Matrix metalloproteinase-3 (MMP-3) inhibitor

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74 Substances Researched for Matrix metalloproteinase-3 (MMP-3) inhibitor

Name	AC	CK
Flavonoids	9	21
Curcumin	7	19
Frankincense	2	11
Coenzyme Q10	1	10
Strawberry	1	10
Vitamin K2	1	10
Vitamin K2: Menaquinone-7	1	10
Dogwood	3	6
Oleuropein	1	5
Sesamin	1	5
Vitexins	1	5
Apigenin	2	4
Berberine	3	4
Tetrahydrocurcumin	2	4
Turmeric	3	4
Wogonin	3	4
Astaxanthin	2	3
Caffeic acid phenethyl ester	2	3
Emodin	2	3
Krill	1	3
Silibinin	2	3
Arctigenin	2	2
Artesunate	1	2
Carnosic Acid	1	2
Ferulic acid	1	2
Fisetin	1	2
Ginkgo biloba	1	2
Ginsenosides	1	2
Honokiol	1	2
Isoliquiritigenin	1	2
Kaempferia parviflora	1	2
Mulberry	1	2
Myricetin	2	2
Nobiletin	1	2
Oleocanthal	1	2
Olive Oil	1	2
Oridonin	2	2
Paeoniflorin	1	2
Pineapple	1	2
Polyphenols	1	2
Puerarin	1	2
Quercetin	1	2
Saffron	1	2
Tamarind	1	2
Terminalia chebula	2	2
Vinegar	1	2
strawbrries	1	2
Avocado	1	1
Baicalein	1	1
Black Tea	1	1
Carvacrol	1	1
Cyanidin	1	1
Dandelion	1	1
Diosmin	1	1
Fucoidan	1	1
Genipin	1	1
Glycyrrhiza uralensis	1	1
Guduchi	1	1
Gynostemma	1	1
Hesperidin	1	1
Icariin	1	1
Kaempferol	1	1
Lactoferrin	1	1
Lupeol	1	1
Peony	1	1
Raspberry	1	1
Red Clover	1	1
Seaweed: Brown	1	1
Shitake Mushroom	1	1
Soybean: Black	1	1
Theaflavins	1	1
Thymoquinone	1	1
Vitamin C	1	1
Vitex negundo	1	1

Research Articles 102
Cumulative Knowledge Score 165
Overall Research Rating GOOD

View the Evidence:
102 Abstracts with Matrix metalloproteinase-3 (MMP-3) inhibitor Research

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View the Evidence: 102 Abstracts with Matrix metalloproteinase-3 (MMP-3) inhibitor Research

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Aflapin exhibited better efficacy compared to 5-Loxin to reduce pain and improve physical functions significantly in OA subjects.Dec 31, 2009

Coenzyme Q10 may provide a new complementary approach for rheumatoid arthritis patients.Aug 06, 2019

Curcumin suppresses inflammation in the mucosa of children and adults with inflammatory bowel disease. Nov 02, 2009

Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee osteoarthritis.Aug 27, 2017

Electroacupuncture ameliorates knee osteoarthritis.Aug 11, 2024

The oral intake of Pycnogenol down-regulated the gene expression of various cartilage degradation markers in the patients' chondrocytes.Dec 15, 2017

These results suggest that menaquinone-7 improves disease activity in patients with rheumatoid arthritis.Aug 14, 2015

Vitamin K2 improves disease activity in rheumatoid arthritis. Nov 05, 2012

Oleuropein might provide a basis for developing a new dietary strategy for the prevention and management of rheumatoid arthritis.Apr 19, 2017

Sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes.Dec 12, 2016

Vitexin alleviates interleukin-1β induced inflammatory responses in chondrocytes from osteoarthritis patients.May 03, 2019

Krill oil supplementation may help prevent osteoarthritis progression.Feb 28, 2022

A blend of Tamarindus indica and Curcuma longa extracts alleviates osteoarthritic pain and joint inflammation.May 23, 2023

Acacetin alleviates inflammation and matrix degradation in nucleus pulposus cells and ameliorates intervertebral disc degeneration.Dec 31, 2019

Acacetin suppresses IL-1 β-induced expression of matrix metalloproteinases in chondrocytes and protects against osteoarthritis.Dec 31, 2019

Acupoint electroacupuncture intervention can significantly alleviate the inflammatory reaction of adjuvant arthritis.Dec 13, 1901

Ameliorative effects of loganin on arthritis in chondrocytes.Feb 07, 2021

Antiosteoarthritic effect of morroniside in chondrocyte inflammation and destabilization of medial meniscus-induced mouse model.Mar 14, 2021

Apigenin can regulate the gene expression, secretion, and activity of MMP-3, by directly acting on articular chondrocytes.Feb 29, 2016

Apigenin inhibits the progression of osteoarthritis.Mar 23, 2023

Apoptosis and metastasis inhibitory potential of pineapple vinegar against mouse mammary gland cells.Dec 31, 2018

Aqueous extracts of Morus alba root bark and Cornus officinalis fruit protect against osteoarthritis symptoms.Dec 20, 2020

Artesunate may be of value as a therapeutic agent for osteoarthritis.Sep 30, 2019

Astaxanthin ameliorates cartilage damage in experimental osteoarthritis.Aug 31, 2015

Astragalin suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis.Dec 31, 2018

Caffeic acid phenethyl ester mitigates infertility: A crucial role of metalloproteinase and angiogenic factor in cadmium-induced testicular damage.Nov 16, 2021

Curcumin alleviates matrix metalloproteinases associated with inflammation during eradication of H. pylori infection.Jan 01, 2011

Curcumin suppresses type II collagen-induced arthritis in mice.Sep 01, 2009

Dietary oleocanthal supplementation prevents inflammation and oxidative stress in collagen-induced arthritis.Apr 22, 2021

Effect of photobiomodulation therapy on the proliferation phase and wound healing in rats fed with an experimental hypoproteic diet.Nov 05, 2020

Effect of silibinin on the expression of MMP2, MMP3, MMP9 and TIMP2 in kidney and lung after hepatic ischemia/reperfusion injury.Dec 31, 2020

Emodin protects knee joint cartilage.Mar 14, 2021

Extra virgin olive oil is a beneficial functional food exerting a preventive/palliative role in the management of systemic lupus erythematosus.Dec 31, 2015

F. nubicola possessed anti-arthritic properties that might be attributed to the amelioration of MMPs and pro-inflammatory cytokines.Oct 29, 2023

Ferulic acid may be a potential therapy for osteoarthritis.Jun 01, 2021

Fisetin may be a potential agent in the treatment of osteoarthritis.Feb 13, 2017

Ginkgo biloba extract may reduce MMP-3 production during IL-1β-induced chondrocyte damage and protect chondrocytes to some extent.Dec 31, 2014

Honokiol alleviates the degeneration of intervertebral disc.May 19, 2018

Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury.Mar 04, 2018

Notoginsenoside R1 facilitated wound healing in high-fat diet/streptozotocin-induced diabetic rats.Dec 31, 2021

Oral administration of black ginger extract significantly prevents UVB-induced photoaging in hairless mice.Sep 30, 2014

Paeoniflorin can significantly inhibit the pathology of adjuvant arthritis.Jun 30, 2018

Puerarin inhibits the development of osteoarthritis.Dec 21, 2020

Quercetin exerts chondroprotective effects.Jul 06, 2024

Rosemary derived carnosic acid is a promising natural compound for the treatment of rheumatoid arthritis.Jul 31, 2018

Saffron aqueous extract exerted dose-dependent anti-atherosclerotic and plaque-stabilizing effects in mice.Oct 31, 2017

Tetrahydrocurcumin and curcumin are effective for treating postmenopausal and osteoarthritis symptoms in ovariectomized rats.Dec 31, 2015

Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response.Oct 31, 2019

These data suggest that myricitrin could be developed as a potential therapy for osteoarthritis.Jun 30, 2020

These results show that the chondroprotective effects of wogonin are produced by its regulation of the gene expression.Aug 31, 2015

These results suggest a potential therapeutic role of isoliquiritigenin to treat osteoarthritis.Jun 14, 2018

This study provides the first evidence that nobiletin exert protection on endometriosis.Jun 04, 2018

Oridonin inhibits IL-1β-induced inflammation in human osteoarthritis chondrocytes by activating PPAR-γ.Mar 31, 2019

A standardized Terminalia chebula fruit extract alters the expression of genes associated with skin architecture and barrier formation.Oct 05, 2020

A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects.Mar 02, 2017

Acacetin inhibits expression of matrix metalloproteinases.Jul 31, 2015

Anti-osteoarthritic effects of an herbal composition LI73014F2 on interleukin-1β-induced primary human articular chondrocytes. Apr 26, 2020

Anti‑metastatic effects of arctigenin are regulated by MAPK/AP‑1 signaling in 4T‑1 mouse breast cancer cells.Feb 29, 2020

Arctigenin attenuates breast cancer progression.Sep 01, 2020

Ascorbic acid efficiently protected human chondrocytes against damage induced by H2O2 by regulating multiple regulatory pathways.Aug 19, 2015

Astaxanthin may be beneficial in the treatment of osteoarthritis.Feb 28, 2014

Baicalein inhibits IL-1β-induced extracellular matrix degradation with decreased MCP-1 expression in primary rat chondrocytes.Mar 31, 2024

Berberine inhibits RA-FLS cell proliferation and adhesion by regulating RAS/MAPK/FOXO/HIF-1 signal pathway in the treatment of rheumatoid arthritis.Jan 31, 2023

Berberine inhibits the interleukin-1 beta-induced inflammatory response via MAPK downregulation in rat articular chondrocytes.Apr 28, 2019

Black tea theaflavins represent promising multifunctional therapeutic agents for prevention and treatment of periodontal disease.Aug 22, 2016

Caffeic acid phenethyl ester attenuates osteoarthritis progression.Oct 31, 2022

Carvacrol may have potential therapeutic functions for the treatment of osteoarthritis.Feb 28, 2018

Chondroprotective effect of cynaroside in IL-1 β-induced primary rat chondrocytes and organ explants.Dec 31, 2019

Curcumin can be considered as a good lead compound in new inhibitors of MMP-3, which is a potential target of anticancer drugs.Dec 31, 2014

Curcumin might provide a novel therapeutic strategy for treating gliomas.Nov 18, 2005

Curcumoids inhibit matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells.Jul 01, 2010

Cyanidin-3-glucoside protects against high glucose-induced injury in human nucleus pulposus cells by regulating the Nrf2/HO-1 signaling.Dec 27, 2021

Matrix metalloproteinase-3 (MMP-3) inhibitor

View the Evidence:
102 Abstracts with Matrix metalloproteinase-3 (MMP-3) inhibitor Research