Polyphenols
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Anthocyanin from the fruit of Vitis Coignetiae acts as a potent inhibitor of TNF-α effect by inhibiting NF-κB-regulated genes in human breast cancer cells.
May 20, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2020 May 21 ;25(10). Epub 2020 May 21. PMID:
32455624
Article Published Date
: May 20, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Anthocyanins
,
Grape
Diseases
:
Breast Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-Inflammatory Agents
,
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Gene Expression Regulation
[+]
Anthocyanins from black rice could suppress CAL 27 cell metastasis by reduction of MMP-2, MMP-9, and NF-κB p65 expression.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Nutr Cancer. 2015 ;67(2):327-38. Epub 2015 Feb 6. PMID:
25658905
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Anthocyanins
,
Rice: Black
Diseases
:
Oral Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
Anthocyanins isolated from fruits of Vitis coignetiae Pulliat inhibit cancer proliferation, cancer migration, and invasion.
Jan 25, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Cancer Prev. 2017 11 26 ;18(11):2919-2923. Epub 2017 Nov 26. PMID:
29172259
Article Published Date
: Jan 25, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Anthocyanins
,
Grape
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Cyclin D1 Down-Regulation
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Anthraquinone metabolites from P. notoginseng, possess antitumor, antioxidant, antibacterial, and antiglycosidase activities.
Aug 09, 2023
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2023 Aug 10 ;312:116457. Epub 2023 Apr 21. PMID:
37088235
Article Published Date
: Aug 09, 2023
Study Type
: In Vitro Study
Additional Links
Substances
:
Panax Notoginseng
Diseases
:
Cancers: All
Pharmacological Actions
:
Anti-Bacterial Agents
,
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2.
Jan 31, 2013
Click here to read the entire abstract
Pubmed Data
: J Pharm Pharmacol. 2013 Feb ;65(2):310-6. Epub 2012 Oct 22. PMID:
23278699
Article Published Date
: Jan 31, 2013
Study Type
: In Vitro Study
Additional Links
Substances
:
Ginsenosides
Diseases
:
Inflammation
,
Lipopolysaccharide-Induced Toxicity
,
Oxidative Stress
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Anti-invasive activity of anthocyanins isolated from Vitis coignetiae in human hepatocarcinoma cells.
Sep 30, 2009
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2009 Oct ;12(5):967-72. PMID:
19857058
Article Published Date
: Sep 30, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Anthocyanins
,
Grape
Diseases
:
Cancer Metastasis
,
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
Additional Keywords
:
Phytotherapy
,
Plant Extracts
[+]
Anti-osteoarthritic effects of an herbal composition LI73014F2 on interleukin-1β-induced primary human articular chondrocytes.
Apr 26, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2020 Apr 27 ;25(9). Epub 2020 Apr 27. PMID:
32349389
Article Published Date
: Apr 26, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Frankincense
,
Terminalia chebula
,
Turmeric
Diseases
:
Osteoarthritis
Pharmacological Actions
:
5-Lipoxygenase Inhibitor
,
Anti-Apoptotic
,
Anti-Inflammatory Agents
,
Cyclooxygenase 2 Inhibitors
,
Interleukin-1 beta downregulation
,
Interleukin-6 Downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-3 (MMP-3) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]
Anti-tumor and anti-metastasis effects of berbamine-loaded lipid nanoparticles on pancreatic cancer.
Apr 30, 2022
Click here to read the entire abstract
Pubmed Data
: Anticancer Agents Med Chem. 2022 May 1. Epub 2022 May 1. PMID:
35490430
Article Published Date
: Apr 30, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Berbamine
Diseases
:
Pancreatic Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Anticancer potential of naringenin, biosynthesis, molecular target, and structural perspectives.
Sep 11, 2021
Click here to read the entire abstract
Pubmed Data
: Mini Rev Med Chem. 2021 Sep 12. Epub 2021 Sep 12. PMID:
34517796
Article Published Date
: Sep 11, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Naringenin
Diseases
:
Cancers: All
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Antimetastatic effects of licochalcone A on oral cancer via regulating metastasis-associated proteases.
Jul 31, 2014
Click here to read the entire abstract
Pubmed Data
: Tumour Biol. 2014 Aug ;35(8):7467-74. Epub 2014 May 1. PMID:
24789273
Article Published Date
: Jul 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Licorice
Diseases
:
Cancer Metastasis
,
Oral Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
[+]
Antimetastatic effects of sesamin on human head and neck squamous cell carcinoma.
May 09, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Molecules. 2020 May 10 ;25(9). Epub 2020 May 10. PMID:
32397656
Article Published Date
: May 09, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Sesamin
Diseases
:
Squamous cell carcinoma
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Antimetastatic potential of garcinone E in human oral cancer cells.
Jan 24, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Asian Pac J Cancer Prev. 2019 Jan 25 ;20(1):65-72. Epub 2019 Jan 25. PMID:
30678382
Article Published Date
: Jan 24, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Mangosteen
Diseases
:
Cancer Metastasis
,
Oral Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Antiproliferative effects of St. John's Wort, its derivatives, and other Hypericum species in hematologic malignancies.
Dec 24, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2020 Dec 25 ;22(1). Epub 2020 Dec 25. PMID:
33375664
Article Published Date
: Dec 24, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
St. Johns Wort
Diseases
:
Cancers: All
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Antitumor activity of alantolactone in lung cancer cell lines NCI-H1299 and Anip973.
Dec 31, 2018
Click here to read the entire abstract
Pubmed Data
: J Food Biochem. 2019 09 ;43(9):e12972. Epub 2019 Jul 5. PMID:
31489665
Article Published Date
: Dec 31, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Elecampane
Diseases
:
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix Metalloproteinase-7 (MMP-7) Inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Antitumor effects of saikosaponin b2 on breast cancer cell proliferation and migration.
Jul 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Mol Med Rep. 2019 Aug ;20(2):1943-1951. Epub 2019 Jun 13. PMID:
31257464
Article Published Date
: Jul 31, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Saikosaponin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
STAT3 Activation
[+]
Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cells.
Jan 21, 2015
Click here to read the entire abstract
Pubmed Data
: Toxicol Lett. 2015 Jan 22 ;232(2):490-8. Epub 2014 Dec 2. PMID:
25476160
Article Published Date
: Jan 21, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Mulberry
Diseases
:
Cancer Metastasis
,
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
,
STAT3 Inhibitor
[+]
Anti‑wrinkle effect of fermented black ginseng on human fibroblasts.
Feb 28, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Med. 2017 Mar ;39(3):681-686. Epub 2017 Jan 16. PMID:
28098856
Article Published Date
: Feb 28, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Ginseng
Diseases
:
Aging Skin
,
Wrinkles
Pharmacological Actions
:
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Apigenin 7-O-glucoside promotes cell apoptosis through the PTEN/PI3K/AKT pathway and inhibits cell migration in cervical cancer HeLa cells.
Nov 02, 2020
Click here to read the entire abstract
Pubmed Data
: Food Chem Toxicol. 2020 Nov 3 ;146:111843. Epub 2020 Nov 3. PMID:
33152472
Article Published Date
: Nov 02, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Apigenin
Diseases
:
Cervical Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Apple polyphenol inhibited the vitality, cell growth and proliferation, and migration of breast cancer cells MDA-MB-231
Oct 31, 2017
Click here to read the entire abstract
Pubmed Data
: Wei Sheng Yan Jiu. 2017 Nov ;46(6):960-964. PMID:
29903207
Article Published Date
: Oct 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Apple Polyphenols
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Arctigenin significantly inhibited the migration and invasion of MDA-MB-231 cells.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Jan ;37(1):179-184. Epub 2016 Nov 23. PMID:
27878294
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Burdock
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Artichoke leaf extract inhibits AKR1B1 and reduces NF-κB activity in human leukemic cells.
Feb 28, 2017
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2017 Mar ;31(3):488-496. Epub 2017 Jan 26. PMID:
28127803
Article Published Date
: Feb 28, 2017
Study Type
: In Vitro Study
Additional Links
Diseases
:
Inflammation
,
Leukemia
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Astragaloside IV inhibits breast cancer cell invasion.
Dec 31, 2016
Click here to read the entire abstract
Pubmed Data
: Int Immunopharmacol. 2017 Jan ;42:195-202. Epub 2016 Dec 5. PMID:
27930970
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
,
Cancer Metastasis
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Astragaloside IV inhibits progression of glioma cancer cells.
Sep 08, 2017
Click here to read the entire abstract
Pubmed Data
: Biochem Biophys Res Commun. 2017 Sep 9 ;491(1):98-103. Epub 2017 Jul 11. PMID:
28709870
Article Published Date
: Sep 08, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Astragaloside
Diseases
:
Glioma
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Atractylodes macrocephala can inhibit the proliferation and invasion of hepatocellular carcinoma cells.
Oct 29, 2019
Click here to read the entire abstract
Pubmed Data
: Nan Fang Yi Ke Da Xue Xue Bao. 2019 Oct 30 ;39(10):1180-1185. PMID:
31801717
Article Published Date
: Oct 29, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Bai Zhu
Diseases
:
Cancer Metastasis
,
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Wnt/β-catenin signaling pathway modulation
[+]
B. serrata extract inhibits proliferation, angiogenesis and migration and induces apoptosis in HT-29 cells
May 23, 2017
Click here to read the entire abstract
Pubmed Data
: Prostaglandins Other Lipid Mediat. 2017 May 24 ;131:1-8. Epub 2017 May 24. PMID:
28549801
Article Published Date
: May 23, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Frankincense
Diseases
:
Colon Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Prostaglandin PGE2 downregulation
,
Vascular Endothelial Growth Factor Inhibitors
Additional Keywords
:
Plant Extracts
[+]
Baicalein inhibits gastric cancer cell invasion and metastasis by reducing cell motility and migration via suppression of the p38 signaling pathway.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2015 Feb ;33(2):737-43. Epub 2014 Dec 11. PMID:
25502212
Article Published Date
: Jan 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Baicalein
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Dose Response
[+]
Baicalein is a potential novel therapeutic agent for patients with colorectal cancer.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2016 Jan ;11(1):685-688. Epub 2015 Nov 17. PMID:
26870267
Article Published Date
: Dec 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Baicalein
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Baicalein may be developed as a potential, novel anticancer treatment for tumors.
Oct 08, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2016 Oct 9 ;17(10). Epub 2016 Aug 9. PMID:
27735841
Article Published Date
: Oct 08, 2016
Study Type
: Review
Additional Links
Substances
:
Baicalein
Diseases
:
Cancers: All
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Baicalein suppresses colorectal carcinoma cell invasion.
Mar 31, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Apr ;37(4):2317-2323. Epub 2017 Feb 10. PMID:
28259937
Article Published Date
: Mar 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Baicalein
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Baicalin has the potential to be used in novel anti cancer therapeutic formulations for treatment of ovarian cancer.
Oct 09, 2017
Click here to read the entire abstract
Pubmed Data
: Mol Med Rep. 2017 Oct 10. Epub 2017 Oct 10. PMID:
29039573
Article Published Date
: Oct 09, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Baicalein
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Bee venom effect on glioblastoma cells viability and gelatinase secretion.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Neurosci. 2022 ;16:792970. Epub 2022 Feb 11. PMID:
35221898
Article Published Date
: Dec 31, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Bee Venom
Diseases
:
Glioblastoma
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion.
Aug 31, 2017
Click here to read the entire abstract
Pubmed Data
: Int J Oncol. 2017 Sep ;51(3):832-840. Epub 2017 Jul 27. PMID:
28766686
Article Published Date
: Aug 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Benzyl isothiocyanate
,
Phenethyl isothiocyanate
Diseases
:
Cancer Metastasis
,
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Isothiocyanates
[+]
Benzyl-isothiocyanate induces apoptosis and inhibits migration and invasion of hepatocellular carcinoma cells in vitro.
Dec 31, 2016
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Cancer. 2017 ;8(2):240-248. Epub 2017 Jan 15. PMID:
28243328
Article Published Date
: Dec 31, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Benzyl isothiocyanate
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Survivin Down-Regulation
[+]
Berbamine suppresses growth, migration and invasion of highly-metastatic human breast cancer cells.
Jan 01, 2009
Click here to read the entire abstract
Pubmed Data
: BMC Cancer. 2009;9:414. Epub 2009 Nov 30. PMID:
19796390
Article Published Date
: Jan 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Berbamine
Diseases
:
Breast Cancer
,
Cancer Metastasis
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor A Inhibitor
Additional Keywords
:
Drug-Plant-Vitamin Synergies
[+]
Berberine has a protective effect on ameliorating the lipopolysaccharide induced progression of adenomyosis.
Nov 30, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Exp Ther Med. 2017 Dec ;14(6):6125-6130. Epub 2017 Oct 16. PMID:
29285168
Article Published Date
: Nov 30, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Adenomyosis
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Adenomyosis
,
Anti-Inflammatory Agents
,
Berberine
,
Interleukin-6 Downregulation
,
Lipopolysaccharide-Induced Toxicity
[+]
Berberine hydrochloride inhibits cell proliferation and promotes apoptosis of non-small cell lung cancer.
Apr 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncol Lett. 2018 May ;15(5):7409-7414. Epub 2018 Mar 13. PMID:
29725453
Article Published Date
: Apr 30, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Carcinoma: Non-Small-Cell Lung
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Berberine may have potential applications as a chemotherapeutic agent for the management of head and neck squamous carcinoma.
Sep 24, 2015
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2015 Sep 25. Epub 2015 Sep 25. PMID:
26503508
Article Published Date
: Sep 24, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Head and Neck Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Tumor Suppressor Protein p53 Upregulation
[+]
Berberine might be a promising new strategy for the treatment of adenomyosis.
Dec 07, 2017
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharmacol Sci. 2017 Dec 8. Epub 2017 Dec 8. PMID:
29752208
Article Published Date
: Dec 07, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Adenomyosis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Interleukin-6 Downregulation
,
Interleukin-8 downregulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Berberine reverses epithelial-mesenchymal transition and modulates histone methylation in osteosarcoma cells.
Oct 18, 2020
Click here to read the entire abstract
Pubmed Data
: Mol Biol Rep. 2020 Oct 19. Epub 2020 Oct 19. PMID:
33074411
Article Published Date
: Oct 18, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Berberine suppresses tumorigenicity of triple negative breast cancer cells.
Jan 30, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Cell Physiol Biochem. 2018 Jan 31 ;45(2):795-807. Epub 2018 Jan 31. PMID:
29414799
Article Published Date
: Jan 30, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Berberine
Diseases
:
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Beta-elemene inhibits tumor growth by downregulating the expression of uPA, uPAR, MMP-2, and MMP-9.
Jan 31, 2015
Click here to read the entire abstract
Pubmed Data
: Melanoma Res. 2015 Feb ;25(1):15-21. PMID:
25405459
Article Published Date
: Jan 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Beta-Elemene
Diseases
:
Cancer Metastasis
,
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Beta-elemene reduces the malignancy of non-small cell lung cancer.
Dec 31, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Front Oncol. 2021 ;11:571476. Epub 2021 May 7. PMID:
34026596
Article Published Date
: Dec 31, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Beta-Elemene
Diseases
:
Lung Cancer
Pharmacological Actions
:
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Bi-directional solid fermentation may enhance the efficacy of Huaier in MDA-MB-231 cells.
Mar 14, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Chin Med Assoc. 2018 Mar 15. Epub 2018 Mar 15. PMID:
29551488
Article Published Date
: Mar 14, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Huaier (Trametes robiniophila murr)
Diseases
:
Breast Cancer
,
Breast Cancer: Triple Negative
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Biochanin-A induces apoptosis and suppresses migration in FaDu human pharynx squamous carcinoma cells.
Oct 31, 2017
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2017 Nov ;38(5):2985-2992. Epub 2017 Sep 13. PMID:
28901495
Article Published Date
: Oct 31, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Biochanin A
Diseases
:
Head and Neck Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Antiproliferative
,
Apoptotic
,
Bcl-2 protein down-regulation
,
Bcl-xL down-regulation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Bisdemethoxycurcumin may have potential as a novel anti-metastasis agent for the treatment of human cervical cancer.
Jun 30, 2018
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2018 Jul ;38(7):3989-3997. PMID:
29970522
Article Published Date
: Jun 30, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Bisdemethoxycurcumin
Diseases
:
Cancer Metastasis
,
Cervical Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
Bisdemethoxycurcumin serves as a therapeutic medicine to suppress ovarian cancer.
Dec 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Sci Rep. 2016 ;6:28773. Epub 2016 Jun 28. PMID:
27349797
Article Published Date
: Dec 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Bisdemethoxycurcumin
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antioxidants
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
Additional Keywords
:
Dose Response
[+]
Bisdemethoxycurcumin suppresses human brain glioblastoma multiforme.
Jun 22, 2022
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2022 Jun 23. Epub 2022 Jun 23. PMID:
35735092
Article Published Date
: Jun 22, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Bisdemethoxycurcumin
Diseases
:
Glioblastoma Multiforme
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Bisdemethoxycurcumin suppresses human osteosarcoma U‑2 OS cell migration and invasion.
Nov 30, 2022
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2022 Dec ;48(6). Epub 2022 Oct 12. PMID:
36222295
Article Published Date
: Nov 30, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Bisdemethoxycurcumin
Diseases
:
Osteosarcoma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Caspase-9 Activation
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
[+]
Blackberry leaf extract contains phytonutrients that prevent wrinkle formation.
Oct 01, 2007
Click here to read the entire abstract
Pubmed Data
: Int J Cosmet Sci. 2007 Oct;29(5):411. PMID:
18489379
Article Published Date
: Oct 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Blackberry
Diseases
:
Aging Skin
Pharmacological Actions
:
Interleukin-1 alpha downregulation
,
Matrix metalloproteinase-1 (MMP-1) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Both curcumin and chokeberry extract may exhibit their anticancer potential by inducing apoptosis and inhibiting invasion by reducing MMP gene expression.
Sep 30, 2012
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2012 Oct ;28(4):1435-42. Epub 2012 Jul 27. PMID:
22842701
Article Published Date
: Sep 30, 2012
Study Type
: In Vitro Study
Additional Links
Substances
:
Chokeberry
,
Curcumin
,
Polyphenols
Diseases
:
Glioblastoma
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-14 (MMP-14) inhibitor
,
Matrix metalloproteinase-16 (MMP-16) inhibitor
,
Matrix metalloproteinase-17 (MMP-17) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Bufalin inhibits gastric cancer invasion and metastasis.
May 03, 2018
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Oncotarget. 2018 May 4 ;9(34):23320-23333. Epub 2018 Jan 11. PMID:
29805736
Article Published Date
: May 03, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Bufalin
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells.
Dec 31, 2014
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2015 Jan ;30(1):74-82. Epub 2013 Aug 16. PMID:
23949904
Article Published Date
: Dec 31, 2014
Study Type
: In Vitro Study
Additional Links
Substances
:
Bufalin
Diseases
:
Cancer Metastasis
,
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antineoplastic Agents
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
,
NF-kappaB Inhibitor
[+]
C. officinalis flowers can be used as a natural source of antimelanogenisis and antimigration regent to treatment or prevent skin diseases.
Nov 27, 2018
Click here to read the entire abstract
Pubmed Data
: Photochem Photobiol. 2018 Nov 28. Epub 2018 Nov 28. PMID:
30609059
Article Published Date
: Nov 27, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Marigold
Diseases
:
Melanoma
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Dose Response
[+]
Capsaicin plays a chemo-modulatory and anti-cancer role working against experimentally induced lung carcinogenesis.
May 31, 2015
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Pharmacopuncture. 2015 Jun ;18(2):19-25. PMID:
26120484
Article Published Date
: May 31, 2015
Study Type
: In Vitro Study
Additional Links
Substances
:
Capsaicin
Diseases
:
Lung Cancer
Pharmacological Actions
:
Chemopreventive
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Cardamonin suppressed the migration, invasion, epithelial mesenchymal transition (EMT) and lung metastasis of colorectal cancer.
Nov 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Pharm Biol. 2022 Dec ;60(1):1011-1021. PMID:
35645356
Article Published Date
: Nov 30, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Cardamonin
Diseases
:
Cancer Metastasis
,
Colorectal Cancer
,
Lung Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Carthamus tinctorius L may potentially serve as a cardio-protective agent against LPS- induced cardiac fibrosis.
Feb 28, 2017
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2017 Mar ;32(3):754-763. Epub 2016 Apr 20. PMID:
27098997
Article Published Date
: Feb 28, 2017
Study Type
: In Vitro Study
Additional Links
Substances
:
Safflower
Diseases
:
Fibrosis
,
Lipopolysaccharide-Induced Toxicity
Pharmacological Actions
:
Cardioprotective
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Celastrol inhibits the proliferation and induces apoptosis of colorectal cancer cells.
Nov 01, 2021
Click here to read the entire abstract
Pubmed Data
: Anticancer Agents Med Chem. 2021 Nov 2. Epub 2021 Nov 2. PMID:
34732120
Article Published Date
: Nov 01, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Celastrol
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Cell cycle arrest
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review.
Jan 31, 2019
Click here to read the entire abstract
Pubmed Data
: Phytother Res. 2019 Feb ;33(2):263-275. Epub 2018 Nov 7. PMID:
30402931
Article Published Date
: Jan 31, 2019
Study Type
: Review
Additional Links
Substances
:
Kaempferol
Diseases
:
Cancers: All
,
Cervical Cancer
Pharmacological Actions
:
Anti-metastatic
,
Cell cycle arrest
,
Chemopreventive
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Chemopreventive and antitumor effects of benzyl isothiocynate on liver cancer.
Sep 10, 2018
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2018 Sep 11 ;108:65-75. Epub 2018 Sep 11. PMID:
30216802
Article Published Date
: Sep 10, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Benzyl isothiocyanate
Diseases
:
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Chemopreventive
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Vascular Endothelial Growth Factor Inhibitors
[+]
Chemopreventive properties of spent hops (Humulus Lupulus L.) extract against angiogenesis, invasion and migration of colorectal cancer.
May 31, 2022
Click here to read the entire abstract
Pubmed Data
: J Physiol Pharmacol. 2022 Jun ;73(3). Epub 2022 Dec 11. PMID:
36515626
Article Published Date
: May 31, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Hops
Diseases
:
Colorectal Cancer
Pharmacological Actions
:
Angiogenesis Inhibitors
,
Anti-metastatic
,
Chemopreventive
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Chlorogenic acid inhibition of esophageal squamous cell carcinoma metastasis.
Jun 30, 2022
Click here to read the entire abstract
Pubmed Data
: Anticancer Res. 2022 Jul ;42(7):3389-3402. PMID:
35790282
Article Published Date
: Jun 30, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Chlorogenic Acid
Diseases
:
Cancer Metastasis
,
Esophageal Cancer
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Chlorogenic-induced inhibition of non-small cancer cells occurs through regulation of histone deacetylase 6.
Jul 29, 2018
Click here to read the entire abstract
Pubmed Data
: Cell Mol Biol (Noisy-le-grand). 2018 Jul 30 ;64(10):134-139. Epub 2018 Jul 30. PMID:
30084806
Article Published Date
: Jul 29, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Chlorogenic Acid
Diseases
:
Carcinoma: Non-Small-Cell Lung
,
Lung Cancer
Pharmacological Actions
:
Antineoplastic Agents
,
Antiproliferative
,
Enzyme Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
[+]
Chrysanthemum indicum ethanolic extract inhibits invasion of hepatocellular carcinoma.
Jan 31, 2010
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2010 Feb ;23(2):413-21. PMID:
20043102
Article Published Date
: Jan 31, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Chrysanthemum Indicum
Diseases
:
Cancer Metastasis
,
Liver Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Chrysin inhibit human melanoma A375.S2 cell migration and invasion.
Mar 31, 2019
Click here to read the entire abstract
Pubmed Data
: Environ Toxicol. 2019 Apr ;34(4):434-442. Epub 2018 Dec 22. PMID:
30578657
Article Published Date
: Mar 31, 2019
Study Type
: In Vitro Study
Additional Links
Substances
:
Chrysin
Diseases
:
Cancer Metastasis
,
Melanoma
,
Skin Cancer
Pharmacological Actions
:
Anti-metastatic
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
NF-kappaB Inhibitor
[+]
Chrysin inhibits high glucose-induced migration on chorioretinal endothelial cells.
Aug 01, 2020
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Int J Mol Sci. 2020 Aug 2 ;21(15). Epub 2020 Aug 2. PMID:
32748894
Article Published Date
: Aug 01, 2020
Study Type
: In Vitro Study
Additional Links
Substances
:
Chrysin
Diseases
:
Diabetic Retinopathy
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Renoprotective
,
Vascular Endothelial Growth Factor Inhibitors
,
Vascular Endothelial Growth Factor Regulator
[+]
Cinnamaldehyde downregulation of Sept9 inhibits glioma progression.
Dec 31, 2021
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Dis Markers. 2022 ;2022:6530934. Epub 2022 Jan 19. PMID:
35096204
Article Published Date
: Dec 31, 2021
Study Type
: In Vitro Study
Additional Links
Substances
:
Cinnamaldehyde
Diseases
:
Glioma
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Clitoria ternatea flower petals: Effect on TNFR1 neutralization via downregulation of synovial matrix metalloproteases.
Jan 09, 2018
Click here to read the entire abstract
Pubmed Data
: J Ethnopharmacol. 2018 Jan 10 ;210:209-222. Epub 2017 Aug 19. PMID:
28826781
Article Published Date
: Jan 09, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Butterfly Pea
Diseases
:
Arthritis
,
Oxidative Stress
,
Rheumatoid Arthritis
Pharmacological Actions
:
Anti-Inflammatory Agents
,
Antioxidants
,
Cyclooxygenase 2 Inhibitors
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Plant Extracts
[+]
Co-treatment of tamoxifen and naringenin could inhibit cell proliferation more effectively in ER+ breast cancer cells.
Aug 24, 2018
Click here to read the entire abstract
Pubmed Data
: Toxicology. 2018 Aug 25. Epub 2018 Aug 25. PMID:
30153467
Article Published Date
: Aug 24, 2018
Study Type
: In Vitro Study
Additional Links
Substances
:
Naringenin
Diseases
:
Breast Cancer
Pharmacological Actions
:
Antiproliferative
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
Additional Keywords
:
Synergy with Tamoxifen
[+]
Cocoa catechins and procyanidins are cytotoxic to epithelial ovarian cancer cells.
Jun 23, 2016
Click here to read the entire abstract
Pubmed Data
: Biomed Pharmacother. 2016 Jun 24 ;83:130-140. Epub 2016 Jun 24. PMID:
27470560
Article Published Date
: Jun 23, 2016
Study Type
: In Vitro Study
Additional Links
Substances
:
Cocoa
Diseases
:
Ovarian Cancer
Pharmacological Actions
:
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords
:
Dose Response
,
Plant Extracts
[+]
Cordycepin attenuates migration and invasion of HSC-4 oral squamous carcinoma cells.
Sep 30, 2022
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: J Dent Sci. 2022 Oct ;17(4):1677-1688. Epub 2022 Mar 20. PMID:
36299321
Article Published Date
: Sep 30, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Cordyceps Militaris
Diseases
:
Oral Cancer
,
Squamous cell carcinoma
Pharmacological Actions
:
Anti-metastatic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Cordycepin inhibits the proliferation and migration of human gastric cancer cells.
May 31, 2022
Click here to read the entire abstract
Pubmed Data
: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2022 Jun ;38(6):513-521. PMID:
35732609
Article Published Date
: May 31, 2022
Study Type
: In Vitro Study
Additional Links
Substances
:
Cordyceps Militaris
Diseases
:
Gastric Cancer
Pharmacological Actions
:
Anti-metastatic
,
Antiproliferative
,
Apoptotic
,
Matrix metalloproteinase-2 (MMP-2) inhibitor
,
Matrix metalloproteinase-9 (MMP-9) inhibitor
[+]
Crocin has therapeutic and preventive effects on cancer cell lines.
Dec 31, 2019
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Iran J Basic Med Sci. 2020 Jan ;23(1):3-12. PMID:
32405344
Article Published Date
: Dec 31, 2019
Study Type
: Review
Additional Links
Substances
:
Crocin
Diseases
:
Breast Cancer
,
Colorectal Cancer
,
Leukemia: Chronic myelogenous leukemia (CML)
,