Postaglandin PGE2 downregulation

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97 Substances Researched for Postaglandin PGE2 downregulation
NameACCKFocus
Ginger313Locked
Turmeric313Locked
Black Pepper211Locked
Pterocarpus marsupium110Locked
Pterostilbene110Locked
Seaweed: Brown 27Locked
Astragaloside15Locked
Flavonoids45Locked
Niacinamide15Locked
Resveratrol15Locked
Sesamin15Locked
Hesperidin24Locked
Kaempferol24Locked
Spirulina24Locked
Curcumin33Locked
Fisetin23Locked
Formononetin23Locked
Magnolol23Locked
Paeonol23Locked
Peony33Locked
6-Shogaol12Locked
Asiatic Acid22Locked
Basil12Locked
Bee Venom12Locked
Black Currant12Locked
Black Raspberry12Locked
Bromelain12Locked
Citral12Locked
Crocin22Locked
D-Limonene12Locked
Delphinidin12Locked
Eriodictyol12Locked
Fermented Foods and Beverages22Locked
Fucoxanthin 12Locked
Gardenia12Locked
Genipin12Locked
Geraniol 12Locked
Ginseng12Locked
Ginsenosides12Locked
Guduchi 12Locked
Honeydew (melon)12Locked
Honeysuckle12Locked
Honokiol12Locked
Hops12Locked
Isoliquiritigenin12Locked
Lime12Locked
Phloretin22Locked
Puerarin12Locked
Purslane12Locked
Quercetin12Locked
Royal Jelly12Locked
Tangeretin 12Locked
Turmeric: Fermented12Locked
Urolithin A 12Locked
Vitamin E12Locked
Apple11Locked
Baicalein11Locked
Banana11Locked
Beta-Caryophyllene11Locked
Biochanin A11Locked
Butterbur11Locked
Caffeoylquinic Acids11Locked
Chia11Locked
Chokeberry11Locked
Chrysanthemum Morifolium11Locked
Citrus Peel 11Locked
Cocoa11Locked
Coenzyme Q1011Locked
Coumestrol11Locked
Dandelion 11Locked
Emodin11Locked
Genistein11Locked
Glycyrrhizin11Locked
Gotu Kola11Locked
Guava11Locked
Lotus 11Locked
Maple Syrup11Locked
Moringa oleifera11Locked
Myricetin11Locked
Nigella sativa (aka Black Seed)11Locked
Nobiletin 11Locked
Oleuropein11Locked
Orange: Mandarin11Locked
Oridonin11Locked
P-Coumaric Acid11Locked
Paeoniflorin11Locked
Passion Flower11Locked
Patchouli11Locked
Pine Needle11Locked
Poria cocos11Locked
Red Clover11Locked
Selenium11Locked
Skullcap: Chinese11Locked
Sulforaphane11Locked
Tanshinone IIA11Locked
Thymoquinone11Locked
Wogonin11Locked

View the Evidence:
179 Abstracts with Postaglandin PGE2 downregulation Research

[+]

Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids.Nov 30, 2019

Pubmed Data : Inflammopharmacology. 2019 Dec ;27(6):1101-1112. Epub 2019 Aug 12. PMID: 31407195
Article Published Date : Nov 30, 2019
Study Type : Human Study
Additional Links
Substances : Frankincense
Diseases : Brain Ischemia, Stroke
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Neuroprotective Agents, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Herbal formulation turmeric extract, black pepper, and ginger versus naproxen for chronic knee osteoarthritis.Jul 31, 2020

Pubmed Data : Phytother Res. 2020 Aug ;34(8):2067-2073. Epub 2020 Mar 16. PMID: 32180294
Article Published Date : Jul 31, 2020
Study Type : Human Study
Additional Links
Substances : Black Pepper, Ginger, Turmeric
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
Additional Keywords : Natural Substances Versus Drugs
[+]

Local ice cryotherapy had beneficial effects in human non-septic knee arthritis.Jul 29, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Arthritis Res Ther. 2019 Jul 30 ;21(1):180. Epub 2019 Jul 30. PMID: 31362785
Article Published Date : Jul 29, 2019
Study Type : Human Study
Additional Links
Diseases : Arthritis
Therapeutic Actions : Cryotherapy
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Vascular Endothelial Growth Factor Inhibitors
[+]

Photobiomodulation therapy is able to modulate PGE2 levels in patients with chronic non-specific low back pain.Jan 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Lasers Surg Med. 2021 Feb ;53(2):236-244. Epub 2020 Apr 24. PMID: 32330315
Article Published Date : Jan 31, 2021
Study Type : Human Study
Additional Links
Diseases : Low Back Pain
Pharmacological Actions : Analgesics, Postaglandin PGE2 downregulation
[+]

Pterocarpus marsupium extract exhibits anti-inflammatory activity in human subjects. May 01, 2005

Pubmed Data : Planta Med. 2005 May;71(5):387-92. PMID: 15931573
Article Published Date : May 01, 2005
Study Type : Human Study
Additional Links
Substances : Pterocarpus marsupium, Pterostilbene
Diseases : Inflammation
Pharmacological Actions : Cyclooxygenase Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts, Stilbenes
[+]

Astragaloside potentially serve as a promising and effective therapeutic agent for treating osteoarthritis patients.Jul 31, 2019

Pubmed Data : Immunopharmacol Immunotoxicol. 2019 Aug ;41(4):497-503. Epub 2019 Jul 11. PMID: 31293216
Article Published Date : Jul 31, 2019
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : Astragaloside
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Betulinic acid exerts anti-inflammatory activity in human periodontal ligament cells stimulated with lipopolysaccharide or high glucose.May 08, 2022

Pubmed Data : Endocr Metab Immune Disord Drug Targets. 2022 May 9. Epub 2022 May 9. PMID: 35538811
Article Published Date : May 08, 2022
Study Type : Human In Vitro
Additional Links
Substances : Betulinic acid
Diseases : Diabetic Complications, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Marine alga Ecklonia cava extract and dieckol attenuate prostaglandin E2 production in HaCaT keratinocytes exposed to airborne particulate matter.Jun 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Antioxidants (Basel). 2019 Jun 21 ;8(6). Epub 2019 Jun 21. PMID: 31234405
Article Published Date : Jun 20, 2019
Study Type : Human In Vitro
Additional Links
Substances : Seaweed: Brown
Diseases : Air Pollution Linked Toxicity, Lung Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Niacinamide mitigates SASP-related inflammation induced by environmental stressors in human epidermal keratinocytes and skin.Sep 30, 2020

Pubmed Data : Int J Cosmet Sci. 2020 Oct ;42(5):501-511. Epub 2020 Aug 20. PMID: 32657437
Article Published Date : Sep 30, 2020
Study Type : Human In Vitro
Additional Links
Substances : Niacinamide
Diseases : Inflammation, Skin Diseases: Inflammatory
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Postaglandin PGE2 downregulation
[+]

Resveratrol functions as a suppressor of particulate matter induced inflammatory signalling pathways.May 07, 2017

Pubmed Data : Int J Biochem Cell Biol. 2017 May 8 ;88:113-123. Epub 2017 May 8. PMID: 28495310
Article Published Date : May 07, 2017
Study Type : Human In Vitro
Additional Links
Substances : Resveratrol
Diseases : Air Pollution Linked Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Sesamin showed anti-inflammatory effects in IL-1β-stimulated chondrocytes.Dec 12, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2016 Dec 13 ;7(50):83720-83726. PMID: 27863411
Article Published Date : Dec 12, 2016
Study Type : Human In Vitro
Additional Links
Substances : Sesamin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Nrf2 activation, Postaglandin PGE2 downregulation
[+]

Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.Oct 04, 2022

Pubmed Data : Int J Biol Macromol. 2022 Oct 5. Epub 2022 Oct 5. PMID: 36208806
Article Published Date : Oct 04, 2022
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 alpha downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Limonin inhibits IL-1 β-induced inflammation and catabolism in chondrocytes and ameliorates osteoarthritis.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2021 ;2021:7292512. Epub 2021 Nov 9. PMID: 34795843
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Citrus Triterpenoids
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nrf2 activation, Postaglandin PGE2 downregulation
[+]

The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study Mar 25, 2020

Pubmed Data : Food Funct. 2020 Mar 26 ;11(3):2654-2666. PMID: 32159191
Article Published Date : Mar 25, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Hesperidin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Nrf2 activation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

6-Shogaol reduces progression of experimental endometriosis.Oct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Korean J Physiol Pharmacol. 2018 Nov ;22(6):627-636. Epub 2018 Oct 25. PMID: 30402023
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : 6-Shogaol
Diseases : Endometriosis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

Acacetin attenuates neuroinflammation.Jun 30, 2012

Pubmed Data : Neurochem Res. 2012 Jul ;37(7):1560-7. Epub 2012 Mar 24. PMID: 22447574
Article Published Date : Jun 30, 2012
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Alzheimer's Disease, Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Postaglandin PGE2 downregulation
[+]

Activities of Andrographis paniculata tablet on Cox-2 and prostaglandin expression of placental of Plasmodium berghei infection.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Parasitol. 2021 Jan-Mar;16(1):43-51. PMID: 33786046
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Andrographis
Diseases : Malaria
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.May 09, 2019

Pubmed Data : J Ethnopharmacol. 2019 May 10 ;235:460-471. Epub 2019 Feb 13. PMID: 30771518
Article Published Date : May 09, 2019
Study Type : Animal Study
Additional Links
Substances : Black Currant
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-4 upregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Andrographolide may have therapeutic value in the treatment of stroke.Sep 30, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Br J Pharmacol. 2010 Oct ;161(3):668-79. PMID: 20880404
Article Published Date : Sep 30, 2010
Study Type : Animal Study
Additional Links
Substances : Andrographis, Andrographolide
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anti-colonic inflammation by black raspberries.Jun 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cancer Prev. 2020 Jun 30 ;25(2):119-125. PMID: 32647653
Article Published Date : Jun 29, 2020
Study Type : Animal Study
Additional Links
Substances : Black Raspberry
Diseases : Gastrointestinal Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate.Aug 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Inflammopharmacology. 2021 Sep 1. Epub 2021 Sep 1. PMID: 34468900
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Palmitoylethanolamide
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Osteoprotective , Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Antiosteoarthritic effect of morroniside in chondrocyte inflammation and destabilization of medial meniscus-induced mouse model.Mar 14, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Mar 15 ;22(6). Epub 2021 Mar 15. PMID: 33804203
Article Published Date : Mar 14, 2021
Study Type : Animal Study
Additional Links
Substances : Dogwood
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Antipyretic effects of citral and possible mechanisms of action. Sep 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Inflammation. 2017 Oct ;40(5):1735-1741. PMID: 28667503
Article Published Date : Sep 30, 2017
Study Type : Animal Study
Additional Links
Substances : Citral
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Anti-pyretic , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Astilbin influences the progression of osteoarthritis in rats by down-regulation of PGE-2 expression via the NF-κB pathway.May 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2020 Jun ;8(12):766. PMID: 32647691
Article Published Date : May 31, 2020
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

Basil may be used as a nutritional supplement or therapeutic drug to protect against aspirin-induced gastric ulcers.Aug 14, 2018

Pubmed Data : Food Funct. 2018 Aug 15 ;9(8):4457-4468. PMID: 30073231
Article Published Date : Aug 14, 2018
Study Type : Animal Study
Additional Links
Substances : Basil
Diseases : Aspirin-Induced Toxicity , Gastric Ulcer
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Gastroprotective, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Aspirin
[+]

Berberine alleviates inflammation and suppresses PLA2-COX-2-PGE2-EP2 pathway through targeting gut microbiota in DSS-induced ulcerative colitis.Feb 04, 2024

Pubmed Data : Biochem Biophys Res Commun. 2024 Feb 5 ;695:149411. Epub 2023 Dec 19. PMID: 38154262
Article Published Date : Feb 04, 2024
Study Type : Animal Study
Additional Links
Substances : Berberine
Diseases : Colitis, Inflammation, Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in a sciatic nerve ligation model.Jan 10, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2021 Jan 11 ;11(1):289. Epub 2021 Jan 11. PMID: 33432004
Article Published Date : Jan 10, 2021
Study Type : Animal Study
Additional Links
Substances : Bromelain
Diseases : Neuropathic Pain
Pharmacological Actions : Anti-Anxiety Agents, Antinoceceptive , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

C-phycocyanin relieved symptoms associated with cyclophosphamide-induced cystitis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2019 ;2019:8424872. Epub 2019 Jul 29. PMID: 31467580
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : C-phycocyanin
[+]

Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathway.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:963506. Epub 2022 Aug 10. PMID: 36034791
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Celastrol
Diseases : Osteoarthritis: Knee
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

Citrus hystrix leaf extract attenuated diabetic-cataract in STZ-rats.Jun 14, 2020

Pubmed Data : J Food Biochem. 2020 Jun 15:e13258. Epub 2020 Jun 15. PMID: 32539198
Article Published Date : Jun 14, 2020
Study Type : Animal Study
Additional Links
Substances : Lime
Diseases : Diabetes: Cataract
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis.Mar 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2017 Apr ;15(4):2339-2346. Epub 2017 Feb 22. PMID: 28260017
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : D-Limonene
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Postaglandin PGE2 downregulation
[+]

Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis.Jan 31, 2012

Pubmed Data : Dig Dis Sci. 2012 Feb ;57(2):355-63. Epub 2011 Sep 8. PMID: 21901258
Article Published Date : Jan 31, 2012
Study Type : Animal Study
Additional Links
Substances : Kaempferol
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
[+]

Dietary turmeric led to a decrease in DMBA-induced tumor burden and multiplicity in animals. Oct 31, 2008

Pubmed Data : Toxicol Appl Pharmacol. 2008 Nov 1 ;232(3):428-39. Epub 2008 Jul 19. PMID: 18687351
Article Published Date : Oct 31, 2008
Study Type : Animal Study
Additional Links
Substances : Turmeric
Diseases : Oral Cancer, Oral Cancer: Prevention
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

Effect of electroacupuncture on inflammatory signal expression in local tissues of rats with chronic pelvic pain syndrome.Nov 30, 2022

Pubmed Data : J Tradit Chin Med. 2022 Dec ;42(6):965-971. PMID: 36378055
Article Published Date : Nov 30, 2022
Study Type : Animal Study
Additional Links
Diseases : Chronic Pelvic Pain Syndrome
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Electroacupuncture can effectively relieve pain in chronic pelvic pain syndrome.Jun 24, 2022

Pubmed Data : Zhen Ci Yan Jiu. 2022 Jun 25 ;47(6):531-6. PMID: 35764521
Article Published Date : Jun 24, 2022
Study Type : Animal Study
Additional Links
Diseases : Chronic Pelvic Pain Syndrome
Therapeutic Actions : Electroacupuncture
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Eriodictyol ameliorates lipopolysaccharide-induced acute lung injury.Feb 29, 2020

Pubmed Data : J Biochem Mol Toxicol. 2020 Mar ;34(3):e22434. Epub 2019 Dec 20. PMID: 31860763
Article Published Date : Feb 29, 2020
Study Type : Animal Study
Additional Links
Substances : Eriodictyol
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

Fermented C. longa might be a useful material for preventing impairment of learning and memory.Jul 16, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMC Complement Altern Med. 2017 Jul 17 ;17(1):367. Epub 2017 Jul 17. PMID: 28716085
Article Published Date : Jul 16, 2017
Study Type : Animal Study
Additional Links
Substances : Turmeric: Fermented
Diseases : Cognitive Decline/Dysfunction, Memory Disorders
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
[+]

Ferulic acid may be a potential therapy for osteoarthritis.Jun 01, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Immun Inflamm Dis. 2021 Jun 2. Epub 2021 Jun 2. PMID: 34078001
Article Published Date : Jun 01, 2021
Study Type : Animal Study
Additional Links
Substances : Ferulic acid
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Postaglandin PGE2 downregulation
[+]

Formononetin may be a promising candidate for the treatment and prevention of osteoarthritis.Jul 31, 2019

Pubmed Data : Inflammation. 2019 Aug ;42(4):1426-1440. PMID: 30937838
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Formononetin
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

Fucoxanthin-rich fraction from Sargassum fusiformis alleviates particulate matter-induced inflammation.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Rep. 2021 ;8:349-358. Epub 2021 Feb 6. PMID: 33665132
Article Published Date : Dec 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoxanthin , Seaweed: Brown
Diseases : Air Pollution Linked Toxicity, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

Gallic acid and myricetin-rich Labisia pumila extract mitigated multiple diabetic eye disorders in rats.Oct 06, 2021

Pubmed Data : J Food Biochem. 2021 Oct 7:e13948. Epub 2021 Oct 7. PMID: 34622461
Article Published Date : Oct 06, 2021
Study Type : Animal Study
Additional Links
Substances : Gallic Acid, Myricetin
Diseases : Diabetic Complications, Diabetic Retinopathy
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Garlic extracts have potential use in the prevention and management of ulcerative colitis.Nov 08, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2022 Nov 9 ;11(22). Epub 2022 Nov 9. PMID: 36429152
Article Published Date : Nov 08, 2022
Study Type : Animal Study
Additional Links
Substances : Garlic
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Gastroprotective effect of Berberis vulgaris on ethanol-induced gastric mucosal injury.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Avicenna J Phytomed. 2022 Jan-Feb;12(1):30-41. PMID: 35145893
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Barberry
Diseases : Alcohol Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, Postaglandin PGE2 downregulation
[+]

Genipin inhibited LPS-induced inflammatory response by activating Nrf2 signalling pathway in BV2 microglia.Sep 30, 2017

Pubmed Data : Neurochem Res. 2017 Oct ;42(10):2769-2776. Epub 2017 May 11. PMID: 28497344
Article Published Date : Sep 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Genipin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Nrf2 activation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Genipin, a compound found within gardenia fruit, inhibits microglial activation in a mouse model of brain inflammation. Feb 01, 2010

Pubmed Data : Int Immunopharmacol. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20123040
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Gardenia
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals.Aug 31, 2020

Pubmed Data : Int Immunopharmacol. 2020 Sep ;86:106713. Epub 2020 Jun 23. PMID: 32590318
Article Published Date : Aug 31, 2020
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Geraniol
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginger's anti-inflammatory activity is mediated by inhibiting macrophage and neutrophils activation.Dec 14, 2017

Pubmed Data : J Ethnopharmacol. 2017 Dec 15. Epub 2017 Dec 15. PMID: 29253614
Article Published Date : Dec 14, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Ginger
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginseng berry juice regulates the inflammation in acute ulcerative mouse models and the major bioactive substances are ginsenosides.Mar 31, 2024

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2024 Apr 1 ;16(7). Epub 2024 Apr 1. PMID: 38613064
Article Published Date : Mar 31, 2024
Study Type : Animal Study
Additional Links
Substances : Ginseng, Ginsenosides
Diseases : Alcohol Toxicity , Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, interleukin-13 down-regulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginseng berry prevents alcohol-induced liver damage.Jul 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2019 Jul 18 ;20(14). Epub 2019 Jul 18. PMID: 31323789
Article Published Date : Jul 17, 2019
Study Type : Animal Study
Additional Links
Substances : Ginseng
Diseases : Alcoholic Liver Disease
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ginsenoside metabolite compound K exerts anti-inflammatory and analgesic effects via downregulating COX2.Jan 31, 2019

Pubmed Data : Inflammopharmacology. 2019 Feb ;27(1):157-166. Epub 2018 Jun 26. PMID: 29946770
Article Published Date : Jan 31, 2019
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Inflammation
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Ginsenoside Rb1 promotes hepatic glycogen synthesis to ameliorate T2DM.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Diabetes Metab Syndr Obes. 2023 ;16:3223-3234. Epub 2023 Oct 17. PMID: 37867629
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Diabetes Mellitus: Type 2
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Postaglandin PGE2 downregulation
[+]

Hesperidin may be a promising modulator in preventing renal cancer.Aug 10, 2018

Pubmed Data : Environ Toxicol. 2018 Aug 11. Epub 2018 Aug 11. PMID: 30098279
Article Published Date : Aug 10, 2018
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Liver Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation , Vascular Endothelial Growth Factor Regulator
[+]

Honokiol has the ability to inhibit UVB-induced immunosuppression in preclinical model.May 09, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2017 May 10 ;7(1):1657. Epub 2017 May 10. PMID: 28490739
Article Published Date : May 09, 2017
Study Type : Animal Study
Additional Links
Substances : Honokiol
Diseases : Skin Cancer: Prevention, Ultraviolet Radiation Induced Damage
Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Postaglandin PGE2 downregulation
[+]

Hops (H. lupulus) has anti-inflammatory activity in a mouse model of athritis. Jul 16, 1996

Pubmed Data : Biochem Biophys Res Commun. 1996 Jul 16;224(2):358-61. PMID: 16534727
Article Published Date : Jul 16, 1996
Study Type : Animal Study
Additional Links
Substances : Hops
Diseases : Arthritis, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

In vivo anti-inflammatory activity of the peels and pulps of Cucumis melo.Jun 11, 2019

Pubmed Data : J Ethnopharmacol. 2019 Jun 12 ;237:245-254. Epub 2019 Mar 9. PMID: 30857984
Article Published Date : Jun 11, 2019
Study Type : Animal Study
Additional Links
Substances : Honeydew (melon)
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

kaempferol-3-O-glucorhamnosidein a potent anti-inflammatory in vitro and in vivo.Dec 06, 2018

Pubmed Data : Toxicol Appl Pharmacol. 2018 Dec 7. Epub 2018 Dec 7. PMID: 30528763
Article Published Date : Dec 06, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Inflammation, Klebsiella Infections
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Kolaviron attenuates diclofenac-induced nephrotoxicity in male Wistar rats.Aug 31, 2018

Pubmed Data : Appl Physiol Nutr Metab. 2018 Sep ;43(9):956-968. Epub 2018 May 30. PMID: 29847737
Article Published Date : Aug 31, 2018
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Kidney Damage: Drug-Induced, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation , Renoprotective
Problem Substances : Diclofenac
[+]

Korean red ginseng is promising for asthma treatment.Jun 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ginseng Res. 2021 Jul ;45(4):482-489. Epub 2020 Oct 17. PMID: 34295208
Article Published Date : Jun 30, 2021
Study Type : Animal Study
Additional Links
Substances : Ginseng (Korean)
Diseases : Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-12 downregulation, Interleukin-4 downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

Lactobacillus plantarum Zhang-LL inhibits colitis-related tumorigenesis.Oct 24, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Oct 25 ;15(21). Epub 2023 Oct 25. PMID: 37960165
Article Published Date : Oct 24, 2023
Study Type : Animal Study
Additional Links
Substances : Lactobacillus plantarum
Diseases : Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Chemopreventive, Gastrointestinal Agents, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pain Res Manag. 2017 ;2017:4792489. Epub 2017 Apr 2. PMID: 28469528
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Diseases : Wound Healing
Therapeutic Actions : Light-Emitting Diodes (LEDs) Therapy
Pharmacological Actions : Analgesics, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Limonin modulated immune and inflammatory responses to suppress colorectal adenocarcinoma in mice model.Aug 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2021 Sep ;394(9):1907-1915. Epub 2021 May 19. PMID: 34009457
Article Published Date : Aug 31, 2021
Study Type : Animal Study
Additional Links
Substances : Citrus Triterpenoids
Diseases : Colorectal Cancer, Inflammation, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Immunomodulatory, Malondialdehyde Down-regulation, Nrf2 activation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels.Mar 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Saudi J Biol Sci. 2022 Apr ;29(4):2958-2968. Epub 2022 Jan 18. PMID: 35531206
Article Published Date : Mar 31, 2022
Study Type : Animal Study
Additional Links
Substances : Melatonin
Diseases : Cerebral Hypoperfusion
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Melittin mitigated ulcerative colitis pathogenesis and could be considered as a potent and promising therapeutic alternative treatment.Sep 27, 2020

Pubmed Data : Chem Biol Interact. 2020 Sep 28 ;331:109276. Epub 2020 Sep 28. PMID: 33002459
Article Published Date : Sep 27, 2020
Study Type : Animal Study
Additional Links
Substances : Bee Venom
Diseases : Ulcerative Colitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Modulation of Th1/Th2 cytokines and inflammatory mediators by hydroxychavicol in adjuvant induced arthritic tissues.Dec 31, 2009

Pubmed Data : Cytokine. 2010 Jan ;49(1):114-21. Epub 2009 Sep 25. PMID: 19782577
Article Published Date : Dec 31, 2009
Study Type : Animal Study
Additional Links
Substances : Betel, Polyphenols
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Neuroprotective effect of fisetin against the cerebral ischemia-reperfusion damage.Feb 21, 2021

Pubmed Data : Inflammation. 2021 Feb 22. Epub 2021 Feb 22. PMID: 33616827
Article Published Date : Feb 21, 2021
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Neuroprotective effects of Ginkgolide B in focal cerebral ischemia.Jan 14, 2021

Pubmed Data : Phytother Res. 2021 Jan 15. Epub 2021 Jan 15. PMID: 33452698
Article Published Date : Jan 14, 2021
Study Type : Animal Study
Additional Links
Substances : Ginkgo biloba
Diseases : Cerebral Ischemia
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Paeonol may be a potential therapeutic agent in the treatment of osteoarthritis.Sep 30, 2017

Pubmed Data : Inflammation. 2017 Oct ;40(5):1698-1706. PMID: 28695367
Article Published Date : Sep 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Osteoarthritis
Pharmacological Actions : Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
[+]

Parthenolide reduces cell proliferation and prostaglandin E2 [corrected] in human endometriotic stromal cells and inhibits development of endometriosis.Sep 30, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Fertil Steril. 2013 Oct ;100(4):1170-8. Epub 2013 Jul 19. PMID: 23876538
Article Published Date : Sep 30, 2013
Study Type : Animal Study
Additional Links
Substances : Parthenolide
Diseases : Endometriosis
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pharmacological evaluation of carvacrol anti-migraine potential.Jan 31, 2023

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2023 Feb 1. Epub 2023 Feb 1. PMID: 36723608
Article Published Date : Jan 31, 2023
Study Type : Animal Study
Additional Links
Diseases : Migraines
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Portulaca oleracea extract dose-dependently displays anti-oxidant and anti-inflammatory activity against lipopolysaccharide-induced acute lung injury.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2019 Jan 1 ;24(1). Epub 2019 Jan 1. PMID: 30609661
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Purslane
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Lung Injury: Acute
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Preclinical rodent models of arthritis and acute inflammation indicate immunomodulatory and anti-inflammatory properties of Juglans regia extracts.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:1695701. Epub 2022 Apr 5. PMID: 35422870
Article Published Date : Dec 31, 2021
Study Type : Animal Study
Additional Links
Substances : Walnut
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effect of carotenoid extract from orange-fleshed sweet potato on gastric ulcer.Dec 16, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2021 Dec 17 ;14(12). Epub 2021 Dec 17. PMID: 34959718
Article Published Date : Dec 16, 2021
Study Type : Animal Study
Additional Links
Substances : Sweet Potato
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Gastroprotective, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
[+]

Protective effect of chrysin on indomethacin induced gastric ulcer.Jan 13, 2022

Pubmed Data : Biotech Histochem. 2022 Jan 14:1-14. Epub 2022 Jan 14. PMID: 35026960
Article Published Date : Jan 13, 2022
Study Type : Animal Study
Additional Links
Substances : Chrysin
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-Ulcer Agents, Cyclooxygenase 2 Inhibitors, Gastrointestinal Agents, Gastroprotective, Postaglandin PGE2 downregulation
[+]

Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB.Jul 31, 2019

Pubmed Data : Inflammopharmacology. 2019 Aug ;27(4):809-816. Epub 2018 Jun 26. PMID: 29943151
Article Published Date : Jul 31, 2019
Study Type : Animal Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Cerebral Ischemia, Sepsis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effect of royal jelly against diclofenac-induced hepato-renal damage and gastrointestinal ulcerations in rats.Jan 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2020 Feb ;6(2):e03330. Epub 2020 Feb 1. PMID: 32025584
Article Published Date : Jan 31, 2020
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Liver Damage: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Gastroprotective, Hepatoprotective, Postaglandin PGE2 downregulation
Problem Substances : Diclofenac
[+]

Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever.May 06, 2012

Pubmed Data : J Ethnopharmacol. 2012 May 7 ;141(1):322-30. Epub 2012 Feb 28. PMID: 22401764
Article Published Date : May 06, 2012
Study Type : Animal Study
Additional Links
Substances : Puerarin
Diseases : Fever, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Anti-pyretic , Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy
[+]

Quercetin and low level laser therapy promote wound healing process in diabetic rats.Feb 20, 2018

Pubmed Data : Biomed Pharmacother. 2018 Feb 21 ;101:58-73. Epub 2018 Feb 21. PMID: 29477473
Article Published Date : Feb 20, 2018
Study Type : Animal Study
Additional Links
Substances : Quercetin
Diseases : Diabetic Complications, Wound Healing
Therapeutic Actions : Laser Treatment: Low-Level
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Rosmarinic acid ameliorates HCl-induced cystitis.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2023 ;18(7):e0288813. Epub 2023 Jul 18. PMID: 37463180
Article Published Date : Dec 31, 2022
Study Type : Animal Study
Additional Links
Substances : Rosemaric Acid
Diseases : Cystitis
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Rutin inhibited the advanced glycation end products-stimulated inflammatory response and extra-cellular matrix degeneration.Jan 21, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging (Albany NY). 2021 09 22 ;13(18):22134-22147. Epub 2021 Sep 22. PMID: 34550907
Article Published Date : Jan 21, 2021
Study Type : Animal Study
Additional Links
Substances : Rutin
Diseases : Advanced Glycation End products (AGE), Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Solidagenone from Solidago chilensis Meyen inhibits skin inflammation in experimental models.Dec 31, 2020

Pubmed Data : Basic Clin Pharmacol Toxicol. 2021 Jan ;128(1):91-102. Epub 2020 Sep 2. PMID: 32780565
Article Published Date : Dec 31, 2020
Study Type : Animal Study
Additional Links
Substances : Goldenrod
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Spirulina consumption effectively reduces anti-inflammatory and pain related infectious diseases.May 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Infect Public Health. 2019 May 21. Epub 2019 May 21. PMID: 31126833
Article Published Date : May 20, 2019
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Tangeretin might have potential as a therapeutic agent for the treatment of rheumatoid arthritis.Dec 31, 2018

Pubmed Data : Pharmacology. 2019 ;104(3-4):187-195. Epub 2019 Jul 25. PMID: 31344704
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Tangeretin
Diseases : Arthritis: Rheumatoid
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interferon Gamma Reducer, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Nrf2 activation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Taxifolin prevents β-amyloid-induced impairments of synaptic formation and deficits of memory.Dec 31, 2017

Pubmed Data : Metab Brain Dis. 2018 08 ;33(4):1069-1079. Epub 2018 Mar 14. PMID: 29542038
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Flavonoids
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, Postaglandin PGE2 downregulation
[+]

The data indicate that sinomenine had a protective role in inflammatory pain.Apr 04, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Med Sci Monit. 2018 Apr 5 ;24:2018-2024. Epub 2018 Apr 5. PMID: 29620048
Article Published Date : Apr 04, 2018
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The neuroprotective effect of pterostilbene on oxaliplatin-induced peripheral neuropathy.Jan 03, 2023

Pubmed Data : Life Sci. 2023 Jan 4:121364. Epub 2023 Jan 4. PMID: 36610639
Article Published Date : Jan 03, 2023
Study Type : Animal Study
Additional Links
Substances : Pterostilbene
Diseases : Chemotherapy-Induced Toxicity: Peripheral Neuropathy
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results suggest that the anti-inflammatory effect of delphinidin alleviated inflammation in a spinal cord injury model.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2017 Dec ;14(6):5583-5588. Epub 2017 Sep 27. PMID: 29285096
Article Published Date : Nov 30, 2017
Study Type : Animal Study
Additional Links
Substances : Delphinidin
Diseases : Spinal Cord Injuries
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

This reports of Caulis Lonicerae japonicae especially its anti-inflammatory effects and correlative components.May 31, 2016

Pubmed Data : Phytomedicine. 2016 Jun 1 ;23(6):597-610. Epub 2016 Feb 26. PMID: 27161401
Article Published Date : May 31, 2016
Study Type : Animal Study
Additional Links
Substances : Honeysuckle
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

This research suggested that magnolol possessed a new therapeutic potential for the development of osteoarthritis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2019 ;10:393. Epub 2019 Apr 16. PMID: 31040782
Article Published Date : Dec 31, 2018
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Thymol ameliorates 5-fluorouracil-induced intestinal mucositis.Oct 18, 2021

Pubmed Data : J Biochem Mol Toxicol. 2021 Oct 19:e22932. Epub 2021 Oct 19. PMID: 34665902
Article Published Date : Oct 18, 2021
Study Type : Animal Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: 5-fluorouracil , Mucositis
Pharmacological Actions : Anti-Inflammatory Agents, Beta-Defensin-2 Up-Regulation, Chemoprotective Agents, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Transforming growth factor beta (TGF-β) inhibitor
[+]

Tinospora cordifolia ameliorated titanium dioxide nanoparticle-induced toxicity.Jan 31, 2021

Pubmed Data : Comp Biochem Physiol C Toxicol Pharmacol. 2021 Feb ;240:108908. Epub 2020 Oct 3. PMID: 33022381
Article Published Date : Jan 31, 2021
Study Type : Animal Study
Additional Links
Substances : Guduchi
Diseases : Titanium Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Heme oxygenase-1 up-regulation, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Nrf2 activation, Postaglandin PGE2 downregulation
Problem Substances : Titanium Dioxide, Titanium Nanoparticles
[+]

Urolithin A may be adopted as a new therapeutic agent for the treatment of osteoarthritis.Sep 08, 2019

Pubmed Data : Food Funct. 2019 Sep 9. Epub 2019 Sep 9. PMID: 31497826
Article Published Date : Sep 08, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Urolithin A
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Vitamin E-induced decrease in influenza viral titre is mediated through enhancement of Th1 cytokines.Jul 31, 2000

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Immunology. 2000 Aug ;100(4):487-93. PMID: 10929076
Article Published Date : Jul 31, 2000
Study Type : Animal Study
Additional Links
Substances : Vitamin E
Diseases : Influenza A
Pharmacological Actions : Immunostimulatory, Interferon Gamma Reducer, Interleukin-1 beta downregulation, Interleukin-2 upregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Oridonin inhibits LPS-induced inflammation in human gingival fibroblasts by activating PPARγ.Jun 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 Jul ;72:301-307. Epub 2019 Apr 18. PMID: 31005040
Article Published Date : Jun 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Oridonin
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
[+]

2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside has anti-inflammatory activity and could be applied as a compound for treatment of osteoarthritis drug.Mar 02, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2018 Mar 3 ;23(3). Epub 2018 Mar 3. PMID: 29510478
Article Published Date : Mar 02, 2018
Study Type : In Vitro Study
Additional Links
Diseases : Lipopolysaccharide-Induced Toxicity, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Postaglandin PGE2 downregulation
[+]

A guava leaf extract contains potential therapeutic agents, which regulate NF-κB activation, for the treatment of inflammatory conditions.Oct 31, 2015

Pubmed Data : Fish Shellfish Immunol. 2015 Nov ;47(1):85-92. Epub 2015 Aug 29. PMID: 26327113
Article Published Date : Oct 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids, Guava
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response, Plant Extracts
[+]

A polar extract of Curcuma longa protects cartilage homeostasisJan 07, 2018

Pubmed Data : Inflammopharmacology. 2018 Jan 8. Epub 2018 Jan 8. PMID: 29313174
Article Published Date : Jan 07, 2018
Study Type : In Vitro Study
Additional Links
Substances : Turmeric
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Interleukin-8 downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

A systematic review of the effect of Centella asiatica on wound healing.Jan 09, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Environ Res Public Health. 2022 03 10 ;19(6). Epub 2022 Mar 10. PMID: 35328954
Article Published Date : Jan 09, 2022
Study Type : Review
Additional Links
Substances : Gotu Kola
Diseases : Wound Healing
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Acetyl-11-Keto- β-boswellic acid (AKBA) prevents lipopolysaccharide-induced inflammation and cytotoxicity on H9C2 cells.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2022 ;2022:2620710. Epub 2022 Mar 30. PMID: 35399644
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Anti-inflammatory action of herbal medicine comprised of Scutellaria baicalensis and Chrysanthemum morifolium.May 23, 2020

Pubmed Data : Biosci Biotechnol Biochem. 2020 May 24:1-11. Epub 2020 May 24. PMID: 32448093
Article Published Date : May 23, 2020
Study Type : In Vitro Study
Additional Links
Substances : Chrysanthemum Morifolium, Skullcap: Chinese
Diseases : Chronic Obstructive Pulmonary Disease, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-12 downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Anti-inflammatory and immunomodulatory effects of paeonia lactiflora.Dec 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2011 ;2:10. Epub 2011 Feb 25. PMID: 21687505
Article Published Date : Dec 31, 2010
Study Type : Review
Additional Links
Substances : Peony
Diseases : Inflammation, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Postaglandin PGE2 downregulation
[+]

Anti-inflammatory markers of hops cultivars evaluated by untargeted metabolomics strategy.Mar 31, 2022

Pubmed Data : Chem Biodivers. 2022 Apr ;19(4):e202100966. Epub 2022 Mar 22. PMID: 35267234
Article Published Date : Mar 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Hops
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Anti-inflammatory potential of Lactobacillus reuteri LM1071 via eicosanoid regulation in LPS-stimulated RAW264.7 cells.Jun 30, 2022

Pubmed Data : J Appl Microbiol. 2022 Jul ;133(1):67-75. Epub 2021 Nov 16. PMID: 34688224
Article Published Date : Jun 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Lactobacillus reuteri
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Anti-inflammatory property of the ethanol extract of the root and rhizome of Pogostemon cablin.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2013 ;2013:434151. Epub 2013 Dec 9. PMID: 24385881
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Patchouli
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer.Jul 31, 2018

Pubmed Data : Chem Biol Interact. 2018 Aug 1 ;291:16-28. Epub 2018 Jun 5. PMID: 29879413
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : P-Coumaric Acid
Diseases : Colon Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

Asiatic acid inhibits LPS-induced inflammatory response in endometrial epithelial cells.Feb 28, 2018

Pubmed Data : Microb Pathog. 2018 Mar ;116:195-199. Epub 2018 Jan 31. PMID: 29369796
Article Published Date : Feb 28, 2018
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid, Gotu Kola
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Assessment of anti-inflammatory and antioxidant effects of Citrus unshiu peel flavonoids on LPS-stimulated RAW 264.7 cells.Oct 17, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Plants (Basel). 2021 Oct 18 ;10(10). Epub 2021 Oct 18. PMID: 34686018
Article Published Date : Oct 17, 2021
Study Type : In Vitro Study
Additional Links
Substances : Orange: Mandarin
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Baicalein attenuates neuroinflammation in LPS-treated BV-2 cells.Oct 31, 2023

Pubmed Data : Neurochem Res. 2023 Nov ;48(11):3363-3377. Epub 2023 Jun 5. PMID: 37277556
Article Published Date : Oct 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Baicalein
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , STAT3 Activation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Baicalein, wogonin, and oroxylin A can effectively relieve Aβ25-35-stimulated neuronal apoptosis and inflammation.Nov 01, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2020 Nov 2 ;25(21). Epub 2020 Nov 2. PMID: 33147823
Article Published Date : Nov 01, 2020
Study Type : In Vitro Study
Additional Links
Substances : Baicalein, Wogonin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Baicalin could be a valuable therapeutic for the treatment of neuroinflammation and neurodegenerative diseases.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Res Int. 2022 ;2022:3263446. Epub 2022 Nov 9. PMID: 36408278
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Alzheimer's Disease, Brain Inflammation , Lipopolysaccharide-Induced Toxicity, Neurodegenerative Diseases, Parkinson's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

Banana flower extract suppresses benign prostatic hyperplasia.Oct 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : In Vivo. 2018 Nov-Dec;32(6):1373-1379. PMID: 30348691
Article Published Date : Oct 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Banana
Diseases : Prostatic Hyperplasia
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells.Dec 31, 2016

Pubmed Data : Bioorg Chem. 2017 02 ;70:94-99. Epub 2016 Nov 23. PMID: 27912907
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Poria cocos
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Boswellia serrata extract containing 30% 3-Acetyl-11-keto-boswellic acid attenuates inflammatory mediators.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Physiol. 2021 ;12:735247. Epub 2021 Sep 28. PMID: 34650445
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : acetyl-11-keto-beta-boswellic acid, Frankincense
Diseases : Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Butterbur (P. hybridus) exhibits ant-inflammatory activity in rat microglial (brain) cells. Jan 01, 2005

Pubmed Data : Planta Med. 2005 Jan;71(1):12-9. PMID: 15678367
Article Published Date : Jan 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Butterbur
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Cardamonin attenuates inflammation and oxidative stress in interleukin-1β-stimulated osteoarthritis.May 26, 2021

Pubmed Data : Antioxidants (Basel). 2021 May 27 ;10(6). Epub 2021 May 27. PMID: 34072123
Article Published Date : May 26, 2021
Study Type : In Vitro Study
Additional Links
Substances : Cardamonin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Nrf2 activation, Postaglandin PGE2 downregulation
[+]

Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2023 ;14:1218015. Epub 2023 Sep 13. PMID: 37781708
Article Published Date : Dec 31, 2022
Study Type : Review
Additional Links
Substances : Chlorogenic Acid
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Chondroprotective effect of cynaroside in IL-1 β-induced primary rat chondrocytes and organ explants.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2020 ;2020:9358080. Epub 2020 Jan 24. PMID: 32047580
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

Cocoa polyphenolic extracts may be used for the treatment of inflammation and it's related-diseases.Dec 31, 2015

Pubmed Data : Springerplus. 2016;5:547. Epub 2016 Apr 28. PMID: 27190746
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cocoa
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : 5-lipoxygenase Inhibitor , Anti-Inflammatory Agents, Antioxidants, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Dose Response
[+]

Comparative immunomodulatory activity of Nigella sativa L. preparations on proinflammatory mediators: a focus on asthma.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2018 ;9:1075. Epub 2018 Oct 2. PMID: 30333747
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Alzheimer's Disease, Asthma
Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

CoQ10 may have therapeutic potential for neurodegenerative diseases by inhibiting pro-inflammatory mediators production.Apr 26, 2017

Pubmed Data : Brain Res Bull. 2017 Apr 27 ;131:192-198. Epub 2017 Apr 27. PMID: 28458038
Article Published Date : Apr 26, 2017
Study Type : In Vitro Study
Additional Links
Substances : Coenzyme Q10
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

Coumestrol could be used as a potential anti-catabolic biomaterial for osteoarthritis.Jan 31, 2017

Pubmed Data : Inflammation. 2017 Feb ;40(1):79-91. PMID: 27709316
Article Published Date : Jan 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Coumestrol
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Crocin protects cardiomyocytes against lipopolysaccharide-Induced inflammation.Jul 29, 2019

Pubmed Data : Pharmacol Rep. 2019 Jul 30 ;71(6):1228-1234. Epub 2019 Jul 30. PMID: 31670059
Article Published Date : Jul 29, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cardioprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Crocin protects cardiomyocytes against lipopolysaccharide-induced inflammation.Oct 31, 2019

Pubmed Data : Pharmacol Rep. 2019 Nov ;71(6):1228-1234. Epub 2019 Jul 30. PMID: 32002862
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Crocin
Diseases : Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Curcumin inhibits lipopolysaccharide and lipoteichoic acid-induced expression of proinflammatory cytokines.Nov 30, 2020

Pubmed Data : Mol Biol Rep. 2020 Dec ;47(12):10015-10021. Epub 2020 Nov 10. PMID: 33174083
Article Published Date : Nov 30, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Endometritis, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Curcumin may be a promising agent to alleviate diabetic lung injury and also provides theoretical foundation for the development of diabetes therapy.Jun 25, 2015

Pubmed Data : Clin Exp Pharmacol Physiol. 2015 Jun 26. Epub 2015 Jun 26. PMID: 26111829
Article Published Date : Jun 25, 2015
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Diabetes: Oxidative Stress, Diabetic Complications
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
[+]

Curcumin: An insight to molecular pathways involved in anticancer activity. Jan 21, 2021

Pubmed Data : Mini Rev Med Chem. 2021 Jan 22. Epub 2021 Jan 22. PMID: 33480345
Article Published Date : Jan 21, 2021
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: All
Pharmacological Actions : Anti-Inflammatory Agents, Chemotherapeutic, Cyclooxygenase 2 Inhibitors, Nrf2 activation, Postaglandin PGE2 downregulation , STAT3 Inhibitor
[+]

Discovery of nobiletin from citrus peel as a potent inhibitor of β-amyloid peptide toxicity.Nov 03, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 Nov 4 ;11(11). Epub 2019 Nov 4. PMID: 31689949
Article Published Date : Nov 03, 2019
Study Type : In Vitro Study
Additional Links
Substances : Nobiletin
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Emodin is able to promote the proliferation of chondrocytes.Nov 30, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2018 Dec ;16(6):5384-5389. Epub 2018 Oct 18. PMID: 30542499
Article Published Date : Nov 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Emodin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
[+]

Ethanol extract of Inula helenium has anti-inflammatory effect via the induction of p38 MAPK-dependent HO-1 signaling pathway.Apr 30, 2013

Pubmed Data : Food Chem Toxicol. 2013 May ;55:386-95. Epub 2013 Jan 5. PMID: 23298677
Article Published Date : Apr 30, 2013
Study Type : In Vitro Study
Additional Links
Substances : Elecampane
Diseases : Alcohol Toxicity , Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease.Apr 30, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Heliyon. 2023 May ;9(5):e15406. Epub 2023 Apr 11. PMID: 37144207
Article Published Date : Apr 30, 2023
Study Type : In Vitro Study
Additional Links
Substances : Chlorella (Algae)
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Transforming growth factor beta (TGF-β) inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Extracts of Passiflora foetida inhibited the LPS-induced inflammatory and oxidative responses.Mar 11, 2018

Pubmed Data : Int J Mol Med. 2018 Mar 12. Epub 2018 Mar 12. PMID: 29532853
Article Published Date : Mar 11, 2018
Study Type : In Vitro Study
Additional Links
Substances : Passion Flower
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Fermented dried Citrus unshiu peel extracts may be a therapeutic candidate for the treatment of inflammation and dry skin.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2019 Dec ;57(1):392-402. PMID: 31188689
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Citrus Peel , Fermented Foods and Beverages, Orange: Mandarin
Diseases : Dry Skin , Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Fisetin inhibits the generation of inflammatory mediators in interleukin-1β-induced human lung epithelial cells.May 10, 2018

Pubmed Data : Int Immunopharmacol. 2018 May 11 ;60:202-210. Epub 2018 May 11. PMID: 29758489
Article Published Date : May 10, 2018
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-8 downregulation, Postaglandin PGE2 downregulation
[+]

Fisetin suppresses cigarette smoke extract-induced epithelial to mesenchymal transition of airway epithelial cells.Jan 04, 2022

Pubmed Data : Chem Biol Interact. 2022 Jan 5 ;351:109771. Epub 2021 Dec 2. PMID: 34864006
Article Published Date : Jan 04, 2022
Study Type : In Vitro Study
Additional Links
Substances : Fisetin
Diseases : Smoking
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Postaglandin PGE2 downregulation
[+]

Formononetin inhibits enterovirus 71 replication.Feb 28, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Virol J. 2015 Mar 1 ;12:35. Epub 2015 Mar 1. PMID: 25890183
Article Published Date : Feb 28, 2015
Study Type : In Vitro Study
Additional Links
Substances : Formononetin
Diseases : Coxsackievirus Infections, Enterovirus: Type 71
Pharmacological Actions : Antiviral Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Galangin as an inflammatory response modulator: An updated overview and therapeutic potential.May 31, 2023

Pubmed Data : Chem Biol Interact. 2023 Jun 1 ;378:110482. Epub 2023 Apr 10. PMID: 37044286
Article Published Date : May 31, 2023
Study Type : Review
Additional Links
Substances : Flavonoids
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Galangin prevents increased susceptibility to pentylenetetrazol-stimulated seizures by prostaglandin E2.Jan 09, 2019

Pubmed Data : Neuroscience. 2019 08 10 ;413:154-168. Epub 2019 Jun 11. PMID: 31200106
Article Published Date : Jan 09, 2019
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Inflammation, Seizures: Drug-Induced
Pharmacological Actions : Anti-Inflammatory Agents, Anticonvulsants, Postaglandin PGE2 downregulation
[+]

Genistein reduces proliferation of EP3-expressing melanoma cells through inhibition of PGE2-induced IL-8 expression.Aug 31, 2018

Pubmed Data : Int Immunopharmacol. 2018 Sep ;62:86-95. Epub 2018 Jul 5. PMID: 29990698
Article Published Date : Aug 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Genistein
Diseases : Melanoma
Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Interleukin-8 downregulation, Postaglandin PGE2 downregulation
[+]

Ginger extract may be developed as a functional food for the maintenance of gastrointestinal health.Mar 28, 2017

Pubmed Data : J Food Sci. 2017 Mar 29. Epub 2017 Mar 29. PMID: 28369951
Article Published Date : Mar 28, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ginger
Diseases : Gastrointestinal Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Ginkgetin: A natural biflavone with versatile pharmacological activities.Oct 31, 2020

Pubmed Data : Food Chem Toxicol. 2020 Nov ;145:111642. Epub 2020 Aug 9. PMID: 32783998
Article Published Date : Oct 31, 2020
Study Type : Review
Additional Links
Substances : Ginkgo biloba
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Glycyrrhizic acid facilitates anti-tumor immunity by attenuating Tregs and MDSCs: An immunotherapeutic approach.Sep 01, 2020

Pubmed Data : Int Immunopharmacol. 2020 Sep 2 ;88:106932. Epub 2020 Sep 2. PMID: 32890791
Article Published Date : Sep 01, 2020
Study Type : In Vitro Study
Additional Links
Substances : Glycyrrhizin
Diseases : Melanoma
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Postaglandin PGE2 downregulation
[+]

Green, black and rooibos tea inhibit prostaglandin E2 formation in human monocytes.Jan 07, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Jan 8 ;27(2). Epub 2022 Jan 8. PMID: 35056712
Article Published Date : Jan 07, 2022
Study Type : In Vitro Study
Additional Links
Substances : Rooibos
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Inhibitory effects of myricetin on lipopolysaccharide-induced neuroinflammation.Jan 05, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Brain Sci. 2020 Jan 6 ;10(1). Epub 2020 Jan 6. PMID: 31935983
Article Published Date : Jan 05, 2020
Study Type : In Vitro Study
Additional Links
Substances : Myricetin
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Kaempferol improves breast cancer-related depression.Nov 27, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Biosci (Landmark Ed). 2023 Nov 28 ;28(11):311. PMID: 38062826
Article Published Date : Nov 27, 2023
Study Type : In Vitro Study
Additional Links
Substances : Kaempferol
Diseases : Cancers: All, Depression, Depression: Breast Cancer Related
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

Macrophage recruitment to adipocyte and the development of obesity associated inflammation was suppressed by chia seeds.Mar 21, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Foods. 2020 Mar 22 ;9(3). Epub 2020 Mar 22. PMID: 32235695
Article Published Date : Mar 21, 2020
Study Type : In Vitro Study
Additional Links
Substances : Chia
Diseases : Inflammation, Obesity
Pharmacological Actions : Anti-Inflammatory Agents, Hypolipidemic, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Obesity Agents
[+]

Magnolol prevents ossified tendinopathy.Apr 30, 2019

Pubmed Data : Int Immunopharmacol. 2019 May ;70:117-124. Epub 2019 Feb 22. PMID: 30798160
Article Published Date : Apr 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Magnolol
Diseases : Tendon Injury
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis.Aug 31, 2012

Pubmed Data : Int Immunopharmacol. 2012 Sep ;14(1):27-31. Epub 2012 Jun 21. PMID: 22705050
Article Published Date : Aug 31, 2012
Study Type : Review
Additional Links
Substances : Peony
Diseases : Oxidative Stress, Rheumatoid Arthritis
Pharmacological Actions : Anti-Inflammatory Agents, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
Additional Keywords : Phytotherapy
[+]

Metaxalone has synergistic effect with β-caryophyllene production of inflammatory cytokines.Feb 15, 2020

Pubmed Data : Curr Mol Med. 2020 Feb 16. Epub 2020 Feb 16. PMID: 32065089
Article Published Date : Feb 15, 2020
Study Type : In Vitro Study
Additional Links
Substances : Beta-Caryophyllene
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
Additional Keywords : Natural Substance/Drug Synergy
[+]

Monoterpene glycosides with anti-inflammatory activity from Paeoniae Radix.Aug 05, 2019

Pubmed Data : Fitoterapia. 2019 Aug 6 ;138:104290. Epub 2019 Aug 6. PMID: 31398448
Article Published Date : Aug 05, 2019
Study Type : In Vitro Study
Additional Links
Substances : Peony
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Moringa oleifera alkaloids inhibited PC3 cells growth and migration.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:523962. Epub 2020 Nov 12. PMID: 33343339
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Moringa oleifera
Diseases : Prostate Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Postaglandin PGE2 downregulation
[+]

Nelumbo leaf extracts can ameliorate disease conditions involving chronic inflammation.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Res Pract. 2017 Aug ;11(4):265-274. Epub 2017 Jul 21. PMID: 28765772
Article Published Date : Jul 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Lotus
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Anti-Inflammatory Agents, Inflammation, Lotus
[+]

New lanostane-type triterpenes with anti-inflammatory activity from the epidermis of Wolfiporia cocos.Mar 28, 2022

Pubmed Data : J Agric Food Chem. 2022 Mar 29. Epub 2022 Mar 29. PMID: 35347990
Article Published Date : Mar 28, 2022
Study Type : In Vitro Study
Additional Links
Substances : Medicinal Mushrooms
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Ocimum basilicum L. seed may be useful as a dietary supplement to enhance fatty acid oxidation.Feb 17, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2022 Feb 18 ;27(4). Epub 2022 Feb 18. PMID: 35209178
Article Published Date : Feb 17, 2022
Study Type : In Vitro Study
Additional Links
Substances : Basil
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Orientin regulates COX-2/PGE-2 in A549 cell lines via miR-26b and miR-146a.Jan 26, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmaceuticals (Basel). 2022 Jan 27 ;15(2). Epub 2022 Jan 27. PMID: 35215267
Article Published Date : Jan 26, 2022
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Carcinoma: Non-Small-Cell Lung
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, MicroRNA modulator, Postaglandin PGE2 downregulation
[+]

Paeoniflorin may be a potential agent in the future treatment of osteoarthritis.Jan 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2018 Feb ;17(2):3306-3311. Epub 2017 Dec 8. PMID: 29257281
Article Published Date : Jan 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation
[+]

Paeonol suppresses neuroinflammatory responses in LPS-activated microglia cells.Nov 30, 2016

Pubmed Data : Inflammation. 2016 Dec ;39(6):1904-1917. PMID: 27624059
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Paeonol
Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation
[+]

Phloretin would be a potent agent preventing thrombosis and atherosclerosis.Mar 31, 2014

Pubmed Data : Mol Nutr Food Res. 2014 Apr ;58(4):698-708. Epub 2013 Dec 16. PMID: 24338998
Article Published Date : Mar 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Phloretin
Diseases : Atherosclerosis, Endothelial Dysfunction, Thrombosis
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation
[+]

Pine needle could be developed into functional drink to abolish the progression of inflammatory responses in various disease condition.Oct 31, 2019

Pubmed Data : J Food Biochem. 2019 Nov ;43(11):e12994. Epub 2019 Jul 28. PMID: 31659812
Article Published Date : Oct 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages, Pine Needle
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro.Nov 04, 2017

Pubmed Data : Eur J Pharmacol. 2017 Nov 5 ;814:178-186. Epub 2017 Aug 15. PMID: 28821452
Article Published Date : Nov 04, 2017
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Allergies, Klebsiella Infections
Pharmacological Actions : Anti-Allergic Agents, Cyclooxygenase 2 Inhibitors, Enzyme Inhibitors, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Plantamajoside attenuates inflammatory response in LPS-stimulated human gingival fibroblasts by inhibiting PI3K/AKT signaling pathway.Jan 31, 2019

Pubmed Data : Microb Pathog. 2019 Feb ;127:208-211. Epub 2018 Nov 23. PMID: 30476578
Article Published Date : Jan 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Plantago
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Postaglandin PGE2 downregulation
[+]

Prophylactic effect of biochanin A in lipopolysaccharide-stimulated BV2 microglial cells.May 31, 2020

Pubmed Data : Immunopharmacol Immunotoxicol. 2020 Jun 1:1-10. Epub 2020 Jun 1. PMID: 32482108
Article Published Date : May 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Biochanin A
Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Prophylactic Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Protective effects of silibinin on LPS-induced inflammation in human periodontal ligament cells.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Chem. 2022 ;10:1019663. Epub 2022 Oct 10. PMID: 36300030
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Lipopolysaccharide-Induced Toxicity, Periodontitis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Glutathione Upregulation , Interleukin-6 Downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Red clover extract has a chondroprotective effect on inflammation and may be a potential preventative agent for osteoarthritis progression.Dec 31, 2017

Pubmed Data : Cells Tissues Organs. 2018 ;206(1-2):95-105. Epub 2019 Jan 31. PMID: 30703768
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Red Clover
Diseases : Inflammation, Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Chondroprotective, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Postaglandin PGE2 downregulation
Additional Keywords : Plant Extracts
[+]

Role of apple phytochemicals, phloretin and phloridzin, in modulating processes related to intestinal inflammation.May 24, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2019 May 25 ;11(5). Epub 2019 May 25. PMID: 31130634
Article Published Date : May 24, 2019
Study Type : In Vitro Study
Additional Links
Substances : Apple, Phloretin
Diseases : Advanced Glycation End products (AGE), Gastrointestinal Inflammation
Pharmacological Actions : Anti-Glycation Agents, Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Interleukin-8 downregulation, Postaglandin PGE2 downregulation
[+]

Rutin alleviates bisphenol A-glycidyl methacrylate-induced generation of proinflammatory mediators.Nov 21, 2022

Pubmed Data : Environ Toxicol. 2022 Nov 22. Epub 2022 Nov 22. PMID: 36413001
Article Published Date : Nov 21, 2022
Study Type : In Vitro Study
Additional Links
Substances : Rutin
Diseases : Bisphenol Toxicity, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Problem Substances : Bisphenol A
[+]

Safflower yellow alleviates osteoarthritis and prevents inflammation.Oct 31, 2020

Pubmed Data : Phytomedicine. 2020 Nov ;78:153305. Epub 2020 Aug 17. PMID: 32871523
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Safflower
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

Selenium added to chokeberry juice enhances significantly its anti-inflammatory activity.Jun 13, 2015

Pubmed Data : Fitoterapia. 2015 Jun 14 ;105:73-82. Epub 2015 Jun 14. PMID: 26079445
Article Published Date : Jun 13, 2015
Study Type : In Vitro Study
Additional Links
Substances : Caffeoylquinic Acids, Chokeberry, Selenium
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Natural Substance Synergy
[+]

Sulforaphane inhibits the proliferation of synovial fibroblasts, the expression of MMPs and COX-2, and the production of PGE2, which are involved in synovitis and destruction of RA.Sep 30, 2014

Pubmed Data : Inflammation. 2014 Oct ;37(5):1496-503. PMID: 24671668
Article Published Date : Sep 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Rheumatoid Arthritis
Pharmacological Actions : Antiproliferative , Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Postaglandin PGE2 downregulation
[+]

Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis.Jan 14, 2017

Pubmed Data : Biochem Pharmacol. 2017 10 15 ;142:133-144. Epub 2017 Jul 13. PMID: 28711625
Article Published Date : Jan 14, 2017
Study Type : In Vitro Study
Additional Links
Substances : Sinomenine
Diseases : Arthritis, Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation
[+]

Tanshinone IIA attenuates Aβ-induced neurotoxicity.Nov 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biol Res (Thessalon). 2019 Dec ;26:15. Epub 2019 Nov 12. PMID: 31754613
Article Published Date : Nov 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Tanshinone IIA
Diseases : Alzheimer's Disease
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Neuroprotective Agents, Postaglandin PGE2 downregulation
[+]

Taraxasterol inhibited vascular inflammation through activating LXRα.Sep 30, 2018

Pubmed Data : Inflammation. 2018 Oct ;41(5):1755-1761. PMID: 29951871
Article Published Date : Sep 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Dandelion
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-8 downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The anti-inflammatory activity of licorice, a widely used Chinese herb.Nov 30, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharm Biol. 2017 Dec ;55(1):5-18. Epub 2016 Sep 21. PMID: 27650551
Article Published Date : Nov 30, 2017
Study Type : Review
Additional Links
Substances : Licorice
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Phytotherapy, Plant Extracts
[+]

These findings provide the evidence to develop oleuropein as a potential therapeutic agent for patients with osteoarthritis.Oct 17, 2017

Pubmed Data : Food Funct. 2017 Oct 18 ;8(10):3737-3744. PMID: 28952621
Article Published Date : Oct 17, 2017
Study Type : In Vitro Study
Additional Links
Substances : Oleuropein
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation
[+]

These results indicate that compounds from Piper nigrum have potential anti-inflammatory effects.Feb 06, 2020

Pubmed Data : J Agric Food Chem. 2020 Feb 7. Epub 2020 Feb 7. PMID: 32031370
Article Published Date : Feb 06, 2020
Study Type : In Vitro Study
Additional Links
Substances : Black Pepper
Diseases : Inflammation
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

These results suggest that asiatic acid inhibited of iNOS, COX-2, IL-6, IL-1 beta, and TNF-alpha expressions.Feb 29, 2008

Pubmed Data : Int Immunopharmacol. 2008 Mar ;8(3):431-41. Epub 2007 Dec 3. PMID: 18279797
Article Published Date : Feb 29, 2008
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

This study supports the potential neuroprotective effects of maple syrup extracts.Jul 13, 2016

Pubmed Data : Neurochem Res. 2016 Jul 14. Epub 2016 Jul 14. PMID: 27418278
Article Published Date : Jul 13, 2016
Study Type : In Vitro Study
Additional Links
Substances : Maple Syrup
Diseases : Alzheimer's Disease, Brain Inflammation , Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Neuroprotective Agents, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Plant Extracts
[+]

Thymoquinone suppresses migration of human renal carcinoma caki-1 cells.Aug 25, 2020

Pubmed Data : Biomol Ther (Seoul). 2020 Aug 26. Epub 2020 Aug 26. PMID: 32843585
Article Published Date : Aug 25, 2020
Study Type : In Vitro Study
Additional Links
Substances : Thymoquinone
Diseases : Kidney Cancer
Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Matrix metalloproteinase-9 (MMP-9) inhibitor, Postaglandin PGE2 downregulation
[+]

Tricetin protects rat chondrocytes against IL-1β-Induced inflammation and apoptosis.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oxid Med Cell Longev. 2019 ;2019:4695381. Epub 2019 Apr 28. PMID: 31231454
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Inflammation
Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Chondroprotective, Interleukin-1 beta downregulation, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Postaglandin PGE2 downregulation
[+]

Would carvacrol be a supporting treatment option effective in minimizing the deleterious effects of COVID-19?Oct 19, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2021 Oct 20. Epub 2021 Oct 20. PMID: 34669001
Article Published Date : Oct 19, 2021
Study Type : Review
Additional Links
Substances : Carvacrol
Diseases : Coronavirus Infection
Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta upregulation, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Xanthohumol attenuated inflammation and ECM degradation by mediating HO-1/C/EBPβ pathway in osteoarthritis chondrocytes.Dec 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2021 ;12:680585. Epub 2021 May 4. PMID: 34017261
Article Published Date : Dec 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Xanthohumol
Diseases : Osteoarthritis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Postaglandin PGE2 downregulation , Tumor Necrosis Factor (TNF) Alpha Inhibitor

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