P21 Activation

Name	AC	CK
Curcumin	6	15
Polyphenols	2	11
Thymoquinone	4	8
Antrodia camphorata	2	7
Apigenin	2	6
Curcumin: Degradiation byproducts	1	5
Ginger	1	5
Magnolol	1	5
Tetrahydrocurcumin	1	5
Zerumbone	1	5
EGCG (Epigallocatechin gallate)	2	4
Luteolin	3	4
Pterostilbene	2	4
Resveratrol	3	4
Chaga Mushroom (Inonotus obliquus)	2	3
Prickly Pear Cactus	2	3
Salvia miltiorrhiza	2	3
Shikonin	2	3
Urolithin A	3	3
Anthocyanins	2	2
Berberine	2	2
Crocetin	2	2
Cucurbitacin B	2	2
Curcumol	1	2
Damnacanthal	2	2
Ellagic Acid	2	2
Flavonoids	2	2
Genistein	2	2
Litchi	1	2
Nexrutine (Phellodendrom)	2	2
Nobiletin	2	2
Oleanolic acid	1	2
Oleuropein	2	2
Oyster Mushroom	2	2
Phellinus Linteus	1	2
Quercetin	1	2
Reishi Mushroom	1	2
Rosmarinic acid	1	2
Safranal	1	2
Shallot	1	2
Tanshinone IIA	2	2
Tocotrienol: Delta	1	2
Vitamin C	2	2
Vitamin E	1	2
Xanthohumol	2	2
Allicin	1	1
Andrographis	1	1
Antineoplastons	1	1
Apple Polyphenols	1	1
Apples	1	1
Asiatic Acid	1	1
Berbamine	1	1
Bergamot orange	1	1
Berries: All	1	1
Beta-Elemene	1	1
Bitter Apple	1	1
Blackberry	1	1
Caffeic Acid	1	1
Capsaicin	1	1
Cardamonin	1	1
Chickpea	1	1
Chrysin	1	1
Cordyceps Militaris	1	1
Cranberry	1	1
Cruciferous Vegetables	1	1
Cryptoxanthin	1	1
Diosgenin	1	1
Diosmin	1	1
Fermented Foods and Beverages	1	1
Fisetin	1	1
Flavan-3-ols	1	1
Gallic Acid	1	1
Ginkgo biloba	1	1
Ginseng	1	1
Ginseng (Korean)	1	1
Ginsenosides	1	1
Goji	1	1
Grape	1	1
Green Tea	1	1
Harmine	1	1
Hesperidin	1	1
Homeopathic Medicine: All	1	1
Hydrangea	1	1
Indole-3-Carbinol	1	1
Isoflavones	1	1
Isoliquiritigenin	1	1
Kimchi	1	1
Lactobacillus rhamnosus GG	1	1
Lactoferrin	1	1
Lotus	1	1
Lycopene	1	1
Melatonin	1	1
Mistletoe	1	1
Mulberry	1	1
Mushrooms: All	1	1
Nordihydroguaiaretic acid (NDGA)	1	1
Orange: Mandarin	1	1
Patchouli	1	1
Perilla	1	1
Phyllanthus amarus	1	1
Piperlongumine	1	1
Pomegranate Peel	1	1
Propolis: Brazillian	1	1
Psychedelics:All	1	1
Rhubarb	1	1
Rose	1	1
Schisandra	1	1
Sinomenine	1	1
Stevia	1	1
Stilbenes	1	1
Sulforaphane	1	1
Ursolic Acid	1	1
Verbascoside	1	1
Walnut	1	1
Wheat Grass	1	1
Wogonin	1	1
Zataria multiflora	1	1
Zyflamend	1	1
beta-Carotene	1	1

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Zerumbone was able to induce apoptosis of pancreatic carcinoma cell lines Jan 01, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:936030. Epub 2012 Jan 29. PMID: 22454691

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Pubmed Data : Sci Rep. 2017 Jan 30 ;7:41656. Epub 2017 Jan 30. PMID: 28134352

Article Published Date : Jan 29, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Litchi

Diseases : Prostate Cancer

Pharmacological Actions : Anti-metastatic, Apoptotic, Cell cycle arrest, P21 Activation

Additional Keywords : Anti-metastatic, Apoptotic, Cell cycle arrest, Litchi, P21 Activation, Plant Extracts, prostate cancer

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CARI III exerted anti-cancer activity that is comparable to doxorubicin against melanoma in vivo, as well as in vitro.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Molecules. 2015 ;20(8):13927-40. Epub 2015 Jul 31. PMID: 26263965

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Cordyceps Militaris

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Plant Extracts

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A methoxyflavanone from Perilla frutescens induces cellular senescence in A549 human lung adenocarcinoma cells.Aug 17, 2022

Click here to read the entire abstract

Pubmed Data : Biol Pharm Bull. 2022 Aug 18. Epub 2022 Aug 18. PMID: 35979561

Annurca apple polyphenol extract strongly inhibits the proliferation of MCF-7 cells by inducing G2/M cell cycle arrest and apoptosis.Aug 31, 2017

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Pubmed Data : Int J Oncol. 2017 Sep ;51(3):939-948. Epub 2017 Jul 31. PMID: 28766690

Article Published Date : Aug 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Apple Polyphenols

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation

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Antitumorigenic effect of damnacanthal on melanoma cell viability through p53 and NF-κB/caspase-3 signaling pathways.Oct 31, 2018

Pubmed Data : Mol Med Rep. 2016 Jun 13. Epub 2016 Jun 13. PMID: 27314273

Article Published Date : Jun 12, 2016

Study Type : In Vitro Study

Additional Links

Substances : Anthocyanins, Berries: All

Diseases : Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, P21 Activation

Additional Keywords : Dose Response

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Beta-elemene has antitumor activity against both platinum-sensitive and resistant ovarian cancer cells.Jul 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Cranberry flavonols and PACs possess cytotoxic properties against ovarian cancer cells. Apr 30, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Oncol. 2015 May ;46(5):1924-34. Epub 2015 Mar 17. PMID: 25776829

Article Published Date : Apr 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Cranberry, Flavan-3-ols

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemosensitizer, Cytotoxic, Epidermal growth factor receptor (EGFR) inhibitor, P21 Activation

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

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Crocetin combined with cisplatin exerts a synergistic anticancer effect by up-regulating the p53/p21 pathway.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Int J Oncol. 2015 Oct 21. Epub 2015 Oct 21. PMID: 26498137

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Pubmed Data : Oncol Lett. 2014 May ;7(5):1479-1484. Epub 2014 Feb 20. PMID: 24765160

Article Published Date : Apr 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Damnacanthal

Diseases : Breast Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, P21 Activation, Tumor Suppressor Protein p53 Upregulation

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Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells.Jan 31, 2015

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Pubmed Data : Integr Cancer Ther. 2012 Apr 13. Epub 2012 Apr 13. PMID: 22505596

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : EXCLI J. 2018 ;17:531-543. Epub 2018 Jun 6. PMID: 30034317

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Hydrangea

Diseases : Bladder Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-9 (MMP-9) inhibitor, P21 Activation

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Indole-3-carbinol induced cell growth inhibition by G1 cell cycle arrest and triggered apoptosis in a dose and time dependent manner.Apr 30, 2015

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Pubmed Data : Tumour Biol. 2015 May ;36(5):3919-30. Epub 2015 Jan 15. PMID: 25589462

Nobiletin could overcome multidrug resistance in human ovarian cancer cells.Apr 06, 2018

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Pubmed Data : Biomed Pharmacother. 2018 Apr 7 ;103:29-37. Epub 2018 Apr 7. PMID: 29635125

Article Published Date : Apr 06, 2018

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Cancers: Multi-Drug Resistant, Ovarian Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Chemotherapeutic, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Selective Antiproliferation

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Nobiletin had antiproliferative and apoptosis inducing actions in triple negative breast cancer cells.Mar 31, 2014

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Pubmed Data : Anticancer Res. 2014 Apr ;34(4):1785-92. PMID: 24692711

Article Published Date : Mar 31, 2014

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Antineoplastic Agents, Antioxidants, Antiproliferative , Apoptotic, Cell cycle arrest, Chemopreventive, P21 Activation

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Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up-regulating p21.Dec 31, 2010

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Chem Biol Interact. 2009 Sep 14 ;181(1):138-43. Epub 2009 May 18. PMID: 19450571

Article Published Date : Sep 13, 2009

Study Type : In Vitro Study

Additional Links

Substances : Ginseng

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , P21 Activation

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Click here to read the entire abstract

Pubmed Data : Cancer Sci. 2010 Feb;101(2):488-93. Epub 2009 Oct 27. PMID: 20028382

Article Published Date : Feb 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol, Stilbenes

Diseases : Bladder Cancer

Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Cyclin D1 Down-Regulation, Cyclin-Dependent Kinase 4 Down-Regulation, P21 Activation, Phosphorylated Rb Down-Regulation

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Resveratrol nanoparticles induce apoptosis in oral cancer stem cells.Jun 03, 2024

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Pubmed Data : Med Oncol. 2024 Jun 4 ;41(7):167. Epub 2024 Jun 4. PMID: 38831079

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Pubmed Data : Int J Mol Sci. 2022 Jan 20 ;23(3). Epub 2022 Jan 20. PMID: 35163058

Article Published Date : Jan 19, 2022

Study Type : In Vitro Study

Additional Links

Substances : Salvia miltiorrhiza

Diseases : Melanoma

Pharmacological Actions : Anti-metastatic, Antiproliferative , Matrix metalloproteinase-2 (MMP-2) inhibitor, P21 Activation, Tumor Suppressor Protein p53 Upregulation

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Schizandrin B has potent anti-tumor activity and may be a promising traditional Chinese medicine for human lung carcinoma.Dec 31, 2014

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Pubmed Data : Pathol Res Pract. 2020 Aug ;216(8):152995. Epub 2020 Apr 25. PMID: 32402536

Article Published Date : Jul 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Harmine

Diseases : Gastric Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Matrix metalloproteinase-2 (MMP-2) inhibitor, P21 Activation, Survivin Down-Regulation

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The molecular mechanisms of Tanshinone IIA on the apoptosis and arrest of human esophageal carcinoma cells.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2014 ;2014:582730. Epub 2014 Apr 15. PMID: 24829906

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Tanshinone IIA

Diseases : Esophageal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, P21 Activation, Tumor Suppressor Protein p53 Upregulation

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The phytochemical indicaxanthin synergistically enhances cisplatin-induced apoptosis in HeLa cells.Jul 01, 2020

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomolecules. 2020 Jul 2 ;10(7). Epub 2020 Jul 2. PMID: 32630700

Article Published Date : Jul 01, 2020

Study Type : In Vitro Study

Additional Links

Substances : Prickly Pear Cactus

Diseases : Cervical Cancer

Pharmacological Actions : Chemosensitizer, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Chemotherapeutic Synergy: Cisplatin

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These findings indicate that fisetin is a promising antitumor agent against renal cell carcinoma.Aug 20, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

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Vitamin C supplementation had anticancer properties in ovarian cancer cells.Feb 02, 2020

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Pubmed Data : Int J Vitam Nutr Res. 2020 Feb 3:1-11. Epub 2020 Feb 3. PMID: 32008465

Article Published Date : Feb 02, 2020

Study Type : In Vitro Study

Additional Links

Substances : Vitamin C

Diseases : Ovarian Cancer

Pharmacological Actions : Antiproliferative , Glucose transporter-1 (GLUT1) expression down-regulation, P21 Activation, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Tumor Microenvironment

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Wogonin inhibits the proliferation of myelodysplastic syndrome cells.Oct 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

View the Evidence: 144 Abstracts with P21 Activation Research

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Curcuminoids could be coadjuvants that might help fight breast cancer upon regular consumption.May 31, 2021

Resistance exercise-induced hormonal response promotes satellite cell proliferation in untrained men but not in women.Jul 31, 2019

An ethanolic extract of T. camphoratus treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin.Dec 31, 2014

Magnolol induced cell cycle arrest and promoted apoptosis in gallbladder carcinoma cells by regulating the p53 signaling pathway.Sep 30, 2015

Tetrahydrocurcumin exhibited significant cell growth inhibition by inducing MCF-7 cells to undergo mitochondrial apoptosis and G2/M arrest.Apr 30, 2014

The present study results indicated that human bladder cancer T-24 cells are highly sensitive to growth inhibition by apigenin.Dec 31, 2014

Thymoquinone promotes pancreatic cancer cell death and reduction of tumor size.Dec 31, 2015

Zerumbone was able to induce apoptosis of pancreatic carcinoma cell lines Jan 01, 2012

A compound from Allium hirtifolium could inhibit growth of MCF-7 and MDA-MB-231 cells through cell cycle arrest and apoptosis induction.Aug 31, 2017

A methanol extract of Salvia miltiorrhiza Bunge induced apoptosis in non-small cell lung cancer.Mar 21, 2017

An extract of Litchi seed has potential for development into a safe and potent alternative therapy for prostate cancer patients.Jan 29, 2017

CARI III exerted anti-cancer activity that is comparable to doxorubicin against melanoma in vivo, as well as in vitro.Dec 31, 2013

Eastern prickly pear extract may be a promising candidate for treating human cervical carcinoma.Dec 31, 2014

EGCG enhanced the anti-tumor effect of doxorubicine in bladder cancer.Dec 31, 2019

Induction of p21 by EGCG could provide clinically useful normalization of salivary glands by promoting differentiation and reducing PCNA levels.Jan 31, 2014

Inulin enhanced rifaximin-inhibited colon cancer pulmonary metastasis by flora-regulated bile acid pathway.Jul 31, 2024

Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced solid ehrlich carcinomaAug 31, 2019

Oleanolic acid inhibits the growth of DU145, MCF-7, and U87 cancer cells.May 28, 2018

Pterostilbene inhibits lung squamous cell carcinoma growth in vitro and in vivo by inducing S phase arrest and apoptosis.Jul 31, 2019

Pterostilbene is a potential chemoprevention agent for lung squamous cell carcinoma.Jul 20, 2021

Quercetin has a protective effect on atherosclerosis via enhancement of autophagy.Sep 30, 2019

Resveratrol attenuated pulmonary arterial remodeling, decreased pulmonary arterial pressure, and upregulated SIRT1 and p21 expression.Dec 31, 2014

Rosmarinic acid reverses non-small cell lung cancer cisplatin resistance by activating the MAPK signaling pathway.Jan 26, 2020

Safrana l prevents prostate cancer recurrence.Dec 31, 2019

Shikonin inhibits cancer through P21 upregulation and apoptosis induction.Dec 31, 2019

Synergistic anti-tumorigenic effect of diosmetin in combination with 5-fluorouracil on human colon cancer xenografts.Sep 06, 2024

These results indicate the potential of curcumol in the prevention of colon cancer carcinogenesis.Jan 09, 2018

Tocotrienols are potent antitumor agents capable of inducing apoptosis and inhibiting angiogenesis under both hypoxic and normoxic conditions.Jul 31, 2015

MDM2 as a target for ellagic acid‑mediated suppression of prostate cancer cells in vitro.Aug 31, 2020

Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells.Jul 31, 2020

Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells.Feb 20, 2014

3,3'-Diindolylmethane inhibits histone deacetylase activity in prostate cancer cells.Sep 14, 2012

A carotenoid extract was effective at inhibiting growth of HT-29 colon cancer cells.Mar 06, 2017

A crude extract of Rheum palmatum has anticancer effects in vitro against Osteosarcoma cells.Feb 16, 2015

A lyophilized grape extract comparable to putative dietary doses induced important morphology changes, migration inhibition, downregulation of undifferentiated stem/stem-like cells markers and EMT.Mar 31, 2015

A methanolic extract of C. militaris at the concentration significantly inhibited cell proliferation and induced apoptosis of NCI-H460 cells.Dec 31, 2014

A methoxyflavanone from Perilla frutescens induces cellular senescence in A549 human lung adenocarcinoma cells.Aug 17, 2022

A water extract of Rosa hybrida has the potential to act as a novel agent for the prevention and treatment of vascular diseases.Feb 24, 2016

Acteoside inhibits human promyelocytic HL-60 leukemia cell proliferation.Aug 31, 2007

Activated ERK/FOXM1 pathway by low-power laser irradiation inhibits UVB-induced senescence through down-regulating p21 expression.Dec 31, 2013

An analogue of anandamide Met-F-AEA could have significance in providing a basis for the management of thyroid carcinomas.Mar 31, 2010

Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer.Feb 29, 2012

Annurca apple polyphenol extract strongly inhibits the proliferation of MCF-7 cells by inducing G2/M cell cycle arrest and apoptosis.Aug 31, 2017

Antitumorigenic effect of damnacanthal on melanoma cell viability through p53 and NF-κB/caspase-3 signaling pathways.Oct 31, 2018

Apigenin could be used to potentially increase the effects of cisplatin by targeting cancer stem cells subset in prostate cancer.Mar 31, 2017

Autophagy plays an important role in the inhibition of cancer cell proliferation by Nexrutine.Dec 31, 2014

Baicalin lipid nanocapsules for treatment of glioma.Oct 31, 2022

Berbamine may be a promising candidate to be used in combination with gemcitabine for pancreatic cancer treatment.Apr 30, 2014

Berberine could be a potential adjunct for the treatment of gastrointestinal cancers.Aug 19, 2018

Berberine inhibits esophageal cancer cell growth by promoting cell cycle arrest at G2 phase and the apoptotic process.Apr 13, 2017

Bergamot juice could reduce the growth of human hepatocellular carcinoma HepG2 cells.Jan 03, 2016

Berry anthocyanins reduce proliferation of human colorectal carcinoma cells.Jun 12, 2016

Beta-elemene has antitumor activity against both platinum-sensitive and resistant ovarian cancer cells.Jul 31, 2012

Blackberry Ellagitannins showed anti-cancer activity by arresting the cell cycle and inducing apoptosis on HT-29 human colon cancer cells.May 12, 2015

Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells.Dec 31, 2016

Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway.Sep 30, 2015

Cardamonin induces G2/M arrest and apoptosis via activation of the JNK-FOXO3a pathway in breast cancer cells.Aug 07, 2019

Chloroform extract of Citrus unshiu Markovich peel induces apoptosis and inhibits stemness in HeLa human cervical cancer cells.Dec 31, 2020

Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells.Apr 30, 2022

Combination of tanshinone IIA and cisplatin inhibits esophageal cancer.Dec 31, 2019

Combination treatment with dihydrotanshinone I and irradiation enhances apoptotic effects in human cervical cancer.Mar 31, 2012

Condurango 30C appeared to trigger key epigenetic events of gene modulation in effectively combating cancer cells, which the placebo was unable to do.Nov 30, 2013

Cranberry flavonols and PACs possess cytotoxic properties against ovarian cancer cells. Apr 30, 2015

Crocetin combined with cisplatin exerts a synergistic anticancer effect by up-regulating the p53/p21 pathway.Dec 31, 2016

Cucurbitacin B may exert a therapeutic effect on paclitaxel-resistant human ovarian cancer.Jun 30, 2017

Curcumin demonstrates promising therapeutic potential as a new treatment modality for head and neck cancer management.Oct 26, 2015

Curcumin enhances the effects of cisplatin by targeting the cancer stem like cell subpopulation in NSCLC.Nov 01, 2015

Curcumin exerts anti-proliferative effects in both parental and chemoresistant NSCLC cells.Oct 20, 2015

Cyclin D1 is an important determinant of the therapeutic efficiency of Sulforaphane in A549 cells.May 31, 2016

Cytotoxic activity of caffeic acid and gallic acid against MCF-7 human breast cancer cells.Oct 31, 2019

Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells.Apr 30, 2014

Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells.Jan 31, 2015

P21 Activation

View the Evidence:
144 Abstracts with P21 Activation Research