PI3K/Akt/signaling suppression

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6 Substances Researched for PI3K/Akt/signaling suppression

Name	AC	CK
Wogonin	1	5
Mangosteen	1	2
Carrot	1	1
Holy Basil	1	1
Melatonin	1	1
Oleuropein	1	1

Research Articles 6
Cumulative Knowledge Score 9
Overall Research Rating GOOD

View the Evidence:
6 Abstracts with PI3K/Akt/signaling suppression Research

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Wogonin decreased the expression of glycolysis-related proteins, glucose uptake and lactate generation in a dose-dependent manner.Jan 31, 2014

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Pubmed Data : Mol Carcinog. 2014 Feb ;53 Suppl 1:E107-18. Epub 2013 Jun 13. PMID: 23761018

Article Published Date : Jan 31, 2014

Study Type : Animal Study, Human In Vitro

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Substances : Wogonin

Diseases : Cancers: Drug Resistant, Cancers: Multi-Drug Resistant, Colon Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Hypoxia-inducible factor-1 (HIF-1) inhibitor, PI3K/Akt/signaling suppression

Additional Keywords : Cancer Glycolysis, Resistance Reversal

[+]

α-mangostin suppressed the proliferation, migration, and invasion of pancreatic cancer cells.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Res Int. 2014 ;2014:546353. Epub 2014 Apr 10. PMID: 24812621

Article Published Date : Dec 31, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Mangosteen

Diseases : Pancreatic Cancer, Pancreatic Cancer: Metastatic

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Cell cycle arrest, PI3K/Akt/signaling suppression

[+]

"Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells."Jul 31, 2012

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Pubmed Data : J Pineal Res. 2012 Aug ;53(1):77-90. Epub 2012 Feb 16. PMID: 22335196

Article Published Date : Jul 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Melatonin

Diseases : Breast Cancer

Pharmacological Actions : Antioxidants, Antiproliferative , Apaf-1/caspase-dependent apoptotic pathway activator, Apoptotic, Cyclooxygenase 2 Inhibitors, p300/NF-κB down-regulation, PI3K/Akt/signaling suppression

[+]

An extract of holy basil significantly inhibited cell adhesion and invasion at nontoxic concentrations.Dec 31, 2013

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2014 ;14:419. Epub 2014 Oct 27. PMID: 25345853

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Holy Basil

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor, PI3K/Akt/signaling suppression, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

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Daucus Carota oil extracts inhibited cell proliferation by inducing cell cycle arrest and apoptosis in HT-29 cells.Jan 18, 2015

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Pubmed Data : J Med Food. 2015 Jan 19. Epub 2015 Jan 19. PMID: 25599142

Article Published Date : Jan 18, 2015

Study Type : In Vitro Study

Additional Links

Substances : Carrot

Diseases : Colon Cancer, Colon Cancer: Prevention

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Caspase-3 Activation, Cell cycle arrest, PI3K/Akt/signaling suppression

Additional Keywords : Plant Extracts

[+]

Oleuropein effectively inhibited cell viability and induced apoptosis in HepG2 human hepatoma cells in a dose‑dependent manner, through activation of the caspase pathway. May 31, 2015

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Pubmed Data : Mol Med Rep. 2015 Jun ;11(6):4617-24. Epub 2015 Jan 28. PMID: 25634350

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Oleuropein

Diseases : Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, PI3K/Akt/signaling suppression

Additional Keywords : Dose Response

Research Articles 6
Cumulative Knowledge Score 9
Overall Research Rating GOOD

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Focus Your Research

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View the Evidence: 6 Abstracts with PI3K/Akt/signaling suppression Research

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Wogonin decreased the expression of glycolysis-related proteins, glucose uptake and lactate generation in a dose-dependent manner.Jan 31, 2014

Click here to read the entire abstract

α-mangostin suppressed the proliferation, migration, and invasion of pancreatic cancer cells.Dec 31, 2013

Click here to read the entire abstract

"Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells."Jul 31, 2012

Click here to read the entire abstract

An extract of holy basil significantly inhibited cell adhesion and invasion at nontoxic concentrations.Dec 31, 2013

Click here to read the entire abstract

Daucus Carota oil extracts inhibited cell proliferation by inducing cell cycle arrest and apoptosis in HT-29 cells.Jan 18, 2015

Click here to read the entire abstract

Oleuropein effectively inhibited cell viability and induced apoptosis in HepG2 human hepatoma cells in a dose‑dependent manner, through activation of the caspase pathway. May 31, 2015

Click here to read the entire abstract

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PI3K/Akt/signaling suppression

View the Evidence:
6 Abstracts with PI3K/Akt/signaling suppression Research