Phase II Detoxification Enzyme Inducer

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52 Substances Researched for Phase II Detoxification Enzyme Inducer
NameACCKFocus
Sulforaphane1744Locked
Broccoli211Locked
Broccoli Sprouts35Locked
Flavonoids24Locked
Coffee23Locked
Garlic33Locked
Resveratrol23Locked
Acacia catechu12Locked
Black Tea12Locked
Brussel sprouts12Locked
Carvacrol12Locked
Catechin 12Locked
Citrus Triterpenoids12Locked
Curcumin12Locked
Fenugreek12Locked
Flaxseed12Locked
Henna12Locked
Licorice12Locked
Moringa oleifera12Locked
Neem12Locked
Olive leaf extract12Locked
Polyphenols12Locked
Prickly Pear Cactus12Locked
Stilbenes12Locked
Sweet Potato12Locked
Tea12Locked
Thyme12Locked
Alpha-Lipoic Acid11Locked
Anthocyanins11Locked
Berries: All11Locked
Biochanin A11Locked
Chlorogenic Acid11Locked
Cinnamaldehyde11Locked
Daisy11Locked
Elecampane11Locked
Genistein11Locked
Ginger11Locked
Grape11Locked
Green Leafy Vegetables11Locked
Hemp Seed11Locked
Holy Basil11Locked
Kaempferol11Locked
Kahweol11Locked
Lycopene11Locked
Onion11Locked
Phloretin11Locked
Pterostilbene11Locked
Quercetin11Locked
Saffron11Locked
Schisandra11Locked
Sprouts11Locked
Thymoquinone11Locked
Related Topics

Phase II Detoxification Enzyme Inducer is a Sub of the following Topic

View the Evidence:
55 Abstracts with Phase II Detoxification Enzyme Inducer Research

[+]

Oral sulforaphane safely and effectively induces mucosal Phase II enzyme expression in the upper airway of human subjects. Mar 01, 2009

Pubmed Data : Clin Immunol. 2009 Mar;130(3):244-51. Epub 2008 Nov 22. PMID: 19028145
Article Published Date : Mar 01, 2009
Study Type : Human Study
Additional Links
Substances : Sulforaphane
Diseases : COPD, Cystic Fibrosis, Glutathione Deficiency , Lung Diseases, Pulmonary Fibrosis, Respiratory Diseases
Pharmacological Actions : Antioxidants, Glutathione Upregulation , Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates
[+]

Sulforaphane-containing broccoli sprout extracts induce a cytoprotective phase 2 response in mouse and human skin.Apr 01, 2007

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):847-51. PMID: 17416783
Article Published Date : Apr 01, 2007
Study Type : Human Study
Additional Links
Substances : Broccoli, Sulforaphane
Diseases : Skin Diseases
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Sulforaphane protected the injury of vascular endothelial cell by LPC by enhancing anti-oxidative capabilities mediated by Nrf-2 translocation.May 25, 2015

Pubmed Data : Food Funct. 2015 May 26. Epub 2015 May 26. PMID: 26008201
Article Published Date : May 25, 2015
Study Type : Human In Vitro
Additional Links
Substances : Sulforaphane
Diseases : Endothelial Damage, Endothelial Dysfunction
Pharmacological Actions : Antioxidants, Phase II Detoxification Enzyme Inducer, Superoxide Dismutase Up-regulation
[+]

"Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog."Nov 29, 2012

Pubmed Data : Toxicol Appl Pharmacol. 2012 Nov 30. Epub 2012 Nov 30. PMID: 23201461
Article Published Date : Nov 29, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Chemical Weapon Agent Injury , Skin Cancer: Prevention
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

Acacia catechu extract affords hepato-protection against DMBA in rats through modulation of phase I, II and anti-oxidative enzymes.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2014 ;9(2):e90083. Epub 2014 Feb 27. PMID: 24587216
Article Published Date : Dec 31, 2013
Study Type : Animal Study
Additional Links
Substances : Acacia catechu
Diseases : Chemically-Induced Liver Damage, Oxidative Stress
Pharmacological Actions : Hepatoprotective, Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Broccoli and its phytochemical sulforaphane activate detoxification enzymes that may protect against polycyclic aromatic hydrocarbon induced toxicity. Mar 01, 2009

Pubmed Data : Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID: 19144376
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Oxidative Stress, Petroleum Exposure And Toxicity, Polycyclic aromatic hydrocarbon (PAH) toxicity
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

Broccoli sprout extract containing sulforaphane attentuated alcohol-induced oxidative stress and endoplasmic reticulum stress through restoration of antioxidant enzyme function in mice.Jun 06, 2018

Pubmed Data : J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID: 29730925
Article Published Date : Jun 06, 2018
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts, Sulforaphane
Diseases : Alcohol Toxicity , Oxidative Stress
Pharmacological Actions : Malondialdehyde Down-regulation, Nrf2 activation, Phase II Detoxification Enzyme Inducer, Superoxide Dismutase Up-regulation
Additional Keywords : Plant Extracts
[+]

Broccoli sprout extract protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis.Sep 20, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2015 Sep 21 ;21(35):10091-103. PMID: 26401074
Article Published Date : Sep 20, 2015
Study Type : Animal Study
Additional Links
Substances : Broccoli Sprouts
Diseases : Acetaminophen (Tylenol) Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective, Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer
Additional Keywords : Gene Expression Regulation, Plant Extracts
Problem Substances : Acetaminophen
[+]

Brussel sprouts induce detoxifying enzymes. Aug 01, 2010

Pubmed Data : J Food Sci. 2010 Aug 1;75(6):H190-9. PMID: 20722931
Article Published Date : Aug 01, 2010
Study Type : Animal Study
Additional Links
Substances : Brussel sprouts, Sulforaphane
Diseases : Chemical Exposure, Intoxication
Pharmacological Actions : Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates, Plant Extracts
[+]

Citrus bioactive compounds induce detoxifying enzymes which may have chemopreventive properties. Jan 01, 2010

Pubmed Data : BMC Complement Altern Med. 2010;10:51. Epub 2010 Sep 17. PMID: 20846448
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Citrus Triterpenoids
Diseases : Cancers: All
Pharmacological Actions : Chemopreventive, Phase II Detoxification Enzyme Inducer, Quinone Reductase-Inducer
[+]

Dietary flaxseed supplementation may be an effective chemoprevention strategy for chemically induced lung carcinogenesis.Dec 31, 2017

Pubmed Data : Cancer Prev Res (Phila). 2018 Jan ;11(1):27-37. Epub 2017 Oct 26. PMID: 29074535
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Flaxseed
Diseases : Lung Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antioxidants, Chemopreventive, Phase II Detoxification Enzyme Inducer
[+]

Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in male mice, indicating its protective value against chemical carcinogenesis and toxicity.Jan 01, 2003

Pubmed Data : Pharmacol Toxicol. 2003 Jan;92(1):33-8. PMID: 12710595
Article Published Date : Jan 01, 2003
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Phase II Detoxification Enzyme Inducer
[+]

Fenugreek (Trigonella foenum graecum) seed polyphenols protects the liver from alcohol toxicity. Apr 01, 2007

Pubmed Data : Pharmazie. 2007 Apr;62(4):299-304. PMID: 17484288
Article Published Date : Apr 01, 2007
Study Type : Animal Study
Additional Links
Substances : Fenugreek, Flavonoids, Polyphenols
Diseases : Alcohol Toxicity , Alcoholic Liver Disease
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Green coffee contains compounds which induce glutathione S-transferase and therefore may promote the detoxification of xenobiotics.Mar 31, 1982

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancer Res. 1982 Apr ;42(4):1193-8. PMID: 7059995
Article Published Date : Mar 31, 1982
Study Type : Animal Study
Additional Links
Substances : Coffee
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

Green sweet potato leaves increase Nrf2-mediated antioxidant activity and facilitate benzo[ a]pyrene metabolism in the liver.Jun 30, 2022

Pubmed Data : Food Funct. 2022 Jul 1. Epub 2022 Jul 1. PMID: 35775432
Article Published Date : Jun 30, 2022
Study Type : Animal Study
Additional Links
Substances : Sweet Potato
Diseases : Benzo[a]pyrene-induced Toxicity , Chemically-Induced Liver Damage
Pharmacological Actions : Hepatoprotective, Phase II Detoxification Enzyme Inducer
Problem Substances : Benzo(a)pyrene
[+]

Green tea exhibits cardioprotective properties against myocardial ischemia. Jan 01, 2010

Pubmed Data : Nutr Res. 2010 Jan;30(1):32-9. PMID: 20116658
Article Published Date : Jan 01, 2010
Study Type : Animal Study
Additional Links
Substances : Catechin , Tea
Diseases : Myocardial Ischemia
Pharmacological Actions : Antioxidants, Cardioprotective, Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Henna positively modulates phase I and II enzymes in a mouse model of skin adn forestomach cancer. Mar 01, 2003

Pubmed Data : Mol Cell Biochem. 2003 Mar;245(1-2):11-22. PMID: 12708740
Article Published Date : Mar 01, 2003
Study Type : Animal Study
Additional Links
Substances : Henna
Diseases : Gastric Cancer, Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive, Phase I Detoxification Enzyme Inhibitor, Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic phase-II detoxification enzymes.Feb 01, 2009

Pubmed Data : Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G372-81. Epub 2008 Dec 12. PMID: 19074639
Article Published Date : Feb 01, 2009
Study Type : Animal Study
Additional Links
Substances : Licorice
Diseases : Hepatitis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cholagogues and Choleretics, Phase II Detoxification Enzyme Inducer
[+]

Moringa oleifera leaves induced antioxidant and phase II enzymes in a colitis-associated colon carcinogenesis.May 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Dev Nutr. 2019 Jun ;3(Suppl 1). Epub 2019 Jun 13. PMID: 31224959
Article Published Date : May 31, 2019
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Colitis, Colon Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive, Phase II Detoxification Enzyme Inducer
[+]

Neem extract exhibits chemopreventive effects on chemically-induced buccal pouch cancer in hamsters.Jun 01, 2005

Pubmed Data : J Exp Clin Cancer Res. 2005 Jun;24(2):223-30. PMID: 16110755
Article Published Date : Jun 01, 2005
Study Type : Animal Study
Additional Links
Substances : Neem
Diseases : Oral Cancer
Pharmacological Actions : Anticarcinogenic Agents, Phase II Detoxification Enzyme Inducer
[+]

Olive leaf extract influences liver microsomal detoxifying enzymes in rats orally exposed to 2-amino-l-methyI-6-phenyI-imidazo pyridine.Sep 30, 2022

Pubmed Data : Environ Sci Pollut Res Int. 2022 Oct 1. Epub 2022 Oct 1. PMID: 36181589
Article Published Date : Sep 30, 2022
Study Type : Animal Study
Additional Links
Substances : Olive leaf extract
Diseases : Cancers: All, Oxidative Stress
Pharmacological Actions : Antioxidants, Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer
Problem Substances : Polycyclic aromatic hydrocarbon
[+]

Pretreatment with black tea polyphenols positively modulates xenobiotic-metabolizing enzymes in an experimental oral carcinogenesis model.Jan 01, 2008

Pubmed Data : Oncol Res. 2008;17(2):75-85. PMID: 18543609
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Black Tea, Flavonoids
Diseases : DNA damage, Oral Cancer
Pharmacological Actions : Chemopreventive, Phase II Detoxification Enzyme Inducer
[+]

Resveratrol, a compound found within grapes, prevents chemically-induced breast and skin cancer.Dec 28, 1984

Pubmed Data : Biochem Biophys Res Commun. 1984 Dec 28;125(3):996-1004. PMID: 8985016
Article Published Date : Dec 28, 1984
Study Type : Animal Study
Additional Links
Substances : Resveratrol, Stilbenes
Diseases : Breast Cancer, Inflammation, Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antimutagenic Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase Inhibitors, Hydroperoxidase Inhibitor, Phase II Detoxification Enzyme Inducer
[+]

Sulforaphane potently induces phase 2 enzymes in bladder tissues and should be investigated as a bladder cancer preventive agent.Jan 01, 2006

Pubmed Data : BMC Cancer. 2006;6:62. Epub 2006 Mar 15. PMID: 16539699
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Sulforaphane
Diseases : Bladder Cancer
Pharmacological Actions : Anticarcinogenic Agents, Phase II Detoxification Enzyme Inducer
[+]

These results suggest that O. humifusa exerts chemopreventive effects on chemical carcinogenesis.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Cancer Prev. 2012 ;13(9):4655-60. PMID: 23167397
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Prickly Pear Cactus
Diseases : Lipid Peroxidation, Oxidative Stress, Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Phase II Detoxification Enzyme Inducer, Superoxide Dismutase Up-regulation
Additional Keywords : Phytotherapy
[+]

Thyme and its constituents increase the activities of xenobiotic-metabolizing enzymes in mouse liver.Jan 01, 2005

Pubmed Data : J Med Food. 2005;8(2):184-9. PMID: 16117610
Article Published Date : Jan 01, 2005
Study Type : Animal Study
Additional Links
Substances : Carvacrol, Thyme
Diseases : Xenobiotic Exposures
Pharmacological Actions : Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Anthocyanins may defend against oxidative stress through increasing the expression of detoxifying phase II enzymes.Nov 14, 2007

Pubmed Data : J Agric Food Chem. 2007 Nov 14;55(23):9427-35. Epub 2007 Oct 13. PMID: 17935293
Article Published Date : Nov 14, 2007
Study Type : In Vitro Study
Additional Links
Substances : Anthocyanins
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Apoptotic, Phase II Detoxification Enzyme Inducer
[+]

Berry constituents quercetin, kaempferol, and pterostilbene activated the Nrf2-ARE signaling pathway and exhibited synergistic antioxidative stress activity at appropriate concentrations.Sep 30, 2014

Pubmed Data : Food Chem Toxicol. 2014 Oct ;72:303-11. Epub 2014 Aug 8. PMID: 25111660
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Berries: All, Kaempferol, Pterostilbene, Quercetin
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation, Phase II Detoxification Enzyme Inducer
Additional Keywords : Natural Substance Synergy
[+]

Broccoli sprouts are an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.Sep 16, 1997

Pubmed Data : Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10367-72. PMID: 9294217
Article Published Date : Sep 16, 1997
Study Type : In Vitro Study
Additional Links
Substances : Broccoli, Sprouts, Sulforaphane
Diseases : Breast Cancer
Pharmacological Actions : Anticarcinogenic Agents, Phase II Detoxification Enzyme Inducer
Additional Keywords : Isothiocyanates
[+]

Carpesium abrotanoide, a member of the daisy family, induces phase II detoxification enzymes and programmed cell death in human colorectal cancer cells. Feb 01, 2010

Pubmed Data : J Med Food. 2010 Feb;13(1):39-46. PMID: 20136434
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Daisy
Diseases : Colorectal Cancer
Pharmacological Actions : Apoptotic, Phase II Detoxification Enzyme Inducer
[+]

Cinnamaldehyde enhances detoxification by increasing phase 2 enzyme expression. May 11, 2011

Pubmed Data : J Agric Food Chem. 2011 May 11;59(9):5164-71. Epub 2011 Apr 15. PMID: 21469739
Article Published Date : May 11, 2011
Study Type : In Vitro Study
Additional Links
Substances : Cinnamaldehyde
Diseases : Intoxication
Pharmacological Actions : Glutathione Upregulation , Phase II Detoxification Enzyme Inducer
[+]

Garlic and onion have chemopreventive properties partially due to their ability to induce phase II detoxification enzymes, although those with hemolytic anemia should be cautious with their use. Dec 14, 2005

Pubmed Data : J Agric Food Chem. 2005 Dec 14;53(25):9695-700. PMID: 16332117
Article Published Date : Dec 14, 2005
Study Type : In Vitro Study
Additional Links
Substances : Garlic, Onion
Diseases : Cancers: All, Hemolytic Anemia
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Cautions, Diseases that are Linked
[+]

Garlic contains compounds which induces phase II detoxifying enzymes. Jun 01, 2010

Pubmed Data : Nutr Res. 2010 Jun;30(6):435-40. PMID: 20650352
Article Published Date : Jun 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Garlic
Diseases : Liver Cancer
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Ginger contains the compound zerumbone, which may have chemopreventive activity through activating phase II drug metabolizing enzymes. Aug 13, 2004

Pubmed Data : FEBS Lett. 2004 Aug 13;572(1-3):245-50. PMID: 15304356
Article Published Date : Aug 13, 2004
Study Type : In Vitro Study
Additional Links
Substances : Ginger
Diseases : Cancers: All
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Phase II Detoxification Enzyme Inducer
[+]

Green leaf vegetables protect against oxidant induced cytotoxicity and are inducers of phase II detoxification enzymes. Dec 28, 2005

Pubmed Data : World J Gastroenterol. 2005 Dec 28;11(48):7607-14. PMID: 16437686
Article Published Date : Dec 28, 2005
Study Type : In Vitro Study
Additional Links
Substances : Green Leafy Vegetables
Diseases : Oxidative Stress
Pharmacological Actions : Antioxidants, Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Hemp seed polysaccharides protect intestinal epithelial cells from hydrogen peroxide-induced oxidative stress.Aug 14, 2019

Pubmed Data : Int J Biol Macromol. 2019 Aug 15 ;135:203-211. Epub 2019 May 17. PMID: 31108145
Article Published Date : Aug 14, 2019
Study Type : In Vitro Study
Additional Links
Substances : Hemp Seed
Diseases : Hydrogen Peroxide Induced Toxicity, Oxidative Stress
Pharmacological Actions : Antioxidants, Nrf2 activation, Phase II Detoxification Enzyme Inducer
[+]

Holy basil protects against chemically-induced genotoxicity, oxidative stress, and imbalance in xenobiotic-metabolizing enzymes.Sep 01, 2007

Pubmed Data : J Med Food. 2007 Sep;10(3):495-502. PMID: 17887944
Article Published Date : Sep 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Holy Basil
Diseases : DNA damage, Oxidative Stress
Pharmacological Actions : Antioxidants, Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

In this review, they discuss the biochemical and biological properties of sulforaphane with a particular emphasis on the anticancer properties of the dietary compound.May 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxid Redox Signal. 2015 Jun 1 ;22(16):1382-424. Epub 2014 Dec 19. PMID: 25364882
Article Published Date : May 31, 2015
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive, Histone deacetylase inhibitor, NF-kappaB Inhibitor, Phase II Detoxification Enzyme Inducer
Additional Keywords : Dietary Concentrations, Selective Cytotoxicity
[+]

Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium.Oct 31, 2008

Pubmed Data : Phytother Res. 2008 Nov ;22(11):1500-5. PMID: 18702092
Article Published Date : Oct 31, 2008
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Oxidative Stress
Pharmacological Actions : Detoxifier, Enzyme Activators, Nrf2 activation, Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Phloretin has possible chemopreventive role in which modulating the antioxidant and detoxification enzyme status.Apr 30, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Int. 2014 May ;21(2):179-85. PMID: 25253928
Article Published Date : Apr 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Phloretin
Diseases : Oral Cancer
Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Phase I Detoxification Enzyme Inducer, Phase II Detoxification Enzyme Inducer
[+]

Phytoestrogens-mediated induction of phase II detoxification enzymes may be responsible for their protective effect against estrogen-induced breast cancer. Jan 01, 2005

Pubmed Data : Biochem J. 2005 Jan 1;385(Pt 1):279-87. PMID: 15456407
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A, Genistein, Resveratrol
Diseases : Breast Cancer, DNA damage, Estrogen Dominance
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Estrogen Receptor Beta, Stilbenes
[+]

Procyanidins from wild grape seeds could be used as a potential natural chemopreventive agent.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2012 ;13(1):801-18. Epub 2012 Jan 13. PMID: 22312287
Article Published Date : Dec 31, 2011
Study Type : In Vitro Study
Additional Links
Substances : Grape
Diseases : Liver Cancer
Pharmacological Actions : Antioxidants, Chemopreventive, Nrf2 activation, Phase II Detoxification Enzyme Inducer
Additional Keywords : Proanthocyanidins
[+]

Raw broccoli sprouts juice was shown here to protect against Aβ-induced cytotoxicity and apoptosis. Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2015 ;2015:781938. Epub 2015 Jun 9. PMID: 26180595
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Broccoli Sprouts
Diseases : Alzheimer's Disease, Brain: Oxidative Stress
Pharmacological Actions : Antioxidants, Neuroprotective Agents, NF-E2-Related Factor-2 (Nrf2) Modulator, Nrf2 activation, Phase II Detoxification Enzyme Inducer
Additional Keywords : Vegetable Juice
[+]

Saffron possesses potent anti-tumor properties and represents an efficacious and safe treatment.Mar 31, 2018

Pubmed Data : Phytomedicine. 2018 Apr 1 ;43:21-27. Epub 2018 Mar 19. PMID: 29747750
Article Published Date : Mar 31, 2018
Study Type : Review
Additional Links
Substances : Saffron
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Cell cycle arrest, Phase II Detoxification Enzyme Inducer
[+]

Schisandra chinesis induces phase II detoxification enzymes in liver cancer cells, indicating its potential in the prevention of liver cancer. Oct 01, 2009

Pubmed Data : Planta Med. 2009 Oct;75(12):1314-8. Epub 2009 May 18. PMID: 19452436
Article Published Date : Oct 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Schisandra
Diseases : Liver Cancer
Pharmacological Actions : Chemopreventive, Phase II Detoxification Enzyme Inducer
[+]

Sulforaphane and alpha-lipoic acid upregulate the expression of the phase 2 liver detoxification enzyme glutathione S-transferase.Mar 01, 2010

Pubmed Data : J Nutr Health Aging. 2010 Mar;14(3):219-23. PMID: 20237067
Article Published Date : Mar 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Alpha-Lipoic Acid, Garlic, Sulforaphane
Diseases : Glutathione Deficiency
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts
[+]

Sulforaphane can be used as an effective adjunct for the prevention of renal oxidative insults during ischemia-reperfusion injury.Jun 01, 2008

Pubmed Data : Biochem Pharmacol. 2008 Jun 1;75(11):2214-23. Epub 2008 Mar 4. PMID: 18407246
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Kidney Damage
Pharmacological Actions : Apoptotic, Phase II Detoxification Enzyme Inducer, Renoprotective
[+]

Sulforaphane inhibits diesel exhaust particle induced enhanced igE production in B cells.Mar 01, 2006

Pubmed Data : Appl Microbiol Biotechnol. 2006 Mar;70(2):247-53. Epub 2005 Jun 28. PMID: 16920990
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Allergies, Diesel Exhaust Particle Toxicity , IgE-Mediated Hypersensitivity
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

Sulforaphane may modulate phase II enzymes in such a way as to generate cardioprotection.Jun 24, 2009

Pubmed Data : J Agric Food Chem. 2009 Jun 24;57(12):5615-22. PMID: 19456137
Article Published Date : Jun 24, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Cardiovascular Diseases, Oxidative Stress
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
[+]

Sulforaphane nduces a series of total cellular as well as mitochondrial antioxidants and phase 2 enzymes in rat aortic smooth muscle cells, indicating it may have cardioprotective properties.Jan 01, 2008

Pubmed Data : Cardiovasc Toxicol. 2008;8(3):115-25. Epub 2008 Jul 8. PMID: 18607771
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Aortic Plaques, Oxidative Stress
Pharmacological Actions : Antioxidants, Cardioprotective, Phase II Detoxification Enzyme Inducer
[+]

The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver.Oct 31, 2008

Pubmed Data : Med Hypotheses. 2008 Nov ;71(5):730-6. Epub 2008 Aug 12. PMID: 18701223
Article Published Date : Oct 31, 2008
Study Type : Review
Additional Links
Substances : Chlorogenic Acid, Coffee, Kahweol
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants, Chemopreventive, Nrf2 activation, Phase II Detoxification Enzyme Inducer
[+]

These results provide support for the beneficial use of TQ as a therapeutic and chemopreventive agent against liver cancer.Jun 30, 2015

Pubmed Data : J Nat Med. 2015 Jul ;69(3):313-23. Epub 2015 Mar 22. PMID: 25796541
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Brain Cancer, Cervical Cancer, Colon Cancer, Liver Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, Enzyme Activators, Phase II Detoxification Enzyme Inducer
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This article reviews data on the cancer preventive activities of lycopene and possible mechanisms involved.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cancers (Basel). 2011 ;3(2):2333-57. Epub 2011 May 11. PMID: 24212813
Article Published Date : Dec 31, 2010
Study Type : Review
Additional Links
Substances : Lycopene
Diseases : Lung Cancer, Lung Cancer: Metastatic, Lung Cancer: Prevention
Pharmacological Actions : Anticarcinogenic Agents, Nrf2 activation, Phase II Detoxification Enzyme Inducer
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This review establishes sulforaphane as a safe and non-toxic chemopreventative agent and indicates the need for more research for its use in human cancers as a single agent or as part of combination therapy.Jan 01, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:2905-2913. Epub 2018 Sep 11. PMID: 30254420
Article Published Date : Jan 01, 2018
Study Type : Review
Additional Links
Substances : Sulforaphane
Diseases : Cancers
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Phase II Detoxification Enzyme Inducer
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Isothiocyanates
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This study elucidates the mechanisms behind the neurovascular protective effects of sulforaphane.Aug 23, 2018

Pubmed Data : Sci Rep. 2018 Aug 23 ;8(1):12708. Epub 2018 Aug 23. PMID: 30139948
Article Published Date : Aug 23, 2018
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Pharmacological Actions : Antioxidant Effects, Glucose Uptake Optimization, Phase II Detoxification Enzyme Inducer
Additional Keywords : Broccoli, Broccoli Sprouts, Cruciferous Vegetables, Drug Metabolism, Mitochondria, Mitochondrial Biogenesis

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