Nrf2 activation

Name	AC	CK
Sulforaphane	69	132
Curcumin	29	50
Astaxanthin	23	38
Flavonoids	18	38
Broccoli Sprouts	7	36
Luteolin	19	35
Ginsenosides	21	33
Pterostilbene	17	26
Astragaloside	16	25
Isothiocyanates	10	23
EGCG (Epigallocatechin gallate)	13	22
Polyphenols	12	21
Apigenin	9	20
Vitamin B-5 (Pantothenic Acid)	2	20
Melatonin	13	19
Naringenin	14	19
Crocin	10	18
Isoliquiritigenin	9	18
Lycopene	13	18
Tanshinone IIA	13	18
Quercetin	11	17
Berberine	11	16
Grape Seed Extract	8	16
Hesperidin	9	16
Myricetin	9	16
Paeoniflorin	10	16
Puerarin	10	16
Thymoquinone	10	16
Punicalagin	9	15
Fucoxanthin	9	14
Chlorogenic Acid	8	13
Dandelion	9	13
Mangiferin	8	13
Aloe Vera	2	12
Eriodictyol	8	12
Resveratrol	8	12
Carnosic Acid	7	11
Carnosine	2	11
Fisetin	8	11
Rosemaric Acid	7	11
Bilberry	1	10
Biochanin A	6	10
Cinnamaldehyde	6	10
Coenzyme Q10	6	10
Ellagic Acid	6	10
Ferulic acid	7	10
Green Tea	1	10
Hydrogen Water	5	10
Lotus	7	10
Mangosteen	1	10
Riboflavin (Vitamin B-2)	1	10
Asiatic Acid	5	9
Caffeic acid phenethyl ester	3	9
Formononetin	5	9
Gastrodin	6	9
Ginseng (Korean)	5	9
Paeonol	5	9
Piceatannol	6	9
Xanthohumol	6	9
Anthocyanins	6	8
Blueberry	5	8
Emodin	5	8
Genistein	5	8
Grape	5	8
Indole-3-Carbinol	5	8
Licorice	6	8
Ligustrazine	4	8
Zinc	5	8
Allicin	4	7
Alpha-Lipoic Acid	4	7
Blue Honeysuckle	4	7
Chokeberry	2	7
Chrysin	4	7
Crocetin	4	7
Delphinidin	2	7
Lutein	4	7
Moringa oleifera	4	7
NAC (N-acetyl-L-cysteine)	2	7
P-Coumaric Acid	4	7
Panax Notoginseng	5	7
Safflower	4	7
Sesamin	2	7
Wogonin	4	7
Chaga Mushroom (Inonotus obliquus)	3	6
Geraniol	3	6
Gotu Kola	4	6
Honokiol	4	6
Royal Jelly	3	6
Rutin	3	6
Turmeric	4	6
Vitamin C	4	6
Apple	3	5
Carotenoids	4	5
Fennel	1	5
Fucoidan	3	5
Garlic	3	5
Garlic: Aged	1	5
Genipin	3	5
Ginger	3	5
Gingerol	3	5
Hemp Seed	4	5
Lactobacillus plantarum	3	5
Okra	3	5
Olive Oil	3	5
Oridonin	3	5
Procyanidin B2	3	5
Red Sage	3	5
Vitexins	4	5
Cinnamon	2	4
Diosmetin	3	4
Dogwood	2	4
Hydroxytyrosol	3	4
Phloretin	3	4
Pomegranate	2	4
Proanthocyanidins	2	4
Radish	3	4
Rooibos	2	4
Schisandra	2	4
Seaweed: Brown	2	4
Selenium	2	4
Sesamol	3	4
Silymarin	3	4
Strawberry	3	4
Tangeretin	3	4
Theaflavins	2	4
Verbascoside	2	4
Zeaxanthin	2	4
Zerumbone	3	4
acetyl-11-keto-beta-boswellic acid	2	4
6-Shogaol	3	3
Alpha Linolenic Acid	3	3
Bamboo	2	3
Betulinic acid	2	3
Black Pepper	2	3
Butterbur	2	3
Cardamonin	2	3
Carnosol	2	3
Cashew	2	3
Citrus Peel	2	3
Cocoa	2	3
Fermented Foods and Beverages	2	3
Ginkgo biloba	2	3
Ginseng	2	3
Glycyrrhizin	2	3
Goji	2	3
Honey	2	3
Hydrangea	2	3
Kaempferol	3	3
Kiwifruit	2	3
Lion's Mane (Hericium Erinaceus)	3	3
Perillaldehyde	2	3
Rose	2	3
Rosmarinic acid	2	3
Salvia miltiorrhiza	2	3
Sea buckthorn	2	3
Silibinin	2	3
Sweet Potato: Purple	2	3
Tetrahydrocurcumin	2	3
Thymol	2	3
Achiote	1	2
Alpha Ketoglutarate	1	2
Andrographolide	1	2
Artemisia asiatica	1	2
Artesunate	1	2
Avenanthramides	2	2
Bacopa	1	2
Banaba	1	2
Bee Propolis	1	2
Bee Venom	1	2
Beet	1	2
Benzyl isothiocyanate	1	2
Betanins	1	2
Bitter Orange	1	2
Buckwheat	1	2
Chia	1	2
Chlorophyllin	1	2
Citral	1	2
Citrus naringin	2	2
Coffee	2	2
Cordyceps Militaris	1	2
Corn Silk	1	2
Cranberry	1	2
Cryptoxanthin	1	2
Cysteine (see N-Acetylcysteine)	1	2
DHA (Docosahexaenoic Acid)	1	2
Deguelin	1	2
Diallyl sulfide	1	2
Dibenzoylmethane (DBM)	1	2
Echinacea	1	2
Elderberry	2	2
Eucalyptus	1	2
Ginseng (Siberian)	1	2
Glycyrrhiza uralensis	1	2
Grapefruit	1	2
Guduchi	1	2
Hawthorn	1	2
Isoflavones	1	2
Jujube	1	2
Kahweol	2	2
Krill	1	2
Lactobacillus fermentum	1	2
Lactobacillus rhamnosus GG	1	2
Lavender	1	2
Lavender: Essential Oil	1	2
Lemon Balm	1	2
Lupeol	1	2
Magnolol	1	2
Medicinal Mushrooms	1	2
Niacin	1	2
Nicotinamide	1	2
Nobiletin	1	2
Nordihydroguaiaretic acid (NDGA)	1	2
Nutmeg	1	2
Oats	2	2
Olive leaf extract	1	2
Omega-3 Fatty Acids	1	2
Orange: Mandarin	1	2
Organosulfur Compounds	1	2
Parthenolide	1	2
Phellinus Linteus	2	2
Phenethyl isothiocyanate	2	2
Phlorotannins	1	2
Prickly Pear Cactus	1	2
Probiotics	1	2
Propolis: Brazillian	1	2
Raspberry	1	2
Raspberry ketone	1	2
Safranal	1	2
Sandalwood	1	2
Seaweed	1	2
Soursop	2	2
Stevia	1	2
Ursolic Acid	1	2
Vitamin E: Gamma-Tocopherol	1	2
Vitamin E: alpha tocopherol	2	2
Xanthones	1	2
Yeast	1	2
Zataria multiflora	1	2
Adlay	1	1
Amygdalin (laetrile)	1	1
Apocynin	1	1
Apple Polyphenols	1	1
Astragalus	1	1
Babchi	1	1
Baicalein	1	1
Barley	1	1
Berbamine	1	1
Berries: All	1	1
Beta Sitosterol	1	1
Beta-Caryophyllene	1	1
Bisdemethoxycurcumin	1	1
Black Currant	1	1
Burdock	1	1
Cabbage	1	1
Cafestol	1	1
Caffeine	1	1
Cannabidiol	1	1
Cannabis	1	1
Carvacrol	1	1
Celastrol	1	1
Cruciferous Vegetables	1	1
Curcuma Longa	1	1
Curcuminoids	1	1
Cyanidin	1	1
Gallic Acid	1	1
Glutathione	1	1
Gold (nanoparticles)	1	1
Graviola	1	1
Haritaki (Terminalia chebula)	1	1
Hibiscus	1	1
Hirudin (from Medicinal Leaches)	1	1
Honeysuckle	1	1
Kimchi	1	1
Kudzu	1	1
Lemon Peel	1	1
Magnolia	1	1
Mango	1	1
Maple	1	1
Noni	1	1
Nuts: All	1	1
Oleocanthal	1	1
Oleuropein	1	1
Papaya: Fermented	1	1
Peony	1	1
Phyllanthus emblica	1	1
Pine Cone	1	1
Piperine	1	1
Poria cocos	1	1
Purslane	1	1
Red Clover	1	1
Reishi Mushroom	1	1
Rhubarb	1	1
Rock-rose	1	1
Rosemary	1	1
Salvia divinorum	1	1
Silver (nanoparticles)	1	1
Star Anise (Illicium anisatum)	1	1
Tauroursodeoxycholic acid	1	1
Terminalia chebula	1	1
Tomato	1	1
Urolithin A	1	1
Vitamin D	1	1
Vitamin E	1	1
Vitamin E: Gamma-tocotrienol	1	1
Walnut	1	1
White Button Mushroom	1	1
beta-Carotene	1	1

[+]

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status.Mar 31, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Free Radic Biol Med. 2018 08 20 ;124:532-540. Epub 2018 Jun 30. PMID: 29969714

Article Published Date : Jan 20, 2018

Study Type : Human In Vitro

Additional Links

Substances : Sulforaphane

Diseases : Oxidative Stress

Pharmacological Actions : Antioxidant Effects, Nrf2 activation

Additional Keywords : Antioxidants, Broccoli, Broccoli Sprouts, Cruciferous Vegetables

[+]

Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes.Feb 29, 2020

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Pubmed Data : Inflamm Res. 2020 Mar ;69(3):309-319. Epub 2020 Jan 30. PMID: 32002586

Pubmed Data : Free Radic Biol Med. 2023 Feb 1 ;195:13-22. Epub 2022 Dec 19. PMID: 36549428

Article Published Date : Jan 31, 2023

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Bisphenol Toxicity

Pharmacological Actions : Antioxidants, Gastroprotective, Nrf2 activation

Problem Substances : Bisphenol A

Adverse Pharmacological Actions : Gastrotoxic

[+]

Multi-target effects of ß-caryophyllene and carnosic acid at the crossroads of mitochondrial dysfunction and neurodegeneration.Jun 17, 2022

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Pubmed Data : Am J Chin Med. 2022 Oct 29:1-27. Epub 2022 Oct 29. PMID: 36309810

Article Published Date : Oct 28, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Pulmonary Fibrosis

Pharmacological Actions : Anti-Fibrotic, Antioxidants, Nrf2 activation

[+]

Baicalin protects LPS-induced blood-brain barrier damage and activates Nrf2-mediated antioxidant stress pathway Jun 30, 2021

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Pubmed Data : Int Immunopharmacol. 2021 Jul ;96:107725. Epub 2021 May 28. PMID: 34162131

Article Published Date : Jun 30, 2021

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Neuroprotective Agents, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide.Sep 30, 2016

Article Publish Status : This is a free article. Click here to read the complete article.

Article Published Date : Feb 28, 2017

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Pubmed Data : Int J Biol Macromol. 2021 Jul 3 ;185:804-812. Epub 2021 Jul 3. PMID: 34229016

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Pubmed Data : Environ Toxicol. 2022 Jan 19. Epub 2022 Jan 19. PMID: 35044701

Article Published Date : Jan 18, 2022

Study Type : Animal Study

Additional Links

Substances : Wogonin

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastrointestinal Agents, Nrf2 activation

[+]

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Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:4054520. Epub 2020 Jan 8. PMID: 31998436

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Chokeberry

Diseases : Alcohol Toxicity , Alcoholic Liver Disease, Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Plant Extracts

[+]

Artemisia extracts were mucoprotective by attenuating stress related mucosal damages.Feb 28, 2015

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Pubmed Data : J Clin Biochem Nutr. 2015 Mar ;56(2):132-42. Epub 2014 Nov 28. PMID: 25759519

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Pubmed Data : Food Funct. 2021 Dec 13 ;12(24):12381-12394. Epub 2021 Dec 13. PMID: 34825683

Article Published Date : Dec 12, 2021

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Astaxanthin ameliorated acetaminophen-induced liver injury.Sep 11, 2022

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Pubmed Data : ACS Appl Mater Interfaces. 2022 Sep 12. Epub 2022 Sep 12. PMID: 36094079

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Pubmed Data : Curr Res Transl Med. 2021 Jan 18 ;69(2):103271. Epub 2021 Jan 18. PMID: 33476935

Article Published Date : Jan 17, 2021

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Stroke

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Astaxanthin attenuates cigarette smoking-induced oxidative stress and inflammation in a sirtuin 1-dependent manner.Feb 28, 2023

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Pubmed Data : J Diabetes Res. 2018 ;2018:6730315. Epub 2018 Mar 21. PMID: 29744366

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Diabetic Nephropathy

Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective

[+]

Astaxanthin promotes Nrf2/ARE signalling to inhibit high glucose induced renal fibrosis in GMCs.Apr 04, 2018

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Pubmed Data : Mar Drugs. 2019 Nov 28 ;17(12). Epub 2019 Nov 28. PMID: 31795292

Article Published Date : Nov 27, 2019

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Chronic Obstructive Pulmonary Disease, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation

[+]

Astaxanthin treatment induces maturation and functional change of myeloid-derived suppressor cells in tumor-bearing mice.Apr 22, 2020

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Pubmed Data : Antioxidants (Basel). 2020 Apr 23 ;9(4). Epub 2020 Apr 23. PMID: 32340271

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Pubmed Data : Molecules. 2018 Aug 14 ;23(8). Epub 2018 Aug 14. PMID: 30110942

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Pubmed Data : Med Sci Monit. 2018 Nov 24 ;24:8481-8488. Epub 2018 Nov 24. PMID: 30471087

Article Published Date : Nov 23, 2018

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Bronchitis

Pharmacological Actions : Antioxidants, Nrf2 activation

[+]

Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy.Dec 31, 2018

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Baicalein pre-treatment alleviates hepatic ischemia/reperfusion injury in mice by regulating the Nrf2/ARE pathway.Nov 30, 2021

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Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1319-1326. Epub 2018 May 7. PMID: 29864914

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Pubmed Data : Int Immunopharmacol. 2016 Sep ;38:324-31. Epub 2016 Jun 23. PMID: 27344638

Article Published Date : Aug 31, 2016

Study Type : Animal Study

Additional Links

Substances : Biochanin A

Diseases : Chemically-Induced Liver Damage, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Bisdemethoxycurcumin attenuated renal injury via activation of Keap1/Nrf2 pathway in high-fat diet.Jul 01, 2022

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Pubmed Data : Int J Mol Sci. 2022 Jul 2 ;23(13). Epub 2022 Jul 2. PMID: 35806399

Article Published Date : Jul 01, 2022

Study Type : Animal Study

Additional Links

Substances : Bisdemethoxycurcumin

Diseases : Chronic Kidney Disease (CKD), High Fat Diet, Oxidative Stress

Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective

[+]

Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney.Dec 31, 2020

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Pubmed Data : Int Immunopharmacol. 2021 Jan ;90:107117. Epub 2020 Nov 6. PMID: 33162346

Article Published Date : Dec 31, 2020

Study Type : Animal Study

Additional Links

Substances : Bixin

Diseases : Kidney Damage: Chemically-Induced, Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective, Superoxide Dismutase Up-regulation

[+]

Bixin attenuates high-fat diet-caused liver steatosis and inflammatory injury.Dec 31, 2020

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Pubmed Data : Korean J Physiol Pharmacol. 2016 Jan ;20(1):15-23. Epub 2015 Dec 31. PMID: 26807019

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2022 Dec ;26(23):8738-8755. PMID: 36524493

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Pubmed Data : J Gerontol A Biol Sci Med Sci. 2022 Mar 12. Epub 2022 Mar 12. PMID: 35279029

Article Published Date : Mar 11, 2022

Study Type : Animal Study

Additional Links

Substances : Chlorogenic Acid

Diseases : Aging

Pharmacological Actions : Antioxidants, Nrf2 activation

Additional Keywords : Gene Expression Regulation

[+]

Chlorogenic acid ameliorates endothelial dysfunction in diabetes.Dec 31, 2020

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Pubmed Data : Cancer Prev Res (Phila). 2015 May ;8(5):444-54. Epub 2015 Feb 23. PMID: 25712056

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Cinnamaldehyde, Cinnamon

Diseases : Colon Cancer: Prevention

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Chemopreventive, Nrf2 activation

[+]

Cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress.Dec 31, 2016

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Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:1583098. Epub 2017 Mar 15. PMID: 28396714

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : High Fat Diet, Hyperlipidemia, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hypolipidemic, Nrf2 activation

Additional Keywords : Plant Extracts

[+]

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Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:7912763. Epub 2020 Feb 6. PMID: 32089779

Article Published Date : Dec 31, 2019

Study Type : Animal Study

Additional Links

Substances : Medicinal Mushrooms

Diseases : Chemotherapy-Induced Kidney Damage, Chemotherapy-Induced Toxicity: Cisplatin

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective

[+]

Cordyceps militaris acidic polysaccharides improve learning and memory impairment.Dec 11, 2022

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Pubmed Data : Int J Biol Macromol. 2022 Dec 12. Epub 2022 Dec 12. PMID: 36521708

Article Published Date : Dec 11, 2022

Study Type : Animal Study

Additional Links

Substances : Cordyceps Militaris

Diseases : Fatigue: Excercise-Induced

Therapeutic Actions : Exercise

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

Additional Keywords : Polysaccharides

[+]

Pubmed Data : Gen Comp Endocrinol. 2015 Sep 8. Epub 2015 Sep 8. PMID: 26361869

Article Published Date : Sep 07, 2015

Deguelin ameliorates diabetic neuropathy by decreasing oxidative stress and plasma glucose levels.Dec 31, 2017

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Pubmed Data : Foods. 2020 Aug 1 ;9(8). Epub 2020 Aug 1. PMID: 32752184

Article Published Date : Jul 31, 2020

Study Type : Animal Study

Additional Links

Substances : Jujube

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cytoprotective, Heme oxygenase-1 up-regulation, Nrf2 activation

Additional Keywords : Plant Extracts

Problem Substances : Benzo(a)pyrene

[+]

dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood. Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(6):e0127244. Epub 2015 Jun 24. PMID: 26107664

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Broccoli Sprouts, Sulforaphane

Diseases : Cognitive Decline/Dysfunction, Neurologic Disorders, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation

Additional Keywords : Plant Extracts

[+]

Dietary luteolin protects against mercuric chloride induced renal injury.Nov 08, 2017

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Pubmed Data : J Inorg Biochem. 2017 Nov 9 ;179:24-31. Epub 2017 Nov 9. PMID: 29156292

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Pubmed Data : Immunopharmacol Immunotoxicol. 2022 Jul 11:1-10. Epub 2022 Jul 11. PMID: 35815581

Article Published Date : Jul 10, 2022

Study Type : Animal Study

Additional Links

Substances : Echinacea

Diseases : Osteoarthritis

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Osteoprotective

[+]

Echinacoside improves cognitive impairment by inhibiting Aβ deposition.Jun 03, 2022

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Pubmed Data : Mol Neurobiol. 2022 Jun 4. Epub 2022 Jun 4. PMID: 35665898

Article Published Date : Jun 03, 2022

Study Type : Animal Study

Additional Links

Substances : Echinacea

Diseases : Alzheimer's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Neuroprotective Agents, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Ecklonia cava ethanol extract has potential therapeutic effects for the alleviation of periodontal disease.May 21, 2019

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Pubmed Data : Nutrients. 2019 May 22 ;11(5). Epub 2019 May 22. PMID: 31121899

Article Published Date : May 21, 2019

Study Type : Animal Study

Additional Links

Substances : Phlorotannins, Seaweed: Brown

Diseases : Periodontitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation

Additional Keywords : Plant Extracts

[+]

Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.Nov 30, 2019

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Pubmed Data : J Bioenerg Biomembr. 2019 Dec ;51(6):393-402. Epub 2019 Nov 25. PMID: 31768722

Article Published Date : Nov 30, 2019

Study Type : Animal Study

Additional Links

Substances : Hydrogen Water

Diseases : Myocardial Ischemia

Pharmacological Actions : Antioxidants, Cardioprotective, Heme oxygenase-1 up-regulation,

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Consumption of anthocyanin-rich beverages affects Nrf2 and Nrf2-dependent gene transcription in peripheral lymphocytes and DNA integrity of healthy volunteers Nov 30, 2020

A functional beverage of mangosteen, aloe vera, green tea, and multivitamins enhances plasma antioxidant capacity in healthy adults.Dec 31, 2014

Astaxanthin treatment has been shown to increase both serum TAC levels and activation of the Nrf2 axis in PCOS patients' GCs.Mar 02, 2022

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status.Mar 31, 2019

Broccoli sprout extract represents an attractive therapeutic candidate for K14-associated epidermolysis bullosa simplex.Feb 28, 2017

Effect of a sulforaphane supplement on muscle soreness and damage induced by eccentric exercise.Jan 11, 2021

L-carnosine protects against oxaliplatin-induced peripheral neuropathy in colorectal cancer patients.Feb 14, 2019

Nrf2 regulates downstream genes by targeting miR-29b in severe asthma and the role of grape seed proanthocyanidin extract.Nov 30, 2022

Ozone therapy is a potential therapeutic alternative for Multiple sclerosis patients.Sep 14, 2017

Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS model.Jan 29, 2023

Short term curcumin intervention ablates diabetic kidney disease progress with activating Nrf2 anti-oxidative system and anti-inflammatory efficacies in patients with T2DM.May 31, 2015

Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke.Nov 19, 2022

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

The data support the strategy of flavonoid supplementation to mitigate post-exercise oxidative stress in endurance athletes.Nov 20, 2019

These result shows that pantothenic acid rich diet can protect bone loss from estrogen deficiency.Dec 31, 2018

Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression in human endothelial cells.Jan 31, 2016

Apigenin and Luteolin significantly activate the PI3K/Nrf2/ARE system, and this activation may be responsible for their anti-inflammatory effects.Apr 21, 2015

Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway.Jan 17, 2020

Caffeic acid phenethyl ester inhibits cell proliferation and up-regulates the antioxidant levels in HSC-T6 cells.Feb 20, 2017

Chokeberry extract may protect endothelial progenitor cells against angiotensin II-induced dysfunction.Dec 14, 2015

Fennel is a potential botanical agent for the treatment of skin damage induced by UV irradiation.Nov 14, 2016

Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.Jan 20, 2018

Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes.Feb 29, 2020

N-acetylcysteine attenuates PM2.5-induced apoptosis by ROS-mediated Nrf2 pathway in human embryonic stem cells.Feb 19, 2019

Pathogenesis and anti-proliferation mechanisms of crocin in human gastric carcinoma cells.Dec 31, 2019

Polyphenol antioxidant treatment may provide an adjunctive action to alleviate pulmonary vascular remodeling.Dec 31, 2016

Protective effects of delphinidin against H2O2-induced oxidative injuries in human retinal pigment epithelial cells.Aug 29, 2019

Punicalagin protects human retinal pigment epithelium cells from ultraviolet radiation-induced oxidative damage.Jun 01, 2020

Sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes.Dec 12, 2016

Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.Jan 01, 2018

Sulforaphane protects against oxidative stress in culture of adult cardiomyocytes.Aug 01, 2018

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

The protective effect of sulforaphane against oxidative stress.Oct 31, 2021

Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honey.Oct 30, 2022

Andrographolide alleviated blood-brain barrier disruption, neuronal apoptosis, and oxidative stress in subarachnoid hemorrhage.Mar 18, 2022

Baicalin improved hepatic injury of NASH by regulating NRF2/HO-1/NRLP3 pathway.Nov 04, 2022

Ginsenoside Rc modulates SIRT6-NRF2 interaction to alleviate alcoholic liver disease. Nov 08, 2022

Melatonin attenuates bisphenol A-induced colon injury.Jan 31, 2023

Multi-target effects of ß-caryophyllene and carnosic acid at the crossroads of mitochondrial dysfunction and neurodegeneration.Jun 17, 2022

Natural compound glycyrrhetinic acid protects against doxorubicin-induced cardiotoxicity.Sep 03, 2022

Piperine attenuates cigarette smoke-induced oxidative stress, lung inflammation, and epithelial-mesenchymal transition.Nov 24, 2022

Protective effects of Lycium barbarum L. berry extracts against oxidative stress-induced damage of the retina of aging mouse and ARPE-19 cells.Dec 12, 2022

Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride-induced liver damage.Dec 31, 2021

Tanshinone IIA regulates Keap1/Nrf2 signal pathway by activating sestrin2 to restrain pulmonary fibrosis.Oct 28, 2022

Baicalin protects LPS-induced blood-brain barrier damage and activates Nrf2-mediated antioxidant stress pathway Jun 30, 2021

Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide.Sep 30, 2016

Ellagic acid protects dopamine neurons from rotenone-induced neurotoxicity via activation of Nrf2 signalling Jul 11, 2020

Myricetin ameliorates sepsis-associated acute lung injury in a murine sepsis model.May 26, 2020

Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis Feb 22, 2022

The dual roles of ginsenosides in improving the anti-tumor efficiency of cyclophosphamide in mammary carcinoma mice. Aug 23, 2020

The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study Mar 25, 2020

The results suggested that the protective effects of Loganin on AKI during sepsis might be mediated by AKT and Nrf2/HO-1 pathway.Dec 31, 2020

18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression.Aug 08, 2021

2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy.Dec 31, 2017

6-gingerol alleviates ferroptosis and inflammation of diabetic cardiomyopathy.Dec 31, 2021

6-Shogaol can alleviate allergic dermatitis-like skin lesions.Oct 31, 2016

7,8-Dihydroxyflavone alleviated the high-fat diet and alcohol-induced memory impairment: behavioral, biochemical and molecular evidence.May 31, 2020

A flavonoids rich bitter orange extract could ameliorate ethanol induced liver injury in mice. Sep 30, 2015

A lipid peroxidation product of DHA exerts cardioprotective effects by activating endothelial Nrf2.Jan 01, 2013

A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits.Oct 31, 2018

A novel acidic polysaccharide from the residue of Panax notoginseng and its hepatoprotective effect on alcoholic liver damage in mice.Feb 05, 2020

A phenolics rich extract of ginger had protective effects against Aflatoxin B1-induced oxidative stress and hepatotoxicity.May 01, 2017

A polyphenol-rich extract from grape and blueberry have a potential benefit on working memory.Dec 31, 2016

A. esculentus flowers protects against transient cerebral ischemia-reperfusion injury.Dec 31, 2017

Açai berry mitigates Parkinson's disease progression showing dopaminergic neuroprotection.Sep 30, 2022

Açaí seed extract (ASE) rich in proanthocyanidins improves cardiovascular remodeling.Jan 04, 2022

Acetyl-11-keto-β-boswellic acid ameliorates cognitive deficits and reduces amyloid-β levels.Mar 31, 2020

Acetyl-11-keto-β-boswellic acid improves clinical symptoms through modulation of Nrf2 and NF-κB pathways.Mar 16, 2022

Acteoside protects against 6-OHDA-induced dopaminergic neuron damage.Aug 31, 2018

Acteoside reduces HMGB1 release and may be beneficial for the treatment of sepsis.Mar 31, 2013

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.Dec 31, 2017

Nrf2 activation

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1403 Abstracts with Nrf2 activation Research