Postaglandin PGE2 downregulation

Name	AC	CK
Ginger	3	13
Turmeric	3	13
Black Pepper	2	11
Pterocarpus marsupium	1	10
Pterostilbene	1	10
Seaweed: Brown	2	7
Astragaloside	1	5
Flavonoids	4	5
Niacinamide	1	5
Resveratrol	1	5
Sesamin	1	5
Hesperidin	2	4
Kaempferol	2	4
Spirulina	2	4
Curcumin	3	3
Fisetin	2	3
Formononetin	2	3
Magnolol	2	3
Paeonol	2	3
Peony	3	3
6-Shogaol	1	2
Asiatic Acid	2	2
Basil	1	2
Bee Venom	1	2
Black Currant	1	2
Black Raspberry	1	2
Bromelain	1	2
Citral	1	2
Crocin	2	2
D-Limonene	1	2
Delphinidin	1	2
Eriodictyol	1	2
Fermented Foods and Beverages	2	2
Fucoxanthin	1	2
Gardenia	1	2
Genipin	1	2
Geraniol	1	2
Ginseng	1	2
Ginsenosides	1	2
Guduchi	1	2
Honeydew (melon)	1	2
Honeysuckle	1	2
Honokiol	1	2
Hops	1	2
Isoliquiritigenin	1	2
Lime	1	2
Phloretin	2	2
Puerarin	1	2
Purslane	1	2
Quercetin	1	2
Royal Jelly	1	2
Tangeretin	1	2
Turmeric: Fermented	1	2
Urolithin A	1	2
Vitamin E	1	2
Apple	1	1
Baicalein	1	1
Banana	1	1
Beta-Caryophyllene	1	1
Biochanin A	1	1
Butterbur	1	1
Caffeoylquinic Acids	1	1
Chia	1	1
Chokeberry	1	1
Chrysanthemum Morifolium	1	1
Citrus Peel	1	1
Cocoa	1	1
Coenzyme Q10	1	1
Coumestrol	1	1
Dandelion	1	1
Emodin	1	1
Genistein	1	1
Glycyrrhizin	1	1
Gotu Kola	1	1
Guava	1	1
Lotus	1	1
Maple Syrup	1	1
Moringa oleifera	1	1
Myricetin	1	1
Nigella sativa (aka Black Seed)	1	1
Nobiletin	1	1
Oleuropein	1	1
Orange: Mandarin	1	1
Oridonin	1	1
P-Coumaric Acid	1	1
Paeoniflorin	1	1
Passion Flower	1	1
Patchouli	1	1
Pine Needle	1	1
Poria cocos	1	1
Red Clover	1	1
Selenium	1	1
Skullcap: Chinese	1	1
Sulforaphane	1	1
Tanshinone IIA	1	1
Thymoquinone	1	1
Wogonin	1	1

[+]

Herbal formulation turmeric extract, black pepper, and ginger versus naproxen for chronic knee osteoarthritis.Jul 31, 2020

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Pubmed Data : Phytother Res. 2020 Aug ;34(8):2067-2073. Epub 2020 Mar 16. PMID: 32180294

Article Published Date : Jul 31, 2020

Study Type : Human Study

Additional Links

Substances : Black Pepper, Ginger, Turmeric

Diseases : Osteoarthritis: Knee

Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation

Additional Keywords : Natural Substances Versus Drugs

[+]

Local ice cryotherapy had beneficial effects in human non-septic knee arthritis.Jul 29, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

[+]

Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.Oct 04, 2022

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Pubmed Data : Int J Biol Macromol. 2022 Oct 5. Epub 2022 Oct 5. PMID: 36208806

Article Published Date : Oct 04, 2022

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fucoidan

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

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Ferulic acid may be a potential therapy for osteoarthritis.Jun 01, 2021

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Hops (H. lupulus) has anti-inflammatory activity in a mouse model of athritis. Jul 16, 1996

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Pubmed Data : Biochem Biophys Res Commun. 1996 Jul 16;224(2):358-61. PMID: 16534727

Article Published Date : Jul 16, 1996

Study Type : Animal Study

Additional Links

Substances : Hops

Diseases : Arthritis, Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

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In vivo anti-inflammatory activity of the peels and pulps of Cucumis melo.Jun 11, 2019

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Pubmed Data : J Ethnopharmacol. 2019 Jun 12 ;237:245-254. Epub 2019 Mar 9. PMID: 30857984

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Pubmed Data : J Ginseng Res. 2021 Jul ;45(4):482-489. Epub 2020 Oct 17. PMID: 34295208

Article Published Date : Jun 30, 2021

Study Type : Animal Study

Additional Links

Substances : Ginseng (Korean)

Diseases : Asthma

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-12 downregulation, Interleukin-4 downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation

[+]

LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.Dec 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

[+]

Protective effect of carotenoid extract from orange-fleshed sweet potato on gastric ulcer.Dec 16, 2021

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Food Funct. 2019 Sep 9. Epub 2019 Sep 9. PMID: 31497826

Article Published Date : Sep 08, 2019

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Urolithin A

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Vitamin E-induced decrease in influenza viral titre is mediated through enhancement of Th1 cytokines.Jul 31, 2000

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : ScientificWorldJournal. 2013 ;2013:434151. Epub 2013 Dec 9. PMID: 24385881

[+]

Glycyrrhizic acid facilitates anti-tumor immunity by attenuating Tregs and MDSCs: An immunotherapeutic approach.Sep 01, 2020

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Pubmed Data : Int Immunopharmacol. 2020 Sep 2 ;88:106932. Epub 2020 Sep 2. PMID: 32890791

Article Published Date : Sep 01, 2020

Study Type : In Vitro Study

Additional Links

Substances : Glycyrrhizin

Diseases : Melanoma

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Postaglandin PGE2 downregulation

[+]

Green, black and rooibos tea inhibit prostaglandin E2 formation in human monocytes.Jan 07, 2022

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Front Pharmacol. 2020 ;11:523962. Epub 2020 Nov 12. PMID: 33343339

Article Published Date : Dec 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Moringa oleifera

Diseases : Prostate Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation

[+]

Nelumbo leaf extracts can ameliorate disease conditions involving chronic inflammation.Jul 31, 2017

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Pubmed Data : Nutr Res Pract. 2017 Aug ;11(4):265-274. Epub 2017 Jul 21. PMID: 28765772

Article Published Date : Jul 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Lotus

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Anti-Inflammatory Agents, Inflammation, Lotus

[+]

New lanostane-type triterpenes with anti-inflammatory activity from the epidermis of Wolfiporia cocos.Mar 28, 2022

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Pubmed Data : J Agric Food Chem. 2022 Mar 29. Epub 2022 Mar 29. PMID: 35347990

Article Published Date : Mar 28, 2022

Study Type : In Vitro Study

Additional Links

Substances : Medicinal Mushrooms

Diseases : Inflammation

[+]

Ocimum basilicum L. seed may be useful as a dietary supplement to enhance fatty acid oxidation.Feb 17, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Published Date : Oct 31, 2020

Study Type : In Vitro Study

Additional Links

Substances : Safflower

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation

[+]

Selenium added to chokeberry juice enhances significantly its anti-inflammatory activity.Jun 13, 2015

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Pubmed Data : Fitoterapia. 2015 Jun 14 ;105:73-82. Epub 2015 Jun 14. PMID: 26079445

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Pubmed Data : Inflammation. 2018 Oct ;41(5):1755-1761. PMID: 29951871

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Dandelion

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

The anti-inflammatory activity of licorice, a widely used Chinese herb.Nov 30, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharm Biol. 2017 Dec ;55(1):5-18. Epub 2016 Sep 21. PMID: 27650551

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View the Evidence: 162 Abstracts with Postaglandin PGE2 downregulation Research

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Herbal formulation turmeric extract, black pepper, and ginger versus naproxen for chronic knee osteoarthritis.Jul 31, 2020

Local ice cryotherapy had beneficial effects in human non-septic knee arthritis.Jul 29, 2019

Photobiomodulation therapy is able to modulate PGE2 levels in patients with chronic non-specific low back pain.Jan 31, 2021

Pterocarpus marsupium extract exhibits anti-inflammatory activity in human subjects. May 01, 2005

Astragaloside potentially serve as a promising and effective therapeutic agent for treating osteoarthritis patients.Jul 31, 2019

Betulinic acid exerts anti-inflammatory activity in human periodontal ligament cells stimulated with lipopolysaccharide or high glucose.May 08, 2022

Marine alga Ecklonia cava extract and dieckol attenuate prostaglandin E2 production in HaCaT keratinocytes exposed to airborne particulate matter.Jun 20, 2019

Niacinamide mitigates SASP-related inflammation induced by environmental stressors in human epidermal keratinocytes and skin.Sep 30, 2020

Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.May 07, 2017

Sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes.Dec 12, 2016

Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.Oct 04, 2022

The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study Mar 25, 2020

6-Shogaol reduces progression of experimental endometriosis.Oct 31, 2018

Activities of Andrographis paniculata tablet on Cox-2 and prostaglandin expression of placental of Plasmodium berghei infection.Dec 31, 2020

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.May 09, 2019

Andrographolide may have therapeutic value in the treatment of stroke.Sep 30, 2010

Anti-colonic inflammation by black raspberries.Jun 29, 2020

Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate.Aug 31, 2021

Antiosteoarthritic effect of morroniside in chondrocyte inflammation and destabilization of medial meniscus-induced mouse model.Mar 14, 2021

Antipyretic effects of citral and possible mechanisms of action. Sep 30, 2017

Astilbin influences the progression of osteoarthritis in rats by down-regulation of PGE-2 expression via the NF-κB pathway.May 31, 2020

Basil may be used as a nutritional supplement or therapeutic drug to protect against aspirin-induced gastric ulcers.Aug 14, 2018

Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in a sciatic nerve ligation model.Jan 10, 2021

C-phycocyanin relieved symptoms associated with cyclophosphamide-induced cystitis.Dec 31, 2018

Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway.Dec 31, 2021

Citrus hystrix leaf extract attenuated diabetic-cataract in STZ-rats.Jun 14, 2020

D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis.Mar 31, 2017

Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis.Jan 31, 2012

Dietary turmeric led to a decrease in DMBA-induced tumor burden and multiplicity in animals. Oct 31, 2008

Effect of electroacupuncture on inflammatory signal expression in local tissues of rats with chronic pelvic pain syndrome.Nov 30, 2022

Electroacupuncture can effectively relieve pain in chronic pelvic pain syndrome.Jun 24, 2022

Eriodictyol ameliorates lipopolysaccharide-induced acute lung injury.Feb 29, 2020

Fermented C. longa might be a useful material for preventing impairment of learning and memory.Jul 16, 2017

Ferulic acid may be a potential therapy for osteoarthritis.Jun 01, 2021

Formononetin may be a promising candidate for the treatment and prevention of osteoarthritis.Jul 31, 2019

Fucoxanthin-rich fraction from Sargassum fusiformis alleviates particulate matter-induced inflammation.Dec 31, 2020

Gallic acid and myricetin-rich Labisia pumila extract mitigated multiple diabetic eye disorders in rats.Oct 06, 2021

Garlic extracts have potential use in the prevention and management of ulcerative colitis.Nov 08, 2022

Gastroprotective effect of Berberis vulgaris on ethanol-induced gastric mucosal injury.Dec 31, 2021

Genipin inhibited LPS-induced inflammatory response by activating Nrf2 signalling pathway in BV2 microglia.Sep 30, 2017

Genipin, a compound found within gardenia fruit, inhibits microglial activation in a mouse model of brain inflammation. Feb 01, 2010

Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals.Aug 31, 2020

Ginger's anti-inflammatory activity is mediated by inhibiting macrophage and neutrophils activation.Dec 14, 2017

Ginseng berry prevents alcohol-induced liver damage.Jul 17, 2019

Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2.Jan 31, 2019

Hesperidin may be a promising modulator in preventing renal cancer.Aug 10, 2018

Honokiol has the ability to inhibit UVB-induced immunosuppression in preclinical model.May 09, 2017

Hops (H. lupulus) has anti-inflammatory activity in a mouse model of athritis. Jul 16, 1996

In vivo anti-inflammatory activity of the peels and pulps of Cucumis melo.Jun 11, 2019

kaempferol-3-O-glucorhamnosidein a potent anti-inflammatory in vitro and in vivo.Dec 06, 2018

Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats.Aug 31, 2018

Korean red ginseng is promising for asthma treatment.Jun 30, 2021

LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.Dec 31, 2016

Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels.Mar 31, 2022

Melittin mitigated ulcerative colitis pathogenesis and could be considered as a potent and promising therapeutic alternative treatment.Sep 27, 2020

Modulation of Th1/Th2 cytokines and inflammatory mediators by hydroxychavicol in adjuvant induced arthritic tissues.Dec 31, 2009

Neuroprotective effect of fisetin against the cerebral ischemia-reperfusion damage.Feb 21, 2021

Paeonol may be a potential therapeutic agent in the treatment of osteoarthritis.Sep 30, 2017

Pharmacological evaluation of carvacrol anti-migraine potential.Jan 31, 2023

Portulaca oleracea extract dose-dependently displays anti-oxidant and anti-inflammatory activity against lipopolysaccharide-induced acute lung injury.Dec 31, 2018

Preclinical rodent models of arthritis and acute inflammation indicate immunomodulatory and anti-inflammatory properties of Juglans regia extracts.Dec 31, 2021

Protective effect of carotenoid extract from orange-fleshed sweet potato on gastric ulcer.Dec 16, 2021

Protective effect of chrysin on indomethacin induced gastric ulcer.Jan 13, 2022

Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB.Jul 31, 2019

Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats.Jan 31, 2020

Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever.May 06, 2012

Quercetin and low level laser therapy promote wound healing process in diabetic rats.Feb 20, 2018

Rutin inhibited the advanced glycation end products-stimulated inflammatory response and extra-cellular matrix degeneration.Jan 21, 2021

Solidagenone from Solidago chilensis Meyen inhibits skin inflammation in experimental models.Dec 31, 2020

Spirulina consumption effectively reduces anti-inflammatory and pain related infectious diseases.May 20, 2019

Tangeretin might have potential as a therapeutic agent for the treatment of rheumatoid arthritis.Dec 31, 2018

Taxifolin prevents β-amyloid-induced impairments of synaptic formation and deficits of memory.Dec 31, 2017

Postaglandin PGE2 downregulation

View the Evidence:
162 Abstracts with Postaglandin PGE2 downregulation Research