Prostaglandin PGE2 downregulation

Name	AC	CK
Curcumin	13	25
Phloretin	4	18
Turmeric	3	12
Bromelain	1	10
Soup	1	10
Tart Cherry	1	10
Vitamin C	1	10
Dandelion	4	6
Ginsenosides	1	5
Melatonin	1	5
Berberine	2	4
Cannabidiol	2	4
Cannabis	2	4
Pomegranate	2	3
Sesamol	2	3
Angelica	1	2
Billygoat Weed	1	2
Boswellia	1	2
Fisetin	1	2
Gingerol	2	2
Ginseng (Siberian)	1	2
Justicia gendarussa	1	2
L-Carnitine	1	2
Lignans	1	2
Moringa oleifera	2	2
NAC (N-acetyl-L-cysteine)	1	2
Olive Oil	1	2
Patchouli	1	2
Piceatannol	1	2
Polyunsaturated Fatty Acids (PUFAs)	1	2
Rose	1	2
Rosemary	1	2
Rosmarinic acid	1	2
Sulforaphane	1	2
Thymoquinone	1	2
Triphala	1	2
Whey	1	2
Wormwood	2	2
6-Shogaol	1	1
Artemisinin	1	1
Astaxanthin	1	1
Avacado	1	1
Biochanin A	1	1
Burdock	1	1
Capsaicin	1	1
Chlorella (Algae)	1	1
Choline	1	1
Chrysanthemum Indicum	1	1
Citrus Peel	1	1
Cucurbitacin B	1	1
Curcumin: Lipidated	1	1
Echinacea	1	1
Ellagic Acid	1	1
Flavonoids	1	1
Frankincense	1	1
Fruit: All	1	1
Gallic Acid	1	1
Hesperidin	1	1
Horseradish	1	1
Isothiocyanates	1	1
Kimchi	1	1
Lion's Mane (Hericium Erinaceus)	1	1
Mistletoe	1	1
Mussel: Green-lipped (Perna canaliculus)	1	1
Myricetin	1	1
Nexrutine (Phellodendrom)	1	1
Nobiletin	1	1
Oranges	1	1
Piperine	1	1
Prunella vulgaris	1	1
Punicalagin	1	1
Purple Carrots	1	1
Rice Bran	1	1
Salicylic acid	1	1
Spikenard	1	1
Vegetables: All	1	1
Wasabi	1	1
Xanthones	1	1

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Pubmed Data : J Ethnopharmacol. 2016 Apr 21. Epub 2016 Apr 21. PMID: 27109342

Article Published Date : Apr 20, 2016

Study Type : Animal Study

Additional Links

Substances : Dandelion

Diseases : Arthritis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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The flower extract of Rosa rugosa may be a beneficial anti-inflammatory agent.Feb 29, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomol Ther (Seoul). 2016 Mar 1 ;24(2):184-90. PMID: 26797110

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Rose

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

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Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Korean J Physiol Pharmacol. 2015 Jan ;19(1):21-7. Epub 2014 Dec 31. PMID: 25605993

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Wormwood

Diseases : Dental Diseases, Inflammation, Periodontal Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial, Antioxidants, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Prostaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

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Arthrocen could potentially bring about the reduced pain produced by COX‐2 inhibitors without the known side effects of COX‐2 inhibition.Jan 31, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2017 Jan 14 ;17(1):47. Epub 2017 Jan 14. PMID: 28088220

Article Published Date : Jan 13, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ellagic Acid, Gallic Acid, Pomegranate, Punicalagin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation

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Fermented Arctium lappa fruit extract had an inhibitory effect on the IgE-mediated allergic response in RBL‑2H3 cells.Dec 27, 2015

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Pubmed Data : Int J Mol Med. 2015 Dec 28. Epub 2015 Dec 28. PMID: 26707911

M. oleifera flower extract can be a potent inhibitor of inflammation through NF-κB signaling pathway. Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mediators Inflamm. 2015 ;2015:720171. Epub 2015 Nov 2. PMID: 26609199

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Moringa oleifera

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

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Nexrutine treatment inhibited growth of pancreatic cancer cells through induction of apoptosis.Feb 28, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:413237. Epub 2013 Oct 8. PMID: 24223056

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Chrysanthemum Indicum

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Prostaglandin PGE2 downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response

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The citrus flavone nobiletin has beneficial actions of reducing pro-inflammatory and pro-labour mediators in the presence of bacterial endotoxin lipopolysaccharide.Dec 31, 2013

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View the Evidence: 89 Abstracts with Prostaglandin PGE2 downregulation Research

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Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

Cherry juice increased sleep time and sleep efficiency. Mar 26, 2017

Consumption of the vegetable soup decreases oxidative stress and biomarkers of inflammation, which indicates that the protective effect of vegetables may extend beyond their antioxidant capacity.Oct 31, 2004

Dosage Study: A daily dose of 3.6 g of curcumin engendered 62% and 57% decreases in inducible PGE(2) production in blood samples taken 1 hour after dose on days 1 and 29, respectively, in patients with advanced colorectal cancer.Oct 15, 2004

Gazpacho soup consumption significantly increases plasma concentrations of vitamin C and significantly decreases 8-epi-PGF2alpha, PGE2 and MCP-1 concentrations in healthy humansFeb 28, 2006

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

Turmeric gel can be effectively used as an adjunct to mechanical plaque control in the prevention of plaque and gingivitis.Dec 31, 2014

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

An extract of polymethoxyflavones from Billygoat weed exhibited significant antinociceptive and anti-inflammatory effects.Sep 11, 2016

An immune-modulating diet in combination with chemotherapy prevented cancer cachexia without suppressing chemotherapeutic efficacy.Jul 01, 2015

Berberine suppresses growth and metastasis of endometrial cancer cells.Jun 30, 2018

Boswellia's anti-inflammatory activity is due in part to its inhibition of prostaglandin E2 synthesis.Jan 01, 2011

Curcumin and NAC prevent fatty acid changes produced by ethanol and also reduce the inflammatory response of ethanol by reducing the level of prostaglandins.Mar 01, 2005

Curcumin has therapeutic effects in chemically-induced colitis. Jun 28, 2006

Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats.Aug 01, 2006

Extra virgin olive oil is a beneficial functional food exerting a preventive/palliative role in the management of systemic lupus erythematosus.Dec 31, 2015

Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.Dec 21, 2016

Fisetin may be a potential agent in the treatment of osteoarthritis.Feb 13, 2017

L‑carnitine ameliorated liver inflammation and serum pro‑inflammatory markers in cancer cachexia.Dec 03, 2015

Oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia.Feb 29, 2004

Phloretin may be a potential agent for the treatment of osteoarthritis.Nov 22, 2017

Piceatannol may be a potential therapeutic agent for osteoarthritis.Nov 14, 2017

Polysaccharides from Acanthopanax senticosus enhances intestinal integrity in lipopolysaccharide-challenged mice.Jul 31, 2016

Pomegranate extract is abundant in hydrolysable tannins that display multiple anti-acne capacities.Jan 11, 2017

Sesame lignans inhibit delta-5 desaturase activity, increasing dihomo-gamma-linoleic acid levels and decreasing prostaglandin E2 synthesis.Mar 01, 1998

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells.Feb 28, 2014

Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.Dec 31, 2015

Taraxasterol has the potential protective effect against Freund's complete adjuvant induced arthritis in rats.Apr 20, 2016

The flower extract of Rosa rugosa may be a beneficial anti-inflammatory agent.Feb 29, 2016

The present investigation provides pharmacological evidence to support the folklore claim that J. gendarussa is an anti-inflammatory agent.Jun 30, 2011

The results indicate a potential for therapeutic use of cannabidiol in chronic painful states.Feb 04, 2007

Thymoquinone inhibits LoVo cancer cell growth and migration.Feb 20, 2017

Treatment with taraxasterol significantly increased the pain thresholds and reduced the clinical arthritic scores of mice.Nov 30, 2016

Triphala has a promising anti-inflammatory effect in the inflamed paw of arthritis-induced rats.Dec 31, 2014

Volatile oil of Angelica sinensis roots could significantly inhibit the release of PGE2, HIS, 5-HT and TNF-α.Sep 14, 2016

β-patchoulene isolated from patchouli oil had Anti-inflammatory activity.Apr 13, 2016

ω-3 polyunsaturated fatty acids had inhibitory effects on endometrial cancer development.Dec 31, 2014

6-gingerol has potential use in treating inflammatory bone destruction associated with excessive prostaglandin E2 production.Jul 15, 2018

6-shogaol and curcumin might be effective on GSK3β pathway via lowering PGE2 levels.Oct 24, 2016

A hexane fraction of P. vulgaris var. lilacina may be a potent anti-inflammatory candidate.Dec 31, 2012

An extract of A. annua was shown to be a potent inhibitor of TNF-α and a strong inhibitor of PGE2 production in activated neutrophils.Dec 31, 2014

Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.Dec 31, 2014

Arthrocen could potentially bring about the reduced pain produced by COX‐2 inhibitors without the known side effects of COX‐2 inhibition.Jan 31, 2017

Astaxanthin attenuates the UVB-induced secretion of prostaglandin E(2) and interleukin-8, indicating its possible role in minimizing inflammation associated with skin damage.Jul 01, 2012

B. serrata extract inhibits proliferation, angiogenesis and migration and induces apoptosis in HT-29 cellsMay 23, 2017

Biochanin A is an attractive compound for preventing 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced wasting syndrome.Dec 31, 2018

C. longa and curcumin might decrease the risk of cancer and other malignant diseases in the reproductive system. Oct 25, 2017

C. vulgaris possesses significant anti-inflammatory activity and could be a potential anti-inflammatory agent of natural origin.Mar 31, 2016

Celecoxib and curcumin work synergistically to inhibit the growth of colorectal cancer cells.Sep 15, 2005

Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.Nov 25, 2019

Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects.Dec 31, 2014

Curcumin inhibits human pancreatic cancer cell growth. Nov 15, 2004

Curcumin inhibits lipopolysaccharide-induced inflammation. Jul 01, 2010

Curcumin may be a promising pharmacological candidate for neurodegenerative diseases.Dec 31, 2015

Curcumin significantly decreased the LPS-induced pro-inflammatory mediators NO, PGE2, and IL-6 by inhibiting the activation of NF-κB.Jun 30, 2015

Dandelion leaves have an anti-inflammatory effect on lipopolysaccharide-induced inflammation. Aug 01, 2010

Desoxo-narchinol-A isolated from Nardostachys jatamansi exhibits protective effects against LPS-induced endotoxin shock and inflammation.Nov 30, 2015

Dietary interventions to increase the dihomo-gamma-linoleic acid to arachidonic acid ratio may not necessarily decrease PGE2 synthesis in tissues where COX-1 enzymes predominate over COX-2.Jul 15, 2002

Dietary omega-3 fatty acids, curcumin and capsaicin lower the release of lysosomal enzymes and eicosanoids in rat peritoneal macrophages associated with inflammation. Jan 01, 2000

Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cells.Aug 24, 2007

Ellagic acid, gallic acid and punicalagin may be the compounds responsible for the anti-inflammatory potential of P. granatum.Jan 13, 2017

Fermented Arctium lappa fruit extract had an inhibitory effect on the IgE-mediated allergic response in RBL‑2H3 cells.Dec 27, 2015

HDMPPA may exert anti-inflammatory responses by suppressing LPS-induced expression of proinflammatory mediators and cytokines.May 31, 2015

Hesperidin may be a potential agent for the treatment of osteoarthritis.Sep 30, 2018

Immunomodulatory effect of curcumin on lipopolysaccharide- and/or flagellin-induced production of prostaglandin E2 and relative expression of proinflammatory cytokines.May 31, 2019

Lion's mane suppresses LPS-induced pro-inflammation gene activation in macrophages.Nov 29, 2011

M. oleifera extracts suppressed the expression of inflammatory mediators in LPS stimulated macrophages.Sep 30, 2015

M. oleifera flower extract can be a potent inhibitor of inflammation through NF-κB signaling pathway. Dec 31, 2014

Nexrutine treatment inhibited growth of pancreatic cancer cells through induction of apoptosis.Feb 28, 2014

Prostaglandin PGE2 downregulation

View the Evidence:
89 Abstracts with Prostaglandin PGE2 downregulation Research