Protein Kinase Inhibitors

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17 Substances Researched for Protein Kinase Inhibitors
NameACCKFocus
Curcumin67Locked
NAC (N-acetyl-L-cysteine)15Locked
Adlay23Locked
Bee Propolis12Locked
Ellagic Acid12Locked
Genistein12Locked
Niacin12Locked
Omega-3 Fatty Acids12Locked
Quercetin12Locked
Resveratrol22Locked
Sinomenine12Locked
Antineoplastons11Locked
Astragaloside11Locked
Deguelin11Locked
Hu Zhang (Polygonum cuspidatum)11Locked
Puerarin11Locked
Stilbenes11Locked

View the Evidence:
21 Abstracts with Protein Kinase Inhibitors Research

[+]

Topical N-acetylcysteine accelerates wound healing in vitro and in vivo via the PKC/Stat3 pathway.May 02, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2014 May 2 ;15(5):7563-78. Epub 2014 May 2. PMID: 24798751
Article Published Date : May 02, 2014
Study Type : Animal Study, Human In Vitro
Additional Links
Substances : NAC (N-acetyl-L-cysteine)
Diseases : Wound Healing
Pharmacological Actions : Antioxidants, Protein Kinase Inhibitors
[+]

Adlay bran extract reduced the release of histamines and cytokines and suppressed the production of Akt.May 06, 2012

Pubmed Data : J Ethnopharmacol. 2012 May 7 ;141(1):119-27. Epub 2012 Feb 14. PMID: 22353428
Article Published Date : May 06, 2012
Study Type : Animal Study
Additional Links
Substances : Adlay
Diseases : Leukemia
Pharmacological Actions : Anti-Allergic Agents, Interleukin-4 downregulation, Interleukin-6 Downregulation, Protein Kinase Inhibitors, Tumor Necrosis Factor (TNF) Alpha Inhibitor
Additional Keywords : Adlay, Anti-Allergic Agents, Interleukin-4 downregulation, leukemia, Phytotherapy, Plant Extracts
[+]

Brazillian green propolis suppresses neurofibromatosis-associated tumors. Mar 01, 2009

Pubmed Data : Phytother Res. 2009 Mar;23(3):423-7. PMID: 19003952
Article Published Date : Mar 01, 2009
Study Type : Animal Study
Additional Links
Substances : Bee Propolis
Diseases : Neurofibromatosis
Pharmacological Actions : Protein Kinase Inhibitors
Additional Keywords : Kinase PAK1 Inhibitor
[+]

Curcumin inhibits radiation-induced changes in the liver. Dec 01, 2001

Pubmed Data : J Radiol Prot. 2001 Dec;21(4):361-70. PMID: 11787891
Article Published Date : Dec 01, 2001
Study Type : Animal Study
Additional Links
Substances : Curcumin, Ellagic Acid, Quercetin
Diseases : Radiation Induced Illness
Pharmacological Actions : Hepatoprotective, Protein Kinase Inhibitors, Radioprotective
[+]

Genistein, a general kinase inhibitor, may be a potential antiviral for arenaviral hemorrhagic fever. Sep 01, 2010

Pubmed Data : Antiviral Res. 2010 Sep;87(3):318-28. Epub 2010 Jun 25. PMID: 20600333
Article Published Date : Sep 01, 2010
Study Type : Animal Study
Additional Links
Substances : Genistein
Diseases : Arenaviral Hemorrhagic Fever, Hemorrhagic Fevers: Viral
Pharmacological Actions : Antiviral Agents, Protein Kinase Inhibitors
[+]

Niacin, an innovative protein kinase-C-dependent endoplasmic reticulum stress reticence in murine Parkinson's disease.Aug 14, 2024

Pubmed Data : Life Sci. 2024 Aug 15 ;351:122865. Epub 2024 Jun 22. PMID: 38914304
Article Published Date : Aug 14, 2024
Study Type : Animal Study
Additional Links
Substances : Niacin
Diseases : Parkinson's Disease
Pharmacological Actions : Anti-Apoptotic, Neuroprotective Agents, Protein Kinase Inhibitors
[+]

Omega-3 polyunsaturated fatty acids has a preventive effect against atrial fibrillation in a canine model of pericarditis.Apr 01, 2010

Pubmed Data : Heart Rhythm. 2010 Apr;7(4):520-8. Epub 2009 Dec 28. PMID: 20156610
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Atrial Fibrillation, Pericarditis
Pharmacological Actions : Cardiovascular Agents, Epidermal growth factor receptor (EGFR) inhibitor, JAM3 gene down-regulation , Myosin heavy chain alpha (MHCalpha) reducer, Protein Kinase Inhibitors
[+]

Sinomenine protects against E.coli-induced acute lung injury in mice through Nrf2-NF-κB pathway.Oct 31, 2018

Pubmed Data : Biomed Pharmacother. 2018 Nov ;107:696-702. Epub 2018 Aug 20. PMID: 30138891
Article Published Date : Oct 31, 2018
Study Type : Animal Study
Additional Links
Substances : Sinomenine
Diseases : Escherichia coli Infections, Inflammation, Lung Injury: Acute, Oxidative Stress
Pharmacological Actions : Malondialdehyde Down-regulation, NF-kappaB Inhibitor, Protein Kinase Inhibitors, Superoxide Dismutase Up-regulation
[+]

Antineoplaston induces G(1) cell cycle arrest in breast cancer cells.Aug 01, 2005

Pubmed Data : Oncol Rep. 2005 Aug ;14(2):489-94. PMID: 16012735
Article Published Date : Aug 01, 2005
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Chemopreventive, Enzyme Inhibitors, Protein Kinase Inhibitors
[+]

Antineoplaston inhibits breast cancer cell growth through modulating cell cycle arrest. Jan 01, 2008

Pubmed Data : Breast Cancer. 2008 ;15(1):73-8. PMID: 18224398
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Antineoplastons
Diseases : Breast Cancer
Pharmacological Actions : Antineoplastic Agents, Cell cycle arrest, Protein Kinase Inhibitors
[+]

Astragaloside IV may be used as a natural medicine to treat EPCR-related systemic inflammation and cardiovascular diseases.May 31, 2017

Pubmed Data : Immunopharmacol Immunotoxicol. 2017 Jun ;39(3):148-156. Epub 2017 Apr 3. PMID: 28367652
Article Published Date : May 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside
Diseases : Cardiovascular Diseases
Pharmacological Actions : Cardioprotective, Protein Kinase Inhibitors
[+]

Curcumin has anti-breast cancer activity related to the activities of protein kinases on cell signal pathway.May 01, 2009

Pubmed Data : Zhong Yao Cai. 2009 May;32(5):728-32. PMID: 19771847
Article Published Date : May 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Enzyme Inhibitors, NF-kappaB Inhibitor, Protein Kinase Inhibitors
[+]

Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase.Mar 14, 1994

Pubmed Data : FEBS Lett. 1994 Mar 14;341(1):19-22. PMID: 7511111
Article Published Date : Mar 14, 1994
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Protein Kinase Inhibitors
[+]

Curcumin may be useful to prevent changes of atherosclerosis and post-angioplasty restenosis. Jul 01, 1998

Pubmed Data : Br J Pharmacol. 1998 Jul;124(6):1029-40. PMID: 9720770
Article Published Date : Jul 01, 1998
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Angioplasty, Atherosclerosis, Restenosis
Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Protein Kinase Inhibitors, Tumor Suppressor Protein p53 Upregulation
[+]

Curcumin may have a therapeutic role in reducing diabetic complications.Dec 01, 2003

Pubmed Data : J Biosci. 2003 Dec;28(6):715-21. PMID: 14660871
Article Published Date : Dec 01, 2003
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Diabetic Complications, Diabetic Retinopathy
Pharmacological Actions : Protein Kinase Inhibitors
[+]

Curcumin suppresses protein kinase C and nuclear oncogene expression associated with cancer progression.Jul 01, 2004

Pubmed Data : Arch Pharm Res. 2004 Jul;27(7):683-92. PMID: 15356994
Article Published Date : Jul 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Anticarcinogenic Agents, Oncogene Suppressor , Protein Kinase Inhibitors
[+]

Deguelin potentiates apoptotic activity of an EGFR tyrosine kinase inhibitor (AG1478) in PIK3CA-mutated head and neck squamous cell carcinoma.Jan 25, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2017 Jan 26 ;18(2). Epub 2017 Jan 26. PMID: 28134774
Article Published Date : Jan 25, 2017
Study Type : In Vitro Study
Additional Links
Substances : Deguelin
Diseases : Squamous cell carcinoma
Pharmacological Actions : Apoptotic, Protein Kinase Inhibitors
Additional Keywords : Drug Synergy
[+]

Effect of adlay hull extracts on testosterone release from rat Leydig cells.Apr 30, 2009

Pubmed Data : Phytother Res. 2009 May ;23(5):687-95. PMID: 19107733
Article Published Date : Apr 30, 2009
Study Type : In Vitro Study
Additional Links
Substances : Adlay
Diseases : Testosterone: Too High
Pharmacological Actions : Protein Kinase Inhibitors
Additional Keywords : Plant Extracts
[+]

Polygonum cuspidatum contains resveratrol which exhibits protein kinase C inhibitory properties.Oct 01, 1993

Pubmed Data : J Nat Prod. 1993 Oct;56(10):1805-10. PMID: 8277318
Article Published Date : Oct 01, 1993
Study Type : In Vitro Study
Additional Links
Substances : Hu Zhang (Polygonum cuspidatum), Resveratrol, Stilbenes
Pharmacological Actions : Protein Kinase C Inhibitor, Protein Kinase Inhibitors
[+]

Puerarin: A review of its mechanisms of action and clinical studies in ophthalmology.Nov 30, 2022

Pubmed Data : Phytomedicine. 2022 Dec ;107:154465. Epub 2022 Sep 19. PMID: 36166943
Article Published Date : Nov 30, 2022
Study Type : Review
Additional Links
Substances : Puerarin
Diseases : Diabetic Retinopathy, Eye Diseases, Glaucoma
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Bcl-2 protein down-regulation, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Protein Kinase Inhibitors, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Resveratrol is a protein kinase D inhibitor which may prevent and/or treat epidermal tumors.Oct 01, 2010

Pubmed Data : J Dermatol Sci. 2010 Oct;60(1):29-39. Epub 2010 Aug 10. PMID: 20832999
Article Published Date : Oct 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol
Diseases : Skin Cancer
Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Protein Kinase Inhibitors
Additional Keywords : Stilbenes

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