Prostaglandin PGE2 downregulation

Name	AC	CK
Curcumin	13	25
Phloretin	4	18
Turmeric	3	12
Bromelain	1	10
Soup	1	10
Tart Cherry	1	10
Vitamin C	1	10
Dandelion	4	6
Ginsenosides	1	5
Melatonin	1	5
Berberine	2	4
Cannabidiol	2	4
Cannabis	2	4
Pomegranate	2	3
Sesamol	2	3
Angelica	1	2
Billygoat Weed	1	2
Boswellia	1	2
Fisetin	1	2
Gingerol	2	2
Ginseng (Siberian)	1	2
Justicia gendarussa	1	2
L-Carnitine	1	2
Lignans	1	2
Moringa oleifera	2	2
NAC (N-acetyl-L-cysteine)	1	2
Olive Oil	1	2
Patchouli	1	2
Piceatannol	1	2
Polyunsaturated Fatty Acids (PUFAs)	1	2
Rose	1	2
Rosemary	1	2
Rosmarinic acid	1	2
Sulforaphane	1	2
Thymoquinone	1	2
Triphala	1	2
Whey	1	2
Wormwood	2	2
6-Shogaol	1	1
Artemisinin	1	1
Astaxanthin	1	1
Avacado	1	1
Biochanin A	1	1
Burdock	1	1
Capsaicin	1	1
Chlorella (Algae)	1	1
Choline	1	1
Chrysanthemum Indicum	1	1
Citrus Peel	1	1
Cucurbitacin B	1	1
Curcumin: Lipidated	1	1
Echinacea	1	1
Ellagic Acid	1	1
Flavonoids	1	1
Frankincense	1	1
Fruit: All	1	1
Gallic Acid	1	1
Hesperidin	1	1
Horseradish	1	1
Isothiocyanates	1	1
Kimchi	1	1
Lion's Mane (Hericium Erinaceus)	1	1
Mistletoe	1	1
Mussel: Green-lipped (Perna canaliculus)	1	1
Myricetin	1	1
Nexrutine (Phellodendrom)	1	1
Nobiletin	1	1
Oranges	1	1
Piperine	1	1
Prunella vulgaris	1	1
Punicalagin	1	1
Purple Carrots	1	1
Rice Bran	1	1
Salicylic acid	1	1
Spikenard	1	1
Vegetables: All	1	1
Wasabi	1	1

[+]

Cherry juice increased sleep time and sleep efficiency. Mar 26, 2017

Click here to read the entire abstract

Pubmed Data : Am J Ther. 2017 Mar 27. Epub 2017 Mar 27. PMID: 28901958

Article Published Date : Mar 26, 2017

Study Type : Human In Vitro, Human Study

Additional Links

Substances : Tart Cherry

Diseases : Insomnia

Pharmacological Actions : Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation

[+]

Consumption of the vegetable soup decreases oxidative stress and biomarkers of inflammation, which indicates that the protective effect of vegetables may extend beyond their antioxidant capacity.Oct 31, 2004

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Nutr. 2004 Nov ;134(11):3021-5. PMID: 15514269

Article Published Date : Oct 31, 2004

Study Type : Human Study

Additional Links

Substances : Soup, Vitamin C

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Antioxidants, Monocyte chemotattractant protein-1 (MCP-1) Inhibitor, Prostaglandin PGE2 downregulation

Additional Keywords : Bioavailability

[+]

Dosage Study: A daily dose of 3.6 g of curcumin engendered 62% and 57% decreases in inducible PGE(2) production in blood samples taken 1 hour after dose on days 1 and 29, respectively, in patients with advanced colorectal cancer.Oct 15, 2004

Click here to read the entire abstract

Pubmed Data : Clin Cancer Res. 2004 Oct 15;10(20):6847-54. PMID: 15501961

Article Published Date : Oct 15, 2004

Study Type : Human Study

Additional Links

Substances : Curcumin

Diseases : Colorectal Cancer

Pharmacological Actions : Antineoplastic Agents, Prostaglandin PGE2 downregulation

[+]

Gazpacho soup consumption significantly increases plasma concentrations of vitamin C and significantly decreases 8-epi-PGF2alpha, PGE2 and MCP-1 concentrations in healthy humansFeb 28, 2006

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Pubmed Data : J Nutr Biochem. 2006 Mar ;17(3):183-9. Epub 2005 Aug 15. PMID: 16169205

Article Published Date : Feb 28, 2006

Study Type : Human Study

Additional Links

Pharmacological Actions : Monocyte chemotattractant protein-1 (MCP-1) Inhibitor, Prostaglandin PGE2 downregulation, Vasodilator Agents

Additional Keywords : Bioavailability

[+]

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

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Pubmed Data : Int J Cosmet Sci. 2016 Feb ;38(1):85-92. Epub 2015 Aug 30. PMID: 26212527

Article Published Date : Jan 31, 2016

Study Type : Human In Vitro, Human Study

Additional Links

Substances : Phloretin

Diseases : Acne

Pharmacological Actions : Anti-Bacterial Agents, Antimicrobial, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

[+]

Turmeric gel can be effectively used as an adjunct to mechanical plaque control in the prevention of plaque and gingivitis.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Natl J Maxillofac Surg. 2015 Jan-Jun;6(1):67-71. PMID: 26668456

Article Published Date : Dec 31, 2014

Study Type : Human Study

Additional Links

Substances : Turmeric

Diseases : Dental Plaque, Gingivitis

Pharmacological Actions : Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation

[+]

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2017 Mar 10 ;9(3). Epub 2017 Mar 10. PMID: 28287423

Article Published Date : Mar 09, 2017

Study Type : Animal Study, Human In Vitro

Additional Links

Substances : Ginsenosides

Diseases : Osteoarthritis

Pharmacological Actions : Chondroprotective, Cyclooxygenase 2 Inhibitors, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Prostaglandin PGE2 downregulation

[+]

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

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Pubmed Data : J Pineal Res. 2012 Sep ;53(2):154-65. Epub 2012 Feb 21. PMID: 22348531

Article Published Date : Aug 31, 2012

Study Type : Human In Vitro

Additional Links

Substances : Melatonin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response

[+]

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Click here to read the entire abstract

Pubmed Data : Food Funct. 2015 Jun ;6(6):1960-7. PMID: 25996641

Article Published Date : May 31, 2015

Study Type : Human In Vitro

Additional Links

Substances : Phloretin

Diseases : Experimental Lung Inflammation

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Prostaglandin PGE2 downregulation

[+]

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(5):e0123478. Epub 2015 May 8. PMID: 25954974

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Colorectal Cancer

Pharmacological Actions : Anti-metastatic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Prostaglandin PGE2 downregulation

[+]

An extract of polymethoxyflavones from Billygoat weed exhibited significant antinociceptive and anti-inflammatory effects.Sep 11, 2016

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2016 Sep 12. Epub 2016 Sep 12. PMID: 27633406

Article Published Date : Sep 11, 2016

Study Type : Animal Study

Additional Links

Substances : Billygoat Weed

Diseases : Inflammation, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antinoceceptive , Interleukin-1 beta downregulation, Prostaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

[+]

An immune-modulating diet in combination with chemotherapy prevented cancer cachexia without suppressing chemotherapeutic efficacy.Jul 01, 2015

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Pubmed Data : Nutr Cancer. 2015 Jul 2:1-9. Epub 2015 Jul 2. PMID: 26133950

Article Published Date : Jul 01, 2015

Study Type : Animal Study

Additional Links

Substances : Whey

Diseases : Cachexia: Cancer

Pharmacological Actions : Anti-Cachexic Agents, Chemotherapeutic, Interleukin-6 Downregulation, Prostaglandin PGE2 downregulation, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Drug: 5-flourouracil

[+]

Berberine suppresses growth and metastasis of endometrial cancer cells.Jun 30, 2018

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:1287-1293. Epub 2018 May 7. PMID: 29864910

Article Published Date : Jun 30, 2018

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Berberine

Diseases : Endometrial Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

[+]

Boswellia's anti-inflammatory activity is due in part to its inhibition of prostaglandin E2 synthesis.Jan 01, 2011

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Pubmed Data : Br J Pharmacol. 2011 Jan;162(1):147-62. PMID: 20840544

Article Published Date : Jan 01, 2011

Study Type : Animal Study

Additional Links

Substances : Boswellia

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Prostaglandin Antagonists, Prostaglandin PGE2 downregulation

[+]

Curcumin and NAC prevent fatty acid changes produced by ethanol and also reduce the inflammatory response of ethanol by reducing the level of prostaglandins.Mar 01, 2005

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Pubmed Data : Pain. 2005 Mar;114(1-2):266-77. Epub 2005 Jan 26. PMID: 11504446

Article Published Date : Mar 01, 2005

Study Type : Animal Study

Additional Links

Substances : Curcumin, NAC (N-acetyl-L-cysteine)

Diseases : Alcohol Toxicity

Pharmacological Actions : Antioxidants, Enzyme Inhibitors, Hepatoprotective, Prostaglandin PGE2 downregulation

[+]

Curcumin has therapeutic effects in chemically-induced colitis. Jun 28, 2006

Click here to read the entire abstract

Pubmed Data : World J Gastroenterol. 2006 Jun 28;12(24):3848-53. PMID: 16804969

Article Published Date : Jun 28, 2006

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Colitis

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats.Aug 01, 2006

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Pubmed Data : Int Immunopharmacol. 2006 Aug;6(8):1233-42. Epub 2006 Apr 7. PMID: 16782535

Article Published Date : Aug 01, 2006

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Colitis

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation

[+]

Extra virgin olive oil is a beneficial functional food exerting a preventive/palliative role in the management of systemic lupus erythematosus.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : J Nutr Biochem. 2016 Jan ;27:278-88. Epub 2015 Oct 29. PMID: 26525667

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Olive Oil

Diseases : Systemic Lupus Erythematosus

Pharmacological Actions : Anti-Inflammatory Agents, Matrix metalloproteinase-3 (MMP-3) inhibitor, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation, Renoprotective

[+]

Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.Dec 21, 2016

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Pubmed Data : Biomed Pharmacother. 2016 Dec 22 ;86:441-449. Epub 2016 Dec 22. PMID: 28012923

Article Published Date : Dec 21, 2016

Study Type : Animal Study

Additional Links

Substances : Rosemary, Rosmarinic acid

Diseases : Brain Inflammation , Neuropathic Pain

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

[+]

Fisetin may be a potential agent in the treatment of osteoarthritis.Feb 13, 2017

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2017 Feb 14 ;45:135-147. Epub 2017 Feb 14. PMID: 28213268

Article Published Date : Feb 13, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

L‑carnitine ameliorated liver inflammation and serum pro‑inflammatory markers in cancer cachexia.Dec 03, 2015

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Pubmed Data : Mol Med Rep. 2015 Dec 4. Epub 2015 Dec 4. PMID: 26647854

Article Published Date : Dec 03, 2015

Study Type : Animal Study

Additional Links

Substances : L-Carnitine

Diseases : Cachexia: Cancer, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia.Feb 29, 2004

Click here to read the entire abstract

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2004 Mar ;369(3):294-9. Epub 2004 Feb 12. PMID: 14963641

Article Published Date : Feb 29, 2004

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabis

Diseases : Hyperalgesia, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

[+]

Phloretin may be a potential agent for the treatment of osteoarthritis.Nov 22, 2017

Click here to read the entire abstract

Pubmed Data : Food Funct. 2017 Nov 23. Epub 2017 Nov 23. PMID: 29168867

Article Published Date : Nov 22, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Phloretin

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Piceatannol may be a potential therapeutic agent for osteoarthritis.Nov 14, 2017

Click here to read the entire abstract

Pubmed Data : Food Funct. 2017 Nov 15 ;8(11):3926-3937. PMID: 28933476

Article Published Date : Nov 14, 2017

Study Type : Animal Study

Additional Links

Substances : Piceatannol

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Heme oxygenase-1 inducer, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nrf2 activation, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Polysaccharides from Acanthopanax senticosus enhances intestinal integrity in lipopolysaccharide-challenged mice.Jul 31, 2016

Click here to read the entire abstract

Pubmed Data : Anim Sci J. 2016 Aug ;87(8):1011-8. Epub 2015 Oct 5. PMID: 26435041

Article Published Date : Jul 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginseng (Siberian)

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Gastroprotective, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Polysaccharides

[+]

Pomegranate extract is abundant in hydrolysable tannins that display multiple anti-acne capacities.Jan 11, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2017 Jan 12 ;18(1). Epub 2017 Jan 12. PMID: 28085116

Article Published Date : Jan 11, 2017

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Acne

Pharmacological Actions : Anti-Bacterial Agents, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

[+]

Sesame lignans inhibit delta-5 desaturase activity, increasing dihomo-gamma-linoleic acid levels and decreasing prostaglandin E2 synthesis.Mar 01, 1998

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Pubmed Data : Prostaglandins Leukot Essent Fatty Acids. 1998 Mar ;58(3):185-91. PMID: 9610840

Article Published Date : Mar 01, 1998

Study Type : Animal Study

Additional Links

Substances : Lignans

Pharmacological Actions : Prostaglandin PGE2 downregulation

Additional Keywords : Anti-Inflammatory Agents, arachidonic acid, Gamma-Linoleic Acid GLA, Inflammation, Prostaglandin E2

[+]

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells.Feb 28, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Biochem Nutr. 2014 Mar ;54(2):95-101. Epub 2014 Feb 19. PMID: 24688218

Article Published Date : Feb 28, 2014

Study Type : Animal Study

Additional Links

Substances : Sesamol

Diseases : Colon Cancer

Pharmacological Actions : Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

[+]

Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Int J Mol Med. 2016 Jan ;37(1):182-8. Epub 2015 Oct 27. PMID: 26531002

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Sulforaphane

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-E2-Related Factor-2 (Nrf2) Modulator, Prostaglandin PGE2 downregulation

[+]

Taraxasterol has the potential protective effect against Freund's complete adjuvant induced arthritis in rats.Apr 20, 2016

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2016 Apr 21. Epub 2016 Apr 21. PMID: 27109342

Article Published Date : Apr 20, 2016

Study Type : Animal Study

Additional Links

Substances : Dandelion

Diseases : Arthritis, Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

The flower extract of Rosa rugosa may be a beneficial anti-inflammatory agent.Feb 29, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biomol Ther (Seoul). 2016 Mar 1 ;24(2):184-90. PMID: 26797110

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Rose

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

The present investigation provides pharmacological evidence to support the folklore claim that J. gendarussa is an anti-inflammatory agent.Jun 30, 2011

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Pubmed Data : J Nat Med. 2011 Jul ;65(3-4):471-9. Epub 2011 Mar 17. PMID: 21416126

Article Published Date : Jun 30, 2011

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Justicia gendarussa

Diseases : Inflammation

Pharmacological Actions : 15-Lipoxygenase (15-LOX) Inhibitor, 5-Lipoxygenase Inhibitor, Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Prostaglandin PGE2 downregulation

Additional Keywords : Folk Medicine, Plant Extracts

[+]

The results indicate a potential for therapeutic use of cannabidiol in chronic painful states.Feb 04, 2007

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Pubmed Data : Eur J Pharmacol. 2007 Feb 5 ;556(1-3):75-83. Epub 2006 Nov 10. PMID: 17157290

Article Published Date : Feb 04, 2007

Study Type : Animal Study

Additional Links

Substances : Cannabidiol, Cannabis

Diseases : Hyperalgesia, Inflammation, Neuropathic Pain

Pharmacological Actions : NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Thymoquinone inhibits LoVo cancer cell growth and migration.Feb 20, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : World J Gastroenterol. 2017 Feb 21 ;23(7):1171-1179. PMID: 28275297

Article Published Date : Feb 20, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Thymoquinone

Diseases : Colon Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Anti-metastatic, Antiproliferative , Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

Additional Keywords : Dose Response

[+]

Treatment with taraxasterol significantly increased the pain thresholds and reduced the clinical arthritic scores of mice.Nov 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2016 Dec ;12(6):4035-4040. Epub 2016 Nov 2. PMID: 28101182

Article Published Date : Nov 30, 2016

Study Type : Animal Study

Additional Links

Substances : Dandelion

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Triphala has a promising anti-inflammatory effect in the inflamed paw of arthritis-induced rats.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Pharm Biol. 2015 Jan ;53(1):51-60. Epub 2014 Oct 7. PMID: 25289531

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Triphala

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

Volatile oil of Angelica sinensis roots could significantly inhibit the release of PGE2, HIS, 5-HT and TNF-α.Sep 14, 2016

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2016 Sep 15 ;191:195-205. Epub 2016 Aug 9. PMID: 27292195

Article Published Date : Sep 14, 2016

Study Type : Animal Study

Additional Links

Substances : Angelica

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Roots, Volatile Oil Compounds

[+]

β-patchoulene isolated from patchouli oil had Anti-inflammatory activity.Apr 13, 2016

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2016 Apr 14. Epub 2016 Apr 14. PMID: 27090925

Article Published Date : Apr 13, 2016

Study Type : Animal Study

Additional Links

Substances : Patchouli

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response, Plant Oils

[+]

ω-3 polyunsaturated fatty acids had inhibitory effects on endometrial cancer development.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2015;5:14958. Epub 2015 Oct 15. PMID: 26468779

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Polyunsaturated Fatty Acids (PUFAs)

Diseases : Endometrial Cancer

Pharmacological Actions : Anticarcinogenic Agents, Chemopreventive, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

Additional Keywords : Risk Reduction

[+]

6-gingerol has potential use in treating inflammatory bone destruction associated with excessive prostaglandin E2 production.Jul 15, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2018 Jul 16 ;19(7). Epub 2018 Jul 16. PMID: 30013004

Article Published Date : Jul 15, 2018

Study Type : In Vitro Study

Additional Links

Substances : Gingerol

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation

[+]

6-shogaol and curcumin might be effective on GSK3β pathway via lowering PGE2 levels.Oct 24, 2016

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Pubmed Data : Chem Biol Interact. 2016 Oct 25 ;258:257-65. Epub 2016 Aug 16. PMID: 27645308

Article Published Date : Oct 24, 2016

Study Type : In Vitro Study

Additional Links

Substances : 6-Shogaol, Curcumin, Gingerol

Diseases : Lung Cancer

Pharmacological Actions : Antiproliferative , Prostaglandin PGE2 downregulation

[+]

A hexane fraction of P. vulgaris var. lilacina may be a potent anti-inflammatory candidate.Dec 31, 2012

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2013 ;14(11):21489-503. Epub 2013 Oct 30. PMID: 24177568

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Prunella vulgaris

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

[+]

An extract of A. annua was shown to be a potent inhibitor of TNF-α and a strong inhibitor of PGE2 production in activated neutrophils.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Inflamm Res. 2015 ;8:9-14. Epub 2015 Jan 14. PMID: 25609991

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Artemisinin, Wormwood

Diseases : Inflammation

Pharmacological Actions : Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response, Plant Extracts

[+]

Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Korean J Physiol Pharmacol. 2015 Jan ;19(1):21-7. Epub 2014 Dec 31. PMID: 25605993

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Wormwood

Diseases : Dental Diseases, Inflammation, Periodontal Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Antimicrobial, Antioxidants, Interleukin-10 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Prostaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

[+]

Arthrocen could potentially bring about the reduced pain produced by COX‐2 inhibitors without the known side effects of COX‐2 inhibition.Jan 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : FEBS Open Bio. 2017 Feb ;7(2):187-194. Epub 2017 Jan 9. PMID: 28174685

Article Published Date : Jan 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Avacado

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

[+]

Astaxanthin attenuates the UVB-induced secretion of prostaglandin E(2) and interleukin-8, indicating its possible role in minimizing inflammation associated with skin damage.Jul 01, 2012

Click here to read the entire abstract

Pubmed Data : Exp Dermatol. 2012 Jul ;21 Suppl 1:11-7. PMID: 22626465

Article Published Date : Jul 01, 2012

Study Type : In Vitro Study

Additional Links

Substances : Astaxanthin

Diseases : Skin Diseases: Photo-Aging, Sunburn

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-8 downregulation, Prostaglandin PGE2 downregulation

[+]

B. serrata extract inhibits proliferation, angiogenesis and migration and induces apoptosis in HT-29 cellsMay 23, 2017

Click here to read the entire abstract

Pubmed Data : Prostaglandins Other Lipid Mediat. 2017 May 24 ;131:1-8. Epub 2017 May 24. PMID: 28549801

Article Published Date : May 23, 2017

Study Type : In Vitro Study

Additional Links

Substances : Frankincense

Diseases : Colon Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic, Matrix metalloproteinase-2 (MMP-2) inhibitor, Matrix metalloproteinase-9 (MMP-9) inhibitor, Prostaglandin PGE2 downregulation, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Plant Extracts

[+]

Biochanin A is an attractive compound for preventing 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced wasting syndrome.Dec 31, 2018

Click here to read the entire abstract

Pubmed Data : J Environ Sci Health A Tox Hazard Subst Environ Eng. 2019 ;54(9):865-873. Epub 2019 Apr 20. PMID: 31007129

Article Published Date : Dec 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Biochanin A

Diseases : Chronic Wasting Disease

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 1 Inhibitor, Prostaglandin PGE2 downregulation

[+]

C. longa and curcumin might decrease the risk of cancer and other malignant diseases in the reproductive system. Oct 25, 2017

Click here to read the entire abstract

Pubmed Data : Endocr Regul. 2017 Oct 26 ;51(4):220-228. PMID: 29232190

Article Published Date : Oct 25, 2017

Study Type : Review

Additional Links

Substances : Curcumin, Turmeric

Diseases : Ovarian Cancer, Prostate Cancer, Testicular Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Apoptotic, Matrix metalloproteinase-9 (MMP-9) inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

[+]

C. vulgaris possesses significant anti-inflammatory activity and could be a potential anti-inflammatory agent of natural origin.Mar 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacognosy Res. 2016 Apr-Jun;8(2):118-22. PMID: 27034602

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Chlorella (Algae)

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Celecoxib and curcumin work synergistically to inhibit the growth of colorectal cancer cells.Sep 15, 2005

Click here to read the entire abstract

Pubmed Data : Clin Cancer Res. 2005 Sep 15;11(18):6738-44. PMID: 16166455

Article Published Date : Sep 15, 2005

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Colon Cancer, Colorectal Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Prostaglandin PGE2 downregulation

Additional Keywords : Drug: Celecoxib, Drug Synergy

[+]

Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.Nov 25, 2019

Click here to read the entire abstract

Pubmed Data : Brain Res. 2019 Nov 26:146567. Epub 2019 Nov 26. PMID: 31783002

Article Published Date : Nov 25, 2019

Study Type : In Vitro Study

Additional Links

Substances : Choline

Pharmacological Actions : Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation

[+]

Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Immunopharmacol Immunotoxicol. 2015 ;37(5):473-80. PMID: 26466646

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Immunomodulatory, Interleukin-12 downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Curcumin inhibits human pancreatic cancer cell growth. Nov 15, 2004

Click here to read the entire abstract

Pubmed Data : Cancer. 2004 Nov 15;101(10):2351-62. PMID: 15476283

Article Published Date : Nov 15, 2004

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Pancreatic Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Interleukin-8 downregulation, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation

[+]

Curcumin inhibits lipopolysaccharide-induced inflammation. Jul 01, 2010

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2010 Jul;10(7):760-8. Epub 2010 Apr 22. PMID: 20399909

Article Published Date : Jul 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

[+]

Curcumin may be a promising pharmacological candidate for neurodegenerative diseases.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2016 ;11(1):e0147721. Epub 2016 Jan 29. PMID: 26824354

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Alzheimer's Disease, Neurodegenerative Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation

[+]

Curcumin significantly decreased the LPS-induced pro-inflammatory mediators NO, PGE2, and IL-6 by inhibiting the activation of NF-κB.Jun 30, 2015

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Jul ;18(7):786-92. Epub 2014 Dec 9. PMID: 25490740

Article Published Date : Jun 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin: Lipidated

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation

[+]

Dandelion leaves have an anti-inflammatory effect on lipopolysaccharide-induced inflammation. Aug 01, 2010

Click here to read the entire abstract

Pubmed Data : J Med Food. 2010 Aug;13(4):870-8. PMID: 20673058

Article Published Date : Aug 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Dandelion

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

[+]

Desoxo-narchinol-A isolated from Nardostachys jatamansi exhibits protective effects against LPS-induced endotoxin shock and inflammation.Nov 30, 2015

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2015 Dec ;29(2):730-8. Epub 2015 Sep 11. PMID: 26371857

Article Published Date : Nov 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Spikenard

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

Dietary interventions to increase the dihomo-gamma-linoleic acid to arachidonic acid ratio may not necessarily decrease PGE2 synthesis in tissues where COX-1 enzymes predominate over COX-2.Jul 15, 2002

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biochem J. 2002 Jul 15 ;365(Pt 2):489-96. PMID: 11939906

Article Published Date : Jul 15, 2002

Study Type : In Vitro Study

Additional Links

Therapeutic Actions : Dietary Modification: Alteration of Dietary Fat Types and/or Ratios

Pharmacological Actions : Prostaglandin PGE2 downregulation

Additional Keywords : Anti-Inflammatory Agents, arachidonic acid, Cyclooxygenase Inhibitors, Essential Fatty Acids, Gamma-Linoleic Acid GLA, Inflammation, omega-6 fatty acids, Prostaglandin E2

[+]

Dietary omega-3 fatty acids, curcumin and capsaicin lower the release of lysosomal enzymes and eicosanoids in rat peritoneal macrophages associated with inflammation. Jan 01, 2000

Click here to read the entire abstract

Pubmed Data : Mol Cell Biochem. 2000 Jan;203(1-2):153-61. PMID: 10724344

Article Published Date : Jan 01, 2000

Study Type : In Vitro Study

Additional Links

Substances : Capsaicin, Curcumin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Leukotriene B4 downregulation , Leukotriene C4 Downregulation, Prostaglandin PGE2 downregulation

[+]

Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cells.Aug 24, 2007

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2007 Aug 24;360(2):441-6. Epub 2007 Jun 19. PMID: 17599805

Article Published Date : Aug 24, 2007

Study Type : In Vitro Study

Additional Links

Substances : Echinacea

Diseases : Inflammation

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

[+]

Ellagic acid, gallic acid and punicalagin may be the compounds responsible for the anti-inflammatory potential of P. granatum.Jan 13, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2017 Jan 14 ;17(1):47. Epub 2017 Jan 14. PMID: 28088220

Article Published Date : Jan 13, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ellagic Acid, Gallic Acid, Pomegranate, Punicalagin

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation

[+]

Fermented Arctium lappa fruit extract had an inhibitory effect on the IgE-mediated allergic response in RBL‑2H3 cells.Dec 27, 2015

Click here to read the entire abstract

Pubmed Data : Int J Mol Med. 2015 Dec 28. Epub 2015 Dec 28. PMID: 26707911

Article Published Date : Dec 27, 2015

Study Type : In Vitro Study

Additional Links

Substances : Burdock

Diseases : Allergies

Pharmacological Actions : Anti-Allergic Agents, Anti-Inflammatory Agents, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response

[+]

HDMPPA may exert anti-inflammatory responses by suppressing LPS-induced expression of proinflammatory mediators and cytokines.May 31, 2015

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Jun ;18(6):677-84. Epub 2015 Apr 28. PMID: 25919915

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Kimchi

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Hesperidin may be a potential agent for the treatment of osteoarthritis.Sep 30, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2018 Oct ;16(4):3721-3727. Epub 2018 Aug 20. PMID: 30233731

Article Published Date : Sep 30, 2018

Study Type : In Vitro Study

Additional Links

Substances : Hesperidin

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation

[+]

Immunomodulatory effect of curcumin on lipopolysaccharide- and/or flagellin-induced production of prostaglandin E2 and relative expression of proinflammatory cytokines.May 31, 2019

Click here to read the entire abstract

Pubmed Data : Reprod Domest Anim. 2019 Jun ;54(6):917-923. Epub 2019 May 10. PMID: 30972855

Article Published Date : May 31, 2019

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Endometritis, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Immunomodulatory, Prostaglandin PGE2 downregulation

[+]

Lion's mane suppresses LPS-induced pro-inflammation gene activation in macrophages.Nov 29, 2011

Click here to read the entire abstract

Pubmed Data : Immunopharmacol Immunotoxicol. 2011 Nov 29. Epub 2011 Nov 29. PMID: 22126451

Article Published Date : Nov 29, 2011

Study Type : In Vitro Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus)

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Nitric Oxide Enhancer, Prostaglandin PGE2 downregulation, Reactive Oxygen Species (ROS) attenuation

[+]

M. oleifera extracts suppressed the expression of inflammatory mediators in LPS stimulated macrophages.Sep 30, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Pharmacogn Mag. 2015 Oct ;11(Suppl 4):S556-63. PMID: 27013794

Article Published Date : Sep 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Moringa oleifera

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-10 upregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation

[+]

M. oleifera flower extract can be a potent inhibitor of inflammation through NF-κB signaling pathway. Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mediators Inflamm. 2015 ;2015:720171. Epub 2015 Nov 2. PMID: 26609199

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Moringa oleifera

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Nexrutine treatment inhibited growth of pancreatic cancer cells through induction of apoptosis.Feb 28, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Clin Cancer Res. 2014 Mar 1 ;20(5):1259-73. Epub 2014 Feb 11. PMID: 24520096

Article Published Date : Feb 28, 2014

Study Type : In Vitro Study

Additional Links

Substances : Nexrutine (Phellodendrom)

Diseases : Pancreatic Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation, STAT3 Inhibitor

Additional Keywords : Plant Extracts

[+]

Orange peel extracts could provide useful protection against or alleviation of UV damage.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Exp Dermatol. 2014 Oct ;23 Suppl 1:18-22. PMID: 25234831

Article Published Date : Sep 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Citrus Peel , Flavonoids, Oranges

Diseases : Inflammation, Ultraviolet Radiation Induced Damage

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation, Radioprotective

Additional Keywords : Plant Extracts

[+]

Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity.Mar 01, 1987

Click here to read the entire abstract

Pubmed Data : Proc Natl Acad Sci U S A. 1987 Mar ;84(5):1417-20. PMID: 3103135

Article Published Date : Mar 01, 1987

Study Type : In Vitro Study

Additional Links

Substances : Salicylic acid

Diseases : Inflammation

Pharmacological Actions : Cyclooxygenase Inhibitors, Prostaglandin PGE2 downregulation

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Aspirin

[+]

Phloretin has an anti-inflammatory effect that reduces levels of proinflammatory cytokines.Sep 14, 2012

Click here to read the entire abstract

Pubmed Data : Food Chem. 2012 Sep 15 ;134(2):972-9. Epub 2012 Mar 7. PMID: 23107715

Article Published Date : Sep 14, 2012

Study Type : In Vitro Study

Additional Links

Substances : Phloretin

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation

[+]

Piperine inhibited LPS-induced inflammatory response by activating Nrf2 signaling pathway.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Int Immunopharmacol. 2017 Jan ;42:44-48. Epub 2016 Nov 19. PMID: 27875748

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Piperine

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Nrf2 activation, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Anti-Inflammatory Agents, Inflammation, Interleukin-1 beta downregulation, Lipopolysaccharide-Induced Toxicity, Piperine

[+]

Purple carrot anthocyanins down-regulates the mRNA expression of proinflammatory interleukins as well as inflammatory mediators.Nov 26, 2015

Click here to read the entire abstract

Pubmed Data : Food Funct. 2015 Nov 27. Epub 2015 Nov 27. PMID: 26613574

Article Published Date : Nov 26, 2015

Study Type : In Vitro Study

Additional Links

Substances : Purple Carrots

Diseases : Gastrointestinal Inflammation, Inflammatory Bowel Diseases

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, Prostaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

[+]

Review: green mussel extract has anti-inflammatory activity. Sep 01, 2000

Click here to read the entire abstract

Pubmed Data : Allerg Immunol (Paris). 2000 Sep;32(7):272-8. PMID: 11094640

Article Published Date : Sep 01, 2000

Study Type : Review

Additional Links

Substances : Mussel: Green-lipped (Perna canaliculus)

Diseases : Arthritis, Asthma, Rheumatoid Arthritis

Pharmacological Actions : Leukotriene B4 downregulation , Prostaglandin PGE2 downregulation

Additional Keywords : NSAID Alternatives

[+]

Rice bran extract is able to affect microglial activation by interfering in important inflammatory pathway.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Neuroinflammation. 2016 ;13(1):148. Epub 2016 Jun 14. PMID: 27301644

Article Published Date : Dec 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Rice Bran

Diseases : Alzheimer's Disease, Brain Inflammation , Neurodegenerative Diseases

Pharmacological Actions : Interleukin-10 upregulation, Interleukin-1 beta downregulation, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

[+]

Sesamol ameliorated inflammatory and oxidative damage.Jul 31, 2015

Click here to read the entire abstract

Pubmed Data : Inflamm Res. 2015 Aug ;64(8):577-88. Epub 2015 Jun 10. PMID: 26059394

Article Published Date : Jul 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Sesamol

Diseases : Inflammation, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Nrf2 activation, Prostaglandin PGE2 downregulation

[+]

Taraxasterol may be a useful agent for prevention and treatment of osteoarthritis.Jun 04, 2015

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2015 Jun 5 ;756:38-42. Epub 2015 Mar 20. PMID: 25797286

Article Published Date : Jun 04, 2015

Study Type : In Vitro Study

Additional Links

Substances : Dandelion

Diseases : Osteoarthritis

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix Metalloproteinase-13 (MMP-13) Inhibitor, Matrix metalloproteinase-1 (MMP-1) inhibitor, Matrix metalloproteinase-3 (MMP-3) inhibitor, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation

[+]

The anti-inflammatory effect of supercritical-carbon dioxide fluid extract from flowers and buds of Chrysanthemum indicum.Dec 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2013 ;2013:413237. Epub 2013 Oct 8. PMID: 24223056

Article Published Date : Dec 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Chrysanthemum Indicum

Diseases : Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Prostaglandin PGE2 downregulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Dose Response

[+]

The citrus flavone nobiletin has beneficial actions of reducing pro-inflammatory and pro-labour mediators in the presence of bacterial endotoxin lipopolysaccharide.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2014 ;9(9):e108390. Epub 2014 Sep 19. PMID: 25238390

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Fruit: All, Nobiletin , Vegetables: All

Diseases : Inflammation, Preterm Birth: Prevention

Additional Keywords : Risk Reduction

[+]

The metabolic and molecular mechanisms of α‑mangostin in cardiometabolic disorders.Aug 31, 2022

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Med. 2022 Sep ;50(3). Epub 2022 Jul 29. PMID: 35904170

Article Published Date : Aug 31, 2022

Study Type : Review

Additional Links

Substances : Xanthones

Diseases : Cardiovascular Diseases, Metabolic Diseases

Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation

[+]

The results suggest that horseradish root exerts an antiphlogistic activity in human immune cells.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:1950692. Epub 2017 Jan 15. PMID: 28182113

Article Published Date : Dec 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Horseradish

Diseases : Inflammation, Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

Additional Keywords : Anti-Inflammatory Agents, Horseradish, Inflammation, Lipopolysaccharide-Induced Toxicity

[+]

These findings provide novel insights into the anti-neuroinflammatory effects of Allyl isothiocyanate on microglial cells.Jul 02, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2017 Jul 3 ;18(7). Epub 2017 Jul 3. PMID: 28671636

Article Published Date : Jul 02, 2017

Study Type : In Vitro Study

Additional Links

Substances : Isothiocyanates, Wasabi

Diseases : Brain Inflammation

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-6 Downregulation, Neuroprotective Agents, NF-kappaB Inhibitor, Prostaglandin PGE2 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

These findings suggest that myricetin has therapeutic effects in the form of controlling lipoteichoic acid-induced inflammatory responses.Nov 30, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Microbiol Immunol. 2013 Dec ;57(12):849-56. PMID: 24117794

Article Published Date : Nov 30, 2013

Study Type : In Vitro Study

Additional Links

Substances : Myricetin

Diseases : Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Prostaglandin PGE2 downregulation

[+]

These results thus demonstrate that VA-mediated inhibition of PGE2 implicates destabilization of COX-2 mRNA. Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(2):e0114965. Epub 2015 Feb 9. PMID: 25664986

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Mistletoe

Diseases : Inflammation, Lung Cancer

Pharmacological Actions : Cyclooxygenase 1 Inhibitor, MicroRNA modulator, Prostaglandin PGE2 downregulation

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View the Evidence: 89 Abstracts with Prostaglandin PGE2 downregulation Research

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Bromelain has no difference in reducing symptoms of mild-to-moderate knee OA after 4 weeks when compared with diclofenac.Sep 30, 2016

Cherry juice increased sleep time and sleep efficiency. Mar 26, 2017

Consumption of the vegetable soup decreases oxidative stress and biomarkers of inflammation, which indicates that the protective effect of vegetables may extend beyond their antioxidant capacity.Oct 31, 2004

Dosage Study: A daily dose of 3.6 g of curcumin engendered 62% and 57% decreases in inducible PGE(2) production in blood samples taken 1 hour after dose on days 1 and 29, respectively, in patients with advanced colorectal cancer.Oct 15, 2004

Gazpacho soup consumption significantly increases plasma concentrations of vitamin C and significantly decreases 8-epi-PGF2alpha, PGE2 and MCP-1 concentrations in healthy humansFeb 28, 2006

Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis.Jan 31, 2016

Turmeric gel can be effectively used as an adjunct to mechanical plaque control in the prevention of plaque and gingivitis.Dec 31, 2014

Ginsenoside Rg1 can inhibit inflammatory responses in human chondrocytes in vitro and reduce articular cartilage damage in vivo.Mar 09, 2017

Melatonin is a potential candidate compound for the treatment of proinflammatory disorders.Aug 31, 2012

Phloretin inhibits interleukin-1β-induced COX-2 and ICAM-1 in human lung epithelial cells.May 31, 2015

Berberin inhibited colorectal cancer invasion and metastasis via down regulation of COX-2/PGE2- JAK2/STAT3 signaling pathway.Dec 31, 2014

An extract of polymethoxyflavones from Billygoat weed exhibited significant antinociceptive and anti-inflammatory effects.Sep 11, 2016

An immune-modulating diet in combination with chemotherapy prevented cancer cachexia without suppressing chemotherapeutic efficacy.Jul 01, 2015

Berberine suppresses growth and metastasis of endometrial cancer cells.Jun 30, 2018

Boswellia's anti-inflammatory activity is due in part to its inhibition of prostaglandin E2 synthesis.Jan 01, 2011

Curcumin and NAC prevent fatty acid changes produced by ethanol and also reduce the inflammatory response of ethanol by reducing the level of prostaglandins.Mar 01, 2005

Curcumin has therapeutic effects in chemically-induced colitis. Jun 28, 2006

Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats.Aug 01, 2006

Extra virgin olive oil is a beneficial functional food exerting a preventive/palliative role in the management of systemic lupus erythematosus.Dec 31, 2015

Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.Dec 21, 2016

Fisetin may be a potential agent in the treatment of osteoarthritis.Feb 13, 2017

L‑carnitine ameliorated liver inflammation and serum pro‑inflammatory markers in cancer cachexia.Dec 03, 2015

Oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia.Feb 29, 2004

Phloretin may be a potential agent for the treatment of osteoarthritis.Nov 22, 2017

Piceatannol may be a potential therapeutic agent for osteoarthritis.Nov 14, 2017

Polysaccharides from Acanthopanax senticosus enhances intestinal integrity in lipopolysaccharide-challenged mice.Jul 31, 2016

Pomegranate extract is abundant in hydrolysable tannins that display multiple anti-acne capacities.Jan 11, 2017

Sesame lignans inhibit delta-5 desaturase activity, increasing dihomo-gamma-linoleic acid levels and decreasing prostaglandin E2 synthesis.Mar 01, 1998

Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells.Feb 28, 2014

Sulforaphane may be a potential a candidate for use in the treatment of acute lung injury.Dec 31, 2015

Taraxasterol has the potential protective effect against Freund's complete adjuvant induced arthritis in rats.Apr 20, 2016

The flower extract of Rosa rugosa may be a beneficial anti-inflammatory agent.Feb 29, 2016

The present investigation provides pharmacological evidence to support the folklore claim that J. gendarussa is an anti-inflammatory agent.Jun 30, 2011

The results indicate a potential for therapeutic use of cannabidiol in chronic painful states.Feb 04, 2007

Thymoquinone inhibits LoVo cancer cell growth and migration.Feb 20, 2017

Treatment with taraxasterol significantly increased the pain thresholds and reduced the clinical arthritic scores of mice.Nov 30, 2016

Triphala has a promising anti-inflammatory effect in the inflamed paw of arthritis-induced rats.Dec 31, 2014

Volatile oil of Angelica sinensis roots could significantly inhibit the release of PGE2, HIS, 5-HT and TNF-α.Sep 14, 2016

β-patchoulene isolated from patchouli oil had Anti-inflammatory activity.Apr 13, 2016

ω-3 polyunsaturated fatty acids had inhibitory effects on endometrial cancer development.Dec 31, 2014

6-gingerol has potential use in treating inflammatory bone destruction associated with excessive prostaglandin E2 production.Jul 15, 2018

6-shogaol and curcumin might be effective on GSK3β pathway via lowering PGE2 levels.Oct 24, 2016

A hexane fraction of P. vulgaris var. lilacina may be a potent anti-inflammatory candidate.Dec 31, 2012

An extract of A. annua was shown to be a potent inhibitor of TNF-α and a strong inhibitor of PGE2 production in activated neutrophils.Dec 31, 2014

Artemisia annua L. extracts contain anti-inflammatory, antioxidant, and antimicrobial substances and should be considered for use in pharmaceutical products for the treatment of dental diseases.Dec 31, 2014

Arthrocen could potentially bring about the reduced pain produced by COX‐2 inhibitors without the known side effects of COX‐2 inhibition.Jan 31, 2017

Astaxanthin attenuates the UVB-induced secretion of prostaglandin E(2) and interleukin-8, indicating its possible role in minimizing inflammation associated with skin damage.Jul 01, 2012

B. serrata extract inhibits proliferation, angiogenesis and migration and induces apoptosis in HT-29 cellsMay 23, 2017

Biochanin A is an attractive compound for preventing 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced wasting syndrome.Dec 31, 2018

C. longa and curcumin might decrease the risk of cancer and other malignant diseases in the reproductive system. Oct 25, 2017

C. vulgaris possesses significant anti-inflammatory activity and could be a potential anti-inflammatory agent of natural origin.Mar 31, 2016

Celecoxib and curcumin work synergistically to inhibit the growth of colorectal cancer cells.Sep 15, 2005

Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.Nov 25, 2019

Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects.Dec 31, 2014

Curcumin inhibits human pancreatic cancer cell growth. Nov 15, 2004

Curcumin inhibits lipopolysaccharide-induced inflammation. Jul 01, 2010

Curcumin may be a promising pharmacological candidate for neurodegenerative diseases.Dec 31, 2015

Curcumin significantly decreased the LPS-induced pro-inflammatory mediators NO, PGE2, and IL-6 by inhibiting the activation of NF-κB.Jun 30, 2015

Dandelion leaves have an anti-inflammatory effect on lipopolysaccharide-induced inflammation. Aug 01, 2010

Desoxo-narchinol-A isolated from Nardostachys jatamansi exhibits protective effects against LPS-induced endotoxin shock and inflammation.Nov 30, 2015

Dietary interventions to increase the dihomo-gamma-linoleic acid to arachidonic acid ratio may not necessarily decrease PGE2 synthesis in tissues where COX-1 enzymes predominate over COX-2.Jul 15, 2002

Dietary omega-3 fatty acids, curcumin and capsaicin lower the release of lysosomal enzymes and eicosanoids in rat peritoneal macrophages associated with inflammation. Jan 01, 2000

Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cells.Aug 24, 2007

Ellagic acid, gallic acid and punicalagin may be the compounds responsible for the anti-inflammatory potential of P. granatum.Jan 13, 2017

Fermented Arctium lappa fruit extract had an inhibitory effect on the IgE-mediated allergic response in RBL‑2H3 cells.Dec 27, 2015

HDMPPA may exert anti-inflammatory responses by suppressing LPS-induced expression of proinflammatory mediators and cytokines.May 31, 2015

Hesperidin may be a potential agent for the treatment of osteoarthritis.Sep 30, 2018

Immunomodulatory effect of curcumin on lipopolysaccharide- and/or flagellin-induced production of prostaglandin E2 and relative expression of proinflammatory cytokines.May 31, 2019

Lion's mane suppresses LPS-induced pro-inflammation gene activation in macrophages.Nov 29, 2011

M. oleifera extracts suppressed the expression of inflammatory mediators in LPS stimulated macrophages.Sep 30, 2015

M. oleifera flower extract can be a potent inhibitor of inflammation through NF-κB signaling pathway. Dec 31, 2014

Nexrutine treatment inhibited growth of pancreatic cancer cells through induction of apoptosis.Feb 28, 2014

Prostaglandin PGE2 downregulation

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89 Abstracts with Prostaglandin PGE2 downregulation Research