Nrf2 activation

Name	AC	CK
Sulforaphane	96	196
Flavonoids	96	168
Ginsenosides	50	80
Astaxanthin	42	77
Curcumin	41	69
Astragaloside	37	56
Luteolin	30	55
Broccoli Sprouts	9	47
EGCG (Epigallocatechin gallate)	23	39
Pterostilbene	27	39
Berberine	25	38
Hesperidin	15	35
Quercetin	24	35
Naringenin	23	34
Lycopene	22	33
Polyphenols	14	33
Grape Seed Extract	11	29
Melatonin	18	29
Crocin	15	28
Thymoquinone	18	28
Isothiocyanates	12	27
Paeoniflorin	17	27
Apigenin	12	26
Fisetin	16	26
Fucoxanthin	17	26
Licorice	17	26
Resveratrol	18	25
Tanshinone IIA	17	25
Sinomenine	11	24
Ginkgo biloba	14	23
Isoliquiritigenin	12	23
Ellagic Acid	13	22
Icariin	12	22
Myricetin	13	22
Salvia miltiorrhiza	14	22
Andrographolide	11	21
Ferulic acid	12	21
Puerarin	13	21
Aloe Vera	6	20
Vitamin B-5 (Pantothenic Acid)	2	20
Xanthohumol	11	19
Carnosic Acid	10	18
Gastrodin	12	18
Mangiferin	12	18
Moringa oleifera	11	18
Punicalagin	11	18
Chlorogenic Acid	11	17
Fucoidan	11	17
Dandelion	11	16
Formononetin	10	16
acetyl-11-keto-beta-boswellic acid	8	16
Allicin	9	15
Emodin	9	15
Genistein	10	15
Goji	10	15
Rosemaric Acid	9	15
Alpha-Lipoic Acid	9	14
Asiatic Acid	8	14
Biochanin A	8	14
Chrysin	8	14
Coenzyme Q10	8	14
Elderberry	4	14
Green Tea	3	14
Honokiol	9	14
Lotus	9	14
Piceatannol	9	14
Urolithin A	8	14
Cinnamaldehyde	8	13
Cocoa	3	13
Echinacea	7	13
Eriodictyol	9	13
Ginseng	6	13
Hydrogen Water	7	13
Paeonol	7	13
Panax Notoginseng	8	13
Rutin	7	13
Safflower	7	13
Wogonin	8	13
Anthocyanins	9	12
Geraniol	7	12
Mangosteen	2	12
Royal Jelly	6	12
Caffeic acid phenethyl ester	5	11
Carnosine	2	11
Citrus Triterpenoids	5	11
Crocetin	6	11
NAC (N-acetyl-L-cysteine)	4	11
Bilberry	1	10
Bixin	6	10
Catechin	1	10
Ginseng (Korean)	6	10
Grape	6	10
Lactoferrin	5	10
Peony	7	10
Riboflavin (Vitamin B-2)	1	10
Sesamin	4	10
Cardamonin	6	9
Carotenoids	7	9
Celastrol	5	9
Chicoric Acid	5	9
Chokeberry	3	9
Elecampane	5	9
Garlic: Aged	3	9
Gingerol	6	9
Lactobacillus plantarum	5	9
Leonurine	5	9
Lutein	5	9
Organosulfur Compounds	5	9
Phloretin	6	9
Piperine	5	9
Procyanidin B2	7	9
Seaweed: Brown	7	9
Sesamol	6	9
6-Shogaol	6	8
Beta-Caryophyllene	4	8
Blueberry	5	8
Indole-3-Carbinol	5	8
Ligustrazine	4	8
P-Coumaric Acid	5	8
Rosmarinic acid	4	8
Silibinin	5	8
Syringic Acid	4	8
Ursolic Acid	4	8
Vitamin C	6	8
Zinc	5	8
18β-Glycyrrhetinic Acid	3	7
Andrographis	3	7
Betulinic acid	4	7
Blue Honeysuckle	4	7
Delphinidin	2	7
Frankincense	4	7
Ginger	4	7
Gotu Kola	5	7
Hops	4	7
Lion's Mane (Hericium Erinaceus)	5	7
Pomegranate	4	7
Sea buckthorn	4	7
Selenium	4	7
Tangeretin	5	7
Theaflavins	4	7
Thymol	4	7
Vitexins	5	7
Apple	4	6
Carbon 60	3	6
Carnosol	3	6
Chaga Mushroom (Inonotus obliquus)	3	6
Citrus naringin	5	6
Cordyceps Militaris	3	6
Garlic	4	6
Hawthorn	3	6
Hydrogen: Molecular	3	6
Hydroxytyrosol	4	6
Lupeol	3	6
Magnolol	4	6
Nobiletin	4	6
Phlorotannins	4	6
Pomegranate Peel	3	6
Rose	5	6
Saikosaponin	4	6
Turmeric	4	6
Vanillic Acid	3	6
Acai	3	5
Bisdemethoxycurcumin	3	5
Cyanidin 3-glucoside	3	5
Diosmetin	4	5
Dogwood	3	5
Fennel	1	5
Fermented Foods and Beverages	3	5
Gallic Acid	3	5
Genipin	3	5
Glycyrrhizin	3	5
Hemp Seed	4	5
Honeysuckle	3	5
Kaempferol	5	5
Krill	3	5
Maqui	1	5
Okra	3	5
Olive Oil	3	5
Oridonin	3	5
Parthenolide	3	5
Patchouli	3	5
Perillaldehyde	3	5
Poria cocos	3	5
Red Sage	3	5
Scopoletin	3	5
Tetrahydrocurcumin	3	5
Verbascoside	3	5
Apocynin	3	4
Bee Venom	2	4
Benzyl isothiocyanate	2	4
Black Tea	2	4
Carvacrol	3	4
Cinnamon	2	4
DHA (Docosahexaenoic Acid)	2	4
Dates	2	4
Lactobacillus fermentum	2	4
Lactobacillus rhamnosus GG	2	4
Lemongrass	2	4
Lignans	3	4
Medicinal Mushrooms	2	4
Mulberry	2	4
Myrrh	2	4
Nattokinase	2	4
Nicotinamide	2	4
Nicotinamide Mononucleotide	2	4
Omega-3 Fatty Acids	2	4
Phenethyl isothiocyanate	3	4
Proanthocyanidins	2	4
Radish	3	4
Rooibos	2	4
Rosemary	3	4
Schisandra	2	4
Shikonin	3	4
Silymarin	3	4
Skullcap: Chinese	2	4
Strawberry	3	4
Sweet Potato: Purple	3	4
Vitamin E	3	4
Zeaxanthin	2	4
Zerumbone	3	4
Alpha Linolenic Acid	3	3
Babchi	2	3
Bacopa	2	3
Baicalein	2	3
Bamboo	2	3
Berbamine	2	3
Black Pepper	2	3
Broccoli	2	3
Butterbur	2	3
Caffeic Acid	2	3
Cannabidiol	3	3
Cashew	2	3
Citrus Peel	2	3
Coffee	3	3
Ginseng (American)	2	3
Honey	2	3
Hyaluronic Acid	1	3
Hydrangea	2	3
Isothiocyanate	2	3
Jujube	2	3
Kiwifruit	2	3
Magnolia	2	3
Mango	2	3
Manuka Honey	1	3
Oligosaccharides	2	3
Soursop	3	3
Vitamin D	2	3
Xanthones	2	3
Achiote	1	2
Almond	1	2
Alpha Ketoglutarate	1	2
Apple Polyphenols	2	2
Artemisia asiatica	1	2
Artesunate	1	2
Ashwagandha	1	2
Avenanthramides	2	2
Banaba	1	2
Bee Propolis	1	2
Beet	1	2
Bentonite	1	2
Beta Sitosterol	2	2
Betaine	1	2
Betanin	1	2
Betanins	1	2
Bifidobacterium animalis	1	2
Bitter Melon	1	2
Bitter Orange	1	2
Buckwheat	1	2
Burdock	2	2
Cafestol	2	2
Capsaicin	1	2
Chia	1	2
Chives	1	2
Chlorella (Algae)	1	2
Chlorophyllin	1	2
Citicoline	1	2
Citral	1	2
Corn Silk	1	2
Cranberry	1	2
Cryptoxanthin	1	2
Cucurbitacin B	2	2
Cucurbitacin E	1	2
Cyanidin	2	2
Cysteine (see N-Acetylcysteine)	1	2
Deguelin	1	2
Diallyl sulfide	1	2
Dibenzoylmethane (DBM)	1	2
Diosmin	1	2
Docosahexaenoic acid (DHA)	1	2
Eicosapentaenoic acid (EPA)	1	2
Eucalyptus	1	2
Garcinia kola	1	2
Geum japonicum	1	2
Ginseng (Siberian)	1	2
Glycyrrhiza uralensis	1	2
Grapefruit	1	2
Guava	1	2
Guduchi	1	2
Herb Bennet	1	2
Huperzine	1	2
Isoflavones	1	2
Kahweol	2	2
Lactobacillus probiotics	1	2
Lactobacillus reuteri	1	2
Lactobacillus salivarius	1	2
Lauric acid	1	2
Lavender	1	2
Lavender: Essential Oil	1	2
Lemon Balm	1	2
Loquat Leaves	1	2
Maitake Mushroom	1	2
Modified Rice Bran (MGN-3)	1	2
Myrtenol	1	2
Neem	2	2
Niacin	1	2
Nicotinamide adenine dinucleotide (NADH)	1	2
Nigella sativa (aka Black Seed)	1	2
Nordihydroguaiaretic acid (NDGA)	1	2
Nutmeg	1	2
Oats	2	2
Oleocanthal	2	2
Oleuropein	2	2
Olive leaf extract	1	2
Oolong tea	1	2
Orange: Mandarin	1	2
Oyster Mushroom	1	2
Phellinus Linteus	2	2
Prickly Pear Cactus	1	2
Probiotics	1	2
Propolis: Brazillian	1	2
Prunella vulgaris	1	2
Pycnogenol (Pine Bark)	1	2
Raspberry	1	2
Raspberry ketone	1	2
Reishi Mushroom	2	2
Saffron	1	2
Safranal	1	2
Sandalwood	1	2
Seaweed	1	2
Sesame Seeds	1	2
Shiitake Mushroom	1	2
Stevia	1	2
Stilbenes	1	2
Syrian rue	1	2
Terminalia chebula	2	2
Tomatidine	1	2
Triphala	1	2
Turmerones	1	2
Vinpocetine	1	2
Virgin Coconut Oil	1	2
Vitamin E: Gamma-Tocopherol	1	2
Vitamin E: alpha tocopherol	2	2
Walnut	2	2
White Tea	1	2
Yeast	1	2
Yellow Tea	1	2
Zataria multiflora	1	2
beta-Carotene	2	2
Adlay	1	1
Amygdalin	1	1
Amygdalin (laetrile)	1	1
Astragalus	1	1
Barley	1	1
Berries: All	1	1
Bioflavonoids	1	1
Black Currant	1	1
Cabbage	1	1
Caffeine	1	1
Camu Camu	1	1
Cannabis	1	1
Chamomile	1	1
Chrysanthemum Indicum	1	1
Clove	1	1
Cruciferous Vegetables	1	1
Curcuma Longa	1	1
Curcuminoids	1	1
Curcumol	1	1
Epicatechin	1	1
Glutathione	1	1
Gold (nanoparticles)	1	1
Graviola	1	1
Haritaki (Terminalia chebula)	1	1
Hibiscus	1	1
Hirudin (from Medicinal Leaches)	1	1
Kimchi	1	1
Kudzu	1	1
Lemon Peel	1	1
Maple	1	1
Mugwort	1	1
Mung Bean	1	1
Noni	1	1
Nuts: All	1	1
Palmitoylethanolamide	1	1
Papaya: Fermented	1	1
Phyllanthus emblica	1	1
Pine Cone	1	1
Plantago	1	1
Purslane	1	1
Red Clover	1	1
Rhubarb	1	1
Rock-rose	1	1
Salvia divinorum	1	1
Silver (nanoparticles)	1	1
Star Anise (Illicium anisatum)	1	1
Tauroursodeoxycholic acid	1	1
Tocotrienol: Delta	1	1
Tomato	1	1
Tripterygium wilfordii	1	1
Vitamin E: Gamma-tocotrienol	1	1
Water: Deuterium Depleted	1	1
White Button Mushroom	1	1

[+]

Consumption of anthocyanin-rich beverages affects Nrf2 and Nrf2-dependent gene transcription in peripheral lymphocytes and DNA integrity of healthy volunteers Nov 30, 2020

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Pubmed Data : BMC Chem. 2020 Dec ;14(1):39. Epub 2020 May 29. PMID: 32514500

Article Published Date : Nov 30, 2020

Study Type : Human Study

Additional Links

Substances : Bilberry

Diseases : DNA damage

Pharmacological Actions : Antioxidants, Genoprotective, Nrf2 activation

[+]

A functional beverage of mangosteen, aloe vera, green tea, and multivitamins enhances plasma antioxidant capacity in healthy adults.Dec 31, 2014

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Ginkgolide C slows the progression of osteoarthritis.Dec 31, 2021

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Pubmed Data : Front Pharmacol. 2022 ;13:1027553. Epub 2022 Oct 28. PMID: 36386227

Article Published Date : Dec 31, 2021

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginkgo biloba

Diseases : Osteoarthritis

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis.Sep 30, 2019

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Pubmed Data : Int Immunopharmacol. 2019 Oct ;75:105819. Epub 2019 Aug 14. PMID: 31421546

Sinomenine ameliorates IL-1β-induced intervertebral disc degeneration.Dec 31, 2022

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Pubmed Data : Int Immunopharmacol. 2021 Jul ;96:107725. Epub 2021 May 28. PMID: 34162131

Article Published Date : Jun 30, 2021

Study Type : Animal Study

Additional Links

Substances : Flavonoids

Diseases : Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Neuroprotective Agents, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Effects of Oridonin on growth performance and oxidative stress in broilers challenged with lipopolysaccharide.Sep 30, 2016

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Pubmed Data : PLoS One. 2024 ;19(7):e0305358. Epub 2024 Jul 15. PMID: 39008492

Article Published Date : Dec 31, 2023

Study Type : Animal Study

Additional Links

Substances : 6-Shogaol

Diseases : Huntington Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

[+]

A lipid peroxidation product of DHA exerts cardioprotective effects by activating endothelial Nrf2.Jan 01, 2013

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Pubmed Data : PLoS One. 2013 ;8(7):e69415. Epub 2013 Jul 23. PMID: 23936010

Article Published Date : Jan 01, 2013

Study Type : Animal Study

Additional Links

Substances : DHA (Docosahexaenoic Acid), Omega-3 Fatty Acids

Pharmacological Actions : Antioxidant Effects, Antioxidants, Cardioprotective, Nrf2 activation

[+]

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Pubmed Data : Mol Neurobiol. 2022 Oct ;59(10):6519-6533. Epub 2022 Aug 15. PMID: 35970975

Article Published Date : Sep 30, 2022

Study Type : Animal Study

Additional Links

Substances : Acai

Diseases : Neurodegenerative Diseases, Parkinson's Disease

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Neuroprotective Agents, Nrf2 activation

[+]

Açaí seed extract (ASE) rich in proanthocyanidins improves cardiovascular remodeling.Jan 04, 2022

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Pubmed Data : Chem Biol Interact. 2022 Jan 5 ;351:109721. Epub 2021 Oct 27. PMID: 34715092

Acteoside protects against 6-OHDA-induced dopaminergic neuron damage.Aug 31, 2018

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Pubmed Data : Food Chem Toxicol. 2018 Sep ;119:6-13. Epub 2018 Jun 12. PMID: 29906474

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Verbascoside

Diseases : Parkinson's Disease

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation

[+]

Acteoside reduces HMGB1 release and may be beneficial for the treatment of sepsis.Mar 31, 2013

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Pubmed Data : Eur J Pharmacol. 2020 Mar 2:173052. Epub 2020 Mar 2. PMID: 32135124

Article Published Date : Mar 01, 2020

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Allicin

Diseases : Diabetic Complications

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Nrf2 activation

[+]

Allicin ameliorates sepsis-induced acute kidney injury.Sep 04, 2023

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Pubmed Data : Biol Trace Elem Res. 2017 Mar ;176(1):192-200. Epub 2016 Aug 25. PMID: 27561292

Article Published Date : Feb 28, 2017

Pubmed Data : Int Immunopharmacol. 2022 Jan ;102:108382. Epub 2021 Nov 28. PMID: 34848155

Pubmed Data : Phytomedicine. 2023 Aug ;117:154903. Epub 2023 May 29. PMID: 37301185

Article Published Date : Jul 31, 2023

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Liver Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Nrf2 activation

[+]

Andrographolide alleviates paraquat-induced acute lung injury.Dec 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Iran J Basic Med Sci. 2023 ;26(6):653-661. PMID: 37275765

Article Published Date : Dec 31, 2022

Study Type : Animal Study

Additional Links

Substances : Andrographolide

Diseases : Lung Injury: Acute, Pesticide Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Paraquat

[+]

Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway.Jun 19, 2017

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Pubmed Data : Food Funct. 2021 Dec 13 ;12(24):12381-12394. Epub 2021 Dec 13. PMID: 34825683

Article Published Date : Dec 12, 2021

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

[+]

Astaxanthin ameliorated acetaminophen-induced liver injury.Sep 11, 2022

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Pubmed Data : ACS Appl Mater Interfaces. 2022 Sep 12. Epub 2022 Sep 12. PMID: 36094079

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Pubmed Data : Curr Res Transl Med. 2021 Jan 18 ;69(2):103271. Epub 2021 Jan 18. PMID: 33476935

Article Published Date : Jan 17, 2021

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Stroke

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Astaxanthin attenuates cigarette smoking-induced oxidative stress and inflammation in a sirtuin 1-dependent manner.Feb 28, 2023

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Pubmed Data : Ecotoxicol Environ Saf. 2024 Jan 13 ;271:115960. Epub 2024 Jan 13. PMID: 38219622

Article Published Date : Jan 12, 2024

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Developmental Disorder: Children

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

Problem Substances : Flame Retardants

Adverse Pharmacological Actions : Neurotoxic

[+]

Astaxanthin can reduce oxidative stress and promote antioxidant capacity and mitochondrial biogenesis during strenuous HIIT exercise.Mar 31, 2023

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Pubmed Data : Eur J Nutr. 2023 Apr ;62(3):1453-1466. Epub 2023 Jan 17. PMID: 36650315

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Pubmed Data : Can J Physiol Pharmacol. 2023 Sep 8. Epub 2023 Sep 8. PMID: 37683291

Article Published Date : Sep 07, 2023

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Drug Toxicity: Methotrexate, Kidney Damage: Drug-Induced

Pharmacological Actions : Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective

[+]

Astaxanthin promotes Nrf2/ARE signalling to alleviate renal fibronectin and collagen IV accumulation in diabetic rats.Dec 31, 2017

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Pubmed Data : J Diabetes Res. 2018 ;2018:6730315. Epub 2018 Mar 21. PMID: 29744366

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Diabetic Nephropathy

Pharmacological Actions : Antioxidants, Nrf2 activation, Renoprotective

[+]

Astaxanthin promotes Nrf2/ARE signalling to inhibit high glucose induced renal fibrosis in GMCs.Apr 04, 2018

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Pubmed Data : Mar Drugs. 2019 Nov 28 ;17(12). Epub 2019 Nov 28. PMID: 31795292

Article Published Date : Nov 27, 2019

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Chronic Obstructive Pulmonary Disease, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation

[+]

Astaxanthin treatment induces maturation and functional change of myeloid-derived suppressor cells in tumor-bearing mice.Apr 22, 2020

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Pubmed Data : Antioxidants (Basel). 2020 Apr 23 ;9(4). Epub 2020 Apr 23. PMID: 32340271

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Pubmed Data : Molecules. 2018 Aug 14 ;23(8). Epub 2018 Aug 14. PMID: 30110942

Article Published Date : Aug 13, 2018

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Acetaminophen (Tylenol) Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Acetaminophen, Paracetamol

[+]

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2019 Oct ;75:105651. Epub 2019 Aug 8. PMID: 31401385

Article Published Date : Sep 30, 2019

Study Type : Animal Study

Additional Links

Substances : Astragaloside

Diseases : Brain Inflammation , Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Nrf2 activation

[+]

Click here to read the entire abstract

Pubmed Data : Respir Physiol Neurobiol. 2021 10 ;292:103707. Epub 2021 Jun 1. PMID: 34087492

Article Published Date : Jan 09, 2021

Study Type : Animal Study

Additional Links

Substances : Babchi

Diseases : Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents, Nrf2 activation

[+]

Banaba has cardioprotective effects and may prevent myocardial stress by suppressing apoptosis through up-regulation of myocardial antioxidant levels.Dec 31, 2014

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Pubmed Data : Cardiovasc Toxicol. 2015 Jan ;15(1):10-22. PMID: 24853613

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Pubmed Data : Brain Res Bull. 2025 Mar ;222:111221. Epub 2025 Jan 22. PMID: 39855313

Article Published Date : Feb 28, 2025

Study Type : Animal Study

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Substances : Bisdemethoxycurcumin

Diseases : Brain Injury: Traumatic, Oxidative Stress

Pharmacological Actions : Antioxidants, Neuroprotective Agents, Nrf2 activation

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Bixin attenuates carbon tetrachloride induced oxidative stress, inflammation and fibrosis in kidney.Dec 31, 2020

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Pubmed Data : Int Immunopharmacol. 2021 Jan ;90:107117. Epub 2020 Nov 6. PMID: 33162346

Article Published Date : Dec 31, 2020

Study Type : Animal Study

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Substances : Bixin

Diseases : Kidney Damage: Chemically-Induced, Kidney Fibrosis

Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Heme oxygenase-1 up-regulation, Nrf2 activation, Renoprotective, Superoxide Dismutase Up-regulation

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Bixin attenuates high-fat diet-caused liver steatosis and inflammatory injury.Dec 31, 2020

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Pubmed Data : Environ Toxicol Pharmacol. 2017 Sep ;54:80-92. Epub 2017 Jun 28. PMID: 28704754

Article Published Date : Aug 31, 2017

Study Type : Animal Study, In Vitro Study

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Substances : Caffeic acid phenethyl ester

Diseases : Cadmium Poisoning , Diabetic Nephropathy, Kidney Damage: Chemically-Induced

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Nrf2 activation, Renoprotective

Problem Substances : Cadmium

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Capsaicin prevents contrast-associated acute kidney injury.Dec 31, 2021

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Pubmed Data : Biomedicines. 2023 Mar 9 ;11(3). Epub 2023 Mar 9. PMID: 36979808

Article Published Date : Mar 08, 2023

Study Type : Animal Study

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Substances : Carnosic Acid

Diseases : Gastric Ulcer

Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation

Problem Substances : Indomethacin

[+]

Carnosic acid attenuates cadmium induced nephrotoxicity.Nov 17, 2019

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Pubmed Data : Molecules. 2019 Nov 18 ;24(22). Epub 2019 Nov 18. PMID: 31752142

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Pubmed Data : Korean J Physiol Pharmacol. 2016 Jan ;20(1):15-23. Epub 2015 Dec 31. PMID: 26807019

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Pubmed Data : Eur Rev Med Pharmacol Sci. 2022 Dec ;26(23):8738-8755. PMID: 36524493

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Pubmed Data : J Gerontol A Biol Sci Med Sci. 2022 Mar 12. Epub 2022 Mar 12. PMID: 35279029

Article Published Date : Mar 11, 2022

Study Type : Animal Study

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Substances : Chlorogenic Acid

Diseases : Aging

Pharmacological Actions : Antioxidants, Nrf2 activation

Additional Keywords : Gene Expression Regulation

[+]

Chlorogenic acid ameliorates endothelial dysfunction in diabetes.Dec 31, 2020

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Pubmed Data : Cancer Prev Res (Phila). 2015 May ;8(5):444-54. Epub 2015 Feb 23. PMID: 25712056

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Cinnamaldehyde, Cinnamon

Diseases : Colon Cancer: Prevention

Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Chemopreventive, Nrf2 activation

[+]

Cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress.Dec 31, 2016

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Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:1583098. Epub 2017 Mar 15. PMID: 28396714

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Cinnamon

Diseases : High Fat Diet, Hyperlipidemia, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Hypolipidemic, Nrf2 activation

Additional Keywords : Plant Extracts

[+]

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Pubmed Data : Microcirculation. 2020 Jul 22:e12651. Epub 2020 Jul 22. PMID: 32697403

Article Published Date : Jul 21, 2020

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Pre-Eclampsia

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Nrf2 activation

Additional Keywords : Risk Reduction

[+]

Coenzyme Q10 has a coloprotective effect against experimentally induced ulcerative colitis.Jan 02, 2017

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Pubmed Data : Inflammopharmacology. 2017 Jan 3. Epub 2017 Jan 3. PMID: 28050757

Article Published Date : Jan 02, 2017

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10

Diseases : Ulcerative Colitis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Catalase Up-Regulation, Glutathione Upregulation , Heme oxygenase-1 up-regulation, Malondialdehyde Down-regulation, Nrf2 activation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response

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View the Evidence: 1794 Abstracts with Nrf2 activation Research

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Consumption of anthocyanin-rich beverages affects Nrf2 and Nrf2-dependent gene transcription in peripheral lymphocytes and DNA integrity of healthy volunteers Nov 30, 2020

A functional beverage of mangosteen, aloe vera, green tea, and multivitamins enhances plasma antioxidant capacity in healthy adults.Dec 31, 2014

Acupressure bladder meridian alleviates anxiety disorder via HMGB1.Jan 24, 2024

Astaxanthin treatment has been shown to increase both serum TAC levels and activation of the Nrf2 axis in PCOS patients' GCs.Mar 02, 2022

Benefit of glucosyl Hesperidin in patients with primary biliary cholangitis.Dec 01, 2022

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status.Mar 31, 2019

Broccoli sprout extract represents an attractive therapeutic candidate for K14-associated epidermolysis bullosa simplex.Feb 28, 2017

Cocoa flavanols in peripheral artery disease.Jan 31, 2024

Effect of a sulforaphane supplement on muscle soreness and damage induced by eccentric exercise.Jan 11, 2021

Elderberry extract improves molecular markers of endothelial dysfunction linked to atherosclerosis.Jun 30, 2023

L-carnosine protects against oxaliplatin-induced peripheral neuropathy in colorectal cancer patients.Feb 14, 2019

Nrf2 regulates downstream genes by targeting miR-29b in severe asthma and the role of grape seed proanthocyanidin extract.Nov 30, 2022

Ozone therapy is a potential therapeutic alternative for Multiple sclerosis patients.Sep 14, 2017

Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS model.Jan 29, 2023

Short term curcumin intervention ablates diabetic kidney disease progress with activating Nrf2 anti-oxidative system and anti-inflammatory efficacies in patients with T2DM.May 31, 2015

Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke.Nov 19, 2022

Sulforaphane treatment resulted in a significant reduction in specific airway resistance and also increased small airway luminal area.Dec 31, 2014

Sulforaphane’s capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway, and may protect against environmental and endogenous risk factors in autism spectrum disorders.Oct 27, 2014

The data support the strategy of flavonoid supplementation to mitigate post-exercise oxidative stress in endurance athletes.Nov 20, 2019

These result shows that pantothenic acid rich diet can protect bone loss from estrogen deficiency.Dec 31, 2018

Aged garlic extract enhances heme oxygenase-1 and glutamate-cysteine ligase modifier subunit expression in human endothelial cells.Jan 31, 2016

Apigenin and Luteolin significantly activate the PI3K/Nrf2/ARE system, and this activation may be responsible for their anti-inflammatory effects.Apr 21, 2015

Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway.Jan 17, 2020

Caffeic acid phenethyl ester inhibits cell proliferation and up-regulates the antioxidant levels in HSC-T6 cells.Feb 20, 2017

Chokeberry extract may protect endothelial progenitor cells against angiotensin II-induced dysfunction.Dec 14, 2015

Fennel is a potential botanical agent for the treatment of skin damage induced by UV irradiation.Nov 14, 2016

Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.Jan 20, 2018

Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes.Feb 29, 2020

Maqui berry and ginseng extracts reduce cigarette smoke-induced cell injury.Dec 13, 2022

N-acetylcysteine attenuates PM2.5-induced apoptosis by ROS-mediated Nrf2 pathway in human embryonic stem cells.Feb 19, 2019

Pathogenesis and anti-proliferation mechanisms of crocin in human gastric carcinoma cells.Dec 31, 2019

Polyphenol antioxidant treatment may provide an adjunctive action to alleviate pulmonary vascular remodeling.Dec 31, 2016

Protective effects of delphinidin against H2O2-induced oxidative injuries in human retinal pigment epithelial cells.Aug 29, 2019

Punicalagin protects human retinal pigment epithelium cells from ultraviolet radiation-induced oxidative damage.Jun 01, 2020

Sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes.Dec 12, 2016

Sulforaphane delays fibroblast aging in vitro by decreasing glycolysis and reducing oxidative stress.Jan 01, 2018

Sulforaphane protects against oxidative stress in culture of adult cardiomyocytes.Aug 01, 2018

Sulforaphane regulates xenobiotic metabolism phase II and III enzymes differently in colorectal cancer and untransformed epithelial colon cells.Oct 31, 2016

The protective effect of sulforaphane against oxidative stress.Oct 31, 2021

Acetyl-11-keto-β-boswellic acid may serve as a promising treatment for age-related cataract progression.Dec 31, 2021

Amyloid β-but not Tau-induced neurotoxicity is suppressed by Manuka honey.Oct 30, 2022

Andrographolide alleviated blood-brain barrier disruption, neuronal apoptosis, and oxidative stress in subarachnoid hemorrhage.Mar 18, 2022

Andrographolide inhibits static mechanical pressure-induced intervertebral disc degeneration.Dec 31, 2022

Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye.Apr 30, 2023

Baicalin improved hepatic injury of NASH by regulating NRF2/HO-1/NRLP3 pathway.Nov 04, 2022

Carnosol alleviates sepsis-induced pulmonary endothelial barrier dysfunction.Feb 26, 2024

Celastrol can ameliorate neonatal hypoxic-ischemic brain injury.May 19, 2024

Diallyl disulfide blocks cigarette carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.Nov 21, 2023

Emodin attenuates diabetic kidney disease by inhibiting ferroptosis via upregulating Nrf2 expression.Aug 06, 2023

Epicatechin gallate blocked cellular foam formation in atherosclerosis.Mar 05, 2023

Farrerol ameliorates acetaminophen-induced hepatotoxicity.Dec 31, 2018

Ferulic acid protects HepG2 cells and mouse liver from iron-induced damage.Aug 31, 2023

Ginkgolide C slows the progression of osteoarthritis.Dec 31, 2021

Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis.Sep 30, 2019

Ginsenoside Rc modulates SIRT6-NRF2 interaction to alleviate alcoholic liver disease. Nov 08, 2022

Hesperetin ameliorates spinal cord injury by inhibiting NLRP3 inflammasome.Apr 30, 2023

Hyaluronic acid-curcumin nanoparticles for preventing the progression of experimental autoimmune uveitis.Feb 06, 2025

Hyperoside ameliorates renal tubular oxidative damage and calcium oxalate deposition.Dec 31, 2022

Limonin inhibits IL-1 β-induced inflammation and catabolism in chondrocytes and ameliorates osteoarthritis.Dec 31, 2020

Melatonin attenuates bisphenol A-induced colon injury.Jan 31, 2023

Molecular hydrogen protects mice against polymicrobial sepsis.Aug 31, 2015

Multi-target effects of ß-caryophyllene and carnosic acid at the crossroads of mitochondrial dysfunction and neurodegeneration.Jun 17, 2022

Natural compound glycyrrhetinic acid protects against doxorubicin-induced cardiotoxicity.Sep 03, 2022

Nephroprotective potential of syringic acid in experimental diabetic nephropathy.Dec 31, 2022

Nrf2 activation by neferine mitigates microglial neuroinflammation after subarachnoid hemorrhage.Mar 29, 2024

Pharmacological activation of the Nrf2 pathway by Taxifolin remodels articular cartilage microenvironment for the therapy of osteoarthritis.Aug 31, 2023

Piperine attenuates cigarette smoke-induced oxidative stress, lung inflammation, and epithelial-mesenchymal transition.Nov 24, 2022

Protective effect of crocin on peroxidation-induced oxidative stress and apoptosis in IPEC-J2 cells.Mar 11, 2024

Protective effects of Lycium barbarum L. berry extracts against oxidative stress-induced damage of the retina of aging mouse and ARPE-19 cells.Dec 12, 2022

Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride-induced liver damage.Dec 31, 2021

Sinomenine ameliorates cardiac hypertrophy by activating Nrf2/ARE signaling pathway.Nov 30, 2021

Sinomenine ameliorates IL-1β-induced intervertebral disc degeneration.Dec 31, 2022

Nrf2 activation

View the Evidence:
1794 Abstracts with Nrf2 activation Research