NF-kappaB Inhibitor

Name	AC	CK
Curcumin	247	356
Resveratrol	52	89
Ginsenosides	34	56
Flavonoids	22	46
Puerarin	20	46
Polyphenols	19	44
Thymoquinone	28	44
Genistein	16	38
Parthenolide	24	36
Astaxanthin	15	34
Ginger	14	32
Apigenin	12	31
Paeoniflorin	18	28
Pomegranate	10	27
Berberine	16	23
Melatonin	15	23
Tanshinone IIA	16	23
Fisetin	12	22
Sulforaphane	19	22
Vitamin C	12	22
Caffeic acid phenethyl ester	10	21
Green Tea	8	21
Quercetin	12	20
Asiatic Acid	11	19
Garlic	8	19
Olive Oil	5	19
Stilbenes	12	19
Naringenin	9	18
EGCG (Epigallocatechin gallate)	12	17
Lychee	8	17
Vitamin D	11	17
Anthocyanins	9	16
Nobiletin	8	16
Phloretin	8	16
Pterostilbene	9	16
Xanthohumol	11	16
Blueberry	7	15
Cannabidiol	9	15
Luteolin	8	15
Deguelin	8	14
Hesperidin	8	14
Isoflavones	3	14
Bilberry	3	13
Black Tea	4	13
Chrysin	8	13
Fucoidan	9	13
Pycnogenol (Pine Bark)	3	13
Rosmarinic acid	5	13
Bee Venom	6	12
Black Raspberry	2	12
Lactobacillus fermentum	2	12
Piceatannol	9	12
Purslane	3	12
Astragaloside	6	11
Diosgenin	6	11
Ellagic Acid	7	11
Ginkgo biloba	6	11
Isoliquiritigenin	6	11
Nigella sativa (aka Black Seed)	2	11
Strawberry	2	11
Carnosic Acid	6	10
Carnosine	1	10
Chaga Mushroom (Inonotus obliquus)	7	10
Dandelion	8	10
Fruit: All	1	10
Geraniol	5	10
Gingerol	6	10
Honokiol	6	10
Lactobacillus Acidophilus	1	10
Lactobacillus delbrueckii Subsp	1	10
Lotus	8	10
Mangiferin	7	10
Vitamin E: alpha tocopherol	4	10
Yoghurt	1	10
Zyflamend	1	10
6-Shogaol	7	9
Ashwagandha	5	9
Reishi Mushroom	5	9
Rose	6	9
Shikonin	7	9
Sweet Potato: Purple	5	9
Acai	3	8
Alpha-Lipoic Acid	4	8
Garlic: Aged	3	8
Grape Seed Extract	5	8
Lactobacillus rhamnosus GG	3	8
Nexrutine (Phellodendrom)	4	8
Oleuropein	5	8
Palmitoylethanolamide	4	8
Piperlongumine	5	8
Prunella vulgaris	4	8
Rooibos	4	8
Selenium	5	8
Astragalus	2	7
Bee Propolis	4	7
Carnosol	4	7
Chinese Skullcap	4	7
Goji	4	7
Helenalin	6	7
Hydroxytyrosol	4	7
Kaempferol	4	7
Ligustrazine	4	7
Lycopene	4	7
NAC (N-acetyl-L-cysteine)	5	7
Piperine	5	7
Rosemaric Acid	4	7
Tangeretin	5	7
Turmeric	5	7
Verbascoside	5	7
Wogonin	5	7
Arginine	3	6
Arnica	6	6
Bamboo	4	6
Capsaicin	5	6
Cinnamaldehyde	4	6
Citrus naringin	3	6
Diosmin	4	6
EPA (Eicosapentaenoic Acid)	3	6
Echinacea	2	6
Emodin	4	6
Gastrodin	4	6
Ginseng (Korean)	4	6
Honey	4	6
Indole-3-Carbinol	4	6
Magnolol	4	6
Myricetin	5	6
Punicalagin	4	6
Silibinin	4	6
Triptolide	4	6
Ursolic Acid	5	6
Vitamin E	4	6
Allicin	3	5
Angelica	1	5
Apples	3	5
Arctigenin	4	5
Baicalein	4	5
Bromelain	5	5
Cardamonin	3	5
Chrysanthemum Indicum	4	5
Citral	1	5
Crocin	3	5
Cryptoxanthin	3	5
Diallyl sulfide	3	5
Ferulic acid	3	5
Feverfew	5	5
Flaxseed	3	5
Fucoxanthin	3	5
Glycyrrhizin	5	5
Lutein	3	5
Omega-3 Fatty Acids	3	5
Persimmon	4	5
Rutin	3	5
Tocotrienol: Delta	3	5
Vitamin K2	4	5
Wasabi	3	5
Arugula	2	4
Bifidobacterium Longum	2	4
Blackberry	2	4
Chokeberry	3	4
Cordyceps sinensis	2	4
Crocetin	2	4
DHA (Docosahexaenoic Acid)	2	4
Daidzein	2	4
Damnacanthal	3	4
Delphinidin	2	4
Fermented Foods and Beverages	2	4
Ginseng (Siberian)	2	4
Gotu Kola	2	4
Hydrogen Water	2	4
Lactobacillus plantarum	2	4
Loquat	3	4
Magnolia	3	4
Moringa oleifera	4	4
Oats	3	4
Perilla	2	4
Rosemary	3	4
Sea buckthorn	2	4
Sesamol	3	4
Spikenard	3	4
Tart Cherry	2	4
Theanine	2	4
Tomato	3	4
Tripterygium wilfordii	3	4
Walnut	2	4
White Tea	2	4
Zerumbone	2	4
Aloe Vera	2	3
Andrographolide	2	3
Artemisinin	3	3
Avocado	2	3
Bergamot orange	2	3
Beta Sitosterol	2	3
Bufalin	2	3
Caffeic Acid	2	3
Cannabis	2	3
Carotenoids	2	3
Catechin	3	3
Chlorophyllin	2	3
Coenzyme Q10	2	3
Corn Silk	2	3
Cyanidin	2	3
D-Limonene	2	3
Ginseng	2	3
Guava	2	3
Isothiocyanates	3	3
Licorice	2	3
Lion's Mane (Hericium Erinaceus)	2	3
Lupeol	3	3
Magnesium	2	3
Neem	2	3
Olive	2	3
Olive leaf extract	2	3
Palm Oil	2	3
Panax Notoginseng	2	3
Sesamin	2	3
Soy	2	3
Theaflavins	2	3
Toona sinensis	2	3
Vanillin	2	3
Vitamin E: Gamma-tocotrienol	3	3
Vitamin K	2	3
Vitexins	2	3
White Mulberry	2	3
2-Methoxyestradiol	1	2
4-Shogaol	2	2
Amygdalin (laetrile)	2	2
Anemarrhena asphodeloides	1	2
Antrodia Camphorate	1	2
Apocynin	1	2
Apricot	1	2
Bai Zhu	1	2
Barley	1	2
Basil	1	2
Berbamine	2	2
Bisdemethoxycurcumin	2	2
Bitter Melon	1	2
Bitter Orange	2	2
Broccoli Sprouts	2	2
Burdock	2	2
Camel Milk	1	2
Carvacrol	1	2
Cat's Claw	2	2
Chlorogenic Acid	1	2
Cinnamon	1	2
Citrus Peel	1	2
Coffee	1	2
Coptis chinensis	1	2
Coriandrum sativum	1	2
Corn: Purple	1	2
Cranberry	1	2
Cucurbitacin B	1	2
Curcumin: Degradiation byproducts	2	2
Demethoxycurcumin	2	2
Dopa bean	1	2
Epimedium	1	2
Fennel	1	2
Fig	1	2
Fish Oil	1	2
Flavan-3-ols	1	2
Flaxseed Oil	1	2
Folic Acid	1	2
Frankincense	2	2
Garcinia Mangostana	1	2
Gardenia	1	2
Glucosamine	1	2
Gold (nanoparticles)	1	2
Grape	1	2
Grapefruit	1	2
Guduchi	1	2
Hemp Seed	2	2
Hibiscus sabdariffa	1	2
Histidine	1	2
Holy Basil	1	2
Huperzine	2	2
Kaempferia parviflora	1	2
Kimchi	2	2
Kiwifruit	1	2
Lemongrass	1	2
Lignans	2	2
Litchi	1	2
Lithospermum erythrorhizon	2	2
Long Pepper	1	2
Maca	1	2
Manuka Honey	1	2
Medium Chain Triglycerides	1	2
Milk Thistle	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Mung Bean	1	2
Myrrh	1	2
Niacin	1	2
Noni	1	2
Patchouli	1	2
Peach	1	2
Pelargonium sidoides	1	2
Phellinus Linteus	1	2
Phenethyl isothiocyanate	2	2
Phyllanthus amarus	2	2
Pine Bark Extract	2	2
Plantago asiatica	1	2
Potato	1	2
Potato: Pigmented	1	2
Probiotics	1	2
Propolis: Brazillian	1	2
Psychedelics:All	2	2
Raspberry	1	2
Red Sage	1	2
Rhubarb	2	2
Rice	1	2
Royal Jelly	1	2
Rubia Cordifolia	1	2
Saccharomyces Boulardii	1	2
Saikosaponin	1	2
Saturated fatty acids	1	2
Seaweed	1	2
Shiitake Mushroom	1	2
Silymarin	1	2
Sinomenine	1	2
Soy: Fermented	1	2
Soybean: Black	1	2
Stigmasterol	1	2
Sweet Potato	1	2
Tannic Acid	1	2
Tetrahydrocurcumin	1	2
Thistle	2	2
Thymol	1	2
Tongkat Ali	1	2
Vitamin E: Gamma-Tocopherol	1	2
Vitamin E: delta-tocopherol	1	2
Vitex negundo	1	2
Watermelon	1	2
White Pepper	1	2
neohesperidin	1	2
Acacia catechu	1	1
Acorus calamus	1	1
Adlay	1	1
Aduki bean	1	1
Andrographis	1	1
Antrodia camphorata	1	1
Apple Pectin	1	1
Apple Polyphenols	1	1
Artichoke	1	1
Ayahuasca	1	1
Bael	1	1
Bay leaf	1	1
Benzyl isothiocyanate	1	1
Berries: All	1	1
Betulinic acid	1	1
Black Pepper	1	1
Boswellia	1	1
Broccoli	1	1
Cafestol	1	1
Caffeoylquinic Acids	1	1
Capparis spinosa (caper)	1	1
Catechols	1	1
Chickpea	1	1
Chicoric Acid	1	1
Chitosan	1	1
Chlorella (Algae)	1	1
Copper	1	1
Cordyceps Militaris	1	1
Cucurbitacin D	1	1
Cucurbitacin E	1	1
Cumin	1	1
Curcumin: Lipidated	1	1
Delta-tetrahydrocannabinol (THC)	1	1
Dibenzoylmethane (DBM)	1	1
Epicatechin	1	1
Eucalyptus	1	1
Feijoa	1	1
Flowers	1	1
Gallic Acid	1	1
Garcinia indica	1	1
Genipin	1	1
Ginseng (American)	1	1
Guggul	1	1
Gynostemma	1	1
Hibiscus rosa-sinensis	1	1
Hirudin (from Medicinal Leaches)	1	1
Hops	1	1
Houttuynia cordata	1	1
Huaier (Trametes robiniophila murr)	1	1
Hyaluronic Acid	1	1
Hyperforin	1	1
Jujube	1	1
Justicia gendarussa	1	1
Kahweol	1	1
Kava Kava	1	1
Krill	1	1
Lactobacillus paracasei	1	1
Lactobacillus reuteri	1	1
Lactobacillus rhamnosus	1	1
Lavender: Essential Oil	1	1
Lingonberry	1	1
Loquat Leaves	1	1
Lysine	1	1
Mangosteen	1	1
Marjoram	1	1
Matairesinol	1	1
Methylchlorogenic acid	1	1
Motherwort	1	1
Mushrooms: All	1	1
Nicotinamide	1	1
Nutmeg	1	1
Octacosanol	1	1
Pachymic acid	1	1
Papain	1	1
Papaya	1	1
Passion Flower	1	1
Phyllanthus niruri (Stonebreaker)	1	1
Phyllanthus urinaria	1	1
Pine Cone	1	1
Polyunsaturated Fatty Acids (PUFAs)	1	1
Poria cocos	1	1
Potassium	1	1
Proanthocyanidins	1	1
Procyanidin B2	1	1
Psyllium	1	1
Raisins	1	1
Red Wine Extract	1	1
Rice: Black	1	1
Sesame Seeds	1	1
Sessile Joyweed	1	1
Sophora Flavescens	1	1
St. Johns Wort	1	1
Sumac	1	1
Syrian rue	1	1
Tansy	1	1
Taurine	1	1
Thyme	1	1
Toad	1	1
Tocotrienol: Gamma	1	1
Tomatidine	1	1
Tribulus	1	1
Turmerones	1	1
Tyrosol	1	1
Unsaponifiables	1	1
Vitamin K2: Menaquinone-7	1	1
Willow Bark	1	1
acetyl-11-keto-beta-boswellic acid	1	1
cottonseed oil (gossypol)	1	1

[+]

Aerobic training and purslane seed ere effective in the regulation of diabetic biomarkers associated with atherosclerosis in women with T2D.Dec 04, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 Dec 5 ;6:37819. Epub 2016 Dec 5. PMID: 27917862

Article Published Date : Dec 04, 2016

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Prev Res (Phila). 2012 Jan ;5(1):41-50. Epub 2011 Dec 1. PMID: 22135048

Article Published Date : Dec 31, 2011

Study Type : Human Study

Additional Links

Substances : Strawberry

Diseases : Esophageal Cancer

Pharmacological Actions : Antiproliferative , Chemopreventive, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor

Additional Keywords : Plant Extracts, Risk Reduction

[+]

French maritime pine bark extract (Pycnogenol) displays anti-inflammatory effects in vivo.Jan 01, 2006

Click here to read the entire abstract

Pubmed Data : J Inflamm (Lond). 2006;3:1. Epub 2006 Jan 27. PMID: 16441890

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Inflammation

Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

[+]

Fruit and vegetable juice concentrate may be beneficial for improving the metabolic profile in obese individuals. Feb 07, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2017 Feb 8 ;9(2). Epub 2017 Feb 8. PMID: 28208713

Click here to read the entire abstract

Pubmed Data : Mol Neurobiol. 2016 May ;53(4):2529-40. Epub 2015 Jun 17. PMID: 26081140

Article Published Date : Apr 30, 2016

Study Type : Human Study

Additional Links

Substances : Ginsenosides

Diseases : Stroke: Ischemic

Pharmacological Actions : Neuroprotective Agents, NF-kappaB Inhibitor

[+]

Green tea induced changes in NFκB and systemic oxidation, and uptake of GT polyphenols in prostate tissue they may have a role in prostate cancer prevention and treatment.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : Prostate. 2015 Apr 1 ;75(5):550-9. Epub 2014 Dec 24. PMID: 25545744

Pubmed Data : Metab Syndr Relat Disord. 2018 Jun 29. Epub 2018 Jun 29. PMID: 29957104

Article Published Date : Jun 28, 2018

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Puerarin acts as an anti-inflammatory agent by blocking NF-kappaB signalling.Jul 31, 2010

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Hepatol Res. 2018 Jun 1. Epub 2018 Jun 1. PMID: 29855113

Article Published Date : May 31, 2018

Study Type : Human Study

Additional Links

Substances : Resveratrol

Diseases : Cholestasis, Pregnancy Complications

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia.Apr 18, 2019

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2016 Feb 17 ;179:412-9. Epub 2015 Dec 21. PMID: 26719285

Article Published Date : Feb 16, 2016

Study Type : Human In Vitro

Additional Links

Substances : Angelica, Astragalus

Diseases : Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Renoprotective

[+]

Anthocyanins from wild blueberry reduce the activation of NF-kB and mitigate IL-1B activity human intestinal cells.Aug 20, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Agric Food Chem. 2014 Aug 20 ;62(33):8346-51. Epub 2014 Aug 8. PMID: 25075866

Article Published Date : Aug 20, 2014

Study Type : Human In Vitro

Additional Links

Substances : Anthocyanins

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

[+]

Antioxidant mixtures could prevent the harmful effects of ozone induced oxidative stress in human keratinocytes.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Biochem Pharmacol. 2017 Mar 15 ;128:26-33. Epub 2016 Dec 23. PMID: 28017776

Article Published Date : Mar 14, 2017

Study Type : Human In Vitro

Additional Links

Substances : Nobiletin

Diseases : Cholesterol: Oxidation, Oxidative Stress

Pharmacological Actions : Antithrombotic, Cardiovascular Agents, NF-kappaB Inhibitor

[+]

These results indicate the potential for açai polyphenolics in the prevention of intestinal inflammation.Oct 06, 2015

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Pubmed Data : Food Funct. 2015 Oct 7 ;6(10):3249-56. PMID: 26243669

Article Published Date : Oct 06, 2015

Study Type : Human In Vitro

Additional Links

Substances : Acai

Diseases : Gastrointestinal Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response

[+]

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Eur J Pharmacol. 2020 Sep 5 ;882:173264. Epub 2020 Jun 13. PMID: 32544504

Article Published Date : Sep 04, 2020

Study Type : Animal Study

Additional Links

Substances : Vitexins

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor

[+]

"Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats."Dec 01, 2008

Click here to read the entire abstract

Pubmed Data : Clinics (Sao Paulo). 2008 Dec ;63(6):807-13. PMID: 19061005

Article Published Date : Dec 01, 2008

Study Type : Animal Study

Additional Links

Substances : Ginger

Diseases : Liver Cancer: Prevention

Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

"Tanshinone IIA prevents uric acid nephropathy in rats through NF-κB inhibition."May 31, 2012

Click here to read the entire abstract

Pubmed Data : Planta Med. 2012 Jun ;78(9):866-73. Epub 2012 May 15. PMID: 22588836

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Drug Des Devel Ther. 2016 ;10:2239-53. Epub 2016 Jul 11. PMID: 27468227

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors, Wnt/β-catenin signaling pathway modulation

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Gene Expression Regulation

[+]

6-gingerol alleviates inflammatory injury in DSS-induced ulcerative colitis.Jul 13, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Ann Palliat Med. 2020 Jul 14. Epub 2020 Jul 14. PMID: 32692218

Article Published Date : Jul 13, 2020

Study Type : Animal Study

Additional Links

Substances : Gingerol

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, NF-kappaB Inhibitor

[+]

Additional Keywords : Polysaccharides

[+]

A water-soluble extract from Actinidia arguta ameliorates psoriasis-like skin inflammation.Oct 01, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2018 Oct 2 ;10(10). Epub 2018 Oct 2. PMID: 30279326

Pubmed Data : Eur J Pharmacol. 2020 Mar 2:173052. Epub 2020 Mar 2. PMID: 32135124

Article Published Date : Mar 01, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Allicin

Diseases : Diabetic Complications

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation

[+]

Allicin provides protection against arsenic trioxide induced liver injury. Feb 28, 2017

Click here to read the entire abstract

Pubmed Data : Biol Trace Elem Res. 2017 Mar ;176(1):192-200. Epub 2016 Aug 25. PMID: 27561292

Article Published Date : Feb 28, 2017

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2016 Sep 18 ;8(9). Epub 2016 Sep 18. PMID: 27649243

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2016 Jan 20. Epub 2016 Jan 20. PMID: 26801071

Article Published Date : Jan 19, 2016

Study Type : Animal Study

Additional Links

Substances : Apigenin, Naringenin

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypoglycemic Agents, Hypolipidemic, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation

[+]

Apigenin enhances the anti-tumor effect of gemcitabine. Jan 18, 2008

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2008 Jan 18;259(1):39-49. Epub 2007 Oct 29. PMID: 17967505

Article Published Date : Jan 18, 2008

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Drug: Gemcitabine, Drug-Plant-Vitamin Synergies

[+]

Apigenin may be an alternative therapeutic option for prevention of sepsis-induced organ damage. May 31, 2016

Click here to read the entire abstract

Pubmed Data : Immunopharmacol Immunotoxicol. 2016 Jun ;38(3):228-237. PMID: 27144896

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-10 upregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2015 ;67(1):177-90. Epub 2014 Nov 20. PMID: 25412264

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Apples

Diseases : Colitis, Colon Cancer, Colon Cancer: Prevention

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

[+]

Apple total triterpenoid content induced apoptosis in MDA-MB-231 cells.Sep 18, 2012

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Pubmed Data : J Agric Food Chem. 2012 Sep 19 ;60(37):9430-6. Epub 2012 Sep 6. PMID: 22924395

Click here to read the entire abstract

Pubmed Data : Biotech Histochem. 2020 Feb ;95(2):121-128. Epub 2019 Sep 6. PMID: 32064961

Article Published Date : Jan 31, 2020

Study Type : Animal Study

Additional Links

Substances : Artemisinin

Diseases : Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Chemoprotective Agents, Hepatoprotective, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Artesunate exerts protective effects against ulcerative colitis .Jul 31, 2019

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Mol Cell Biochem. 2016 Dec 21. Epub 2016 Dec 21. PMID: 28004351

Article Published Date : Dec 20, 2016

Study Type : Animal Study

Additional Links

Substances : Ashwagandha

Diseases : Brain Inflammation , Insomnia, Sleep Disorders

Pharmacological Actions : Anti-Anxiety Agents, Anti-Apoptotic, Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

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Ashwagandha treatment reversed the cytoplasmic mislocalization of hTDP-43 in spinal motor neurons and in brain.Dec 06, 2016

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Pubmed Data : Biomed Pharmacother. 2017 Sep 11 ;95:974-982. Epub 2017 Sep 11. PMID: 28915539

Article Published Date : Sep 10, 2017

Study Type : Animal Study

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Substances : Astaxanthin

Diseases : Lung Injury: Acute

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor

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Astaxanthin and lutein have neuroprotective effects and reduce ocular oxidative stress, and inflammation in the STZ diabetic rat model.Dec 31, 2015

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Pubmed Data : Toxins (Basel). 2019 Sep 17 ;11(9). Epub 2019 Sep 17. PMID: 31533259

Article Published Date : Sep 16, 2019

Study Type : Animal Study

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Substances : Astaxanthin

Diseases : Lung Damage

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, NF-kappaB Inhibitor, Nrf2 activation

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Astaxanthin significantly suppressed the occurrence of esophageal cancer.Dec 31, 2018

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Pubmed Data : J HIV AIDS. 2016 May ;2(3). Epub 2016 May 11. PMID: 27398410

Article Published Date : Apr 30, 2016

Study Type : Animal Study

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Substances : Bamboo

Diseases : Brain Inflammation , HIV Infections

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

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Bamboo leaf flavonoids can effectively improve depression in diabetic rats.Apr 22, 2019

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Pubmed Data : Zhonghua Yi Xue Za Zhi. 2019 Apr 23 ;99(16):1251-1255. PMID: 31060166

Article Published Date : Apr 22, 2019

Study Type : Animal Study

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Substances : Bamboo, Flavonoids

Diseases : Depression, Diabetic Complications

Pharmacological Actions : Antidepressive Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Basil essential oil exhibits protective effects against acetic acid-induced colitis. Nov 29, 2015

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Pubmed Data : J Evid Based Complementary Altern Med. 2015 Nov 30. Epub 2015 Nov 30. PMID: 26620574

Article Published Date : Nov 29, 2015

Study Type : Animal Study

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Substances : Basil

Diseases : Colitis, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, NF-kappaB Inhibitor

Additional Keywords : Essential Oils

[+]

Bee venom could be applicable as an anti-colon cancer agent.Oct 29, 2015

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Pubmed Data : Behav Neurol. 2018 ;2018:1960106. Epub 2018 Jun 3. PMID: 29971136

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Biochanin A

Diseases : Brain Inflammation , Subarachnoid hemorrhage

Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents, NF-kappaB Inhibitor

[+]

Blackberry and blueberry anthocyanins ameliorated diet-induced obesity by alleviating oxidative stress, inflammation and accelerating energy expenditure.Dec 31, 2017

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View the Evidence: 2001 Abstracts with NF-kappaB Inhibitor Research

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Aerobic training and purslane seed ere effective in the regulation of diabetic biomarkers associated with atherosclerosis in women with T2D.Dec 04, 2016

Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes.Oct 01, 2010

Bilberry has anti-inflammatory properties.Sep 01, 2010

Cashew may have anti-inflammatory activity in rheumatoid arthritis patients.Dec 06, 2006

Consumption of Nigella sativa can reduce the inflammatory biomarkers in patients with NAFLD.May 31, 2019

Curcumin selectively induces programmed cell death in cutaneous T-cell lymphoma cell lines and in peripheral blood mononuclear cells (PBMCs).Aug 01, 2010

Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.Dec 31, 2011

French maritime pine bark extract (Pycnogenol) displays anti-inflammatory effects in vivo.Jan 01, 2006

Fruit and vegetable juice concentrate may be beneficial for improving the metabolic profile in obese individuals. Feb 07, 2017

Genistein and puerarin could inhibit the pathway of NF-kappaB and TNF-alpha in asthma patients.Jan 31, 2010

Ginger can improve rheumatoid arthritis by decreasing disease manifestations in patients.May 24, 2019

Ginsenoside Rd is efficacious against acute ischemic stroke.Apr 30, 2016

Green tea induced changes in NFκB and systemic oxidation, and uptake of GT polyphenols in prostate tissue they may have a role in prostate cancer prevention and treatment.Mar 31, 2015

Hesperidin supplementation accompanied with lifestyle modification is superior to lifestyle modification alone in management of NAFLD.Jun 30, 2019

Hyperbaric oxygen therapy regulated the inflammatory reaction in secondary spinal cord injury.Oct 31, 2018

L-carnosine protects against oxaliplatin-induced peripheral neuropathy in colorectal cancer patients.Feb 14, 2019

Lactobacillus acidophilus modulates inflammatory activity by regulating the TLR4 and NF-κB expression in porcine peripheral blood mononuclear cells.Feb 27, 2016

Low-fat yogurt for 9 weeks reduced biomarkers of chronic inflammation and endotoxin exposure in premenopausal women.Nov 30, 2017

Lyophilized black raspberries significantly decreased urinary lipid peroxidation levels and significantly increased GST-pi, a marker of detoxification.Jul 06, 2016

Olive oil consumption has an ameliorative effect in non-alcoholic fatty liver disease.Apr 21, 2009

Oral supplementation with probiotics could be helpful in maintaining remission and preventing relapse of ulcerative colitis.Sep 06, 2010

Pomegranate juice increases sirtuin1 protein in peripheral blood mononuclear cell from patients with type 2 diabetes.Jun 28, 2018

Puerarin acts as an anti-inflammatory agent by blocking NF-kappaB signalling.Jul 31, 2010

Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats.Jan 01, 2017

Resveratrol and genistein may be potential drugs candidates for use in the treatment of COPD.Mar 27, 2016

Resveratrol could be a potential therapeutic target for intrahepatic cholestasis of pregnancy.May 31, 2018

Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia.Apr 18, 2019

Sudharshan kriya pranayama can significantly decrease periodontal inflammation and improve periodontal status.Feb 05, 2020

The inhibitory effects of curcumin support its utility as a prophylactic and therapeutic agent for inflammatory bone diseases such as periodontitis.Jul 31, 2015

Thoughts modulate the expression of inflammatory genes and may improve the coronary blood flow in patients after a myocardial infarction.Dec 31, 2017

Three months treatment with curcumin in chronic kidney disease patients undergoing hemodialysis resulted in decreased markers of inflammation.Mar 12, 2020

Zyflamend (a multi-herbal formula) has significant therapeutic activity in treating high-grade prostatic intraepithelial neoplasia. Mar 01, 2009

A Polyphenol-rich pomegranate fruit extract suppresses NF-κB and IL-6 expression.Mar 08, 2017

Alpha-bisobolol inhibits lipopolysaccharide-induced inflammation.Oct 01, 2011

Ammi visnaga, parsley, barley, and camel's grass all display renoprotective effects.Jun 25, 2019

Angelica and Astragalus could protect against oxidative stress-induced apoptosis in kidney epithelium.Feb 16, 2016

Anthocyanins from wild blueberry reduce the activation of NF-kB and mitigate IL-1B activity human intestinal cells.Aug 20, 2014

Antioxidant mixtures could prevent the harmful effects of ozone induced oxidative stress in human keratinocytes.Dec 31, 2014

Apigenin could be a useful compound to prevent proliferation and migration of cancer cells as well as cancer stem cells.Aug 24, 2016

Apigenin highly upregulated the expression of cytokine genes and induced apoptosis in human pancreatic cancer cells.Nov 30, 2013

Caffeic acid phenethyl ester could be effective for treating of periodontal diseases.Nov 06, 2016

Citral inhibits LPS-induced inflammatory response via activating PPAR-γ which attenuates NF-κB activation.Dec 10, 2015

Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.Jun 25, 2017

Curcumin might prevent early bacterial or virus infection into the lumen of the intestine or reduce the degree of the infection by inhibiting the inflammatory response.Mar 31, 2015

Diallyl disulfide could be a promising anticancer agent for anti-metastatic treatment of esophageal-gastric junction adenocarcinoma in the future.Jan 31, 2018

Elderflower inhibits all pro-inflammatory activities of major periodontal pathogens.Feb 01, 2006

Epigenetic upregulation of metallothionein 2A by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel.Jan 21, 2016

Lactobacillus rhamnosus GG conditioned medium prevents E. coli meningitis by inhibiting nuclear factor-κB pathway.Jan 19, 2017

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Nexrutine as an agent to potentiate the therapeutic response of docetaxel by suppressing activation of c-FLIP and its upstream regulators.May 08, 2017

Oleocanthal inhibits catabolic and inflammatory mediators in LPS-activated human primary osteoarthritis chondrocytes.Dec 31, 2017

Oligonol suppresses inflammatory cytokine production from human monocytes.May 31, 2016

Olive oil compounds inhibit the effect of the chronic inflammatory microenvironment on glioblastoma progression.Aug 31, 2015

Parthenolide may be a promising component for bone regeneration in periodontitis treatment.Aug 21, 2017

Prunella vulgaris attenuates diabetic renal injury.Mar 29, 2017

Puerarin possessed certain anticoagulation and may be a potential novel therapeutic drug for thrombosis in coronary artery disease.Dec 14, 2017

Rosmarinic acid may be a potential candidate for the treatment of psoriasis.Jun 14, 2016

T. cordifolia dry leaf extracts possess antioxidant and anti-inflammatory properties.Jul 31, 2019

These data suggest that nobiletin might be a potential antithrombotic agent of dietary origin.Mar 14, 2017

These results indicate the potential for açai polyphenolics in the prevention of intestinal inflammation.Oct 06, 2015

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

These results suggest that apamin has therapeutic effect on atopic dermatitis through improvement of inflammatory condition.Apr 17, 2017

These results suggest that HEABG may be effective in the prevention and treatment of endometriosis in humans.Jun 30, 2013

These results suggests the possible use of apigenin as a chronic rhinosinusitis therapeutic agent which can suppress tissue remodelling in nasal mucosa.Dec 31, 2017

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.Nov 01, 2018

Thymoquinone inhibited IL-1β-induced inflammatory mediator production by inhibition of NF-κB and MAPKs signaling pathways in osteoarthritis chondrocytes.Jul 08, 2015

Triterpene ganoderic acid inhibited production of TNF-α and other proinflammatory cytokines by PBMCs and inflamed CD colonic mucosa due to blockage of NF-κB activation.May 18, 2015

Vitamin D rescues impaired Mycobacterium tuberculosis-mediated tumor necrosis factor release in macrophages of HIV-seropositive individuals.Dec 31, 2012

Vitamin D supplement may be a potential strategy for the oral lichen planus management.Feb 22, 2017

Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-κB via activation of SIRT1 in mice.Jul 31, 2020

Cardioprotective effect of thymol against adrenaline-induced myocardial injury in rats.Jun 30, 2020

Emodin exerts a protective effect in CVB3-mediated encephalitis in HFMD by inhibiting the TLR3 pathway.Jul 05, 2020

NF-kappaB Inhibitor

View the Evidence:
2001 Abstracts with NF-kappaB Inhibitor Research