Neuroprotective Agents

Name	AC	CK
Curcumin	206	354
Ginsenosides	105	194
Ginkgo biloba	43	166
Resveratrol	94	163
Melatonin	73	158
Cannabidiol	73	148
Huperzine	37	138
Blueberry	31	125
Cannabinoids	43	88
Puerarin	42	88
Astaxanthin	48	85
Vitamin C	37	82
Thymoquinone	46	80
Alpha-Lipoic Acid	25	78
EGCG (Epigallocatechin gallate)	39	76
Folic Acid	18	72
Bacopa	35	69
Flavonoids	36	68
Omega-3 Fatty Acids	16	68
Sulforaphane	32	63
Lutein	7	62
Coenzyme Q10	24	60
Vitamin D	12	60
Polyphenols	29	59
Quercetin	28	57
Tanshinone IIA	34	55
Berberine	30	52
Gastrodin	28	51
Zeaxanthin	5	50
Probiotics	14	49
Palmitoylethanolamide	22	47
Vitamin B-12	8	46
Delta-tetrahydrocannabinol (THC)	20	44
Cannabis	17	43
EPA (Eicosapentaenoic Acid)	4	42
Gotu Kola	21	42
Nigella sativa (aka Black Seed)	23	42
Olive Oil	12	40
Ligustrazine	10	38
Valerian	8	38
Vitamin B-6	7	38
Anthocyanins	19	37
Pomegranate	16	37
Selenium	15	37
DHA (Docosahexaenoic Acid)	11	35
Green Tea	22	34
Catechin	21	33
Citrus naringin	8	33
Strawberry	10	33
Vitamin E	13	33
Ashwagandha	13	32
Coconut Oil	10	31
Nuts	4	31
Paeoniflorin	18	31
Panax Notoginseng	13	31
Genistein	17	30
Saffron	14	30
Naringenin	18	29
Nobiletin	16	29
Rose	12	29
Fucoidan	18	28
Grape Seed Extract	14	28
Asiatic Acid	16	27
Frankincense	11	27
Ginger	16	27
Grape	10	27
Luteolin	18	27
Piperine	14	27
Fisetin	16	26
Apigenin	12	25
Hesperidin	13	25
Pycnogenol (Pine Bark)	5	25
Sage	6	25
Turmeric	17	25
Lemon Balm	5	24
Magnesium	9	24
Thiamine (B-1)	4	24
Astragaloside	17	23
Goji	10	23
Hydrogen Water	12	23
Sesamol	12	23
Berries: All	4	22
Black Currant	3	22
Chlorogenic Acid	8	22
Crocin	12	22
Ellagic Acid	12	22
Holy Basil	6	21
Sesamin	7	21
St. Johns Wort	7	21
Walnut	12	21
Baicalein	12	20
Chocolate	2	20
Rosemary	7	20
Spirulina	12	20
Ginseng (Korean)	10	19
Honokiol	11	19
Rosmarinic acid	10	19
Bee Venom	5	18
Black Tea	6	18
Royal Jelly	10	18
Testosterone	6	18
Almond	5	17
Cinnamon	6	17
Moringa oleifera	9	17
Persimmon	11	17
Vitamin E: alpha tocopherol	5	17
Ferulic acid	11	16
Garlic	10	16
Lycopene	9	16
Rutin	9	16
Ubiquinol	4	16
Broccoli Sprouts	4	15
Chrysin	8	15
Lingonberry	4	15
Lotus	9	15
Mucuna pruriens (aka Velvet Beans)	8	15
Myricetin	9	15
Oleuropein	11	15
Progesterone	4	15
Pterostilbene	11	15
Tetrahydrocurcumin	8	15
Acetyl-l-carnitine	3	14
Antioxidant formulas	5	14
Caffeic acid phenethyl ester	8	14
Coffee	5	14
Diosgenin	3	14
Ginseng	8	14
Gynostemma	9	14
Hemp Seed	3	14
Kaempferol	3	14
Lion's Mane (Hericium Erinaceus)	8	14
Purslane	7	14
Reishi Mushroom	9	14
Stilbenes	10	14
Verbascoside	8	14
Black Pepper	7	13
Carotenoids	3	13
Estradiol (E(2))	8	13
Multivitamin	2	13
Phloretin	5	13
Allicin	7	12
Beta-Caryophyllene	8	12
Caffeine	8	12
Cannabinoids: Synthetic	3	12
Carnosic Acid	8	12
Fucoxanthin	8	12
Mangiferin	8	12
Phosphatidylserine	2	12
Red Wine Extract	3	12
Sea buckthorn	2	12
Spearmint	2	12
Spikenard	7	12
Taurine	7	12
Vitamin B-3 (Niacin)	2	12
Citrus Peel	6	11
Hyperforin	6	11
Isothiocyanates	2	11
Magnolol	6	11
NAC (N-acetyl-L-cysteine)	7	11
Vitexins	8	11
Bamboo	6	10
Bergamot orange	1	10
Blue Honeysuckle	1	10
Curry Spice	1	10
Papaya: Fermented	1	10
Peanut	1	10
Silibinin	5	10
Sweet Potato: Purple	5	10
Tomato	1	10
Ursolic Acid	5	10
Vegetables: All	1	10
Yam	1	10
6-Shogaol	6	9
Fenugreek	5	9
Hydroxytyrosol	6	9
Rosemaric Acid	5	9
Spinach	5	9
Tangeretin	6	9
Theanine	6	9
Vanillin	5	9
Arctigenin	5	8
Betulinic acid	4	8
Geraniol	5	8
Gingerol	4	8
Glycoaminoglycans	4	8
Lychee	5	8
Olive leaf extract	4	8
Red Sage	4	8
Syrian rue	4	8
Thymol	4	8
Xanthohumol	5	8
Acai	4	7
Brown Rice: Pre-Germinated	2	7
Chinese Skullcap	5	7
Chrysanthemum Indicum	4	7
Demethoxycurcumin	4	7
Gallic Acid	4	7
Hibiscus sabdariffa	4	7
Insulin-like Growth Factor (IGF-1)	4	7
Isoliquiritigenin	5	7
Lignans	5	7
Long Pepper	4	7
Mulberry	4	7
Oleocanthal	2	7
Passion Flower	4	7
Perilla	5	7
Piceatannol	6	7
Safranal	4	7
Acorus calamus	3	6
Amla Fruit	4	6
Bifidobacterium Longum	3	6
Bilberry	3	6
Carnosine	4	6
Carvacrol	3	6
Cranberry	4	6
Dandelion	5	6
Dates	3	6
Diosmin	3	6
Fermented Foods and Beverages	4	6
Hops	3	6
Icariin	4	6
Kimchi	3	6
Lavender: Essential Oil	3	6
Melanin: Bacterial	3	6
Nettle	3	6
Noni	3	6
P-Coumaric Acid	3	6
Palash	3	6
Psychedelics:All	3	6
Rooibos	3	6
Salvia divinorum	3	6
Amurensin G	1	5
Antrodia camphorata	3	5
Asparagus	3	5
Bee Propolis	3	5
Blackberry	3	5
Bromelain	1	5
Carnosol	3	5
Chokeberry	4	5
Cordyceps sinensis	3	5
Coriandrum sativum	3	5
Coumestrol	3	5
Endocannabinoids	4	5
Eugenol	3	5
Glycyrrhizin	3	5
Guarana	3	5
Isoflavones	4	5
Lithium	3	5
Nicotinamide adenine dinucleotide (NADH)	3	5
Parthenolide	3	5
Prickly Pear Cactus	3	5
Punicalagin	4	5
Salvia miltiorrhiza	3	5
Tea	3	5
Turmerones	3	5
Zataria multiflora	3	5
Anise	2	4
Apocynin	2	4
Apples	2	4
Arginine	2	4
B-complex	2	4
Crocetin	2	4
Curcuminoids	3	4
Daidzein	3	4
Date Seeds	2	4
Dill	2	4
Emodin	2	4
Epicatechin	2	4
False Black Pepper	2	4
Fig	2	4
Flaxseed	2	4
Folate	2	4
Ginseng (American)	2	4
Gold (nanoparticles)	2	4
Hawthorn	3	4
Kefir	2	4
Kudzu	3	4
Lactobacillus Acidophilus	2	4
Lactobacillus helveticus	2	4
Linden (Tilia)	2	4
Olive	3	4
Onion	2	4
Panax Ginseng	4	4
Parsley	2	4
Plum	2	4
Pomegranate Peel	2	4
Prunella vulgaris	2	4
Radish	2	4
Raisins	2	4
Rehmannia	2	4
Rice Bran	2	4
S-Adenosylmethionine (SAMe)	3	4
Soy	2	4
Soy Sauce	2	4
Tauroursodeoxycholic acid	3	4
Tribulus	2	4
Vitamin B12: methylcobalamin	4	4
White Tea	3	4
Wogonin	2	4
Agaricus Blazei	2	3
Bael	2	3
Barberry	2	3
Bay leaf	2	3
Beet	2	3
Bitter Orange	2	3
Butyrate	2	3
Carob	2	3
Celery	2	3
Chaga Mushroom (Inonotus obliquus)	2	3
Coconut	2	3
Cordyceps Militaris	2	3
Genipin	2	3
Glycyrrhiza uralensis	2	3
Indole-3-Carbinol	2	3
Japanese cypress	2	3
Lettuce	2	3
Licorice	3	3
Mangosteen	3	3
Nattokinase	2	3
Neem	2	3
Orange: Mandarin	2	3
Polyunsaturated Fatty Acids (PUFAs)	3	3
Procyanidin B2	2	3
Pueraria mirifica	2	3
Riboflavin (Vitamin B-2)	2	3
Schisandra	2	3
Silymarin	2	3
Urolithin A	2	3
Vitex negundo	2	3
White Mulberry	2	3
Yellow Sweet Clover (Melilotus officinalis)	2	3
African Basil	1	2
Aloe Vera	1	2
Andrographolide	1	2
Anemarrhena asphodeloides	1	2
Angelica	1	2
Apple Polyphenols	1	2
Artesunate	1	2
Astragalus	1	2
Ayahuasca	2	2
Baccharis trimera	1	2
Basil	1	2
Bee Pollen	1	2
Beta Sitosterol	1	2
Beta-Elemene	1	2
Beta-glucan	1	2
Bifidobacterium Bifidum	1	2
Bifidobacterium Breve	1	2
Bifidobacterium Lactis	1	2
Bloodroot	1	2
Boron	2	2
Broccoli	1	2
Buckwheat	1	2
Burdock	2	2
Caffeoylquinic Acids	1	2
Capparis spinosa (caper)	1	2
Capsaicin	1	2
Carnitine	1	2
Carpolobia lutea	1	2
Carrot	1	2
Cashew	1	2
Choline	1	2
Cilantro	1	2
Cinnamaldehyde	2	2
Cocoa	2	2
Combretum fragrans	1	2
Coptis chinensis	1	2
Corn: Purple	1	2
Creatine	1	2
Cryptoxanthin	1	2
Curcuma Longa	1	2
Cysteine (see N-Acetylcysteine)	2	2
D-Limonene	1	2
DHEA (Dehydroepiandrosterone)	1	2
Dopa bean	1	2
Echinacea	2	2
Elderberry	2	2
Eleutherococcus senticosus	1	2
Embelia ribes	1	2
Essential Oils: Unspecified	1	2
Estriol	2	2
FOS (Fructooligosaccharides)	1	2
Flaxseed Oil	1	2
Fruit: All	1	2
Glandulars	1	2
Glucosamine	1	2
Glutathione	2	2
Grapefruit Seed Extract	1	2
Green Coffee Bean	1	2
Grewia Asiatica	1	2
Gymnema Sylvestre	1	2
Hibiscus	1	2
Hibiscus rosa-sinensis	1	2
Jujube	1	2
Kaempferia parviflora	1	2
Kava Kava	2	2
Kiwifruit	1	2
Krill	1	2
Lactobacillus fermentum	1	2
Lactobacillus plantarum	1	2
Lactobacillus probiotics	1	2
Lactobacillus rhamnosus	1	2
Lauric acid	2	2
Lavender	1	2
Loquat	1	2
Lupeol	1	2
Lysine	1	2
Magnesium Sulfate	1	2
Maitake Mushroom	1	2
Manganese	1	2
Mango	1	2
Mango leaf	1	2
Moxibustion	1	2
Mushrooms: All	2	2
Muskmelon	1	2
Myrrh	1	2
Myrtle	1	2
Nordihydroguaiaretic acid (NDGA)	1	2
OPC (Oligomeric Proanthocyanidins)	1	2
Octacosanol	1	2
Oleanolic acid	1	2
Peppermint	1	2
Perillaldehyde	1	2
Pine Needle	1	2
Piperidines	1	2
Piperlongumine	1	2
Placenta Extract (or Stem Cells)	1	2
Propolis: Bee	1	2
Pumpkin	1	2
Pyruvate	1	2
Red Clover	1	2
Rhubarb	1	2
Rose Hips	1	2
SAMe (S-adenosylmethionine)	1	2
Seaweed: Brown	1	2
Skullcap: Chinese	1	2
Soy Protein	1	2
Sweet Potato	1	2
Tart Cherry	1	2
Tocotrienol: Delta	1	2
Tualang Honey	1	2
Turmeric: Fermented	1	2
Ume (Japanese apricot)	1	2
Vinegar	1	2
Virgin Coconut Oil	1	2
Water: Deuterium Depleted	1	2
White Button Mushroom	1	2
Xanthones	2	2
Yeast	1	2
Yerba Mate	1	2
Ziziphus spinosa	2	2
magnesium chloride	1	2
phytoestrogens	1	2
18β-Glycyrrhetinic Acid	1	1
2,3,5,4'-tetrahydroxystilbene-2-O-β -D-glucoside (THSG)	1	1
ALA (Alpha-Linolenic Acid)	1	1
Achillea fragrantissima	1	1
Achiote	1	1
Alpha Linolenic Acid	1	1
Alpha-naphthoflavone	1	1
Alpinia galanga	1	1
Anandamide	1	1
Arachidonic Acid	1	1
Avocado	1	1
Bioflavonoids	1	1
Black Raspberry	1	1
Black Tea Theaflavins	1	1
Boerhaavia diffusa	1	1
Brussel sprouts	1	1
Cardamom	1	1
Chaenomeles speciosa	1	1
Chili pepper	1	1
Clove	1	1
Colostrum	1	1
Coriandor	1	1
Corn Silk	1	1
Cucurbitacin E	1	1
Cumin	1	1
Cyanidin	1	1
Fiber	1	1
Garcinia Mangostana	1	1
Garlic: Aged	1	1
Gc protein-derived macrophage activating factor (GcMAF)	1	1
Guava	1	1
Guduchi	1	1
Haritaki (Terminalia chebula)	1	1
Hazelnut	1	1
Honey	1	1
Isoquercitrin	1	1
Isothiocyanate	1	1
Knema laurina	1	1
Lemon Verbena	1	1
Maple Syrup	1	1
Marijuana	1	1
Medicinal Mushrooms	1	1
Mistletoe	1	1
Patchouli	1	1
Phellinus Linteus	1	1
Phytate	1	1
Pine Bark Extract	1	1

[+]

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Pubmed Data : Medicine (Baltimore). 2020 Jan ;99(2):e18568. PMID: 31914035

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Pubmed Data : Evid Based Complement Alternat Med. 2014 ;2014:363985. Epub 2014 Feb 3. PMID: 24639880

Article Published Date : Dec 31, 2013

Study Type : Meta Analysis

Additional Links

Substances : Huperzine

Diseases : Alzheimer's Disease, Dementia

Pharmacological Actions : Neuroprotective Agents

[+]

Hyperbaric oxygen therapy had a neuro-protective effect and improved survival in animal models of MCAO.Dec 31, 2015

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Pubmed Data : J Neurotrauma. 2018 Jun 14. Epub 2018 Jun 14. PMID: 29901413

Article Published Date : Jun 13, 2018

Study Type : Meta Analysis, Review

Additional Links

Substances : Melatonin

Diseases : Brain Injury: Traumatic

Pharmacological Actions : Neuroprotective Agents

[+]

These findings further guide the therapeutic strategy for clinical cerebral ischemic stroke.Dec 31, 2019

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Pubmed Data : Zhongguo Zhen Jiu. 2017 Oct 12 ;37(10):1119-25. PMID: 29354984

Article Published Date : Oct 11, 2017

Study Type : Meta Analysis, Review

Additional Links

Diseases : Stroke: Attenuation/Recovery

Therapeutic Actions : Electroacupuncture

Pharmacological Actions : Neuroprotective Agents

[+]

This meta-analysis suggests that physical activity interventions positively influence cognitive function in patients with dementia.Dec 31, 2015

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Pubmed Data : Ageing Res Rev. 2016 Jan ;25:13-23. Epub 2015 Nov 28. PMID: 26607411

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Pubmed Data : Nutrients. 2018 May 23 ;10(6). Epub 2018 May 23. PMID: 29882843

[+]

A single bout of aerobic exercise improves motor skill consolidation in Parkinson's disease.Dec 31, 2017

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Pubmed Data : Front Aging Neurosci. 2018 ;10:328. Epub 2018 Oct 22. PMID: 30405397

Article Published Date : Dec 31, 2017

Study Type : Human Study

Additional Links

Diseases : Parkinson's Disease

Therapeutic Actions : Exercise: Aerobic, Exercise: Cycling

Pharmacological Actions : Neuroprotective Agents

[+]

A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis.Dec 31, 2017

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Pubmed Data : J Neurol Neurosurg Psychiatry. 2018 04 ;89(4):330-338. Epub 2017 Dec 16. PMID: 29248894

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Pubmed Data : Nutr Neurosci. 2019 Nov 18:1-12. Epub 2019 Nov 18. PMID: 31736428

Article Published Date : Nov 17, 2019

Study Type : Human Study

Additional Links

Substances : Bacopa, Coffee, Ginseng (American)

Diseases : Memory Disorders

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Acute exercise with meditation may enhance learning and long-term memory.Dec 31, 2018

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Pubmed Data : J Geriatr Phys Ther. 2017 Dec 28. Epub 2017 Dec 28. PMID: 29286983

Article Published Date : Dec 27, 2017

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease, Dementia

Therapeutic Actions : Exercise: Aerobic

Pharmacological Actions : Neuroprotective Agents

[+]

Aerobic fitness may have a positive influence on protection of brain even in aMCI CSF biomarker, a high-risk population to convert to AD.May 31, 2016

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Pubmed Data : Age (Dordr). 2016 Jun ;38(3):51. Epub 2016 Apr 23. PMID: 27106271

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Pubmed Data : J Diet Suppl. 2017 Nov 2 ;14(6):599-612. Epub 2017 Feb 21. PMID: 28471731

Article Published Date : Nov 01, 2017

Study Type : Human Study

Additional Links

Substances : Ashwagandha

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

[+]

Assessment of cognitive impairment and its correlation with vitamin D levels patients on maintenance hemodialysis.Feb 29, 2020

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Pubmed Data : J Ayurveda Integr Med. 2020 Dec 18. Epub 2020 Dec 18. PMID: 33349568

Article Published Date : Dec 17, 2020

Study Type : Human Study

Additional Links

Substances : Ayurvedic Formulations

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

Therapeutic Actions : Yoga

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Ayurveda

[+]

Both hydroponically cultivated red and wild growing white ginseng have similar beneficial effects on the cognitive functions of elderly subjects.Feb 24, 2021

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Pubmed Data : Br J Clin Pharmacol. 2020 Jun 1. Epub 2020 Jun 1. PMID: 32478863

Article Published Date : May 31, 2020

Study Type : Human Study

Additional Links

Substances : Cannabidiol

Diseases : Child Behavior Disorders, Learning disorders

Pharmacological Actions : Neuroprotective Agents

[+]

CBD enriched hemp oil could be beneficial in girls with adverse drug effects following human papillomavirus (HPV) vaccine.Jan 31, 2017

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Pubmed Data : Isr Med Assoc J. 2017 Feb ;19(2):79-84. PMID: 28457055

Article Published Date : Jan 31, 2017

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Pubmed Data : Int Rev Psychiatry. 2016 Jun ;28(3):288-98. Epub 2016 Jun 7. PMID: 27266893

Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement.Mar 11, 2019

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Pubmed Data : J Ethnopharmacol. 2019 Mar 12. Epub 2019 Mar 12. PMID: 30877066

Article Published Date : Mar 11, 2019

Study Type : Human Study

Additional Links

Substances : Goji

Diseases : Retinitis Pigmentosa

Pharmacological Actions : Neuroprotective Agents

[+]

Dewaxed brown rice has the potential to be a useful staple food that maintains brain homeostasis among elderly individuals.Dec 31, 2018

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Pubmed Data : J Neurol Neurosurg Psychiatry. 2004 Aug ;75(8):1093-9. PMID: 15258207

Pubmed Data : Int J Adolesc Med Health. 2020 Jun 6. Epub 2020 Jun 6. PMID: 32549168

Article Published Date : Jun 05, 2020

Study Type : Human Study

Additional Links

Therapeutic Actions : Therapeutic Breathing, Yoga, Yogic Breathing

Pharmacological Actions : Neuroprotective Agents

[+]

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Pubmed Data : Endocr J. 2020 Oct 17. Epub 2020 Oct 17. PMID: 33071273

[+]

Fortified yogurts with vitamin D twice a day maintained global cognitive performance and vitamin D status in older females.Nov 25, 2019

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Pubmed Data : Nutrients. 2019 Nov 26 ;11(12). Epub 2019 Nov 26. PMID: 31779179

Article Published Date : Nov 25, 2019

Study Type : Human Study

Additional Links

Substances : Vitamin D, Yoghurt

Diseases : Aging: Brain , Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Reduction

[+]

Freeze dried blueberry powder administration can enhance executive function during demanding elements of a task.Nov 14, 2017

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Pubmed Data : Food Funct. 2017 Nov 15 ;8(11):4129-4138. PMID: 29026903

Article Published Date : Nov 14, 2017

Study Type : Human Study

Additional Links

Substances : Blueberry

Diseases : Childhood Cognitive Disorders

Pharmacological Actions : Neuroprotective Agents

[+]

G. biloba seemed to slow down the cognitive deterioration in patients with vascular cognitive impairment.Dec 31, 2016

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Pubmed Data : Nutr Neurosci. 2020 Jan 16:1-10. Epub 2020 Jan 16. PMID: 31942838

Article Published Date : Jan 15, 2020

Study Type : Human Study

Additional Links

Substances : Grape Seed Extract

Diseases : Cognitive Decline/Dysfunction

Pharmacological Actions : Neuroprotective Agents

[+]

Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation.Jun 13, 2019

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Pubmed Data : Eur J Nutr. 2020 May 20. Epub 2020 May 20. PMID: 32435993

Article Published Date : May 19, 2020

Study Type : Human Study

Additional Links

Substances : Cryptoxanthin

Diseases : Childhood Cognitive Disorders

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Risk Reduction

[+]

Higher Mediterranean-style diet adherence was estimated to provide 1.5 to 3.5 years of protection against Alzheimer disease.May 14, 2018

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Pubmed Data : Neurology. 2018 May 15 ;90(20):e1789-e1798. Epub 2018 Apr 13. PMID: 29653991

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Pubmed Data : J Nutr Health Aging. 2019 ;23(8):725-731. PMID: 31560030

Article Published Date : Dec 31, 2018

Study Type : Human Study

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Substances : Vitamin D

Diseases : Dementia, Memory Disorders, Vitamin D Deficiency

Pharmacological Actions : Neuroprotective Agents

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Higher vitamin D status was associated with reduced problems memorizing new information in older community-dwellers. Dec 31, 2017

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Pubmed Data : Curr Alzheimer Res. 2018 ;15(7):664-670. PMID: 29422004

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Pubmed Data : Brain Cogn. 2017 04 ;113:23-31. Epub 2017 Jan 11. PMID: 28088064

Article Published Date : Dec 31, 2016

Study Type : Human Study

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Diseases : Parkinson's Disease

Therapeutic Actions : Exercise: Cycling

Pharmacological Actions : Neuroprotective Agents

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Improvement of cognitive functions by oral intake of Hericium erinaceus Dec 31, 2018

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Pubmed Data : J Gerontol A Biol Sci Med Sci. 2015 Aug 18. Epub 2015 Aug 18. PMID: 26286605

Multi-strain probiotic supplementation seems to exert a positive effect on neuroinflammation and neurocognitive impairment in HIV-1 infected subjects.Nov 20, 2017

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Pubmed Data : Nutrients. 2017 Nov 21 ;9(11). Epub 2017 Nov 21. PMID: 29160817

Article Published Date : Nov 20, 2017

Study Type : Human Study

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Substances : Probiotics

Diseases : Brain Inflammation , Cognitive Decline/Dysfunction, HIV Infections

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents

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N-acetyl-cysteine supplementation improves functional connectivity within the cingulate cortex in early psychosis.Jul 31, 2019

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Pubmed Data : Biomedicines. 2020 Sep 30 ;8(10). Epub 2020 Sep 30. PMID: 33007928

Article Published Date : Sep 29, 2020

Study Type : Human Study

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Substances : NAC (N-acetyl-L-cysteine)

Diseases : HIV Infections

Pharmacological Actions : Cytoprotective, Neuroprotective Agents

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Omega-3 FA intake combined with aerobic exercise and cognitive stimulation prevents atrophy in AD-related brain regions in MCI patients.Apr 30, 2016

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Pubmed Data : Neuroimage. 2016 May 1 ;131:226-38. Epub 2015 Oct 1. PMID: 26433119

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Pubmed Data : Nutr Neurosci. 2018 Feb 13:1-6. Epub 2018 Feb 13. PMID: 29433376

Article Published Date : Feb 12, 2018

Study Type : Human Study

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Substances : Pomegranate

Diseases : Stroke: Attenuation/Recovery

Pharmacological Actions : Neuroprotective Agents

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Postoperative administration of alpha-lipoic acid for 40 days after median nerve decompression may result in a lower incidence of pillar pain.Mar 31, 2017

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Pubmed Data : J Hand Surg Am. 2017 Apr ;42(4):236-242. Epub 2017 Feb 28. PMID: 28249792

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Pubmed Data : Neuroimage. 2020 May 23:116980. Epub 2020 May 23. PMID: 32454209

Article Published Date : May 22, 2020

Study Type : Human Study

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Substances : Psilocybin

Diseases : Psychiatric Disorders

Pharmacological Actions : Neuroprotective Agents

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Puerarin combined with conventional therapy on ischemic stroke had beneficial effects.Sep 30, 2017

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Pubmed Data : Exp Ther Med. 2017 Oct ;14(4):2943-2946. Epub 2017 Aug 11. PMID: 29042907

Article Published Date : Sep 30, 2017

Study Type : Human Study

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Substances : Puerarin

Diseases : Stroke: Ischemic

Pharmacological Actions : Neuroprotective Agents

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Acupuncture can be an effective treatment for patients unconscious following traumatic brain injury.Feb 20, 2020

Acupuncture for improving cognitive impairment after stroke.Dec 31, 2019

Acupuncture may be effective in improving cognitive function in vascular dementia animal models.Nov 12, 2018

Administration of vitamin C and vitamin E in animal models of spinal cord injury significantly improves the recovery of motor function.Dec 03, 2019

Available findings demonstrated the preclinical evidence that Ginsenoside-Rb1 has a potential neuroprotective effects.Dec 31, 2019

Baicalein exerts potential neuroprotective effects through multiple signaling pathways in animal models of Parkinson's disease.Dec 31, 2019

Cannabinoids significantly reduced infarct volume and improve functional outcome in experimental stroke models.Feb 28, 2015

Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis.Dec 31, 2017

Effect of ginsenoside-Rg1 on experimental Parkinson's disease.May 31, 2021

Efficacy of ethyl-EPA as a treatment for Huntington disease.Mar 19, 2019

Evidence supports the notion that N-acetylcysteine may be a useful adjunct to standard treatment for the improvement of schizophrenia symptoms.Dec 10, 2019

Ginkgo biloba extract appears to improve neurological function and dependence compared with conventional therapy for ischemic stroke.Dec 31, 2019

Ginkgo biloba is potentially beneficial for the improvement of cognitive function in patients with mild cognitive impairment or Alzheimer's disease.Dec 31, 2015

Huperzine A appears to have beneficial effects on improvement of cognitive function.Dec 31, 2012

Huperzine A is a well-tolerated drug that could significantly improve cognitive performance in patients with Alzheimer's disease and vascular dementia.Dec 31, 2013

Hyperbaric oxygen therapy had a neuro-protective effect and improved survival in animal models of MCAO.Dec 31, 2015

Meta-analysis of controlled trials testing horticultural therapy for the improvement of cognitive function.Sep 02, 2020

Meta-analytic findings suggested overall benefits of EGb 761 for stabilizing or slowing decline in cognition of subjects with cognitive impairment and dementia.Dec 31, 2014

Music could be a powerful treatment strategy in dementia.Dec 31, 2019

People with various levels of cognitive impairment can benefit from supervised multi-modal exercise.Dec 26, 2017

Perioperative melatonin reduced the incidence of delirium in older adults in the included studies. Oct 15, 2019

Qigong is a beneficial alternative therapy contributing to increasing motor function, walking ability, and balance for patients with Parkinson's disease.Nov 30, 2020

Resveratrol has a neuroprotective effect in a rat model of aging. Nov 30, 2008

Scalp acupuncture therapy may exhibit effects in the recovery of motor and nervous functions in patients with acute to chronic stroke.Jul 31, 2018

Taking a 240-mg daily dose of Ginkgo biloba extract is effective and safe in the treatment of dementia.Dec 31, 2014

Tetramethylpyrazine may serve as a promising new clinical candidate for the treatment of ischemic stroke.Jan 13, 2016

Therapeutic effects of meditation, yoga, and mindfulness-based interventions for chronic symptoms of mild traumatic brain injury.Nov 01, 2020

There is evidence that melatonin treatment after traumatic brain injury significantly improves both behavioural outcomes and pathological outcomes.Jun 13, 2018

These findings further guide the therapeutic strategy for clinical cerebral ischemic stroke.Dec 31, 2019

These findings indicate a potential therapeutic role of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucosidein Alzheimer's disease therapy.Aug 25, 2016

These results suggested that exercise programs might play an important role in cognition and activities of daily living in patients with dementia.Dec 31, 2018

This meta-analyses confirmed electroacupuncture is effective and safe for post stroke cognitive impairment.Oct 11, 2017

This meta-analysis suggests that physical activity interventions positively influence cognitive function in patients with dementia.Dec 31, 2015

This review suggests that adjunctive huperzine A is an effective choice for improving cognitive function in patients with schizophrenia spectrum disorders.Dec 31, 2015

This study suggests that meditation and mind-body exercises are effective to improve cognition of older adults aged 60 years or above.Feb 22, 2019

This supports the available scientific evidence on the beneficial role of naringin in the management of various neurological ailments.Sep 30, 2017

4 weeks of frankincense consumption facilitates the acquisition and retention of motor memory in older men with moderate mental status.Jan 07, 2019

A blueberry powder could can facilitate better episodic memory performance and improve cardiovascular function over 6 months.May 22, 2018

A flavonoid-rich blueberry product can provide acute cognitive benefits in children.Oct 15, 2018

A greater intake of choline and lutein and zeaxanthin was associated with faster performance on a cognitive flexibility task in overweight people.Jan 14, 2021

A high intake of nuts may protect older adults from cognitive decline.Nov 21, 2019

A ketogenic diet has anticonvulsant and neuroprotective effects. Jan 01, 2010

A Mediterranean diet supplemented with olive oil or nuts is associated with improved cognitive function in older populations. Jun 30, 2015

A moderate intake of EPA and DHA may postpone cognitive decline in elderly men. Apr 01, 2007

A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae.Feb 28, 2019

A polyphenol pattern provided by a diet containing specific plant products was associated with lower dementia risk.May 28, 2018

A polyphenol-rich extract from grape and blueberry improves age-related episodic memory decline in individuals with the highest cognitive impairments.Jul 18, 2018

A single bout of aerobic exercise improves motor skill consolidation in Parkinson's disease.Dec 31, 2017

A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis.Dec 31, 2017

A supplement containing huperzine A and curcumin in dementia patients and individuals with mild cognitive impairment had beneficial effects.Dec 31, 2017

Acetyl-l-carnitine has a neuroprotective effect against chemotherapy-induced allodynia. May 01, 2005

Acupuncture at Tiaoshen Yizhi acupoints can be used to improve cognitive function in patients with mild cognitive impairment.Jan 31, 2017

Acute effects of a polyphenol-rich leaf extract of Mangifera indica on cognitive function in healthy adults.Jul 22, 2020

Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex.Nov 17, 2019

Acute exercise with meditation may enhance learning and long-term memory.Dec 31, 2018

Adherence to Mediterranean diet and subsequent cognitive decline in men with cardiovascular disease.Jan 21, 2020

Aerobic exercise in early Alzheimer’s disease is associated with benefits in functional ability.Dec 31, 2016

Aerobic exercise sustains performance of instrumental activities of daily living in early-stage Alzheimer disease.Dec 27, 2017

Aerobic fitness may have a positive influence on protection of brain even in aMCI CSF biomarker, a high-risk population to convert to AD.May 31, 2016

Almond consumption leads to an improvement in cognitive function in overweight and obese patients. Jan 31, 2017

Alpha lipoic acid is an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Oct 01, 2008

Alpha lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.Dec 01, 2008

Alpha lipoic appears to be an effective neuroprotective agent in Alzheimer's disease. Jan 01, 2007

An anthocyanin rich blueberry concentrate improved brain perfusion and activation in brain areas associated with cognitive function.Feb 28, 2017

Aronia melanocarpa extract showed beneficial effects on cognitive performance and blood pressure in individuals at risk of cognitive decline.Aug 16, 2020

Art therapy is associated with sustained improvement in cognitive function in the elderly with mild neurocognitive disorder.Nov 08, 2018

Ascorbate status was positively associated with cognitive function in Parkinson's disease.Sep 22, 2020

Ashwagandha may be effective in enhancing both immediate and general memory in people with mild cognitive impairment.Nov 01, 2017

Assessment of cognitive impairment and its correlation with vitamin D levels patients on maintenance hemodialysis.Feb 29, 2020

B vitamins appear to slow cognitive and clinical decline in people with mild cognitive impairment, in particular in those with elevated homocysteine.Jul 21, 2011

Bacopa enhances cognitive performance in the aging.Jul 01, 2008

Bergamot polyphenolic fraction administration may be proposed as a potential supplementation strategy to improve cognitive outcome in schizophrenia.Jul 31, 2017

Neuroprotective Agents

View the Evidence:
4390 Abstracts with Neuroprotective Agents Research