Proteasome Inhibitors

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37 Substances Researched for Proteasome Inhibitors
NameACCKFocus
Curcumin1217Locked
Resveratrol56Locked
Curry Leaves23Locked
Apigenin22Locked
Bamboo12Locked
Catechin 22Locked
Chrysin22Locked
Flavonoids22Locked
Fucoidan12Locked
Gingerol 12Locked
Lignans12Locked
Luteolin22Locked
Polyphenols22Locked
Quercetin22Locked
Sulforaphane22Locked
Theophylline12Locked
Arnica11Locked
Bufalin11Locked
Caffeic acid phenethyl ester11Locked
Cinnamon11Locked
Cruciferous Vegetables11Locked
EGCG (Epigallocatechin gallate)11Locked
Fruit: All11Locked
Genistein11Locked
Grapefruit11Locked
Helenalin11Locked
Hydroxytyrosol11Locked
Indole-3-Carbinol11Locked
Licorice11Locked
Naringenin 11Locked
Oats11Locked
Orange11Locked
Pomelo11Locked
Procyanidin B2 11Locked
Pterostilbene11Locked
Vegetables: All 11Locked
Wheat Grass11Locked

View the Evidence:
40 Abstracts with Proteasome Inhibitors Research

[+]

Statins may adversely alter the response of muscle to exercise stress.Dec 01, 2005

Pubmed Data : Arterioscler Thromb Vasc Biol. 2005 Dec ;25(12):2560-6. Epub 2005 Oct 13. PMID: 16224050
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Diseases : Athletic Performance, Drug-Induced Nutrient Depletion: Statin Drugs, Exercise-Induced Tissue Damage, Muscle Damage: Exercise-Induced
Pharmacological Actions : Proteasome Inhibitors
Problem Substances : Atorvastatin, Statin Drugs
[+]

6-Gingerol is a potent inducer of p53 reactivation in HPV positive cervical cancer cells through proteasome inhibition.Nov 24, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2015 Nov 25. Epub 2015 Nov 25. PMID: 26621832
Article Published Date : Nov 24, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Gingerol
Diseases : Cervical Cancer
Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer, Proteasome Inhibitors, Tumor Suppressor Protein p53 Upregulation
Additional Keywords : Reactivation Of Tumor Suppressor Gene
[+]

Both curcumin and resveratrol show promise as anti-cachexia agents, whereas resveratrol performed better in this study.Nov 01, 2004

Pubmed Data : Br J Cancer. 2004 Nov 1;91(9):1742-50. PMID: 15477867
Article Published Date : Nov 01, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin, Resveratrol
Diseases : Cachexia, Muscle Atrophy
Pharmacological Actions : Enzyme Inhibitors, NF-kappaB Inhibitor, Proteasome Inhibitors
Additional Keywords : Stilbenes
[+]

Curcumin blocks sepsis-induced muscle proteolysis.Jan 01, 2008

Pubmed Data : Mediators Inflamm. 2008;2008:317851. PMID: 18389075
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Muscle Atrophy , Sepsis
Pharmacological Actions : NF-kappaB Inhibitor, Proteasome Inhibitors
[+]

Curcumin inhibits muscle wasting in colon tumor bearing mice.Oct 01, 2009

Pubmed Data : Br J Nutr. 2009 Oct;102(7):967-75. Epub 2009 Apr 27. PMID: 19393114
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Cachexia, Colon Cancer, Muscle Atrophy
Pharmacological Actions : Proteasome Inhibitors
[+]

Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.Sep 15, 2008

Pubmed Data : Cancer Res. 2008 Sep 15;68(18):7283-92. PMID: 18794115
Article Published Date : Sep 15, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Colon Cancer
Pharmacological Actions : Apoptotic, Proteasome Inhibitors
[+]

Curcumin may prove useful for patients with diabetes by improving both β-cell function and relieving insulin resistance.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Diabetes. 2016 ;6:e205. Epub 2016 Apr 25. PMID: 27110686
Article Published Date : Dec 31, 2015
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Diabetes Mellitus: Type 2, Insulin Resistance
Pharmacological Actions : Insulin Sensitizers, Proteasome Inhibitors
[+]

Fucoidan could inhibit of lung cancer in vivo and in vitro.Sep 14, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Oncotarget. 2014 Sep 15 ;5(17):7870-85. PMID: 25149540
Article Published Date : Sep 14, 2014
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fucoidan
Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer
Pharmacological Actions : Antiproliferative , Proteasome Inhibitors
[+]

Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo.Oct 01, 2006

Pubmed Data : J Pharmacol Sci. 2006 Oct;102(2):196-204. Epub 2006 Oct 7. PMID: 17031070
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Substances : Bamboo, Lignans
Diseases : Brain Damage, Neurodegenerative Diseases
Pharmacological Actions : Apoptotic, Neuroprotective Agents, Proteasome Inhibitors
[+]

Murraya koenigii and its flavonoid compounds which act as proteasome inhibitors.May 19, 2016

Pubmed Data : Anticancer Agents Med Chem. 2016 May 20. Epub 2016 May 20. PMID: 27198988
Article Published Date : May 19, 2016
Study Type : Animal Study
Additional Links
Substances : Curry Leaves
Diseases : Breast Cancer: Triple Negative
Pharmacological Actions : Angiogenesis Inhibitors, Apoptotic, Cell cycle arrest, Proteasome Inhibitors
Additional Keywords : Dose Response
[+]

Theophylline could be used in the treatment of muscle wasting associated with cancer cachexia.Dec 31, 2011

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutr Metab (Lond). 2012 ;9(1):76. Epub 2012 Aug 21. PMID: 22909172
Article Published Date : Dec 31, 2011
Study Type : Animal Study
Additional Links
Substances : Theophylline
Diseases : Cachexia, Muscle Atrophy
Pharmacological Actions : anti-inflammatory, Cardioprotective, Proteasome Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Gene Expression Regulation
[+]

"Identification of pancreatic cancer stem cells and selective toxicity of chemotherapeutic agents."Jun 30, 2012

Pubmed Data : Gastroenterology. 2012 Jul ;143(1):234-45.e7. Epub 2012 Apr 14. PMID: 22510202
Article Published Date : Jun 30, 2012
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Cancer Stem Cells, Pancreatic Cancer, Pancreatic Stem Cell
Pharmacological Actions : Antineoplastic Agents, Proteasome Inhibitors
[+]

A green tea extract inhibits the growth of human Barrett's and aerodigestive cancer cells.Jan 15, 2009

Pubmed Data : Clin Cancer Res. 2009 Jan 15;15(2):622-31. PMID: 19147768
Article Published Date : Jan 15, 2009
Study Type : In Vitro Study
Additional Links
Substances : Catechin , EGCG (Epigallocatechin gallate), Polyphenols
Diseases : Barrett Esophagus, Esophageal Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Cell cycle arrest, Proteasome Inhibitors
[+]

A Mediterranean diet may protect against homocysteine-induced cardiovascular damage. Sep 01, 2010

Pubmed Data : Chemosphere. 2010 Sep;81(4):464-8. PMID: 17586618
Article Published Date : Sep 01, 2010
Study Type : Commentary
Additional Links
Substances : Flavonoids, Hydroxytyrosol, Polyphenols, Resveratrol
Diseases : High Homocysteine
Therapeutic Actions : Dietary Modification: Mediterranean Diet
Pharmacological Actions : Antioxidants, Proteasome Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Cell Adhesion Molecule-1 Inhibitor
Additional Keywords : Stilbenes
[+]

A variety of natural substances may function as novel anticancer agents, proteasome inhibitors and chemosensitizers. Dec 01, 2006

Pubmed Data : Drug Resist Updat. 2006 Dec;9(6):263-73. Epub 2007 Jan 2. PMID: 17197231
Article Published Date : Dec 01, 2006
Study Type : Review
Additional Links
Substances : Catechin , Curcumin, Genistein, Resveratrol
Diseases : Cancers: Drug Resistant
Pharmacological Actions : Antineoplastic Agents, Chemosensitizer, Proteasome Inhibitors, Radiosensitizer
Additional Keywords : Stilbenes
[+]

Apigenin, chrysin, and luteolin may inhibit tumor cells via proteasome inhibitory activity. Feb 01, 2010

Pubmed Data : Planta Med. 2010 Feb;76(2):128-32. Epub 2009 Aug 3. PMID: 19653143
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Chrysin, Luteolin
Diseases : Cancers: All, Tumors
Pharmacological Actions : Enzyme Inhibitors, Proteasome Inhibitors
[+]

Bufalin inhibits glioblastoma growth by promoting proteasomal degradation of the Na+/K+-ATPase α1 subunit.Jun 30, 2018

Pubmed Data : Biomed Pharmacother. 2018 Jul ;103:204-215. Epub 2018 Apr 24. PMID: 29653366
Article Published Date : Jun 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Bufalin
Diseases : Glioblastoma
Pharmacological Actions : Antiproliferative , Proteasome Inhibitors
[+]

Caffeic acid phenethyl ester potentiates gastric cancer cell sensitivity to doxorubicin and cisplatin.Nov 25, 2018

Pubmed Data : Anticancer Drugs. 2018 Nov 26. Epub 2018 Nov 26. PMID: 30489290
Article Published Date : Nov 25, 2018
Study Type : In Vitro Study
Additional Links
Substances : Caffeic acid phenethyl ester
Diseases : Gastric Cancer
Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Proteasome Inhibitors
Additional Keywords : Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin
[+]

Curcumin exhibits both anti-proliferative and anti-inflammatory activities.Jan 01, 2006

Pubmed Data : Neurotox Res. 2006 Jan;9(1):29-37. PMID: 16464750
Article Published Date : Jan 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Cancers: All, Inflammation
Pharmacological Actions : Enzyme Inhibitors, NF-kappaB Inhibitor, Proteasome Inhibitors
[+]

Curcumin has heat shock inducing properties.May 01, 2006

Pubmed Data : Ann N Y Acad Sci. 2006 May;1067:394-9. PMID: 16804017
Article Published Date : May 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Heat Shock Protein Inducer, Proteasome Inhibitors
[+]

Curcumin induces cell death in oesophageal cancer cells.Nov 03, 2009

Pubmed Data : Br J Cancer. 2009 Nov 3;101(9):1585-95. Epub 2009 Oct 6. PMID: 19809435
Article Published Date : Nov 03, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Esophageal Cancer
Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cell cycle arrest, Proteasome Inhibitors
[+]

Curcumin is an inhibitor of p300 histone acetylatransferase capable of blocking prostate cancer cells.Mar 01, 2006

Pubmed Data : Med Chem. 2006 Mar;2(2):169-74. PMID: 16787365
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Prostate Cancer
Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Enzyme Inhibitors, Histone deacetylase inhibitor, Proteasome Inhibitors
[+]

Curcumin may be effective for the prevention of severe lower respiratory tract disease in infants and young children.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2013 ;8(9):e70225. Epub 2013 Sep 18. PMID: 24058438
Article Published Date : Dec 31, 2012
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Respiratory Syncytial Virus Infections
Pharmacological Actions : Antiviral Agents, Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, NF-kappaB Inhibitor, Proteasome Inhibitors
[+]

Curcumin may have therapeutic value in cancer as a proteasome inhibitor.Oct 01, 2010

Pubmed Data : Int J Mol Med. 2010 Oct;26(4):447-55. PMID: 20818481
Article Published Date : Oct 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Antineoplastic Agents, Enzyme Inhibitors, Proteasome Inhibitors
[+]

Helenalin, a compound found within Arnica, may have a role as an immunosuppressive compound suited for the treatment of deregulated and unwanted T cell-mediated immune responses.Sep 01, 2009

Pubmed Data : Mol Immunol. 2009 Sep;46(15):2892-901. Epub 2009 Aug 5. PMID: 19656571
Article Published Date : Sep 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Arnica, Helenalin
Diseases : Immune Dysregulation: TH1/TH2 imbalance
Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, Immunosuppressive Agents, NF-kappaB Inhibitor, Proteasome Inhibitors, Tumor Suppressor Protein p53 Upregulation
[+]

Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts.Aug 31, 2015

Pubmed Data : J Basic Clin Physiol Pharmacol. 2015 Sep ;26(5):471-7. PMID: 26030791
Article Published Date : Aug 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Grapefruit, Orange, Pomelo
Diseases : Colon Cancer
Pharmacological Actions : Anti-metastatic, Proteasome Inhibitors
Additional Keywords : Plant Extracts
[+]

Licochalcone-A sensitizes human esophageal carcinoma cells to TRAIL-mediated apoptosis by proteasomal degradation of XIAP.Jun 30, 2014

Pubmed Data : Hepatogastroenterology. 2014 Jul-Aug;61(133):1229-34. PMID: 25436288
Article Published Date : Jun 30, 2014
Study Type : In Vitro Study
Additional Links
Substances : Licorice
Diseases : Esophageal Cancer
Pharmacological Actions : Apoptotic, Chemosensitizer, Proteasome Inhibitors
Additional Keywords : Drug Synergy
[+]

Mevastatin exhibits potential neurotoxicity. Jun 01, 2002

Pubmed Data : J Neurosci Res. 2002 Jun 1 ;68(5):627-35. PMID: 12111853
Article Published Date : Jun 01, 2002
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Proteasome Inhibitors
Problem Substances : Mevastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Oats may reduce chronic inflammation of arterial walls associated with the development of atherosclerosis.Feb 01, 1987

Pubmed Data : Biull Eksp Biol Med. 1987 Feb;103(2):212-5. PMID: 18062932
Article Published Date : Feb 01, 1987
Study Type : In Vitro Study
Additional Links
Substances : Oats
Diseases : Atherosclerosis, Endothelial Dysfunction, Inflammation
Pharmacological Actions : Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Interleukin-8 downregulation, NF-kappaB Inhibitor, Proteasome Inhibitors
[+]

Procyanidin-B2 enriched fraction of cinnamon acts as a proteasome inhibitor and anti-proliferative agent in human prostate cancer cells.Apr 30, 2018

Pubmed Data : IUBMB Life. 2018 May ;70(5):445-457. Epub 2018 Mar 14. PMID: 29537730
Article Published Date : Apr 30, 2018
Study Type : In Vitro Study
Additional Links
Substances : Cinnamon, Procyanidin B2
Diseases : Prostate Cancer
Pharmacological Actions : Antiproliferative , Proteasome Inhibitors
[+]

Pterostilbene is equipotent to resveratrol in inhibiting inflammation, but may be more bioavailable due to its higher lipophilicity.Jun 01, 2008

Pubmed Data : Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S62-70. PMID: 18551458
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene, Resveratrol
Diseases : Inflammation
Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, NF-kappaB Inhibitor, Proteasome Inhibitors
Additional Keywords : Stilbenes
[+]

Quercetin induces cell death in human hepatoma cells. Jan 01, 2010

Pubmed Data : Nutr Cancer. 2010 ;62(3):390-401. PMID: 20358477
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Liver Cancer
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, NF-kappaB Inhibitor, Proteasome Inhibitors
[+]

Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.Nov 11, 2005

Pubmed Data : J Biol Chem. 2005 Nov 11;280(45):37377-82. Epub 2005 Sep 14. PMID: 16162502
Article Published Date : Nov 11, 2005
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Alzheimer's Disease
Pharmacological Actions : Proteasome Inhibitors
Additional Keywords : Stilbenes
[+]

Review: Radiation resistance in breast cancer. Dec 31, 2009

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Breast Cancer Res. 2010 ;12(2):105. Epub 2010 Apr 7. PMID: 20377923
Article Published Date : Dec 31, 2009
Study Type : Review
Additional Links
Diseases : Breast Cancer, Breast Cancer Stem Cells, Cancer Stem Cells, Cancers: Radiation-Resistant
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Proteasome Inhibitors
Additional Keywords : Cancer Stem Cells
Anti Therapeutic Actions : Radiotherapy
[+]

Sulforaphane may protect against neurodegenerative disease.Sep 01, 2007

Pubmed Data : Free Radic Biol Med. 2007 Sep 1;43(5):809-17. Epub 2007 May 31. PMID: 17664144
Article Published Date : Sep 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Neurodegenerative Diseases
Pharmacological Actions : Neuroprotective Agents, Proteasome Inhibitors
[+]

Sulforaphane protects against amyloid beta cytotoxicity. Aug 13, 2009

Pubmed Data : Obesity (Silver Spring). 2009 Aug 13. Epub 2009 Aug 13. PMID: 19183883
Article Published Date : Aug 13, 2009
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Alzheimer's Disease
Pharmacological Actions : Antioxidants, Neuroprotective Agents, Proteasome Inhibitors
[+]

The dietary flavonoids luteolin, apigenin, chrysin and naringenin (found in fruits and vegetables) are potent natural proteasome inhibotrs and tumor cell death inducers. Jan 01, 2007

Pubmed Data : Front Biosci. 2007;12:1935-45. Epub 2007 Jan 1. PMID: 17127432
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Apigenin, Chrysin, Flavonoids, Fruit: All, Luteolin, Naringenin , Vegetables: All
Diseases : Cancers: All, Tumors
Pharmacological Actions : Anticarcinogenic Agents, Apoptotic, Chemopreventive, Proteasome Inhibitors
[+]

This study demonstrates that inhibition of the proteasome is an important biological activity of M. koenigii alkaloids.Nov 30, 2016

Pubmed Data : J Med Food. 2016 Dec ;19(12):1155-1165. PMID: 27982755
Article Published Date : Nov 30, 2016
Study Type : In Vitro Study
Additional Links
Substances : Curry Leaves
Diseases : Breast Cancer, Breast Cancer: Triple Negative
Pharmacological Actions : Antiproliferative , Apoptotic, Proteasome Inhibitors
Additional Keywords : Plant Extracts
[+]

This study identifies NEDD4-1 as a new I3C target protein, and that the I3C disruption of NEDD4-1 ubiquitination activity triggers the stabilization of the wild-type PTEN tumor suppressor.Oct 31, 2014

Pubmed Data : Mol Cancer Res. 2014 Nov ;12(11):1621-34. Epub 2014 Jul 9. PMID: 25009292
Article Published Date : Oct 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Cruciferous Vegetables, Indole-3-Carbinol
Diseases : Melanoma
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Proteasome Inhibitors
[+]

Wheat grass exact induces apoptosis in human cancer cells via proteasome modulation.Jul 01, 1997

Pubmed Data : Pharmacopsychiatry. 1997 Jul;30(4):133-4. PMID: 19527768
Article Published Date : Jul 01, 1997
Study Type : In Vitro Study
Additional Links
Substances : Wheat Grass
Diseases : Cancers: All
Pharmacological Actions : Apoptotic, Proteasome Inhibitors
Additional Keywords : Plant Extracts

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