Neurogenesis

Name	AC	CK
Ginsenosides	1	20
Alpha-Lipoic Acid	1	10
Astragaloside	5	10
Curcumin	6	10
Echinacea	1	10
Linoleic acid	1	10
Bacopa	4	8
Psychedelics:All	3	6
Cannabinoids	4	5
Delta-tetrahydrocannabinol (THC)	4	5
Ginger	1	5
Cannabidiol	4	4
Ginkgo biloba	3	4
Ginseng (Korean)	2	4
Hesperidin	2	4
Moringa oleifera	2	4
Silibinin	2	4
Ursolic Acid	2	4
Goji	2	3
Psilocybin	2	3
Asiatic Acid	1	2
Astaxanthin	1	2
Berries: All	1	2
Bitter Orange	1	2
Chamomile	1	2
Cucurbitacin B	1	2
EGCG (Epigallocatechin gallate)	1	2
Gardenia	1	2
Gastrodin	1	2
Hydroxytyrosol	1	2
Hyperforin	1	2
Lactobacillus Brevis	1	2
Lavender: Essential Oil	1	2
Lemon Balm	1	2
Ligustrazine	1	2
Lion's Mane (Hericium Erinaceus)	1	2
Lotus	1	2
Luteolin	1	2
Lysergic Acid Diethylamide (LSD)	1	2
Magnolia	1	2
Magnolol	1	2
Melatonin	1	2
Omega-3 Fatty Acids	1	2
Paeoniflorin	1	2
Passion Flower	1	2
Prunella vulgaris	1	2
Reishi Mushroom	1	2
Resveratrol	2	2
Rose	1	2
Rosmarinic acid	1	2
Sea buckthorn	1	2
Sulforaphane	1	2
Thymoquinone	1	2
Turmeric	1	2
Turmerones	1	2
Vitamin D	1	2
Ayahuasca	1	1
Baicalein	1	1
Cannabis	1	1
Gotu Kola	1	1
Harmine	1	1
Panax Notoginseng	1	1
Salvia miltiorrhiza	1	1
Schisandra	1	1
Sesamin	1	1
Taurine	1	1
Walnut	1	1
Zinc	1	1

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Available findings demonstrated the preclinical evidence that Ginsenoside-Rb1 has a potential neuroprotective effects.Dec 31, 2019

5-MeO-DMT affects neurogenesis and this effect may contribute to the known antidepressant properties of DMT-derived compounds.Dec 31, 2017

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Pubmed Data : Front Mol Neurosci. 2018 ;11:312. Epub 2018 Sep 4. PMID: 30233313

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Psychedelics:All

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Neurogenesis

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A natural carotenoid crocin exerts antidepressant action.Dec 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J Neural Transm (Vienna). 2020 Jan 23. Epub 2020 Jan 23. PMID: 31974720

Article Published Date : Jan 22, 2020

Study Type : Animal Study

Additional Links

Diseases : Depression

Therapeutic Actions : Exercise

Pharmacological Actions : Antidepressive Agents, Neurogenesis, Neuroprotective Agents

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Aromatic turmerone constitutes a promising candidate to support regeneration in neurologic disease.Dec 31, 2013

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Pubmed Data : Stem Cell Res Ther. 2014 ;5(4):100. Epub 2014 Sep 26. PMID: 25928248

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Consuming grape seed extract in the elderly can potentially alleviate the age-related reduction of hippocampal neurogenesis and synaptogenesis.May 09, 2021

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Pubmed Data : Nutr Neurosci. 2021 May 10:1-11. Epub 2021 May 10. PMID: 33970818

Article Published Date : May 09, 2021

Study Type : Animal Study

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Substances : Grape Seed Extract

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

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Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice.Jun 29, 2019

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Pubmed Data : J Cell Mol Med. 2019 Jun 30. Epub 2019 Jun 30. PMID: 31257716

Article Published Date : Jun 29, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Memory Disorders

Pharmacological Actions : Neurogenesis

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Curcumin can stimulate developmental and adult hippocampal neurogenesis, and a biological activity that may enhance neural plasticity and repair.Dec 01, 2000

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Pubmed Data : J Clin Psychopharmacol. 2000 Dec;20(6):680-4. PMID: 18362141

Article Published Date : Dec 01, 2000

Study Type : Animal Study

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Substances : Curcumin

Diseases : Aging, Brain Injury: Hippocampal Damage

Pharmacological Actions : Antiproliferative , Neuritogenic, Neurogenesis

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Pubmed Data : FASEB J. 2020 Feb 6. Epub 2020 Feb 6. PMID: 32027412

Article Published Date : Feb 05, 2020

Study Type : Animal Study

Additional Links

Substances : Hydroxytyrosol

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

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Hyperforin promotes post-stroke neuroangiogenesis.Dec 31, 2018

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Pubmed Data : Neurosci Lett. 2019 05 14 ;701:180-192. Epub 2019 Feb 28. PMID: 30825591

Article Published Date : Jan 13, 2019

Study Type : Animal Study

Additional Links

Substances : Lavender: Essential Oil

Diseases : Anxiety, Depression

Pharmacological Actions : Anti-Anxiety Agents, Antidepressive Agents, Neurogenesis

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Pubmed Data : Phytother Res. 2016 Nov ;30(11):1856-1861. Epub 2016 Aug 11. PMID: 27510271

Article Published Date : Oct 31, 2016

Study Type : Animal Study

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Substances : Magnolol

Diseases : Depression

Pharmacological Actions : Antidepressive Agents, Neurogenesis

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Melatonin improved the depressive behaviour of stressed mice.Jul 10, 2016

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Pubmed Data : Phytomedicine. 2021 Jan 31 ;83:153490. Epub 2021 Jan 31. PMID: 33601255

Article Published Date : Jan 30, 2021

Study Type : Animal Study

Additional Links

Substances : Rosmarinic acid, Ursolic Acid

Diseases : Alzheimer's Disease

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

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Saffron, combined with endurance exercise, synergistically increased hippocampus BDNF, serotonin, and muscular neurotrophin-3 mRNA.Dec 31, 2020

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Pubmed Data : Rep Biochem Mol Biol. 2021 Jan ;9(4):426-434. PMID: 33969136

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Saffron

Diseases : Memory Disorders

Therapeutic Actions : Exercise

Pharmacological Actions : Brain-derived neurotrophic factor modulator, Neurogenesis

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Sea buckthorn extract treatment significantly increased cell proliferation and neuroblast differentiation in the aged gerbil dentate gyrus.Dec 31, 2013

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Pubmed Data : Chin Med J (Engl). 2014 ;127(23):4006-11. PMID: 25430440

Article Published Date : Dec 31, 2013

Study Type : Animal Study

Additional Links

Substances : Sea buckthorn

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Antioxidants, Neurogenesis, Superoxide Dismutase Up-regulation

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Tetramethylpyrazine promotes migration of neural precursor cells.Jan 10, 2016

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Pubmed Data : Mol Neurobiol. 2016 11 ;53(9):6526-6539. Epub 2015 Nov 28. PMID: 26614511

Article Published Date : Jan 10, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ligustrazine

Diseases : Middle Cerebral Artery Occlusion (MCAO)

Pharmacological Actions : Neurogenesis, Neuroprotective Agents

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The activation of the endocannabinoid system promotes white and gray matter recovery after neonatal HI injury.Nov 30, 2010

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Pubmed Data : Stroke. 2010 Dec ;41(12):2956-64. PMID: 21115947

Article Published Date : Nov 30, 2010

Study Type : Animal Study

Additional Links

Substances : Cannabinoids

Diseases : Brain Ischemia, Neonatal Stroke, Stroke: Attenuation/Recovery

Pharmacological Actions : Neurogenesis

Additional Keywords : Endocannabinoid System, Neuro-repair

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The benefits of voluntary physical exercise after traumatic brain injury on rat's object recognition memory.Jan 07, 2020

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Pubmed Data : Exp Neurol. 2017 Oct 19. Epub 2017 Oct 19. PMID: 29056360

Article Published Date : Oct 18, 2017

Study Type : Animal Study

Additional Links

Diseases : Stroke: Ischemic

Therapeutic Actions : Laser Treatment: Low-Level, Light-Emitting Diodes (LEDs) Therapy, Light Therapy

Pharmacological Actions : Anti-Inflammatory Agents, Neurogenesis

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Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2017 Dec 26. Epub 2017 Dec 26. PMID: 29277983

Article Published Date : Dec 25, 2017

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Pharmacological Actions : Neurogenesis

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Treadmill exercise alleviates Alzheimer disease-associated memory loss by increasing neurogenesis.Jul 31, 2016

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Pubmed Data : J Exerc Rehabil. 2016 Aug ;12(4):276-83. Epub 2016 Aug 31. PMID: 27656623

Article Published Date : Jul 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Alzheimer's Disease, Diabetic Complications

Therapeutic Actions : Exercise

Pharmacological Actions : Neurogenesis, Neuroprotective Agents, Wnt/β-catenin signaling pathway modulation

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Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta.Dec 31, 2021

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Pubmed Data : Curr Opin Psychiatry. 2022 Jan 1 ;35(1):22-29. PMID: 34855694

Article Published Date : Dec 31, 2021

Study Type : Review

Additional Links

Substances : Psychedelics:All

Diseases : Mood Disorders

Pharmacological Actions : Neurogenesis, Neuroplasticity enhancement

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Effects of Ginkgo biloba extract EGb761 on neural differentiation of stem cells offer new hope for neurological disease treatment.Jun 30, 2019

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Pubmed Data : Neural Regen Res. 2019 Jul ;14(7):1152-1157. PMID: 30804240

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Pubmed Data : Exp Ther Med. 2016 Aug ;12(2):683-689. Epub 2016 Jun 2. PMID: 27446261

The studies provide "proof of principle" that CBD and possibly CBD-THC combinations are valid candidates for novel AD therapies.Dec 31, 2016

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Pubmed Data : Front Pharmacol. 2017 ;8:20. Epub 2017 Feb 3. PMID: 28217094

Article Published Date : Dec 31, 2016

Study Type : Review

Additional Links

Substances : Cannabidiol, Delta-tetrahydrocannabinol (THC)

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neurogenesis, Neuroprotective Agents

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Therapeutic role of curcumin in adult neurogenesis for management of psychiatric and neurological disorders.Apr 27, 2022

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View the Evidence: 148 Abstracts with Neurogenesis Research

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Available findings demonstrated the preclinical evidence that Ginsenoside-Rb1 has a potential neuroprotective effects.Dec 31, 2019

Alpha-lipoic acid, linoleic acid and echinacea proved to be an effective treatment for controlling symptoms and improving the evolution of carpal tunnel syndrome.May 31, 2015

Indonesian ginger extract promotes neurogenesis of human neural stem cells.Jul 04, 2020

Protective effects of a polyphenol-rich blueberry extract on adult human neural progenitor cells.Sep 19, 2022

5-MeO-DMT affects neurogenesis and this effect may contribute to the known antidepressant properties of DMT-derived compounds.Dec 31, 2017

A natural carotenoid crocin exerts antidepressant action.Dec 31, 2022

Administration of THC was observed to enhance the neurogenesis in the brainSep 20, 2017

Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease.Jan 24, 2021

Antidepressant-like and pro-neurogenic effects of physical exercise: the putative role of FNDC5/irisin pathway.Jan 22, 2020

Aromatic turmerone constitutes a promising candidate to support regeneration in neurologic disease.Dec 31, 2013

Asiatic acid can enhance spatial memory after administration for 28 days.Oct 04, 2015

Astaxanthin supplementation enhanced adult hippocampal neurogenesis and spatial memory in mice. Dec 07, 2015

Astragaloside IV improves neurobehavior and promotes hippocampal neurogenesis.Jul 15, 2020

Astragaloside IV promotes adult neurogenesis in hippocampal dentate gyrus.Aug 28, 2018

Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis.Feb 28, 2021

Astragaloside IV stimulates hippocampal neurogenesis after stroke.Dec 31, 2019

Astragaloside VI could be a new therapeutic drug candidate for post-stroke treatment.Aug 06, 2018

Bacopa monnier ameliorated trimethyltin-induced cognitive disturbances.Dec 31, 2018

Bacopa monnieri extract exerted neuroprotective effects possibly by promoting hippocampal neurogenesis with elevation of BDNF level.Oct 31, 2016

Bacopa monnieri extract improves memory performance.May 08, 2020

Baicalin may promote hippocampal neurogenesis, thereby exerting the antidepressant effect.Jul 31, 2021

Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice.May 06, 2022

Brahmi is a potential cognitive enhancer against schizophrenia.Feb 28, 2015

Chronic administration of thymoquinone enhances adult hippocampal neurogenesis and improves memory.Dec 01, 2021

Chrysin loaded nanovesicles ameliorated diabetic peripheral neuropathy.Apr 24, 2023

Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation.Oct 31, 2018

Consuming grape seed extract in the elderly can potentially alleviate the age-related reduction of hippocampal neurogenesis and synaptogenesis.May 09, 2021

Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice.Jun 29, 2019

Curcumin can stimulate developmental and adult hippocampal neurogenesis, and a biological activity that may enhance neural plasticity and repair.Dec 01, 2000

Curcumin may protect from focal cerebral ischemia reperfusion injury as well as stimulate neurogenesis.May 31, 2016

Curcumin nanoparticles may offer a therapeutic approach to treating neurodegenerative diseases by enhancing brain self-repair mechanisms.Jan 27, 2014

Curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/β-catenin signaling pathway.May 11, 2015

Dietary heat-killed Lactobacillus brevis SBC8803 functions as memory and neurogenesis enhancers.May 31, 2019

DL-3-n-butylphthalide promotes hippocampal neurogenesis and reduces mossy fiber sprouting in chronic temporal lobe epilepsy.Jan 02, 2022

EGCG could have beneficial effects on neurogenesis and stroke recovery. May 19, 2016

Electroacupuncture alleviates SD-induced spatial memory impairment.Oct 07, 2021

Erinacine A and S reduce Alzheimer’s disease pathology via reducing amyloid deposition and promoting neurogenesis.Feb 16, 2018

Exercise delays cognitive decline by the enhancing neurogenesis and increasing BDNF expression in the context of vascular dementia.Mar 31, 2016

Exercise serves as a potential strategy to prevent the development of Alzheimer's disease by regulating adult neurogenesis and brain immune-activity.May 01, 2018

G. lucidum polysaccharides could serve as a regenerative agent for the treatment of cognitive decline associated with neurodegenerative diseases.Jan 09, 2017

Gastrodin improves hippocampal neurogenesis by NO-cGMP-PKG signaling pathway in cerebral ischemic mice.Nov 30, 2019

Gastrodin promotes hippocampal neurogenesis via PDE9-cGMP-PKG pathway in mice following cerebral ischemia.Aug 18, 2021

Gastrodin treatment markedly preserved the Wnt/β-Catenin signalling pathway, which could promote neurogenesis and provide neuroprotection brain injury.May 31, 2019

Ginsenoside Rg1 attenuation of neurogenesis disorder and neuronal apoptosis in the rat hippocampus after spinal cord injury.Mar 21, 2023

Harmine produces antidepressant-like effects via restoration of astrocytic functions.Oct 02, 2017

Hesperidin alleviates methotrexate-induced memory deficits via hippocampal neurogenesis in adult rats.Apr 24, 2019

Hydroxytyrosol stimulates neurogenesis in aged dentate gyrus by enhancing stem and progenitor cell proliferation and neuron survival.Feb 05, 2020

Hyperforin promotes post-stroke neuroangiogenesis.Dec 31, 2018

Improvement in neurogenesis and memory function by administration of Passiflora incarnata extract.Apr 01, 2019

Korean red ginseng promotes hippocampal neurogenesis in mice.Apr 30, 2020

Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats.Jan 13, 2019

Long-term administration of salvianolic acid A promotes endogenous neurogenesis in ischemic stroke.Feb 24, 2022

Long-term treadmill exercise could improve the spatial memory of the male APPswe/PS1dE9 AD mice.Oct 31, 2015

Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.Mar 31, 2019

Luteolin treatment ameliorates brain development and behavioral performance in a mouse model of CDKL5 deficiency disorder.Aug 04, 2022

Lycopene-loaded microemulsion attenuates cognitive impairment in Aβ-induced AD rats by promoting neurogenesis.Dec 31, 2020

Magnolol exerts antidepressant-like effects on behaviours by enhancing hippocampal neurogenesis.Oct 31, 2016

Melatonin improved the depressive behaviour of stressed mice.Jul 10, 2016

Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a model of Alzheimer's disease.Aug 31, 2019

Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury.Nov 30, 2023

Moringa oleifera seed extract protects against brain damage in both the acute and delayed stages of ischemic stroke.Jul 14, 2019

N. nucifera extract is the potential neuroprotective and memory enhancing agent. Dec 31, 2015

Neurogenesis and proliferation of neural stem/progenitor cells conferred by artesunate.May 20, 2022

Neurogenesis in the rat neonate's hippocampus with maternal short-term REM sleep deprivation restores by royal jelly treatment.Nov 21, 2021

Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress.Jun 05, 2020

Neuroprotective role of dietary supplementation with omega-3 fatty acids.Mar 03, 2020

Nobiletin mitigates D-galactose-induced memory impairment.May 07, 2023

Notoginsenoside R1 improves cerebral ischemia/reperfusion injury by promoting neurogenesis.Dec 31, 2020

Photobiomodulation regulates adult neurogenesis in the hippocampus in a status epilepticus animal model.Sep 08, 2022

Physical exercise ameliorates the reduction of neural stem cell, cell proliferation and neuroblast differentiation in senescent mice.Oct 30, 2014

Physical exercise rescues defective neural stem cells.Feb 27, 2017

Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions.Nov 08, 2019

Neurogenesis

View the Evidence:
148 Abstracts with Neurogenesis Research