NF-kappaB Inhibitor

Name	AC	CK
Curcumin	293	437
Flavonoids	196	338
Ginsenosides	87	143
Resveratrol	70	121
Berberine	46	88
Polyphenols	39	82
Puerarin	35	80
Paeoniflorin	41	66
Thymoquinone	41	66
Astaxanthin	33	62
Ginkgo biloba	36	59
Tanshinone IIA	37	56
Parthenolide	33	50
Salvia miltiorrhiza	28	50
Genistein	23	49
Ginger	25	49
Apigenin	22	46
Paeonol	26	46
Anthocyanins	22	45
Vitamin D	21	45
Melatonin	27	43
Hesperidin	19	41
Quercetin	29	41
Sulforaphane	30	41
Astragaloside	24	39
Hydrogen Water	16	38
Luteolin	22	38
Vitamin C	23	38
Crocin	18	37
Leonurine	20	37
Reishi Mushroom	19	37
Mangiferin	23	36
EGCG (Epigallocatechin gallate)	25	35
Licorice	25	35
Naringenin	20	35
Lactoferrin	9	34
Andrographolide	21	33
Garlic	16	32
Piperine	11	32
Pomegranate	13	32
Pterostilbene	19	32
Sinomenine	18	32
Asiatic Acid	18	31
Green Tea	13	30
Lotus	20	30
Nobiletin	16	30
Fisetin	17	29
Caffeic acid phenethyl ester	15	28
Ellagic Acid	16	28
Emodin	17	28
Chrysin	17	27
Fucoidan	17	27
Cannabidiol	17	26
Punicalagin	17	26
Ursolic Acid	17	26
Blueberry	13	25
Diosgenin	13	25
Honokiol	11	25
Isoliquiritigenin	14	25
Peony	16	25
Piceatannol	16	25
Black Tea	10	24
Icariin	15	24
Turmeric	17	24
Echinacea	12	23
Phloretin	12	23
Silibinin	9	23
Alpha-Lipoic Acid	13	22
Dandelion	15	22
Lycopene	13	22
Andrographis	12	21
Bee Propolis	8	21
Citrus naringin	13	21
Formononetin	11	21
Isoflavones	8	21
Olive Oil	7	21
Patchouli	15	21
Poria cocos	12	21
Stilbenes	14	21
Apocynin	10	20
Ferulic acid	11	20
Kaempferol	13	20
Rose	14	20
Rosmarinic acid	10	20
Xanthohumol	14	20
Bee Venom	10	19
Elecampane	16	19
Lactobacillus plantarum	10	19
Chaga Mushroom (Inonotus obliquus)	12	18
Dogwood	11	18
Grape	7	18
Grape Seed Extract	10	18
Olive leaf extract	6	18
Piperlongumine	11	18
Diosmin	10	17
Fucoxanthin	10	17
Lactobacillus fermentum	5	17
Lychee	8	17
Safflower	11	17
Biochanin A	9	16
Ginseng	8	16
Ligustrazine	10	16
Magnolol	12	16
Myricetin	11	16
Seaweed: Brown	10	16
Wogonin	11	16
6-Shogaol	11	15
Betulinic acid	11	15
Chlorogenic Acid	10	15
Geraniol	8	15
Gingerol	9	15
Ginseng (Korean)	9	15
Lupeol	8	15
Moringa oleifera	11	15
Mulberry	10	15
Prunella vulgaris	8	15
Purslane	5	15
Pycnogenol (Pine Bark)	4	15
Saikosaponin	10	15
Shikonin	10	15
Allicin	8	14
Artesunate	9	14
Ashwagandha	8	14
Astragalus	6	14
Baicalein	10	14
Cordyceps Militaris	9	14
Deguelin	8	14
Honeysuckle	9	14
Horse Chestnut	9	14
NAC (N-acetyl-L-cysteine)	9	14
Nigella sativa (aka Black Seed)	4	14
Probiotics	8	14
Selenium	8	14
Verbascoside	8	14
Bilberry	3	13
Carnosine	3	13
Celastrol	7	13
Fermented Foods and Beverages	8	13
Gastrodin	8	13
Glycyrrhizin	9	13
Isothiocyanates	9	13
Lactobacillus Acidophilus	3	13
Neem	10	13
Oleuropein	8	13
Palmitoylethanolamide	6	13
Phlorotannins	10	13
Rutin	8	13
Scopoletin	8	13
Sesamol	8	13
Strawberry	4	13
Aloe Vera	8	12
Black Raspberry	2	12
Bromelain	9	12
Carnosic Acid	7	12
Citrus Triterpenoids	5	12
Eugenol	10	12
Fruit: All	2	12
Hydroxytyrosol	7	12
Lactobacillus rhamnosus GG	5	12
Vitamin E: alpha tocopherol	5	12
Vitexins	7	12
Bisdemethoxycurcumin	7	11
Carnosol	6	11
Cinnamaldehyde	8	11
Medicinal Mushrooms	7	11
Phellinus Linteus	8	11
Rosemaric Acid	6	11
Sesamin	7	11
Sweet Potato: Purple	6	11
Tangeretin	7	11
Tocotrienols	2	11
Vitamin E	7	11
Zerumbone	7	11
Bamboo	6	10
Capsaicin	8	10
Carvacrol	6	10
Chicoric Acid	6	10
Diosmetin	6	10
Eriodictyol	6	10
Frankincense	8	10
Lactobacillus delbrueckii Subsp	1	10
Orange	1	10
Organosulfur Compounds	5	10
Phenethyl isothiocyanate	8	10
Procyanidin B2	8	10
Sea buckthorn	5	10
Syringic Acid	5	10
Vanillic Acid	7	10
Yoghurt	1	10
Zyflamend	1	10
Acai	4	9
Arctigenin	6	9
Burdock	6	9
Cardamonin	6	9
Catechin	8	9
Cucurbitacin E	6	9
Garlic: Aged	4	9
Guduchi	3	9
Oridonin	8	9
Perilla	5	9
acetyl-11-keto-beta-boswellic acid	5	9
Angelica	3	8
Apple Polyphenols	5	8
Bifidobacterium Longum	4	8
Carotenoids	6	8
Chokeberry	5	8
Chrysanthemum Indicum	6	8
Citral	3	8
Gallic Acid	6	8
Goji	5	8
Indole-3-Carbinol	5	8
Lion's Mane (Hericium Erinaceus)	5	8
Lutein	5	8
Nexrutine (Phellodendrom)	4	8
Nicotinamide Mononucleotide	3	8
Panax Notoginseng	5	8
Rooibos	4	8
Safranal	4	8
Walnut	5	8
Barley	2	7
Beta-Caryophyllene	5	7
Betaine	4	7
Bitter Melon	4	7
Chinese Skullcap	4	7
Crocetin	4	7
Curcumol	7	7
DHA (Docosahexaenoic Acid)	4	7
Flaxseed	4	7
Helenalin	6	7
Honey	5	7
Hydrogen: Molecular	4	7
Omega-3 Fatty Acids	5	7
Raspberry	4	7
Triptolide	5	7
Urolithin A	4	7
Vanillin	5	7
Arginine	3	6
Arnica	6	6
Artemisinin	5	6
Babchi	4	6
Bifidobacterium Bifidum	3	6
Cyanidin	4	6
Delphinidin	3	6
EPA (Eicosapentaenoic Acid)	3	6
Folic Acid	3	6
Garcinia kola	3	6
Ginseng (Siberian)	3	6
Gotu Kola	4	6
Kimchi	4	6
Lactobacillus casei	3	6
Liquiritigenin	4	6
Noni	4	6
Oats	4	6
Oleanolic acid	4	6
Oleocanthal	2	6
Oligonol	4	6
Olive	4	6
Persimmon	5	6
Rosemary	4	6
Royal Jelly	4	6
Thymol	3	6
White Tea	3	6
Apples	3	5
Berbamine	4	5
Blackberry	3	5
Caffeic Acid	3	5
Citicoline	3	5
Coenzyme Q10	4	5
Corn Silk	3	5
Cryptoxanthin	3	5
Daidzein	3	5
Demethoxycurcumin	5	5
Diallyl sulfide	3	5
Feverfew	5	5
Gynostemma	3	5
Hawthorn	3	5
Kiwifruit	3	5
Krill	3	5
Lactobacillus reuteri	3	5
Magnesium	3	5
Magnolia	4	5
Maqui	1	5
Oyster Mushroom	3	5
Parsley	1	5
Plantago	4	5
Stigmasterol	2	5
Tart Cherry	3	5
Theanine	3	5
Tocotrienol: Delta	3	5
Tomatidine	3	5
Toona sinensis	3	5
Vitamin K2	4	5
Wasabi	3	5
Adlay	4	4
Arugula	2	4
Benzyl isothiocyanate	3	4
Bergamot	3	4
Cordyceps sinensis	2	4
Cucurbitacin B	3	4
Damnacanthal	3	4
Fig	2	4
Guava	3	4
Histidine	2	4
Huperzine	3	4
Hyperforin	4	4
Isothiocyanate	2	4
Jambul	2	4
Jujube	3	4
Kefir	2	4
Ketone Bodies	2	4
Lactobacillus gasseri	2	4
Lactobacillus sakei	2	4
Lavender: Essential Oil	3	4
Lignans	4	4
Loquat	3	4
Maitake Mushroom	3	4
Mangosteen	3	4
Nicotinamide	2	4
Orange: Mandarin	2	4
Rice	2	4
Spikenard	3	4
Sweet Potato	2	4
Tannic Acid	2	4
Taurine	3	4
Tomato	3	4
Tripterygium wilfordii	3	4
Vitamin K	3	4
Xanthones	3	4
Zinc	3	4
Acacia catechu	2	3
Aduki bean	2	3
Amla Fruit	2	3
Apple	2	3
Avocado	2	3
Bergamot orange	2	3
Beta Sitosterol	2	3
Beta-Elemene	3	3
Bitter Orange	3	3
Broccoli Sprouts	3	3
Bufalin	2	3
Cannabis	2	3
Carbon 60	1	3
Celery	2	3
Chlorella (Algae)	2	3
Chlorophyllin	2	3
Cinnamon	2	3
D-Limonene	2	3
Dill	2	3
Epicatechin	2	3
Fenugreek	2	3
Ginseng (American)	2	3
Glycyrrhiza uralensis	2	3
Gold (nanoparticles)	2	3
Grapefruit	2	3
Harmine	2	3
Hemp Seed	3	3
Holy Basil	2	3
Hops	2	3
Lemongrass	2	3
Lingans	1	3
Lingonberry	2	3
Litchi	2	3
Mango	2	3
Myrrh	2	3
Nutmeg	2	3
Oligosaccharides	2	3
Palm Oil	2	3
Papaya	3	3
Phyllanthus amarus	3	3
Pine Bark Extract	3	3
Piperidines	1	3
Proanthocyanidins	2	3
Rice Bran	2	3
Saffron	2	3
Schisandra	3	3
Silymarin	2	3
Soy	2	3
Terminalia	1	3
Theaflavins	2	3
Thistle	3	3
Tocotrienol: Gamma	2	3
Vitamin E: Gamma-Tocopherol	2	3
Vitamin E: Gamma-tocotrienol	3	3
White Mulberry	2	3
neohesperidin	2	3
18β-Glycyrrhetinic Acid	1	2
2-Methoxyestradiol	1	2
4-Shogaol	2	2
Agrimony	2	2
Amygdalin	2	2
Amygdalin (laetrile)	2	2
Anemarrhena asphodeloides	1	2
Antrodia Camphorate	1	2
Apricot	1	2
Artichoke	2	2
Bai Zhu	1	2
Banana Stem	1	2
Barberry	1	2
Basil	1	2
Bee Pollen	1	2
Bifidobacterium Breve	1	2
Bitter Apple	1	2
Black Cohosh	1	2
Black Currant	1	2
Black Pepper	2	2
Buckwheat	1	2
Camel Milk	1	2
Cashew	2	2
Cat's Claw	2	2
Catechols	2	2
Celery Oil	1	2
Chia	1	2
Chondroitin Sulfate	1	2
Chrysanthemum Morifolium	1	2
Citrus Peel	1	2
Coffee	1	2
Coptis chinensis	1	2
Coriandrum sativum	1	2
Corn: Purple	1	2
Cranberry	1	2
Curcumin: Degradiation byproducts	2	2
Cyanidin 3-glucoside	2	2
Dates	1	2
Dopa bean	1	2
Elm tree	1	2
Epimedium	1	2
Eucalyptus	2	2
Evening Primrose Oil	1	2
Fennel	1	2
Fiber	1	2
Fish Oil	1	2
Flavan-3-ols	1	2
Flaxseed Oil	1	2
Galactooligosaccharides	1	2
Garcinia Mangostana	1	2
Gardenia	1	2
Glucosamine	1	2
Glycyrrhiza glabra	1	2
Hibiscus	2	2
Hibiscus sabdariffa	1	2
Hyssop	1	2
Indigo Naturalis	1	2
Inulin	1	2
Isoquercitrin	1	2
Kaempferia parviflora	1	2
Kudzu	1	2
L-arginine	1	2
Lactobacillus probiotics	1	2
Lactobacillus rhamnosus	2	2
Lemon Balm	1	2
Lentinan	1	2
Lithospermum erythrorhizon	2	2
Long Pepper	1	2
MSM (Methylsulfonylmethane)	1	2
Maca	1	2
Mango leaf	1	2
Manuka Honey	1	2
Marjoram	2	2
Medium Chain Triglycerides	1	2
Milk Thistle	1	2
Mint	1	2
Modified Citrus Pectin	1	2
Mucuna pruriens (aka Velvet Beans)	1	2
Mululuza	2	2
Mung Bean	1	2
Mushrooms: All	2	2
Myrtenol	1	2
Niacin	1	2
Nicotinamide adenine dinucleotide (NADH)	1	2
Nordihydroguaiaretic acid (NDGA)	1	2
Okra	1	2
Oolong tea	1	2
Orthosiphon	1	2
Pea	1	2
Peach	1	2
Pelargonium sidoides	1	2
Perillaldehyde	2	2
Phyllanthus emblica	1	2
Phyllanthus urinaria	2	2
Pineapple	1	2
Plantago asiatica	1	2
Potato	1	2
Potato: Pigmented	1	2
Propolis: Bee	1	2
Propolis: Brazillian	1	2
Psychedelics:All	2	2
Raspberry ketone	1	2
Red Sage	1	2
Rhubarb	2	2
Rubia Cordifolia	1	2
Saccharomyces Boulardii	1	2
Saturated fatty acids	1	2
Sea Cucumber	1	2
Seaweed	1	2
Shiitake Mushroom	1	2
Shitake Mushroom	1	2
Soy: Fermented	1	2
Soybean: Black	1	2
Terminalia chebula	1	2
Testosterone	1	2

[+]

Aerobic training and purslane seed ere effective in the regulation of diabetic biomarkers associated with atherosclerosis in women with T2D.Dec 04, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2016 Dec 5 ;6:37819. Epub 2016 Dec 5. PMID: 27917862

Article Published Date : Dec 04, 2016

Substances : Fruit: All

Diseases : Inflammation, Obesity

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

Additional Keywords : Risk Reduction

[+]

Genistein and puerarin could inhibit the pathway of NF-kappaB and TNF-alpha in asthma patients.Jan 31, 2010

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Pubmed Data : Pharmazie. 2010 Feb ;65(2):127-31. PMID: 20225658

Article Published Date : Jan 31, 2010

Study Type : Human Study

Additional Links

Substances : Genistein, Puerarin

Diseases : Asthma

Pharmacological Actions : Antioxidants, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vasodilator Agents

[+]

Ginger can improve rheumatoid arthritis by decreasing disease manifestations in patients.May 24, 2019

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Pubmed Data : Gene. 2019 May 25 ;698:179-185. Epub 2019 Mar 4. PMID: 30844477

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Pubmed Data : Phytother Res. 2019 Jul 1. Epub 2019 Jul 1. PMID: 31264313

Article Published Date : Jun 30, 2019

Study Type : Human Study

Additional Links

Substances : Hesperidin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor

[+]

Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults.Jan 21, 2020

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Pubmed Data : Metab Syndr Relat Disord. 2018 Jun 29. Epub 2018 Jun 29. PMID: 29957104

Article Published Date : Jun 28, 2018

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Diabetes Mellitus: Type 2

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Puerarin acts as an anti-inflammatory agent by blocking NF-kappaB signalling.Jul 31, 2010

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Pubmed Data : Phytother Res. 2017 Mar 9. Epub 2017 Mar 9. PMID: 28276100

Article Published Date : Mar 08, 2017

Study Type : Human In Vitro

Additional Links

Substances : Pomegranate

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chondroprotective, Interleukin-6 Downregulation, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

[+]

Alpha-bisobolol inhibits lipopolysaccharide-induced inflammation.Oct 01, 2011

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Pubmed Data : Food Chem Toxicol. 2011 Oct ;49(10):2580-5. Epub 2011 Jul 13. PMID: 21771629

Article Published Date : Oct 01, 2011

Study Type : Human In Vitro

Additional Links

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

[+]

Apigenin could be a useful compound to prevent proliferation and migration of cancer cells as well as cancer stem cells.Aug 24, 2016

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Pubmed Data : Life Sci. 2016 Aug 25. Epub 2016 Aug 25. PMID: 27569589

Article Published Date : Aug 24, 2016

Study Type : Human In Vitro

Additional Links

Substances : Apigenin

Diseases : Prostate Cancer, Prostate Cancer Stem Cells

Pharmacological Actions : Anti-metastatic, Antiproliferative , NF-kappaB Inhibitor

Additional Keywords : Dose Response

[+]

Apigenin highly upregulated the expression of cytokine genes and induced apoptosis in human pancreatic cancer cells.Nov 30, 2013

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Pubmed Data : Mol Nutr Food Res. 2013 Dec ;57(12):2112-27. Epub 2013 Aug 14. PMID: 23943362

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Pubmed Data : J Periodontol. 2006 Feb ;77(2):271-9. PMID: 16460254

Article Published Date : Feb 01, 2006

Study Type : Human In Vitro

Additional Links

Diseases : Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Epigenetic upregulation of metallothionein 2A by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel.Jan 21, 2016

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Pubmed Data : Antioxid Redox Signal. 2016 Jan 22. Epub 2016 Jan 22. PMID: 26801633

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Pubmed Data : Biochem Pharmacol. 2017 Mar 15 ;128:26-33. Epub 2016 Dec 23. PMID: 28017776

Article Published Date : Mar 14, 2017

Study Type : Human In Vitro

Additional Links

Substances : Nobiletin

Diseases : Cholesterol: Oxidation, Oxidative Stress

Pharmacological Actions : Antithrombotic, Cardiovascular Agents, NF-kappaB Inhibitor

[+]

These results indicate the potential for açai polyphenolics in the prevention of intestinal inflammation.Oct 06, 2015

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Pubmed Data : Food Funct. 2015 Oct 7 ;6(10):3249-56. PMID: 26243669

Article Published Date : Oct 06, 2015

Study Type : Human In Vitro

Additional Links

Substances : Acai

Diseases : Gastrointestinal Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response

[+]

These results suggest deguelin could have potential for the treatment of human CLL.Dec 31, 2015

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Pubmed Data : Mol Med Rep. 2022 Jul ;26(1). Epub 2022 May 20. PMID: 35593299

Article Published Date : Jun 30, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Carnosol

Diseases : Osteoporosis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Chlorogenic acid may be a viable therapeutic option for bacterial and viral-induced acute respiratory distress syndrome-like pathology.May 30, 2023

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Pubmed Data : Cell Death Dis. 2022 Jun 17 ;13(6):554. Epub 2022 Jun 17. PMID: 35715415

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Pubmed Data : Int J Mol Sci. 2018 Jul 13 ;19(7). Epub 2018 Jul 13. PMID: 30011811

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Lupeol alleviates autoimmune myocarditis.Nov 07, 2023

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Pubmed Data : Sci Rep. 2024 Aug 8 ;14(1):18390. Epub 2024 Aug 8. PMID: 39117680

Article Published Date : Aug 07, 2024

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Paeonol

Diseases : Oxidative Stress, Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Palmitoylethanolamide ameliorates neuroinflammation.Jun 10, 2022

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Salvianolic acid B attenuates the inflammatory response in atherosclerosis.Dec 31, 2021

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Pubmed Data : Eur J Pharmacol. 2020 Sep 5 ;882:173264. Epub 2020 Jun 13. PMID: 32544504

Article Published Date : Sep 04, 2020

Study Type : Animal Study

Additional Links

Substances : Vitexins

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, NF-kappaB Inhibitor

[+]

"Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats."Dec 01, 2008

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Pubmed Data : Clinics (Sao Paulo). 2008 Dec ;63(6):807-13. PMID: 19061005

Article Published Date : Dec 01, 2008

Study Type : Animal Study

Additional Links

Substances : Ginger

Diseases : Liver Cancer: Prevention

Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

"Tanshinone IIA prevents uric acid nephropathy in rats through NF-κB inhibition."May 31, 2012

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Pubmed Data : Planta Med. 2012 Jun ;78(9):866-73. Epub 2012 May 15. PMID: 22588836

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Pubmed Data : Hum Exp Toxicol. 2018 Jan 1:960327117751235. Epub 2018 Jan 1. PMID: 29350052

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Gingerol

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor

[+]

6-shogaol against 3-Nitropropionic acid-induced Huntington's disease.Dec 31, 2023

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2024 ;19(7):e0305358. Epub 2024 Jul 15. PMID: 39008492

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : 6-Shogaol

Diseases : Huntington Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Pubmed Data : Oncotarget. 2016 Nov 21. Epub 2016 Nov 21. PMID: 27888812

Article Published Date : Nov 20, 2016

Study Type : Animal Study, In Vitro Study

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Substances : Shiitake Mushroom

Diseases : Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Caspase-3 Activation, NF-kappaB Inhibitor

Additional Keywords : Polysaccharides

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A water-soluble extract from Actinidia arguta ameliorates psoriasis-like skin inflammation.Oct 01, 2018

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Pubmed Data : Nutrients. 2018 Oct 2 ;10(10). Epub 2018 Oct 2. PMID: 30279326

Pubmed Data : Biol Trace Elem Res. 2017 Mar ;176(1):192-200. Epub 2016 Aug 25. PMID: 27561292

Article Published Date : Feb 28, 2017

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Alpha-lipoic acid downregulates TRPV1 receptor via NF-κB and attenuates neuropathic pain in rats with diabetes.Mar 15, 2020

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Pubmed Data : Life Sci. 2022 Sep 15 ;305:120769. Epub 2022 Jul 2. PMID: 35792182

Article Published Date : Sep 14, 2022

Study Type : Animal Study

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Substances : Lupeol

Diseases : Diabetes Mellitus: Type 1

Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ameliorative effect of aspalathin and nothofagin from rooibos on HMGB1-induced septic responses.Dec 31, 2014

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Pubmed Data : Am J Chin Med. 2015 ;43(5):991-1012. Epub 2015 Jul 30. PMID: 26224030

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Pubmed Data : J Ethnopharmacol. 2021 Mar 1 ;267:113503. Epub 2020 Oct 19. PMID: 33091488

Article Published Date : Feb 28, 2021

Study Type : Animal Study

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Substances : Horse Chestnut

Diseases : Neuropathic Pain, Sciatic Nerve Crush Injury

Pharmacological Actions : Analgesics, Neuritogenic, NF-kappaB Inhibitor

[+]

An aqueous extract of bamboo exerts anti-metastatic effects on highly malignant cancer.Dec 31, 2012

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Pubmed Data : PLoS One. 2013 ;8(10):e78061. Epub 2013 Oct 28. PMID: 24205091

Article Published Date : Dec 31, 2012

Study Type : Animal Study

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Substances : Bamboo

Diseases : Cancer Metastasis, Lung Cancer

Pharmacological Actions : Anti-metastatic, Antineoplastic Agents, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

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An ethanolic extract of Arctium lappa L. leaves ameliorates experimental atherosclerosis.May 09, 2024

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Pubmed Data : J Ethnopharmacol. 2024 May 10 ;325:117768. Epub 2024 Jan 20. PMID: 38253275

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:9086747. Epub 2018 Jun 25. PMID: 30046380

Article Published Date : Dec 31, 2017

Study Type : Animal Study

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Substances : Andrographolide

Diseases : Cardiomyopathy

Pharmacological Actions : Antioxidants, Apoptotic, Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Superoxide Dismutase Up-regulation

[+]

Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation.Mar 31, 2015

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Pubmed Data : Biochim Biophys Acta. 2015 Apr ;1850(4):824-31. Epub 2015 Jan 29. PMID: 25641276

Article Published Date : Mar 31, 2015

Study Type : Animal Study

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Substances : Andrographis

Diseases : Diabetic Retinopathy

Pharmacological Actions : Anti-Angiogenic, Anti-Inflammatory Agents, NF-kappaB Inhibitor, Vascular Endothelial Growth Factor Inhibitors

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[+]

Anthocyanins derived from Vitis coignetiae Pulliat contributes anti-cancer effects in Hep3B human hepatocellular carcinoma cells.Nov 19, 2020

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Pubmed Data : Molecules. 2020 Nov 20 ;25(22). Epub 2020 Nov 20. PMID: 33233701

Article Published Date : Nov 19, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Anthocyanins

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor

Additional Keywords : Plant Extracts

[+]

Anthocyanins from purple sweet potato and purple potato are good source of anti inflammatory phytochemicals to prevent alcoholic liver disease.Mar 15, 2015

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2021 Aug 10 ;22(16). Epub 2021 Aug 10. PMID: 34445305

Article Published Date : Aug 09, 2021

Study Type : Animal Study

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Substances : Allicin

Diseases : Hypertension: Pulmonary

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Anti-inflammatory effect of Centella asiatica phytosome in a mouse model of phthalic anhydride-induced atopic dermatitis.Mar 31, 2018

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Pubmed Data : Phytomedicine. 2018 Apr 1 ;43:110-119. Epub 2018 Apr 6. PMID: 29747743

Article Published Date : Mar 31, 2018

Study Type : Animal Study

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Substances : Gotu Kola

Diseases : Atopic Dermatitis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor

[+]

Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo.Apr 26, 2017

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Pubmed Data : BMC Complement Altern Med. 2017 Apr 27 ;17(1):233. Epub 2017 Apr 27. PMID: 28449676

Article Published Date : Apr 26, 2017

Study Type : Animal Study

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Substances : Curcumin, Ligustrazine, Resveratrol

Diseases : Arthritis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Anti-inflammatory effect of Musa acuminata stem. Feb 29, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2016 Sep 18 ;8(9). Epub 2016 Sep 18. PMID: 27649243

Article Published Date : Sep 17, 2016

Study Type : Animal Study

Additional Links

Substances : Plantago asiatica

Diseases : Diabetic Retinopathy

Pharmacological Actions : Antioxidants, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.Apr 30, 2017

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Pubmed Data : Environ Toxicol. 2023 Feb ;38(2):253-265. Epub 2022 Nov 9. PMID: 36350155

Article Published Date : Jan 31, 2023

Study Type : Animal Study

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Substances : Apigenin

Diseases : Allergic Rhinitis, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-4 upregulation, NF-kappaB Inhibitor

[+]

Apigenin enhances the anti-tumor effect of gemcitabine. Jan 18, 2008

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Pubmed Data : Cancer Lett. 2008 Jan 18;259(1):39-49. Epub 2007 Oct 29. PMID: 17967505

Article Published Date : Jan 18, 2008

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, NF-kappaB Inhibitor

Additional Keywords : Drug: Gemcitabine, Drug-Plant-Vitamin Synergies

[+]

Apigenin may be an alternative therapeutic option for prevention of sepsis-induced organ damage. May 31, 2016

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Pubmed Data : Immunopharmacol Immunotoxicol. 2016 Jun ;38(3):228-237. PMID: 27144896

Article Published Date : May 31, 2016

Study Type : Animal Study

Additional Links

Substances : Apigenin

Diseases : Sepsis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-10 upregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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View the Evidence: 3464 Abstracts with NF-kappaB Inhibitor Research

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The immunomodulatory effects of lactoferrin and its derived peptides on NF-κB signaling pathway.Jul 31, 2023

Protective role of baicalin in the dynamic progression of lung injury to idiopathic pulmonary fibrosis.May 31, 2023

Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients.Dec 31, 2022

Aerobic training and purslane seed ere effective in the regulation of diabetic biomarkers associated with atherosclerosis in women with T2D.Dec 04, 2016

Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes.Oct 01, 2010

Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation.Jan 31, 2019

Bilberry has anti-inflammatory properties.Sep 01, 2010

Blood orange juice intake modulates plasma and PBMC microRNA expression in overweight and insulin resistance women.Nov 24, 2022

Cashew may have anti-inflammatory activity in rheumatoid arthritis patients.Dec 06, 2006

Chondroprotective properties of human-enriched serum following polyphenol extract absorption.Dec 15, 2019

Consumption of Nigella sativa can reduce the inflammatory biomarkers in patients with NAFLD.May 31, 2019

Curcumin selectively induces programmed cell death in cutaneous T-cell lymphoma cell lines and in peripheral blood mononuclear cells (PBMCs).Aug 01, 2010

Curcuminoid supplementation for twelve weeks attenuates lipid peroxidation and might reduce uremic toxin in patients with chronic kidney disease undergoing peritoneal dialysis.Jan 31, 2024

Dietary strawberries significantly decreased the histologic grade of patients' precancerous esophageal lesions.Dec 31, 2011

Effect of berberine on activation of TLR4-NFκB signaling pathway and NLRP3 inflammasome in patients with gout.Sep 19, 2022

French maritime pine bark extract (Pycnogenol) displays anti-inflammatory effects in vivo.Jan 01, 2006

Fruit and vegetable juice concentrate may be beneficial for improving the metabolic profile in obese individuals. Feb 07, 2017

Genistein and puerarin could inhibit the pathway of NF-kappaB and TNF-alpha in asthma patients.Jan 31, 2010

Ginger can improve rheumatoid arthritis by decreasing disease manifestations in patients.May 24, 2019

Ginsenoside Rd is efficacious against acute ischemic stroke.Apr 30, 2016

Green tea induced changes in NFκB and systemic oxidation, and uptake of GT polyphenols in prostate tissue they may have a role in prostate cancer prevention and treatment.Mar 31, 2015

Hesperidin supplementation accompanied with lifestyle modification is superior to lifestyle modification alone in management of NAFLD.Jun 30, 2019

Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults.Jan 21, 2020

Hyperbaric oxygen therapy regulated the inflammatory reaction in secondary spinal cord injury.Oct 31, 2018

Inflammatory markers response to crocin supplementation in patients with type 2 diabetes mellitus.Apr 14, 2021

L-carnosine protects against oxaliplatin-induced peripheral neuropathy in colorectal cancer patients.Feb 14, 2019

Lactobacillus acidophilus modulates inflammatory activity by regulating the TLR4 and NF-κB expression in porcine peripheral blood mononuclear cells.Feb 27, 2016

Low-fat yogurt for 9 weeks reduced biomarkers of chronic inflammation and endotoxin exposure in premenopausal women.Nov 30, 2017

Lyophilized black raspberries significantly decreased urinary lipid peroxidation levels and significantly increased GST-pi, a marker of detoxification.Jul 06, 2016

Olive oil consumption has an ameliorative effect in non-alcoholic fatty liver disease.Apr 21, 2009

Oral supplementation with probiotics could be helpful in maintaining remission and preventing relapse of ulcerative colitis.Sep 06, 2010

Plasma anthocyanins and their metabolites reduce in vitro migration of pancreatic cancer cells.Jan 31, 2023

Pomegranate juice increases sirtuin1 protein in peripheral blood mononuclear cell from patients with type 2 diabetes.Jun 28, 2018

Puerarin acts as an anti-inflammatory agent by blocking NF-kappaB signalling.Jul 31, 2010

Puerarin: A potential therapeutic for SARS-CoV-2 and hantavirus co-infection. Dec 31, 2021

Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats.Jan 01, 2017

Resveratrol and genistein may be potential drugs candidates for use in the treatment of COPD.Mar 27, 2016

Resveratrol could be a potential therapeutic target for intrahepatic cholestasis of pregnancy.May 31, 2018

Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in monocytes from pregnant women with preeclampsia.Apr 18, 2019

Sudharshan kriya pranayama can significantly decrease periodontal inflammation and improve periodontal status.Feb 05, 2020

The effect of Brazilian Green Propolis extract on inflammation in patients with chronic kidney disease.May 31, 2023

The inhibitory effects of curcumin support its utility as a prophylactic and therapeutic agent for inflammatory bone diseases such as periodontitis.Jul 31, 2015

Thoughts modulate the expression of inflammatory genes and may improve the coronary blood flow in patients after a myocardial infarction.Dec 31, 2017

Three months treatment with curcumin in chronic kidney disease patients undergoing hemodialysis resulted in decreased markers of inflammation.Mar 12, 2020

Vitamin D reduces clinical and metabolic symptoms in end-stage renal disease.May 30, 2022

Zyflamend (a multi-herbal formula) has significant therapeutic activity in treating high-grade prostatic intraepithelial neoplasia. Mar 01, 2009

Activation of Sirtuin3 by honokiol ameliorates alveolar epithelial cell senescence in experimental silicosis.Jul 31, 2024

A Polyphenol-rich pomegranate fruit extract suppresses NF-κB and IL-6 expression.Mar 08, 2017

Alpha-bisobolol inhibits lipopolysaccharide-induced inflammation.Oct 01, 2011

Ammi visnaga, parsley, barley, and camel's grass all display renoprotective effects.Jun 25, 2019

Angelica and Astragalus could protect against oxidative stress-induced apoptosis in kidney epithelium.Feb 16, 2016

Anthocyanins from wild blueberry reduce the activation of NF-kB and mitigate IL-1B activity human intestinal cells.Aug 20, 2014

Antioxidant mixtures could prevent the harmful effects of ozone induced oxidative stress in human keratinocytes.Dec 31, 2014

Apigenin could be a useful compound to prevent proliferation and migration of cancer cells as well as cancer stem cells.Aug 24, 2016

Apigenin highly upregulated the expression of cytokine genes and induced apoptosis in human pancreatic cancer cells.Nov 30, 2013

Caffeic acid phenethyl ester could be effective for treating of periodontal diseases.Nov 06, 2016

Citral inhibits LPS-induced inflammatory response via activating PPAR-γ which attenuates NF-κB activation.Dec 10, 2015

Combination treatments with luteolin and fisetin may be a potential candidate for the treatment and prevention of diabetes and its complications.Jun 25, 2017

Curcumin might prevent early bacterial or virus infection into the lumen of the intestine or reduce the degree of the infection by inhibiting the inflammatory response.Mar 31, 2015

Diallyl disulfide could be a promising anticancer agent for anti-metastatic treatment of esophageal-gastric junction adenocarcinoma in the future.Jan 31, 2018

Ecklonia cava extract exerts anti-inflammatory effect in human gingival fibroblasts and chronic periodontitis animal model.Jul 16, 2021

Elderflower inhibits all pro-inflammatory activities of major periodontal pathogens.Feb 01, 2006

Epigenetic upregulation of metallothionein 2A by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel.Jan 21, 2016

Ganoderic acids suppress growth and invasive behavior of breast cancer cells.Apr 30, 2008

Lactobacillus rhamnosus GG conditioned medium prevents E. coli meningitis by inhibiting nuclear factor-κB pathway.Jan 19, 2017

Low-power laser irradiation suppresses inflammatory response of human adipose-derived stem cells.Dec 31, 2012

Maqui berry and ginseng extracts reduce cigarette smoke-induced cell injury.Dec 13, 2022

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Nexrutine as an agent to potentiate the therapeutic response of docetaxel by suppressing activation of c-FLIP and its upstream regulators.May 08, 2017

Oleocanthal inhibits catabolic and inflammatory mediators in LPS-activated human primary osteoarthritis chondrocytes.Dec 31, 2017

Oligonol suppresses inflammatory cytokine production from human monocytes.May 31, 2016

Olive oil compounds inhibit the effect of the chronic inflammatory microenvironment on glioblastoma progression.Aug 31, 2015

NF-kappaB Inhibitor

View the Evidence:
3464 Abstracts with NF-kappaB Inhibitor Research